Peter Århem

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: SCIENTIFIC REPORTS. 2019;9(1):8175

Closed and open state dependent block of potassium channels cause opposing effects on excitability - a computational approach

Agren R; Nilsson J; Arhem P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2018;21(12):1102-1108

The Beta-Arrestin-Biased Dopamine D₂ Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation

Agren R; Arhem P; Nilsson J; Sahlholm K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;496(1):101-104

Point mutation of a conserved aspartate, D69, in the muscarinic M₂ receptor does not modify voltage-sensitive agonist potency

Agren R; Sahlholm K; Nilsson J; Arhem P
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2018;12:33

The Importance of the Dissociation Rate in Ion Channel Blocking

Zeberg H; Nilsson J; Arhem P
Article: BIOPHYSICAL JOURNAL. 2016;111(8):1679-1691

Extracellular Linkers Completely Transplant the Voltage Dependence from Kv1.2 Ion Channels to Kv2.1

Elinder F; Madeja M; Zeberg H; Arhem P
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2016;26(3):467-476

The fast-off hypothesis revisited: A functional kinetic study of antipsychotic antagonism of the dopamine D₂ receptor

Sahlholm K; Zeberg H; Nilsson J; Ogren SO; Fuxe K; Arhem P
Article: MOLECULAR PAIN. 2015;11:44

G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy

Lyu C; Mulder J; Barde S; Sahlholm K; Zeberg H; Nilsson J; Arhem P; Hokfelt T; Fried K; Shi T-JS
Article: JOURNAL OF NEUROPHYSIOLOGY. 2015;113(2):537-549

Density of voltage-gated potassium channels is a bifurcation parameter in pyramidal neurons

Zeberg H; Robinson HPC; Arhem P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;17(1):149-155

Typical and atypical antipsychotics do not differ markedly in their reversibility of antagonism of the dopamine D₂ receptor

Sahlholm K; Marcellino D; Nilsson J; Ogren SO; Fuxe K; Arhem P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(2):690-695

Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db^-/db^- mouse, a type 2 diabetes model

Shi T-JS; Zhang M-D; Zeberg H; Nilsson J; Grunler J; Liu S-X; Xiang Q; Persson J; Fried KJ; Catrina SB; Watanabe M; Arhem P; Brismar K; Hokfelt TGM
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2012;1818(12):3081-3089

Voltage sensitivities and deactivation kinetics of histamine H₃ and H₄ receptors

Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: NEUROPHARMACOLOGY. 2011;61(5-6):937-949

Agonist-specific voltage sensitivity at the dopamine D_2S receptor - Molecular determinants and relevance to therapeutic ligands

Sahlholm K; Barchad-Avitzur O; Marcellino D; Gomez-Soler M; Fuxe K; Ciruela F; Arhem P
Article: JOURNAL OF NEUROPHYSIOLOGY. 2010;103(5):2900-2911

Spontaneous Ryanodine-Receptor-Dependent Ca²⁺-Activated K⁺ Currents and Hyperpolarizations in Rat Medial Preoptic Neurons

Klement G; Druzin M; Haage D; Malinina E; Arhem P; Johansson S
Article: PLOS COMPUTATIONAL BIOLOGY. 2010;6(4):e1000753

Ion Channel Density Regulates Switches between Regular and Fast Spiking in Soma but Not in Axons

Zeberg H; Blomberg C; Arhem P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;394(4):988-992

Cocaine produces D₂R-mediated conformational changes in the adenosine A_2AR-dopamine D₂R heteromer

Marcellino D; Navarro G; Sahlholm K; Nilsson J; Agnati LF; Canela EI; Lluis C; Arhem P; Franco R; Fuxe K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;377(4):1216-1221

Voltage-sensitivity at the human dopamine D_2S receptor is agonist-specific

Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Article: BIOPHYSICAL JOURNAL. 2008;95(11):5138-5152

Bupivacaine Blocks N-Type Inactivating K_v Channels in the Open State: No Allosteric Effect on Inactivation Kinetics

Nilsson J; Madeja M; Elinder F; Arhem P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;374(3):496-501

Differential voltage-sensitivity of D₂-like dopamine receptors

Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;591(1-3):52-58

Electrophysiology-based analysis of human histamine H₄ receptor pharmacology using GIRK channel coupling in Xenopus oocytes

Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: SYNAPSE. 2008;62(6):476-480

Voltage-dependence of the human dopamine D₂ receptor

Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: BIOPHYSICAL JOURNAL. 2008;94(8):3014-3022

A tyrosine substitution in the cavity wall of a K channel induces an inverted inactivation

Klement G; Nilsson J; Arhem P; Elinder F
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):1-7

On the opening of voltage-gated ion channels

Elinder F; Nilsson J; Arhem P
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2007;567(3):206-210

The human histamine H₃ receptor couples to GIRK channels in Xenopus oocytes

Sahlhollm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: DIABETOLOGIA. 2007;50(8):1670-1677

Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters:: indications for a long-chain acyl-CoA ester binding motif

Braenstroem R; Leibiger IB; Leibiger B; Klement G; Nilsson J; Arhem P; Aspinwall CA; Corkey BE; Larsson O; Berggren R-O
Article: BIOPHYSICAL JOURNAL. 2006;90(12):4392-4404

Channel density regulation of firing patterns in a cortical neuron model

Arhem P; Klement G; Blomberg C
Article: BMC NEUROSCIENCE. 2005;6:65

A truncated Kv1.1 protein in the brain of the megencephaly mouse:: expression and interaction -: art. no. 65

Persson AS; Klement G; Almgren M; Sahlholm K; Nilsson J; Petersson S; Århem P; Schalling M; Lavebratt C
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2003;18(12):3231-3240

Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly

Petersson S; Persson AS; Johansen JE; Ingvar M; Nilsson J; Klement G; Århem P; Schalling M; Lavebratt C
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1652(1):35-51

Computational modelling of the open-state K_v1.5 ion channel block by bupivacaine

Luzhkov VB; Nilsson J; Århem P; Åqvist J
Article: MOLECULAR PHARMACOLOGY. 2003;63(6):1417-1429

Local anesthetic block of Kv channels:: Role of the S6 helix and the S5-S6 linker for bupivacaine action

Nilsson J; Madeja M; Århem P
Article: BIOPHYSICAL JOURNAL. 2001;80(4):1802-1809

Localization of the extracellular end of the voltage sensor S4 in a potassium channel

Elinder F; Århem P; Larsson HP
Article: LIFE SCIENCES. 2001;68(16):1817-1826

NMDA and glycine regulate the affinity of the Mg²⁺-block site in NR1-1a/NR2A NMDA receptor channels expressed in Xenopus oocytes

Liu Y; Hill RH; Århem P; von Euler G
Article: LAKARTIDNINGEN. 2000;97(30-31):3388-3390

[The Lasker Prize 1999. Molecular structure of ion channels as a theme of awarded research].

Arhem P
Article: BIOPHYSICAL JOURNAL. 1999;77(3):1358-1362

Role of individual surface charges of voltage-gated K channels

Elinder F; Århem P
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1998;360(1):21-29

Mechanisms of bupivacaine action on Na⁺ and K⁺ channels in myelinated axons of Xenopus laevis

Nilsson J; Elinder F; Århem P
Article: JOURNAL OF MEMBRANE BIOLOGY. 1998;165(2):183-189

Divalent cation effects on the shaker K channel suggest a pentapeptide sequence as determinant of functional surface charge density

Elinder F; Liu Y; Århem P
Article: JOURNAL OF MEMBRANE BIOLOGY. 1998;165(2):175-181

The functional surface charge density of a fast K channel in the myelinated axon of Xenopus laevis

Elinder F; Århem P
Article: JOURNAL OF THEORETICAL BIOLOGY. 1997;187(4):601-612

On the coevolution of cognition and consciousness

Arhem P; Liljenstrom H
Article: BIOPHYSICAL JOURNAL. 1997;73(1):179-185

Tail currents in the myelinated axon of Xenopus laevis suggest a two-open-state Na channel

Elinder F; Arhem P
Article: JOURNAL OF GENERAL PHYSIOLOGY. 1996;108(4):325-332

Surface charges of K channels - Effects of strontium on five cloned channels expressed in Xenopus oocytes

Elinder F; Madeja M; Arhem P
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Letter: MOLECULAR PSYCHIATRY. 2013;18(1):12-14

The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the σ-1 receptor

Sahlholm K; Arhem P; Fuxe K; Marcellino D
Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):126A

Local Anesthetics on Kv Channels - Closed State Binding of Bupivacaine?

Nilsson J; Zeberg H; Madeja M; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):26A

Novel Aspects of the Reversibility of the Antagonism at the Dopamine D2 Receptor by Antipsychotics

Sahlholm K; Frisk S; Nilsson J; Marcellino D; Fuxe K; Ogren SO; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2012;102(3):517A

Dopamine D2 Receptor Antagonist Unbinding Rates Investigated using a Time-Resolved Ion Channel Activation Assay

Sahlholm K; Frisk S; Nilsson J; Marcellino D; Fuxe K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2012;102(3):134A

The Action of the Neuroprotective Compound Riluzole on Kv Channels

Nilsson J; Kempka M; Arhem P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21:S511-S512

Investigation of antagonist unbinding from dopamine D₂ receptors using a real-time ion channel activation assay

Sahlholm K; Frisk S; Fuxe K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2010;98(3):213A

Kv Channel Modulation: Closed State Block of Benzocaine But Not of Bupivacaine

Nilsson J; Madeja M; Sahlholm K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2010;98(3):290A

Agonist-Specific Effects of TM V Serine Mutations on Dopamine D2S Receptor Voltage-Sensitivity

Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2010;98(3):140a

Increasing the Potassium Channel Density in Regularly Spiking Pyramidal Cells can Turn them into Fast Spiking

Zeberg H; Arhem P
Review: CURRENT PROTEIN & PEPTIDE SCIENCE. 2007;8(5):460-470

Role of cooperativity in protein folding and protein mosaic assemblage relevance for protein conformational diseases

Agnati LF; Guidolin D; Leo G; Genedani S; Arhem P; Forni A; Andreoli N; Fuxe K
Published conference paper: BIOSYSTEMS. 2007;89(1-3):126-134

Density dependent neurodynamics.

Halnes G; Liljenström H; Arhem P
Published conference paper: BIOSYSTEMS. 2007;89(1-3):117-125

Ion channel density and threshold dynamics of repetitive firing in a cortical neuron model

Arhem P; Blomberg C
Review: BIOESSAYS. 2005;27(9):923-936

Evolution of the neural basis of consciousness: a bird-mammal comparison

Butler AB; Manger PR; Lindahl BIB; Arhem P
Review: LANCET. 2004;363(9416):1221-1223

Voltage sensing in ion channels:: a 50-year-old mystery resolved?

Århem P
Review: QUARTERLY REVIEWS OF BIOPHYSICS. 2003;36(4):373-427

Metal ion effects on ion channel gating

Elinder F; Århem P
Published conference paper: NEUROPSYCHOPHARMACOLOGY. 2003;28:S40-S47

Mechanisms of anesthesia:: Towards integrating network, cellular, and molecular level modeling

Århem P; Klement G; Nilsson J
Editorial comment: BIOSYSTEMS. 2001;63(1-3):1-2

Special issue -: Agora Meeting on Fluctuations in Biological Systems -: Part II -: Sigtuna, Sweden, August 3-7, 1999 -: Foreword

Århem P; Blomberg C; Liljenström H
Editorial comment: BIOSYSTEMS. 2001;62(1-3):1-2

Agora Meeting on Fluctuations in Biological Systems -: Part 1 -: Sigtuna, Sweden, August 3-7, 1999 -: Foreword

Århem P; Blomberg C; Liljenström H
Published conference paper: BIOSYSTEMS. 2001;62(1-3):29-43

Na channel kinetics:: developing current fluctuations by models from non-stationary analytic methods

Blomberg C; Elinder F; Århem P
Published conference paper: BIOSYSTEMS. 2001;62(1-3):13-28

Non-stationary fluctuation analysis of the Na current in myelinated nerve fibers of Xenopus laevis:: experiments and stochastic simulations

Elinder F; Frankenhaeuser B; Århem P
Editorial comment: JOURNAL OF THEORETICAL BIOLOGY. 1997;187(4):453-459

On the origin and evolution of life: An introduction

Baltscheffsky H; Blomberg C; Liljenstrom H; Lindahl BIB; Arhem P
Published conference paper: INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 1996;7(4):369-376

Spontaneous signalling in small central neurons: Mechanisms and roles of spike-amplitude and spike-interval fluctuations

Arhem P; Johansson S
Letter: JOURNAL OF THEORETICAL BIOLOGY. 1996;181(1):95-96

The relation between the conscious mind and the brain: A reply to Beck

Lindahl BIB; Arhem P
Letter: JOURNAL OF THEORETICAL BIOLOGY. 1996;180(1):87-89

Mind-brain interaction: comments on an article by B.I.B. Lindahl & P. Arhem.

Beck F
Letter: JOURNAL OF THEORETICAL BIOLOGY. 1996;178(2):225-226

The mental force field hypothesis: Reply

Lindahl BIB; Arhem P
Editorial comment: INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 1996;7(4):R7

Workshop on the Role and control of Random Events in Biological Systems - Foreword

Liljenstrom H; Arhem P; Blomberg C
Published conference paper: BIOSYSTEMS. 1996;38(2-3):191-198

Vertical information flow in the brain: On neuronal micro events and consciousness

Arhem P
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