Ola Larsson

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: MOLECULAR AUTISM. 2023;14(1):39
Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations
Aksoylu IS; Martin P; Robert F; Szkop KJ; Redmond NE; Bhattacharyya S; Wang J; Chen S; Beauchamp RL; Nobeli I; Pelletier J; Larsson O; Ramesh V
Article: SCIENCE ADVANCES. 2023;9(30):eadg1805
Control of protein synthesis through mRNA pseudouridylation by dyskerin
Pederiva C; Trevisan DM; Peirasmaki D; Chen S; Savage SA; Larsson O; Ule J; Baranello L; Agostini F; Farnebo M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2023;654:73-79
An extracellular matrix stiffness-induced breast cancer cell transcriptome resembles the transition from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC)
Goransson S; Chen S; Olofsson H; Larsson O; Stromblad S
Article: NATURE CHEMICAL BIOLOGY. 2022;18(9):942-953
MNK2 deficiency potentiates β-cell regeneration via translational regulation
Karampelias C; Watt K; Mattsson CL; Ruiz AF; Rezanejad H; Mi J; Liu X; Chu L; Locasale JW; Korbutt GS; Rovira M; Larsson O; Andersson O
Article: CELL REPORTS. 2022;40(3):111092
Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
Krokowski D; Jobava R; Szkop KJ; Chen C-W; Fu X; Venus S; Guan B-J; Wu J; Gao Z; Banaszuk W; Tchorzewski M; Mu T; Ropelewski P; Merrick WC; Mao Y; Sevval AI; Miranda H; Qian S-B; Manifava M; Ktistakis NT; Vourekas A; Jankowsky E; Topisirovic I; Larsson O; Hatzoglou M
Article: CELL METABOLISM. 2022;34(4):564-580.e8
Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure
Katsumura S; Siddiqui N; Goldsmith MR; Cheah JH; Fujikawa T; Minegishi G; Yamagata A; Yabuki Y; Kobayashi K; Shirouzu M; Inagaki T; Huang TH-M; Musi N; Topisirovic I; Larsson O; Morita M
Article: EMBO JOURNAL. 2022;41(6):e108650
PABP prevents the untimely decay of select mRNA populations in human cells
Kajjo S; Sharma S; Chen S; Brothers WR; Cott M; Hasaj B; Jovanovic P; Larsson O; Fabian MR
Article: NATURE COMMUNICATIONS. 2022;13(1):1100
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF^V600 melanoma
Smith LK; Parmenter T; Kleinschmidt M; Kusnadi EP; Kang J; Martin CA; Lau P; Patel R; Lorent J; Papadopoli D; Trigos A; Ward T; Rao AD; Lelliott EJ; Sheppard KE; Goode D; Hicks RJ; Tiganis T; Simpson KJ; Larsson O; Blythe B; Cullinane C; Wickramasinghe VO; Pearson RB; McArthur GA
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:243-268
Anota2seq Analysis for Transcriptome-Wide Studies of mRNA Translation.
Oertlin C; Watt K; Ristau J; Larsson O
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:223-241
Polysome Fractionation for Transcriptome-Wide Studies of mRNA Translation.
Ristau J; Watt K; Oertlin C; Larsson O
Article: NATURE CHEMICAL BIOLOGY. 2021;17(10):1065-1074
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth
Lee BJ; Boyer JA; Burnett GL; Thottumkara AP; Tibrewal N; Wilson SL; Hsieh T; Marquez A; Lorenzana EG; Evans JW; Hulea L; Kiss G; Liu H; Lee D; Larsson O; McLaughlan S; Topisirovic I; Wang Z; Wang Z; Zhao Y; Wildes D; Aggen JB; Singh M; Gill AL; Smith JAM; Rosen N
Article: NATURE COMMUNICATIONS. 2021;12(1):4651
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
Ghaddar N; Wang S; Woodvine B; Krishnamoorthy J; van Hoef V; Darini C; Kazimierczak U; Ah-son N; Popper H; Johnson M; Officer L; Teodosio A; Broggini M; Mann KK; Hatzoglou M; Topisirovic I; Larsson O; Le Quesne J; Koromilas AE
Article: SCIENCE ADVANCES. 2021;7(22):eabf0971
Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR
Kaspar S; Oertlin C; Szczepanowska K; Kukat A; Senft K; Lucas C; Brodesser S; Hatzoglou M; Larsson O; Topisirovic I; Trifunovic A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(44):27556-27565
MNK2 governs the macrophage antiinflammatory phenotype
Bartish M; Tong D; Pan Y; Wallerius M; Liu H; Ristau J; Ferreira SDS; Wallmann T; van Hoef V; Masvidal L; Kerzel T; Joly A-L; Goncalves C; Preston SEJ; Ebrahimian T; Seitz C; Bergh J; Pietras K; Lehoux S; Naldini L; Andersson J; Squadrito ML; del RSV; Larsson O; Rolny C
Article: EMBO JOURNAL. 2020;39(21):e105111
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis
Kusnadi EP; Trigos AS; Cullinane C; Goode DL; Larsson O; Devlin JR; Chan KT; De Souza DP; McConville MJ; McArthur GA; Thomas G; Sanij E; Poortinga G; Hannan RD; Hannan KM; Kang J; Pearson RB
Article: MOLECULAR CANCER RESEARCH. 2020;18(10):1560-1573
SPANX Control of Lamin A/C Modulates Nuclear Architecture and Promotes Melanoma Growth
Lazar I; Fabre B; Feng Y; Khateb A; Turko P; Gomez JMM; Frederick DT; Levesque MP; Feld L; Zhang G; Zhang T; James B; Shklover J; Avitan-Hersh E; Livneh I; Scortegagna M; Brown K; Larsson O; Topisirovic I; Wolfenson H; Herlyn M; Flaherty K; Dummer R; Ronai ZA
Article: PLOS PATHOGENS. 2020;16(6):e1008291
Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts
Chaparro V; Leroux L-P; Masvidal L; Lorent J; Graber TE; Zimmermann A; Duque GA; Descoteaux A; Alain T; Larsson O; Jaramillo M
Article: EMBO JOURNAL. 2019;38(23):e101323
Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression
Lorent J; Kusnadi EP; van Hoef V; Rebello RJ; Leibovitch M; Ristau J; Chen S; Lawrence MG; Szkop KJ; Samreen B; Balanathan P; Rapino F; Close P; Bukczynska P; Scharmann K; Takizawa I; Risbridger GP; Selth LA; Leidel SA; Lin Q; Topisirovic I; Larsson O; Furic L
Article: PLOS BIOLOGY. 2019;17(12):e3000535
Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation
Hipolito VEB; Diaz JA; Tandoc KV; Oertlin C; Ristau J; Chauhan N; Saric A; Mclaughlan S; Larsson O; Topisirovic I; Botelho RJ
Article: NEURON. 2019;104(4):665-679.e8
Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response
Johnson JL; Stoica L; Liu Y; Zhu PJ; Bhattacharya A; Buffington SA; Huq R; Eissa NT; Larsson O; Porse BT; Domingo D; Nawaz U; Carroll R; Jolly L; Scerri TS; Kim H-G; Brignell A; Coleman MJ; Braden R; Kini U; Jackson V; Baxter A; Bahlo M; Scheffer IE; Amor DJ; Hildebrand MS; Bonnen PE; Beeton C; Gecz J; Morgan AT; Costa-Mattioli M
Article: NATURE COMMUNICATIONS. 2019;10(1):5151
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
Chan K; Robert F; Oertlin C; Kapeller-Libermann D; Avizonis D; Gutierrez J; Handly-Santana A; Doubrovin M; Park J; Schoepfer C; Da Silva B; Yao M; Gorton F; Shi J; Thomas CJ; Brown LE; Porco JAJ; Pollak M; Larsson O; Pelletier J; Chio IIC
Article: CELL DEATH AND DISEASE. 2019;10(11):845
RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity
Ristau J; van Hoef V; Peuget S; Zhu J; Guan B-J; Liang S; Hatzoglou M; Topisirovic I; Selivanova G; Larsson O
Article: JCI INSIGHT. 2019;4(21):121951
eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss i n pancreatic cancer
Muller D; Shin S; de Rugy TG; Samain R; Baer R; Strehaiano M; Masvidal-Sanz L; Guillermet-Guibert J; Jean C; Tsukumo Y; Sonenberg N; Marion F; Guilbaud N; Hoffmann J-S; Larsson O; Bousquet C; Pyronnet S; Martineau Y
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2019;200(3):348-358
Distinct Cancer-Promoting Stromal Gene Expression Depending on Lung Function
Sandri BJ; Masvidal L; Murie C; Bartish M; Avdulov S; Higgins L; Markowski T; Peterson M; Bergh J; Yang P; Rolny C; Limper AH; Griffin TJ; Bitterman PB; Wendt CH; Larsson O
Article: NUCLEIC ACIDS RESEARCH (NAR). 2019;47(12):e70
Generally applicable transcriptome-wide analysis of translation using anota2seq
Oertlin C; Lorent J; Murie C; Furic L; Topisirovic I; Larsson O
Article: NATURE COMMUNICATIONS. 2019;10(1):2901
An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
Smith HW; Smith HW; Hirukawa A; Sanguin-Gendreau V; Nandi I; Dufour CR; Zuo D; Tandoc K; Leibovitch M; Singh S; Rennhack JP; Swiatnicki M; Lavoie C; Papavasiliou V; Temps C; Carragher NO; Unciti-Broceta A; Savage P; Basik M; van Hoef V; Larsson O; Cooper CL; Calderon ACV; Beith J; Millar E; Selinger C; Giguere V; Park M; Harris LN; Varadan V; Andrechek ER; O'Toole SA; Topisirovic I; Muller WJ
Article: PLOS PATHOGENS. 2019;15(6):e1007842
Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery
Gotte B; Panas MD; Hellstrom K; Liu L; Samreen B; Larsson O; Ahola T; McInerney GM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(16):7973-7981
Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis
Morita M; Siddiqui N; Katsumura S; Rouya C; Larsson O; Nagashima T; Hekrnatnejad B; Takahashi A; Kiyonari H; Zang M; St-Arnaud R; Oike Y; Giguere V; Tcpisirovic I; Okada-Hatakeyama M; Yamamoto T; Sonenberg N
Article: CELL METABOLISM. 2018;28(6):817-832.e8
Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
Hulea L; Gravel S-P; Morita M; Cargnello M; Uchenunu O; Im YK; Lehuede C; Ma EH; Leibovitch M; McLaughlan S; Blouin M-J; Parisotto M; Papavasiliou V; Lavoie C; Larsson O; Ohh M; Ferreira T; Greenwood C; Bridon G; Avizonis D; Ferbeyre G; Siegel P; Jones RG; Muller W; Ursini-Siegel J; St-Pierre J; Pollak M; Topisirovic I
Article: NUCLEIC ACIDS RESEARCH (NAR). 2018;46(15):7772-7792
A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease
Timmons JA; Atherton PJ; Larsson O; Sood S; Blokhin IO; Brogan RJ; Volmar C-H; Josse AR; Slentz C; Wahlestedt C; Phillips SM; Phillips BE; Gallagher IJ; Kraus WE
Article: INFECTION AND IMMUNITY. 2018;86(9):e00244-e00218
The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome
Leroux L-P; Lorent J; Graber TE; Chaparro V; Masvidal L; Aguirre M; Fonseca BD; van Kempen LC; Alain T; Larsson O; Jaramillo M
Article: JOURNAL OF IMMUNOLOGY. 2018;200(12):4102-4116
eIF4E-Binding Proteins 1 and 2 Limit Macrophage Anti-Inflammatory Responses through Translational Repression of IL-10 and Cyclooxygenase-2
William M; Leroux L-P; Chaparro V; Lorent J; Graber TE; M'Boutchou M-N; Charpentier T; Fabie A; Dozois CM; Stager S; van Kempen LC; Alain T; Larsson O; Jaramillo M
Article: NUCLEIC ACIDS RESEARCH (NAR). 2018;46(1):e3
Polysome-profiling in small tissue samples
Liang S; Bellato HM; Lorent J; Lupinacci FCS; Oertlin C; van Hoef V; Andrade VP; Roffe M; Masvidal L; Hajj GNM; Larsson O
Article: ADVANCES IN BIOLOGICAL REGULATION. 2018;67:128-133
Normalization of mass spectrometry data (NOMAD).
Murie C; Sandri B; Sandberg A-S; Griffin TJ; Lehtiö J; Wendt C; Larsson O
Article: MOLECULAR CELL. 2017;68(5):885-900.e6
A Unique ISR Program Determines Cellular Responses to Chronic Stress
Guan B-J; van Hoef V; Jobava R; Elroy-Stein O; Valasek LS; Cargnello M; Gao X-H; Krokowski D; Merrick WC; Kimball SR; Komar AA; Koromilas AE; Wynshaw-Boris A; Topisirovic I; Larsson O; Hatzoglou M
Article: RNA BIOLOGY. 2017;14(10):1299-1305
mTOR-sensitive translation: Cleared fog reveals more trees
Masvidal L; Hulea L; Furic L; Topisirovic I; Larsson O
Article: MOLECULAR CELL. 2017;67(6):922-935.e5
mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1
Morita M; Prudent J; Basu K; Goyon V; Katsumura S; Hulea L; Pearl D; Siddiqui N; Strack S; McGuirk S; St-Pierre J; Larsson O; Topisirovic I; Vali H; McBride HM; Bergeron JJ; Sonenberg N
Article: ONCOGENE. 2016;35(39):5093-5105
Tumor cell survival dependence on the DHX9 DExH-box helicase
Lee T; Paquet M; Larsson O; Pelletier J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(38):E5618-E5627
Pericyte-fibroblast transition promotes tumor growth and metastasis
Hosaka K; Yang Y; Seki T; Fischer C; Dubey O; Fredlund E; Hartman J; Religa P; Morikawa H; Ishii Y; Sasahara M; Larsson O; Cossu G; Cao R; Lim S; Cao Y
Article: BLOOD. 2016;128(11):1475-1489
IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells
Mao Y; van Hoef V; Zhang X; Wennerberg E; Lorent J; Witt K; Masvidal L; Liang S; Murray S; Larsson O; Kiessling R; Lundqvist A
Article: NUCLEIC ACIDS RESEARCH (NAR). 2016;44(11):e109
iGEMS: an integrated model for identification of alternative exon usage events
Sood S; Szkop KJ; Nakhuda A; Gallagher IJ; Murie C; Brogan RJ; Kaprio J; Kainulainen H; Atherton PJ; Kujala UM; Gustafsson T; Larsson O; Timmons JA
Article: GENOME RESEARCH. 2016;26(5):636-648
nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs
Gandin V; Masvidal L; Hulea L; Gravel S-P; Cargnello M; McLaughlan S; Cai Y; Balanathan P; Morita M; Rajakumar A; Furic L; Pollak M; Porco JAJ; St-Pierre J; Pelletier J; Larsson O; Topisirovic I
Article: NATURE COMMUNICATIONS. 2016;7:11127
mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
Gandin V; Masvidal L; Cargnello M; Gyenis L; McLaughlan S; Cai Y; Tenkerian C; Morita M; Balanathan P; Jean-Jean O; Stambolic V; Trost M; Furic L; Larose L; Koromilas AE; Asano K; Litchfield D; Larsson O; Topisirovic I
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2015;308(12):E1085-E1105
A stringent validation of mouse adipose tissue identity markers
de Jong JMA; Larsson O; Cannon B; Nedergaard J
Article: ONCOGENE. 2015;34(16):2032-2042
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
Robichaud N; del Rincon SV; Huor B; Alain T; Petruccelli LA; Hearnden J; Goncalves C; Grotegut S; Spruck CH; Furic L; Larsson O; Muller WJ; Miller WH; Sonenberg N
Article: CELL CYCLE. 2015;14(4):473-480
mTOR coordinates protein synthesis, mitochondrial activity and proliferation
Morita M; Gravel S-P; Hulea L; Larsson O; Pollak M; St-Pierre J; Topisirovic I
Article: ONCOTARGET. 2015;6(2):604-616
Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity
Takizawa I; Lawrence MG; Balanathan P; Rebello R; Pearson HB; Garg E; Pedersen J; Pouliot N; Nadon R; Watt MJ; Taylor RA; Humbert P; Topisirovic I; Larsson O; Risbridger GP; Furic L
Article: PLOS ONE. 2015;10(7):e0133482
Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes
Livingstone M; Sikstrom K; Robert PA; Uze G; Larsson O; Pellegrini S
Article: JOURNAL OF PATHOLOGY. 2014;234(1):86-98
A pro-tumourigenic loop at the human prostate tumour interface orchestrated by oestrogen, CXCL12 and mast cell recruitment
Ellem SJ; Taylor RA; Furic L; Larsson O; Frydenberg M; Pook D; Pedersen J; Cawsey B; Trotta A; Need E; Buchanan G; Risbridger GP
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(33):22798-22814
Suppression of the DHX9 Helicase Induces Premature Senescence in Human Diploid Fibroblasts in a p53-dependent Manner
Lee T; Di Paola D; Malina A; Mills JR; Kreps A; Grosse F; Tang H; Zannis-Hadjopoulos M; Larsson O; Pelletier J
Article: JOURNAL OF MOLECULAR CELL BIOLOGY. 2014;6(3):255-266
Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner
Miloslavski R; Cohen E; Avraham A; Iluz Y; Hayouka Z; Kasir J; Mudhasani R; Jones SN; Cybulski N; Rueegg MA; Larsson O; Gandin V; Rajakumar A; Topisirovic I; Meyuhas O
Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2014;(87):51455
Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
Gandin V; Sikstrom K; Alain T; Morita M; McLaughlan S; Larsson O; Topisirovic I
Article: JOURNAL OF THORACIC ONCOLOGY. 2014;9(5):639-645
Correlation of Regional Emphysema and Lung Cancer A Lung Tissue Research Consortium-Based Study
Hohberger LA; Schroeder DR; Bartholmai BJ; Yang P; Wendt CH; Bitterman PB; Larsson O; Limper AH
Article: AMERICAN JOURNAL OF PATHOLOGY. 2014;184(5):1369-1383
Identification of a Cell-of-Origin for Fibroblasts Comprising the Fibrotic Reticulum in Idiopathic Pulmonary Fibrosis
Xia H; Bodempudi V; Benyumov A; Hergert P; Tank D; Herrera J; Braziunas J; Larsson O; Parker M; Rossi D; Smith K; Peterson M; Limper A; Jessurun J; Connett J; Ingbar D; Sem P; Bitterman PB; Henke CA
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(4):1622-1635
Fibrotic extracellular matrix activates a profibrotic positive feedback loop
Parker MW; Rossi D; Peterson M; Smith K; Sikstrom K; White ES; Connett JE; Henke CA; Larsson O; Bitterman PB
Article: PROSTATE. 2013;73(16):1810-1823
Hedgehog Signaling Is Active in Human Prostate Cancer Stroma and Regulates Proliferation and Differentiation of Adjacent Epithelium
Wilkinson SE; Furic L; Buchanan G; Larsson O; Pedersen J; Frydenberg M; Risbridger GP; Taylor RA
Article: CELL METABOLISM. 2013;18(5):698-711
mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
Morita M; Gravel S-P; Chenard V; Sikstrom K; Zheng L; Alain T; Gandin V; Avizonis D; Arguello M; Zakaria C; McLaughlan S; Nouet Y; Pause A; Pollak M; Gottlieb E; Larsson O; St-Pierre J; Topisirovic I; Sonenberg N
Article: PLOS GENETICS. 2013;9(5):e1003494
Distinct Translational Control in CD4⁺ T Cell Subsets
Bjur E; Larsson O; Yurchenko E; Zheng L; Gandin V; Topisirovic I; Li S; Wagner CR; Sonenberg N; Piccirillo CA
Article: BLOOD. 2013;121(17):3402-3412
RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model
Mills JR; Malina A; Lee T; Di Paola D; Larsson O; Miething C; Grosse F; Tang H; Zannis-Hadjopoulos M; Lowe SW; Pelletier J
Article: TRANSLATION. 2013;1(1):e24557
Re-analysis of genome wide data on mammalian microRNA-mediated suppression of gene expression.
Larsson O; Nadon R
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2013;5(1):a012302
Toward a Genome-Wide Landscape of Translational Control
Larsson O; Tian B; Sonenberg N
Article: NATURE COMMUNICATIONS. 2013;4:2129
Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis
Hosaka K; Yang Y; Seki T; Nakamura M; Andersson P; Rouhi P; Yang X; Jensen L; Lim S; Feng N; Xue Y; Li X; Larsson O; Ohhashi T; Cao Y
Article: MOLECULAR AND CELLULAR BIOLOGY. 2012;32(17):3585-3593
A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development
Morita M; Ler LW; Fabian MR; Siddiqui N; Mullin M; Henderson VC; Alain T; Fonseca BD; Karashchuk G; Bennett CF; Kabuta T; Higashi S; Larsson O; Topisirovic I; Smith RJ; Gingras A-C; Sonenberg N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(24):9551-9556
Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors
Edlund K; Larsson O; Ameur A; Bunikis I; Gyllensten U; Leroy B; Sundstrom M; Micke P; Botling J; Soussi T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(23):8977-8982
Distinct perturbation of the translatome by the antidiabetic drug metformin
Larsson O; Morita M; Topisirovic I; Alain T; Blouin M-J; Pollak M; Sonenberg N
Article: NATURE MEDICINE. 2011;18(1):100-110
PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
Xue Y; Lim S; Yang Y; Wang Z; Jensen LDE; Hedlund E-M; Andersson P; Sasahara M; Larsson O; Galter D; Gao R; Hosaka K; Cao Y
Article: BIOINFORMATICS. 2011;27(10):1440-1441
anota: analysis of differential translation in genome-wide studies
Larsson O; Sonenberg N; Nadon R
Article: CELL HOST AND MICROBE. 2011;9(4):331-341
Leishmania Repression of Host Translation through mTOR Cleavage Is Required for Parasite Survival and Infection
Jaramillo M; Gomez MA; Larsson O; Shio MT; Topisirovic I; Contreras I; Luxenburg R; Rosenfeld A; Colina R; McMaster RW; Olivier M; Costa-Mattioli M; Sonenberg N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(50):21487-21492
Identification of differential translation in genome wide studies
Larsson O; Sonenberg N; Nadon R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(32):14134-14139
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
Furic L; Rong L; Larsson O; Koumakpayi IH; Yoshida K; Brueschke A; Petroulakis E; Robichaud N; Pollak M; Gaboury LA; Pandolfi PP; Saad F; Sonenberg N
Article: SCIENCE. 2010;328(5982):1172-1176
mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs
Dowling RJO; Topisirovic I; Alain T; Bidinosti M; Fonseca BD; Petroulakis E; Wang X; Larsson O; Selvaraj A; Liu Y; Kozma SC; Thomas G; Sonenberg N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(52):22217-22222
The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis
Parsyan A; Shahbazian D; Martineau Y; Petroulakis E; Alain T; Larsson O; Mathonnet G; Tettweiler G; Hellen CU; Pestova TV; Svitkin YV; Sonenberg N
Article: CHEMISTRY AND BIOLOGY. 2009;16(12):1240-1249
A Chemical Genetic Screen for mTOR Pathway Inhibitors Based on 4E-BP-Dependent Nuclear Accumulation of eIF4E
Livingstone M; Larsson O; Sukarieh R; Pelletier J; Sonenberg N
Article: CANCER CELL. 2009;16(5):439-446
p53-Dependent Translational Control of Senescence and Transformation via 4E-BPs
Petroulakis E; Parsyan A; Dowling RJO; LeBacquer O; Martineau Y; Bidinosti M; Larsson O; Alain T; Rong L; Mamane Y; Paquet M; Furic L; Topisirovic I; Shahbazian D; Livingstone M; Costa-Mattioli M; Teodoro JG; Sonenberg N
Article: CANCER RESEARCH. 2009;69(21):8455-8462
Eukaryotic Initiation Factor 4E Binding Protein Family of Proteins: Sentinels at a Translational Control Checkpoint in Lung Tumor Defense
Kim YY; Von Weymarn L; Larsson O; Fan D; Underwood JM; Peterson MS; Hecht SS; Polunovsky VA; Bitterman PB
Article: RNA: A PUBLICATION OF THE RNA SOCIETY. 2009;15(8):1469-1482
Regulatory element identification in subsets of transcripts: Comparison and integration of current computational methods
Fan D; Bitterman PB; Larsson O
Article: CELL METABOLISM. 2009;9(1):99-109
Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation
Xue Y; Petrovic N; Cao R; Larsson O; Lim S; Chen S; Feldmann HM; Liang Z; Zhu Z; Nedergaard J; Cannon B; Cao Y
Article: PROSTATE. 2009;69(1):33-40
Insulin Receptor Expression by Human Prostate Cancers
Cox ME; Gleave ME; Zakikhani M; Bell RH; Piura E; Vickers E; Cunningham M; Larsson O; Fazli L; Pollak M
Article: PLOS ONE. 2009;4(3):e4868
Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E-A Computational Inference
Santhanam AN; Bindewald E; Rajasekhar VK; Larsson O; Sonenberg N; Colburn NH; Shapiro BA
Article: PLOS ONE. 2008;3(9):e3220
Fibrotic Myofibroblasts Manifest Genome-Wide Derangements of Translational Control
Larsson O; Diebold D; Fan D; Peterson M; Nho RS; Bitterman PB; Henke CA
Article: NATURE. 2008;452(7185):323-328
Translational control of the innate immune response through IRF-7
Colina R; Costa-Mattioli M; Dowling RJO; Jaramillo M; Tai L-H; Breitbach CJ; Martineau Y; Larsson O; Rong L; Svitkin YV; Makrigiannis AP; Bell JC; Sonenberg N
Article: MOLECULAR CELL. 2008;29(2):263-270
Conserved GU-rich elements mediate mRNA decay by binding to CUG-binding protein 1
Vlasova IA; Tahoe NM; Fan D; Larsson O; Rattenbacher B; John JRS; Vasdewani J; Karypis G; Reilly CS; Bitterman PB; Bohjanen PR
Article: THE FASEB JOURNAL. 2007;21(13):3653-3665
Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?
Scheele C; Nielsen AR; Walden TB; Sewell DA; Fischer CP; Brogan RJ; Petrovic N; Larsson O; Tesch PA; Wennmalm K; Hutchinson DS; Cannon B; Wahlestedt C; Pedersen BK; Timmons JA
Article: CANCER RESEARCH. 2007;67(14):6814-6824
Eukaryotic translation initiation factor 4E-Induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors
Larsson O; Li S; Issaenko OA; Avdulov S; Peterson M; Smith K; Bitterman PB; Polunovsky VA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(11):4401-4406
Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
Timmons JA; Wennmalm K; Larsson O; Walden TB; Lassmann T; Petrovic N; Hamilton DL; Gimeno RE; Wahlestedt C; Baar K; Nedergaard J; Cannon B
Article: PLOS ONE. 2007;2(2):e242
Epigenetic Activation of a Subset of mRNAs by eIF4E Explains Its Effects on Cell Proliferation
Mamane Y; Petroulakis E; Martineau Y; Sato T-A; Larsson O; Rajasekhar VK; Sonenberg N
Article: BMC BIOINFORMATICS. 2007;8:48
Improved precision and accuracy for microarrays using updated probe set definitions
Sandberg R; Larsson O
Article: NUCLEIC ACIDS RESEARCH (NAR). 2006;34(16):4375-4386
Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure
Larsson O; Perlman DM; Fan D; Reilly CS; Peterson M; Dahlgren C; Liang Z; Li S; Polunovsky VA; Wahlestedt C; Bitterman PB
Article: OMICS A JOURNAL OF INTEGRATIVE BIOLOGY. 2006;10(3):381-397
Comparative microarray analysis
Larsson O; Wennmalm K; Sandberg R
Article: THE FASEB JOURNAL. 2005;19(7):750-760
Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy
Timmons JA; Larsson O; Jansson E; Fischer H; Gustafsson T; Greenhaff PL; Ridden P; Rachman J; Peyrard-Janvid M; Wahlestedt C; Sundberg CJ
Article: GENOME BIOLOGY. 2005;6(13):R109
The expression signature of in vitro senescence resembles mouse but not human aging
Wennmalm K; Wahlestedt C; Larsson O
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;316(3):680-687
Functional comparison of single- and double-stranded siRNAs in mammalian cells
Xu YH; Linde A; Larsson A; Thormeyer D; Elmen J; Wahlestedt C; Liang ZC
Article: CANCER RESEARCH. 2004;64(2):482-489
Kinetics of senescence-associated changes of gene expression in an epithelial, temperature-sensitive SV40 large T antigen model
Larsson O; Scheele C; Liang ZC; Moll J; Karlsson C; Wahlestedt C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;306(3):712-717
Effective small interfering RNAs and phosphorothioate antisense DNAs have different preferences for target sites in the luciferase mRNAs
Xu YH; Zhang HY; Thormeyer D; Larsson A; Du Q; Elmén J; Wahlestedt C; Liang Z
Article: BIOTECHNIQUES. 2003;34(2):346-355
Characterization of lacZ complementation deletions using membrane receptor dimerization
Thormeyer D; Ammerpohl O; Larsson O; Xu Y; Asinger A; Wahlestedt C; Liang Z
Article: NUCLEIC ACIDS RESEARCH (NAR). 2002;30(23):e133
Quantitative codon optimisation of DNA libraries encoding sub-random peptides:: design and characterisation of a novel library encoding transmembrane domain peptides -: art. no. e133
Larsson O; Thormeyer D; Asinger A; Wihlén B; Wahlestedt C; Liang Z
Article: NATURE BIOTECHNOLOGY. 2001;19(4):360-364
Bactericidal antisense effects of peptide-PNA conjugates
Good L; Awasthi SK; Dryselius R; Larsson O; Nielsen PE
Article: MICROBIOLOGY (UNITED KINGDOM). 2000;146:2665-2670
Antisense PNA effects in Escherichia coli are limited by the outer-membrane LPS layer
Good L; Sandberg R; Larsson O; Nielsen PE; Wahlestedt C
Article: NUCLEIC ACIDS RESEARCH (NAR). 2000;28(14):E71
Silanized nucleic acids: a general platform for DNA immobilization.
Kumar A; Larsson O; Parodi D; Liang Z
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Preprint: BIORXIV. 2023
Epigenetic coordination of transcriptional and translational programs in hypoxia
Watt K; Dauber B; Szkop K; Lee L; Jovanovic P; Chen S; Masvidal L; Tandoc K; Palia R; Topisirovic I; Larsson O; Postovit L-M
Review: NATURE REVIEWS CANCER. 2023;23(6):408-425
The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment
Bartish M; Abraham MJ; Goncalves C; Larsson O; Rolny C; Del Rincon SV
Preprint: RES SQ. 2023;RES SQ
Translatome analysis of Tuberous Sclerosis Complex-1 patient-derived neural progenitor cells reveal rapamycin-dependent and independent alterations.
Aksoylu IS; Martin P; Robert F; Szkop KJ; Redmond NE; Chen S; Beauchamp RL; Nobeli I; Pelletier J; Larsson O; Ramesh V
Preprint: BIORXIV. 2023
Amino acid usage and tRNA expression underlies proteome adaptation inPlasmodium falciparum
Li Q; Vetter L; Veith Y; Christ E; Végvári Á; Sahin C; Ribacke U; Wahlgren M; Ankarklev J; Larsson O; Chan SC-L
Review: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH. 2022;1869(1):119140
Regulation of gene expression via translational buffering
Kusnadi EP; Timpone C; Topisirovic I; Larsson O; Furic L
Corrigendum: NATURE CHEMICAL BIOLOGY. 2021;17(11):1209
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth (vol 17, pg 1065, 2021)
Lee BJ; Boyer JA; Burnett GL; Thottumkara AP; Tibrewal N; Wilson SL; Hsieh T; Marquez A; Lorenzana EG; Evans JW; Hulea L; Kiss G; Liu H; Lee D; Larsson O; McLaughlan S; Topisirovic I; Wang Z; Wang Z; Zhao Y; Wildes D; Aggen JB; Singh M; Gill AL; Smith JAM; Rosen N
Preprint: BIORXIV. 2021
Regulatory start-stop elements in 5’ untranslated regions pervasively modulate translation
Rendleman J; Haizel S; Wu S; Liu J; Ge X; Zou H; Mohammad MP; Pressler M; Maity S; Hronová V; Gao Z; Herrmannová A; Lei A; Allgoewer K; Sultanov D; Hinckley WE; Cheng Z; Shelby L; Szkop K; Topisirovic I; Larsson O; Hatzoglou M; Valášek LS; Vogel C
Conference publication: EUROPEAN JOURNAL OF CANCER. 2020;138:S23
The integrated stress response exposes a therapeutic vulnerability in KRAS driven lung cancer
Ghaddar N; Wang S; Woodvine B; Krishnamoorthy J; Darini C; Van Hoef V; Popper H; Topisirovic I; Larsson O; Le Quesne J; Koromilas A
Review: BIOCHIMICA ET BIOPHYSICA ACTA - REVIEWS ON CANCER. 2017;1868(2):484-499
Cancer as an ecomolecular disease and a neoplastic consortium
Ramon y Cajal S; Capdevila C; Hernandez-Losa J; De Mattos-Arruda L; Ghosh A; Lorent J; Larsson O; Aasen T; Postovit L-M; Topisirovic I
Review: NATURE IMMUNOLOGY. 2014;15(6):503-511
Translational control of immune responses: from transcripts to translatomes
Piccirillo CA; Bjur E; Topisirovic I; Sonenberg N; Larsson O
Review: METHODS IN ENZYMOLOGY. 2009;457:211-229
USING FUNCTIONAL GENOMICS TO STUDY PINK1 AND METABOLIC PHYSIOLOGY
Scheele C; Larsson O; Timmons JA
Review: BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS. 2008;25:77-92
Gene Expression - Time to Change Point of View?
Larsson O; Nadon R
Letter: NATURE BIOTECHNOLOGY. 2006;24(11):1322-1323
Lack of correct data format and comparability limits future integrative microarray research
Larsson O; Sandberg R
Letter: BMC BIOINFORMATICS. 2005;6:129
Considerations when using the significance analysis of microarrays (SAM) algorithm
Larsson O; Wahlestedt C; Timmons JA
Thesis / dissertation: 2005
Transcriptome studies of cell-fate and aging
Larsson, Ola
Review: TOPICS IN CURRENT CHEMISTRY. 2005;261:45-61
DNA immobilization: Silanized nucleic acids and nanoprinting
Du Q; Larsson O; Swerdlow H; Liang Z

Forskningsbidrag

Translational Control In Plasmodiuim falciparum
Swedish Research Council
1 January 2022 - 31 December 2025
Examining the MNK1/2-eIF4E axis in cancer associated fibroblasts as a driver of oncogenic progression
Canadian Cancer Society
1 May 2021 - 30 April 2026
Targeting mRNA translation to reverse resistance to endocrine therapy
Swedish Research Council
1 December 2020 - 31 December 2022
Targeting mRNA translation to reverse resistance to endocrine therapy
Swedish Cancer Society
1 January 2019
Codon bias: a hidden layer of translational regulation by estrogens
National Health and Medical Research Council
1 January 2018 - 31 December 2020
Mechanistic dissection of the eIF4F complex in breast cancer
Swedish Research Council
1 January 2017 - 31 December 2020
Identification of mechanisms facilitating oncogenic mRNA translation
Swedish Research Council
1 January 2014 - 31 December 2016
Utredning av betydelsen för translationell kontroll av genuttryck i bröstcancer
Swedish Research Council
1 January 2010 - 31 December 2013
Utredning av betydelsen för translationell kontroll av genuttryck i bröstcancer
Swedish Research Council
1 January 2010 - 31 December 2013

Anställningar

Senior Forskare, Onkologi-Patologi, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Experimentell onkologi, Karolinska Institutet, 2016
MEDICINE DOKTORSEXAMEN, CENTRUM FÖR GENOMFORSKNING (C9), Karolinska Institutet, 2005
Medicine Magisterexamen, Karolinska Institutet, 2000

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Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

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