Oliver Mortusewicz

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: MOLECULAR ONCOLOGY. 2024;18(9):2179-2195
The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation
Marttila P; Bonagas N; Chalkiadaki C; Stigsdotter H; Schelzig K; Shen J; Farhat CM; Hondema A; Albers J; Wiita E; Rasti A; Warpman Berglund U; Slipicevic A; Mortusewicz O; Helleday T
Article: ONCOGENE. 2023;42(16):1282-1293
NUDT22 promotes cancer growth through pyrimidine salvage
Walter M; Mayr F; Hanna BMF; Cookson V; Mortusewicz O; Helleday T; Herr P
Article: NATURE METABOLISM. 2023;5(4):642-659
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
Green AC; Marttila P; Kiweler N; Chalkiadaki C; Wiita E; Cookson V; Lesur A; Eiden K; Bernardin F; Vallin KSA; Borhade S; Long M; Ghahe EK; Jimenez-Alonso JJ; Jemth A-S; Loseva O; Mortusewicz O; Meyers M; Viry E; Johansson AI; Hodek O; Homan E; Bonagas N; Ramos L; Sandberg L; Frodin M; Moussay E; Slipicevic A; Letellier E; Paggetti J; Sorensen CS; Helleday T; Henriksson M; Meiser J
Article: SCIENCE. 2022;376(6600):1471-1476
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Michel M; Benítez-Buelga C; Calvo PA; Hanna BMF; Mortusewicz O; Masuyer G; Davies J; Wallner O; Sanjiv K; Albers JJ; Castañeda-Zegarra S; Jemth A-S; Visnes T; Sastre-Perona A; Danda AN; Homan EJ; Marimuthu K; Zhenjun Z; Chi CN; Sarno A; Wiita E; von Nicolai C; Komor AJ; Rajagopal V; Müller S; Hank EC; Varga M; Scaletti ER; Pandey M; Karsten S; Haslene-Hox H; Loevenich S; Marttila P; Rasti A; Mamonov K; Ortis F; Schömberg F; Loseva O; Stewart J; D'Arcy-Evans N; Koolmeister T; Henriksson M; Michel D; de Ory A; Acero L; Calvete O; Scobie M; Hertweck C; Vilotijevic I; Kalderén C; Osorio A; Perona R; Stolz A; Stenmark P; Berglund UW; de Vega M; Helleday T
Article: NATURE COMMUNICATIONS. 2022;13(1):1015
Small Cajal body-associated RNA 2 (scaRNA2) regulates DNA repair pathway choice by inhibiting DNA-PK
Bergstrand S; O'Brien EM; Coucoravas C; Hrossova D; Peirasmaki D; Schmidli S; Dhanjal S; Pederiva C; Siggens L; Mortusewicz O; O'Rourke JJ; Farnebo M
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(9):4542
NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487
Hanna BMF; Michel M; Helleday T; Mortusewicz O
Article: NUCLEIC ACIDS RESEARCH (NAR). 2020;48(21):12234-12251
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Visnes T; Benitez-Buelga C; Cazares-Korner A; Sanjiv K; Hanna BMF; Mortusewicz O; Rajagopal V; Albers JJ; Hagey DW; Bekkhus T; Eshtad S; Baquero JM; Masuyer G; Wallner O; Muller S; Pham T; Gokturk C; Rasti A; Suman S; Torres-Ruiz R; Sarno A; Wiita E; Homan EJ; Karsten S; Marimuthu K; Michel M; Koolmeister T; Scobie M; Loseva O; Almlof I; Unterlass JE; Pettke A; Bostrom J; Pandey M; Gad H; Herr P; Jemth A-S; El Andaloussi S; Kalderen C; Rodriguez-Perales S; Benitez J; Krokan HE; Altun M; Stenmark P; Berglund UW; Helleday T
Article: BIOMOLECULES. 2020;10(11):E1483-1483
OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions
Hanna BMF; Helleday T; Mortusewicz O
Article: CANCER RESEARCH. 2020;80(17):3530-3541
MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Strom CE; Mortusewicz O; Berglund UW; Helleday T
Article: NUCLEIC ACIDS RESEARCH (NAR). 2019;47(14):7418-7429
Restriction of AID activity and somatic hypermutation by PARP-1
Tepper S; Mortusewicz O; Czlonka E; Bello A; Schmidt A; Jeschke J; Fischbach A; Pfeil I; Petersen-Mahrt SK; Mangerich A; Helleday T; Leonhardt H; Jungnickel B
Journal article: HEMASPHERE. 2019;3(S1):67
PF230 THE RNA HELICASE DDX17 PROTECTS ACUTE MYELOID LEUKEMIA CELLS AGAINST DNA DAMAGE
Jagdhane P; Garg S; Xia J; He L; Misiak D; Mortusewicz O; Helleday T; Müller‐Tidow C; Koehn M; Pabst C
Article: NUCLEUS. 2019;10(1):231-253
Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair
Chagin VO; Reinhart B; Becker A; Mortusewicz O; Jost KL; Rapp A; Leonhardt H; Cardoso MC
Article: SCIENCE. 2018;362(6416):834-839
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
Visnes T; Cazares-Korner A; Hao W; Wallner O; Masuyer G; Loseva O; Mortusewicz O; Wiita E; Sarno A; Manoilov A; Astorga-Wells J; Jemth A-S; Pan L; Sanjiv K; Karsten S; Gokturk C; Grube M; Homan EJ; Hanna BMF; Paulin CBJ; Pham T; Rasti A; Berglund UW; von Nicolai C; Benitez-Buelga C; Koolmeister T; Ivanic D; Iliev P; Scobie M; Krokan HE; Baranczewski P; Artursson P; Altun M; Jensen AJ; Kalderen C; Ba X; Zubarev RA; Stenmark P; Boldogh I; Helleday T
Article: ONCOTARGET. 2017;8(14):23713-23726
dUTPase inhibition augments replication defects of 5-Fluorouracil
Hagenkort A; Paulin CBJ; Desroses M; Sarno A; Wiita E; Mortusewicz O; Koolmeister T; Loseva O; Jemth A-S; Almlof I; Homan E; Lundback T; Gustavsson A-L; Scobie M; Helleday T
Article: CELL CYCLE. 2017;16(2):189-199
Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion
Sokolova M; Turunen M; Mortusewicz O; Kivioja T; Herr P; Vaharautio A; Bjorklund M; Taipale M; Helleday T; Taipale J
Article: ONCOGENESIS. 2016;5(12):e280
The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing
Tanikawa M; Sanjiv K; Helleday T; Herr P; Mortusewicz O
Article: CANCER RESEARCH. 2016;76(5):1078-1088
DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair
Ying S; Chen Z; Medhurst AL; Neal JA; Bao Z; Mortusewicz O; McGouran J; Song X; Shen H; Hamdy FC; Kessler BM; Meek K; Helleday T
Article: ONCOGENE. 2016;35(6):761-770
PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites
Mortusewicz O; Evers B; Helleday T
Article: CELL REPORTS. 2016;14(2):298-309
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
Sanjiv K; Hagenkort A; Calderon-Montano JM; Koolmeister T; Reaper PM; Mortusewicz O; Jacques SA; Kuiper RV; Schultz N; Scobie M; Charlton PA; Pollard JR; Berglund UW; Altun M; Helleday T
Article: MOLECULAR CELL. 2015;60(1):163-176
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair
Xie S; Mortusewicz O; Ma HT; Herr P; Poon RRY; Helleday T; Qian C
Article: FEBS OPEN BIO. 2015;5:779-788
Generation of an alpaca-derived nanobody recognizing γ-H2AX.
Rajan M; Mortusewicz O; Rothbauer U; Hastert FD; Schmidthals K; Rapp A; Leonhardt H; Cardoso MC
Article: CELL DISCOVERY. 2015;1:15034
A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair
Herr P; Lundin C; Evers B; Ebner D; Bauerschmidt C; Kingham G; Palmai-Pallag T; Mortusewicz O; Frings O; Sonnhammer E; Helleday T
Article: ONCOGENE. 2013;32(32):3744-3753
Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress
Jones RM; Mortusewicz O; Afzal I; Lorvellec M; Garcia P; Helleday T; Petermann E
Article: NUCLEIC ACIDS RESEARCH (NAR). 2011;39(19):8445-8456
Role for hACF1 in the G2/M damage checkpoint.
Sánchez-Molina S; Mortusewicz O; Bieber B; Auer S; Eckey M; Leonhardt H; Friedl AA; Becker PB
Article: DNA REPAIR. 2011;10(9):961-969
CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair
Strom CE; Mortusewicz O; Finch D; Parsons JL; Lagerqvist A; Johansson F; Schultz N; Erixon K; Dianov GL; Helleday T
Article: NUCLEIC ACIDS RESEARCH (NAR). 2011;39(12):5045-5056
PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms.
Mortusewicz O; Fouquerel E; Amé J-C; Leonhardt H; Schreiber V
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(7):2783-2788
Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression.
Boehler C; Gauthier LR; Mortusewicz O; Biard DS; Saliou J-M; Bresson A; Sanglier-Cianferani S; Smith S; Schreiber V; Boussin F; Dantzer F
Article: DEVELOPMENT. 2009;136(13):2277-2286
MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos.
Ruzov A; Shorning B; Mortusewicz O; Dunican DS; Leonhardt H; Meehan RR
Article: JOURNAL OF CELL BIOLOGY. 2008;183(5):769-776
Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites.
Mortusewicz O; Roth W; Li N; Cardoso MC; Meisterernst M; Leonhardt H
Article: MOLECULAR & CELLULAR PROTEOMICS. 2008;7(11):2279-2287
A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells.
Zolghadr K; Mortusewicz O; Rothbauer U; Kleinhans R; Goehler H; Wanker EE; Cardoso MC; Leonhardt H
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2008;104(5):1562-1569
Spatiotemporal dynamics of regulatory protein recruitment at DNA damage sites.
Mortusewicz O; Leonhardt H; Cardoso MC
Article: NUCLEIC ACIDS RESEARCH (NAR). 2007;35(22):7665-7675
Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells.
Mortusewicz O; Amé J-C; Schreiber V; Leonhardt H
Article: BMC MOLECULAR BIOLOGY. 2007;8:81
XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions.
Mortusewicz O; Leonhardt H
Article: NUCLEIC ACIDS RESEARCH (NAR). 2006;34(12):3523-3532
Differential recruitment of DNA Ligase I and III to DNA repair sites.
Mortusewicz O; Rothbauer U; Cardoso MC; Leonhardt H
Article: JOURNAL OF CELL SCIENCE. 2006;119(Pt 8):1517-1527
Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen.
Perucca P; Cazzalini O; Mortusewicz O; Necchi D; Savio M; Nardo T; Stivala LA; Leonhardt H; Cardoso MC; Prosperi E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(25):8905-8909
Recruitment of DNA methyltransferase I to DNA repair sites.
Mortusewicz O; Schermelleh L; Walter J; Cardoso MC; Leonhardt H
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Other: JOURNAL OF CELL SCIENCE. 2022;135(21):jcs260709
Expression of Concern: Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen.
Perucca P; Cazzalini O; Mortusewicz O; Necchi D; Savio M; Nardo T; Stivala LA; Leonhardt H; Cardoso MC; Prosperi E
Preprint: BIORXIV. 2022
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM
Valerie NCK; Sanjiv K; Mortusewicz O; Zhang SM; Alam S; Pires M; Stigsdotter H; Rasti A; Langelier M-F; Langelier M-F; Rehling D; Throup A; Desroses M; Onireti J; Wakchaure P; Almlöf I; Boström J; Bevc L; Benzi G; Stenmark P; Pascal J; Helleday T; Page BDG; Altun M
Preprint: BIORXIV. 2019
MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells
Gad H; Mortusewicz O; Rudd S; Stolz A; Amaral N; Brautigham L; Pudelko L; Sanjiv K; Kaldéren C; Jemth A-S; Almlöf I; Visnes T; Schultz N; Boström J; Calderon Montano JM; Hagenkort A; Groth P; Loseva O; Gokturk C; Koolmeister T; Wakchaure P; Homan E; Ström C; Scobie M; Bastians H; Berglund UW; Helleday T
Corrigendum: CELL REPORTS. 2016;17(12):3407-3416
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities (vol 14, pg 298, 2016)
Sanjiv K; Hagenkort A; Calderon-Montano JM; Koolmeister T; Reaper PM; Mortusewicz O; Jacques SA; Kuiper RV; Schultz N; Scobie M; Charlton PA; Pollard JR; Berglund UW; Altun M; Helleday T
Corrigendum: MOLECULAR CELL. 2016;61(1):181
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair (vol 60, pg 163, 2015)
Xie S; Mortusewicz O; Ma HT; Herr P; Poon RYC; Helleday T; Qian C
Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2014;50:81
The combination of Chk-1 and ATR inhibitor synergistically kills cancer cells
Sanjiv K; Hagenkort A; Reaper PM; Koolmeister T; Mortusewicz O; Schultz N; Scobie M; Berglund UW; Charlton PA; Pollard JR; Helleday T
Editorial comment: EMBO JOURNAL. 2013;32(4):493-495
Early replication fragile sites: where replication-transcription collisions cause genetic instability
Mortusewicz O; Herr P; Helleday T

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