Renske Altena
Om mig
Dr. Renske Altena is a medical oncologist specializing in the treatment of breast and thyroid cancer with a special interest in radiopharmaceutical treatment. She serves as an Associate Professor in Oncology at the Department of Oncology-Pathology at Karolinska Institutet and is a senior consultant and lead physician at Docrates Cancer Center.
She completed her medical degree at the University of Groningen in the Netherlands in 2006, followed by a Ph.D. in Medical Sciences in 2011. She has held various medical positions in both the Netherlands and Sweden, becoming a consultant oncologist in Sweden in June 2018.
Renske serves various positions of trust, such as the executive board of Cancer Research KI, Cancerklinikens Jubileumfond in Gothenburg and the Ethical Review Authority in Stockholm. She is active in educational activities and outreach for the Swedish Oncological society, SOF.
Forskningsbeskrivning
Dr. Altena's research focuses on clinical trials aimed at improving cancer patient management. A key aspect of her work involves investigating radiopharmaceuticals for cancer visualization and treatment. This is conducted in close collaboration with multidisciplinary experts, including radiopharmacists, nuclear medicine physicians, and medical physicists. Within this team, she leads a work package in a VINNOVA-funded national project, conducting a clinical trial on precision imaging for patients with HER2-low metastatic breast cancer.
Additionally, Dr. Altena is actively involved in several projects exploring the role of physical exercise in cancer treatment and management. Notable examples include the Neo-ACT and EFFECT trials.
Undervisning
Over 200 hours teaching to undergraduate and doctoral students
Courses - KI's Introductory Course for Doctoral Supervisors (2022); Grundläggande Högskolpedagogik (2019); Teach the Teacher (2012),
Artiklar
- Journal article: JOURNAL OF NUCLEAR MEDICINE. 2025;66(9):1500-1501Skarping I; Tran T; Axelsson R; Altena R
- Article: INTERNATIONAL JOURNAL OF CANCER. 2025;157(3):490-503Schmidt ME; Hiensch AE; Depenbusch J; Monninkhof EM; Belloso J; Clauss D; Gunasekara N; Trevaskis M; Rundqvist H; Wiskemann J; Mueller J; Sweegers MG; Schneweiss A; Altena R; Kufel-Grabwska J; Bijlsma RM; van Leeuwen-Snoeks L; Huinink DTB; Sonke G; Brandner S; Savas P; Antill Y; White M; Ancizar N; van Der Wall E; Aaronson NK; Senkus E; Urruticoechea A; Zopf EM; Bloch W; Stuiver MM; Wengstroem Y; May AM; Steindorf K
- Journal article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2025;52(9):3073-3074Altena R; Tran TA; Tzortzakakis A
- Article: JOURNAL OF CANCER SURVIVORSHIP. 2025;:1-16Kotte M; Bolam KA; Altena R; Cormie P; Wengstrom Y; Mijwel S
- Article: JOURNAL OF CLINICAL ONCOLOGY. 2025;43(11):1325-1336Schouten AEM; Hiensch AE; Frederix GWJ; Monninkhof EM; Schmidt ME; Clauss D; Gunasekara N; Belloso J; Trevaskis M; Rundqvist H; Wiskemann J; Mueller J; Sweegers MG; Fremd C; Altena R; Bijlsma RM; Sonke G; Lahuerta A; Mann GB; Francis PA; Richardson G; Malter W; Kufel-Grabowska J; van der Wall E; Aaronson NK; Senkus E; Urruticoechea A; Zopf EM; Bloch W; Stuiver MM; Wengstrom Y; Steindorf K; van der Meulen MP; May AM
- Article: WORLD JOURNAL OF SURGERY. 2025;49(4):985-996ten Hoor MBC; Lin JF; Metman MJH; Schaap PMR; Links TP; Altena R; van Ginhoven TM; Zandee WT; Engelsman AF; Kruijff S
- Article: EJNMMI RESEARCH. 2025;15(1):12Bjareback A; Jonmarker O; Tzortzakakis A; Jussing E; Li C; Altena R; Hindorf C; Orlova A; Axelsson R; Tran TA
- Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2025;43(5):513-523Turner N; Saura C; Aftimos P; van den Tweel E; Oesterholt M; Koper N; Colleoni M; Kaczmarek E; Punie K; Song X; Armstrong A; Bianchi G; Stradella A; Ladoire S; Lim JSJ; Quenel-Tueux N; Tan TJ; Escrivá-de-Romaní S; O'Shaughnessy J; TULIP Trial Investigators
- Article: NATURE MEDICINE. 2024;30(10):2957-2966Hiensch AE; Depenbusch J; Schmidt ME; Monninkhof EM; Pelaez M; Clauss D; Gunasekara N; Zimmer P; Belloso J; Trevaskis M; Rundqvist H; Wiskemann J; Mueller J; Sweegers MG; Fremd C; Altena R; Gorecki M; Bijlsma R; van Leeuwen-Snoeks L; ten Bokkel Huinink D; Sonke G; Lahuerta A; Mann GB; Francis PA; Richardson G; Malter W; van der Wall E; Aaronson NK; Senkus E; Urruticoechea A; Zopf EM; Bloch W; Stuiver MM; Wengstrom Y; Steindorf K; May AM
- Journal article: ANNALS OF ONCOLOGY. 2024;35:s402-s403Altena R; Tzortzakakis A; Blomgren A; Jussing E; Ekman S; Tran T; Axelsson R; Bergh J
- Article: EJSO. 2024;50(6):108031Vasileva-Slaveva M; Morales-Espinosa D; Puccini A; Meissner M; Milic M; Lamberti G; Altena R
- Journal article: CANCER RESEARCH. 2024;84(9_Supplement):gs02-10-gs02-10May A; Hiensch A; Depenbusch J; Schmidt M; Monninkhof E; Pelaez M; Clauss D; Zimmer P; Belloso J; Trevaskis M; Rundqvist H; Wiskemann J; Muller J; Fremd C; Altena R; Kufel-Grabowska J; Bijlsma R; van Leeuwen-Snoeks L; Bokkel-Huinink DT; Sonke G; Mann B; Francis P; Richardson G; Álvarez I; Malter W; Van der Wall E; Aaronson N; Senkus E; Urriticoechea A; Zopf E; Bloch W; Stuiver M; Wengström Y; Steindorf K
- Journal article: CANCER RESEARCH. 2024;84(9):po1-19-06-po1-19-06de Boniface J; Ringborg CH; Altena R; Wengstrom Y
- Journal article: JOURNAL OF CLINICAL EXERCISE PHYSIOLOGY. 2024;13(s2):339Zopf DE; Hiensch DAE; Depenbusch DJ; Schmidt DME; Monninkhof DEM; Pelaez M; Clauss DD; Zimmer DP; Belloso J; Trevaskis M; Rundqvist H; Wiskemann J; Mueller J; Fremd C; Altena R; Kufel-Grabowska J; Bijlsma R; van Leeuwen-Snoeks L; ten Bokkel Huinink D; Sonke G; Lahuerta A; Mann B; Francis P; Richardson G; Malter W; van der Wall E; Aaronson NK; Senkus E; Urruticoechea A; Bloch W; Stuiver MM; Wengstrom Y; Steindorf K; May AM
- Article: JOURNAL OF NUCLEAR MEDICINE. 2024;65(5):700-707Altena R; af Buren S; Blomgren A; Karlsson E; Tzortzakakis A; Brun N; Moein MM; Jussing E; Frejd FY; Bergh J; Tran TA; Hartman J; Axelsson R
- Article: EJNMMI RADIOPHARMACY AND CHEMISTRY. 2023;8(1):41Jussing E; Ferrat M; Moein MM; Alfredeen H; Tegnebratt T; Bratteby K; Samen E; Feldwisch J; Altena R; Axelsson R; Tran TA
- Journal article: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:108529Jussing E; Alfredéen H; Moein MM; Tegnebratt T; Bratteby K; Samen E; Altena R; Axelsson R; Tran T
- Journal article: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:108455Bratteby K; Smertinaite L; Omer S; Lu L; Milton S; Jussing E; Siikanen J; Samen E; Axelsson R; Foukakis T; Altena R; Tran T
- Journal article: JOURNAL OF NUCLEAR MEDICINE. 2023;64(11):1841Altena R; af Buren S; Tran T; Axelsson R
- Journal article: ANNALS OF ONCOLOGY. 2023;34:s384af Buren S; Axelsson R; Jussing E; Karlsson M; Blomgren A; Brun N; Frejd FY; Tran TA; Altena R
- Article: TRIALS. 2023;24(1):116Kotte M; Bolam KA; Mijwel S; Altena R; Cormie P; Wengstrom Y
- Article: ANNALS OF ONCOLOGY. 2022;33(12):1250-1268Geyer CEJ; Garber JE; Gelber RD; Yothers G; Taboada M; Ross L; Rastogi P; Cui K; Arahmani A; Aktan G; Armstrong AC; Arnedos M; Balmana J; Bergh J; Bliss J; Delaloge S; Domchek SM; Eisen A; Elsafy F; Fein LE; Fielding A; Ford JM; Friedman S; Gelmon KA; Gianni L; Gnant M; Hollingsworth SJ; Im S-A; Jager A; Lakhani SR; Janni W; Linderholm B; Liu T-W; Loman N; Korde L; Loibl S; Lucas PC; Marme F; de Duenas EM; McConnell R; Phillips K-A; Piccart M; Rossi G; Schmutzler R; Senkus E; Shao Z; Sharma P; Singer CF; Spanic T; Stickeler E; Toi M; Traina TA; Viale G; Zoppoli G; Park YH; Yerushalmi R; Yang H; Pang D; Jung KH; Mailliez A; Fan Z; Tennevet I; Zhang J; Nagy T; Sonke GS; Sun Q; Parton M; Colleoni MA; Schmidt M; Brufsky AM; Razaq W; Kaufman B; Cameron D; Campbell C; Tutt ANJ; Johannsson OT
- Article: LAKARTIDNINGEN. 2022;119:22093Altena R; Tzortzakakis A; Sörensen J; Y Frejd F; Bergh J; Axelsson R
- Article: PLOS ONE. 2022;17(10):e0274804de Boniface J; Altena R; Ringborg CH; Bolam KA; Wengstrom Y
- Article: LAKARTIDNINGEN. 2022;119:22070Rundqvist H; Johnson A; Onerup A; Altena R; Wengström Y
- Article: EUROPEAN JOURNAL OF CANCER CARE. 2022;31(5):e13626Altena R; Gernaat SAM; Wilking U; Kiani NA; Johnsson A; Hedayati E
- Journal article: CANCER RESEARCH. 2022;82(4):p3-18-03-p3-18-03Wang K; Duinmeijer A; Matikas A; Altena R; Johansson H; Fredholm H; Foukakis T
- Article: CARDIO-ONCOLOGY. 2021;7(1):7Ansund J; Mijwel S; Bolam KA; Altena R; Wengstrom Y; Rullman E; Rundqvist H
- Article: EUROPEAN JOURNAL OF CANCER CARE. 2021;30(1):e13353Gernaat SAM; Johnsson A; Altena R; Wilking U; Hedayati E
- Article: CARDIO-ONCOLOGY. 2020;6(1):16Hedayati E; Papakonstantinou A; Mansson-Broberg A; Bergh J; Hubbert L; Altena R
- Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7S):809Mijwel S; Wiggenraad F; Bolam K; Altena R; Wengström Y
- Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2020;38(15_suppl):e14121Elham H; Gernaat SAM; Johnsson A; Wilking UM; Altena R
- Journal article: EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES. 2020;6(2):180Hedayati E; Papakonstantinou A; Gernaat SAM; Altena R; Brand JS; Alfredsson J; Bhoo-Pathy N; Herrmann J; Linde C; Dahlstrom U; Bergh J; Hubbert L
- Article: EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES. 2020;6(2):147-155Hedayati E; Papakonstantinou A; Gernaat SAM; Altena R; Brand JS; Alfredsson J; Bhoo-Pathy N; Herrmann J; Linde C; Dahlstrom U; Bergh J; Hubbert L
- Article: ENDOCRINE PATHOLOGY. 2020;31(1):77-83Stenman A; Hellgren LS; Jatta K; Hysek M; Zemmler M; Altena R; Nilsson I-L; Branstrom R; Zedenius J; Juhlin CC
- Article: INTEGRATIVE CANCER THERAPIES. 2020;19:1534735420905003Wiggenraad F; Bolam KA; Mijwel S; van der Wall E; Wengstrom Y; Altena R
- Article: JAMA ONCOLOGY. 2016;2(8):1030-1037Boekhout AH; Gietema JA; Kerklaan BM; van werkhoven ED; Altena R; Honkoop A; Los M; Smit WM; Nieboer P; Smorenburg CH; Mandigers CMPW; van der Wouw AJ; Kessels L; van der Velden AWG; Ottevanger PB; Smilde T; de Boer J; van Veldhuisen DJ; Kema IP; de Vries EGE; Schellens JHM
- Article: ONCOLOGIST. 2016;21(8):995-1001den Hollander MW; Westerink N-DL; Lubberts S; Bongaerts AHH; Wolf RFE; Altena R; Nuver J; Oosting SF; de Vries EGE; Walenkamp AME; Meijer C; Gietema JA
- Article: EUROPEAN JOURNAL OF CANCER. 2016;63:180-188Lubberts S; Boer H; Altena R; Meijer C; van Roon AM; Zwart N; Oosting SF; Kamphuisen PW; Nuver J; Smit AJ; Mulder AB; Lefrandt JD; Gietema JA
- Article: EUROPEAN JOURNAL OF CANCER. 2016;54:104-111Boer H; Westerink N-DL; Altena R; Nuver J; Dijck-Brouwer DAJ; van Faassen M; Klont F; Kema IP; Lefrandt JD; Zwart N; Boezen HM; Smit AJ; Meijer C; Gietema JA
- Article: ANNALS OF ONCOLOGY. 2015;26(11):2305-2310Boer H; Proost JH; Nuver J; Bunskoek S; Gietema JQ; Geubels BM; Altena R; Zwart N; Oosting SF; Vonk JM; Lefrandt JD; Uges DRA; Meijer C; de Vries EGE; Gietema JA
- Article: PLOS ONE. 2015;10(1):e0115372Altena R; Fehrmann RSN; Boer H; de Vries EGE; Meijer C; Gietema JA
- Journal article: TALANTA. 2014;121:9-17Vu DH; Koster RA; Bolhuis MS; Greijdanus B; Altena RV; Nguyen DH; Brouwers JRBJ; Uges DRA; Alffenaar JWC
- Article: ANNALS OF ONCOLOGY. 2013;24(3):749-755de Haas EC; Altena R; Boezen HM; Zwart N; Smit AJ; Bakker SJL; van Roon AM; Postma A; Wolffenbuttel BHR; Hoekstra HJ; van Leeuwen FE; Sleijfer DT; Gietema JA
- Journal article: FUTURE ONCOLOGY. 2013;9(2):137-140Altena R; van Veldhuisen DJ
- Journal article: ANNALS OF ONCOLOGY. 2012;23(8):2206-2208Altena R; Gietema JA; van Veldhuisen DJ; Reyners AKL
- Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(15_suppl):e15035Altena R; Fehrmann RSN; Boer H; de Vries EGE; Meijer C; Gietema JA
- Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(15_suppl):4528Boer H; Proost JH; Nuver J; Bunskoek S; Gietema JQ; Geubels BM; Altena R; Zwart N; Oosting S; Uges DRA; Meijer C; De Vries E; Gietema JA
- Article: ANNALS OF ONCOLOGY. 2011;22(10):2286-2293Altena R; Hummel YM; Nuver J; Smit AJ; Lefrandt JD; de Boer RA; Voors AA; van den Berg MP; de Vries EGE; Boezen HM; Gietema JA
- Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2010;28(15_suppl):tps108Altena R; Boekhout AH
- Journal article: EUROPEAN JOURNAL OF ONCOLOGY NURSING. 2010;14:s2Bunskoek S; Manenschijn A; Tuinier W; Altena R
- Article: BRITISH JOURNAL OF CANCER. 2009;100(12):1861-1866Altena R; de Haas EC; Nuver J; Brouwer CAJ; van den Berg MP; Smit AJ; Postma A; Sleijfer DT; Gietema JA
- Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2009;27(15_suppl):e16009Altena R; De Haas EC; Tibbe AG; Smit AJ; van Roon A; Meijer C; Boezen MH; van der Meer J; Sleijfer DT; Gietema JA
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Alla övriga publikationer
- Conference publication: ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. 2024;20:87-88Rundqvist H; Joernaker G; Clauss D; Trevaskis M; Hiensch AE; Schmidt ME; Monninkhof EM; Zimmer P; Belloso J; Heyrman E; Gonzalo RF; Wiskemann J; Mueller J; Altena R; Mann B; Francis P; Richardson G; Antill Y; White M; Savas P; van der wall E; Aaronson NK; Senkus E; Urruticoechea A; Stuiver MM; Steindorf K; Bloch W; Wengstrom Y; May AM; Zopf EM
- Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2024;51:S823-S824Tzortzakakis A; Bjareback A; Hindorf C; Buren SA; Jussing E; Tolmachev V; Varasteh Z; Moein M; Tran T; Axelsson R; Orlova A; Altena R
- Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2024;51:S803Bjareback A; Tzortzakakis A; Estenberg U; Axelsson R; Jonmarker O; Altena R; Li C; Moein M; Orlova A; Tran TA; Hindorf C
- Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2024;51:S670Kistner A; Sadus T; Nilsson J; Altena R; Larsson M; Hindorf C
- Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2024;51:S39-S40Bratteby K; Jussing E; Ferrat M; Bylund L; Tegenbratt T; Garousi J; Frejd F; Furebring T; Frank P; Altena R; Mortensen A; Nestor M; Tran TTA
- Review: BIOMEDICINES. 2024;12(5):1088Eissler N; Altena R; Alhuseinalkhudhur A; Bragina O; Feldwisch J; Wuerth G; Loftenius A; Brun N; Axelsson R; Tolmachev V; Sorensen J; Frejd FY
- Preprint: PREPRINTS.ORG. 2024Eissler N; Altena R; Alhuseinalkhudhur A; Bragina O; Feldwisch J; Wuerth G; Loftenius A; Brun N; Axelsson R; Tolmachev V; Sörensen J; Frejd FY
- Review: LAKARTIDNINGEN. 2024;121:23108Altena R; Nilsson M; Bergman V; Dahlberg J; Juhlin CC; Zedenius J
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2024;47:199Depenbusch J; Hiensch AE; Schmidt M; Monninkhof EM; Puente MP; Clauss D; Zimmer P; Belloso J; Trevaskis M; Rundqvist H; Wiskemann J; Mueller J; Fremd C; Altena R; Kufel-Grabowska J; Bijlsma RM; van Leeuwen-Snoeks L; Ten Bokkel-Huinink D; Sonke G; Mann B; Francis P; Richardson G; Malter W; Lopez IMA; van der Wall E; Aaronson N; Senkus E; Urruticoechea A; Zopf E; Bloch W; Stuiver MM; Wengstrom Y; May A; Steindorf K
- Preprint: RESEARCH SQUARE. 2023Jussing E; Ferrat M; Moein MM; Alfredéen H; Tegnebratt T; Bratteby K; Samén E; Feldwisch J; Altena R; Axelsson R; Tran TA
- Review: EJNMMI RESEARCH. 2023;13(1):43Altena R; Tzortzakakis A; Buren SA; Tran TA; Frejd FY; Bergh J; Axelsson R
- Conference publication: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:S46Bratteby K; Smertinaite L; Omer S; Lu L; Milton S; Jussing E; Siikanen J; Samen E; Axelsson R; Foukakis T; Altena R; Tran T
- Conference publication: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:S99-S100Jussing E; Alfredeen H; Moein MM; Tegnebratt T; Bratteby K; Samen E; Altena R; Axelsson R; Tran T
- Review: CANCERS. 2022;14(19):4665Altena R; Bajalica-Lagercrantz S; Papakonstantinou A
- Preprint: RESEARCH SQUARE. 2021Altena R; Gernaat SAM; Wilking U; Kiani N; Johnsson A; Hedayati E
- Review: CARDIO-ONCOLOGY. 2021;7(1):20Altena R; Hubbert L; Kiani NA; Wengstrom Y; Bergh J; Hedayati E
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7):809Mijwel S; Wiggenraad F; Bolam K; Altena R; Wengstrom Y
- Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2020;38(15)Elham H; Gernaat SAM; Johnsson A; Wilking UM; Altena R
- Conference publication: ANNALS OF ONCOLOGY. 2020;31:S54Bernell E; Duinmeijer A; Altena R; Foukakis T; Fredholm H
- Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2015;33(15):e15556Lubberts S; Boer H; Altena R; Meijer C; van Roon AM; Zwart N; Oosting S; Kamphuisen PW; Nuver J; Smit AJ; Mulder AB; Lefrandt JD; Gietema JA
- Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2015;33(15):4540Westerink N-DL; Lubberts S; den Hollander MW; Bongaerts AHH; Wolf RFE; Altena R; Nuver J; Oosting S; De Vries E; Walenkamp AME; Meijer C; Gietema JA
- Letter: HAEMATOLOGICA. 2014;99(2):e26-e27Altena R; van Roon E; Folkeringa R; de Wit H; Hoogendoorn M
- Review: ANNALS OF ONCOLOGY. 2013;24(4):878-888Beyer J; Albers P; Altena R; Aparicio J; Bokemeyer C; Busch J; Cathomas R; Cavallin-Stahl E; Clarke NW; Classen J; Cohn-Cedermark G; Dahl AA; Daugaard G; De Giorgi U; De Santis M; De Wit M; De Wit R; Dieckmann KP; Fenner M; Fizazi K; Flechon A; Fossa SD; Germa Lluch JR; Gietema JA; Gillessen S; Giwercman A; Hartmann JT; Heidenreich A; Hentrich M; Honecker F; Horwich A; Huddart RA; Kliesch S; Kollmannsberger C; Krege S; Laguna MP; Looijenga LHJ; Lorch A; Lotz JP; Mayer F; Necchi A; Nicolai N; Nuver J; Oechsle K; Oldenburg J; Oosterhuis JW; Powles T; Rajpert-De Meyts E; Rick O; Rosti G; Salvioni R; Schrader M; Schweyer S; Sedlmayer F; Sohaib A; Souchon R; Tandstad T; Winter C; Wittekind C
- Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2011;29(15):4631Altena R; Boer H; Meijer C; Nuver J; van Roon AM; Zwart N; De Vries E; Lefrandt JD; Smit AJ; Gietema JA
- Review: LANCET ONCOLOGY. 2009;10(4):391-399Altena R; Perik PJ; van Veldhuisen DJ; de Vries EGE; Gietema JA
- Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2008;26(15):5088Altena R; Nuver J; van den Berg MP; Smit AJ; Sleijfer DT; Gietema JA
- Preprint: MEDRXIV.Altena R; Tran TA; Kjällquist U; Karlsson M; Siikanen J; Jussing E; Tzortzakakis A; Jonmarker O; Axelsson R; Bergh J
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Forskningsbidrag
- Swedish Research Council1 January 2024 - 31 December 2027Triple negative breast cancer (TNBC) and metastatic urothelial cancer (mUC) have poor prognoses with low survival rates. Treatment options for these metastatic solid tumors have been expanded through the introduction of checkpoint inhibitors (such as atezolizumab and pembrolizumab), systemic chemotherapy, or antibody-drug conjugates (ADC) directed against cell surface proteins like TROP-2 (Trophoblast cell surface antigen 2).A promising approach is to develop radiotheranostics using radiolabelled novel antibodies that target TROP-2 expression, a protein highly expressed in both TNBC and mUC. The concept utilizes a TROP-2 specific monoclonal antibody, radiolabelled with alpha- or beta particle radiation for therapy or radiolabelled with gamma och positron radiation for diagnostics. This approach delivers therapeutic quantities of radioactivity specifically to the tumor cells while sparing normal tissues. The same antibody, radiolabelled with diagnostic radionuclides, tumors are detected by imaging modalities that are currently used in clinical practice. We believe that targeting TROP-2 with radiotheranostics might provide an effective treatment option with a favourable toxicity-benefit balance, and might be a better option for patients who do not respond to ADC or other later line systemic therapies. The project is currently in preclinical development and has high translational feasibility into patients within 4-5 years.
- Swedish Research Council1 December 2021 - 30 November 2025Neoadjuvant chemotherapy (NACT) is increasingly used in breast cancer. The best proof of NACT efficacy is pathological complete response (pCR), i.e. the absence of invasive tumour on post-NACT surgical histopathology. While it is known that physical exercise can help patients to better tolerate and complete often harsh cancer treatments, it is an emerging area of research to understand if and how exercise exerts anti-tumour effects and improves oncological outcomes. The main aim of the Neo-ACT trial is to examine if a physical exercise intervention during NACT can increase pCR rates in breast cancer. Secondary aims are patient-related outcomes (health-related quality of life, physical activity), physiological outcomes (muscle strength, cardiorespiratory fitness), cancer treatment-related toxicities (cognitive dysfunction, chemotherapy completion rates) and long-term sick leave. Furthermore, the trial will explore how physical exercise affects anti-tumoral mechanisms inherent to therapy or host by hypothesis-generating translational analyses.712 patients with primary invasive breast cancer will be randomized to either a supervised intervention of high-intensity interval and resistance training during NACT, supported by an exercise app, or to usual care, and followed for two years. Physical activity is meticulously tracked. By offering patients active involvement, the trial contributes strongly to the concept of personalized medicine.
- Swedish Research Council1 January 2019 - 31 December 2021
- Swedish Research Council1 January 2019 - 31 March 2021
- Dutch Cancer Society1 January 2009 - 1 January 2011
Anställningar
- Anknuten till Forskning, Onkologi-Patologi, Karolinska Institutet, 2024-2027
Examina och utbildning
- Docent, Onkologi, Karolinska Institutet, 2023