Rachael Sugars
Om mig
Associate Professor
Docent and Lektor / Associate Professor in Oral Biomedicine,Bitrände Prefekt / Deapty Head of Department of Dental Medicine
Avdelningschef / Head of Division for Oral Diagnostics and Surgery at the Department of Dental Medicine
Vice Director for Doctoral Studies
After completing a BSC (Hons) degree in Biomedical Sciences (1997), I undertook my PhD education at Cardiff Dental School (University of Cardiff) sponsored by the Medical Research Council (UK) (2002) . The title was "The influence of recombinant proteoglycans in the mineralisation process" of hard tissues and supervised by Professor Graham Embery and Professor Rachel Waddington. Subsequently, in 2002 I moved to the Karolinska Institutet to join the Centre for Oral Biology for my Post-doc period and continued as senior researcher. In 2009, the Centre for Oral Biology joined with the research unit at the Department of Dental Medicine. Since 2012, I have been a Lecturer at the Department of Dental Medicine, focused on the biomedical education of dental, dental hygienist and continuing professional education dentists. I have been heavily involved in the development of the biomedical dental education and the implementation of the new dental program study plan. Alongside my teaching and mentoring activities, I am also Principal Investigator (see below).
Forskningsbeskrivning
Current research is focused on developing pathological diagnostics and understanding disease processes in the soft tissues of the oral cavity. We
are concerned with the complications that result following hematopoietic cell transplantation in the form of Graft versus Host Disease (GVHD). Oral
manifestations are one of the most common and debilitating complications, and the histopathology poorly understood, particularly associated with
long-standing chronic (c)GVHD. Our ongoing studies are working to understand oral mucosal and salivary gland cGVHD pathogenesis, clinical and diagnostic criteria and the search for predictive biomarkers. The shortage of qualified pathologists and inter-assessor variation is a limitation to diagnostics but digital approaches are providing unique tools to increase capacity, precision and accuracy. Machine learning (ML), and in particular deep learning (DL) algorithms can be trained to perform complex prediction tasks across a multitude of application areas. Using our digital image database we aim to develop a targeted oral digital pathology (DP) platform that will benefit the assessment of cGVHD but other pre-malignant
and malignant oral lesions. Thereby strengthening pathologist / clinician interactions by providing rapid accurate histological assessment for clinical decision-making.
Research group:
Rachael Sugars (PI)
Karin Garming-Legert
Sabrina Svedjevik White (Doctoral Student)
Victor Tollemar
Helena Arvidsson (Affilitated)
Nikolce Tudzarovski
Undervisning
- *Pedagogical profile:*
Biomedical sciences with a focus on the oral cavity in cell and molecular biology, oral biochemistry, craniofacial development, oral histology and
pathology and scientific theory and method.
*Pedagogical expertise:*
Theme Lead for Basic Sciences and Medicine in the Dental Program
Theme Lead for Scientific Development and Thesis Projects in the Dental Program (Year's 1 and 2)
Working Group for the new development of the Dental Program Study Plan (ALVAH) - implemented August 2019
Member of the Program Committee for the Dental Program
Member of the Examination Committee for the Dental Program
Revision of the biomedical education within the Dental Program
*Current teaching activities:*
First-cycle education - Dental Program
Course Leader for Oral Biomedicine 2 (2TL053 - 7.5hp)
Course Leader for Scientific Theory and Method (2TL050 - 3hp)
Supervision of exam thesis projects
Additional teaching responsibilities associated with second- (Master's and
Continuing and Advanced Education) and third-cycle (Doctoral) education.
Artiklar
- Article: ARCHIVES OF ORAL BIOLOGY. 2025;177:106338Ulmner M; Sugars R; Naimi-Akbar A; Lund B
- Journal article: INTERNATIONAL JOURNAL OF DENTISTRY. 2024;2024:2450066Khattar P; Ulmner M; Habel H; Lund B; Sugars RV
- Article: INTERNATIONAL JOURNAL OF DENTISTRY. 2024;2024:2450066Khattar P; Ulmner M; Häbel H; Lund B; Sugars RV
- Article: HELIYON. 2023;9(12):e23051Ulmner M; Sugars R; Naimi-Akbar A; Reseland JE; Lund B
- Article: ORAL DISEASES. 2023;29(8):3346-3359Tollemar V; Strom J; Tudzarovski N; Habel H; Legert KG; Heymann R; Warfvinge G; Le Blanc K; Sugars RV
- Article: HELIYON. 2023;9(4):e15517Tollemar V; Arvidsson H; Habel H; Tudzarovski N; Legert KG; Le Blanc K; Warfvinge G; Sugars RV
- Article: BMC BIOINFORMATICS. 2022;23(1):506Nair A; Arvidsson H; Gatica JEV; Tudzarovski N; Meinke K; Sugars RV
- Article: JOURNAL OF ORAL REHABILITATION. 2022;49(6):599-607Ulmner M; Sugars R; Naimi-Akbar A; Alstergren P; Lund B
- Article: DIAGNOSTICS. 2020;11(1):E46-46Ulmner M; Sugars R; Naimi-Akbar A; Tudzarovski N; Kruger-Weiner C; Lund B
- Article: TRANSPLANTATION AND CELLULAR THERAPY. 2020;26(10):1971-1979Tollemar V; Tudzarovski N; Warfvinge G; Yarom N; Remberger M; Heymann R; Legert KG; Sugars RV
- Article: JOURNAL OF ORAL REHABILITATION. 2020;47(10):1202-1211Ulmner M; Sugars R; Naimi-Akbar A; Suslu S; Reseland JE; Kruger-Weiner C; Lund B
- Article: LARYNGOSCOPE. 2020;130(1):E21-E29Nagubothu SR; Sugars RV; Tudzarovski N; Andren AT; Bottai M; Davies LC; Hertegard S; Le Blanc K
- Article: STEM CELL RESEARCH & THERAPY. 2019;10(1):334Gavin C; Boberg E; Von Bahr L; Bottai M; Andren AT; Wernerson A; Davies LC; Sugars RV; Le Blanc K
- Journal article: JOURNAL OF ORAL PATHOLOGY & MEDICINE. 2019;48(S1):5-83
- Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2018;93A(10):1051-1059Tollemar V; Tudzarovski N; Boberg E; Andren AT; Al-Adili A; Le Blanc K; Legert KG; Bottai M; Warfvinge G; Sugars RV
- Article: ACTA ODONTOLOGICA SCANDINAVICA. 2017;75(7):524-529Vitt A; Slizen V; Bostrom EA; Yucel-Lindberg T; Kats A; Sugars RV; Gustafsson A; Buhlin K
- Article: STEM CELLS TRANSLATIONAL MEDICINE. 2017;6(10):1840-1851Iacobaeus E; Sugars RV; Andren AT; Alm JJ; Qian H; Frantzen J; Newcombe J; Alkass K; Druid H; Bottai M; Roytta M; Le Blanc K
- Journal article: ORAL ONCOLOGY. 2015;51(12):e97-e99Garming-Legert K; Tour G; Sugars R; von Bahr L; Davies LC; Le Blanc K
- Article: ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS. 2015;14:36Vitt A; Sofrata A; Slizen V; Sugars RV; Gustafsson A; Gudkova EI; Kazeko LA; Ramberg P; Buhlin K
- Article: BONE. 2013;53(2):459-467Sugars RV; Olsson M-L; Marchner S; Hultenby K; Wendel M
- Article: CALCIFIED TISSUE INTERNATIONAL. 2012;90(3):219-229Lind T; Hu L; Lind PM; Sugars R; Andersson G; Jacobson A; Melhus H
- Article: PLOS ONE. 2012;7(2):e31525Nikdin H; Olsson M-L; Hultenby K; Sugars RV
- Article: CALCIFIED TISSUE INTERNATIONAL. 2011;88(3):179-188Karlstrom E; Norgard M; Hultenby K; Somogyi-Ganss E; Sugars R; Andersson G; Wendel M
- Article: CALCIFIED TISSUE INTERNATIONAL. 2009;85(1):66-74Baker SM; Sugars RV; Wendel M; Smith AJ; Waddington RJ; Cooper PR; Sloan AJ
- Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1790(2):110-118Karner E; Backesjo C-M; Cedervall J; Sugars RV; Ahrlund-Richter L; Wendel M
- Article: CALCIFIED TISSUE INTERNATIONAL. 2008;82(6):454-464Rehn AP; Cerny R; Sugars RV; Kaukua N; Wendel M
- Article: CELL AND TISSUE RESEARCH. 2007;327(3):511-519Sugars R; Karlstrom E; Christersson C; Olsson M-L; Wendel M; Fried K
- Article: STEM CELLS AND DEVELOPMENT. 2007;16(1):39-52Karner E; Unger C; Sloan AJ; Ahrlund-Richter L; Sugars RV; Wendel M
- Journal article: STEM CELLS AND DEVELOPMENT. 2007;0(0):070118101949001Kärner E; Unger C; Sloan AJ; Ährlund-Richter L; Sugars RV; Wendel M
- Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2006;1763(10):1031-1039Sugars RV; Karner E; Petersson U; Ganss B; Wendel M
- Article: EUROPEAN JOURNAL OF ORAL SCIENCES. 2006;114(3):223-231Milan AM; Sugars RV; Embery G; Waddington RJ
- Article: EUROPEAN JOURNAL OF ORAL SCIENCES. 2006;114(1):89-92Sugars RV; Olsson ML; Waddington R; Wendel M
- Article: CALCIFIED TISSUE INTERNATIONAL. 2005;76(2):127-135Milan AM; Sugars RV; Embery G; Waddington RJ
- Article: CALCIFIED TISSUE INTERNATIONAL. 2004;75(3):197-204Milan AM; Sugars RV; Embery G; Waddington RJ
- Article: STEM CELLS AND DEVELOPMENT. 2004;13(4):421-435Gertow K; Wolbank S; Rozell B; Sugars R; Andäng M; Parish CL; Imreh MP; Wendel M; Ährlund-Richter L
- Article: BONE. 2004;34(6):949-960Petersson U; Somogyi E; Reinholt FP; Karlsson T; Sugars RV; Wendel M
- Article: CALCIFIED TISSUE INTERNATIONAL. 2004;74(4):366-376Somogyi E; Petersson U; Sugars RV; Hultenby K; Wendell M
- Article: PROTEIN EXPRESSION AND PURIFICATION. 2002;25(1):180-188Sugars RV; Waddington RJ; Embery G
- Visa fler
Alla övriga publikationer
- Review: FRONTIERS IN IMMUNOLOGY. 2023;14:1151493Tollemar V; Legert K; Sugars RVV
- Book chapter: INFORMATION PROCESSING IN MEDICAL IMAGING: LECTURE NOTES IN COMPUTER SCIENCE. 2023;p. 265-277Hasegawa T; Arvidsson H; Tudzarovski N; Meinke K; Sugars RV; Ashok Nair A
- Conference publication: BLOOD. 2017;130Boberg E; Von Bahr L; Heldring N; Afram G; Iacobaeus E; Lindstrom C; Garming-Legert K; Ljungman P; Sugars R; Davies L; Kadri N; Le Blanc K
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):285Boberg E; von Bahr L; Heldring N; Afram G; Iacobaeus E; Modin C; Garming-Legert K; Ljungman P; Sugars R; Davies L; Kadri N; Le Blanc K
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2016;22:155Iacobaeus E; Sugars RV; Tornqvist AA; Alm JJ; Alkass K; Druid H; Roytta M; Le Blanc K
- Book chapter: BONE GRAFTING. 2012;p.Rosén A; Sugars R
- Conference publication: FEBS JOURNAL. 2009;276:31Wendel M; Sugars R; Karner E
- Conference publication: JOURNAL OF DENTAL RESEARCH. 2003;82:490Sugars RV; Waddington RJ; Embery G
- Review: EUROPEAN CELLS & MATERIALS. 2003;6:12-21Waddington RJ; Roberts HC; Sugars RV; Schönherr E
- Conference publication: JOURNAL OF DENTAL RESEARCH. 2003;82:B77Petersson U; Somogyi E; Sugars RV; Wendel M
- Conference publication: JOURNAL OF DENTAL RESEARCH. 2003;82:B76Milan AM; Sugars RV; Waddington R; Embery G
- Conference publication: JOURNAL OF DENTAL RESEARCH. 2003;82:B46Baker SM; Sloan AJ; Sugars RV; Williams DW; Waddington R; Smith AJ
- Published conference paper: CONNECTIVE TISSUE RESEARCH. 2003;44:189-195Sugars RV; Milan AA; Brown JO; Waddington RJ; Hall RC; Embery G
- Conference publication: JOURNAL OF DENTAL RESEARCH. 2002;81:A439Sugars RV; Waddington RJ; Embery G
- Conference publication: JOURNAL OF DENTAL RESEARCH. 2001;80(4):1181Sugars RV; Milan AM; Hall RC; Waddington RJ; Embery G
- Conference publication: JOURNAL OF DENTAL RESEARCH. 2000;79(5):1176Sugars RV
- Conference publication: JOURNAL OF DENTAL RESEARCH. 1999;78(5):1054Sugars RV; Waddington RJ; Embery G
Forskningsbidrag
- Oral Complications Post-Hematopoietic Cell Transplantationto Model the Transition of Oral Potentially Malignant Disorders to Invasive Oral CancerCancerfonden1 January 2025 - 31 December 2027
- Cathrine Everts Forskningsstiftelse1 August 2024 - 31 July 2025
- Clinical and diagnostic personalized management of patients with oral complications post-hematopoietic stem cell transplantationStyrgruppen KI/Region Stockholm för odontologisk forskning (SOF)1 January 2024 - 31 December 2026
- Clinical and artificial intelligence-prediction models for oral mucosal lesion diagnosticsALF medicin1 October 2020 - 31 December 2023
- Developing Histopathology Models for Oral Lesion Diagnostics Using Artificial IntelligenceStyrgruppen KI/Region Stockholm för odontologisk forskning (SOF)1 January 2020 - 31 December 2022
- Oral Graft-Versus-Host Disease: Clinical and Pathological Staging, and Identification of Diagnostic and Prognostic BiomarkersStyrgruppen KI/Region Stockholm för odontologisk forskning (SOF)1 January 2016 - 31 December 2018
- Swedish Research Council1 January 2010 - 31 December 2012
Anställningar
- Lektor, Odontologi, Karolinska Institutet, 2020-
Examina och utbildning
- Docent, Cellbiologi, Karolinska Institutet, 2011