Roberta Filograna

Roberta Filograna

Forskare
Besöksadress: Solnavägen 9, 9D, 17177 Stockholm
Postadress: C2 Medicinsk biokemi och biofysik, C2 Molekylär metabolism Larsson, 171 77 Stockholm

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Parkinsonfonden - Research Grant
    Parkinsonfonden - Research Grant
    1 January 2024 - 31 December 2025
  • Swedish Research Council
    1 January 2023 - 31 December 2026
    Parkinson’s disease (PD) is a common neurodegenerative disorder characterized the selective loss of dopamine (DA) neurons in the Substantia Nigra of the midbrain and severe DA depletion in the striatum, which manifest as motor impairment.More than ten million people worldwide live with PD and yet, there is currently no cure for this devastating condition. Improving our understanding of PD pathophysiology is therefore crucial to identify novel therapeutic strategies.Growing evidence indicates that mitochondrial dysfunction is heavily implicated in PD, although the underlying molecular mechanisms remain unclear. The aim of this proposal is to investigate how mitochondrial fitness is involved in the maintenance of DA neurons. In the next four year, my research team will explore in depth (i) CHCHD2 as a novel PD-gene encoding a highly conserved mitochondrial protein of unknown function
    (ii) the impact of mitochondrial dysfunction on DA neurons gene expression
    (iii) the importance of mitochondria-driven neuroinflammation in PD. At Karolinska Institutet, my research group will work in close collaboration with world-class experts in the field and employ genetic, molecular and omics approaches in order to dissect the molecular events driving DA degeneration. Our in vitro and in vivo work will provide unprecedented mechanistic insights into the role of mitochondria in PD onset and progression and set the ground for innovative and more targeted therapies.
  • Karolinska Institutet: Research Foundation Grants:
    Karolinska Institutet: Research Foundation Grants:
    1 January 2023 - 31 December 2024
  • Åhlen-stiftelsen - Research Grant
    Åhlen-stiftelsen - Research Grant
    1 January 2023 - 31 December 2024
  • StratNeuro - Starting Grant
    StratNeuro - Starting Grant
    1 January 2023 - 31 December 2025
  • Hedlunds Stiftelse - Research Grant
    Hedlunds Stiftelse - Research Grant
    1 January 2023 - 31 December 2025
  • Loo and Hans Osterman Foundation
    Loo and Hans Osterman Foundation
    1 January 2022 - 31 December 2023
  • Åhlen-stiftelsen
    Åhlen-stiftelsen
    1 January 2021 - 31 December 2022
  • Loo and Hans Osterman Foundation
    Loo and Hans Osterman Foundation
    1 January 2021 - 31 December 2022
  • Karolinska Institutet - Research Foundation Grants
    Karolinska Institutet - Research Foundation Grants
    1 January 2020 - 31 December 2022

Nyheter från KI

Kalenderhändelser från KI