Roberta Filograna
Forskare
E-postadress: roberta.filograna@ki.se
Besöksadress: Solnavägen 9, 9D, 17177 Stockholm
Postadress: C2 Medicinsk biokemi och biofysik, C2 Molekylär metabolism Larsson, 171 77 Stockholm
Artiklar
- Article: ELIFE. 2025;14:rp104461Kremer LS; Gao G; Rigoni G; Filograna R; Mennuni M; Wibom R; Vegvari A; Koolmeister C; Larsson N-G
- Article: CELLS. 2025;14(12):917Schwarz A; Qureshi AR; Hernandez L; Wennberg L; Wernerson A; Kublickiene K; Shiels PG; Filograna R; Stenvinkel P; Witasp A
- Article: SCIENCE ADVANCES. 2024;10(44):eadp3481Mennuni M; Wilkie SE; Michon P; Alsina D; Filograna R; Lindberg M; Sanin DE; Rosenberger F; Schaaf A; Larsson E; Pearce EL; Larsson N-G
- Article: NATURE METABOLISM. 2024;6(6):1024-1035Jiang S; Yuan T; Rosenberger FA; Mourier A; Dragano NRV; Kremer LS; Rubalcava-Gracia D; Hansen FM; Borg M; Mennuni M; Filograna R; Alsina D; Misic J; Koolmeister C; Papadea P; de Angelis MH; Ren L; Andersson O; Unger A; Bergbrede T; Di Lucrezia R; Wibom R; Zierath JR; Krook A; Giavalisco P; Mann M; Larsson N-G
- Article: NPJ PARKINSONS DISEASE. 2024;10(1):93Filograna R; Gerlach J; Choi H-N; Rigoni G; Barbaro M; Oscarson M; Lee S; Tiklova K; Ringner M; Koolmeister C; Wibom R; Riggare S; Nennesmo I; Perlmann T; Wredenberg A; Wedell A; Motori E; Svenningsson P; Larsson N-G
- Article: CELL METABOLISM. 2023;35(10):1799-1813.e7Milenkovic D; Misic J; Hevler JF; Molinie T; Chung I; Atanassov I; Li X; Filograna R; Mesaros A; Mourier A; Heck AJR; Hirst J; Larsson N-G
- Article: JCI INSIGHT. 2023;8(17):e167656Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Adori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; Mcinerney G; Murrell B; Aoun M; Baeckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Hedestam GBK; Dopico XC; Rorbach J
- Article: PLOS GENETICS. 2023;19(1):e1010573Kremer LS; Bozhilova LV; Rubalcava-Gracia D; Filograna R; Upadhyay M; Koolmeister C; Chinnery PF; Larsson N-G
- Journal article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:1018778Bejarano E; Antonio Rodriguez-Navarro J; Filograna R; Calvo-Garrido J
- Article: NUCLEIC ACIDS RESEARCH. 2022;50(15):8749-8766Misic J; Milenkovic D; Al-Behadili A; Xie X; Jiang M; Jiang S; Filograna R; Koolmeister C; Siira SJ; Jenninger L; Filipovska A; Clausen AR; Caporali L; Valentino ML; La Morgia C; Carelli V; Nicholls TJ; Wredenberg A; Falkenberg M; Larsson N-G
- Article: EMBO REPORTS. 2022;23(1):e53054Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screenMennuni M; Filograna R; Felser A; Bonekamp NA; Giavalisco P; Lytovchenko O; Larsson N-G
- Article: PLOS GENETICS. 2021;17(9):e1009822Filograna R; Lee S; Tiklova K; Mennuni M; Jonsson V; Ringner M; Gillberg L; Sopova E; Shupliakov O; Koolmeister C; Olson L; Perlmann T; Larsson N-G
- Article: SCIENCE ADVANCES. 2021;7(8):eabf0717Schober FA; Moore D; Atanassov I; Moedas MF; Clemente P; Vegvari A; El Fissi N; Filograna R; Bucher A-L; Hinze Y; The M; Hedman E; Chernogubova E; Begzati A; Wibom R; Jain M; Nilsson R; Kall L; Wedell A; Freyer C; Wredenberg A
- Article: NEUROTOXICITY RESEARCH. 2019;36(4):746-755Biosa A; De Lazzari F; Masato A; Filograna R; Plotegher N; Beltramini M; Bubacco L; Bisaglia M
- Article: PLOS GENETICS. 2019;15(7):e1008240Pajak A; Laine I; Clemente P; El-Fissi N; Schober FA; Maffezzini C; Calvo-Garrido J; Wibom R; Filograna R; Dhir A; Wedell A; Freyer C; Wredenberg A
- Article: SCIENCE ADVANCES. 2019;5(4):eaav9824Filograna R; Koolmeister C; Upadhyay M; Pajak A; Clemente P; Wibom R; Simard ML; Wredenberg A; Freyer C; Stewart JB; Larsson NG
- Article: HUMAN MOLECULAR GENETICS. 2018;27(9):1618-1629Biosa A; Sanchez-Martinez A; Filograna R; Terriente-Felix A; Alam SM; Beltramini M; Bubacco L; Bisaglia M; Whitworth AJ
- Article: CELL REPORTS. 2016;16(11):2980-2990Kauppila JHK; Baines HL; Bratic A; Simard M-L; Freyer C; Mourier A; Stamp C; Filograna R; Larsson N-G; Greaves LC; Stewart JB
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(17):9257-9267Filograna R; Godena VK; Sanchez-Martinez A; Ferrari E; Casella L; Beltramini M; Bubacco L; Whitworth AJ; Bisaglia M
- Journal article: JOURNAL OF NEUROINFLAMMATION. 2016;13(1):70Russo I; Berti G; Plotegher N; Bernardo G; Filograna R; Bubacco L; Greggio E
- Article: CURRENT NEUROPHARMACOLOGY. 2016;14(3):260-271Filograna R; Beltramini M; Bubacco L; Bisaglia M
- Article: JOURNAL OF NEUROINFLAMMATION. 2015;12:230Russo I; Berti G; Plotegher N; Bernardo G; Filograna R; Bubacco L; Greggio E
- Article: PLOS ONE. 2015;10(8):e0136769Filograna R; Civiero L; Ferrari V; Codolo G; Greggio E; Bubacco L; Beltramini M; Bisaglia M
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Alla övriga publikationer
- Preprint: BIORXIV. 2024Mantas I; Contestabile A; Skara V; Loiseau C; Santos IA; Cramb KML; Filograna R; Wade-Martins R; Magill P; Meletis K
- Preprint: BIORXIV. 2024Kremer L; Gao G; Rigoni G; Filograna R; Mennuni M; Wibom R; Végvári Á; Koolmeister C; Larsson N-G
- Preprint: BIORXIV. 2024Gerlach J; Pireddu P; Zhang X; Wetzel S; Mennuni M; Milenkovic D; Nolte H; Branzell N; Kaya I; Villegas RG; Rubalcava-Gracia D; Alsina D; Feederle R; Andrén P; Langer T; Svenningsson P; Filograna R
- Review: FEBS LETTERS. 2021;595(8):976-1002Filograna R; Mennuni M; Alsina D; Larsson N-G
- Review: CLINICAL GENITOURINARY CANCER. 2016;14(6):473-484Marchioni M; Primiceri G; Ingrosso M; Filograna R; Castellan P; De Francesco P; Schips L
- Review: AGEING RESEARCH REVIEWS. 2014;13:107-114Bisaglia M; Filograna R; Beltramini M; Bubacco L
Forskningsbidrag
- Parkinsonfonden - Research GrantParkinsonfonden - Research Grant1 January 2024 - 31 December 2025
- Swedish Research Council1 January 2023 - 31 December 2026Parkinson’s disease (PD) is a common neurodegenerative disorder characterized the selective loss of dopamine (DA) neurons in the Substantia Nigra of the midbrain and severe DA depletion in the striatum, which manifest as motor impairment.More than ten million people worldwide live with PD and yet, there is currently no cure for this devastating condition. Improving our understanding of PD pathophysiology is therefore crucial to identify novel therapeutic strategies.Growing evidence indicates that mitochondrial dysfunction is heavily implicated in PD, although the underlying molecular mechanisms remain unclear. The aim of this proposal is to investigate how mitochondrial fitness is involved in the maintenance of DA neurons. In the next four year, my research team will explore in depth (i) CHCHD2 as a novel PD-gene encoding a highly conserved mitochondrial protein of unknown function(ii) the impact of mitochondrial dysfunction on DA neurons gene expression(iii) the importance of mitochondria-driven neuroinflammation in PD. At Karolinska Institutet, my research group will work in close collaboration with world-class experts in the field and employ genetic, molecular and omics approaches in order to dissect the molecular events driving DA degeneration. Our in vitro and in vivo work will provide unprecedented mechanistic insights into the role of mitochondria in PD onset and progression and set the ground for innovative and more targeted therapies.
- Karolinska Institutet: Research Foundation Grants:Karolinska Institutet: Research Foundation Grants:1 January 2023 - 31 December 2024
- Åhlen-stiftelsen - Research GrantÅhlen-stiftelsen - Research Grant1 January 2023 - 31 December 2024
- StratNeuro - Starting GrantStratNeuro - Starting Grant1 January 2023 - 31 December 2025
- Hedlunds Stiftelse - Research GrantHedlunds Stiftelse - Research Grant1 January 2023 - 31 December 2025
- Loo and Hans Osterman FoundationLoo and Hans Osterman Foundation1 January 2022 - 31 December 2023
- Åhlen-stiftelsenÅhlen-stiftelsen1 January 2021 - 31 December 2022
- Loo and Hans Osterman FoundationLoo and Hans Osterman Foundation1 January 2021 - 31 December 2022
- Karolinska Institutet - Research Foundation GrantsKarolinska Institutet - Research Foundation Grants1 January 2020 - 31 December 2022