Rodrigo Morales Castro

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: MUCOSAL IMMUNOLOGY. 2025;:S1933-0219(25)00042-X
A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing
Morales Castro RA; Kern BC; Díaz-Basabe A; Meinen ER; Zhao D; Zhou Y; Castillo F; Monasterio G; Farcas V; Chávez MN; Fransson J; Villablanca EJ
Article: NATURE. 2025;637(8048):1198-1206
Liver X receptor unlinks intestinal regeneration and tumorigenesis
Das S; Parigi SM; Luo X; Fransson J; Kern BC; Okhovat A; Diaz OE; Sorini C; Czarnewski P; Webb AT; Morales RA; Lebon S; Monasterio G; Castillo F; Tripathi KP; He N; Pelczar P; Schaltenberg N; De la Fuente M; Lopez-Kostner F; Nylen S; Larsen HL; Kuiper R; Antonson P; Hermoso MA; Huber S; Biton M; Scharaw S; Gustafsson J-A; Katajisto P; Villablanca EJ
Article: ISCIENCE. 2024;27(12):111406
Spns1-dependent endocardial lysosomal function drives valve morphogenesis through Notch1-signaling
Chavez MN; Arora P; Meer M; Marques IJ; Ernst A; Morales Castro RA; Mercader N
Article: NATURE COMMUNICATIONS. 2023;14(1):8402
Blue-shift photoconversion of near-infrared fluorescent proteins for labeling and tracking in living cells and organisms
Pennacchietti F; Alvelid J; Morales RA; Damenti M; Ollech D; Oliinyk OS; Shcherbakova DM; Villablanca EJ; Verkhusha VV; Testa I
Article: EBIOMEDICINE. 2023;94:104691
Low-grade intestinal inflammation two decades after pelvic radiotherapy
Devarakonda S; Thorsell A; Hedenstrom P; Rezapour A; Heden L; Banerjee S; Johansson MEV; Birchenough G; Moren AT; Gustavsson K; Skokic V; Pettersson VL; Sjoberg F; Kalm M; Al Masri M; Ekh M; Fagman H; Wolving M; Perkins R; Morales RA; Castillo F; Villablanca E; Yrlid U; Bergmark K; Steineck G; Bull C
Article: IMMUNITY. 2022;55(12):2336-2351.e12
B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing
Frede A; Czarnewski P; Monasterio G; Tripathi KP; Bejarano DA; Flores ROR; Sorini C; Larsson L; Luo X; Geerlings L; Novella-Rausell C; Zagami C; Kuiper R; Morales RA; Castillo F; Hunt M; Mariano LL; Hu YOO; Engblom C; Lennon-Dumenil A-M; Mittenzwei R; Westendorf AM; Hoevelmeyer N; Lundeberg J; Saez-Rodriguez J; Schlitzer A; Das S; Villablanca EJ
Article: MUCOSAL IMMUNOLOGY. 2022;15(5):940-951
Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine
Morales RA; Rabahi S; Diaz OE; Salloum Y; Kern BC; Westling M; Luo X; Parigi SM; Monasterio G; Das S; Hernandez PP; Villablanca EJ
Article: MUCOSAL IMMUNOLOGY. 2022;15(3):443-458
Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity
Melhem H; Kaya B; Kaymak T; Wuggenig P; Flint E; Roux J; Oost KC; Cavelti-Weder C; Balmer ML; Walser J-C; Morales RA; Riedel CU; Liberali P; Villablanca EJ; Niess JH
Article: NATURE COMMUNICATIONS. 2022;13(1):828
The spatial transcriptomic landscape of the healing mouse intestine following damage
Parigi SM; Larsson L; Das S; Flores ROR; Frede A; Tripathi KP; Diaz OE; Selin K; Morales RA; Luo X; Monasterio G; Engblom C; Gagliani N; Saez-Rodriguez J; Lundeberg J; Villablanca EJ
Article: DISEASE MODELS & MECHANISMS. 2021;14(12):dmm049104
Perfluorooctanesulfonic acid modulates barrier function and systemic T-cell homeostasis during intestinal inflammation
Diaz OE; Sorini C; Morales RA; Luo X; Frede A; Krais AM; Chavez MN; Wincent E; Das S; Villablanca EJ
Article: CELL REPORTS. 2020;32(5):107979
Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1⁺ Macrophages Regulates Intestinal Homeostasis
Kaya B; Donas C; Wuggenig P; Diaz OE; Morales RA; Melhem H; Hernandez PP; Kaymak T; Das S; Hruz P; Franc Y; Geier F; Ayata CK; Villablanca EJ; Niess JH
Article: REPRODUCTIVE TOXICOLOGY. 2020;93:163-168
Retinoic acid induced cytokines are selectively modulated by liver X receptor activation in zebrafish
Diaz OE; Xue S; Luo X; Nava J; Appelblom A; Morales RA; Das S; Villablanca EJ
Article: SCIENTIFIC REPORTS. 2020;10(1):2191
Autophagy Activation in Zebrafish Heart Regeneration
Chavez MN; Morales RA; Lopez-Crisosto C; Carlos Roa J; Allende ML; Lavandero S
Article: DEVELOPMENTAL NEUROSCIENCE. 2019;41(1-2):112-122
Cellular Dynamics during Spinal Cord Regeneration in Larval Zebrafish
Anguita-Salinas C; Sanchez M; Morales RA; Laura Ceci M; Rojas-Benitez D; Allende ML
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:253
Peripheral Macrophages Promote Tissue Regeneration in Zebra fish by Fine-Tuning the Inflammatory Response
Morales RA; Allende ML
Article: IMMUNOGENETICS. 2017;69(5):341-349
CXCL12a/CXCR4b acts to retain neutrophils in caudal hematopoietic tissue and to antagonize recruitment to an injury site in the zebrafish larva
Paredes-Zuniga S; Morales RA; Munoz-Sanchez S; Munoz-Montecinos C; Parada M; Tapia K; Rubilar C; Allende ML; Pena OA
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2016;117(8):1880-1889
Macrophage Recruitment Contributes to Regeneration of Mechanosensory Hair Cells in the Zebrafish Lateral Line
Carrillo SA; Anguita-Salinas C; Pena OA; Morales RA; Munoz-Sanchez S; Munoz-Montecinos C; Paredes-Zuniga S; Tapia K; Allende ML
Article: FRONTIERS IN IMMUNOLOGY. 2016;7:458
Treatment with Dexamethasone and Monophosphoryl lipid a removes Disease-associated Transcriptional signatures in Monocyte-Derived Dendritic cells from rheumatoid arthritis Patients and confers Tolerogenic Features
Garcia-Gonzalez PA; Schinnerling K; Sepulveda-Gutierrez A; Maggi J; Hoyos L; Morales RA; Mehdi AM; Nel HJ; Soto L; Pesce B; Carmen Molina M; Cuchacovich M; Larrondo ML; Neira O; Francisco Catalan D; Hilkens CM; Thomas R; Verdugo RA; Aguillon JC
Article: IMMUNOLOGY. 2015;146(1):81-88
Exogenous interleukin-33 targets myeloid-derived suppressor cells and generates periphery-induced Foxp3⁺ regulatory T cells in skin-transplanted mice
Gajardo T; Morales RA; Campos-Mora M; Campos-Acuna J; Pino-Lagos K
Article: IMMUNOBIOLOGY. 2015;220(6):769-774
Retinaldehyde dehydrogenase activity is triggered during allograft rejection and it drives Th1/Th17 cytokine production
Morales RA; Campos-Mora M; Gajardo T; Perez F; Campos J; Aguillon JC; Pino-Lagos M
Article: IMMUNOLOGY AND CELL BIOLOGY. 2015;93(2):113-119
Neuropilin-1⁺ regulatory T cells promote skin allograft survival and modulate effector CD4⁺ T cells phenotypic signature
Campos-Mora M; Morales RA; Perez F; Gajardo T; Campos J; Catalan D; Carlos Aguillon J; Pino-Lagos K
Article: PLOS ONE. 2015;10(12):e0144848
Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP plus /MPTP-Lesioned Dopaminergic Neurons
Aguirre P; Mena NP; Carrasco CM; Munoz Y; Perez-Henriquez P; Morales RA; Cassels BK; Mendez-Galvez C; Garcia-Beltran O; Gonzalez-Billault C; Nunez MT
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2013;11:128
A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines
Garcia-Gonzalez P; Morales R; Hoyos L; Maggi J; Campos J; Pesce B; Garate D; Larrondo M; Gonzalez R; Soto L; Ramos V; Tobar P; Carmen Molina M; Pino-Lagos K; Catalan D; Carlos Aguillon J
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Preprint: ELSEVIER BV. 2025
Distinct Spatiotemporal Inflammatory Programs Underlying Experimental Chronic Colitis
Fransson J; Sorini C; Castillo F; Chi Y; He N; Morales Castro RA; Sounart H; Zagami C; Cardoso RF; Das S; Giacomello S; Mechling A; Smith P; Villablanca EJ
Review: NATURE PROTOCOLS. 2024;19(10):3085-3137
A versatile tissue-rolling technique for spatial-omics analyses of the entire murine gastrointestinal tract
Monasterio G; Morales RA; Bejarano DA; Abalo XM; Fransson J; Larsson L; Schlitzer A; Lundeberg J; Das S; Villablanca EJ
Preprint: BIORXIV. 2024
Spns1-dependent endocardial lysosomal function drives valve morphogenesis through Notch1-signaling
Chávez MN; Arora P; Ernst A; Meer M; Morales RA; Mercader N
Preprint: BIORXIV. 2021
The spatial transcriptomic landscape of the healing intestine following damage
Parigi S; Larsson L; Das S; Ramirez Flores R; Frede A; Tripathi K; Diaz O; Selin K; Morales R; Luo X; Monasterio G; Engblom C; Gagliani N; Saez-Rodriguez J; Lundeberg J; Villablanca E
Preprint: BIORXIV. 2021
Epithelial GPR35 protects fromCitrobacter rodentiuminfection by preserving goblet cells and mucosal barrier integrity
Melhem H; Kaya B; Kaymak T; Wuggenig P; Flint E; Roux J; Cavelti-Weder C; Balmer M; Walser J-C; Morales R; Riedel C; Liberali P; Villablanca E; Niess JH
Preprint: BIORXIV. 2020
Lysophosphatidic acid-mediated GPR35 signaling in CX3CR1⁺macrophages regulates the intestinal cytokine milieu
Kaya B; Cuadra CD; Wuggenig P; Diaz O; Morales R; Melhem H; Swiss IBD Cohort Investigators; Hernández P; Kaymak T; Das S; Hruz P; Ayata K; Villablanca E; Niess JH
Book chapter: MOLECULAR GENETICS OF INFLAMMATORY BOWEL DISEASE. 2019;p. 47-76
Experimental Models of Intestinal Inflammation: Lessons from Mouse and Zebrafish
Diaz OE; Morales RA; Das S; Villablanca EJ
Review: FRONTIERS IN IMMUNOLOGY. 2015;6:232
Alarmin' immunologists: IL-33 as a putative target for modulating T cell-dependent responses
Gajardo Carrasco T; Morales RA; Perez F; Terraza C; Yanez L; Campos-Mora M; Pino-Lagos K
Review: FRONTIERS IN IMMUNOLOGY. 2013;4:405
Neuropilin-1 in transplantation tolerance
Campos-Mora M; Morales RA; Gajardo T; Catalan D; Pino-Lagos K

Forskningsbidrag

Utvecklingen av en zebrafisk-baserad modell för att studera tarmregeneration in vivo
KI Research Foundation
1 January 2022 - 31 December 2023
Adressera aktiviteten hos mänsklig IBD-risk genomiska icke-kodande regioner efter exponering för miljöfaktorer in vivo
KI Research Foundation
1 January 2020 - 31 December 2021

Anställningar

Biträdande Lektor, Laboratoriemedicin, Karolinska Institutet, 2024-2028
Postdoktor, Medicin, Solna, Karolinska Institutet, 2020-2024

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