Oliver Mortusewicz
Principal Researcher
E-mail: oliver.mortusewicz@ki.se
Visiting address: Scilifelab, Alpha Building Level 4, Tomtebodavägen 23a, 17165 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Helleday Mortusewicz, 171 77 Stockholm
Part of:
- Department of Oncology-Pathology
- The Helleday Laboratory focuses on harnessing defects in the DNA damage response and metabolism to develop novel therapies
About me
- Principal Researcher, Team leader and Project leader at the Department of Oncology-Pathology & SciLifeLab
Research
- A deep understanding of the molecular mechanisms of DNA repair and nucleotide metabolism is the cornerstone of our drug discovery approach.
To be able to efficiently and successfully target proteins involved in these pathways for the treatment of cancer and other diseases, we need a detailed view of their biological functions and interactions in live cells.
We have the unique ability to use small molecule Inhibitors and Activators developed by our excellent medicinal chemistry team as probes in our advanced molecular and cell biology assays to uncover new important biology.
We regularly employ advanced live cell confocal microscopy in combination with laser microirradiation, Fluorescence recovery after photobleaching (FRAP) and Fluorescence loss in photobleaching (FLIP) to visualize high spatio-temporal details and highly coordinated processes of DNA repair, cell division and genome duplication in live cells. This is complemented by traditional antibody-based immunofluorescence assays in tumors and cells, allowing visualization of endogenous protein distribution and post-translational modifications after perturbation with drugs. Besides high-resolution confocal microscopy we use plate-reader microscopes for quantitative image based cytometry (QIBC), enabling us to test many different experimental settings and perturbations on a high number of cells.
Teaching
- • Co-Supervison of four PhD Students to date
• Supervision of undergraduate & MSc thesis projects
Articles
- Article: NATURE COMMUNICATIONS. 2025;16(1):1741Luttens A; Vo DD; Scaletti ER; Wiita E; Almlof I; Wallner O; Davies J; Kosenina S; Meng L; Long M; Mortusewicz O; Masuyer G; Ballante F; Michel M; Homan E; Scobie M; Kalderen C; Berglund UW; Tarnovskiy AV; Radchenko DS; Moroz YS; Kihlberg J; Stenmark P; Helleday T; Carlsson J
- Article: NATURE COMMUNICATIONS. 2024;15(1):10347Valerie NCK; Sanjiv K; Mortusewicz O; Zhang SM; Alam S; Pires MJ; Stigsdotter H; Rasti A; Langelier M-F; Rehling D; Throup A; Purewal-Sidhu O; Desroses M; Onireti J; Wakchaure P; Almloef I; Bostrom J; Bevc L; Benzi G; Stenmark P; Pascal JM; Helleday T; Page BDG; Altun M
- Article: MOLECULAR ONCOLOGY. 2024;18(9):2179-2195Marttila P; Bonagas N; Chalkiadaki C; Stigsdotter H; Schelzig K; Shen J; Farhat CM; Hondema A; Albers J; Wiita E; Rasti A; Warpman Berglund U; Slipicevic A; Mortusewicz O; Helleday T
- Journal article: MOLECULAR CANCER THERAPEUTICS. 2023;22(12_Supplement):b109Martilla P; Green AC; Kiweler N; Chalkiadaki C; Wiita E; Cookson V; Lesur A; Eiden K; Bernhardin F; Long M; Jemth A-S; Mortusewicz O; Homan E; Bonagas N; Ramos L; Sanjiv K; Mancina EG; Pham T; Slipicevic A; Henriksson M; Meiser J; Helleday T
- Article: ONCOGENE. 2023;42(16):1282-1293Walter M; Mayr F; Hanna BMF; Cookson V; Mortusewicz O; Helleday T; Herr P
- Article: NATURE METABOLISM. 2023;5(4):642-659Green AC; Marttila P; Kiweler N; Chalkiadaki C; Wiita E; Cookson V; Lesur A; Eiden K; Bernardin F; Vallin KSA; Borhade S; Long M; Ghahe EK; Jimenez-Alonso JJ; Jemth A-S; Loseva O; Mortusewicz O; Meyers M; Viry E; Johansson AI; Hodek O; Homan E; Bonagas N; Ramos L; Sandberg L; Frodin M; Moussay E; Slipicevic A; Letellier E; Paggetti J; Sorensen CS; Helleday T; Henriksson M; Meiser J
- Article: SCIENCE. 2022;376(6600):1471-1476Michel M; Benítez-Buelga C; Calvo PA; Hanna BMF; Mortusewicz O; Masuyer G; Davies J; Wallner O; Sanjiv K; Albers JJ; Castañeda-Zegarra S; Jemth A-S; Visnes T; Sastre-Perona A; Danda AN; Homan EJ; Marimuthu K; Zhenjun Z; Chi CN; Sarno A; Wiita E; von Nicolai C; Komor AJ; Rajagopal V; Müller S; Hank EC; Varga M; Scaletti ER; Pandey M; Karsten S; Haslene-Hox H; Loevenich S; Marttila P; Rasti A; Mamonov K; Ortis F; Schömberg F; Loseva O; Stewart J; D'Arcy-Evans N; Koolmeister T; Henriksson M; Michel D; de Ory A; Acero L; Calvete O; Scobie M; Hertweck C; Vilotijevic I; Kalderén C; Osorio A; Perona R; Stolz A; Stenmark P; Berglund UW; de Vega M; Helleday T
- Article: NATURE COMMUNICATIONS. 2022;13(1):1015Small Cajal body-associated RNA 2 (scaRNA2) regulates DNA repair pathway choice by inhibiting DNA-PKBergstrand S; O'Brien EM; Coucoravas C; Hrossova D; Peirasmaki D; Schmidli S; Dhanjal S; Pederiva C; Siggens L; Mortusewicz O; O'Rourke JJ; Farnebo M
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(9):4542Hanna BMF; Michel M; Helleday T; Mortusewicz O
- Article: NUCLEIC ACIDS RESEARCH. 2020;48(21):12234-12251Visnes T; Benitez-Buelga C; Cazares-Korner A; Sanjiv K; Hanna BMF; Mortusewicz O; Rajagopal V; Albers JJ; Hagey DW; Bekkhus T; Eshtad S; Baquero JM; Masuyer G; Wallner O; Muller S; Pham T; Gokturk C; Rasti A; Suman S; Torres-Ruiz R; Sarno A; Wiita E; Homan EJ; Karsten S; Marimuthu K; Michel M; Koolmeister T; Scobie M; Loseva O; Almlof I; Unterlass JE; Pettke A; Bostrom J; Pandey M; Gad H; Herr P; Jemth A-S; El Andaloussi S; Kalderen C; Rodriguez-Perales S; Benitez J; Krokan HE; Altun M; Stenmark P; Berglund UW; Helleday T
- Article: BIOMOLECULES. 2020;10(11):E1483-1483Hanna BMF; Helleday T; Mortusewicz O
- Article: CANCER RESEARCH. 2020;80(17):3530-3541Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Strom CE; Mortusewicz O; Berglund UW; Helleday T
- Article: NUCLEIC ACIDS RESEARCH. 2019;47(14):7418-7429Tepper S; Mortusewicz O; Czlonka E; Bello A; Schmidt A; Jeschke J; Fischbach A; Pfeil I; Petersen-Mahrt SK; Mangerich A; Helleday T; Leonhardt H; Jungnickel B
- Journal article: HEMASPHERE. 2019;3(S1):67Jagdhane P; Garg S; Xia J; He L; Misiak D; Mortusewicz O; Helleday T; Müller‐Tidow C; Koehn M; Pabst C
- Article: NUCLEUS. 2019;10(1):231-253Chagin VO; Reinhart B; Becker A; Mortusewicz O; Jost KL; Rapp A; Leonhardt H; Cardoso MC
- Article: SCIENCE. 2018;362(6416):834-839Visnes T; Cazares-Korner A; Hao W; Wallner O; Masuyer G; Loseva O; Mortusewicz O; Wiita E; Sarno A; Manoilov A; Astorga-Wells J; Jemth A-S; Pan L; Sanjiv K; Karsten S; Gokturk C; Grube M; Homan EJ; Hanna BMF; Paulin CBJ; Pham T; Rasti A; Berglund UW; von Nicolai C; Benitez-Buelga C; Koolmeister T; Ivanic D; Iliev P; Scobie M; Krokan HE; Baranczewski P; Artursson P; Altun M; Jensen AJ; Kalderen C; Ba X; Zubarev RA; Stenmark P; Boldogh I; Helleday T
- Article: ONCOTARGET. 2017;8(14):23713-23726Hagenkort A; Paulin CBJ; Desroses M; Sarno A; Wiita E; Mortusewicz O; Koolmeister T; Loseva O; Jemth A-S; Almlof I; Homan E; Lundback T; Gustavsson A-L; Scobie M; Helleday T
- Article: CELL CYCLE. 2017;16(2):189-199Sokolova M; Turunen M; Mortusewicz O; Kivioja T; Herr P; Vaharautio A; Bjorklund M; Taipale M; Helleday T; Taipale J
- Article: ONCOGENESIS. 2016;5(12):e280Tanikawa M; Sanjiv K; Helleday T; Herr P; Mortusewicz O
- Article: CANCER RESEARCH. 2016;76(5):1078-1088Ying S; Chen Z; Medhurst AL; Neal JA; Bao Z; Mortusewicz O; McGouran J; Song X; Shen H; Hamdy FC; Kessler BM; Meek K; Helleday T
- Article: ONCOGENE. 2016;35(6):761-770Mortusewicz O; Evers B; Helleday T
- Article: CELL REPORTS. 2016;14(2):298-309Sanjiv K; Hagenkort A; Calderon-Montano JM; Koolmeister T; Reaper PM; Mortusewicz O; Jacques SA; Kuiper RV; Schultz N; Scobie M; Charlton PA; Pollard JR; Berglund UW; Altun M; Helleday T
- Journal article: BIO-PROTOCOL. 2016;6(23)Tampere M; Mortusewicz O
- Article: MOLECULAR CELL. 2015;60(1):163-176Xie S; Mortusewicz O; Ma HT; Herr P; Poon RRY; Helleday T; Qian C
- Article: CELL DISCOVERY. 2015;1:15034Herr P; Lundin C; Evers B; Ebner D; Bauerschmidt C; Kingham G; Palmai-Pallag T; Mortusewicz O; Frings O; Sonnhammer E; Helleday T
- Article: FEBS OPEN BIO. 2015;5:779-788Rajan M; Mortusewicz O; Rothbauer U; Hastert FD; Schmidthals K; Rapp A; Leonhardt H; Cardoso MC
- Article: ONCOGENE. 2013;32(32):3744-3753Jones RM; Mortusewicz O; Afzal I; Lorvellec M; Garcia P; Helleday T; Petermann E
- Article: NUCLEIC ACIDS RESEARCH. 2011;39(19):8445-8456Sánchez-Molina S; Mortusewicz O; Bieber B; Auer S; Eckey M; Leonhardt H; Friedl AA; Becker PB
- Article: DNA REPAIR. 2011;10(9):961-969Strom CE; Mortusewicz O; Finch D; Parsons JL; Lagerqvist A; Johansson F; Schultz N; Erixon K; Dianov GL; Helleday T
- Article: NUCLEIC ACIDS RESEARCH. 2011;39(12):5045-5056Mortusewicz O; Fouquerel E; Amé J-C; Leonhardt H; Schreiber V
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(7):2783-2788Boehler C; Gauthier LR; Mortusewicz O; Biard DS; Saliou J-M; Bresson A; Sanglier-Cianferani S; Smith S; Schreiber V; Boussin F; Dantzer F
- Article: DEVELOPMENT. 2009;136(13):2277-2286Ruzov A; Shorning B; Mortusewicz O; Dunican DS; Leonhardt H; Meehan RR
- Article: JOURNAL OF CELL BIOLOGY. 2008;183(5):769-776Mortusewicz O; Roth W; Li N; Cardoso MC; Meisterernst M; Leonhardt H
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2008;7(11):2279-2287Zolghadr K; Mortusewicz O; Rothbauer U; Kleinhans R; Goehler H; Wanker EE; Cardoso MC; Leonhardt H
- Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2008;104(5):1562-1569Mortusewicz O; Leonhardt H; Cardoso MC
- Article: NUCLEIC ACIDS RESEARCH. 2007;35(22):7665-7675Mortusewicz O; Amé J-C; Schreiber V; Leonhardt H
- Article: BMC MOLECULAR BIOLOGY. 2007;8:81Mortusewicz O; Leonhardt H
- Article: NUCLEIC ACIDS RESEARCH. 2006;34(12):3523-3532Mortusewicz O; Rothbauer U; Cardoso MC; Leonhardt H
- Article: JOURNAL OF CELL SCIENCE. 2006;119(Pt 8):1517-1527Perucca P; Cazzalini O; Mortusewicz O; Necchi D; Savio M; Nardo T; Stivala LA; Leonhardt H; Cardoso MC; Prosperi E
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(25):8905-8909Mortusewicz O; Schermelleh L; Walter J; Cardoso MC; Leonhardt H
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All other publications
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Ström CE; Mortusewicz O; Berglund UW; Helleday T
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Ström CE; Mortusewicz O; Berglund UW; Helleday T
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Ström CE; Mortusewicz O; Berglund UW; Helleday T
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Ström CE; Mortusewicz O; Berglund UW; Helleday T
- Other: JOURNAL OF CELL SCIENCE. 2022;135(21):jcs260709Perucca P; Cazzalini O; Mortusewicz O; Necchi D; Savio M; Nardo T; Stivala LA; Leonhardt H; Cardoso MC; Prosperi E
- Preprint: BIORXIV. 2022Valerie NCK; Sanjiv K; Mortusewicz O; Zhang SM; Alam S; Pires M; Stigsdotter H; Rasti A; Langelier M-F; Langelier M-F; Rehling D; Throup A; Desroses M; Onireti J; Wakchaure P; Almlöf I; Boström J; Bevc L; Benzi G; Stenmark P; Pascal J; Helleday T; Page BDG; Altun M
- Conference publication: 2021;:9213Helleday T; Hanna BMF; Visnes T; Benitez-Buelga C; Cazares-Körner A; Sanjiv K; Mortusewicz O; Masuyer G; Wallner O; Michel M; Loseva O; Jemth A-S; Kalderen C; Stenmark P; Berglund UW
- Meeting abstract: CANCER RESEARCH. 2020;80(16):5204Benitez-Buelga C; Visnes T; Sanjiv K; Mortusewicz O; Berglund UW; Helleday T
- Meeting abstract: CANCER RESEARCH. 2019;79(13):105Sanjiv K; Gad H; Rudd SG; Mortusewicz O; Stolz A; Amaral N; Brautigham L; Pudelko L; Kalderen C; Jemth A-S; Almlof I; Visnes T; Schultz N; Bostrom J; Montano JMC; Hagenkort A; Groth P; Gokturk C; Koolmeister T; Wakchaure P; Homan E; Altun M; Strom C; Scobie M; Bastians H; Berglund UW; Helleday T
- Preprint: BIORXIV. 2019Gad H; Mortusewicz O; Rudd S; Stolz A; Amaral N; Brautigham L; Pudelko L; Sanjiv K; Kaldéren C; Jemth A-S; Almlöf I; Visnes T; Schultz N; Boström J; Calderon Montano JM; Hagenkort A; Groth P; Loseva O; Gokturk C; Koolmeister T; Wakchaure P; Homan E; Ström C; Scobie M; Bastians H; Berglund UW; Helleday T
- Preprint: BIORXIV. 2019Rudd S; Gad H; Amaral N; Hagenkort A; Groth P; Ström C; Mortusewicz O; Berglund UW; Helleday T
- Corrigendum: CELL REPORTS. 2016;17(12):3407-3416Sanjiv K; Hagenkort A; Calderon-Montano JM; Koolmeister T; Reaper PM; Mortusewicz O; Jacques SA; Kuiper RV; Schultz N; Scobie M; Charlton PA; Pollard JR; Berglund UW; Altun M; Helleday T
- Corrigendum: MOLECULAR CELL. 2016;61(1):181Xie S; Mortusewicz O; Ma HT; Herr P; Poon RYC; Helleday T; Qian C
- Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2014;50:81Sanjiv K; Hagenkort A; Reaper PM; Koolmeister T; Mortusewicz O; Schultz N; Scobie M; Berglund UW; Charlton PA; Pollard JR; Helleday T
- Editorial comment: EMBO JOURNAL. 2013;32(4):493-495Mortusewicz O; Herr P; Helleday T