Renske Altena
About me
Dr. Renske Altena is a medical oncologist specializing in the treatment of breast and thyroid cancer with a special interest in radiopharmaceutical treatment. She serves as an Associate Professor in Oncology at the Department of Oncology-Pathology at Karolinska Institutet and is a senior consultant and lead physician at Docrates Cancer Center's Clinic in Stockholm, Sweden.
She completed her medical degree at the University of Groningen in the Netherlands in 2006, followed by a Ph.D. in Medical Sciences in 2011. She has held various medical positions in both the Netherlands and Sweden, becoming a consultant oncologist in Sweden in June 2018.
Renske serves various positions of trust, such as the executive board of Cancer Research KI, Cancerklinikens Jubileumfond in Gothenburg and the Ethical Review Authority in Stockholm. She is active in educational activities and outreach for the Swedish Oncological society, SOF.
Research
Dr. Altena's research focuses on clinical trials aimed at improving cancer patient management. A key aspect of her work involves investigating radiopharmaceuticals for cancer visualization and treatment. This is conducted in close collaboration with multidisciplinary experts, including radiopharmacists, nuclear medicine physicians, and medical physicists. Within this team, she leads a work package in a VINNOVA-funded national project, conducting a clinical trial on precision imaging for patients with HER2-low metastatic breast cancer.
Additionally, Dr. Altena is actively involved in several projects exploring the role of physical exercise in cancer treatment and management. Notable examples include the Neo-ACT and EFFECT trials.
Teaching
Over 200 hours teaching to undergraduate and doctoral students
Courses - KI's Introductory Course for Doctoral Supervisors (2022); Grundläggande Högskolpedagogik (2019); Teach the Teacher (2012),
Articles
- Article: EUROPEAN JOURNAL OF RADIOLOGY. 2026;202:112961af Buren S; Romdhani NS; Ulaner G; Yeh R; Tran TA; Axelsson R; Altena R
- Journal article: EJNMMI RESEARCH. 2026;16(1):131Törnblom A; He C; Bolin M; Tzortzakakis A; Fernebro J; Li C; Fridsten S; Altena R; Axelsson R; Siikanen J; Hindorf C
- Journal article: CANCERS. 2026;18(15):2514Mourath D; Romdhani NS; Bergman V; Siikanen J; Tran TA; Alhuseinalkhudhur A; Kistner A; Altena R
- Article: EJNMMI RESEARCH. 2026;16(1):96Bjareback A; Estenberg U; Tzortzakakis A; Axelsson R; Li C; Altena R; Tran TA; Hindorf C
- Article: JOURNAL OF NUCLEAR MEDICINE. 2026;67(5):681-686Nijveldt JJ; Af Burén S; Tran TA; Jussing E; Nilsson JN; Kistner A; Axelsson R; Bergh J; Hartman J; Tzortzakakis A; Altena R
- Article: BREAST CANCER RESEARCH. 2026;28(1):98Zopf EM; Joernaker G; Clauss D; Trevaskis M; Hiensch AE; Schmidt ME; Monninkhof EM; Zimmer P; Belloso J; Heyrman E; Gonzalo RF; Wiskemann J; Mueller J; Bolam KA; Gorecki M; Altena R; Muttiah C; van der Wall E; Aaronson NK; Senkus E; Urruticoechea A; Stuiver MM; Steindorf K; Bloch W; Wengstrom Y; May AM; Rundqvist H
- Article: FRONTIERS IN ONCOLOGY. 2026;16:1812711Altena R; Wiklander OPB; Romdhani NS; Kistner A; Klintman M; Skarping I; Lindman H; Rodriguez VS; Frisell O; Lindgren P; Bratteby K; Jussing E; Feldwisch J; Frejd FY; Cascales HS; Siikanen J; Hindorf C; Tran TA
- Article: SAGE OPEN MEDICAL CASE REPORTS. 2026;14:2050313X261431592Stenman A; Altena R; Falhammar H; Darai-Ramqvist E; Juhlin CC
- Journal article: ANNALS OF ONCOLOGY. 2025;36:s479-S452Altena R; Wiklander OPB; Kistner A; Romdhani NS; Klintman M; Skarping I; Lindman H; Sorensen J; Frisell O; Lindgren P; Bratteby K; Jussing E; Feldwisch J; Frejd FY; Cascales HS; Siikanen J; Hindorf C; Tran T
- Article: INTERNATIONAL JOURNAL OF CANCER. 2025;157(3):490-503Schmidt ME; Hiensch AE; Depenbusch J; Monninkhof EM; Belloso J; Clauss D; Gunasekara N; Trevaskis M; Rundqvist H; Wiskemann J; Mueller J; Sweegers MG; Schneweiss A; Altena R; Kufel-Grabwska J; Bijlsma RM; van Leeuwen-Snoeks L; Huinink DTB; Sonke G; Brandner S; Savas P; Antill Y; White M; Ancizar N; van Der Wall E; Aaronson NK; Senkus E; Urruticoechea A; Zopf EM; Bloch W; Stuiver MM; Wengstroem Y; May AM; Steindorf K
- Article: JOURNAL OF CANCER SURVIVORSHIP. 2025;:1-16Kotte M; Bolam KA; Altena R; Cormie P; Wengstrom Y; Mijwel S
- Article: JOURNAL OF CLINICAL ONCOLOGY. 2025;43(11):1325-1336Schouten AEM; Hiensch AE; Frederix GWJ; Monninkhof EM; Schmidt ME; Clauss D; Gunasekara N; Belloso J; Trevaskis M; Rundqvist H; Wiskemann J; Mueller J; Sweegers MG; Fremd C; Altena R; Bijlsma RM; Sonke G; Lahuerta A; Mann GB; Francis PA; Richardson G; Malter W; Kufel-Grabowska J; van der Wall E; Aaronson NK; Senkus E; Urruticoechea A; Zopf EM; Bloch W; Stuiver MM; Wengstrom Y; Steindorf K; van der Meulen MP; May AM
- Article: WORLD JOURNAL OF SURGERY. 2025;49(4):985-996ten Hoor MBC; Lin JF; Metman MJH; Schaap PMR; Links TP; Altena R; van Ginhoven TM; Zandee WT; Engelsman AF; Kruijff S
- Article: EJNMMI RESEARCH. 2025;15(1):12Bjareback A; Jonmarker O; Tzortzakakis A; Jussing E; Li C; Altena R; Hindorf C; Orlova A; Axelsson R; Tran TA
- Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2025;43(5):513-523Turner N; Saura C; Aftimos P; van den Tweel E; Oesterholt M; Koper N; Colleoni M; Kaczmarek E; Punie K; Song X; Armstrong A; Bianchi G; Stradella A; Ladoire S; Lim JSJ; Quenel-Tueux N; Tan TJ; Escrivá-de-Romaní S; O'Shaughnessy J; TULIP Trial Investigators
- Article: NATURE MEDICINE. 2024;30(10):2957-2966Hiensch AE; Depenbusch J; Schmidt ME; Monninkhof EM; Pelaez M; Clauss D; Gunasekara N; Zimmer P; Belloso J; Trevaskis M; Rundqvist H; Wiskemann J; Mueller J; Sweegers MG; Fremd C; Altena R; Gorecki M; Bijlsma R; van Leeuwen-Snoeks L; ten Bokkel Huinink D; Sonke G; Lahuerta A; Mann GB; Francis PA; Richardson G; Malter W; van der Wall E; Aaronson NK; Senkus E; Urruticoechea A; Zopf EM; Bloch W; Stuiver MM; Wengstrom Y; Steindorf K; May AM
- Journal article: ANNALS OF ONCOLOGY. 2024;35:s402-s403Altena R; Tzortzakakis A; Blomgren A; Jussing E; Ekman S; Tran T; Axelsson R; Bergh J
- Article: EJSO. 2024;50(6):108031Vasileva-Slaveva M; Morales-Espinosa D; Puccini A; Meissner M; Milic M; Lamberti G; Altena R
- Article: JOURNAL OF NUCLEAR MEDICINE. 2024;65(5):700-707Altena R; af Buren S; Blomgren A; Karlsson E; Tzortzakakis A; Brun N; Moein MM; Jussing E; Frejd FY; Bergh J; Tran TA; Hartman J; Axelsson R
- Journal article: CANCER RESEARCH. 2024;84(9):gs02-10-gs02-10May A; Hiensch A; Depenbusch J; Schmidt M; Monninkhof E; Pelaez M; Clauss D; Zimmer P; Belloso J; Trevaskis M; Rundqvist H; Wiskemann J; Muller J; Fremd C; Altena R; Kufel-Grabowska J; Bijlsma R; van Leeuwen-Snoeks L; ten Bokkel-Huinink D; Sonke G; Mann B; Francis P; Richardson G; Alvarez I; Malter W; Van der Wall E; Aaronson N; Senkus E; Urriticoechea A; Zopf E; Bloch W; Stuiver M; Wengstrom Y; Steindorf K
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All other publications
- Letter: JOURNAL OF NUCLEAR MEDICINE. 2025;66(9):1500-1501Skarping I; Tran T; Axelsson R; Altena R
- Letter: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2025;52(9):3073-3074Altena R; Tran TA; Tzortzakakis A
- Book chapter: LEERBOEK ONCOLOGIE. 2025;p. 203-213Koetje JH; Altena R; Kruijff S
- Conference publication: ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. 2024;20:87-88Rundqvist H; Joernaker G; Clauss D; Trevaskis M; Hiensch AE; Schmidt ME; Monninkhof EM; Zimmer P; Belloso J; Heyrman E; Gonzalo RF; Wiskemann J; Mueller J; Altena R; Mann B; Francis P; Richardson G; Antill Y; White M; Savas P; van der wall E; Aaronson NK; Senkus E; Urruticoechea A; Stuiver MM; Steindorf K; Bloch W; Wengstrom Y; May AM; Zopf EM
- Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2024;51:S823-S824Tzortzakakis A; Bjareback A; Hindorf C; Buren SA; Jussing E; Tolmachev V; Varasteh Z; Moein M; Tran T; Axelsson R; Orlova A; Altena R
- Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2024;51:S803Bjareback A; Tzortzakakis A; Estenberg U; Axelsson R; Jonmarker O; Altena R; Li C; Moein M; Orlova A; Tran TA; Hindorf C
- Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2024;51:S670Kistner A; Sadus T; Nilsson J; Altena R; Larsson M; Hindorf C
- Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2024;51:S39-S40Bratteby K; Jussing E; Ferrat M; Bylund L; Tegenbratt T; Garousi J; Frejd F; Furebring T; Frank P; Altena R; Mortensen A; Nestor M; Tran TTA
- Review: BIOMEDICINES. 2024;12(5):1088Eissler N; Altena R; Alhuseinalkhudhur A; Bragina O; Feldwisch J; Wuerth G; Loftenius A; Brun N; Axelsson R; Tolmachev V; Sorensen J; Frejd FY
- Preprint: PREPRINTS.ORG. 2024Eissler N; Altena R; Alhuseinalkhudhur A; Bragina O; Feldwisch J; Wuerth G; Loftenius A; Brun N; Axelsson R; Tolmachev V; Sörensen J; Frejd FY
- Review: LAKARTIDNINGEN. 2024;121:23108Altena R; Nilsson M; Bergman V; Dahlberg J; Juhlin CC; Zedenius J
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2024;47:199Depenbusch J; Hiensch AE; Schmidt M; Monninkhof EM; Puente MP; Clauss D; Zimmer P; Belloso J; Trevaskis M; Rundqvist H; Wiskemann J; Mueller J; Fremd C; Altena R; Kufel-Grabowska J; Bijlsma RM; van Leeuwen-Snoeks L; Ten Bokkel-Huinink D; Sonke G; Mann B; Francis P; Richardson G; Malter W; Lopez IMA; van der Wall E; Aaronson N; Senkus E; Urruticoechea A; Zopf E; Bloch W; Stuiver MM; Wengstrom Y; May A; Steindorf K
- Letter: JOURNAL OF NUCLEAR MEDICINE. 2023;64(11):1841Altena R; af Buren S; Tran T; Axelsson R
- Preprint: RESEARCH SQUARE. 2023Jussing E; Ferrat M; Moein M; Alfredéen H; Tegnebratt T; Bratteby K; Samén E; Feldwisch J; Altena R; Axelsson R; Tran T
- Review: EJNMMI RESEARCH. 2023;13(1):43Altena R; Tzortzakakis A; Buren SA; Tran TA; Frejd FY; Bergh J; Axelsson R
- Study protocol: TRIALS. 2023;24(1):116Kotte M; Bolam KA; Mijwel S; Altena R; Cormie P; Wengstrom Y
- Conference publication: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:S46Bratteby K; Smertinaite L; Omer S; Lu L; Milton S; Jussing E; Siikanen J; Samen E; Axelsson R; Foukakis T; Altena R; Tran T
- Conference publication: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:S99-S100Jussing E; Alfredeen H; Moein MM; Tegnebratt T; Bratteby K; Samen E; Altena R; Axelsson R; Tran T
- Study protocol: PLOS ONE. 2022;17(10):e0274804de Boniface J; Altena R; Ringborg CH; Bolam KA; Wengstrom Y
- Review: CANCERS. 2022;14(19):4665Altena R; Bajalica-Lagercrantz S; Papakonstantinou A
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Grants
- Swedish Research Council1 January 2024 - 31 December 2027Triple negative breast cancer (TNBC) and metastatic urothelial cancer (mUC) have poor prognoses with low survival rates. Treatment options for these metastatic solid tumors have been expanded through the introduction of checkpoint inhibitors (such as atezolizumab and pembrolizumab), systemic chemotherapy, or antibody-drug conjugates (ADC) directed against cell surface proteins like TROP-2 (Trophoblast cell surface antigen 2).A promising approach is to develop radiotheranostics using radiolabelled novel antibodies that target TROP-2 expression, a protein highly expressed in both TNBC and mUC. The concept utilizes a TROP-2 specific monoclonal antibody, radiolabelled with alpha- or beta particle radiation for therapy or radiolabelled with gamma och positron radiation for diagnostics. This approach delivers therapeutic quantities of radioactivity specifically to the tumor cells while sparing normal tissues. The same antibody, radiolabelled with diagnostic radionuclides, tumors are detected by imaging modalities that are currently used in clinical practice. We believe that targeting TROP-2 with radiotheranostics might provide an effective treatment option with a favourable toxicity-benefit balance, and might be a better option for patients who do not respond to ADC or other later line systemic therapies. The project is currently in preclinical development and has high translational feasibility into patients within 4-5 years.
- Swedish Research Council1 December 2021 - 30 November 2025
- Swedish Research Council1 January 2019 - 31 December 2021
- Swedish Research Council1 January 2019 - 31 March 2021
- Dutch Cancer Society1 January 2009 - 1 January 2011
Employments
- Affiliated to Research, Department of Oncology-Pathology, Karolinska Institutet, 2024-2027
Degrees and Education
- Docent, Oncology, Karolinska Institutet, 2023