Paweł Kozielewicz
About me
I graduated with a Master’s of Pharmacy degree from the Medical University of Warsaw, Poland. Next, I did my PhD as a
- Marie Curie
- Fellow with Prof. Nicholas M. Barnes at the University of Birmingham and Celentyx Ltd., UK (immunological and neuropharmacological studies on therapeutical drugs and targets, including orphan G protein-coupled receptors, GPCRs).
I had my first post-doctoral stay in the lab of Prof. Agnieszka Chacinska at the IIMCB, Warsaw, Poland (protein biogenesis in synaptoneurosomes). In August 2017, I joined Prof. Gunnar Schulte's lab for my second post-doc (pharmacology of class F Frizzleds GPCRs).
In February 2022, I received a Higher doctorate in medical sciences from the Medical University of Lublin, Poland.
I am currently setting up my independent lab, please see Molecular pharmacology of GPCRs and external lab website
Research
In my post-doctoral research in the Schulte lab, I focused on exploring the pharmacology of class F (Frizzleds) GPCRs by employing structural-functional analysis. It can be argued that, given certain ambiguities which exist about the molecular mechanism of action of these proteins, Frizzleds are similar to another class of the seven transmembrane-spanning receptors: orphan GPCRs. As such, in my prospective research, I will investigate the role of orphan GPCRs in health and diseases. For several diseases, some previous findings about a few orphan GPCRs have not been followed up by more thorough reports. Hence, the precise nature of orphan GPCRs' signalling and its association with a diseased state at a molecular level remain largely unknown. I aim to address these gaps in knowledge to push novel opportunities for therapies.
Please check Molecular pharmacology of GPCRs website for more information.
Teaching
All at Karolinska Institutet:
2023 - present: course responsible for the elective Advanced Receptor Pharmacology module- International Master’s Programme in Translational Physiology and Pharmacology
2022- present: seminars on pharmacokinetics - Pharmacology and Toxicology course
- Bachelor's Programme in Biomedicine
2021 – present: supervision of students in the project on a literature search of a public health-related question - BV1 course
- Läkarprogrammet
2019 – 2022: seminars on pharmacokinetics and pharmacology of receptors - DSM2.1 course, Gamla läkarprogrammet
2022 - completion of a 14-week - “Teaching and learning in higher education, distance” course (Grundläggande högskolepedagogik, distant).
Articles
- Article: BIOORGANIC CHEMISTRY. 2024;151:107681
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2024;181(20):3819-3835
- Journal article: BRITISH JOURNAL OF PHARMACOLOGY. 2024
- Journal article: SLAS DISCOVERY. 2024;29(6):100174
- Article: CELL REPORTS. 2024;43(2):113727
- Journal article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2024
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180:S23-S144
- Article: NATURE COMMUNICATIONS. 2023;14(1):4573
- Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2023;2023(1)
- Article: SCIENCE SIGNALING. 2023;16(779):eabo4974
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2374:195-204
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178:S27-S156
- Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2021;2021(3)
- Article: NATURE COMMUNICATIONS. 2021;12(1):3919
- Article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2021;4(3):1235-1245
- Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2021;269:101-115
- Article: MOLECULES. 2020;26(1):E143-143
- Journal article: FARMACJA POLSKA. 2020;76(10):592-599
- Article: EMBO REPORTS. 2020;21(8):e48882
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(26):8759-8774
- Article: NATURE COMMUNICATIONS. 2020;11(1):414
- Article: MOLECULAR PHARMACOLOGY. 2020;97(1):23-34
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(Suppl 1):S21-S141
- Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2019;2019(4)
- Journal article: FARMACJA POLSKA. 2019;75(8):451-456
- Article: NATURE COMMUNICATIONS. 2019;10(1):667
- Article: CHEMISTRYSELECT. 2018;3(33):9743-9752
- Article: FEBS OPEN BIO. 2017;7(12):1982-1993
- Article: STRUCTURAL CHEMISTRY. 2017;28(4):925-943
- Article: CHEMISTRYSELECT. 2016;1(10):2426-2438
- Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2016;2016:2573580
- Article: TETRAHEDRON. 2015;71(2):359-369
- Article: STRUCTURAL CHEMISTRY. 2014;25(6):1711-1723
- Article: MONATSHEFTE FUR CHEMIE. 2014;145(7):1201-1211
- Show more
All other publications
- Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2024;45(5):419-429
- Preprint: RESEARCH SQUARE. 2024
- Conference publication: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180(4):479-480
- Preprint: BIORXIV. 2022
- Preprint: BIORXIV. 2022
- Letter: CELL RESEARCH. 2021;31(12):1311-1314
- Review: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2020;126:17-24
- Review: MOLECULAR PHARMACOLOGY. 2020;97(2):62-71
- Preprint: BIORXIV. 2019
- Editorial comment: LIFE SCIENCES. 2019;225:132
- Conference publication: FEBS OPEN BIO. 2019;9:28-29
- Published conference paper: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2016;164:98-105
- Meeting abstract: PLANTA MEDICA. 2016;82:s1-s381
- Meeting abstract: PLANTA MEDICA. 2016;82:s1-s381
Grants
- Understanding the role of orphan GPCR GPR61 in obesityKarolinska Institutet Research Foundation25 November 2024 - 24 November 2026
- Targeting G protein-coupled receptors in cancersKarolinska Institutet10 October 2024 - 9 October 2027
- GPR34, GPR65 and GPR183 as therapeutic targets in blood cancersJeansson Foundation13 December 2023 - 12 December 2024
- Swedish Research Council1 January 2023 - 31 December 2026
Employments
- Assistant Professor | Team Leader, Department of Physiology and Pharmacology, Karolinska Institutet, 2023-2029
- Researcher, Department of Physiology and Pharmacology, Karolinska Institutet, 2022-2023
- Post-doctoral researcher, Department of Physiology and Pharmacology, Karolinska Institutet, 2017-2022
Degrees and Education
- Habilitation in Medical Sciences, Medical University of Lublin, 2022
- PhD in Clinical and Experimental Medicine, University of Birmingham, 2017
- Master's of Pharmacy, Medical University of Warsaw, 2013