Ralf Morgenstern

Ralf Morgenstern

Professor Emeritus/Emerita
Telephone: +46852487131
Visiting address: Nobels väg 13, 17177 Stockholm
Postal address: C6 Institutet för miljömedicin, C6 Biokemisk toxikologi Dreij, 171 77 Stockholm
Part of:

Research

  • tatic drugs and we are investigating inhibitors that could increase treatment efficiency.

    Prostaglandin E (PGE) is very important in pathophysiology related to fever pain and inflammation. In collaboration with Per-Johan Jakobssons group we are investigating a membrane bound enzyme that catalyses the formation of PGE regarding active site location, chemical and kinetic mechanism. Recently the structure of MPGES1 was solved in collaboration with Professor Hans Heberts group at KI which forms the basis for studies on the molecular level. This information is vital to develop new and hopefully safer alternatives to NSAIDs like aspirin. Such development is underway in collaboration with NovaSaid, a company formed together with KI innovations.

    Antioxidant supplements at high levels are increasingly recognised as harmful. The mechanism of the harmful effects have not been elucidated. We have proposed the hypothesis that antioxidants cause a redox dysregulation that lowers endogenous protective enzyme levels. We will investigate this hypothesis initially in cellular systems and later in more complex settings.

    Financing

    The Swedish Cancer Society / Cancerfonden

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