Ralf Morgenstern

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Utvalda publikationer

Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2009;487(1):42-48
Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione
Alander J; Lengqvist J; Holm PJ; Svensson R; Gerbaux P; van den Heuvel RHH; Hebert H; Griffiths WJ; Armstrong RN; Morgenstern R
Review: PHARMACOLOGICAL REVIEWS. 2007;59(3):207-224
Membrane prostaglandin E synthase-1: A novel therapeutic target
Samuelsson B; Morgenstern R; Jakobsson P-J
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;360(5):934-945
Structural basis for detoxification and oxidative stress protection in membranes
Holm PJ; Bhakat P; Jegerschold C; Gyobu N; Mitsuoka K; Fujiyoshi Y; Morgenstern R; Hebert H

Artiklar

Article: PHARMACOLOGICAL RESEARCH. 2023;196:106899
Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma
Zhang J; Ye Z-W; Chakraborty P; Luo Z; Culpepper J; Aslam M; Zhang L; Johansson K; Haeggstrom JZ; Xu J; Olsson M; Townsend DM; Mehrotra S; Morgenstern R; Tew KD
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2023;299(8):104920
A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression
Zhang J; Ye Z-W; Braeutigam L; Chakraborty P; Luo Z; Culpepper J; Aslam M; Zhang L; Johansson K; Haeggstrom JZ; Xu J; Olsson M; Townsend DM; Mehrotra S; Morgenstern R; Tew KD
Article: FEBS JOURNAL. 2023;290(13):3448-3460
Enzymology of reactive intermediate protection: kinetic analysis and temperature dependence of the mesophilic membrane protein catalyst MGST1
Cebula M; Morgenstern R
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(24):4625-4638
Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone
Larsson K; Steinmetz J; Bergqvist F; Arefin S; Spahiu L; Wannberg J; Pawelzik S-C; Morgenstern R; Stenberg P; Kublickiene K; Korotkova M; Jakobsson P-J
Article: REDOX BIOLOGY. 2018;17:171-179
MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation
Brautigam L; Zhang J; Dreij K; Spahiu L; Holmgren A; Abe H; Tew KD; Townsend DM; Kelner MJ; Morgenstern R; Johansson K
Article: SCIENTIFIC REPORTS. 2017;7(1):7897
Dead-end complex, lipid interactions and catalytic mechanism of microsomal glutathione transferase 1, an electron crystallography and mutagenesis investigation
Kuang Q; Purhonen P; Alander J; Svensson R; Hoogland V; Winerdal J; Spahiu L; Ottosson-Wadlund A; Jegerschold C; Morgenstern R; Hebert H
Article: BRITISH JOURNAL OF NUTRITION. 2017;118(2):154-160
High-dose B-vitamin supplements and risk for age-related cataract: a population-based prospective study of men and women
Selin JZ; Lindblad BE; Bottai M; Morgenstern R; Wolk A
Article: BIOCHEMISTRY. 2017;56(24):3089-3098
Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation
Spahiu L; Alander J; Ottosson-Wadlund A; Svensson R; Lehmer C; Armstrong RN; Morgenstern R
Article: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 2017;1859(2):238-244
Molecular basis for the dual subcellular distribution of microsomal glutathione transferase 1
Shimoji M; Figueroa RA; Neve E; Maksel D; Imreh G; Morgenstern R; Hallberg E
Article: SCIENTIFIC REPORTS. 2016;6:38316
Catalytic Conversion of Lipophilic Substrates by Phase constrained Enzymes in the Aqueous or in the Membrane Phase
Cebula M; Turan IS; Sjodin B; Thulasingam M; Brock J; Chmyrov V; Widengren J; Abe H; Mannervik B; Haeggstrom JZ; Rinaldo-Matthis A; Akkaya EU; Morgenstern R
Article: PLOS ONE. 2016;11(9):e0163600
Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E₂ Synthase 1 and Ser127 Is Not
Raouf J; Rafique N; Goodman MC; Idborg H; Bergqvist F; Armstrong RN; Jakobsson P-J; Morgenstern R; Spahiu L
Article: MOLECULAR PHARMACEUTICS. 2016;13(6):2010-2025
Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells
van Gisbergen MW; Cebula M; Zhang J; Ottosson-Wadlund A; Dubois L; Lambin P; Tew KD; Townsend DM; Haenen GRMM; Drittij-Repders M-J; Saneyoshi H; Araki M; Shishido Y; Ito Y; Arner ESJ; Abe H; Morgenstern R; Johansson K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(4):972-977
A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E₂ synthase
Brock JS; Hamberg M; Balagunaseelan N; Goodman M; Morgenstern R; Strandback E; Samuelsson B; Rinaldo-Matthis A; Haeggstrom JZ
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1854(10):1365-1371
Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity
Ahmad S; Thulasingam M; Palombo I; Daley DO; Johnson KA; Morgenstern R; Haeggstrom JZ; Rinaldo-Matthis A
Journal article: ANALYST. 2014;139(17):4382
Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions (vol 138, pg 7326, 2013)
Shibata A; Nakano Y; Ito M; Araki M; Zhang J; Yoshida Y; Shuto S; Mannervik B; Morgenstern R; Ito Y; Abe H
Article: ANTIOXIDANTS & REDOX SIGNALING. 2014;21(5):700-704
Are Increased Levels of Systemic Oxidative Stress and Inflammation Associated with Age-Related Cataract?
Selin JZ; Lindblad BE; Rautiainen S; Michaelsson K; Morgenstern R; Bottai M; Basu S; Wolk A
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;69:167-171
Absence of MGST1 mRNA and protein expression in human neuroblastoma cell lines and primary tissue
Kelner MJ; Diccianni MB; Yu AL; Rutherford MR; Estes LA; Morgenstern R
Article: JAMA OPHTHALMOLOGY. 2014;132(3):247-252
Total Antioxidant Capacity of the Diet and Risk of Age-Related Cataract A Population-Based Prospective Cohort of Women
Rautiainen S; Lindblad BE; Morgenstern R; Wolk A
Article: FEBS OPEN BIO. 2014;4:886-891
Prenatal expression of thioredoxin reductase 1 (TRXR1) and microsomal glutathione transferase 1 (MGST1) in humans
Bjorkhem-Bergman L; Johansson M; Morgenstern R; Rane A; Ekstrom L
Article: BIOMATERIALS. 2014;35(4):1227-1239
Nanoparticle-directed sub-cellular localization of doxorubicin and the sensitization breast cancer cells by circumventing GST-Mediated drug resistance
Zeng X; Morgenstern R; Nystrom AM
Article: ANALYST. 2013;138(24):7326-7330
Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions
Shibata A; Nakano Y; Ito M; Araki M; Zhang J; Yoshida Y; Shuto S; Mannervik B; Mogenstern R; Ito Y; Abe H
Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2013;177(6):548-555
High-Dose Supplements of Vitamins C and E, Low-Dose Multivitamins, and the Risk of Age-related Cataract: A Population-based Prospective Cohort Study of Men
Selin JZ; Rautiainen S; Lindblad BE; Morgenstern R; Wolk A
Article: BIOCHEMISTRY. 2013;52(10):1755-1764
Catalytic Characterization of Human Microsomal Glutathione S-Transferase 2: Identification of Rate-Limiting Steps
Ahmad S; Niegowski D; Wetterholm A; Haeggstrom JZ; Morgenstern R; Rinaldo-Matthis A
Article: AMERICAN JOURNAL OF MEDICINE. 2012;125(10):974-980
Total Antioxidant Capacity from Diet and Risk of Myocardial Infarction: A Prospective Cohort of Women
Rautiainen S; Levitan EB; Orsini N; Akesson A; Morgenstern R; Mittleman MA; Wolk A
Article: CHEMBIOCHEM. 2012;13(10):1428-1432
Universal Caging Group for the in-Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes
Ito M; Shibata A; Zhang J; Hiroshima M; Sako Y; Nakano Y; Kojima-Aikawa K; Mannervik B; Shuto S; Ito Y; Morgenstern R; Abe H
Article: ACS NANO. 2012;6(3):1925-1938
Microsomal Glutathione Transferase 1 Protects Against Toxicity Induced by Silica Nanoparticles but Not by Zinc Oxide Nanoparticles
Shi J; Karlsson HL; Johansson K; Gogvadze V; Xiao L; Li J; Burks T; Garcia-Bennett A; Uheida A; Muhammed M; Mathur S; Morgenstern R; Kagan VE; Fadeel B
Article: BIOCHEMISTRY. 2012;51(11):2348-2356
Observation of Two Modes of Inhibition of Human Microsomal Prostaglandin E Synthase 1 by the Cyclopentenone 15-Deoxy-Δ^12,14-prostaglandin J₂
Prage EB; Morgenstern R; Jakobsson P-J; Stec DF; Voehler MW; Armstrong RN
Article: BIOCHEMISTRY. 2012;51(4):848-856
Pre-Steady-State Kinetic Characterization of Thiolate Anion Formation in Human Leukotriene C₄ Synthase
Rinaldo-Matthis A; Ahmad S; Wetterholm A; Lachmann P; Morgenstern R; Haeggstrom JZ
Article: MOLECULAR PHARMACEUTICS. 2011;8(5):1698-1708
Characterization of New Potential Anticancer Drugs Designed To Overcome Glutathione Transferase Mediated Resistance
Johansson K; Ito M; Schophuizen CMS; Thengumtharayil SM; Heuser VD; Zhang J; Shimoji M; Vahter M; Wee HA; Dyson PJ; Shibata A; Shuto S; Yoshihiro I; Abe H; Morgenstern R
Article: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES. 2011;9(5):487-495
A Facilitated Approach to Evaluate the Inhibitor Mode and Potency of Compounds Targeting Microsomal Prostaglandin E Synthase-1
Spahiu L; Stenberg P; Larsson C; Wannberg J; Alterman M; Kull B; Nekhotiaeva N; Morgenstern R
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2011;133(35):14109-14119
Synthesis and Characterization of a Series of Highly Fluorogenic Substrates for Glutathione Transferases, a General Strategy
Zhang J; Shibata A; Ito M; Shuto S; Ito Y; Mannervik B; Abe H; Morgenstern R
Article: BIOCHEMISTRY. 2011;50(35):7684-7693
Location of Inhibitor Binding Sites in the Human Inducible Prostaglandin E Synthase, MPGES1
Prage EB; Pawelzik S-C; Busenlehner LS; Kim K; Morgenstern R; Jakobsson P-J; Armstrong RN
Article: PLOS ONE. 2011;6(8):e23128
A Method for Efficient Calculation of Diffusion and Reactions of Lipophilic Compounds in Complex Cell Geometry
Dreij K; Chaudhry QA; Jernstrom B; Morgenstern R; Hanke M
Article: ANTIOXIDANTS & REDOX SIGNALING. 2011;14(1):9-14
Relationship Between Plasma Carotenoids, Fruit and Vegetable Intake, and Plasma Extracellular Superoxide Dismutase Activity in Women: Different in Health and Disease?
Zheng J; Rautiainen S; Morgenstern R; Wolk A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(52):40771-40776
Arginine 104 Is a Key Catalytic Residue in Leukotriene C₄ Synthase
Rinaldo-Matthis A; Wetterholm A; Molina DM; Holm J; Niegowski D; Ohlson E; Nordlund P; Morgenstern R; Haeggstrom JZ
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2010;49(11):1638-1645
Multiple roles of microsomal glutathione transferase 1 in cellular protection A mechanistic study
Johansson K; Jarvliden J; Gogvadze V; Morgenstern R
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2010;92(5):1251-1256
Multivitamin use and the risk of myocardial infarction a population-based cohort of Swedish women
Rautiainen S; Akesson A; Levitan EB; Morgenstern R; Mittleman MA; Wolk A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(38):29254-29261
Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
Pawelzik S-C; Uda NR; Spahiu L; Jegerschold C; Stenberg P; Hebert H; Morgenstern R; Jakobsson P-J
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2010;91(2):487-493
Vitamin C supplements and the risk of age-related cataract: a population-based prospective cohort study in women
Rautiainen S; Lindblad BE; Morgenstern R; Wolk A
Article: CORONARY ARTERY DISEASE. 2009;20(5):322-326
The myeloperoxidase gene and its influence on myocardial infarction in a Swedish population: protective role of the-129A allele in women
Zotova E; Lyrenas L; de Faire U; Morgenstern R; Gigante B; Bennet AM
Article: ANALYTICAL BIOCHEMISTRY. 2009;390(1):52-56
Characterization of a new fluorogenic substrate for microsomal glutathione transferase 1
Alander J; Johansson K; Heuser VD; Farebo H; Jarvliden J; Abe H; Shibata A; Ito M; Ito Y; Morgenstern R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(32):11110-11115
Structural basis for induced formation of the inflammatory mediator prostaglandin E₂
Jegerschold C; Paweizik S-C; Purhonen P; Bhakat P; Gheorghe KR; Gyobu N; Mitsuoka K; Morgenstern R; Jakobsson P-J; Hebert H
Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2008;116(8):1077-1084
Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease
Melen E; Nyberg F; Lindgren CM; Berglind N; Zucchelli M; Nordling E; Hallberg J; Svartengren M; Morgenstern R; Kere J; Bellander T; Wickman M; Pershagen G
Article: BIOCHEMICAL JOURNAL. 2008;413(3):493-504
Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors
Staab CA; Alander J; Brandt M; Lengqvist J; Morgenstern R; Grafstrom RC; Hoog J-O
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2008;87(5):1247-1253
The validity and reproducibility of food-frequency questionnaire-based total antioxidant capacity estimates in Swedish women
Rautiainen S; Serafini M; Morgenstern R; Prior RL; Wolk A
Journal article: SEIBUTSU BUTSURI. 2008;48(supplement):s76
2P-007 Structures of membrane associated proteins in eicosanoid and glutathione metabolism determined by electron crystallography(The 46th Annual Meeting of the Biophysical Society of Japan)
Jegerschold C; Gyobu N; Mitsuoka K; Morgenstern R; Jakobsson P-J; Hevert H
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;355(2):592-596
Protection of cells from oxidative stress by microsomal glutathione transferase 1
Siritantikorn A; Johansson K; Ahlen K; Rinaldi R; Suthiphongchai T; Wilairat P; Morgenstern R
Article: BIOCHEMISTRY. 2007;46(10):2812-2822
Location of substrate binding sites within the integral membrane protein microsomal glutathione transferase-1
Busenlehner LS; Alander J; Jegerscohld C; Holm PJ; Bhakat P; Hebert H; Morgenstern R; Armstrong RN
Article: CARCINOGENESIS. 2007;28(2):465-470
Microsomal glutathione transferase 1 in anticancer drug resistance
Johansson K; Ahlen K; Rinaldi R; Sahlander K; Siritantikorn A; Morgenstern R
Article: ATHEROSCLEROSIS. 2006;187(2):408-414
Association of TNF-α serum levels and TNFA promoter polymorphisms with risk of myocardial infarction
Bennet AM; van Maarle MC; Hallqvist J; Morgenstern R; Frostegard J; Wiman B; Prince JA; de Faire U
Journal article: GBM ANNUAL SPRING MEETING MOSBACH 2006. 2006;2006(Spring)
Mutational Analysis of human glutathione-dependent microsomal Prostaglandin E synthase-1 (mPGES-1)
Pawelzik S-C; Jegerschöld C; Pettersson PL; Morgenstern R; Hebert H; Jakobsson P-J
Journal article: 2006;:146-147
STRUCTURE AND FUNCTION OF MAPEG: LESSONS FROM THE CRYSTAL STRUCTURE OF MICROSOMAL GLUTATHIONE TRANSFERASE 1
Morgenstern R
Journal article: SEIBUTSU BUTSURI. 2006;46(supplement2):s334
2P155 Membrane structure of microsomal glutathione transferase 1 (MGST1) by electron crystallography(34. Membrane protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
Holm PJ; Bhakat P; Jegerschold C; Gyobu N; Mitsuoka K; Fujiyoshi Y; Morgenstern R; Hebert H
Article: FEBS JOURNAL. 2005;272(7):1688-1703
Bioinformatic and enzymatic characterization of the MAPEG superfamily
Bresell A; Weinander R; Lundqvist G; Raza H; Shimoji M; Sun TH; Balk L; Wiklund R; Eriksson J; Jansson C; Persson B; Jakobsson PJ; Morgenstern R
Article: BIOCHEMISTRY. 2004;43(35):11145-11152
Stress sensor triggers conformational response of the integral membrane protein microsomal glutathione transferase 1
Busenlehner LS; Codreanu SG; Holm PJ; Bhakat P; Hebert H; Morgenstern R; Armstrong RN
Article: BIOCHEMISTRY. 2004;43(27):8869-8877
Kinetic characterization of thiolate anion formation and chemical catalysis of activated microsomal glutathione transferase 1
Svensson R; Alander J; Armstrong RN; Morgenstern R
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2004;1678(2-3):163-169
Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain: identification of the promoter region and a comprehensive examination of tissue expression
Kelner MJ; Bagnell RD; Morgenstern R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(14):13311-13316
Observation of an intact noncovalent homotrimer of detergent-solubilized rat microsomal glutathione transferase-1 by electrospray mass spectrometry
Lengqvist J; Svensson R; Evergren E; Morgenstern R; Griffiths WJ
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2004;147(2):163-172
NADPH dependent activation of microsomal glutathione transferase 1
Rinaldi R; Aniya Y; Svensson R; Eliasson E; Swedmark S; Shimoji M; Morgenstern R
Article: BIOCHEMICAL JOURNAL. 2004;378(Pt 2):687-692
Amino acid residue 247 in canine sulphotransferase SULT1D1: a new determinant of substrate selectivity
Tsoi C; Widersten M; Morgenstern R; Swedmark S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(25):22199-22209
Human microsomal prostaglandin E synthase-1 -: Purification, functional characterization, and projection structure determination
Thorén S; Weinander R; Saha S; Jegerschöld C; Pettersson PL; Samuelsson B; Hebert H; Hamberg M; Morgenstern R; Jakobsson PJ
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1627(2-3):79-84
Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3
Ekström L; Lyrenäs L; Jakobsson PJ; Morgenstern R; Kelner MJ
Article: ANALYTICAL BIOCHEMISTRY. 2002;311(2):171-178
Synthesis and characterization of 6-chloroacetyl-2-dimethylaminonaphthalene as a fluorogenic substrate and a mechanistic probe for glutathione transferases
Svensson R; Grenö C; Johansson AS; Mannervik B; Morgenstern R
Article: JOURNAL OF HYPERTENSION. 2002;20(8):1543-1550
Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin-angiotensin-aldosterone system
Iliadou A; Lichtenstein P; Morgenstern R; Forsberg L; Svensson R; de Faire U; Martin NG; Pedersen NL
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2002;401(2):125-133
Canine sulfotransferase SULT1A1: molecular cloning, expression, and characterization
Tsoi C; Morgenstern R; Swedmark S
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2002;1594(2):276-285
The 3-D structure of microsomal glutathione transferase 1 at 6 Å resolution as determined by electron crystallography of p22₁2₁ crystals
Holm PJ; Morgenstern R; Hebert H
Article: TOXICOLOGY. 2001;168(3):251-258
Characterisation of polymeric surfactants that are glutathione transferase mimics
Svensson R; Pamedytyte V; Juodaityte J; Makuska R; Morgenstern R
Article: BIOCHEMICAL JOURNAL. 2001;356(Pt 3):891-897
Identification of a new subfamily of sulphotransferases: cloning and characterization of canine SULT1D1
Tsoi C; Falany CN; Morgenstern R; Swedmark S
Journal article: BIOCHEMICAL JOURNAL. 2001;356(3):891-897
Identification of a new subfamily of sulphotransferases: cloning and characterization of canine SULT1D1
Carrie T; FALANY CN; MORGENSTERN R; SWEDMARK S
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2001;390(1):87-92
Molecular cloning, expression, and characterization of a canine sulfotransferase that is a human ST1B2 ortholog.
Tsoi C; Falany CN; Morgenstern R; Swedmark S
Article: BIOCHEMISTRY. 2001;40(11):3378-3384
Kinetic analysis of the slow ionization of glutathione by microsomal glutathione transferase MGST1
Morgenstern R; Svensson R; Bernat BA; Armstrong RN
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2001;30(5):500-505
A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels
Forsberg L; Lyrenäs L; de Faire U; Morgenstern R
Article: JOURNAL OF INTERNAL MEDICINE. 2001;249(2):127-136
Bioinformatic and experimental tools for identification of single-nucleotide polymorphisms in genes with a potential role for the development of the insulin resistance syndrome
Bennet AM; Näslund TI; Morgenstern R; de Faire U
Article: BIOCHEMISTRY. 2000;39(49):15144-15149
Reactivity of cysteine-49 and its influence on the activation of microsomal glutathione transferase 1: Evidence for subunit interaction
Svensson R; Rinaldi R; Swedmark S; Morgenstern R
Article: EMBO JOURNAL. 2000;19(23):6311-6316
The three-dimensional map of microsomal glutathione transferase 1 at 6 Å resolution
Schmidt-Krey I; Mitsuoka K; Hirai T; Murata K; Cheng Y; Fujiyoshi Y; Morgenstern R; Hebert H
Article: BLOOD CELLS MOLECULES AND DISEASES. 2000;26(5):423-426
Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1
Forsberg L; de Faire U; Marklund SL; Andersson PM; Stegmayr B; Morgenstern R
Journal article: MICROSCOPY AND MICROANALYSIS. 2000;6(S2):232-233
Electron Crystallography of a Small Membrane-Bound Enzyme, Microsomal Glutathione Transferase
Hebert H; Schmidt-Krey I; Mitsuoka K; Hirai T; Murata K; Cheng Y; Fujiyoshi Y; Morgenstern R
Journal article: ATHEROSCLEROSIS. 2000;151(1):97
Using bioinformatics to identify novel SNPs in genes with relevance for insulin resistance
Bennet A; Näslund T; Morgenstern R; de Faire U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(17):13000-13006
Structural organization of the microsomal glutathione S-Transferase gene (MGST1) on chromosome 12p13.1-13.2 -: Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress
Kelner MJ; Bagnell RD; Montoya MA; Estes LA; Forsberg L; Morgenstern R
Article: FEBS LETTERS. 2000;471(1):78-82
Human glutathione dependent prostaglandin E synthase:: gene structure and regulation
Forsberg L; Leeb L; Thorén S; Morgenstern R; Jakobsson PJ
Article: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY. 2000;31(2):107-112
Direct analysis of single-nucleotide polymorphism on double-stranded DNA by pyrosequencing
Nordström T; Ronaghi M; Forsberg L; de Faire U; Morgenstern R; Nyrén P
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 1999;122(2):73-87
Hypophysectomy and/or peroxisome proliferators strongly influence the levels of phase II xenobiotic metabolizing enzymes in rat testis
Mehrotra K; Morgenstern R; Ahlberg MB; Georgellis A
Article: JOURNAL OF INTERNAL MEDICINE. 1999;246(2):211-218
A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development
Boerma M; Forsberg L; Van Zeijl L; Morgenstern R; De Faire U; Lemne C; Erlinge D; Thulin T; Hong Y; Cotgreave IA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(13):7220-7225
Identification of human prostaglandin E synthase:: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
Jakobsson PJ; Thorén S; Morgenstern R; Samuelsson B
Article: JOURNAL OF MOLECULAR BIOLOGY. 1999;288(2):243-253
The projection structure of the membrane protein microsomal glutathione transferase at 3 Å resolution as determined from two-dimensional hexagonal crystals
Schmidt-Krey I; Murata K; Hirai T; Mitsuoka K; Cheng YF; Morgenstern R; Fujiyoshi Y; Hebert H
Article: FEBS JOURNAL. 1999;260(2):409-413
Distribution of microsomal glutathione transferase 1 in mammalian tissues - A predominant alternate first exon in human tissues
Estonius M; Forsberg L; Danielsson O; Weinander R; Kelner MJ; Morgenstern R
Article: PROTEIN SCIENCE. 1999;8(3):689-692
Common structural features of MAPEG -: A widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism
Jakobsson PJ; Morgenstern R; Mancini J; Ford-Hutchinson A; Persson B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(4):1994-1999
Leukotriene C₄ is a tight-binding inhibitor of microsomal glutathione transferase-1 -: Effects of leukotriene pathway modifiers
Bannenberg G; Dahlén SE; Luijerink M; Lundqvist G; Morgenstern R
Article: HUMAN MUTATION. 1999;13(4):294-300
Low yield of polymorphisms from EST blast searching: Analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1
Forsberg L; de Faire U; Morgenstern R
Article: JOURNAL OF STRUCTURAL BIOLOGY. 1998;123(2):87-96
Parameters for the two-dimensional crystallization of the membrane protein microsomal glutathione transferase
Schmidt-Krey I; Lundqvist G; Morgenstern R; Hebert H
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1998;11(6):703-707
A simple alternate substrate test can help determine the aqueous or bilayer location of binding sites for hydrophobic ligands/substrates on membrane proteins
Morgenstern R
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1998;246(2):466-469
A highly active microsomal glutathione transferase from frog (Xenopus laevis) liver that is not activated by N-ethylmaleimide
Sun TH; Ling X; Persson B; Morgenstern R
Article: GENE. 1998;206(1):99-105
The mRNA for GST Pi from FRHK rhesus monkey kidney cells codes for an enzyme with activity towards 1-chloro-2,4-dinitrobenzene in spite of an I68F mutation
Swedmark S; Morgenstern R; Weinander R
Journal article: TECHNICAL TIPS ONLINE. 1998;3(1):88-89
Identification of genetic polymorphisms in the 'expressed sequence tag' (EST) database
Forsberg L; de Faire U; Morgenstern R
Article: JOURNAL OF MOLECULAR BIOLOGY. 1997;271(5):751-758
The 3.0 angstrom projection structure of microsomal glutathione transferase as determined by electron crystallography of p2(1)2(1)2 two-dimensional crystals
Hebert H; SchmidtKrey I; Morgenstern R; Murata K; Hirai T; Mitsuoka K; Fujiyoshi Y
Article: BIOCHEMICAL JOURNAL. 1997;326(Pt 1):193-196
Binding of glutathione and an inhibitor to microsomal glutathione transferase
Sun TH; Morgenstern R
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 1997;104(2-3):131-145
Effects of peroxisome proliferators and/or hypothyroidism on xenobiotic-metabolizing enzymes in rat testis
Mehrotra K; Morgenstern R; Lundqvist G; Becedas L; Ahlberg MB; Georgellis A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(14):8871-8877
Structural and functional aspects of rat microsomal glutathione transferase - The roles of cysteine 49, arginine 107, lysine 67, histidine, and tyrosine residues
Weinander R; Ekstrom L; Andersson C; Raza H; Bergman T; Morgenstern R
Article: BIOCHEMICAL JOURNAL. 1997;323(Pt 1):39-43
Glutathione transferase mimics: Micellar catalysis of an enzymic reaction
Lindkvist B; Weinander R; Engman L; Koetse M; Engberts JBFN; Morgenstern R
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1996;229(2):388-395
Interaction of human leukotriene C-4 synthase and microsomal glutathione transferase in vivo
Surapureddi S; Morgenstern R; Soderstrom M; Hammarstrom S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1996;228(1):165-170
Membrane topology of recombinant rat liver microsomal glutathione transferase expressed in E-coli
Raza H; Weinander R; Ekstrom L; Morgenstern R
Article: BIOCHEMICAL JOURNAL. 1995;311(Pt 3):861-866
HETEROLOGOUS EXPRESSION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE IN SIMIAN COS CELLS AND ESCHERICHIA-COLI
WEINANDER R; MOSIALOU E; DEJONG J; TU CPD; DYPBUKT J; BERGMAN T; BARNES HJ; HOOG JO; MORGENSTERN R
Article: EMBO JOURNAL. 1995;14(16):3864-3869
THE PROJECTION STRUCTURE OF MICROSOMAL GLUTATHIONE TRANSFERASE
HEBERT H; SCHMIDTKREY I; MORGENSTERN R
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1995;320(2):210-216
MICROSOMAL GLUTATHIONE TRANSFERASE - LIPID-DERIVED SUBSTRATES AND LIPID DEPENDENCE
MOSIALOU E; PIEMONTE F; ANDERSSON C; VOS RME; VANBLADEREN PJ; MORGENSTERN R
Article: PROTEIN EXPRESSION AND PURIFICATION. 1995;6(3):352-356
PROTEIN-PROTEIN-INTERACTION AFFINITY-CHROMATOGRAPHY OF LEUKOTRIENE-C-4 SYNTHASE
SODERSTROM M; MORGENSTERN R; HAMMARSTROM S
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1995;1247(2):277-283
KINETIC-STUDIES ON RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE - CONSEQUENCES OF ACTIVATION
ANDERSSON C; PIEMONTE F; MOSIALOU E; WEINANDER R; SUN TH; LUNDQVIST G; ADANG AEP; MORGENSTERN R
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1994;1204(2):298-304
FUNCTIONAL AND STRUCTURAL MEMBRANE TOPOLOGY OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE
ANDERSSON C; WEINANDER R; LUNDQVIST G; DEPIERRE JW; MORGENSTERN R
Journal article: TETRAHEDRON. 1994;50(9):2929-2938
Evidence for a common selenolate intermediate in the glutathione peroxidase-like catalysis of α-(phenylselenenyl) ketones and diphenyl diselenide
Engman L; Andersson C; Morgenstern R; Cotgreave IA; Andersson C-M; Hallberg A
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1994;269(1):71-76
IDENTIFICATION OF N-ACETYLCYSTEINE AS A NEW SUBSTRATE FOR RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE - A STUDY OF THIOL LIGANDS
WEINANDER R; ANDERSON C; MORGENSTERN R
Journal article: ADVANCES IN PHARMACOLOGY. 1994;27:19-35
Enzymology of microsomal glutathione S-transferase.
Andersson C; Mosialou E; Weinander R; Morgenstern R
Journal article: FEBS JOURNAL. 1993;217(2):661-663
AGGREGATION OF PYRENE-LABELED MICROSOMAL GLUTATHIONE-S-TRANSFERASE - EFFECT OF CONCENTRATION
PIEMONTE F; CACCURI AM; MORGENSTERN R; ROSATO N; FEDERICI G
Journal article: BIOCHEMICAL PHARMACOLOGY. 1993;45(8):1645-1651
EVIDENCE THAT RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE IS RESPONSIBLE FOR GLUTATHIONE-DEPENDENT PROTECTION AGAINST LIPID-PEROXIDATION
MOSIALOU E; EKSTROM G; ADANG AEP; MORGENSTERN R
Journal article: FEBS LETTERS. 1993;315(1):77-80
HUMAN LIVER MICROSOMAL GLUTATHIONE TRANSFERASE - SUBSTRATE-SPECIFICITY AND IMPORTANT PROTEIN SITES
MOSIALOU E; ANDERSSON C; LUNDQVIST G; ANDERSSON G; BERGMAN T; JORNVALL H; MORGENSTERN R
Journal article: BASIC LIFE SCIENCES. 1993;61:137-147
Protective role of glutathione, thiols, and analogues in mutagenesis and carcinogenesis.
Jernström B; Morgenstern R; Moldéus P
Journal article: CARCINOGENESIS. 1992;13(10):1719-1723
STUDIES ON GLUTATHIONE TRANSFERASES BELONGING TO CLASS PI IN CELL-LINES WITH DIFFERENT CAPACITIES FOR CONJUGATING (+)-7-BETA,8-ALPHA-DIHYDROXY-9-ALPHA,10-ALPHA-OXY-7,8,9,10-TETRAHYDROBENZO[A]PYRENE
SWEDMARK S; ROMERT L; MORGENSTERN R; JENSSEN D
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1992;84(1):77-84
DETERMINATION OF THE RELATIVE CONTRIBUTIONS OF THE DISELENIDE AND SELENOL FORMS OF EBSELEN IN THE MECHANISM OF ITS GLUTATHIONE PEROXIDASE-LIKE ACTIVITY
MORGENSTERN R; COTGREAVE IA; ENGMAN L
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1992;84(1):69-76
CHARACTERIZATION AND QUANTITATION OF A SELENOL INTERMEDIATE IN THE REACTION OF EBSELEN WITH THIOLS
COTGREAVE IA; MORGENSTERN R; ENGMAN L; AHOKAS J
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1992;1159(1):103-108
THE OLIGOMERIC STRUCTURE OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE STUDIED BY CHEMICAL CROSS-LINKING
LUNDQVIST G; YUCELLINDBERG T; MORGENSTERN R
Journal article: BIOCHEMICAL PHARMACOLOGY. 1992;43(8):1725-1728
MECHANISM OF ACTIVATION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE BY NORADRENALINE AND XANTHINE-OXIDASE
LUNDQVIST G; MORGENSTERN R
Journal article: BIOCHEMICAL PHARMACOLOGY. 1992;43(7):1493-1505
N-ACETYL-PARA-BENZOQUINONE IMINE-INDUCED PROTEIN THIOL MODIFICATION IN ISOLATED RAT HEPATOCYTES
WEIS M; MORGENSTERN R; COTGREAVE IA; NELSON SD; MOLDEUS P
Journal article: BIOCHEMICAL JOURNAL. 1992;282(Pt 1):305-306
NOMENCLATURE FOR HUMAN GLUTATHIONE TRANSFERASES
MANNERVIK B; AWASTHI YC; BOARD PG; HAYES JD; DIILIO C; KETTERER B; LISTOWSKY I; MORGENSTERN R; MURAMATSU M; PEARSON WR; PICKETT CB; SATO K; WIDERSTEN M; WOLF CR
Journal article: BIOCHEMICAL PHARMACOLOGY. 1992;43(2):131-135
STUDIES ON THE ACTIVATION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE IN ISOLATED HEPATOCYTES
LUNDQVIST G; MORGENSTERN R
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1991;266(4):2076-2079
STUDIES ON THE ACTIVITY AND ACTIVATION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE WITH A SERIES OF GLUTATHIONE ANALOGS
ANDERSSON C; MOSIALOU E; ADANG AEP; MULDER GJ; VANDERGEN A; MORGENSTERN R
Journal article: BIOCHEMICAL JOURNAL. 1990;272(2):479-484
CHEMICAL MODIFICATION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE DEFINES RESIDUES OF IMPORTANCE FOR CATALYTIC FUNCTION
ANDERSSON C; MORGENSTERN R
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1990;74(3):275-280
INHIBITION STUDIES ON RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE
MOSIALOU E; MORGENSTERN R
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1990;75(2):185-199
ACTIVATION OF MICROSOMAL GLUTATHIONE TRANSFERASE-ACTIVITY BY REACTIVE INTERMEDIATES FORMED DURING THE METABOLISM OF PHENOL
WALLIN H; MORGENSTERN R
Journal article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1989;275(1):289-294
ACTIVITY OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE TOWARD PRODUCTS OF LIPID-PEROXIDATION AND STUDIES OF THE EFFECT OF INHIBITORS ON GLUTATHIONE-DEPENDENT PROTECTION AGAINST LIPID-PEROXIDATION
MOSIALOU E; MORGENSTERN R
Journal article: BIOCHEMICAL JOURNAL. 1989;260(2):577-582
ACTIVATION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE BY LIMITED PROTEOLYSIS
MORGENSTERN R; LUNDQUIST G; JORNVALL H; DEPIERRE JW
Journal article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 1989;21(10):1169-1175
Ornithine decarboxylase in resting human mononuclear leucocytes: evidence for an endogenous inhibitor.
Johnson DB; Pero RW; Morgenstern R; Joseph PE; Miller DG
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1988;263(17):8430-8436
GENE-EXPRESSION OF RAT AND HUMAN MICROSOMAL GLUTATHIONE S-TRANSFERASES
DEJONG JL; MORGENSTERN R; JORNVALL H; DEPIERRE JW; TU CPD
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1988;263(14):6671-6675
STUDIES ON THE ACTIVITY AND ACTIVATION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE, IN PARTICULAR WITH A SUBSTRATE-ANALOG SERIES
MORGENSTERN R; LUNDQVIST G; HANCOCK V; DEPIERRE JW
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1988;68(1-2):1-11
FEATURES OF MICROSOMAL AND CYTOSOLIC GLUTATHIONE CONJUGATION OF HEXACHLOROBUTADIENE IN RAT-LIVER
WALLIN A; GERDES RG; MORGENSTERN R; JONES TW; ORMSTAD K
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 1987;15(4):719-721
Membrane-bound glutathione transferase.
Morgenstern R; DePierre JW
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1985;260(26):3976-3983
MICROSOMAL GLUTATHIONE TRANSFERASE - PRIMARY STRUCTURE
MORGENSTERN R; DEPIERRE JW; JORNVALL H
Journal article: BIOCHEMICAL PHARMACOLOGY. 1984;33(22):3609-3614
The distribution of microsomal glutathione transferase among different organelles, different organs, and different organisms.
Morgenstern R; Lundqvist G; Andersson G; Balk L; DePierre JW
Journal article: XENOBIOTICA. 1984;14(4):295-301
Induction of cytosolic glutathione transferase and microsomal epoxide hydrolase activities in extrahepatic organs of the rat by phenobarbital, 3-methylcholanthrene and trans-stilbene oxide.
DePierre JW; Seidegård J; Morgenstern R; Balk L; Meijer J; Aström A; Norélius I; Ernster L
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 1984;12(1):58-60
Induction of xenobiotic-metabolizing enzymes by trans-stilbene oxide and 2-acetylaminofluorene: observations on enzyme induction by drugs.
DePierre JW; Seidegård J; Morgenstern R; Balk L; Meijer J; Aström A
Journal article: FEBS LETTERS. 1983;160(1-2):264-268
The amount and nature of glutathione transferases in rat liver microsomes determined by immunochemical methods.
Morgenstern R; Guthenberg C; Mannervik B; DePierre JW
Journal article: FEBS JOURNAL. 1983;134(3):591-597
Microsomal glutathione transferase. Purification in unactivated form and further characterization of the activation process, substrate specificity and amino acid composition.
Morgenstern R; DePierre JW
Journal article: BIOCHEMICAL PHARMACOLOGY. 1983;32(4):721-723
Comparison of the distribution of microsomal and cytosolic glutathione S-transferase activities in different organs of the rat.
DePierre JW; Morgenstern R
Journal article: FEBS JOURNAL. 1982;128(1):243-248
Microsomal glutathione S-transferase. Purification, initial characterization and demonstration that it is not identical to the cytosolic glutathione S-transferases A, B and C.
Morgenstern R; Guthenberg C; Depierre JW
Journal article: CANCER RESEARCH. 1982;42(10):4215-4221
Benzo(a)pyrene metabolism by rat liver microsomes: effects of adding purified glutathione S-transferases A, B, and C.
Morgenstern R; Guthenberg C; Mannervik B; DePierre JW; Ernster L
Journal article: BIOCHEMICAL PHARMACOLOGY. 1982;31(8):1491-1500
Preparation and characterization of subcellular fractions from the liver of the Northern Pike, Esox lucius.
Balk L; Meijer J; Bergstrand A; Aström A; Morgenstern R; Seidegård J; DePierre JW
Journal article: ACTA CHEMICA SCANDINAVICA. 1982;36(4):255-256
A COMPARISON OF INDUCTION OF MICROSOMAL GLUTATHIONE S-TRANSFERASE ACTIVITY IN THE LIVER OF THE MOUSE AND RAT BY DIETARY 2(3)-TERT-BUTYL-4-HYDROXYANISOLE (BHA)
MORGENSTERN R; DOCK L
Journal article: ACTA CHEMICA SCANDINAVICA. 1982;36(4):257-259
PURIFICATION OF MICROSOMAL GLUTATHIONE S-TRANSFERASE
MORGENSTERN R; GUTHENBERG C; DEPIERRE JW
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1981;99(2):682-690
Benzo(alpha)pyrene quinones can be generated by lipid peroxidation and are conjugated with glutathione by glutathione S-transferase b from rat liver.
Morgenstern R; DePierre JW; Lind C; Guthenberg C; Mannervik B; Ernster L
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1981;672(1):65-78
Induction of drug-metabolizing systems and related enzymes with metabolites and structural analogues of stilbene.
Seidegård J; DePierre JW; Morgenstern R; Pilotti A; Ernster L
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1980;631(1):1-10
Induction of glutathione S-transferases A, B and C in rat liver cytosol by trans-stilbene oxide.
Guthenberg C; Morgenstern R; DePierre JW; Mannervik B
Journal article: FEBS JOURNAL. 1980;104(1):167-174
Characterization of rat-liver microsomal glutathione S-transferase activity.
Morgenstern R; Meijer J; Depierre JW; Ernster L
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34(3):229-230
REVERSIBLE ACTIVATION OF RAT-LIVER MICROSOMAL GLUTATHIONE S-TRANSFERASE ACTIVITY BY 5,5'-DITHIOBIS(2-NITROBENZOIC ACID) AND 2,2'-DIPYRIDYL DISULFIDE
MORGENSTERN R; DEPIERRE JW; ERNSTER L
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34(3):224-226
SUBCELLULAR FRACTIONATION OF THE LIVER FROM NORTHERN PIKE, ESOX-LUCIUS
BALK L; MEIJER J; ASTROM A; MORGENSTERN R; SEIDEGARD J; DEPIERRE JW
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34(4):265-273
Chemical studies of tissue polypeptide antigen (TPA). II. Partial amino acid sequences of cyanogen bromide fragments of TPA subunit B1.
Redelius P; Lüning B; Björklund B
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34(3):227-228
Cyclostome carbonic anhydrase. Purification and some properties of the enzyme from erythrocytes of lamprey.
Berglund L; Carlsson U; Kjellström B
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34(3):219-220
Azide reversibly raises cyclic GMP levels in hepatic slices and activates guanylate cyclase.
Danielsson E; Nordström O; Bartfai T
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34(3):216-218
Arrangement of aminophospholipids in the microsomal membranes.
Valtersson C; Lundström H; Dallner G
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34b:119-123
Meisenheimer Complexes from 1,3,5-Trinitrobenzene, tert-Butyl Isocyanide and Copper.
Hansson A-T; Nilsson M; Björklund B; Morgenstern R; Seidegård J; DePierre JW
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34b:53-57
Precise Electrode Potential Measurements by Cyclic Voltammetry and the Application to the Measurement of Heterogeneous Charge Transfer Rates.
Ahlberg E; Svensmark B; Parker VD; Morgenstern R; Seidegård J; DePierre JW
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34b:47-51
Electrophilic Aromatic Substitution by Positive Iodine Species. Iodination of Deactivated Aromatic Compounds.
Lines R; Parker VD; Parker VD; Morgenstern R; Seidegård J; DePierre JW
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34b:1-4
Electrocyclic Rearrangement of a Strained Cyclic beta-Carbonyl Sulfonium Ylide.
Johansen ØH; Groth P; Undheim K; Morgenstern R; Seidegård J; DePierre JW
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 1979;586(1):10-21
Trans-stilbene oxide: A new type of iducer of drug-metabolizing enzymes
Seidegård J; Morgenstern R; DePierre JW; Ernster L
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1979;87(3):657-663
ACTIVATION OF MICROSOMAL GLUTATHIONE S-TRANSFERASE ACTIVITY BY SULFHYDRYL-REAGENTS
MORGENSTERN R; DEPIERRE JW; ERNSTER L
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Book chapter: COMPREHENSIVE TOXICOLOGY. 2026;p. 404-453
4.18 Glutathione Transferases
Mannervik B; Morgenstern R
Review: BIOMOLECULES. 2024;14(6):641
Kinetic Behavior of Glutathione Transferases: Understanding Cellular Protection from Reactive Intermediates
Morgenstern R
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2023;160:107-132
Microsomal glutathione transferase 1 in cancer and the regulation of ferroptosis.
Zhang J; Ye Z-W; Morgenstern R; Townsend DM; Tew KD
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:1099
INHIBITION OF MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES-1) BY GS-248 REDUCES PROSTAGLANDIN E2 BIOSYNTHESIS WHILE INCREASING PROSTACYCLIN IN HUMAN SUBJECTS
Edenius C; Ekstrom G; Kolmert J; Morgenstern R; Stenberg P; Jakobsson PJ; Tornling G
Review: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2020;147:106383
A review on mPGES-1 inhibitors: From preclinical studies to clinical applications
Bergqvist F; Morgenstern R; Jakobsson P-J
Conference publication: CANCER RESEARCH. 2019;79(13):881
A role for microsomal glutathione transferase 1 in melanin biosynthesis in melanoma
Zhang J; Ye Z-W; Townsend DM; Morgenstern R; Tew KD
Conference publication: 2019;:881
Abstract 881: A role for microsomal glutathione transferase 1 in melanin biosynthesis in melanoma
Zhang J; Ye Z-W; Townsend DM; Morgenstern R; Tew KD
Book chapter: GLUTATHIONE. 2018;p. 215-226
The Role of Glutathione in Biosynthetic Pathways and Regulation of the Eicosanoid Metabolism
Morgenstern R; Haeggström JZ; Jakobsson P-J; Flohé L
Book chapter: GLUTATHIONE. 2018;p. 215-226
The Role of Glutathione in Biosynthetic Pathways and Regulation of the Eicosanoid Metabolism
Morgenstern R; Haeggström JZ; Jakobsson P-J; Flohé L
Book chapter: COMPREHENSIVE TOXICOLOGY. 2018;p. 326-362
Glutathione Transferases☆
Armstrong RN; Morgenstern R; Board PG
Published conference paper: JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS. 2014;262:244-260
Surface reactions on the cytoplasmatic membranes-Mathematical modeling of reaction and diffusion systems in a cell
Chaudhry QA; Hanke M; Morgenstern R; Dreij K
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2012;244
Development of new luminogenic probes for detection of glutathione s-transferase activity in living cells
Ito M; Shibata A; Abe H; Zhang J; Morgenstern R; Shuto S; Ito Y
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S60-S61
In silico modeling of the intracellular dynamics of polycyclic aromatic hydrocarbons
Dreij K; Chaudhry QA; Zhang J; Sundberg K; Jernstrom B; Hanke M; Morgenstern R
Review: DRUG METABOLISM REVIEWS. 2011;43(2):300-306
Microsomal glutathione transferase 1: mechanism and functional roles
Morgenstern R; Zhang J; Johansson K
Corrigendum: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2011;93(3):674
Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women (vol 92, pg 1251, 2010)
Rautiainen S; Akesson A; Levitan EB; Morgenstern R; Mittleman MA; Wolk A
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2010;239
New fluorogenic probe for detection of glutathione s-transferase activity in living cells
Ito M; Abe H; Shibata A; Shimizu S; Alander J; Morgenstern R; Ito Y
Conference publication: 2009;:1-5
On the numerical approximation of drug diffusion in complex cell geometry
Chaudhry QA; Hanke M; Morgenstern R
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2009;65:S77
Structure of Microsomal Prostaglandin E Synthase 1 as Determined by Electron Crystallography
Hebert H; Jegerschoeld C; Purhonen P; Bhakat P; Gheorghe K; Gyobu N; Mitsuoka K; Pawelzik S; Jakobsson P-J; Morgenstern R
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;178(1-3):29-35
The Janus face of alcohol dehydrogenase 3
Staab CA; Alander J; Morgenstern R; Grafstrom RC; Hoog J-O
Conference publication: EUROPEAN HEART JOURNAL. 2008;29:353
The-129A allele within myeloperoxidase promoter region exerts a protective role towards myocardial infarction in women
Gigante B; Zotova E; Lyrenas L; De Faire U; Morgenstern R; Bennet A
Book chapter: TOXICOLOGY OF GLUTATHIONE TRANSFERASES. 2006;p. 293-319
Activation of Microsomal Glutathione Transferase 1 in Toxicology
Shimoji M; Aniya Y; Morgenstern R
Book chapter: OXIDATIVE STRESS, DISEASE AND CANCER. 2006;p. 371-460
Oxidative Stress, Genetic Variation, and Disease
Lyrenäs L; Zotova E; Ekström L; Morgenstern R
Conference publication: FREE RADICAL RESEARCH. 2006;40:S65
Microsomal glutathione transferase 1 in anti-cancer drug resistance and oxidative stress
Johansson K; Morgenstern R
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2005;61:C89
Atomic Model of Microsomal Glutathione Transferase 1 from Electron Crystallography
Holm PJ; Bhakat P; Jegerschold C; Gyobu N; Mitsuoka K; Fujiyoshi Y; Morgenstern R; Hebert H
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2005;401:136-146
Microsomal glutathione transferase 1
Morgenstern R
Meeting abstract: JOURNAL OF NUTRITION. 2004;134(11):3173S-3174S
Oxidative stress and human genetic variation
Morgenstern R
Book chapter: REDOX-GENOME INTERACTIONS IN HEALTH AND DISEASE: OXIDATIVE STRESS AND DISEASE. 2003;p.
The Potential Impact of Polymorphism on Oxidative Stress Status
Lyrenäs L; Wincent E; Forsberg L; de Faire U; Morgenstern R
Doctoral thesis: 2003
The kinetic mechanism of microsomal glutathione transferase 1 (MGST1)
Svensson R
Review: DRUG METABOLISM AND DISPOSITION. 2002;30(10):1053-1058
Reactive intermediates and the dynamics of glutathione transferases
Rinaldi R; Eliasson E; Swedmark S; Morgenstern R
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2002;507:287-291
Characterization of microsomal, glutathione dependent prostaglandin E synthase
Jakobsson PJ; Thorén S; Morgenstern R; Samuelsson B
Review: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2001;389(1):84-93
Oxidative stress, human genetic variation, and disease
Forsberg L; de Faire U; Morgenstern R
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):188-191
Reactivity of cysteine-49 in microsomal glutathione transferase 1
Svensson R; Rinaldi R; Swedmark S; Morgenstern R
Published conference paper: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2000;161(2):S20-S24
Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) - A widespread protein superfamily
Jakobsson PJ; Morgenstern R; Mancini J; Ford-Hutchinson A; Persson B
Book chapter: 1999;p. 100-104
Images of a Membrane-bound Detoxification Enzyme at 4Å Resolution Obtained by Electron Cryomicroscopy
Schmidt-Krey I; Hebert H; Morgenstern R
Published conference paper: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY -- PART B: BIOCHEMISTRY AND. 1997;118(4):829-835
Tissue specific expression of glutathione S-transferases, glutathione content and lipid peroxidation in camel tissues
Raza H; Lakhani MS; Ahmed I; John A; Morgenstern R; Montague W
Other: BIOCHEMICAL PHARMACOLOGY. 1995;50(3):421-423
ONTOGENY OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE
LUNDQVIST G; MORGENSTERN R
Published conference paper: ZOOLOGICAL STUDIES. 1995;34:61-63
IMAGES OF A MEMBRANE-BOUND DETOXIFICATION ENZYME AT 4 ANGSTROM RESOLUTION OBTAINED BY ELECTRON CRYOMICROSCOPY
HEBERT H; SCHMIDTKREY I; MORGENSTERN R
Book chapter: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1986;p. 819-823
Induction of unscheduled DNA synthesis in human mononuclear leukocytes by oxidative stress.
Morgenstern R; Pero RW; Miller DG
Book chapter: MICROSOMES, DRUG OXIDATIONS AND CHEMICAL CARCINOGENESIS. 1980;p. 671-674
SUBCELLULAR LOCALIZATION OF GLUTATHIONE S-TRANSFERASE11Supported by NCI Contract No. N01 CP 33363. ACTIVITY IN RAT LIVER
Morgenstern R; Meijer J; DePierre JW; Ernster L
Book chapter: MICROSOMES, DRUG OXIDATIONS AND CHEMICAL CARCINOGENESIS. 1980;p. 1125-1128
DRUG-METABOLIZING SYSTEMS IN THE LIVER OF THE NORTHERN PIKE, ESOX LUCIUS11Supported by a grant from the Swedish Natural Science Research Council.
Balk L; Meijer J; Seidegård J; Morgenstern R; DePierre JW
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Forskningsbidrag

Membrane Protein Enzymology
Swedish Research Council
1 January 2016 - 31 December 2019
Computational Modelling of the Mammalian Cell and Membrane Protein Enzymology
Swedish Research Council
1 January 2012 - 31 December 2014
From detection of single enzyme molecules to tumor treatment
Swedish Foundation for Strategic Research
1 May 2011 - 30 April 2015
Familial factors and cardiovascular disease - genetic-epidemiological studies and molecular mechanisms.
Swedish Research Council
1 January 2011 - 31 December 2013
Computational Modelling of the Mammalian Cell and Membrane Protein Enzymology
Swedish Research Council
1 January 2009 - 31 December 2011

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Professor Emeritus/Emerita, Institutet för miljömedicin, Karolinska Institutet, 2025-2028
Professor, Institutet för miljömedicin, Karolinska Institutet, 2001-2019

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