Robert Schnell

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(16):e2309211121
A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues
Szodorai E; Hevesi Z; Wagner L; Hoekfelt TGM; Harkany T; Schnell R
Article: ACS CHEMICAL BIOLOGY. 2023;18(4):794-802
Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway
Artukka E; Schnell R; Palmu K; Rosenqvist P; Szodorai E; Niemi J; Virta P; Schneider G; Metsa-Ketela M
Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2022;228:113976
Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens
Varakala SD; Reshma RS; Schnell R; Dharmarajan S
Article: CELL CHEMICAL BIOLOGY. 2021;28(9):1321-1332.e5
N-Thio-β-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis
Martelli G; Pessatti TB; Steiner EM; Cirillo M; Caso C; Bisognin F; Landreh M; Dal Monte P; Giacomini D; Schnell R
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2021;143(10):3794-3807
Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase
Schriever K; Saenz-Mendez P; Rudraraju RS; Hendrikse NM; Hudson EP; Biundo A; Schnell R; Syren P-O
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2021;30:115898
A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens
Vella P; Rudraraju RS; Lundback T; Axelsson H; Almqvist H; Vallin M; Schneider G; Schnell R
Article: JOURNAL OF MOLECULAR BIOLOGY. 2018;430(18):3170-3189
Structural and Functional Characterization of the BcsG Subunit of the Cellulose Synthase in Salmonella typhimurium
Sun L; Vella P; Schnell R; Polyakova A; Bourenkov G; Li F; Cimdins A; Schneider TR; Lindqvist Y; Galperin MY; Schneider G; Romling U
Article: PROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS. 2018;86(9):912-923
The structure of the N-terminal module of the cell wall hydrolase RipA and its role in regulating catalytic activity
Steiner EM; Lyngso J; Guy JE; Bourenkov G; Lindqvist Y; Schneider TR; Pedersen JS; Schneider G; Schnell R
Article: MOLECULAR METABOLISM. 2018;14:108-120
Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification
Malenczyk K; Szodorai E; Schnell R; Lubec G; Szabo G; Hokfelt T; Harkany T
Article: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS. 2017;27(19):4582-4587
Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis
Brunner K; Steiner EM; Reshma RS; Sriram D; Schnell R; Schneider G
Article: EMBO JOURNAL. 2017;36(14):2107-2125
A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover
Malenczyk K; Girach F; Szodorai E; Storm P; Segerstolpe A; Tortoriello G; Schnell R; Mulder J; Romanov RA; Borok E; Piscitelli F; Di Marzo V; Szabo G; Sandberg R; Kubicek S; Lubec G; Hokfelt T; Wagner L; Groop L; Harkany T
Article: THE FEBS JOURNAL. 2017;284(5):725-741
Binding and processing of β-lactam antibiotics by the transpeptidase Ldt_Mt2 from Mycobacterium tuberculosis
Steiner EM; Schneider G; Schnell R
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2016;59(14):6848-6859
Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis
Brunner K; Maric S; Reshma RS; Almqvist H; Seashore-Ludlow B; Gustavsson A-L; Poyraz O; Yogeeswari P; Lundback T; Vallin M; Sriram D; Schnell R; Schneider G
Article: ACTA CRYSTALLOGRAPHICA SECTION F:STRUCTURAL BIOLOGY COMMUNICATIONS. 2016;72(Pt 2):105-111
Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa
Jacewicz A; Schnell R; Lindqvist Y; Schneider G
Article: ACTA CRYSTALLOGRAPHICA SECTION F:STRUCTURAL BIOLOGY COMMUNICATIONS. 2015;71(Pt 8):1020-1026
Structures of Pseudomonas aeruginosa-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form
Baum B; Lecker LSM; Zoltner M; Jaenicke E; Schnell R; Hunter WN; Brenk R
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2015;71(Pt 3):721-731
Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa
Schmidberger JW; Schnell R; Schneider G
Article: EMBO JOURNAL. 2015;34(1):36-54
A secretagogin locus of the mammalian hypothalamus controls stress hormone release
Romanov RA; Alpar A; Zhang M-D; Zeisel A; Calas A; Landry M; Fuszard M; Shirran SL; Schnell R; Dobolyi A; Olah M; Spence L; Mulder J; Martens H; Palkovits M; Uhlen M; Sitte HH; Botting CH; Wagner L; Linnarsson S; Hokfelt T; Harkany T
Article: PLOS ONE. 2015;10(3):e0121494
Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium tuberculosis
Poyraz O; Brunner K; Lohkamp B; Axelsson H; Hammarstrom LGJ; Schnell R; Schneider G
Article: CEREBRAL CORTEX. 2014;24(12):3277-3288
GABAergic Terminals Are a Source of Galanin to Modulate Cholinergic Neuron Development in the Neonatal Forebrain
Keimpema E; Zheng K; Barde SS; Berghuis P; Dobszay MB; Schnell R; Mulder J; Luiten PGM; Xu ZD; Runesson J; Langel U; Lu B; Hokfelt T; Harkany T
Article: JOURNAL OF BACTERIOLOGY. 2014;196(19):3410-3420
CysK2 from Mycobacterium tuberculosis Is an O-Phospho-L-Serine-Dependent S-Sulfocysteine Synthase
Steiner EM; Both D; Lossl P; Vilaplana F; Schnell R; Schneider G
Article: BIOCHEMICAL JOURNAL. 2014;457(1):33-41
RipD (Rv1566c) from Mycobacterium tuberculosis: adaptation of an NlpC/p60 domain to a non-catalytic peptidoglycan-binding function
Both D; Steiner EM; Izumi A; Schneider G; Schnell R
Article: ACS CHEMICAL BIOLOGY. 2013;8(11):2518-2527
Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa
Cukier CD; Hope AG; Elamin AA; Moynie L; Schnell R; Schach S; Kneuper H; Singh M; Naismith JH; Lindqvist Y; Gray DW; Schneider G
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2013;56(16):6457-6466
Structure-Guided Design of Novel Thiazolidine Inhibitors of O-Acetyl Serine Sulfhydrylase from Mycobacterium tuberculosis
Poyraz O; Jeankumar VU; Saxena S; Schnell R; Haraldsson M; Yogeeswari P; Sriram D; Schneider G
Article: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS. 2013;23(5):1182-1186
Discovery of novel inhibitors targeting the Mycobacterium tuberculosis O-acetylserine sulfhydrylase (CysK1) using virtual high-throughput screening
Kumar VUJ; Poyraz O; Saxena S; Schnell R; Yogeeswari P; Schneider G; Sriram D
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2013;69(Pt 3):432-441
Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis
Both D; Steiner EM; Stadler D; Lindqvist Y; Schnell R; Schneider G
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2013;69(Pt 1):25-34
The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery
Moynie L; Schnell R; McMahon SA; Sandalova T; Boulkerou WA; Schmidberger JW; Alphey M; Cukier C; Duthie F; Kopec J; Liu H; Jacewicz A; Hunter WN; Naismith JH; Schneider G
Article: PLOS ONE. 2013;8(6):e66936
Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates
Chen MW; Lohkamp B; Schnell R; Lescar J; Schneider G
Article: PLOS ONE. 2013;8(5):e63161
Structural Insights into the UbiD Protein Family from the Crystal Structure of PA0254 from Pseudomonas aeruginosa
Jacewicz A; Izumi A; Brunner K; Schnell R; Schneider G
Article: PROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS. 2012;80(12):2799-2803
Crystal structure of NirD, the small subunit of the nitrite reductase NirbD from Mycobacterium tuberculosis at 2.0 Å resolution
Izumi A; Schnell R; Schneider G
Article: PLOS ONE. 2012;7(2):e31133
Tetrahydrodipicolinate N-Succinyltransferase and Dihydrodipicolinate Synthase from Pseudomonas aeruginosa: Structure Analysis and Gene Deletion
Schnell R; Oehlmann W; Sandalova T; Braun Y; Huck C; Maringer M; Singh M; Schneider G
Article: JOURNAL OF MOLECULAR BIOLOGY. 2011;413(1):247-260
Peptidoglycan Remodeling in Mycobacterium tuberculosis: Comparison of Structures and Catalytic Activities of RipA and RipB
Both D; Schneider G; Schnell R
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2011;67(Pt 10):1184-1188
Structure of PA4019, a putative aromatic acid decarboxylase from Pseudomonas aeruginosa
Kopec J; Schnell R; Schneider G
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):33-38
Structural enzymology of sulphur metabolism in Mycobacterium tuberculosis
Schnell R; Schneider G
Article: JOURNAL OF MOLECULAR BIOLOGY. 2009;393(4):966-977
Structural Basis for Substrate Recognition and Specificity in Aklavinone-11-Hydroxylase from Rhodomycin Biosynthesis
Lindqvist Y; Koskiniemi H; Jansson A; Sandalova T; Schnell R; Liu Z; Mantsala P; Niemi J; Schneider G
Article: FEBS LETTERS. 2009;583(2):330-336
The C-terminal of CysM from Mycobacterium tuberculosis protects the aminoacrylate intermediate and is involved in sulfur donor selectivity
Agren D; Schnell R; Schneider G
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2008;64(Pt 12):1096-1100
1.9 Å structure of the signal receiver domain of the putative response regulator NarL from Mycobacterium tuberculosis
Schnell R; Agren D; Schneider G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(46):31567-31574
Cysteine Synthase (CysM) of Mycobacterium tuberculosis Is an O-Phosphoserine Sulfhydrylase EVIDENCE FOR AN ALTERNATIVE CYSTEINE BIOSYNTHESIS PATHWAY IN MYCOBACTERIA
Agren D; Schnell R; Oehlmann W; Singh M; Schneider G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(32):23473-23481
Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis -: Crystal structures of the enzyme α-aminoacrylate intermediate and an enzyme-inhibitor complex
Schnell R; Oehlmann W; Singh M; Schneider G
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2006;62(Pt 10):1196-1207
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens
Fogg MJ; Alzari P; Bahar M; Bertini I; Betton J-M; Burmeister WP; Cambillau C; Canard B; Carrondo M; Coll M; Daenke S; Dym O; Egloff M-P; Enguita FJ; Geerlof A; Haouz A; Jones TA; Ma Q; Manicka SN; Migliardi M; Nordlund P; Owens RJ; Peleg Y; Schneider G; Schnell R; Stuart DI; Tarbouriech N; Unge T; Wilkinson AJ; Wilmanns M; Wilson KS; Zimhony O; Grimes JM
Article: BMC BIOCHEMISTRY. 2005;6:16
Analysis of Escherichia coli nicotinate mononucleotide adenylyltransferase mutants in vivo and in vitro.
Stancek M; Schnell R; Rydén-Aulin M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):27319-27328
Siroheme- and [Fe₄-S₄]-dependent NirA from Mycobacterium tuberculosis is a sulfite reductase with a covalent Cys-Tyr bond in the active site
Schnell R; Sandalova T; Hellman U; Lindqvist Y; Schneider G
Article: FEBS LETTERS. 2003;538(1-3):139-144
Functional EF-Tu with large C-terminal extensions in an E-coli strain with a precise deletion of both chromosomal tuf genes
Schnell R; Abdulkarim F; Kálmán M; Isaksson LA
Article: JOURNAL OF BACTERIOLOGY. 2002;184(17):4930-4932
The metD D-methionine transporter locus of Escherichia coli is an ABC transporter gene cluster
Gál J; Szvetnik A; Schnell R; Kálmán M
Article: BIOLOGIA FUTURA. 2002;53(4):445-464
Visual event related potentials.: The origin of wave p300.: A computer model
Fehér O; Schnell R
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2001;1544(1-2):378-385
Ribosomes with large synthetic N-terminal extensions of protein S15 are active in vivo
Walles-Granberg A; Schnell R; Isaksson LA; Rydén-Aulin M
Article: ANALYTICAL BIOCHEMISTRY. 2000;282(1):156-158
Polymerase dependence of autosticky polymerase chain reaction
Gál J; Schnell R; Kálmán M
Article: ANALYTICAL BIOCHEMISTRY. 1999;266(2):235-238
A positive selection cloning system based on the gltS gene of Escherichia coli
Gál J; Szekeres S; Schnell R; Pongor S; Simoncsits A; Kálmán M
Article: MOLECULAR GENETICS AND GENOMICS. 1999;260(6):569-573
Directional cloning of native PCR products with preformed sticky ends (Autosticky PCR)
Gál J; Schnell R; Szekeres S; Kálmán M
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Alla övriga publikationer

Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1854(9):1175-1183
Pyridoxal-phosphate dependent mycobacterial cysteine synthases: Structure, mechanism and potential as drug targets
Schnell R; Sriram D; Schneider G
Corrigendum: PLOS ONE. 2015;10(4):e0127016
Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium tuberculosis (vol 10, e0121494, 2015)
Poyraz O; Brunner K; Lohkamp B; Axelsson H; Hammarstroem LGJ; Schnell R
Corrigendum: ACTA CRYSTALLOGRAPHICA SECTION D: STRUCTURAL BIOLOGY. 2006;62:1571
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens (vol 62, pg 1196, 2006)
Fogg MJ; Alzari P; Bahar M; Bertini I; Betton J-M; Burmeister WP; Cambillau C; Canard B; Carrondo MA; Coll M; Daenke S; Dym O; Egloff M-P; Enguita FJ; Geerlof A; Haouz A; Jones TA; Qingjun M; Manicka SN; Migliardi M; Nordlund P; Owens RJ; Peleg Y; Schneider G; Schnell R; Stuart DI; Tarbouriech N; Unge T; Wilkinson AJ; Wilmanns M; Wilson KS; Zimhony O; Grimes JM

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