Paweł Kozielewicz

Paweł Kozielewicz

Assistant Professor | Team Leader
Visiting address: Solnavägen 9, Biomedicum, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Receptorbiologi, 171 77 Stockholm
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About me

  • I graduated with a Master’s of Pharmacy degree from the Medical University of Warsaw, Poland. Next, I did my PhD as a 

  • Marie Curie 
  • Fellow with Prof. Nicholas M. Barnes at the University of Birmingham and Celentyx Ltd., UK (immunological and neuropharmacological studies on therapeutical drugs and targets, including orphan G protein-coupled receptors, GPCRs).

    I had my first post-doctoral stay in the lab of Prof. Agnieszka Chacinska at the IIMCB, Warsaw, Poland (protein biogenesis in synaptoneurosomes). In August 2017, I joined Prof. Gunnar Schulte's lab for my second post-doc (pharmacology of class F Frizzleds GPCRs).

    In February 2022, I received a Higher doctorate in medical sciences from the Medical University of Lublin, Poland.

    I am currently setting up my independent lab, please see Molecular pharmacology of GPCRs and external lab website

Research

  • In my post-doctoral research in the Schulte lab, I focused on exploring the pharmacology of class F (Frizzleds) GPCRs by employing structural-functional analysis. It can be argued that, given certain ambiguities which exist about the molecular mechanism of action of these proteins, Frizzleds are similar to another class of the seven transmembrane-spanning receptors: orphan GPCRs. As such, in my prospective research, I will investigate the role of orphan GPCRs in health and diseases. For several diseases, some previous findings about a few orphan GPCRs have not been followed up by more thorough reports. Hence, the precise nature of orphan GPCRs' signalling and its association with a diseased state at a molecular level remain largely unknown. I aim to address these gaps in knowledge to push novel opportunities for therapies.

    Please check Molecular pharmacology of GPCRs website for more information.

Teaching

  • All at Karolinska Institutet:
    2023 - present: course responsible for the elective Advanced Receptor Pharmacology module

  • International Master’s Programme in Translational Physiology and Pharmacology


    2022- present: seminars on pharmacokinetics

  • Pharmacology and Toxicology course
  • Bachelor's Programme in Biomedicine
    2021 – present: supervision of students in the project on a literature search of a public health-related question
  • BV1 course
  • Läkarprogrammet
    2019 – 2022: seminars on pharmacokinetics and pharmacology of receptors
  • DSM2.1 course, Gamla läkarprogrammet

    2022 - completion of a 14-week 
  • “Teaching and learning in higher education, distance” course (Grundläggande högskolepedagogik, distant).

Articles

All other publications

Grants

  • Understanding the role of orphan GPCR GPR61 in obesity
    Karolinska Institutet Research Foundation
    25 November 2024 - 24 November 2026
  • Targeting G protein-coupled receptors in cancers
    Karolinska Institutet
    10 October 2024 - 9 October 2027
  • GPR34, GPR65 and GPR183 as therapeutic targets in blood cancers
    Jeansson Foundation
    13 December 2023 - 12 December 2024
  • Swedish Research Council
    1 January 2023 - 31 December 2026

Employments

  • Assistant Professor | Team Leader, Department of Physiology and Pharmacology, Karolinska Institutet, 2023-2029
  • Researcher, Department of Physiology and Pharmacology, Karolinska Institutet, 2022-2023
  • Post-doctoral researcher, Department of Physiology and Pharmacology, Karolinska Institutet, 2017-2022

Degrees and Education

  • Habilitation in Medical Sciences, Medical University of Lublin, 2022
  • PhD in Clinical and Experimental Medicine, University of Birmingham, 2017
  • Master's of Pharmacy, Medical University of Warsaw, 2013

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