Richard Cowburn

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Artiklar

Article: THE FEBS JOURNAL. 2015;282(1):65-73
Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production
Stromberg K; Eketjall S; Georgievska B; Tunblad K; Eliason K; Olsson F; Radesater A-C; Klintenberg R; Arvidsson PI; von Berg S; Falting J; Cowburn RF; Dabrowski M
Article: BRAIN PATHOLOGY. 2013;23(4):378-389
Tau-Tubulin Kinase 1 Expression, Phosphorylation and Co-Localization with Phospho-Ser422 Tau in the Alzheimer's Disease Brain
Lund H; Cowburn RF; Gustafsson E; Stromberg K; Svensson A; Dahllund L; Malinowsky D; Sunnemark D
Article: AUTOPHAGY. 2011;7(12):1528-1545
Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells
Zheng L; Terman A; Hallbeck M; Dehvari N; Cowburn RF; Benedikz E; Kagedal K; Cedazo-Minguez A; Marcusson J
Journal article: JOURNAL OF PHARMACY AND PHARMACOLOGY. 2011;40(4):307-308
Dopamine and apomorphine do not modulate the uptake of [3H]D-aspartate in the rat striatum in-vitro.
O'Connor I; Cowburn RF; Hardy JA; Fowler CJ
Journal article: ALZHEIMER'S AND DEMENTIA. 2010;6(4S_Part_20):e32
P4‐042: The Role of Oxidative Stress and Autophagy in Amyloid Beta‐protein Toxicity to Cultured Neuroblastoma Cells
Zheng L; Dehvari N; Benedikz E; Cowburn R; Terman A; Cedazo-Minguez A; Marcusson J
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2009;13(9B):3061-3068
Parkin-mediated ubiquitination regulates phospholipase C-γ1
Dehvari N; Sandebring A; Flores-Morales A; Mateos L; Chuan Y-C; Goldberg MS; Cookson MR; Cowburn RF; Cedazo-Minguez A
Article: THE FEBS JOURNAL. 2009;276(18):5041-5052
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling
Sandebring A; Dehvari N; Perez-Manso M; Thomas KJ; Karpilovski E; Cookson MR; Cowburn RF; Cedazo-Minguez A
Journal article: ALZHEIMER'S AND DEMENTIA. 2009;5(4S_Part_7):p224-p225
P1‐161: The role of APP processing in oxidant‐induced damage in cultured neuroblastoma cells
Zheng L; Dehvari N; Kågedal K; Benedikz E; Cowburn R; Terman A; Marcusson J
Article: PLOS ONE. 2009;4(5):e5701
Mitochondrial Alterations in PINK1 Deficient Cells Are Influenced by Calcineurin-Dependent Dephosphorylation of Dynamin-Related Protein 1
Sandebring A; Thomas KJ; Beilina A; van der Brug M; Cleland MM; Ahmad R; Miller DW; Zambrano I; Cowburn RF; Behbahani H; Cedazo-Minguez A; Cookson MR
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;46(3):422-429
Oxidative stress induces macroautophagy of amyloid β-protein and ensuing apoptosis
Zheng L; Kagedal K; Dehvari N; Benedikz E; Cowburn R; Jan M; Terman A
Journal article: ALZHEIMER'S AND DEMENTIA. 2008;4(4S_Part_20):t639-t640
P3‐403: Parkin ubiquitylates phospholipase C–γ1 and protects against dopamine induced cell death
Dehvari N; Sandebring A; Flores-Morales A; Mateos L; Karpilovski E; Cookson MR; Goldberg MS; Cowburn RF; Cedazo-Minguez A
Article: NEUROSCIENCE LETTERS. 2008;436(1):77-80
Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism
Dehvari N; Isacsson O; Winblad B; Cedazo-Minguez A; Cowburn RF
Article: PHYSIOLOGY AND BEHAVIOR. 2007;92(1-2):93-97
Presenilin-mediated signal transduction
Cowburn RF; Popescu BO; Ankarcrona M; Dehvari N; Cedazo-Minguez A
Article: JOURNAL OF NEUROCHEMISTRY. 2007;102(3):848-857
Presenilin dependence of phospholipase C and protein kinase C signaling
Dehvari N; Cedazo-Minguez A; Isacsson O; Nilsson T; Winblad B; Karlstrom H; Benedikz E; Cowburn RF
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2006;84(4):891-902
Differential role of presenilin-1 and-2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts
Behbahani H; Shabalina IG; Wiehager B; Concha H; Hultenby K; Petrovic N; Nedergaard J; Winblad B; Cowburn RF; Ankarcrona M
Article: CELL DEATH AND DIFFERENTIATION. 2006;13(9):1454-1465
Involvement of glutaredoxin-1 and thioredoxin-1 in β-amyloid toxicity and Alzheimer's disease
Akterin S; Cowburn RF; Miranda-Vizuete A; Jimenez A; Bogdanovic N; Winblad B; Cedazo-Minguez A
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2006;84(3):596-605
PTEN, Akt, and GSK3β signalling in rat primary cortical neuronal cultures following tumor necrosis factor-α and trans-4-hydroxy-2-nonenal treatments
Rickle A; Behbahani H; Ankarcrona M; Winblad B; Cowburn RF
Journal article: ALZHEIMER'S AND DEMENTIA. 2006;2(3S_Part_16):s495-s496
P3–407: Presenilin dependence of phospholipase C and associated signalling
Dehvari N; Cedazo-Minguez A; Isacsson O; Nilsson T; Winblad B; Benedikz E; Cowburn RF
Journal article: ALZHEIMER'S AND DEMENTIA. 2006;2(3S_Part_16):s485
P3–374: PINK1 transfected cell lines exhibit mitochondrial protection in vitro when exposed to mitochondrial toxins
Sandebring A; Beilina A; Behbahani H; Cowburn RF; Cookson MR
Journal article: ALZHEIMER'S AND DEMENTIA. 2006;2(3S_Part_16):s488
P3–383: Involvement of glutaredoxin–1 and thioredoxin–1 in beta–amyloid toxicity and Alzheimer's disease
Akterin S; Sandebring A; Cowburn RF; Miranda-Vizuete A; Jimanez A; Bogdanovic N; Winblad B; Cedazo-Manguez A
Article: NEUROREPORT. 2006;17(9):907-911
Increased tau phosphorylation at the Ser³⁹⁶ epitope after amyloid beta-exposure in organotypic cultures
Johansson S; Jamsa A; Vasange M; Winblad B; Luthman J; Cowburn RF
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;345(1):324-331
Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells
Jämsä A; Bäckström A; Gustafsson E; Dehvari N; Hiller G; Cowburn RF; Vasänge M
Article: OSTEOARTHRITIS AND CARTILAGE. 2006;14(6):519-525
Assorted effects of TGFβ and chondroitinsulfate on p38 and ERK1/2 activation levels in human articular chondrocytes stimulated with LPS
Holzmann J; Brandl N; Zemann A; Schabus R; Marlovits S; Cowburn R; Huettinger M
Article: FEBS LETTERS. 2006;580(13):3121-3128
PTEN, a negative regulator of P13 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3
Kerr F; Rickle A; Nayeem N; Brandner S; Cowburn RF; Lovestone S
Article: BRAIN RESEARCH BULLETIN. 2006;69(1):79-85
Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation.
Murphy EJ; Huang H-M; Cowburn RF; Lannfelt L; Gibson GE
Article: NEUROCHEMISTRY INTERNATIONAL. 2006;48(2):114-123
PTEN levels in Alzheimer's disease medial temporal cortex
Rickle A; Bogdanovic N; Volkmann I; Zhou XW; Pei JJ; Winblad B; Cowburn RF
Article: EXPERIMENTAL BRAIN RESEARCH. 2006;168(1-2):11-24
Modelling of amyloid β-peptide induced lesions using roller-drum incubation of hippocampal slice cultures from neonatal rats
Johansson S; Radesater AC; Cowburn RF; Thyberg J; Luthman J
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2005;82(3):432-441
Flow cytometry as a method for studying effects of stressors on primary rat neurons
Behbahani H; Rickle A; Concha H; Ankarcrona M; Winblad B; Cowburn RF
Article: BRAIN RESEARCH. 2005;135(1-2):40-47
Zinc-induced anti-apoptotic effects in SH-SY5Y neuroblastoma cells via the extracellular signal-regulated kinase 1/2
An WL; Pei JJ; Nishimura T; Winblad B; Cowburn RF
Article: JOURNAL OF NEUROCHEMISTRY. 2005;92(5):1104-1115
Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3β in SH-SY5Y neuroblastoma cells
An WL; Bjorkdahl C; Liu R; Cowburn RF; Winblad B; Pei JJ
Article: BIOCHEMICAL JOURNAL. 2005;385(Pt 2):545-550
Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; Johnston JA
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(49):51654-51660
Nicastrin, presenilin, APH-1, and PEN-2 form active γ-secretase complexes in mitochondria
Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
Article: DEVELOPMENTAL BRAIN RESEARCH. 2004;151(1-2):75-86
Distribution of presenilin 1 and 2 and their relation to Notch receptors and ligands in human embryonic/foetal central nervous system
Kostyszyn B; Cowburn RF; Seiger Å; Kjældgaard B; Sundström E
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;319(3):993-1000
The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation
Jämsä A; Hasslund K; Cowburn RF; Bäckström A; Vasänge M
Article: NEUROCHEMISTRY INTERNATIONAL. 2004;44(7):487-496
Presenilin expression during induced differentiation of the human neuroblastoma SH-SY5Y cell line
Flood F; Sundström E; Samuelsson EB; Wiehager B; Seiger Å; Johnston JA; Cowburn RF
Article: NEUROREPORT. 2004;15(6):955-959
Akt activity in Alzheimer's disease and other neurodegenerative disorders.
Rickle A; Bogdanovic N; Volkman I; Winblad B; Ravid R; Cowburn RF
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(8):6455-6464
γ-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction
Popescu BO; Cedazo-Minguez A; Benedikz E; Nishimura T; Winblad B; Ankarcrona M; Cowburn RF
Article: JOURNAL OF NEUROCHEMISTRY. 2003;87(5):1152-1164
Apolipoprotein E and β-amyloid (1-42) regulation of glycogen synthase kinase-3β
Cedazo-Mínguez A; Popescu BO; Blanco-Millán JM; Akterin S; Pei JJ; Winblad B; Cowburn RF
Article: AMERICAN JOURNAL OF PATHOLOGY. 2003;163(3):845-858
Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK-1/2, and p70 S6, similar to that in Alzheimer's disease
Pei JJ; Gong CX; An WL; Winblad B; Cowburn RF; Grundke-Iqbal I; Iqbal K
Article: NEUROREPORT. 2003;14(11):1523-1527
G-protein α-subunit levels in hippocampus and entorhinal cortex of brains staged for Alzheimer's disease neurofibrillary and amyloid pathologies
García-Jiménez A; Fastbom J; Ohm TG; Cowburn RF
Article: AMERICAN JOURNAL OF PATHOLOGY. 2003;163(2):591-607
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
An WL; Cowburn RF; Li L; Braak H; Alafuzoff I; Iqbal K; Iqbal IG; Winblad B; Pei JJ
Article: ACTA NEUROPATHOLOGICA. 2003;105(4):381-392
Role of protein kinase B in Alzheimer's neurofibrillary pathology
Pei JJ; Khatoon S; An WL; Nordlinder M; Tanaka T; Braak H; Tsujio I; Takeda M; Alafuzoff I; Winblad B; Cowburn RF; Grundke-Iqbal I; Iqbal K
Article: BRAIN RESEARCH. 2002;109(1-2):45-55
Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease
Pei JJ; Braak H; An WL; Winblad B; Cowburn RF; Iqbal K; Grundke-Iqbal I
Article: ACTA NEUROPATHOLOGICA. 2002;104(4):369-376
Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration
Pei JJ; Braak H; Gong CX; Grundke-Iqbal I; Iqbal K; Winblad B; Cowburn RF
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(39):36646-36655
The presenilin 1 ΔE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations
Cedazo-Mínguez A; Popescu BO; Ankarcrona M; Nishimura T; Cowburn RF
Article: BRAIN RESEARCH. 2002;949(1-2):105-111
Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation.
Smith IF; Boyle JP; Vaughan PFT; Pearson HA; Cowburn RF; Peers CS
Article: NEUROREPORT. 2002;13(12):1553-1556
Presenilin-I mutations alter K⁺ currents in the human neuroblastoma cell line, SH-SY5Y
Plant LD; Boyle JP; Thomas NM; Hipkins NJ; Benedikz E; Hooper NM; Henderson Z; Vaughan PFT; Peers C; Cowburn RF; Pearson HA
Article: CURRENT OPINION IN PSYCHIATRY. 2002;15(4):395-401
Alzheimer's disease: mutations, apoptosis and cellular signalling
Vestling M; Cowburn RF; Winblad B; Ankarcrona M
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2002;67(3):388-398
Loss of stimulatory effect of guanosine triphosphate on [³⁵S]GTPγS binding correlates with Alzheimer's disease neurofibrillary pathology in entorhinal cortex and CA1 hippocampal subfield
García-Jiménez A; Cowburn RF; Ohm TG; Lasn H; Winblad B; Bogdanovic N; Fastbom A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(51):48554-48561
Presenilin 1 independently regulates β-catenin stability and transcriptional activity
Killick R; Pollard CC; Asuni AA; Mudher AK; Richardson JC; Rupniak HT; Sheppard PW; Varndell IM; Brion JP; Levey AI; Levy OA; Vestling M; Cowburn R; Lovestone S; Anderton BH
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2001;66(3):448-456
Akt activity in presenilin 1 wild-type and mutation transfected human SH-SY5Y neuroblastoma cells after serum deprivation and high glucose stress
Vestling M; Wiehager B; Tanii H; Cowburn RF
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2001;66(1):122-134
Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells
Popescu BO; Cedazo-Minguez A; Popescu LM; Winblad B; Cowburn RF; Ankarcrona M
Article: FEBS LETTERS. 2001;504(1-2):45-49
Apolipoprotein E isoform-specific disruption of phosphoinositide hydrolysis:: protection by estrogen and glutathione
Cedazo-Mínguez A; Cowburn RF
Journal article: HUMAN GENETICS. 2001;108(6):556
Nigel M. Hooper (editor): Alzheimer’s disease. Methods and protocols
Cowburn RF
Article: NEUROCHEMISTRY INTERNATIONAL. 2001;38(7):615-625
Effects of apolipoprotein E (apoE) isoforms, β-amyloid (Aβ) and apoE/Aβ complexes on protein kinase C-α (PKC-α) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
Cedazo-Mínguez A; Wiehager B; Winblad B; Hüttinger M; Cowburn RF
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2001;3(1):41-48
Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration
Pei J-J; Braak E; Braak H; Grundke-Iqbal I; Iqbal K; Winblad B; Cowburn RF
Article: NEUROREPORT. 2001;12(2):201-206
β-VLDL protects against Aβ(I-42) and apoE toxicity in human SH-SY5Y neuroblastoma cells
Cedazo-Mínguez A; Hüttinger M; Cowburn RF
Article: NEUROSCIENCE. 2001;105(3):651-661
Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures
Cedazo-Mínguez A; Hamker U; Meske V; Veh RW; Hellweg R; Jacobi C; Albert F; Cowburn RF; Ohm TG
Article: NEUROSCIENCE. 2001;103(4):885-898
Expression of presenilin-1 and notch-1 receptor in human embryonic CNS
Kostyszyn B; Cowburn RF; Seiger Å; Kjaeldgaard A; Sundström E
Journal article: NEUROBIOLOGY OF AGING. 2000;21:252
Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures
Cedazo-Minguez A; Hamker U; Veh R; Meske V; Albert F; Cowburn RF; Ohm TG
Journal article: NEUROBIOLOGY OF AGING. 2000;21:120
Loss of G-protein activity in entorhinal cortex and hippocampus in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and β-amyloid deposits
Garcia-Jimenez A; Cowburn RF; Ohm TG; Bogdanovic N; Winblad B; Fastbom J
Journal article: NEUROBIOLOGY OF AGING. 2000;21:163
Effects of presenilin-1 exon 9 deletion and L250S mutations on hyperosmotic stress-induced apoptosis and caspase activities in SH-SY5Y neuroblastoma cells
Cowburn RF; Sekiyama A; Tanii H; Nilsberth C; Winblad B; Benedikz E; Ankarcrona M
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2000;28(1):a17
Receptor – G-protein signalling in Alzheimer's disease
Cowburn RF; O'Neill C; Bonkale WL; Ohm TG; Fastbom J
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2000;28(1):a18
Dysfunctional ryanodine receptor calcium release channels in Alzheimer's disease
O'Neill C; Fastbom J; Cowburn R; Carmody M; Ohm TG; Kelliher M
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2000;28(1):a38
Reduced [3H]cGMP binding in brain staged for Alzheimer's disease pathologies
Bonkale WL; Cowburn RF; Bogdanovic N; Ohm TG; Fastborn J
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2000;28(1):a16
ApoE and β-amyloid: signals and effects
Ohm TG; Hamker U; Cedazzo A; Müller W; Cowburn R; Röckl W; März W; Scharnagl H; Meske V
Article: NEUROSCIENCE. 2000;95(2):593-601
Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis
Tanii H; Ankarcrona M; Flood F; Nilsberth C; Mehta ND; Perez-Tur J; Winblad B; Benedikz E; Cowburn RF
Article: BRAIN RESEARCH. 1999;850(1-2):104-117
Quantitative autoradiography of [³H]forskolin binding sites in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits
García-Jiménez A; Cowburn RF; Ohm TG; Bogdanovic N; Winblad B; Fastbom J
Article: NEUROCHEMISTRY INTERNATIONAL. 1999;35(4):307-315
Nicergoline stimulates protein kinase C mediated α-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells
Cedazo-Minguez A; Bonecchi L; Winblad B; Post C; Wong EHF; Cowburn RF; Benatti L
Article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 1999;58(9):1010-1019
Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes
Pei JJ; Braak E; Braak H; Grundke-Iqbal I; Iqbal K; Winblad B; Cowburn RF
Article: NEUROREPORT. 1999;10(11):2423-2427
Inhibition of [³H]forskolin binding by Gpp[NH]p may reflect adenylate cyclase coupling to G_i
Garcia-Jiménez A; Cowburn RF; Winblad B; Fastbom J
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1999;1453(3):341-350
Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases
Vestling M; Cedazo-Mínguez A; Adem A; Wiehager B; Racchi M; Lannfelt L; Cowburn RF
Article: BIOCHEMICAL JOURNAL. 1999;338 ( Pt 3)(Pt 3):777-782
Amyloid precursor protein metabolism in fibroblasts from individuals with one, two or three copies of the amyloid precursor protein (APP) gene.
Racchi M; Johnston JA; Flood FM; Cowburn RF; Govoni S
Article: BRAIN RESEARCH. 1999;818(2):383-396
A quantitative autoradiographic study of [³H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits
Bonkale WL; Cowburn RF; Ohm TG; Bogdanovic N; Fastbom J
Article: NEUROSCIENCE. 1999;92(2):499-513
Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and β-amyloid pathologies
Kelliher M; Fastbom J; Cowburn RF; Bonkale W; Ohm TG; Ravid R; Sorrentino V; O'Neill C
Article: NEUROREPORT. 1998;9(14):3329-3333
Inhibition of [³H]forskolin binding by Gpp[NH]p may reflect adenylyl cyclase coupling to G_i
García-Jiménez A; Cowburn RF; Einblad B; Fastbom J
Article: ANNALS OF NEUROLOGY. 1998;44(4):676-681
α-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation
Gibson GE; Zhang H; Sheu KFR; Bogdanovich N; Lindsay JG; Lannfelt L; Vestling M; Cowburn RF
Article: BRAIN RESEARCH. 1998;797(2):267-277
Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration
Pei JJ; Grundke-Iqbal I; Iqbal K; Bogdanovic N; Winblad B; Cowburn RF
Article: BRAIN RESEARCH. 1998;796(1-2):209-221
Loss of inositol 1,4,5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neurofibrillary pathology
Kurumatani T; Fastbom J; Bonkale WL; Bogdanovic N; Winblad B; Ohm TG; Cowburn RF
Article: JOURNAL OF NEURAL TRANSMISSION. 1998;105(1):69-84
Subcellular distribution of protein phosphatases and abnormally phosphorylated τ in the temporal cortex from Alzheimer's disease and control brains
Pei JJ; Gong CX; Iqbal K; Grundke-Iqbal I; Wu QL; Winblad B; Cowburn RF
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1997;1362(2-3):183-192
Amyloid precursor protein heat shock response in lymphoblastoid cell lines bearing presenilin-1 mutations
Johnston JA; Lannfelt L; Wiehager B; O'Neill C; Cowburn RF
Article: NEUROCHEMICAL RESEARCH. 1997;22(12):1437-1442
Effects of beta-amyloid-(25-35) peptides on radioligand binding to excitatory amino acid receptors and voltage-dependent calcium channels: Evidence for a selective affinity for the glutamate and glycine recognition sites of the NMDA receptor
Cowburn RF; Wiehager B; Trief E; LiLi M; Sundstrom E
Article: NEUROBIOLOGY OF AGING. 1997;18(6):573-580
Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation
Gibson GE; Vestling M; Zhang H; Szolosi S; Alkon D; Lannfelt L; Gandy S; Cowburn RF
Article: NEUROSCIENCE LETTERS. 1997;235(1-2):17-20
Presenilin-1, amyloid precursor protein and amyloid precursor-like protein 2 mRNA levels in human superior frontal cortex during aging.
Flood FM; Cowburn RF; Johnston JA
Article: NEUROSCIENCE LETTERS. 1997;234(1):3-6
A novel pathogenic mutation (Leu262Phe) found in the presenilin 1 gene in early-onset Alzheimer's disease
Forsell C; Froelich S; Axelman K; Vestling M; Cowburn RF; Lilius L; Johnston JA; Engvall B; Johansson K; Dahlkild A; Ingelson M; StGeorgeHyslop PH; Lannfelt L
Article: NEUROSCIENCE LETTERS. 1997;232(1):33-36
G protein subunit levels in fibroblasts from familial Alzheimer's disease patients: lower levels of the high molecular weight Gs alpha isoform in patients with decreased beta-adrenergic receptor stimulated cAMP formation
Shanahan C; Gibson GE; Cowburn RF; Johnston JA; Wiehager B; Lannfelt L; ONeill C
Article: NEUROCHEMICAL RESEARCH. 1997;22(8):1055-1063
Autoradiographic characterisation of [S-35]GTP gamma S binding sites in rat brain
GarciaJimenez A; Cowburn RF; Winblad B; Fastbom J
Article: BRAIN RESEARCH. 1997;763(1):1-13
Autoradiographic characterization of [H-3]cGMP binding sites in the rat brain
Bonkale WL; Cowburn RF; Winblad B; Fastbom J
Article: NEUROSCIENCE LETTERS. 1997;229(2):85-88
Cerebrospinal fluid apolipoprotein E (apoE) levels in Alzheimer's disease patients are increased at follow up and show a correlation with levels of tau protein
Lindh M; Blomberg M; Jensen M; Basun H; Lannfelt L; Engvall B; Scharnagel H; Marz W; Wahlund LO; Cowburn RF
Article: NEUROREPORT. 1997;8(8):2031-2035
Differential regulation of adenylyl cyclase in fibroblasts from sporadic and familial Alzheimer's disease cases with PS1 and APP mutations
Vestling M; Adem A; Racchi M; Gibson GE; Lannfelt L; Cowburn RF
Article: NEUROSCIENCE LETTERS. 1997;226(1):37-40
Decreased beta-adrenoceptor-stimulated adenylyl cyclase activity in lymphocytes from Alzheimer's disease patients
Garlind A; Johnston JA; Algotsson A; Winblad B; Cowburn RF
Article: GERONTOLOGY. 1997;43(1-2):132-142
Alzheimer's, ageing and amyloid: an absurd allegory?
Fowler CJ; Cowburn RF; Joseph JA
Article: JOURNAL OF NEURAL TRANSMISSION. 1997;104(2-3):175-189
Autoradiographic characterization of [H-3]inositol(1,4,5)trisphosphate and [H-3]inositol(1,3,4,5)tetrakisphosphate binding sites in human brain
Kurumatani T; Cowburn RF; Bogdanovic N; Winblad B; Fastbom J
Article: JOURNAL OF NEURAL TRANSMISSION. 1997;104(11-12):1329-1338
Elevated protein levels of protein phosphatases PP-2A and PP-2B in astrocytes of Alzheimer's disease temporal cortex
Pei JJ; Grundke-Iqbal I; Iqbal K; Bogdanovic N; Winblad B; Cowburn RF
Article: BRAIN RESEARCH. 1996;43(1-2):85-95
Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brains
Johnston JA; Norgren S; Ravid R; Wasco W; Winblad B; Lannfelt L; Cowburn RF
Article: BRAIN RESEARCH. 1996;43(1-2):77-84
A new quantitative solution hybridisation-RNase protection assay for APP and APLP2 mRNA
Johnston JA; Norgren S; Anneren G; Cowburn RF; Lannfelt L
Article: EXPERIMENTAL NEUROLOGY. 1996;5(4):483-488
Neurotransmitter receptor/G-protein mediated signal transduction in Alzheimer's disease brain.
Cowburn RF; Fowler CJ; O'Neill C
Article: BRAIN RESEARCH. 1996;737(1-2):155-161
Impaired G-protein-stimulated adenylyl cyclase activity in Alzheimer's disease brain is not accompanied by reduced cyclic-AMP-dependent protein kinase A activity
Bonkale WL; Fastbom J; Wiehager B; Ravid R; Winblad B; Cowburn RF
Article: FEBS LETTERS. 1996;394(3):279-284
Quantification of presenilin-1 mRNA in Alzheimer's disease brains.
Johnston JA; Froelich S; Lannfelt L; Cowburn RF
Article: EXPERIMENTAL NEUROLOGY. 1996;5(2):169-176
Decreased inositol (1,4,5)-trisphosphate receptor levels in Alzheimer's disease cerebral cortex: Selectivity of changes and possible correlation to pathological severity
Haug LS; Ostvold AC; Cowburn RF; Garlind A; Winblad B; Bogdanovich N; Walaas SI
Article: EXPERIMENTAL NEUROLOGY. 1996;5(1):19-26
Acetylcholine muscarinic M2 receptor stimulated [S-35]GTP gamma S binding shows regional selective changes in Alzheimer's disease postmortem brain
Cowburn RF; Wiehager B; Ravid R; Winblad B
Journal article: NEUROBIOLOGY OF AGING. 1996;17(4):s57
227 Quantitative solution hybridisation assay of APP and APLP2 mRNA in Alzheimer's disease cerebral cortex
Johnston JA; Norgren S; Ravid R; Lannfelt L; Cowburn RF
Journal article: NEUROBIOLOGY OF AGING. 1996;17(4):s57
226 Effect of fibroblast growth factor and insulin on β-amyloid production in normal and familial Alzheimer's disease fibroblasts
Vigo-Pelfrey C; Cedazo-Minguez A; Cowburn RF; Jensen M; Lannfelt L; Johnston JA
Journal article: NEUROBIOLOGY OF AGING. 1996;17(4):s59
235 Apolipoprotein E levels in plasma and CSF from members of the Swedish Alzheimer's disease APP 670/671 mutation family and sporadic Alzheimer's disease cases
Lindh M; Blomberg M; Jensen M; Wahlund L-O; März W; Scharnagl H; Lannfelt L; Cowburn RF
Article: NEUROREPORT. 1995;7(1):297-301
A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene.
Perez-Tur J; Froelich S; Prihar G; Crook R; Baker M; Duff K; Wragg M; Busfield F; Lendon C; Clark RF
Article: MOLECULAR AND CELLULAR BIOCHEMISTRY. 1995;149:287-292
DISTURBANCES IN SIGNAL-TRANSDUCTION MECHANISMS IN ALZHEIMERS-DISEASE
FOWLER CJ; COWBURN RF; GARLIND A; WINBLAD B; ONEILL C
Article: BRAIN RESEARCH. 1995;681(1-2):160-166
DIMINISHED [H-3] INOSITOL(1,4,5)P-3, BUT NOT [H-3] INOSITOL(1,3,4,5)P-4 BINDING IN ALZHEIMERS-DISEASE BRAIN
GARLIND A; COWBURN RF; FORSELL C; RAVID R; WINBLAD B; FOWLER CJ
Article: NEUROSCIENCE LETTERS. 1995;191(1-2):31-34
BETA-AMYLOID PEPTIDES ENHANCE BINDING OF THE CALCIUM MOBILIZING 2ND MESSENGERS, INOSITOL(1,4,5)TRISPHOSPHATE AND INOSITOL(1,3,4,5)TETRAKISPHOSPHATE TO THEIR RECEPTOR-SITES IN RAT CORTICAL MEMBRANES
COWBURN RF; WIEHAGER B; SUNDSTROM E
Article: NEUROSCIENCE LETTERS. 1995;187(1):5-8
REDUCED NITRIC-OXIDE RESPONSIVE SOLUBLE GUANYLYL CYCLASE ACTIVITY IN THE SUPERIOR TEMPORAL CORTEX OF PATIENTS WITH ALZHEIMERS-DISEASE
BONKALE WL; WINBLAD B; RAVID R; COWBURN RF
Article: NEUROSCIENCE LETTERS. 1995;186(1):57-60
PRESERVATION OF ACETYLCHOLINE MUSCARINIC M2 RECEPTOR G-PROTEIN INTERACTIONS IN THE NEOCORTEX OF PATIENTS WITH ALZHEIMERS-DISEASE
HERNANDEZHERNANDEZ A; ADEM A; RAVID R; COWBURN RF
Article: NEUROSCIENCE LETTERS. 1995;185(2):131-134
PRESERVATION OF KAPPA(1) OPIOID RECEPTOR RECOGNITION SITE DENSITY AND REGULATION BY G-PROTEINS IN THE TEMPORAL CORTEX OF PATIENTS WITH ALZHEIMERS-DISEASE
GARLIND A; COWBURN RF; WIEHAGER B; RAVID R; WINBLAD B; FOWLER CJ
Article: JOURNAL OF NEURAL TRANSMISSION. 1995;100(2):101-109
Characteristics of [3H]inositol(1,3,4,5)tetrakisphosphate recognition sites in human cerebellar membranes.
Garlind A; Cowburn RF; Fowler CJ
Article: JOURNAL OF NEURAL TRANSMISSION - PARKINSON'S DISEASE AND DEMENTIA SECTION. 1995;10(1):1-10
CHARACTERIZATION OF MUSCARINIC ACETYLCHOLINE-RECEPTORS IN CULTURED ADULT SKIN FIBROBLASTS - EFFECTS OF THE SWEDISH ALZHEIMERS-DISEASE APP-670/671 MUTATION ON BINDING LEVELS
VESTLING M; COWBURN RF; VENIZELOS N; LANNFELT L; WINBLAD B; ADEM A
Journal article: FEBS LETTERS. 1994;354(3):274-278
INCREASED BETA-AMYLOID RELEASE AND LEVELS OF AMYLOID PRECURSOR PROTEIN (APP) IN FIBROBLAST CELL-LINES FROM FAMILY MEMBERS WITH THE SWEDISH ALZHEIMERS-DISEASE APP670/671 MUTATION
JOHNSTON JA; COWBURN RF; NORGREN S; WIEHAGER B; VENIZELOS N; WINBLAD B; VIGOPELFREY C; SCHENK D; LANNFELT L; ONEILL C
Journal article: NEUROCHEMISTRY INTERNATIONAL. 1994;25(1):73-80
THE SIGNIFICANCE OF THE SWEDISH APP670/671 MUTATION FOR THE DEVELOPMENT OF ALZHEIMERS-DISEASE AMYLOIDOSIS
JOHNSTON J; ONEILL C; LANNFELT L; WINBLAD B; COWBURN RF
Journal article: BRAIN RESEARCH. 1994;636(2):193-201
REGIONALLY SELECTIVE ALTERATIONS IN G-PROTEIN SUBUNIT LEVELS IN THE ALZHEIMERS-DISEASE BRAIN
ONEILL C; WIEHAGER B; FOWLER CJ; RAVID R; WINBLAD B; COWBURN RF
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 1994;22(1):167-171
G-PROTEIN COUPLED SIGNAL-TRANSDUCTION SYSTEMS IN THE ALZHEIMERS-DISEASE BRAIN
ONEILL C; FOWLER CJ; WINBLAD B; COWBURN RF
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 1994;22(1):176-179
AMYLOID PRECURSOR PROTEIN GENE MUTATION AT CODON-670/671 IN FAMILIAL ALZHEIMERS-DISEASE IN SWEDEN
LANNFELT L; JOHNSTON J; BOGDANOVICH N; COWBURN R
Journal article: NEUROREPORT. 1994;5(4):405-408
BETA-AMYLOID RELATED PEPTIDES EXERT DIFFERENTIAL-EFFECTS ON [H-3] MK-801 BINDING TO RAT CORTICAL
COWBURN RF; MESSAMORE E; LI ML; WINBLAD B; SUNDSTROM E
Journal article: BRAIN RESEARCH. 1994;633(1-2):297-304
ADENYLYL-CYCLASE ACTIVITY AND G-PROTEIN SUBUNIT LEVELS IN POSTMORTEM FRONTAL-CORTEX OF SUICIDE VICTIMS
COWBURN RF; MARCUSSON JO; ERIKSSON A; WIEHAGER B; ONEILL C
Journal article: NEUROCHEMISTRY INTERNATIONAL. 1994;24(1):73-80
Characterization of [3H]inositol 1,4,5-trisphosphate binding sites in human temporal cortical and cerebellar membranes.
Garlind A; Cowburn RF; Fowler CJ
Journal article: HUMAN MOLECULAR GENETICS. 1993;2(7):1045-1046
SEQUENCING OF EXON-16 AND EXON-17 OF THE BETA-AMYLOID PRECURSOR PROTEIN GENE FAILS TO IDENTIFY NEW MUTATIONS IN SWEDISH ALZHEIMERS-DISEASE PATIENTS
JOHNSTON J; LILIUS L; AXELMAN K; COWBURN R; JOHANSSON K; VIITANEN M; WINBLAD B; LANNFELT L
Journal article: NEUROSCIENCE LETTERS. 1993;155(2):163-166
DISRUPTED BETA-1-ADRENOCEPTOR G-PROTEIN COUPLING IN THE TEMPORAL CORTEX OF PATIENTS WITH ALZHEIMERS-DISEASE
COWBURN RF; VESTLING M; FOWLER CJ; RAVID R; WINBLAD B; ONEILL C
Journal article: ACTA NEUROLOGICA SCANDINAVICA, SUPPLEMENT. 1993;88:4-6
BIOCHEMICAL PATHOLOGY AND TREATMENT STRATEGIES IN ALZHEIMERS-DISEASE - EMPHASIS ON THE CHOLINERGIC SYSTEM
WINBLAD B; MESSAMORE E; ONEILL C; COWBURN R
Journal article: NEUROSCIENCE LETTERS. 1992;141(1):16-20
PRESERVATION OF G(I)-PROTEIN INHIBITED ADENYLYL CYCLASE ACTIVITY IN THE BRAINS OF PATIENTS WITH ALZHEIMERS-DISEASE
COWBURN RF; ONEILL C; RAVID R; WINBLAD B; FOWLER CJ
Journal article: JOURNAL OF NEUROCHEMISTRY. 1992;58(4):1409-1419
ADENYLYL CYCLASE ACTIVITY IN POSTMORTEM HUMAN BRAIN - EVIDENCE OF ALTERED G-PROTEIN MEDIATION IN ALZHEIMERS-DISEASE
COWBURN RF; ONEILL C; RAVID R; ALAFUZOFF I; WINBLAD B; FOWLER CJ
Journal article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1992;225(3):195-197
Heterogeneity of NMDA receptors labelled with [3H]3-((+-)-2-carboxypiperazin-4-yl) propyl-1-phosphonic acid ([3H]CPP): receptor status in Alzheimer's disease brains.
Porter RH; Cowburn RF; Alasuzoff I; Briggs RS; Roberts PJ
Journal article: CELLULAR SIGNALLING. 1992;4(1):1-9
Brain signal transduction disturbances in neurodegenerative disorders.
Fowler CJ; Cowburn RF; O'Neill C
Journal article: ACTA NEUROLOGICA SCANDINAVICA, SUPPLEMENT. 1992;85:59-62
NEUROTRANSMITTER, RECEPTOR AND SIGNAL TRANSDUCTION DISTURBANCES IN ALZHEIMERS-DISEASE
FOWLER CJ; ONEILL C; WINBLAD B; COWBURN RF
Journal article: JOURNAL OF NEURAL TRANSMISSION. 1992;87(2):113-124
NEUROTRANSMITTER-MEDIATED INHIBITION OF POSTMORTEM HUMAN BRAIN ADENYLYL CYCLASE
GARLIND A; FOWLER CJ; ALAFUZOFF I; WINBLAD B; COWBURN RF
Journal article: NEUROPSYCHOBIOLOGY. 1992;26(1-2):33-36
GAMMA-AMINOBUTYRIC ACID-B (GABA-B) BINDING-SITES IN POSTMORTEM SUICIDE BRAINS
ARRANZ B; COWBURN R; ERIKSSON A; VESTLING M; MARCUSSON J
Journal article: NEUROSCIENCE LETTERS. 1991;133(1):15-19
PRESERVATION OF 5-HYDROXYTRYPTAMINE1A RECEPTOR G-PROTEIN INTERACTIONS IN THE CEREBRAL-CORTEX OF PATIENTS WITH ALZHEIMERS-DISEASE
ONEILL C; COWBURN RF; WIEHAGER B; ALAFUZOFF I; WINBLAD B; FOWLER CJ
Journal article: BRAIN RESEARCH. 1991;563(1-2):39-43
COUPLING OF HUMAN BRAIN CEREBRAL CORTICAL ALPHA-2-ADRENOCEPTORS TO GTP-BINDING PROTEINS IN ALZHEIMERS-DISEASE
ONEILL C; FOWLER CJ; WIEHAGER B; COWBURN RF; ALAFUZOFF I; WINBLAD B
Journal article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 1991;105(2):225-233
REGIONAL DISTRIBUTION OF SOMATOSTATIN RECEPTOR-BINDING AND MODULATION OF ADENYLYL CYCLASE ACTIVITY IN ALZHEIMERS-DISEASE BRAIN
BERGSTROM L; GARLIND A; NILSSON L; ALAFUZOFF I; FOWLER CJ; WINBLAD B; COWBURN RF
Journal article: JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY. 1991;54(8):748-749
SOMATOSTATIN RECEPTORS AND THE MODULATION OF ADENYLYL CYCLASE ACTIVITY IN ALZHEIMERS-DISEASE
COWBURN RF; FOWLER CJ; GARLIND A; ALAFUZOFF I; NILSSON L; WINBLAD B; BERGSTROM L
Journal article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1991;207(3):271-274
ENHANCED ADENYLATE-CYCLASE ACTIVITY IN NEONATALLY DOPAMINE LESIONED RATS IS RELATED TO INCREASED GS-PROTEIN COUPLING
COWBURN R; YOUNG D; LUTHMAN J
Journal article: NEUROCHEMISTRY INTERNATIONAL. 1991;18(3):389-398
CHARACTERIZATION AND REGIONAL DISTRIBUTION OF ADENYLYL CYCLASE ACTIVITY FROM HUMAN BRAIN
COWBURN RF; GARLIND A; ONEILL C; ALAFUZOFF I; WINBLAD B; FOWLER CJ
Journal article: TRENDS IN PHARMACOLOGICAL SCIENCES. 1990;11(5):183-184
Alzheimer's disease: is there a problem beyond recognition?
Fowler CJ; O'Neill C; Garlind A; Cowburn RF
Journal article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1990;188(1):51-62
EFFECT OF MONOVALENT IONS UPON G-PROTEINS COUPLING MUSCARINIC RECEPTORS TO PHOSPHOINOSITIDE HYDROLYSIS IN THE RAT CEREBRAL-CORTEX
TIGER G; BJORKLUND PE; COWBURN RF; GARLIND A; ONEILL C; WIEHAGER B; FOWLER CJ
Journal article: JOURNAL OF NEURAL TRANSMISSION - PARKINSON'S DISEASE AND DEMENTIA SECTION. 1990;2(4):295-304
AMINO-ACID-CONCENTRATIONS IN CEREBROSPINAL-FLUID AND PLASMA IN ALZHEIMERS-DISEASE AND HEALTHY CONTROL SUBJECTS
BASUN H; FORSSELL LG; ALMKVIST O; COWBURN RF; EKLOF R; WINBLAD B; WETTERBERG L
Journal article: EXPERIMENTAL BRAIN RESEARCH. 1990;83(1):85-95
NEONATAL DOPAMINE LESION IN THE RAT RESULTS IN ENHANCED ADENYLATE-CYCLASE ACTIVITY WITHOUT ALTERING DOPAMINE RECEPTOR-BINDING OR DOPAMINE-MONOPHOSPHATE-REGULATED AND ADENOSINE 3'-5'-MONOPHOSPHATE-REGULATED PHOSPHOPROTEIN (DARPP-32) IMMUNOREACTIVITY
LUTHMAN J; LINDQVIST E; YOUNG D; COWBURN R
Journal article: JOURNAL OF NEUROCHEMISTRY. 1989;52(6):1843-1853
Enhancement by potassium of carbachol-stimulated inositol phospholipid breakdown in rat cerebral cortical miniprisms: comparison with other depolarising agents.
Tiger G; Björklund PE; Cowburn RF; Fowler CJ
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Meeting abstract: BIOCHIMICA ET BIOPHYSICA ACTA - BIOENERGETICS. 2008;1777:S55
Altered mitochondrial dynamics caused by loss of PTEN-induced kinase 1 function, associated with recessive parkinsonism, are reversed by downregulation of Dynamin-related protein 1
Thomas KJ; Sandebring A; Beilina A; van der Brug M; Cleland MM; Zambrano I; Miller DW; Unger C; Cowburn R; Youle R; Behbahani H; Cedazo-Minguez A; Cookson MR
Conference publication: THE FEBS JOURNAL. 2007;274:167
Role of presenilins in signal transduction pathways and cell death in Alzheimer's disease
Popescu BO; Ankarcrona M; Cedazo-Minguez A; Hansson CA; Popescu LM; Cowburn RF; Winblad B
Conference publication: INTERNATIONAL PSYCHOGERIATRICS. 2005;17:204-205
Presenilin dependence of phospholipase C regulation
Dehvari N; Cedazo-Minguez A; Winblad B; Cowburn R
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15:S350
Apolipoprotein E and presenilin regulation of cellular signalling
Cowburn R; Cedazo-Minguez A
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:s549
Localization of nicastrin/presenilin/APH-1/PEN-2 complexes to mitochondria
Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:S174
The relationship between PTEN and phospho-AKT in Alzheimer's disease
Rickle A; Bogdanovic N; Nishimura T; Volkmann I; Winblad B; Cowburn R
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:S560
Presenilin mediated regulation of PTEN expression and breakdown in SH-SY5Y neuroblastoma cells following proapoptotic stress
Nishimura T; Rickle A; Ito A; Winblad B; Cowburn RF
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:S541-S542
Beta-amyloid oxidation of thioredoxin and glutaredoxin.: A possible link between oxidative stress and apoptosis in Alzheimer's disease
Akterin S; Miranda-Vizuete A; Winblad B; Cowburn RF; Cedazo-Mínguez A
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:s469
Effects of wild-type and mutant parkin on stress responses in SH-SY5Y neuroblastoma cells
Vestling M; Sunesson L; Cowburn RF
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:S90
Involvement of aberrant regulation of PI3K and MAPK cascades in AD Tau phosphorylation
Pei JJ; An WL; Cowburn RF; Grundke-Iqbal I; Iqbal K; Winblad B
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:S424-S425
Association of p70 S6 kinase with neurofibrillary degeneration Alzheimer's disease
An WL; Cowburn RF; Bjorkdahl C; Braak H; Alafuzoff I; Iqbal K; Grundke-Iqbal I; Winblad B
Corrigendum: AMERICAN JOURNAL OF PATHOLOGY. 2003;163(6):2645
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease (vol 163, pg 591, 2003)
An WL; Cowburn RF; Li L; Braak H; Alafuzoff I; Iqbal K; Grundke-Iqal I; Winbald B; Pei JJ
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S401-S402
Apolipoprotein E and beta amyloid peptide regulation of glycogen synthase kinase-3 beta
Cedazo-Minguez A; Wiehager B; Pei JJ; Cowburn RF
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S215
The presenilin-1 δE9 mutation gives enhanced phospholipase C activity and a resultant increase in intracellular calcium concentrations
Popescu BO; Cedazo-Minguez A; Ankarcrona M; Nishimura T; Cowburn RF
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S180
Decreased Gα_i-subunit levels in hippocampus of brains staged for Alzheimer's disease neurofibrillary pathology
García-Jiménez A; Fastbom J; Cowburn R; Ohm TG
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S214-S215
Distribution of presenilin-1 and-2 and their relation to notch receptors and ligands in human foetal CNS
Kostyszyn B; Cowburn R; Seiger A; Sundstrom E; Kjaeldgaard A
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S500
The relationship between abnormal hyperphosphorylated tau, activated p38 kinase, and the proteolytic system in Alzheimer's disease brain
An WL; Cowburn RF; Winblad B; Alafuzoff I
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S499-S500
Neurofilament changes preceed tau phosphorylation
Nakamura Y; Kishimoto T; Yoshino H; Cowburn R; Winblad B; Bodanovic N; Takeda M
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S498
Mitogen-activated protein kinases ERK1/2 and MEK1/2 are regulated by protein phosphatase 2A in rat brain: Implications in Alzheimer's disease
Pei JJ; An WL; Cowburn RF; Winblad B; Gong CX; Grundke-Iqbal I; Iqbal K
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S398
Comparison of the expression of amyloid precursor protein-like proteins in human postmortem brain tissue by quantitative RT-PCR
Toro VC; Schultzberg M; Cowburn R; Iverfeldt K
Conference publication: JOURNAL OF ALZHEIMER'S DISEASE. 2002;4(1):49
Mitogen activated protein kinase (MAPK), MAPK kinase and P70S6 kinase are regulated by protein phosphatase 2A in rat brain: Implication in neurofibrillary degeneration in Alzheimer's disease
Pei JJ; Gong CX; An WL; Cowburn RF; Winblad B; Grundke-Iqbal I; Iqbal K
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2002;12:S56
Mutated presenilin 1 alters cholinergic signaling in neuroblastoma cells
Popescu BO; Cedazo-Mínguez A; Ankarcrona M; Cowburn RF
Conference publication: THE FASEB JOURNAL. 2002;16(4):A505
Ca²⁺ stores and capacitative Ca²⁺ entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation.
Smith IF; Boyle JP; Vaughan PFT; Pearson HA; Cowburn R; Peers C
Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2001;5(3):254-266
Apolipoprotein E:: a major piece in the Alzheimer's disease puzzle
Cedazo-Mínguez A; Cowburn RF
Published conference paper: BIOCHEMICAL SOCIETY SYMPOSIUM. 2001;67(67):177-194
Dysfunctional intracellular calcium homoeostasis: a central cause of neurodegeneration in Alzheimer's disease
O'Neill C; Cowburn RF; Bonkale WL; Ohm TG; Fastbom J; Carmody M; Kelliher M
Published conference paper: BIOCHEMICAL SOCIETY SYMPOSIUM. 2001;67(67):163-175
Receptor-G-protein signalling in Alzheimer's disease
Cowburn RF; O'Neill C; Bonkale WL; Ohm TG; Fastbom J
Published conference paper: BIOCHEMICAL SOCIETY SYMPOSIUM. 2001;67(67):121-129
Apolipoprotein E and βA4-amyloid:: signals and effects
Ohm TG; Hamker U; Cedazo-Minguez A; Röckl W; Scharnagl H; März W; Cowburn R; Müller W; Meske V
Book chapter: MENTAL DISORDERS IN THE ELDERLY: NEW THERAPEUTIC APPROACHES: INTERNATIONAL ACADEMY FOR BIOMEDICAL AND DRUG RESEARCH. 1998;p. 110-116
Signal Transduction Mechanisms in Alzheimer´s Disease
Fastbom J; Ohm TG; Bonkale WL; Kurumatani T; Winblad B; Cowburn RF
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1996;786:294-304
Receptor-effector coupling dysfunctions in Alzheimer's disease.
Fowler CJ; Garlind A; O'Neill C; Cowburn RF
Published conference paper: ACTA NEUROLOGICA SCANDINAVICA, SUPPLEMENT. 1996;168:77-86
The neurochemistry of Alzheimer's disease.
Blennow K; Cowburn RF
Published conference paper: ACTA NEUROLOGICA SCANDINAVICA, SUPPLEMENT. 1996;165:25-32
Neurotransmitters, signal transduction and second-messengers in Alzheimer's disease.
Cowburn RF; Fowler CJ; O'Neill C
Letter: TRENDS IN NEUROSCIENCES. 1995;18(11):483-484
Membrane alterations in Alzheimer's disease and aging.
Cowburn RF; O'Neill C; Fowler CJ
Letter: NATURE GENETICS. 1995;11(2):219-222
THE STRUCTURE OF THE PRESENILIN-1 (S182) GENE AND IDENTIFICATION OF 6 NOVEL MUTATIONS IN EARLY-ONSET AD FAMILIES
CLARK RF; HUTTON M; FULDNER RA; FROELICH S; KARRAN E; TALBOT C; CROOK R; LENDON C; PRIHAR G; HE C; KORENBLAT K; MARTINEZ A; WRAGG M; BUSFIELD F; BEHRENS MI; MYERS A; NORTON J; MORRIS J; MEHTA N; PEARSON C; LINCOLN S; BAKER M; DUFF K; ZEHR C; PEREZTUR J; HOULDEN H; RUIZ A; OSSA J; LOPERA F; ARCOS M; MADRIGAL L; COLLINGE J; HUMPHREYS C; ASHWORTH A; SARNER S; FOX N; HARVEY R; KENNEDY A; ROQUES P; CLINE RT; PHILLIPS CA; VENTER JC; FORSELL L; AXELMAN K; LILIUS L; JOHNSTON J; COWBURN R; VIITANEN M; WINBLAD B; KOSIK K; HALTIA M; POYHONEN M; DICKSON D; MANN D; NEARY D; SNOWDEN J; LANTOS P; LANNFELT L; ROSSOR M; ROBERTS GW; ADAMS MD; HARDY J; GOATE A
Book chapter: SIGNAL TRANSDUCTION MECHANISMS: DEVELOPMENTS IN MOLECULAR AND CELLULAR BIOCHEMISTRY. 1995;p. 287-292
Disturbances in signal transduction mechanisms in Alzheimer’s disease
Fowler CJ; Cowburn RF; Garlind A; Winblad B; O’Neill C
Conference publication: NEUROBIOLOGY OF AGING. 1994;15:S71
AMYLOID PRECURSOR PROTEIN EXPRESSION AND BETA-AMYLOID RELEASE IN FIBROBLAST CELL-LINES OBTAINED FROM FAMILY MEMBERS WITH THE SWEDISH APP670/671 MUTATION
JOHNSTON J; COWBURN R; WIEHAGER B; NORGREN S; LANNFELT L; VIGOPELFREY C; SCHENK D; CITRON M; SELKOE D; ONEILL C
Conference publication: NEUROBIOLOGY OF AGING. 1994;15:S18
DIFFERENTIAL-EFFECTS OF BETA-AMYLOID PEPTIDES ON RADIOLIGAND BINDING TO THE NMDA RECEPTOR COMPLEX
COWBURN RF; TRIEF E; MESSAMORE E; LI ML; WINBLAD B; SUNDSTROM E
Conference publication: NEUROBIOLOGY OF AGING. 1994;15:S126
SELECTIVE LOSS OF INOSITOL(1,4,5)TRISPHOSPHATE (IP3) BUT NOT INOSITOL(1,3,4,5)TETRAKIPHOSPHATE (IP4) RECEPTOR-SITES IN THE ALZHEIMERS-DISEASE BRAIN
GARLIND A; COWBURN RF; FORSELL L; WINBLAD B; FOWLER CJ
Conference publication: NEUROBIOLOGY OF AGING. 1994;15:S16-S17
BINDING-STUDIES OF MUSCARINIC CHOLINERGIC RECEPTORS IN CULTURED ADULT SKIN FIBROBLASTS
VESTLING M; VENIZELOS N; JOHNSTON J; COWBURN R; LANNFELT L; WINBLAD B; ADEM A
Book chapter: TROPHIC REGULATION OF THE BASAL GANGLIA. 1994;p. 479-501
31 Plasticity Responses After Neonatal Dopamine Lesions Induced With 6-Hydroxydopamine
LUTHMAN J; COWBURN R; DE SIMONI MG; RENYI L
Book chapter: ALZHEIMER DISEASE: ADVANCES IN ALZHEIMER DISEASE THERAPY. 1994;p. 485-492
Therapeutic Strategies in Alzheimer’s Disease
Wahlund L-O; Cowburn RF; Winblad B; Lannfelt L
Book chapter: NEUROPSYCHOPHARMACOLOGY. 1990;p. 668-674
Neurotransmitter Function in Post-Mortem Human Brain: An Overview
Fowler CJ; Cowburn RF; Hardy JA; Wester P; Winblad B
Book chapter: AMYLOID PROTEIN PRECURSOR IN DEVELOPMENT, AGING AND ALZHEIMER’S DISEASE: RESEARCH AND PERSPECTIVES IN ALZHEIMER'S DISEASE. 1981;p. 209-215
APP Gene Mutations in Familial Alzheimer’s Disease in Sweden
Lannfelt L; Bogdanovic N; Johnston J; Cowburn R
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