Ralf Morgenstern

Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Utvalda publikationer

Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2009;487(1):42-48

Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione

Alander J; Lengqvist J; Holm PJ; Svensson R; Gerbaux P; van den Heuvel RHH; Hebert H; Griffiths WJ; Armstrong RN; Morgenstern R
Review: PHARMACOLOGICAL REVIEWS. 2007;59(3):207-224

Membrane prostaglandin E synthase-1: A novel therapeutic target

Samuelsson B; Morgenstern R; Jakobsson P-J
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;360(5):934-945

Structural basis for detoxification and oxidative stress protection in membranes

Holm PJ; Bhakat P; Jegerschold C; Gyobu N; Mitsuoka K; Fujiyoshi Y; Morgenstern R; Hebert H

Artiklar

Journal article: BIOMOLECULES. 2024;14(6):641

Kinetic Behavior of Glutathione Transferases: Understanding Cellular Protection from Reactive Intermediates

Morgenstern R
Article: PHARMACOLOGICAL RESEARCH. 2023;196:106899

Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma

Zhang J; Ye Z-W; Chakraborty P; Luo Z; Culpepper J; Aslam M; Zhang L; Johansson K; Haeggstrom JZ; Xu J; Olsson M; Townsend DM; Mehrotra S; Morgenstern R; Tew KD
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2023;299(8):104920

A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression

Zhang J; Ye Z-W; Braeutigam L; Chakraborty P; Luo Z; Culpepper J; Aslam M; Zhang L; Johansson K; Haeggstrom JZ; Xu J; Olsson M; Townsend DM; Mehrotra S; Morgenstern R; Tew KD
Article: FEBS JOURNAL. 2023;290(13):3448-3460

Enzymology of reactive intermediate protection: kinetic analysis and temperature dependence of the mesophilic membrane protein catalyst MGST1

Cebula M; Morgenstern R
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(24):4625-4638

Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone

Larsson K; Steinmetz J; Bergqvist F; Arefin S; Spahiu L; Wannberg J; Pawelzik S-C; Morgenstern R; Stenberg P; Kublickiene K; Korotkova M; Jakobsson P-J
Article: REDOX BIOLOGY. 2018;17:171-179

MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation

Brautigam L; Zhang J; Dreij K; Spahiu L; Holmgren A; Abe H; Tew KD; Townsend DM; Kelner MJ; Morgenstern R; Johansson K
Article: SCIENTIFIC REPORTS. 2017;7(1):7897

Dead-end complex, lipid interactions and catalytic mechanism of microsomal glutathione transferase 1, an electron crystallography and mutagenesis investigation

Kuang Q; Purhonen P; Alander J; Svensson R; Hoogland V; Winerdal J; Spahiu L; Ottosson-Wadlund A; Jegerschold C; Morgenstern R; Hebert H
Article: BRITISH JOURNAL OF NUTRITION. 2017;118(2):154-160

High-dose B-vitamin supplements and risk for age-related cataract: a population-based prospective study of men and women

Selin JZ; Lindblad BE; Bottai M; Morgenstern R; Wolk A
Article: BIOCHEMISTRY. 2017;56(24):3089-3098

Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation

Spahiu L; Alander J; Ottosson-Wadlund A; Svensson R; Lehmer C; Armstrong RN; Morgenstern R
Article: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 2017;1859(2):238-244

Molecular basis for the dual subcellular distribution of microsomal glutathione transferase 1

Shimoji M; Figueroa RA; Neve E; Maksel D; Imreh G; Morgenstern R; Hallberg E
Article: SCIENTIFIC REPORTS. 2016;6:38316

Catalytic Conversion of Lipophilic Substrates by Phase constrained Enzymes in the Aqueous or in the Membrane Phase

Cebula M; Turan IS; Sjodin B; Thulasingam M; Brock J; Chmyrov V; Widengren J; Abe H; Mannervik B; Haeggstrom JZ; Rinaldo-Matthis A; Akkaya EU; Morgenstern R
Article: MOLECULAR PHARMACEUTICS. 2016;13(6):2010-2025

Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells

van Gisbergen MW; Cebula M; Zhang J; Ottosson-Wadlund A; Dubois L; Lambin P; Tew KD; Townsend DM; Haenen GRMM; Drittij-Repders M-J; Saneyoshi H; Araki M; Shishido Y; Ito Y; Arner ESJ; Abe H; Morgenstern R; Johansson K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(4):972-977

A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E₂ synthase

Brock JS; Hamberg M; Balagunaseelan N; Goodman M; Morgenstern R; Strandback E; Samuelsson B; Rinaldo-Matthis A; Haeggstrom JZ
Article: PLOS ONE. 2016;11(9):e0163600

Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E₂ Synthase 1 and Ser127 Is Not

Raouf J; Rafique N; Goodman MC; Idborg H; Bergqvist F; Armstrong RN; Jakobsson P-J; Morgenstern R; Spahiu L
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1854(10):1365-1371

Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity

Ahmad S; Thulasingam M; Palombo I; Daley DO; Johnson KA; Morgenstern R; Haeggstrom JZ; Rinaldo-Matthis A
Article: ANTIOXIDANTS & REDOX SIGNALING. 2014;21(5):700-704

Are Increased Levels of Systemic Oxidative Stress and Inflammation Associated with Age-Related Cataract?

Selin JZ; Lindblad BE; Rautiainen S; Michaelsson K; Morgenstern R; Bottai M; Basu S; Wolk A
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;69:167-171

Absence of MGST1 mRNA and protein expression in human neuroblastoma cell lines and primary tissue

Kelner MJ; Diccianni MB; Yu AL; Rutherford MR; Estes LA; Morgenstern R
Article: JAMA OPHTHALMOLOGY. 2014;132(3):247-252

Total Antioxidant Capacity of the Diet and Risk of Age-Related Cataract A Population-Based Prospective Cohort of Women

Rautiainen S; Lindblad BE; Morgenstern R; Wolk A
Journal article: ANALYST. 2014;139(17):4382

Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions (vol 138, pg 7326, 2013)

Shibata A; Nakano Y; Ito M; Araki M; Zhang J; Yoshida Y; Shuto S; Mannervik B; Morgenstern R; Ito Y; Abe H
Article: FEBS OPEN BIO. 2014;4:886-891

Prenatal expression of thioredoxin reductase 1 (TRXR1) and microsomal glutathione transferase 1 (MGST1) in humans

Bjorkhem-Bergman L; Johansson M; Morgenstern R; Rane A; Ekstrom L
Article: BIOMATERIALS. 2014;35(4):1227-1239

Nanoparticle-directed sub-cellular localization of doxorubicin and the sensitization breast cancer cells by circumventing GST-Mediated drug resistance

Zeng X; Morgenstern R; Nystrom AM
Article: ANALYST. 2013;138(24):7326-7330

Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions

Shibata A; Nakano Y; Ito M; Araki M; Zhang J; Yoshida Y; Shuto S; Mannervik B; Mogenstern R; Ito Y; Abe H
Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2013;177(6):548-555

High-Dose Supplements of Vitamins C and E, Low-Dose Multivitamins, and the Risk of Age-related Cataract: A Population-based Prospective Cohort Study of Men

Selin JZ; Rautiainen S; Lindblad BE; Morgenstern R; Wolk A
Article: BIOCHEMISTRY. 2013;52(10):1755-1764

Catalytic Characterization of Human Microsomal Glutathione S-Transferase 2: Identification of Rate-Limiting Steps

Ahmad S; Niegowski D; Wetterholm A; Haeggstrom JZ; Morgenstern R; Rinaldo-Matthis A
Article: AMERICAN JOURNAL OF MEDICINE. 2012;125(10):974-980

Total Antioxidant Capacity from Diet and Risk of Myocardial Infarction: A Prospective Cohort of Women

Rautiainen S; Levitan EB; Orsini N; Akesson A; Morgenstern R; Mittleman MA; Wolk A
Article: CHEMBIOCHEM. 2012;13(10):1428-1432

Universal Caging Group for the in-Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes

Ito M; Shibata A; Zhang J; Hiroshima M; Sako Y; Nakano Y; Kojima-Aikawa K; Mannervik B; Shuto S; Ito Y; Morgenstern R; Abe H
Article: ACS NANO. 2012;6(3):1925-1938

Microsomal Glutathione Transferase 1 Protects Against Toxicity Induced by Silica Nanoparticles but Not by Zinc Oxide Nanoparticles

Shi J; Karlsson HL; Johansson K; Gogvadze V; Xiao L; Li J; Burks T; Garcia-Bennett A; Uheida A; Muhammed M; Mathur S; Morgenstern R; Kagan VE; Fadeel B
Article: BIOCHEMISTRY. 2012;51(11):2348-2356

Observation of Two Modes of Inhibition of Human Microsomal Prostaglandin E Synthase 1 by the Cyclopentenone 15-Deoxy-Δ^12,14-prostaglandin J₂

Prage EB; Morgenstern R; Jakobsson P-J; Stec DF; Voehler MW; Armstrong RN
Article: BIOCHEMISTRY. 2012;51(4):848-856

Pre-Steady-State Kinetic Characterization of Thiolate Anion Formation in Human Leukotriene C₄ Synthase

Rinaldo-Matthis A; Ahmad S; Wetterholm A; Lachmann P; Morgenstern R; Haeggstrom JZ
Article: MOLECULAR PHARMACEUTICS. 2011;8(5):1698-1708

Characterization of New Potential Anticancer Drugs Designed To Overcome Glutathione Transferase Mediated Resistance

Johansson K; Ito M; Schophuizen CMS; Thengumtharayil SM; Heuser VD; Zhang J; Shimoji M; Vahter M; Wee HA; Dyson PJ; Shibata A; Shuto S; Yoshihiro I; Abe H; Morgenstern R
Article: ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES. 2011;9(5):487-495

A Facilitated Approach to Evaluate the Inhibitor Mode and Potency of Compounds Targeting Microsomal Prostaglandin E Synthase-1

Spahiu L; Stenberg P; Larsson C; Wannberg J; Alterman M; Kull B; Nekhotiaeva N; Morgenstern R
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2011;133(35):14109-14119

Synthesis and Characterization of a Series of Highly Fluorogenic Substrates for Glutathione Transferases, a General Strategy

Zhang J; Shibata A; Ito M; Shuto S; Ito Y; Mannervik B; Abe H; Morgenstern R
Article: BIOCHEMISTRY. 2011;50(35):7684-7693

Location of Inhibitor Binding Sites in the Human Inducible Prostaglandin E Synthase, MPGES1

Prage EB; Pawelzik S-C; Busenlehner LS; Kim K; Morgenstern R; Jakobsson P-J; Armstrong RN
Article: PLOS ONE. 2011;6(8):e23128

A Method for Efficient Calculation of Diffusion and Reactions of Lipophilic Compounds in Complex Cell Geometry

Dreij K; Chaudhry QA; Jernstrom B; Morgenstern R; Hanke M
Article: ANTIOXIDANTS & REDOX SIGNALING. 2011;14(1):9-14

Relationship Between Plasma Carotenoids, Fruit and Vegetable Intake, and Plasma Extracellular Superoxide Dismutase Activity in Women: Different in Health and Disease?

Zheng J; Rautiainen S; Morgenstern R; Wolk A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(52):40771-40776

Arginine 104 Is a Key Catalytic Residue in Leukotriene C₄ Synthase

Rinaldo-Matthis A; Wetterholm A; Molina DM; Holm J; Niegowski D; Ohlson E; Nordlund P; Morgenstern R; Haeggstrom JZ
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2010;49(11):1638-1645

Multiple roles of microsomal glutathione transferase 1 in cellular protection A mechanistic study

Johansson K; Jarvliden J; Gogvadze V; Morgenstern R
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2010;92(5):1251-1256

Multivitamin use and the risk of myocardial infarction a population-based cohort of Swedish women

Rautiainen S; Akesson A; Levitan EB; Morgenstern R; Mittleman MA; Wolk A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(38):29254-29261

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1

Pawelzik S-C; Uda NR; Spahiu L; Jegerschold C; Stenberg P; Hebert H; Morgenstern R; Jakobsson P-J
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2010;91(2):487-493

Vitamin C supplements and the risk of age-related cataract: a population-based prospective cohort study in women

Rautiainen S; Lindblad BE; Morgenstern R; Wolk A
Article: CORONARY ARTERY DISEASE. 2009;20(5):322-326

The myeloperoxidase gene and its influence on myocardial infarction in a Swedish population: protective role of the-129A allele in women

Zotova E; Lyrenas L; de Faire U; Morgenstern R; Gigante B; Bennet AM
Article: ANALYTICAL BIOCHEMISTRY. 2009;390(1):52-56

Characterization of a new fluorogenic substrate for microsomal glutathione transferase 1

Alander J; Johansson K; Heuser VD; Farebo H; Jarvliden J; Abe H; Shibata A; Ito M; Ito Y; Morgenstern R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(32):11110-11115

Structural basis for induced formation of the inflammatory mediator prostaglandin E₂

Jegerschold C; Paweizik S-C; Purhonen P; Bhakat P; Gheorghe KR; Gyobu N; Mitsuoka K; Morgenstern R; Jakobsson P-J; Hebert H
Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2008;116(8):1077-1084

Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease

Melen E; Nyberg F; Lindgren CM; Berglind N; Zucchelli M; Nordling E; Hallberg J; Svartengren M; Morgenstern R; Kere J; Bellander T; Wickman M; Pershagen G
Article: BIOCHEMICAL JOURNAL. 2008;413(3):493-504

Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors

Staab CA; Alander J; Brandt M; Lengqvist J; Morgenstern R; Grafstrom RC; Hoog J-O
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2008;87(5):1247-1253

The validity and reproducibility of food-frequency questionnaire-based total antioxidant capacity estimates in Swedish women

Rautiainen S; Serafini M; Morgenstern R; Prior RL; Wolk A
Journal article: SEIBUTSU BUTSURI. 2008;48(supplement):s76

2P-007 Structures of membrane associated proteins in eicosanoid and glutathione metabolism determined by electron crystallography(The 46th Annual Meeting of the Biophysical Society of Japan)

Jegerschold C; Gyobu N; Mitsuoka K; Morgenstern R; Jakobsson P-J; Hevert H
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;355(2):592-596

Protection of cells from oxidative stress by microsomal glutathione transferase 1

Siritantikorn A; Johansson K; Ahlen K; Rinaldi R; Suthiphongchai T; Wilairat P; Morgenstern R
Article: BIOCHEMISTRY. 2007;46(10):2812-2822

Location of substrate binding sites within the integral membrane protein microsomal glutathione transferase-1

Busenlehner LS; Alander J; Jegerscohld C; Holm PJ; Bhakat P; Hebert H; Morgenstern R; Armstrong RN
Article: CARCINOGENESIS. 2007;28(2):465-470

Microsomal glutathione transferase 1 in anticancer drug resistance

Johansson K; Ahlen K; Rinaldi R; Sahlander K; Siritantikorn A; Morgenstern R
Journal article: 2006;:146-147

STRUCTURE AND FUNCTION OF MAPEG: LESSONS FROM THE CRYSTAL STRUCTURE OF MICROSOMAL GLUTATHIONE TRANSFERASE 1

Morgenstern R
Article: ATHEROSCLEROSIS. 2006;187(2):408-414

Association of TNF-α serum levels and TNFA promoter polymorphisms with risk of myocardial infarction

Bennet AM; van Maarle MC; Hallqvist J; Morgenstern R; Frostegard J; Wiman B; Prince JA; de Faire U
Journal article: GBM ANNUAL SPRING MEETING MOSBACH 2006. 2006;2006(Spring)

Mutational Analysis of human glutathione-dependent microsomal Prostaglandin E synthase-1 (mPGES-1)

Pawelzik S-C; Jegerschöld C; Pettersson PL; Morgenstern R; Hebert H; Jakobsson P-J
Journal article: SEIBUTSU BUTSURI. 2006;46(supplement2):s334

2P155 Membrane structure of microsomal glutathione transferase 1 (MGST1) by electron crystallography(34. Membrane protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Holm PJ; Bhakat P; Jegerschold C; Gyobu N; Mitsuoka K; Fujiyoshi Y; Morgenstern R; Hebert H
Article: FEBS JOURNAL. 2005;272(7):1688-1703

Bioinformatic and enzymatic characterization of the MAPEG superfamily

Bresell A; Weinander R; Lundqvist G; Raza H; Shimoji M; Sun TH; Balk L; Wiklund R; Eriksson J; Jansson C; Persson B; Jakobsson PJ; Morgenstern R
Article: BIOCHEMISTRY. 2004;43(35):11145-11152

Stress sensor triggers conformational response of the integral membrane protein microsomal glutathione transferase 1

Busenlehner LS; Codreanu SG; Holm PJ; Bhakat P; Hebert H; Morgenstern R; Armstrong RN
Article: BIOCHEMISTRY. 2004;43(27):8869-8877

Kinetic characterization of thiolate anion formation and chemical catalysis of activated microsomal glutathione transferase 1

Svensson R; Alander J; Armstrong RN; Morgenstern R
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2004;1678(2-3):163-169

Structural organization of the murine microsomal glutathione S-transferase gene (MGST1) from the 129/SvJ strain:: identification of the promoter region and a comprehensive examination of tissue expression

Kelner MJ; Bagnell RD; Morgenstern R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(14):13311-13316

Observation of an intact noncovalent homotrimer of detergent-solubilized rat microsomal glutathione transferase-1 by electrospray mass spectrometry

Lengqvist J; Svensson R; Evergren E; Morgenstern R; Griffiths WJ
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2004;147(2):163-172

NADPH dependent activation of microsomal glutathione transferase 1

Rinaldi R; Aniya Y; Svensson R; Eliasson E; Swedmark S; Shimoji M; Morgenstern R
Article: BIOCHEMICAL JOURNAL. 2004;378(Pt 2):687-692

Amino acid residue 247 in canine sulphotransferase SULT1D1: a new determinant of substrate selectivity

Tsoi C; Widersten M; Morgenstern R; Swedmark S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(25):22199-22209

Human microsomal prostaglandin E synthase-1 -: Purification, functional characterization, and projection structure determination

Thorén S; Weinander R; Saha S; Jegerschöld C; Pettersson PL; Samuelsson B; Hebert H; Hamberg M; Morgenstern R; Jakobsson PJ
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1627(2-3):79-84

Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3

Ekström L; Lyrenäs L; Jakobsson PJ; Morgenstern R; Kelner MJ
Article: ANALYTICAL BIOCHEMISTRY. 2002;311(2):171-178

Synthesis and characterization of 6-chloroacetyl-2-dimethylaminonaphthalene as a fluorogenic substrate and a mechanistic probe for glutathione transferases

Svensson R; Grenö C; Johansson AS; Mannervik B; Morgenstern R
Article: JOURNAL OF HYPERTENSION. 2002;20(8):1543-1550

Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin-angiotensin-aldosterone system

Iliadou A; Lichtenstein P; Morgenstern R; Forsberg L; Svensson R; de Faire U; Martin NG; Pedersen NL
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2002;401(2):125-133

Canine sulfotransferase SULT1A1: molecular cloning, expression, and characterization

Tsoi C; Morgenstern R; Swedmark S
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2002;1594(2):276-285

The 3-D structure of microsomal glutathione transferase 1 at 6 Å resolution as determined by electron crystallography of p22₁2₁ crystals

Holm PJ; Morgenstern R; Hebert H
Article: TOXICOLOGY. 2001;168(3):251-258

Characterisation of polymeric surfactants that are glutathione transferase mimics

Svensson R; Pamedytyte V; Juodaityte J; Makuska R; Morgenstern R
Journal article: BIOCHEMICAL JOURNAL. 2001;356(3):891-897

Identification of a new subfamily of sulphotransferases: cloning and characterization of canine SULT1D1

Carrie T; FALANY CN; MORGENSTERN R; SWEDMARK S
Article: BIOCHEMICAL JOURNAL. 2001;356(Pt 3):891-897

Identification of a new subfamily of sulphotransferases: cloning and characterization of canine SULT1D1

Tsoi C; Falany CN; Morgenstern R; Swedmark S
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2001;390(1):87-92

Molecular cloning, expression, and characterization of a canine sulfotransferase that is a human ST1B2 ortholog.

Tsoi C; Falany CN; Morgenstern R; Swedmark S
Article: BIOCHEMISTRY. 2001;40(11):3378-3384

Kinetic analysis of the slow ionization of glutathione by microsomal glutathione transferase MGST1

Morgenstern R; Svensson R; Bernat BA; Armstrong RN
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2001;30(5):500-505

A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels

Forsberg L; Lyrenäs L; de Faire U; Morgenstern R
Article: JOURNAL OF INTERNAL MEDICINE. 2001;249(2):127-136

Bioinformatic and experimental tools for identification of single-nucleotide polymorphisms in genes with a potential role for the development of the insulin resistance syndrome

Bennet AM; Näslund TI; Morgenstern R; de Faire U
Article: BIOCHEMISTRY. 2000;39(49):15144-15149

Reactivity of cysteine-49 and its influence on the activation of microsomal glutathione transferase 1: Evidence for subunit interaction

Svensson R; Rinaldi R; Swedmark S; Morgenstern R
Article: EMBO JOURNAL. 2000;19(23):6311-6316

The three-dimensional map of microsomal glutathione transferase 1 at 6 Å resolution

Schmidt-Krey I; Mitsuoka K; Hirai T; Murata K; Cheng Y; Fujiyoshi Y; Morgenstern R; Hebert H
Article: BLOOD CELLS MOLECULES AND DISEASES. 2000;26(5):423-426

Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1

Forsberg L; de Faire U; Marklund SL; Andersson PM; Stegmayr B; Morgenstern R
Journal article: MICROSCOPY AND MICROANALYSIS. 2000;6(S2):232-233

Electron Crystallography of a Small Membrane-Bound Enzyme, Microsomal Glutathione Transferase

Bailey G; McKernan S; Price R; Walck S; Charest P-M; Gauvin R; Hebert H; Schmidt-Krey I; Mitsuoka K; Hirai T; Murata K; Cheng Y; Fujiyoshi Y; Morgenstern R
Journal article: ATHEROSCLEROSIS. 2000;151(1):97

Using bioinformatics to identify novel SNPs in genes with relevance for insulin resistance

Bennet A; Näslund T; Morgenstern R; de Faire U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(17):13000-13006

Structural organization of the microsomal glutathione S-Transferase gene (MGST1) on chromosome 12p13.1-13.2 -: Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress

Kelner MJ; Bagnell RD; Montoya MA; Estes LA; Forsberg L; Morgenstern R
Article: FEBS LETTERS. 2000;471(1):78-82

Human glutathione dependent prostaglandin E synthase:: gene structure and regulation

Forsberg L; Leeb L; Thorén S; Morgenstern R; Jakobsson PJ
Article: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY. 2000;31(2):107-112

Direct analysis of single-nucleotide polymorphism on double-stranded DNA by pyrosequencing

Nordström T; Ronaghi M; Forsberg L; de Faire U; Morgenstern R; Nyrén P
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 1999;122(2):73-87

Hypophysectomy and/or peroxisome proliferators strongly influence the levels of phase II xenobiotic metabolizing enzymes in rat testis

Mehrotra K; Morgenstern R; Ahlberg MB; Georgellis A
Article: JOURNAL OF INTERNAL MEDICINE. 1999;246(2):211-218

A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development

Boerma M; Forsberg L; Van Zeijl L; Morgenstern R; De Faire U; Lemne C; Erlinge D; Thulin T; Hong Y; Cotgreave IA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(13):7220-7225

Identification of human prostaglandin E synthase:: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

Jakobsson PJ; Thorén S; Morgenstern R; Samuelsson B
Article: JOURNAL OF MOLECULAR BIOLOGY. 1999;288(2):243-253

The projection structure of the membrane protein microsomal glutathione transferase at 3 Å resolution as determined from two-dimensional hexagonal crystals

Schmidt-Krey I; Murata K; Hirai T; Mitsuoka K; Cheng YF; Morgenstern R; Fujiyoshi Y; Hebert H
Article: FEBS JOURNAL. 1999;260(2):409-413

Distribution of microsomal glutathione transferase 1 in mammalian tissues - A predominant alternate first exon in human tissues

Estonius M; Forsberg L; Danielsson O; Weinander R; Kelner MJ; Morgenstern R
Article: PROTEIN SCIENCE. 1999;8(3):689-692

Common structural features of MAPEG -: A widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

Jakobsson PJ; Morgenstern R; Mancini J; Ford-Hutchinson A; Persson B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(4):1994-1999

Leukotriene C₄ is a tight-binding inhibitor of microsomal glutathione transferase-1 -: Effects of leukotriene pathway modifiers

Bannenberg G; Dahlén SE; Luijerink M; Lundqvist G; Morgenstern R
Article: HUMAN MUTATION. 1999;13(4):294-300

Low yield of polymorphisms from EST blast searching: Analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1

Forsberg L; de Faire U; Morgenstern R
Article: JOURNAL OF STRUCTURAL BIOLOGY. 1998;123(2):87-96

Parameters for the two-dimensional crystallization of the membrane protein microsomal glutathione transferase

Schmidt-Krey I; Lundqvist G; Morgenstern R; Hebert H
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1998;11(6):703-707

A simple alternate substrate test can help determine the aqueous or bilayer location of binding sites for hydrophobic ligands/substrates on membrane proteins

Morgenstern R
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1998;246(2):466-469

A highly active microsomal glutathione transferase from frog (Xenopus laevis) liver that is not activated by N-ethylmaleimide

Sun TH; Ling X; Persson B; Morgenstern R
Article: GENE. 1998;206(1):99-105

The mRNA for GST Pi from FRHK rhesus monkey kidney cells codes for an enzyme with activity towards 1-chloro-2,4-dinitrobenzene in spite of an I68F mutation

Swedmark S; Morgenstern R; Weinander R
Journal article: TECHNICAL TIPS ONLINE. 1998;3(1):88-89

Identification of genetic polymorphisms in the 'expressed sequence tag' (EST) database

Forsberg L; de Faire U; Morgenstern R
Article: JOURNAL OF MOLECULAR BIOLOGY. 1997;271(5):751-758

The 3.0 angstrom projection structure of microsomal glutathione transferase as determined by electron crystallography of p2(1)2(1)2 two-dimensional crystals

Hebert H; SchmidtKrey I; Morgenstern R; Murata K; Hirai T; Mitsuoka K; Fujiyoshi Y
Article: BIOCHEMICAL JOURNAL. 1997;326(Pt 1):193-196

Binding of glutathione and an inhibitor to microsomal glutathione transferase

Sun TH; Morgenstern R
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 1997;104(2-3):131-145

Effects of peroxisome proliferators and/or hypothyroidism on xenobiotic-metabolizing enzymes in rat testis

Mehrotra K; Morgenstern R; Lundqvist G; Becedas L; Ahlberg MB; Georgellis A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(14):8871-8877

Structural and functional aspects of rat microsomal glutathione transferase - The roles of cysteine 49, arginine 107, lysine 67, histidine, and tyrosine residues

Weinander R; Ekstrom L; Andersson C; Raza H; Bergman T; Morgenstern R
Article: BIOCHEMICAL JOURNAL. 1997;323(Pt 1):39-43

Glutathione transferase mimics: Micellar catalysis of an enzymic reaction

Lindkvist B; Weinander R; Engman L; Koetse M; Engberts JBFN; Morgenstern R
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1996;229(2):388-395

Interaction of human leukotriene C-4 synthase and microsomal glutathione transferase in vivo

Surapureddi S; Morgenstern R; Soderstrom M; Hammarstrom S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1996;228(1):165-170

Membrane topology of recombinant rat liver microsomal glutathione transferase expressed in E-coli

Raza H; Weinander R; Ekstrom L; Morgenstern R
Article: BIOCHEMICAL JOURNAL. 1995;311(Pt 3):861-866

HETEROLOGOUS EXPRESSION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE IN SIMIAN COS CELLS AND ESCHERICHIA-COLI

WEINANDER R; MOSIALOU E; DEJONG J; TU CPD; DYPBUKT J; BERGMAN T; BARNES HJ; HOOG JO; MORGENSTERN R
Article: EMBO JOURNAL. 1995;14(16):3864-3869

THE PROJECTION STRUCTURE OF MICROSOMAL GLUTATHIONE TRANSFERASE

HEBERT H; SCHMIDTKREY I; MORGENSTERN R
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1995;320(2):210-216

MICROSOMAL GLUTATHIONE TRANSFERASE - LIPID-DERIVED SUBSTRATES AND LIPID DEPENDENCE

MOSIALOU E; PIEMONTE F; ANDERSSON C; VOS RME; VANBLADEREN PJ; MORGENSTERN R
Article: PROTEIN EXPRESSION AND PURIFICATION. 1995;6(3):352-356

PROTEIN-PROTEIN-INTERACTION AFFINITY-CHROMATOGRAPHY OF LEUKOTRIENE-C-4 SYNTHASE

SODERSTROM M; MORGENSTERN R; HAMMARSTROM S
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1995;1247(2):277-283

KINETIC-STUDIES ON RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE - CONSEQUENCES OF ACTIVATION

ANDERSSON C; PIEMONTE F; MOSIALOU E; WEINANDER R; SUN TH; LUNDQVIST G; ADANG AEP; MORGENSTERN R
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1994;1204(2):298-304

FUNCTIONAL AND STRUCTURAL MEMBRANE TOPOLOGY OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE

ANDERSSON C; WEINANDER R; LUNDQVIST G; DEPIERRE JW; MORGENSTERN R
Journal article: TETRAHEDRON. 1994;50(9):2929-2938

Evidence for a common selenolate intermediate in the glutathione peroxidase-like catalysis of α-(phenylselenenyl) ketones and diphenyl diselenide

Engman L; Andersson C; Morgenstern R; Cotgreave IA; Andersson C-M; Hallberg A
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1994;269(1):71-76

IDENTIFICATION OF N-ACETYLCYSTEINE AS A NEW SUBSTRATE FOR RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE - A STUDY OF THIOL LIGANDS

WEINANDER R; ANDERSON C; MORGENSTERN R
Journal article: ADVANCES IN PHARMACOLOGY. 1994;27:19-35

Enzymology of microsomal glutathione S-transferase.

Andersson C; Mosialou E; Weinander R; Morgenstern R
Journal article: FEBS JOURNAL. 1993;217(2):661-663

AGGREGATION OF PYRENE-LABELED MICROSOMAL GLUTATHIONE-S-TRANSFERASE - EFFECT OF CONCENTRATION

PIEMONTE F; CACCURI AM; MORGENSTERN R; ROSATO N; FEDERICI G
Journal article: BIOCHEMICAL PHARMACOLOGY. 1993;45(8):1645-1651

EVIDENCE THAT RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE IS RESPONSIBLE FOR GLUTATHIONE-DEPENDENT PROTECTION AGAINST LIPID-PEROXIDATION

MOSIALOU E; EKSTROM G; ADANG AEP; MORGENSTERN R
Journal article: FEBS LETTERS. 1993;315(1):77-80

HUMAN LIVER MICROSOMAL GLUTATHIONE TRANSFERASE - SUBSTRATE-SPECIFICITY AND IMPORTANT PROTEIN SITES

MOSIALOU E; ANDERSSON C; LUNDQVIST G; ANDERSSON G; BERGMAN T; JORNVALL H; MORGENSTERN R
Journal article: BASIC LIFE SCIENCES. 1993;61:137-147

Protective role of glutathione, thiols, and analogues in mutagenesis and carcinogenesis.

Jernström B; Morgenstern R; Moldéus P
Journal article: CARCINOGENESIS. 1992;13(10):1719-1723

STUDIES ON GLUTATHIONE TRANSFERASES BELONGING TO CLASS PI IN CELL-LINES WITH DIFFERENT CAPACITIES FOR CONJUGATING (+)-7-BETA,8-ALPHA-DIHYDROXY-9-ALPHA,10-ALPHA-OXY-7,8,9,10-TETRAHYDROBENZO[A]PYRENE

SWEDMARK S; ROMERT L; MORGENSTERN R; JENSSEN D
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1992;84(1):77-84

DETERMINATION OF THE RELATIVE CONTRIBUTIONS OF THE DISELENIDE AND SELENOL FORMS OF EBSELEN IN THE MECHANISM OF ITS GLUTATHIONE PEROXIDASE-LIKE ACTIVITY

MORGENSTERN R; COTGREAVE IA; ENGMAN L
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1992;84(1):69-76

CHARACTERIZATION AND QUANTITATION OF A SELENOL INTERMEDIATE IN THE REACTION OF EBSELEN WITH THIOLS

COTGREAVE IA; MORGENSTERN R; ENGMAN L; AHOKAS J
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1992;1159(1):103-108

THE OLIGOMERIC STRUCTURE OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE STUDIED BY CHEMICAL CROSS-LINKING

LUNDQVIST G; YUCELLINDBERG T; MORGENSTERN R
Journal article: BIOCHEMICAL PHARMACOLOGY. 1992;43(8):1725-1728

MECHANISM OF ACTIVATION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE BY NORADRENALINE AND XANTHINE-OXIDASE

LUNDQVIST G; MORGENSTERN R
Journal article: BIOCHEMICAL PHARMACOLOGY. 1992;43(7):1493-1505

N-ACETYL-PARA-BENZOQUINONE IMINE-INDUCED PROTEIN THIOL MODIFICATION IN ISOLATED RAT HEPATOCYTES

WEIS M; MORGENSTERN R; COTGREAVE IA; NELSON SD; MOLDEUS P
Journal article: BIOCHEMICAL JOURNAL. 1992;282(Pt 1):305-306

NOMENCLATURE FOR HUMAN GLUTATHIONE TRANSFERASES

MANNERVIK B; AWASTHI YC; BOARD PG; HAYES JD; DIILIO C; KETTERER B; LISTOWSKY I; MORGENSTERN R; MURAMATSU M; PEARSON WR; PICKETT CB; SATO K; WIDERSTEN M; WOLF CR
Journal article: BIOCHEMICAL PHARMACOLOGY. 1992;43(2):131-135

STUDIES ON THE ACTIVATION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE IN ISOLATED HEPATOCYTES

LUNDQVIST G; MORGENSTERN R
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1991;266(4):2076-2079

STUDIES ON THE ACTIVITY AND ACTIVATION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE WITH A SERIES OF GLUTATHIONE ANALOGS

ANDERSSON C; MOSIALOU E; ADANG AEP; MULDER GJ; VANDERGEN A; MORGENSTERN R
Journal article: BIOCHEMICAL JOURNAL. 1990;272(2):479-484

CHEMICAL MODIFICATION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE DEFINES RESIDUES OF IMPORTANCE FOR CATALYTIC FUNCTION

ANDERSSON C; MORGENSTERN R
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1990;74(3):275-280

INHIBITION STUDIES ON RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE

MOSIALOU E; MORGENSTERN R
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1990;75(2):185-199

ACTIVATION OF MICROSOMAL GLUTATHIONE TRANSFERASE-ACTIVITY BY REACTIVE INTERMEDIATES FORMED DURING THE METABOLISM OF PHENOL

WALLIN H; MORGENSTERN R
Journal article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1989;275(1):289-294

ACTIVITY OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE TOWARD PRODUCTS OF LIPID-PEROXIDATION AND STUDIES OF THE EFFECT OF INHIBITORS ON GLUTATHIONE-DEPENDENT PROTECTION AGAINST LIPID-PEROXIDATION

MOSIALOU E; MORGENSTERN R
Journal article: BIOCHEMICAL JOURNAL. 1989;260(2):577-582

ACTIVATION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE BY LIMITED PROTEOLYSIS

MORGENSTERN R; LUNDQUIST G; JORNVALL H; DEPIERRE JW
Journal article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 1989;21(10):1169-1175

Ornithine decarboxylase in resting human mononuclear leucocytes: evidence for an endogenous inhibitor.

Johnson DB; Pero RW; Morgenstern R; Joseph PE; Miller DG
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1988;263(17):8430-8436

GENE-EXPRESSION OF RAT AND HUMAN MICROSOMAL GLUTATHIONE S-TRANSFERASES

DEJONG JL; MORGENSTERN R; JORNVALL H; DEPIERRE JW; TU CPD
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1988;263(14):6671-6675

STUDIES ON THE ACTIVITY AND ACTIVATION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE, IN PARTICULAR WITH A SUBSTRATE-ANALOG SERIES

MORGENSTERN R; LUNDQVIST G; HANCOCK V; DEPIERRE JW
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1988;68(1-2):1-11

FEATURES OF MICROSOMAL AND CYTOSOLIC GLUTATHIONE CONJUGATION OF HEXACHLOROBUTADIENE IN RAT-LIVER

WALLIN A; GERDES RG; MORGENSTERN R; JONES TW; ORMSTAD K
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 1987;15(4):719-721

Membrane-bound glutathione transferase.

Morgenstern R; DePierre JW
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1985;260(26):3976-3983

MICROSOMAL GLUTATHIONE TRANSFERASE - PRIMARY STRUCTURE

MORGENSTERN R; DEPIERRE JW; JORNVALL H
Journal article: BIOCHEMICAL PHARMACOLOGY. 1984;33(22):3609-3614

The distribution of microsomal glutathione transferase among different organelles, different organs, and different organisms.

Morgenstern R; Lundqvist G; Andersson G; Balk L; DePierre JW
Journal article: XENOBIOTICA. 1984;14(4):295-301

Induction of cytosolic glutathione transferase and microsomal epoxide hydrolase activities in extrahepatic organs of the rat by phenobarbital, 3-methylcholanthrene and trans-stilbene oxide.

DePierre JW; Seidegård J; Morgenstern R; Balk L; Meijer J; Aström A; Norélius I; Ernster L
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 1984;12(1):58-60

Induction of xenobiotic-metabolizing enzymes by trans-stilbene oxide and 2-acetylaminofluorene: observations on enzyme induction by drugs.

DePierre JW; Seidegård J; Morgenstern R; Balk L; Meijer J; Aström A
Journal article: FEBS LETTERS. 1983;160(1-2):264-268

The amount and nature of glutathione transferases in rat liver microsomes determined by immunochemical methods.

Morgenstern R; Guthenberg C; Mannervik B; DePierre JW
Journal article: FEBS JOURNAL. 1983;134(3):591-597

Microsomal glutathione transferase. Purification in unactivated form and further characterization of the activation process, substrate specificity and amino acid composition.

Morgenstern R; DePierre JW
Journal article: BIOCHEMICAL PHARMACOLOGY. 1983;32(4):721-723

Comparison of the distribution of microsomal and cytosolic glutathione S-transferase activities in different organs of the rat.

DePierre JW; Morgenstern R
Journal article: FEBS JOURNAL. 1982;128(1):243-248

Microsomal glutathione S-transferase. Purification, initial characterization and demonstration that it is not identical to the cytosolic glutathione S-transferases A, B and C.

Morgenstern R; Guthenberg C; Depierre JW
Journal article: CANCER RESEARCH. 1982;42(10):4215-4221

Benzo(a)pyrene metabolism by rat liver microsomes: effects of adding purified glutathione S-transferases A, B, and C.

Morgenstern R; Guthenberg C; Mannervik B; DePierre JW; Ernster L
Journal article: BIOCHEMICAL PHARMACOLOGY. 1982;31(8):1491-1500

Preparation and characterization of subcellular fractions from the liver of the Northern Pike, Esox lucius.

Balk L; Meijer J; Bergstrand A; Aström A; Morgenstern R; Seidegård J; DePierre JW
Journal article: ACTA CHEMICA SCANDINAVICA. 1982;36(4):255-256

A COMPARISON OF INDUCTION OF MICROSOMAL GLUTATHIONE S-TRANSFERASE ACTIVITY IN THE LIVER OF THE MOUSE AND RAT BY DIETARY 2(3)-TERT-BUTYL-4-HYDROXYANISOLE (BHA)

MORGENSTERN R; DOCK L
Journal article: ACTA CHEMICA SCANDINAVICA. 1982;36(4):257-259

PURIFICATION OF MICROSOMAL GLUTATHIONE S-TRANSFERASE

MORGENSTERN R; GUTHENBERG C; DEPIERRE JW
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1981;99(2):682-690

Benzo(alpha)pyrene quinones can be generated by lipid peroxidation and are conjugated with glutathione by glutathione S-transferase b from rat liver.

Morgenstern R; DePierre JW; Lind C; Guthenberg C; Mannervik B; Ernster L
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1981;672(1):65-78

Induction of drug-metabolizing systems and related enzymes with metabolites and structural analogues of stilbene.

Seidegård J; DePierre JW; Morgenstern R; Pilotti A; Ernster L
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1980;631(1):1-10

Induction of glutathione S-transferases A, B and C in rat liver cytosol by trans-stilbene oxide.

Guthenberg C; Morgenstern R; DePierre JW; Mannervik B
Journal article: FEBS JOURNAL. 1980;104(1):167-174

Characterization of rat-liver microsomal glutathione S-transferase activity.

Morgenstern R; Meijer J; Depierre JW; Ernster L
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34(4):265-273

Chemical studies of tissue polypeptide antigen (TPA). II. Partial amino acid sequences of cyanogen bromide fragments of TPA subunit B1.

Redelius P; Lüning B; Björklund B
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34(3):227-228

Cyclostome carbonic anhydrase. Purification and some properties of the enzyme from erythrocytes of lamprey.

Berglund L; Carlsson U; Kjellström B
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34(3):219-220

Azide reversibly raises cyclic GMP levels in hepatic slices and activates guanylate cyclase.

Danielsson E; Nordström O; Bartfai T
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34(3):216-218

Arrangement of aminophospholipids in the microsomal membranes.

Valtersson C; Lundström H; Dallner G
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34b:119-123

Meisenheimer Complexes from 1,3,5-Trinitrobenzene, tert-Butyl Isocyanide and Copper.

Hansson A-T; Nilsson M; Björklund B; Morgenstern R; Seidegård J; DePierre JW
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34b:53-57

Precise Electrode Potential Measurements by Cyclic Voltammetry and the Application to the Measurement of Heterogeneous Charge Transfer Rates.

Ahlberg E; Svensmark B; Parker VD; Morgenstern R; Seidegård J; DePierre JW
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34b:47-51

Electrophilic Aromatic Substitution by Positive Iodine Species. Iodination of Deactivated Aromatic Compounds.

Lines R; Parker VD; Parker VD; Morgenstern R; Seidegård J; DePierre JW
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34b:1-4

Electrocyclic Rearrangement of a Strained Cyclic beta-Carbonyl Sulfonium Ylide.

Johansen ØH; Groth P; Undheim K; Morgenstern R; Seidegård J; DePierre JW
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34(3):229-230

REVERSIBLE ACTIVATION OF RAT-LIVER MICROSOMAL GLUTATHIONE S-TRANSFERASE ACTIVITY BY 5,5'-DITHIOBIS(2-NITROBENZOIC ACID) AND 2,2'-DIPYRIDYL DISULFIDE

MORGENSTERN R; DEPIERRE JW; ERNSTER L
Journal article: ACTA CHEMICA SCANDINAVICA. 1980;34(3):224-226

SUBCELLULAR FRACTIONATION OF THE LIVER FROM NORTHERN PIKE, ESOX-LUCIUS

BALK L; MEIJER J; ASTROM A; MORGENSTERN R; SEIDEGARD J; DEPIERRE JW
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 1979;586(1):10-21

Trans-stilbene oxide: A new type of iducer of drug-metabolizing enzymes

Seidegård J; Morgenstern R; DePierre JW; Ernster L
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1979;87(3):657-663

ACTIVATION OF MICROSOMAL GLUTATHIONE S-TRANSFERASE ACTIVITY BY SULFHYDRYL-REAGENTS

MORGENSTERN R; DEPIERRE JW; ERNSTER L
Visa fler

Alla övriga publikationer

Book chapter: REFERENCE MODULE IN BIOMEDICAL SCIENCES. 2024;p.

Glutathione Transferases

Mannervik B; Morgenstern R
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2023;160:107-132

Microsomal glutathione transferase 1 in cancer and the regulation of ferroptosis.

Zhang J; Ye Z-W; Morgenstern R; Townsend DM; Tew KD
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:1099

INHIBITION OF MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES-1) BY GS-248 REDUCES PROSTAGLANDIN E2 BIOSYNTHESIS WHILE INCREASING PROSTACYCLIN IN HUMAN SUBJECTS

Edenius C; Ekstrom G; Kolmert J; Morgenstern R; Stenberg P; Jakobsson PJ; Tornling G
Review: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2020;147:106383

A review on mPGES-1 inhibitors: From preclinical studies to clinical applications

Bergqvist F; Morgenstern R; Jakobsson P-J
Conference publication: CANCER RESEARCH. 2019;79(13):881

A role for microsomal glutathione transferase 1 in melanin biosynthesis in melanoma

Zhang J; Ye Z-W; Townsend DM; Morgenstern R; Tew KD
Conference publication: 2019;:881

Abstract 881: A role for microsomal glutathione transferase 1 in melanin biosynthesis in melanoma

Zhang J; Ye Z-W; Townsend DM; Morgenstern R; Tew KD
Book chapter: GLUTATHIONE. 2018;p. 215-226

The Role of Glutathione in Biosynthetic Pathways and Regulation of the Eicosanoid Metabolism

Morgenstern R; Haeggström JZ; Jakobsson P-J; Flohé L
Book chapter: COMPREHENSIVE TOXICOLOGY. 2018;p. 326-362

Glutathione Transferases☆

Armstrong RN; Morgenstern R; Board PG
Published conference paper: JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS. 2014;262:244-260

Surface reactions on the cytoplasmatic membranes-Mathematical modeling of reaction and diffusion systems in a cell

Chaudhry QA; Hanke M; Morgenstern R; Dreij K
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S60-S61

In silico modeling of the intracellular dynamics of polycyclic aromatic hydrocarbons

Dreij K; Chaudhry QA; Zhang J; Sundberg K; Jernstrom B; Hanke M; Morgenstern R
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2012;244

Development of new luminogenic probes for detection of glutathione s-transferase activity in living cells

Ito M; Shibata A; Abe H; Zhang J; Morgenstern R; Shuto S; Ito Y
Review: DRUG METABOLISM REVIEWS. 2011;43(2):300-306

Microsomal glutathione transferase 1: mechanism and functional roles

Morgenstern R; Zhang J; Johansson K
Corrigendum: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2011;93(3):674

Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women (vol 92, pg 1251, 2010)

Rautiainen S; Akesson A; Levitan EB; Morgenstern R; Mittleman MA; Wolk A
Thesis / dissertation: 2010

Microsomal glutathione transferase 1 in anti-cancer drug resistance and protection against oxidative stress

Johansson, Katarina
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2010;239

New fluorogenic probe for detection of glutathione s-transferase activity in living cells

Ito M; Abe H; Shibata A; Shimizu S; Alander J; Morgenstern R; Ito Y
Conference publication: 2009;:1-5

On the numerical approximation of drug diffusion in complex cell geometry

Chaudhry QA; Hanke M; Morgenstern R
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2009;65:S77

Structure of Microsomal Prostaglandin E Synthase 1 as Determined by Electron Crystallography

Hebert H; Jegerschoeld C; Purhonen P; Bhakat P; Gheorghe K; Gyobu N; Mitsuoka K; Pawelzik S; Jakobsson P-J; Morgenstern R
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;178(1-3):29-35

The Janus face of alcohol dehydrogenase 3

Staab CA; Alander J; Morgenstern R; Grafstrom RC; Hoog J-O
Conference publication: EUROPEAN HEART JOURNAL. 2008;29:353

The-129A allele within myeloperoxidase promoter region exerts a protective role towards myocardial infarction in women

Gigante B; Zotova E; Lyrenas L; De Faire U; Morgenstern R; Bennet A
Book chapter: TOXICOLOGY OF GLUTATHIONE TRANSFERASES. 2006;p. 293-319

Activation of Microsomal Glutathione Transferase 1 in Toxicology

Shimoji M; Aniya Y; Morgenstern R
Book chapter: OXIDATIVE STRESS, DISEASE AND CANCER. 2006;p. 371-460

Oxidative Stress, Genetic Variation, and Disease

Lyrenäs L; Zotova E; Ekström L; Morgenstern R
Conference publication: FREE RADICAL RESEARCH. 2006;40:S65

Microsomal glutathione transferase 1 in anti-cancer drug resistance and oxidative stress

Johansson K; Morgenstern R
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2005;61:C89

Atomic Model of Microsomal Glutathione Transferase 1 from Electron Crystallography

Holm PJ; Bhakat P; Jegerschold C; Gyobu N; Mitsuoka K; Fujiyoshi Y; Morgenstern R; Hebert H
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2005;401:136-146

Microsomal glutathione transferase 1

Morgenstern R
Meeting abstract: JOURNAL OF NUTRITION. 2004;134(11):3173S-3174S

Oxidative stress and human genetic variation

Morgenstern R
Book chapter: REDOX-GENOME INTERACTIONS IN HEALTH AND DISEASE: OXIDATIVE STRESS AND DISEASE. 2003;p.

The Potential Impact of Polymorphism on Oxidative Stress Status

Lyrenäs L; Wincent E; Forsberg L; de Faire U; Morgenstern R
Thesis / dissertation: 2003

The kinetic mechanism of microsomal glutathione transferase 1 (MGST1)

Svensson, Richard
Review: DRUG METABOLISM AND DISPOSITION. 2002;30(10):1053-1058

Reactive intermediates and the dynamics of glutathione transferases

Rinaldi R; Eliasson E; Swedmark S; Morgenstern R
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2002;507:287-291

Characterization of microsomal, glutathione dependent prostaglandin E synthase

Jakobsson PJ; Thorén S; Morgenstern R; Samuelsson B
Review: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2001;389(1):84-93

Oxidative stress, human genetic variation, and disease

Forsberg L; de Faire U; Morgenstern R
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):188-191

Reactivity of cysteine-49 in microsomal glutathione transferase 1

Svensson R; Rinaldi R; Swedmark S; Morgenstern R
Published conference paper: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2000;161(2):S20-S24

Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) - A widespread protein superfamily

Jakobsson PJ; Morgenstern R; Mancini J; Ford-Hutchinson A; Persson B
Book chapter: 1999;p. 100-104

Images of a Membrane-bound Detoxification Enzyme at 4Å Resolution Obtained by Electron Cryomicroscopy

Schmidt-Krey I; Hebert H; Morgenstern R
Published conference paper: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY -- PART B: BIOCHEMISTRY AND. 1997;118(4):829-835

Tissue specific expression of glutathione S-transferases, glutathione content and lipid peroxidation in camel tissues

Raza H; Lakhani MS; Ahmed I; John A; Morgenstern R; Montague W
Other: BIOCHEMICAL PHARMACOLOGY. 1995;50(3):421-423

ONTOGENY OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE

LUNDQVIST G; MORGENSTERN R
Published conference paper: ZOOLOGICAL STUDIES. 1995;34:61-63

IMAGES OF A MEMBRANE-BOUND DETOXIFICATION ENZYME AT 4 ANGSTROM RESOLUTION OBTAINED BY ELECTRON CRYOMICROSCOPY

HEBERT H; SCHMIDTKREY I; MORGENSTERN R
Book chapter: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1986;p. 819-823

Induction of unscheduled DNA synthesis in human mononuclear leukocytes by oxidative stress.

Morgenstern R; Pero RW; Miller DG
Book chapter: MICROSOMES, DRUG OXIDATIONS AND CHEMICAL CARCINOGENESIS. 1980;p. 671-674

SUBCELLULAR LOCALIZATION OF GLUTATHIONE S-TRANSFERASE11Supported by NCI Contract No. N01 CP 33363. ACTIVITY IN RAT LIVER

Morgenstern R; Meijer J; DePierre JW; Ernster L
Book chapter: MICROSOMES, DRUG OXIDATIONS AND CHEMICAL CARCINOGENESIS. 1980;p. 1125-1128

DRUG-METABOLIZING SYSTEMS IN THE LIVER OF THE NORTHERN PIKE, ESOX LUCIUS11Supported by a grant from the Swedish Natural Science Research Council.

Balk L; Meijer J; Seidegård J; Morgenstern R; DePierre JW
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Swedish Research Council

1 January 2016 - 31 December 2019
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Familial factors and cardiovascular disease - genetic-epidemiological studies and molecular mechanisms.

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