Peter Århem

Publications
Public outreach and news

Articles

Article: SCIENTIFIC REPORTS. 2019;9(1):8175
Closed and open state dependent block of potassium channels cause opposing effects on excitability - a computational approach
Agren R; Nilsson J; Arhem P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2018;21(12):1102-1108
The Beta-Arrestin-Biased Dopamine D₂ Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation
Agren R; Arhem P; Nilsson J; Sahlholm K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;496(1):101-104
Point mutation of a conserved aspartate, D69, in the muscarinic M₂ receptor does not modify voltage-sensitive agonist potency
Agren R; Sahlholm K; Nilsson J; Arhem P
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2018;12:33
The Importance of the Dissociation Rate in Ion Channel Blocking
Zeberg H; Nilsson J; Arhem P
Article: BIOPHYSICAL JOURNAL. 2016;111(8):1679-1691
Extracellular Linkers Completely Transplant the Voltage Dependence from Kv1.2 Ion Channels to Kv2.1
Elinder F; Madeja M; Zeberg H; Arhem P
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2016;26(3):467-476
The fast-off hypothesis revisited: A functional kinetic study of antipsychotic antagonism of the dopamine D₂ receptor
Sahlholm K; Zeberg H; Nilsson J; Ogren SO; Fuxe K; Arhem P
Article: MOLECULAR PAIN. 2015;11:s12990-015-0044-z
G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy
Lyu C; Mulder J; Barde S; Sahlholm K; Zeberg H; Nilsson J; Arhem P; Hokfelt T; Fried K; Shi T-JS
Article: JOURNAL OF NEUROPHYSIOLOGY. 2015;113(2):537-549
Density of voltage-gated potassium channels is a bifurcation parameter in pyramidal neurons
Zeberg H; Robinson HPC; Arhem P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;17(1):149-155
Typical and atypical antipsychotics do not differ markedly in their reversibility of antagonism of the dopamine D₂ receptor
Sahlholm K; Marcellino D; Nilsson J; Ogren SO; Fuxe K; Arhem P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(2):690-695
Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db^-/db^- mouse, a type 2 diabetes model
Shi T-JS; Zhang M-D; Zeberg H; Nilsson J; Grunler J; Liu S-X; Xiang Q; Persson J; Fried KJ; Catrina SB; Watanabe M; Arhem P; Brismar K; Hokfelt TGM
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2012;1818(12):3081-3089
Voltage sensitivities and deactivation kinetics of histamine H₃ and H₄ receptors
Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: NEUROPHARMACOLOGY. 2011;61(5-6):937-949
Agonist-specific voltage sensitivity at the dopamine D_2S receptor - Molecular determinants and relevance to therapeutic ligands
Sahlholm K; Barchad-Avitzur O; Marcellino D; Gomez-Soler M; Fuxe K; Ciruela F; Arhem P
Article: JOURNAL OF NEUROPHYSIOLOGY. 2010;103(5):2900-2911
Spontaneous Ryanodine-Receptor-Dependent Ca²⁺-Activated K⁺ Currents and Hyperpolarizations in Rat Medial Preoptic Neurons
Klement G; Druzin M; Haage D; Malinina E; Arhem P; Johansson S
Article: PLOS COMPUTATIONAL BIOLOGY. 2010;6(4):e1000753
Ion Channel Density Regulates Switches between Regular and Fast Spiking in Soma but Not in Axons
Zeberg H; Blomberg C; Arhem P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;394(4):988-992
Cocaine produces D₂R-mediated conformational changes in the adenosine A_2AR-dopamine D₂R heteromer
Marcellino D; Navarro G; Sahlholm K; Nilsson J; Agnati LF; Canela EI; Lluis C; Arhem P; Franco R; Fuxe K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;377(4):1216-1221
Voltage-sensitivity at the human dopamine D_2S receptor is agonist-specific
Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Article: BIOPHYSICAL JOURNAL. 2008;95(11):5138-5152
Bupivacaine Blocks N-Type Inactivating K_v Channels in the Open State: No Allosteric Effect on Inactivation Kinetics
Nilsson J; Madeja M; Elinder F; Arhem P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;374(3):496-501
Differential voltage-sensitivity of D₂-like dopamine receptors
Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;591(1-3):52-58
Electrophysiology-based analysis of human histamine H₄ receptor pharmacology using GIRK channel coupling in Xenopus oocytes
Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: SYNAPSE. 2008;62(6):476-480
Voltage-dependence of the human dopamine D₂ receptor
Sahlholm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: BIOPHYSICAL JOURNAL. 2008;94(8):3014-3022
A tyrosine substitution in the cavity wall of a K channel induces an inverted inactivation
Klement G; Nilsson J; Arhem P; Elinder F
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):1-7
On the opening of voltage-gated ion channels
Elinder F; Nilsson J; Arhem P
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2007;567(3):206-210
The human histamine H₃ receptor couples to GIRK channels in Xenopus oocytes
Sahlhollm K; Nilsson J; Marcellino D; Fuxe K; Arhem P
Article: DIABETOLOGIA. 2007;50(8):1670-1677
Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters:: indications for a long-chain acyl-CoA ester binding motif
Braenstroem R; Leibiger IB; Leibiger B; Klement G; Nilsson J; Arhem P; Aspinwall CA; Corkey BE; Larsson O; Berggren R-O
Article: BIOPHYSICAL JOURNAL. 2006;90(12):4392-4404
Channel density regulation of firing patterns in a cortical neuron model
Arhem P; Klement G; Blomberg C
Article: BMC NEUROSCIENCE. 2005;6:65
A truncated Kv1.1 protein in the brain of the megencephaly mouse:: expression and interaction -: art. no. 65
Persson AS; Klement G; Almgren M; Sahlholm K; Nilsson J; Petersson S; Århem P; Schalling M; Lavebratt C
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2003;18(12):3231-3240
Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly
Petersson S; Persson AS; Johansen JE; Ingvar M; Nilsson J; Klement G; Århem P; Schalling M; Lavebratt C
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1652(1):35-51
Computational modelling of the open-state K_v1.5 ion channel block by bupivacaine
Luzhkov VB; Nilsson J; Århem P; Åqvist J
Article: MOLECULAR PHARMACOLOGY. 2003;63(6):1417-1429
Local anesthetic block of Kv channels:: Role of the S6 helix and the S5-S6 linker for bupivacaine action
Nilsson J; Madeja M; Århem P
Article: BIOPHYSICAL JOURNAL. 2001;80(4):1802-1809
Localization of the extracellular end of the voltage sensor S4 in a potassium channel
Elinder F; Århem P; Larsson HP
Article: LIFE SCIENCES. 2001;68(16):1817-1826
NMDA and glycine regulate the affinity of the Mg²⁺-block site in NR1-1a/NR2A NMDA receptor channels expressed in Xenopus oocytes
Liu Y; Hill RH; Århem P; von Euler G
Article: LAKARTIDNINGEN. 2000;97(30-31):3388-3390
[The Lasker Prize 1999. Molecular structure of ion channels as a theme of awarded research].
Arhem P
Article: BIOPHYSICAL JOURNAL. 1999;77(3):1358-1362
Role of individual surface charges of voltage-gated K channels
Elinder F; Århem P
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1998;360(1):21-29
Mechanisms of bupivacaine action on Na⁺ and K⁺ channels in myelinated axons of Xenopus laevis
Nilsson J; Elinder F; Århem P
Article: JOURNAL OF MEMBRANE BIOLOGY. 1998;165(2):183-189
Divalent cation effects on the shaker K channel suggest a pentapeptide sequence as determinant of functional surface charge density
Elinder F; Liu Y; Århem P
Article: JOURNAL OF MEMBRANE BIOLOGY. 1998;165(2):175-181
The functional surface charge density of a fast K channel in the myelinated axon of Xenopus laevis
Elinder F; Århem P
Article: JOURNAL OF THEORETICAL BIOLOGY. 1997;187(4):601-612
On the coevolution of cognition and consciousness
Arhem P; Liljenstrom H
Article: BIOPHYSICAL JOURNAL. 1997;73(1):179-185
Tail currents in the myelinated axon of Xenopus laevis suggest a two-open-state Na channel
Elinder F; Arhem P
Article: JOURNAL OF GENERAL PHYSIOLOGY. 1996;108(4):325-332
Surface charges of K channels - Effects of strontium on five cloned channels expressed in Xenopus oocytes
Elinder F; Madeja M; Arhem P
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Letter: MOLECULAR PSYCHIATRY. 2013;18(1):12-14
The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the σ-1 receptor
Sahlholm K; Arhem P; Fuxe K; Marcellino D
Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):126a
Local Anesthetics on Kv Channels - Closed State Binding of Bupivacaine?
Nilsson J; Zeberg H; Madeja M; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):26A
Novel Aspects of the Reversibility of the Antagonism at the Dopamine D2 Receptor by Antipsychotics
Sahlholm K; Frisk S; Nilsson J; Marcellino D; Fuxe K; Ogren SO; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2012;102(3):517A
Dopamine D2 Receptor Antagonist Unbinding Rates Investigated using a Time-Resolved Ion Channel Activation Assay
Sahlholm K; Frisk S; Nilsson J; Marcellino D; Fuxe K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2012;102(3):134a
The Action of the Neuroprotective Compound Riluzole on Kv Channels
Nilsson J; Kempka M; Arhem P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21:S511-S512
Investigation of antagonist unbinding from dopamine D₂ receptors using a real-time ion channel activation assay
Sahlholm K; Frisk S; Fuxe K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2010;98(3):140a
Increasing the Potassium Channel Density in Regularly Spiking Pyramidal Cells can Turn them into Fast Spiking
Zeberg H; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2010;98(3):290A
Agonist-Specific Effects of TM V Serine Mutations on Dopamine D2S Receptor Voltage-Sensitivity
Sahlholm K; Marcellino D; Nilsson J; Fuxe K; Arhem P
Meeting abstract: BIOPHYSICAL JOURNAL. 2010;98(3):213a
Kv Channel Modulation: Closed State Block of Benzocaine But Not of Bupivacaine
Nilsson J; Madeja M; Sahlholm K; Arhem P
Review: CURRENT PROTEIN & PEPTIDE SCIENCE. 2007;8(5):460-470
Role of cooperativity in protein folding and protein mosaic assemblage relevance for protein conformational diseases
Agnati LF; Guidolin D; Leo G; Genedani S; Arhem P; Forni A; Andreoli N; Fuxe K
Published conference paper: BIOSYSTEMS. 2007;89(1-3):126-134
Density dependent neurodynamics.
Halnes G; Liljenström H; Arhem P
Published conference paper: BIOSYSTEMS. 2007;89(1-3):117-125
Ion channel density and threshold dynamics of repetitive firing in a cortical neuron model
Arhem P; Blomberg C
Review: BIOESSAYS. 2005;27(9):923-936
Evolution of the neural basis of consciousness: a bird-mammal comparison
Butler AB; Manger PR; Lindahl BIB; Arhem P
Review: LANCET. 2004;363(9416):1221-1223
Voltage sensing in ion channels:: a 50-year-old mystery resolved?
Århem P
Review: QUARTERLY REVIEWS OF BIOPHYSICS. 2003;36(4):373-427
Metal ion effects on ion channel gating
Elinder F; Århem P
Published conference paper: NEUROPSYCHOPHARMACOLOGY. 2003;28:S40-S47
Mechanisms of anesthesia:: Towards integrating network, cellular, and molecular level modeling
Århem P; Klement G; Nilsson J
Editorial comment: BIOSYSTEMS. 2001;63(1-3):1-2
Special issue -: Agora Meeting on Fluctuations in Biological Systems -: Part II -: Sigtuna, Sweden, August 3-7, 1999 -: Foreword
Århem P; Blomberg C; Liljenström H
Editorial comment: BIOSYSTEMS. 2001;62(1-3):1-2
Agora Meeting on Fluctuations in Biological Systems -: Part 1 -: Sigtuna, Sweden, August 3-7, 1999 -: Foreword
Århem P; Blomberg C; Liljenström H
Published conference paper: BIOSYSTEMS. 2001;62(1-3):29-43
Na channel kinetics:: developing current fluctuations by models from non-stationary analytic methods
Blomberg C; Elinder F; Århem P
Published conference paper: BIOSYSTEMS. 2001;62(1-3):13-28
Non-stationary fluctuation analysis of the Na current in myelinated nerve fibers of Xenopus laevis:: experiments and stochastic simulations
Elinder F; Frankenhaeuser B; Århem P
Editorial comment: JOURNAL OF THEORETICAL BIOLOGY. 1997;187(4):453-459
On the origin and evolution of life: An introduction
Baltscheffsky H; Blomberg C; Liljenstrom H; Lindahl BIB; Arhem P
Published conference paper: INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 1996;7(4):369-376
Spontaneous signalling in small central neurons: Mechanisms and roles of spike-amplitude and spike-interval fluctuations
Arhem P; Johansson S
Letter: JOURNAL OF THEORETICAL BIOLOGY. 1996;181(1):95-96
The relation between the conscious mind and the brain: A reply to Beck
Lindahl BIB; Arhem P
Letter: JOURNAL OF THEORETICAL BIOLOGY. 1996;180(1):87-89
Mind-brain interaction: comments on an article by B.I.B. Lindahl & P. Arhem.
Beck F
Letter: JOURNAL OF THEORETICAL BIOLOGY. 1996;178(2):225-226
The mental force field hypothesis: Reply
Lindahl BIB; Arhem P
Editorial comment: INTERNATIONAL JOURNAL OF NEURAL SYSTEMS. 1996;7(4):R7
Workshop on the Role and control of Random Events in Biological Systems - Foreword
Liljenstrom H; Arhem P; Blomberg C
Published conference paper: BIOSYSTEMS. 1996;38(2-3):191-198
Vertical information flow in the brain: On neuronal micro events and consciousness
Arhem P
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