Pauliina Damdimopoulou
Om mig
Med över 15 års erfarenhet inom endokrinologi, reproduktionsbiologi och toxikologi leder jag en forskargrupp vid Karolinska Institutet som undersöker effekterna av kemikalier på kvinnlig fertilitet. Min ambition är att generera evidensbaserad information om riskerna med kemisk exponering och farmaceutiska behandlingar för mänskliga äggstockar och äggceller, och därigenom bidra till utvecklingen av ett kemiskt säkrare samhälle.
Jag är även co-ledare för fokusområdet Environmental Endocrinology inom European Society of Endocrinology. Dessutom undervisar och handleder jag studenter på olika nivåer, deltar i universitetsadministration och engagerar mig i intressentverksamheter. Jag har mottagit flera forskningsbidrag och utmärkelser för min forskning, har tjänstgjort som vetenskaplig expert för nationella och internationella organisationer och jag presenterar ofta mitt arbete vid internationella konferenser.
Forskningsbeskrivning
Jag är intresserad av att studera effekter av läkemedel och miljökemikalier på fertiliteten hos kvinnor, med särskilt fokus på äggstocken.
Arbetet i min forskargrupp fokuserar på flera mål:
- vi kartlägger miljöexponeringar hos kvinnor och studerar samband mellan exponering och fertilitet
- vi undersöker effekterna av gonadotoxiska behandlingar, såsom kemoterapi, på äggstockar
- vi analyserar den molekylära och cellulära sammansättningen av mänskliga äggstockar genom livet
- vi undersöker hur miljö- och farmaceutiska exponeringar påverkar äggstockar genom att använda vävnadskulturmodeller
- vi utvecklar nya in vitro-verktyg för att förutsäga reproduktiv toxicitet av kemikalier i laboratoriet utan djurförsök.
Undervisning
Jag är docent i endokrin fysiologi (2015, Åbo Universitet, Finland) och toxikologi (2021, Karolinska Institutet) med undervisningserfarenhet i olika master- och doktorandkurser vid olika universitet i Sverige och Finland. Jag har handledt flera grundutbildningsstudenter genom deras praktiska laboratorieutbildning, samt masteruppsatsprojekt. Jag har också varit huvudhandledare för många doktorander och har lett dem till framgångsrika disputationer. Jag har formell utbildning i högre utbildningspedagogik, ledarskap och handledning av doktorander.
Artiklar
- Article: REPRODUCTIVE TOXICOLOGY. 2024;128:108660
- Article: ENVIRONMENT INTERNATIONAL. 2024;191:108960
- Article: NATURE COMMUNICATIONS. 2024;15(1):6989
- Article: TOXICOLOGY. 2024;505:153815
- Article: HUMAN REPRODUCTION OPEN. 2024;2024(3):hoae028
- Article: REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY. 2024;22(1):60
- Article: ENVIRONMENT INTERNATIONAL. 2024;187:108710
- Article: NATURE REVIEWS ENDOCRINOLOGY. 2024;20(4):187-188
- Article: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 2024;41(4):1035-1055
- Article: JOURNAL OF PROTEOME RESEARCH. 2024;23(1):238-248
- Article: OPEN RESEARCH EUROPE. 2024;4:68
- Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2023;578:112064
- Article: REPRODUCTIVE BIOMEDICINE ONLINE. 2023;47(4):103287
- Journal article: TOXICOLOGY LETTERS. 2023;384:s192-s193
- Article: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2023;33(5):699-709
- Article: ENVIRONMENT INTERNATIONAL. 2023;179:108141
- Article: SEMINARS IN REPRODUCTIVE MEDICINE. 2023;41(05):190-199
- Article: REPRODUCTIVE TOXICOLOGY. 2023;119:108416
- Article: REPRODUCTIVE TOXICOLOGY. 2023;119:108393
- Journal article: HUMAN REPRODUCTION. 2023;38(Supplement_1)
- Journal article: HUMAN REPRODUCTION. 2023;38(Supplement_1)
- Journal article: HUMAN REPRODUCTION. 2023;38(Supplement_1)
- Journal article: HUMAN REPRODUCTION. 2023;38(Supplement_1)
- Journal article: HUMAN REPRODUCTION. 2023;38(Supplement_1)
- Journal article: ENDOCRINE ABSTRACTS. 2023
- Article: JOURNAL OF PROTEOME RESEARCH. 2023;22(4):1071-1079
- Article: TOXICOLOGY. 2023;485:153425
- Article: FRONTIERS IN ENDOCRINOLOGY. 2023;14:1126485
- Article: ENVIRONMENTAL RESEARCH. 2023;216(Pt 1):114447
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(47):e2208886119
- Article: REPRODUCTIVE TOXICOLOGY. 2022;112:136-147
- Article: PHARMACEUTICS. 2022;14(6):1295
- Article: ENVIRONMENTAL RESEARCH. 2022;208:112626
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(9):4815
- Article: REPRODUCTIVE TOXICOLOGY. 2022;109:19-30
- Article: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 2022;39(4):905-918
- Article: SCIENCE. 2022;375(6582):eabe8244
- Article: MICROPLASTICS AND NANOPLASTICS. 2022;2(1):12
- Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:903505
- Article: TOXICOLOGY. 2021;464:153028
- Article: TOXICOLOGICAL SCIENCES. 2021;184(2):183-190
- Article: CHEMOSPHERE. 2021;283:131125
- Article: ENVIRONMENTAL SCIENCES: PROCESSES AND IMPACTS. 2021;23(10):1578-1588
- Article: ENVIRONMENT INTERNATIONAL. 2021;155:106589
- Article: BEST PRACTICE AND RESEARCH: CLINICAL ENDOCRINOLOGY AND METABOLISM. 2021;35(5):101552
- Article: DEVELOPMENTAL DYNAMICS. 2020;249(12):1500-1513
- Article: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 2020;37(9):2137-2150
- Article: ENVIRONMENTAL HEALTH: A GLOBAL ACCESS SCIENCE SOURCE. 2020;19(1):67
- Journal article: JOURNAL OF THE ENDOCRINE SOCIETY. 2020;4(Supplement_1):or31-or03
- Journal article: JOURNAL OF THE ENDOCRINE SOCIETY. 2020;4(Suppl 1)OR31-03 Single-Cell Profiling of Adult Human Ovarian Cortex Reveals Six Main Cell Types but No Germline Stem Cells
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(9):E3215-3215
- Article: MOLECULAR HUMAN REPRODUCTION. 2020;26(4):256-268
- Article: NATURE COMMUNICATIONS. 2020;11(1):1147
- Article: HUMAN REPRODUCTION. 2019;34(11):2297-2310
- Article: HUMAN REPRODUCTION. 2019;34(9):1674-1685
- Article: REPRODUCTIVE TOXICOLOGY. 2019;87:32-41
- Article: SCIENTIFIC REPORTS. 2019;9(1):8411
- Article: SCIENTIFIC REPORTS. 2019;9(1):6424
- Article: ENVIRONMENT INTERNATIONAL. 2019;124:482-492
- Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2018;478:77-83
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2018;338:73-82
- Article: SCIENTIFIC REPORTS. 2017;7(1):5317
- Article: ENDOCRINOLOGY. 2016;157(10):3719-3730
- Article: BEST PRACTICE AND RESEARCH: CLINICAL OBSTETRICS AND GYNAECOLOGY. 2016;31:2-12
- Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2015;231:44-52
- Article: BIOMATERIALS. 2014;35(30):8496-8502
- Article: ENVIRONMENTAL SCIENCE AND TECHNOLOGY. 2014;48(18):10919-10928
- Article: NATURE COMMUNICATIONS. 2014;5:3195
- Article: THE FASEB JOURNAL. 2013;27(4):1342-1350
- Article: TOXICOLOGICAL SCIENCES. 2012;127(1):66-75
- Article: JOURNAL OF NUTRITION. 2011;141(9):1583-1589
- Article: TOXICOLOGY LETTERS. 2011;202(2):75-84
- Article: PLOS ONE. 2011;6(8):e23048
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2010;118(10):1389-1394
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;176(3):1443-1451
- Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1793(10):1588-1596
- Article: MOLECULAR NUTRITION AND FOOD RESEARCH. 2009;53(8):996-1006
- Article: ENDOCRINOLOGY. 2007;148(10):4875-4886
- Article: REPRODUCTIVE TOXICOLOGY. 2007;23(3):397-406
- Article: PEDIATRIC RESEARCH. 2006;59(3):412-417
- Article: JOURNAL OF CHROMATOGRAPHY B: ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2004;813(1-2):303-312
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Alla övriga publikationer
- Conference publication: TOXICOLOGY LETTERS. 2023;384:s77-S80
- Editorial comment: STEM CELLS. 2023;41(2):105-110
- Letter: STEM CELLS. 2023;41(2):205-206
- Conference publication: TOXICOLOGY LETTERS. 2023;384:S77
- Conference publication: TOXICOLOGY LETTERS. 2023;384:S192-S193
- Conference publication: HUMAN REPRODUCTION. 2023;38
- Conference publication: HUMAN REPRODUCTION. 2023;38
- Conference publication: HUMAN REPRODUCTION. 2023;38
- Conference publication: HUMAN REPRODUCTION. 2023;38
- Conference publication: HUMAN REPRODUCTION. 2023;38
- Conference publication: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2023;102:65
- Conference publication: TOXICOLOGY LETTERS. 2022;368:S22
- Conference publication: TOXICOLOGY LETTERS. 2022;368:S178
- Conference publication: TOXICOLOGY LETTERS. 2022;368:S86
- Conference publication: TOXICOLOGY LETTERS. 2021;350:S169-S170
- Conference publication: TOXICOLOGY LETTERS. 2021;350:S48-S49
- Conference publication: REPRODUCTION IN DOMESTIC ANIMALS. 2021;56:7-8
- Review: ARCHIVES OF TOXICOLOGY. 2020;94(10):3359-3379
- Editorial comment: OBSTETRICAL AND GYNECOLOGICAL SURVEY. 2020;75(6):354-355
- Letter: HUMAN REPRODUCTION. 2020;35(5):1252-1253
- Review: UPSALA JOURNAL OF MEDICAL SCIENCES. 2020;125(2):85-94
- Review: HORMONE RESEARCH IN PAEDIATRICS. 2020;93(11-12):599-608
- Review: HUMAN REPRODUCTION UPDATE. 2019;25(6):777-801
- Preprint: BIORXIV. 2019
- Conference publication: TOXICOLOGY LETTERS. 2018;295:S63
- Preprint: BIORXIV. 2017
- Review: JOURNAL OF ENDOCRINOLOGY. 2016;228(2):R45-R56
- Editorial comment: OBSTETRICAL AND GYNECOLOGICAL SURVEY. 2016;71(1):29-30
- Letter: NATURE MEDICINE. 2015;21(10):1116-1118
- Conference publication: TOXICOLOGY LETTERS. 2013;221:S168
- Conference publication: TOXICOLOGY LETTERS. 2012;211:S38
- Book chapter: HORMONE-DISRUPTIVE CHEMICAL CONTAMINANTS IN FOOD. 2011;p. 44-69
- Editorial comment: ENDOCRINOLOGY. 2011;152(7):2542-2545
- Review: EXS. 2009;99:289-323
- Review: GENES AND NUTRITION. 2006;1(3-4):143-158
- Corrigendum: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2006;98(2-3):179
- Published conference paper: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2005;93(2-5):209-219
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Forskningsbidrag
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2022 - 31 December 2025
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2021 - 31 December 2023
- Swedish Research Council1 January 2021 - 31 December 2023
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 December 2018 - 30 November 2022
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2018 - 31 December 2020
- Swedish Research Council1 January 2018 - 31 December 2019
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2016 - 31 December 2018
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2016 - 31 December 2018
- Swedish Research Council1 January 2010 - 31 December 2010
Anställningar
- Lektor, Klinisk vetenskap, intervention och teknik, Karolinska Institutet, 2022-
- Postdoctoral researcher, R&D, Watchfrog (France), 2008-2010
Examina och utbildning
- Docent, Toxikologi, Karolinska Institutet, 2021