Sara Gredmark Russ

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Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

I vår forskargrupp arbetar vi med att förstå hur akuta virusinfektioner påverkar och påverkas av immunförsvaret, med ett speciellt intresse för fästingburen encefalit (TBE-virus) och COVID-19.

Forskningsbeskrivning

Vi forskar för att bättre förstå vad som händer i immunförsvaret vid akuta virusinfektioner, med ett särskilt intresse för fästingburen encefalit (TBE-virus) och COVID-19. Bättre kunskap om det naturliga, samt skillnader i immunsvaret vid akuta virusinfektioner, kan leda till nya insikter om akuta virussjukdomars underliggande orsaker. Det kan även leda till utveckling av nya specifika behandlingsmetoder.

Utöver en direkt ökad förståelse för de specifika virusinfektioner som vi nu studerar, kommer våra metoder att kunna användas vid studier av andra virusinfektioner och vid eventuella framtida utbrott av nya virusinfektioner.

https://ki.se/forskning/medicinvetarna-44-hur-undviks-tbe

Artiklar

Article: MICROBIOLOGY SPECTRUM. 2025;:e0018225
Serological differentiation between naturally acquired mpox and MVA-BN-vaccine induced antibody responses using ratios of MPXV and VACV antigen pairs in the MSD immunoassay
Pettke A; Keszei M; Christ W; Danes NM; Gredmark-Russ S; Soderholm S; Filen F; Storgard E; Westergren V; Yman V; Aarum J; Klingstrom J; Johansen K; Ekstrom AM; Sonden K
Article: MICROORGANISMS. 2025;13(5):1077
Dysregulated Adaptive Immune Responses to SARS-CoV-2 in Immunocompromised Individuals
Danes NM; Brownlie D; Folkman R; Nordlander A; Blom K; Varnaite R; Niessl J; Lindsjo OK; Soderholm S; Akber M; Chen P; Buggert M; Brave A; Klingstrom J; Nowak P; Marquardt N; Sonden K; Blennow O; Gredmark-Russ S
Article: JOURNAL OF INFECTIOUS DISEASES. 2025;231(1):e195-e205
Clinical Characteristics of Tick-Borne Encephalitis in Adult Patients: A 10-year Retrospective Study in Stockholm, Sweden
Bartholdsson S; Hergens M-P; Hansson KE; Ragnarsson J; Hodosi P; Kus I; Insulander M; Vene S; Lindquist L; Askling HH; Gredmark-Russ S
Article: PLOS NEGLECTED TROPICAL DISEASES. 2025;19(2):e0012693
Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohort
Wullimann D; Sandberg JT; Akber M; Lofling M; Gredmark-Russ S; Michaelsson J; Buggert M; Blom K; Ljunggren H-G
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2024;44(5):116
Severe Tick-Borne Encephalitis (TBE) in a Patient with X-Linked Agammaglobulinemia; Treatment with TBE Virus IgG Positive Plasma, Clinical Outcome and T Cell Responses
Hedin W; Bergman P; Akhirunessa M; Soderholm S; Buggert M; Granberg T; Gredmark-Russ S; Smith CIE; Pettke A; Wahren Borgstrom E
Article: JOURNAL OF IMMUNOLOGY. 2024;212(3):389-396
Dynamic MAIT Cell Recovery after Severe COVID-19 Is Transient with Signs of Heterogeneous Functional Anomalies
Kammann T; Gorin J-B; Parrot T; Gao Y; Ponzetta A; Emgard J; Maleki KT; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Skagerberg M; Eriksson LI; Norrby-Teglund A; Mak JYW; Fairlie DP; Bjorkstrom NK; Klingstrom J; Ljunggren H-G; Aleman S; Buggert M; Stralin K; Sandberg JK
Article: NATURE COMMUNICATIONS. 2023;14(1):5921
Comprehensive proteomics and meta-analysis of COVID-19 host response
Babacic H; Christ W; Araujo JE; Mermelekas G; Sharma N; Tynell J; Garcia M; Varnaite R; Asgeirsson H; Glans H; Lehtioe J; Gredmark-Russ S; Klingstroem J; Pernemalm M
Article: IMMUNITY. 2023;56(8):1955-1974.e10
Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation
Zwijnenburg AJ; Pokharel J; Varnait R; Zheng W; Hoffer E; Shryki I; Comet NR; Ehrstrom M; Gredmark-Russ S; Eidsmo L; Gerlach C
Article: LAKARTIDNINGEN. 2023;120:23101
[Neoehrlichiosis has entered the Stockholm region].
Glans H; Gunnarsson K; Gredmark Russ S
Journal article: TICK-BORNE ENCEPHALITIS - THE BOOK. 2023
Chapter 9: Immunology of TBEV infection
Gredmark-Russ S; Varnaite R
Article: RESPIRATORY RESEARCH. 2023;24(1):62
Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia
Palma Medina LM; Babacic H; Dzidic M; Parke A; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgard J; Moll K; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-JK; Sandberg J; Gredmark-Russ S; Rooyackers O; Svensson MJ; Chambers BI; Eriksson L; Pernemalm MK; Bjorkstrom N; Aleman S; Ljunggren H-G; Klingstrom J; Stralin K; Norrby-Teglund A
Article: PLOS NEGLECTED TROPICAL DISEASES. 2023;17(2):e0010616
Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial.
Sandberg JT; Löfling M; Varnaitė R; Emgård J; Al-Tawil N; Lindquist L; Gredmark-Russ S; Klingström J; Loré K; Blom K; Ljunggren H-G
Article: EMERGING INFECTIOUS DISEASES. 2022;28(10):2074-2077
Ten-Week Follow-Up of Monkeypox Case-Patient, Sweden, 2022
Pettke A; Filen F; Widgren K; Jacks A; Glans H; Andreasson S; Muradrasoli S; Helgesson S; Hauzenberger E; Karlberg ML; Walai N; Bjerkner A; Gourle H; Gredmark-Russ S; Lindsjo OK; Sonden K; Asgeirsson H
Article: EMERGING INFECTIOUS DISEASES. 2022;28(7):1471-1474
Deaths from Tick-Borne Encephalitis, Sweden
Varnaite R; Gredmark-Russ S; Klingstrom J
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195
The Karolinska KI/K COVID-19 immune atlas: An open resource for immunological research and educational purposes
Ljunggren H-G; Heggernes Ask E; Cornillet Jeannin M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio Gomez A; Dzidic M; Filipovic I; Flodstrom-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Eriksson LI; Aleman S; Malmberg K-J; Stralin K; Bjorkstrom NK
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:834862
Comparison of Lung-Homing Receptor Expression and Activation Profiles on NK Cell and T Cell Subsets in COVID-19 and Influenza
Brownlie D; Rodahl I; Varnaite R; Asgeirsson H; Glans H; Falck-Jones S; Vangeti S; Buggert M; Ljunggren H-G; Michaelsson J; Gredmark-Russ S; Smed-Sorensen A; Marquardt N
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):503-510
COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations
Cornillet M; Strunz B; Rooyackers O; Ponzetta A; Chen P; Muvva JR; Akber M; Buggert M; Chambers BJ; Dzidic M; Filipovic I; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Parrot T; Perez-Potti A; Rivera-Ballesteros O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Eriksson LI; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of in COVID-19
Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LMP; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgard J; Moll K; Garcia M; Maleki KT; Klingstrom J; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sonnerborg A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ
Article: BMC INFECTIOUS DISEASES. 2021;21(1):494
Shedding of infectious SARS-CoV-2 by hospitalized COVID-19 patients in relation to serum antibody responses
Glans H; Gredmark-Russ S; Olausson M; Falck-Jones S; Varnaite R; Christ W; Maleki KT; Karlberg ML; Broddesson S; Falck-Jones R; Bell M; Johansson N; Farnert A; Smed-Sorensen A; Klingstroem J; Brave A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingstrom J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Ginhoux F; Bjorkstrom NK; Henter J-I; Svensson M
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306
SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation
Sandberg JT; Varnaite R; Christ W; Chen P; Muvva JR; Maleki KT; Garcia M; Dzidic M; Folkesson E; Skagerberg M; Ahlen G; Frelin L; Sallberg M; Eriksson LI; Rooyackers O; Sonnerborg A; Buggert M; Bjorkstrom NK; Aleman S; Stralin K; Klingstrom J; Ljunggren H-G; Blom K; Gredmark-Russ S
Article: JOURNAL OF IMMUNOLOGY. 2020;205(9):2437-2446
Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients
Varnaite R; Garcia M; Glans H; Maleki KT; Sandberg JT; Tynell J; Christ W; Lagerqvist N; Asgeirsson H; Ljunggren H-G; Ahlen G; Frelin L; Sallberg M; Blom K; Klingstrom J; Gredmark-Russ S
Article: CELL. 2020;183(1):158-168.e14
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
Sekine T; Perez-Potti A; Rivera-Ballesteros O; Stralin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgard J; Parrot T; Folkesson E; Rooyackers O; Eriksson LI; Henter J-I; Sonnerborg A; Allander T; Albert J; Nielsen M; Klingstrom J; Gredmark-Russ S; Bjorkstrom NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670
MAIT cell activation and dynamics associated with COVID-19 disease severity
Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgard J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Bjorkstrom NK; Aleman S; Buggert M; Klingstrom J; Stralin K; Sandberg JK
Article: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2020;10:386
Genetic and Functional Characterization of Toll-Like Receptor Responses in Immunocompetent Patients With CMV Mononucleosis
Frascaroli G; Rossini G; Maltoni V; Bartoletti M; Ortolani P; Gredmark-Russ S; Gelsomino F; Moroni A; Silenzi S; Castellani G; Sambri V; Mastroianni A; Brune W; Varani S
Article: JOURNAL OF IMMUNOLOGY. 2020;204(4):914-922
Magnitude and Functional Profile of the Human CD4⁺ T Cell Response throughout Primary Immunization with Tick-Borne Encephalitis Virus Vaccine
Varnaite R; Blom K; Lampen MH; Vene S; Thunberg S; Lindquist L; Ljunggren H-G; Rombo L; Askling HH; Gredmark-Russ S
Article: CLINICAL INFECTIOUS DISEASES. 2020;70(2):245-251
Tick-borne Encephalitis Vaccine Failures: A 10-year Retrospective Study Supporting the Rationale for Adding an Extra Priming Dose in Individuals Starting at Age 50 Years
Hansson KE; Rosdahl A; Insulander M; Vene S; Lindquist L; Gredmark-Russ S; Askling HH
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2020;9(12):e1224
Innate lymphoid cell composition associates with COVID-19 disease severity
Garcia M; Kokkinou E; Carrasco Garcia A; Parrot T; Palma Medina LM; Maleki KT; Christ W; Varnaite R; Filipovic I; Ljunggren H-G; Bjorkstrom NK; Folkesson E; Rooyackers O; Eriksson LI; Sonnerborg A; Aleman S; Stralin K; Gredmark-Russ S; Klingstrom J; Mjosberg J
Article: IMMUNOHORIZONS. 2018;2(6):172-184
Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection.
Lampen MH; Uchtenhagen H; Blom K; Varnaitė R; Pakalniene J; Dailidyte L; Wälchli S; Lindquist L; Mickiene A; Michaëlsson J; Schumacher TN; Ljunggren H-G; Sandberg JK; Achour A; Gredmark-Russ S
Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2762-2771
NK Cell Responses to Human Tick-Borne Encephalitis Virus Infection
Blom K; Braun M; Pakalniene J; Lunemann S; Enqvist M; Dailidyte L; Schaffer M; Lindquist L; Mickiene A; Michaelsson J; Ljunggren H-G; Gredmark-Russ S
Article: PLOS PATHOGENS. 2015;11(1):e1004622
Specificity and Dynamics of Effector and Memory CD8 T Cell Responses in Human Tick-Borne Encephalitis Virus Infection
Blom K; Braun M; Pakalniene J; Dailidyte L; Beziat V; Lampen MH; Klingstrom J; Lagerqvist N; Kjerstadius T; Michaelsson J; Lindquist L; Ljunggren H-G; Sandberg JK; Mickiene A; Gredmark-Russ S
Article: VIRULENCE. 2012;3(7):621-634
Dendritic cell biology in human cytomegalovirus infection and the clinical consequences for host immunity and pathology
Gredmark-Russ S; Soderberg-Naucler C
Article: IMMUNOBIOLOGY. 2011;216(1-2):243-250
The novel anti-rheumatic compound Rabeximod impairs differentiation and function of human pro-inflammatory dendritic cells and macrophages
Giusti P; Frascaroli G; Tammik C; Gredmark-Russ S; Soderberg-Naucler C; Varani S
Article: JOURNAL OF VIROLOGY. 2009;83(20):10644-10652
A Gammaherpesvirus Ubiquitin-Specific Protease Is Involved in the Establishment of Murine Gammaherpesvirus 68 Infection
Gredmark-Russ S; Isaacson MK; Kattenhorn L; Cheung EJ; Watson N; Ploegh HL
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2009;87(4):347-356
Active cytomegalovirus infection in aortic smooth muscle cells from patients with abdominal aortic aneurysm
Gredmark-Russ S; Dzabic M; Rahbar A; Wanhainen A; Bjorck M; Larsson E; Michel J-B; Soderberg-Naucler C
Article: JOURNAL OF VIROLOGY. 2009;83(2):830-835
Infection with Human Cytomegalovirus Alters the MMP-9/TIMP-1 Balance in Human Macrophages
Straat K; de Klark R; Gredmark-Russ S; Eriksson P; Soderberg-Naucler C
Article: JOURNAL OF VIROLOGY. 2008;82(24):12205-12212
The CD8 T-Cell Response against Murine Gammaherpesvirus 68 Is Directed toward a Broad Repertoire of Epitopes from both Early and Late Antigens
Gredmark-Russ S; Cheung EJ; Isaacson MK; Ploegh HL; Grotenbreg GM
Article: JOURNAL OF VIROLOGY. 2007;81(19):10300-10309
A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection
Gredmark S; Schlieker C; Quesada V; Spooner E; Ploegh HL
Article: SCANDINAVIAN CARDIOVASCULAR JOURNAL. 2007;41(4):230-234
Active cytomegalovirus replication in patients with coronary disease
Gredmark S; Jonasson L; Van Gosliga D; Ernerudh J; Soderberg-Naucler C
Article: JOURNAL OF VIROLOGY. 2007;81(10):5112-5120
Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells
Gredmark S; Strååt K; Homman-Loudiyi M; Kannisto KA; Soderberg-Naucler C
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2005;25(7):e113-e116
The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents
Olofsson PS; Jatta K; Wågsäter D; Gredmark S; Hedin U; Paulsson-Berne G; Söderberg-Nauclér C; Hansson GK; Sirsjö A
Article: JOURNAL OF IMMUNOLOGY. 2004;173(8):4897-4907
Human cytomegalovirus induces inhibition of macrophage differentiation by binding to human aminopeptidase N/CD13
Gredmark S; Britt WB; Xie X; Lindbom L; Soderberg-Nauclér C
Article: JOURNAL OF VIROLOGY. 2004;78(19):10378-10389
Human cytomegalovirus inhibits cytokine-induced macrophage differentiation
Gredmark S; Tilburgs T; Söderberg-Nauclér C
Article: JOURNAL OF LIPID RESEARCH. 2004;45(9):1768-1776
Effect of macrophage differentiation and exposure to mildly oxidized LDL on the proteolytic repertoire of THP-1 monocytes
Whatling C; Björk H; Gredmark S; Hamsten A; Eriksson P
Article: JOURNAL OF VIROLOGY. 2003;77(20):10943-10956
Human cytomegalovirus inhibits differentiation of monocytes into dendritic cells with the consequence of depressed immunological functions
Gredmark S; Söderberg-Nauclér C
Visa fler

Alla övriga publikationer

Book chapter: NEUROBIOLOGY OF INFECTIOUS DISEASES. 2025;p. 451-472
Chapter 28 Tick-borne encephalitis (TBE)
Överby AK; Gredmark-Russ S
Review: FRONTIERS IN IMMUNOLOGY. 2018;9:2174
Cell-Mediated Immune Responses and Immunopathogenesis of Human Tick-Borne Encephalitis Virus-Infection
Blom K; Cuapio A; Sandberg JT; Varnaite R; Michaelsson J; Bjorkstrom NK; Sandberg JK; Klingstrom J; Lindquist L; Russ SG; Ljunggren H-G
Doctoral thesis: 2005
Biological importance of cytomegalovirus infection in health and disease : profound effects of infection on monocyte and smooth muscle cell function
Gredmark S

Forskningsbidrag

From Bedside to Bench - studies on emerging viral infections
CIMED
1 January 2021 - 31 December 2023
Från patientsäng till lab-bänk - studier av nya virusinfektioner
Högre kliniska forskare
1 January 2021 - 31 December 2024
Identification of host cell factors required for tick-borne encephalitis virus infection and replication
MIMS Clinical Research Fellowship
1 August 2020 - 30 September 2025
Tick borne encephalitis (TBE) – understanding a disease from a basic immunological standpoint for improvement of diagnostic tools, treatment and vaccination strategies
Wallenberg Clinical Fellow
1 January 2017 - 31 December 2019
Wennergren Fellow
28 August 2005 - 31 August 2010

Anställningar

Adjungerad Lektor, Medicin, Huddinge, Karolinska Institutet, 2021-2027

Examina och utbildning

Docent, Infektionssjukdomar, Karolinska Institutet, 2019
MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Solna, Karolinska Institutet, 2005
Läkarexamen, Karolinska Institutet, 2001

Om mig

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