Ola Larsson

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: MOLECULAR AUTISM. 2023;14(1):39

Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations

Aksoylu IS; Martin P; Robert F; Szkop KJ; Redmond NE; Bhattacharyya S; Wang J; Chen S; Beauchamp RL; Nobeli I; Pelletier J; Larsson O; Ramesh V
Article: SCIENCE ADVANCES. 2023;9(30):eadg1805

Control of protein synthesis through mRNA pseudouridylation by dyskerin

Pederiva C; Trevisan DM; Peirasmaki D; Chen S; Savage SA; Larsson O; Ule J; Baranello L; Agostini F; Farnebo M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2023;654:73-79

An extracellular matrix stiffness-induced breast cancer cell transcriptome resembles the transition from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC)

Goransson S; Chen S; Olofsson H; Larsson O; Stromblad S
Article: NATURE CHEMICAL BIOLOGY. 2022;18(9):942-953

MNK2 deficiency potentiates β-cell regeneration via translational regulation

Karampelias C; Watt K; Mattsson CL; Ruiz AF; Rezanejad H; Mi J; Liu X; Chu L; Locasale JW; Korbutt GS; Rovira M; Larsson O; Andersson O
Article: CELL REPORTS. 2022;40(3):111092

Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR

Krokowski D; Jobava R; Szkop KJ; Chen C-W; Fu X; Venus S; Guan B-J; Wu J; Gao Z; Banaszuk W; Tchorzewski M; Mu T; Ropelewski P; Merrick WC; Mao Y; Sevval AI; Miranda H; Qian S-B; Manifava M; Ktistakis NT; Vourekas A; Jankowsky E; Topisirovic I; Larsson O; Hatzoglou M
Article: CELL METABOLISM. 2022;34(4):564-580.e8

Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure

Katsumura S; Siddiqui N; Goldsmith MR; Cheah JH; Fujikawa T; Minegishi G; Yamagata A; Yabuki Y; Kobayashi K; Shirouzu M; Inagaki T; Huang TH-M; Musi N; Topisirovic I; Larsson O; Morita M
Article: EMBO JOURNAL. 2022;41(6):e108650

PABP prevents the untimely decay of select mRNA populations in human cells

Kajjo S; Sharma S; Chen S; Brothers WR; Cott M; Hasaj B; Jovanovic P; Larsson O; Fabian MR
Article: NATURE COMMUNICATIONS. 2022;13(1):1100

Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF^V600 melanoma

Smith LK; Parmenter T; Kleinschmidt M; Kusnadi EP; Kang J; Martin CA; Lau P; Patel R; Lorent J; Papadopoli D; Trigos A; Ward T; Rao AD; Lelliott EJ; Sheppard KE; Goode D; Hicks RJ; Tiganis T; Simpson KJ; Larsson O; Blythe B; Cullinane C; Wickramasinghe VO; Pearson RB; McArthur GA
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:243-268

Anota2seq Analysis for Transcriptome-Wide Studies of mRNA Translation.

Oertlin C; Watt K; Ristau J; Larsson O
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:223-241

Polysome Fractionation for Transcriptome-Wide Studies of mRNA Translation.

Ristau J; Watt K; Oertlin C; Larsson O
Article: NATURE CHEMICAL BIOLOGY. 2021;17(10):1065-1074

Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth

Lee BJ; Boyer JA; Burnett GL; Thottumkara AP; Tibrewal N; Wilson SL; Hsieh T; Marquez A; Lorenzana EG; Evans JW; Hulea L; Kiss G; Liu H; Lee D; Larsson O; McLaughlan S; Topisirovic I; Wang Z; Wang Z; Zhao Y; Wildes D; Aggen JB; Singh M; Gill AL; Smith JAM; Rosen N
Article: NATURE COMMUNICATIONS. 2021;12(1):4651

The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer

Ghaddar N; Wang S; Woodvine B; Krishnamoorthy J; van Hoef V; Darini C; Kazimierczak U; Ah-son N; Popper H; Johnson M; Officer L; Teodosio A; Broggini M; Mann KK; Hatzoglou M; Topisirovic I; Larsson O; Le Quesne J; Koromilas AE
Article: SCIENCE ADVANCES. 2021;7(22):eabf0971

Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR

Kaspar S; Oertlin C; Szczepanowska K; Kukat A; Senft K; Lucas C; Brodesser S; Hatzoglou M; Larsson O; Topisirovic I; Trifunovic A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(44):27556-27565

MNK2 governs the macrophage antiinflammatory phenotype

Bartish M; Tong D; Pan Y; Wallerius M; Liu H; Ristau J; Ferreira SDS; Wallmann T; van Hoef V; Masvidal L; Kerzel T; Joly A-L; Goncalves C; Preston SEJ; Ebrahimian T; Seitz C; Bergh J; Pietras K; Lehoux S; Naldini L; Andersson J; Squadrito ML; del RSV; Larsson O; Rolny C
Article: EMBO JOURNAL. 2020;39(21):e105111

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

Kusnadi EP; Trigos AS; Cullinane C; Goode DL; Larsson O; Devlin JR; Chan KT; De Souza DP; McConville MJ; McArthur GA; Thomas G; Sanij E; Poortinga G; Hannan RD; Hannan KM; Kang J; Pearson RB
Article: MOLECULAR CANCER RESEARCH. 2020;18(10):1560-1573

SPANX Control of Lamin A/C Modulates Nuclear Architecture and Promotes Melanoma Growth

Lazar I; Fabre B; Feng Y; Khateb A; Turko P; Gomez JMM; Frederick DT; Levesque MP; Feld L; Zhang G; Zhang T; James B; Shklover J; Avitan-Hersh E; Livneh I; Scortegagna M; Brown K; Larsson O; Topisirovic I; Wolfenson H; Herlyn M; Flaherty K; Dummer R; Ronai ZA
Article: PLOS PATHOGENS. 2020;16(6):e1008291

Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts

Chaparro V; Leroux L-P; Masvidal L; Lorent J; Graber TE; Zimmermann A; Duque GA; Descoteaux A; Alain T; Larsson O; Jaramillo M
Article: EMBO JOURNAL. 2019;38(23):e101323

Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression

Lorent J; Kusnadi EP; van Hoef V; Rebello RJ; Leibovitch M; Ristau J; Chen S; Lawrence MG; Szkop KJ; Samreen B; Balanathan P; Rapino F; Close P; Bukczynska P; Scharmann K; Takizawa I; Risbridger GP; Selth LA; Leidel SA; Lin Q; Topisirovic I; Larsson O; Furic L
Article: PLOS BIOLOGY. 2019;17(12):e3000535

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation

Hipolito VEB; Diaz JA; Tandoc KV; Oertlin C; Ristau J; Chauhan N; Saric A; Mclaughlan S; Larsson O; Topisirovic I; Botelho RJ
Article: NEURON. 2019;104(4):665-679.e8

Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

Johnson JL; Stoica L; Liu Y; Zhu PJ; Bhattacharya A; Buffington SA; Huq R; Eissa NT; Larsson O; Porse BT; Domingo D; Nawaz U; Carroll R; Jolly L; Scerri TS; Kim H-G; Brignell A; Coleman MJ; Braden R; Kini U; Jackson V; Baxter A; Bahlo M; Scheffer IE; Amor DJ; Hildebrand MS; Bonnen PE; Beeton C; Gecz J; Morgan AT; Costa-Mattioli M
Article: NATURE COMMUNICATIONS. 2019;10(1):5151

eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

Chan K; Robert F; Oertlin C; Kapeller-Libermann D; Avizonis D; Gutierrez J; Handly-Santana A; Doubrovin M; Park J; Schoepfer C; Da Silva B; Yao M; Gorton F; Shi J; Thomas CJ; Brown LE; Porco JAJ; Pollak M; Larsson O; Pelletier J; Chio IIC
Article: CELL DEATH & DISEASE. 2019;10(11):845

RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity

Ristau J; van Hoef V; Peuget S; Zhu J; Guan B-J; Liang S; Hatzoglou M; Topisirovic I; Selivanova G; Larsson O
Article: JCI INSIGHT. 2019;4(21):121951

eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss i n pancreatic cancer

Muller D; Shin S; de Rugy TG; Samain R; Baer R; Strehaiano M; Masvidal-Sanz L; Guillermet-Guibert J; Jean C; Tsukumo Y; Sonenberg N; Marion F; Guilbaud N; Hoffmann J-S; Larsson O; Bousquet C; Pyronnet S; Martineau Y
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2019;200(3):348-358

Distinct Cancer-Promoting Stromal Gene Expression Depending on Lung Function

Sandri BJ; Masvidal L; Murie C; Bartish M; Avdulov S; Higgins L; Markowski T; Peterson M; Bergh J; Yang P; Rolny C; Limper AH; Griffin TJ; Bitterman PB; Wendt CH; Larsson O
Article: NUCLEIC ACIDS RESEARCH. 2019;47(12):e70

Generally applicable transcriptome-wide analysis of translation using anota2seq

Oertlin C; Lorent J; Murie C; Furic L; Topisirovic I; Larsson O
Article: NATURE COMMUNICATIONS. 2019;10(1):2901

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis

Smith HW; Smith HW; Hirukawa A; Sanguin-Gendreau V; Nandi I; Dufour CR; Zuo D; Tandoc K; Leibovitch M; Singh S; Rennhack JP; Swiatnicki M; Lavoie C; Papavasiliou V; Temps C; Carragher NO; Unciti-Broceta A; Savage P; Basik M; van Hoef V; Larsson O; Cooper CL; Calderon ACV; Beith J; Millar E; Selinger C; Giguere V; Park M; Harris LN; Varadan V; Andrechek ER; O'Toole SA; Topisirovic I; Muller WJ
Article: PLOS PATHOGENS. 2019;15(6):e1007842

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery

Gotte B; Panas MD; Hellstrom K; Liu L; Samreen B; Larsson O; Ahola T; McInerney GM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(16):7973-7981

Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis

Morita M; Siddiqui N; Katsumura S; Rouya C; Larsson O; Nagashima T; Hekrnatnejad B; Takahashi A; Kiyonari H; Zang M; St-Arnaud R; Oike Y; Giguere V; Tcpisirovic I; Okada-Hatakeyama M; Yamamoto T; Sonenberg N
Article: CELL METABOLISM. 2018;28(6):817-832.e8

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

Hulea L; Gravel S-P; Morita M; Cargnello M; Uchenunu O; Im YK; Lehuede C; Ma EH; Leibovitch M; McLaughlan S; Blouin M-J; Parisotto M; Papavasiliou V; Lavoie C; Larsson O; Ohh M; Ferreira T; Greenwood C; Bridon G; Avizonis D; Ferbeyre G; Siegel P; Jones RG; Muller W; Ursini-Siegel J; St-Pierre J; Pollak M; Topisirovic I
Article: NUCLEIC ACIDS RESEARCH. 2018;46(15):7772-7792

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease

Timmons JA; Atherton PJ; Larsson O; Sood S; Blokhin IO; Brogan RJ; Volmar C-H; Josse AR; Slentz C; Wahlestedt C; Phillips SM; Phillips BE; Gallagher IJ; Kraus WE
Article: INFECTION AND IMMUNITY. 2018;86(9):e00244-e00218

The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome

Leroux L-P; Lorent J; Graber TE; Chaparro V; Masvidal L; Aguirre M; Fonseca BD; van Kempen LC; Alain T; Larsson O; Jaramillo M
Article: JOURNAL OF IMMUNOLOGY. 2018;200(12):4102-4116

eIF4E-Binding Proteins 1 and 2 Limit Macrophage Anti-Inflammatory Responses through Translational Repression of IL-10 and Cyclooxygenase-2

William M; Leroux L-P; Chaparro V; Lorent J; Graber TE; M'Boutchou M-N; Charpentier T; Fabie A; Dozois CM; Stager S; van Kempen LC; Alain T; Larsson O; Jaramillo M
Article: NUCLEIC ACIDS RESEARCH. 2018;46(1):e3

Polysome-profiling in small tissue samples

Liang S; Bellato HM; Lorent J; Lupinacci FCS; Oertlin C; van Hoef V; Andrade VP; Roffe M; Masvidal L; Hajj GNM; Larsson O
Article: ADVANCES IN BIOLOGICAL REGULATION. 2018;67:128-133

Normalization of mass spectrometry data (NOMAD).

Murie C; Sandri B; Sandberg A-S; Griffin TJ; Lehtiö J; Wendt C; Larsson O
Article: MOLECULAR CELL. 2017;68(5):885-900.e6

A Unique ISR Program Determines Cellular Responses to Chronic Stress

Guan B-J; van Hoef V; Jobava R; Elroy-Stein O; Valasek LS; Cargnello M; Gao X-H; Krokowski D; Merrick WC; Kimball SR; Komar AA; Koromilas AE; Wynshaw-Boris A; Topisirovic I; Larsson O; Hatzoglou M
Article: RNA BIOLOGY. 2017;14(10):1299-1305

mTOR-sensitive translation: Cleared fog reveals more trees

Masvidal L; Hulea L; Furic L; Topisirovic I; Larsson O
Article: MOLECULAR CELL. 2017;67(6):922-935.e5

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1

Morita M; Prudent J; Basu K; Goyon V; Katsumura S; Hulea L; Pearl D; Siddiqui N; Strack S; McGuirk S; St-Pierre J; Larsson O; Topisirovic I; Vali H; McBride HM; Bergeron JJ; Sonenberg N
Article: ONCOGENE. 2016;35(39):5093-5105

Tumor cell survival dependence on the DHX9 DExH-box helicase

Lee T; Paquet M; Larsson O; Pelletier J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(38):E5618-E5627

Pericyte-fibroblast transition promotes tumor growth and metastasis

Hosaka K; Yang Y; Seki T; Fischer C; Dubey O; Fredlund E; Hartman J; Religa P; Morikawa H; Ishii Y; Sasahara M; Larsson O; Cossu G; Cao R; Lim S; Cao Y
Article: BLOOD. 2016;128(11):1475-1489

IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells

Mao Y; van Hoef V; Zhang X; Wennerberg E; Lorent J; Witt K; Masvidal L; Liang S; Murray S; Larsson O; Kiessling R; Lundqvist A
Article: NUCLEIC ACIDS RESEARCH. 2016;44(11):e109

iGEMS: an integrated model for identification of alternative exon usage events

Sood S; Szkop KJ; Nakhuda A; Gallagher IJ; Murie C; Brogan RJ; Kaprio J; Kainulainen H; Atherton PJ; Kujala UM; Gustafsson T; Larsson O; Timmons JA
Article: GENOME RESEARCH. 2016;26(5):636-648

nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs

Gandin V; Masvidal L; Hulea L; Gravel S-P; Cargnello M; McLaughlan S; Cai Y; Balanathan P; Morita M; Rajakumar A; Furic L; Pollak M; Porco JAJ; St-Pierre J; Pelletier J; Larsson O; Topisirovic I
Article: NATURE COMMUNICATIONS. 2016;7:11127

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

Gandin V; Masvidal L; Cargnello M; Gyenis L; McLaughlan S; Cai Y; Tenkerian C; Morita M; Balanathan P; Jean-Jean O; Stambolic V; Trost M; Furic L; Larose L; Koromilas AE; Asano K; Litchfield D; Larsson O; Topisirovic I
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2015;308(12):E1085-E1105

A stringent validation of mouse adipose tissue identity markers

de Jong JMA; Larsson O; Cannon B; Nedergaard J
Article: ONCOGENE. 2015;34(16):2032-2042

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

Robichaud N; del Rincon SV; Huor B; Alain T; Petruccelli LA; Hearnden J; Goncalves C; Grotegut S; Spruck CH; Furic L; Larsson O; Muller WJ; Miller WH; Sonenberg N
Article: CELL CYCLE. 2015;14(4):473-480

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

Morita M; Gravel S-P; Hulea L; Larsson O; Pollak M; St-Pierre J; Topisirovic I
Article: ONCOTARGET. 2015;6(2):604-616

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

Takizawa I; Lawrence MG; Balanathan P; Rebello R; Pearson HB; Garg E; Pedersen J; Pouliot N; Nadon R; Watt MJ; Taylor RA; Humbert P; Topisirovic I; Larsson O; Risbridger GP; Furic L
Article: PLOS ONE. 2015;10(7):e0133482

Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes

Livingstone M; Sikstrom K; Robert PA; Uze G; Larsson O; Pellegrini S
Article: JOURNAL OF PATHOLOGY. 2014;234(1):86-98

A pro-tumourigenic loop at the human prostate tumour interface orchestrated by oestrogen, CXCL12 and mast cell recruitment

Ellem SJ; Taylor RA; Furic L; Larsson O; Frydenberg M; Pook D; Pedersen J; Cawsey B; Trotta A; Need E; Buchanan G; Risbridger GP
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(33):22798-22814

Suppression of the DHX9 Helicase Induces Premature Senescence in Human Diploid Fibroblasts in a p53-dependent Manner

Lee T; Di Paola D; Malina A; Mills JR; Kreps A; Grosse F; Tang H; Zannis-Hadjopoulos M; Larsson O; Pelletier J
Article: JOURNAL OF MOLECULAR CELL BIOLOGY. 2014;6(3):255-266

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner

Miloslavski R; Cohen E; Avraham A; Iluz Y; Hayouka Z; Kasir J; Mudhasani R; Jones SN; Cybulski N; Rueegg MA; Larsson O; Gandin V; Rajakumar A; Topisirovic I; Meyuhas O
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2014;(87):51455

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Gandin V; Sikstrom K; Alain T; Morita M; McLaughlan S; Larsson O; Topisirovic I
Article: JOURNAL OF THORACIC ONCOLOGY. 2014;9(5):639-645

Correlation of Regional Emphysema and Lung Cancer A Lung Tissue Research Consortium-Based Study

Hohberger LA; Schroeder DR; Bartholmai BJ; Yang P; Wendt CH; Bitterman PB; Larsson O; Limper AH
Article: AMERICAN JOURNAL OF PATHOLOGY. 2014;184(5):1369-1383

Identification of a Cell-of-Origin for Fibroblasts Comprising the Fibrotic Reticulum in Idiopathic Pulmonary Fibrosis

Xia H; Bodempudi V; Benyumov A; Hergert P; Tank D; Herrera J; Braziunas J; Larsson O; Parker M; Rossi D; Smith K; Peterson M; Limper A; Jessurun J; Connett J; Ingbar D; Sem P; Bitterman PB; Henke CA
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(4):1622-1635

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

Parker MW; Rossi D; Peterson M; Smith K; Sikstrom K; White ES; Connett JE; Henke CA; Larsson O; Bitterman PB
Article: PROSTATE. 2013;73(16):1810-1823

Hedgehog Signaling Is Active in Human Prostate Cancer Stroma and Regulates Proliferation and Differentiation of Adjacent Epithelium

Wilkinson SE; Furic L; Buchanan G; Larsson O; Pedersen J; Frydenberg M; Risbridger GP; Taylor RA
Article: CELL METABOLISM. 2013;18(5):698-711

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

Morita M; Gravel S-P; Chenard V; Sikstrom K; Zheng L; Alain T; Gandin V; Avizonis D; Arguello M; Zakaria C; McLaughlan S; Nouet Y; Pause A; Pollak M; Gottlieb E; Larsson O; St-Pierre J; Topisirovic I; Sonenberg N
Article: PLOS GENETICS. 2013;9(5):e1003494

Distinct Translational Control in CD4⁺ T Cell Subsets

Bjur E; Larsson O; Yurchenko E; Zheng L; Gandin V; Topisirovic I; Li S; Wagner CR; Sonenberg N; Piccirillo CA
Article: BLOOD. 2013;121(17):3402-3412

RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model

Mills JR; Malina A; Lee T; Di Paola D; Larsson O; Miething C; Grosse F; Tang H; Zannis-Hadjopoulos M; Lowe SW; Pelletier J
Article: TRANSLATION. 2013;1(1):e24557

Re-analysis of genome wide data on mammalian microRNA-mediated suppression of gene expression.

Larsson O; Nadon R
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2013;5(1):a012302

Toward a Genome-Wide Landscape of Translational Control

Larsson O; Tian B; Sonenberg N
Article: NATURE COMMUNICATIONS. 2013;4:2129

Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis

Hosaka K; Yang Y; Seki T; Nakamura M; Andersson P; Rouhi P; Yang X; Jensen L; Lim S; Feng N; Xue Y; Li X; Larsson O; Ohhashi T; Cao Y
Article: MOLECULAR AND CELLULAR BIOLOGY. 2012;32(17):3585-3593

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

Morita M; Ler LW; Fabian MR; Siddiqui N; Mullin M; Henderson VC; Alain T; Fonseca BD; Karashchuk G; Bennett CF; Kabuta T; Higashi S; Larsson O; Topisirovic I; Smith RJ; Gingras A-C; Sonenberg N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(24):9551-9556

Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors

Edlund K; Larsson O; Ameur A; Bunikis I; Gyllensten U; Leroy B; Sundstrom M; Micke P; Botling J; Soussi T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(23):8977-8982

Distinct perturbation of the translatome by the antidiabetic drug metformin

Larsson O; Morita M; Topisirovic I; Alain T; Blouin M-J; Pollak M; Sonenberg N
Article: NATURE MEDICINE. 2011;18(1):100-110

PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells

Xue Y; Lim S; Yang Y; Wang Z; Jensen LDE; Hedlund E-M; Andersson P; Sasahara M; Larsson O; Galter D; Gao R; Hosaka K; Cao Y
Article: BIOINFORMATICS. 2011;27(10):1440-1441

anota: analysis of differential translation in genome-wide studies

Larsson O; Sonenberg N; Nadon R
Article: CELL HOST & MICROBE. 2011;9(4):331-341

Leishmania Repression of Host Translation through mTOR Cleavage Is Required for Parasite Survival and Infection

Jaramillo M; Gomez MA; Larsson O; Shio MT; Topisirovic I; Contreras I; Luxenburg R; Rosenfeld A; Colina R; McMaster RW; Olivier M; Costa-Mattioli M; Sonenberg N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(50):21487-21492

Identification of differential translation in genome wide studies

Larsson O; Sonenberg N; Nadon R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(32):14134-14139

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

Furic L; Rong L; Larsson O; Koumakpayi IH; Yoshida K; Brueschke A; Petroulakis E; Robichaud N; Pollak M; Gaboury LA; Pandolfi PP; Saad F; Sonenberg N
Article: SCIENCE. 2010;328(5982):1172-1176

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

Dowling RJO; Topisirovic I; Alain T; Bidinosti M; Fonseca BD; Petroulakis E; Wang X; Larsson O; Selvaraj A; Liu Y; Kozma SC; Thomas G; Sonenberg N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(52):22217-22222

The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis

Parsyan A; Shahbazian D; Martineau Y; Petroulakis E; Alain T; Larsson O; Mathonnet G; Tettweiler G; Hellen CU; Pestova TV; Svitkin YV; Sonenberg N
Article: CHEMISTRY AND BIOLOGY. 2009;16(12):1240-1249

A Chemical Genetic Screen for mTOR Pathway Inhibitors Based on 4E-BP-Dependent Nuclear Accumulation of eIF4E

Livingstone M; Larsson O; Sukarieh R; Pelletier J; Sonenberg N
Article: CANCER CELL. 2009;16(5):439-446

p53-Dependent Translational Control of Senescence and Transformation via 4E-BPs

Petroulakis E; Parsyan A; Dowling RJO; LeBacquer O; Martineau Y; Bidinosti M; Larsson O; Alain T; Rong L; Mamane Y; Paquet M; Furic L; Topisirovic I; Shahbazian D; Livingstone M; Costa-Mattioli M; Teodoro JG; Sonenberg N
Article: CANCER RESEARCH. 2009;69(21):8455-8462

Eukaryotic Initiation Factor 4E Binding Protein Family of Proteins: Sentinels at a Translational Control Checkpoint in Lung Tumor Defense

Kim YY; Von Weymarn L; Larsson O; Fan D; Underwood JM; Peterson MS; Hecht SS; Polunovsky VA; Bitterman PB
Article: RNA. 2009;15(8):1469-1482

Regulatory element identification in subsets of transcripts: Comparison and integration of current computational methods

Fan D; Bitterman PB; Larsson O
Article: CELL METABOLISM. 2009;9(1):99-109

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

Xue Y; Petrovic N; Cao R; Larsson O; Lim S; Chen S; Feldmann HM; Liang Z; Zhu Z; Nedergaard J; Cannon B; Cao Y
Article: PROSTATE. 2009;69(1):33-40

Insulin Receptor Expression by Human Prostate Cancers

Cox ME; Gleave ME; Zakikhani M; Bell RH; Piura E; Vickers E; Cunningham M; Larsson O; Fazli L; Pollak M
Article: PLOS ONE. 2009;4(3):e4868

Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E-A Computational Inference

Santhanam AN; Bindewald E; Rajasekhar VK; Larsson O; Sonenberg N; Colburn NH; Shapiro BA
Article: PLOS ONE. 2008;3(9):e3220

Fibrotic Myofibroblasts Manifest Genome-Wide Derangements of Translational Control

Larsson O; Diebold D; Fan D; Peterson M; Nho RS; Bitterman PB; Henke CA
Article: NATURE. 2008;452(7185):323-328

Translational control of the innate immune response through IRF-7

Colina R; Costa-Mattioli M; Dowling RJO; Jaramillo M; Tai L-H; Breitbach CJ; Martineau Y; Larsson O; Rong L; Svitkin YV; Makrigiannis AP; Bell JC; Sonenberg N
Article: MOLECULAR CELL. 2008;29(2):263-270

Conserved GU-rich elements mediate mRNA decay by binding to CUG-binding protein 1

Vlasova IA; Tahoe NM; Fan D; Larsson O; Rattenbacher B; John JRS; Vasdewani J; Karypis G; Reilly CS; Bitterman PB; Bohjanen PR
Article: FASEB JOURNAL. 2007;21(13):3653-3665

Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?

Scheele C; Nielsen AR; Walden TB; Sewell DA; Fischer CP; Brogan RJ; Petrovic N; Larsson O; Tesch PA; Wennmalm K; Hutchinson DS; Cannon B; Wahlestedt C; Pedersen BK; Timmons JA
Article: CANCER RESEARCH. 2007;67(14):6814-6824

Eukaryotic translation initiation factor 4E-Induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors

Larsson O; Li S; Issaenko OA; Avdulov S; Peterson M; Smith K; Bitterman PB; Polunovsky VA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(11):4401-4406

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages

Timmons JA; Wennmalm K; Larsson O; Walden TB; Lassmann T; Petrovic N; Hamilton DL; Gimeno RE; Wahlestedt C; Baar K; Nedergaard J; Cannon B
Article: PLOS ONE. 2007;2(2):e242

Epigenetic Activation of a Subset of mRNAs by eIF4E Explains Its Effects on Cell Proliferation

Mamane Y; Petroulakis E; Martineau Y; Sato T-A; Larsson O; Rajasekhar VK; Sonenberg N
Article: BMC BIOINFORMATICS. 2007;8:48

Improved precision and accuracy for microarrays using updated probe set definitions

Sandberg R; Larsson O
Article: NUCLEIC ACIDS RESEARCH. 2006;34(16):4375-4386

Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure

Larsson O; Perlman DM; Fan D; Reilly CS; Peterson M; Dahlgren C; Liang Z; Li S; Polunovsky VA; Wahlestedt C; Bitterman PB
Article: OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY. 2006;10(3):381-397

Comparative microarray analysis

Larsson O; Wennmalm K; Sandberg R
Article: FASEB JOURNAL. 2005;19(7):750-760

Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy

Timmons JA; Larsson O; Jansson E; Fischer H; Gustafsson T; Greenhaff PL; Ridden P; Rachman J; Peyrard-Janvid M; Wahlestedt C; Sundberg CJ
Article: GENOME BIOLOGY. 2005;6(13):R109

The expression signature of in vitro senescence resembles mouse but not human aging

Wennmalm K; Wahlestedt C; Larsson O
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;316(3):680-687

Functional comparison of single- and double-stranded siRNAs in mammalian cells

Xu YH; Linde A; Larsson A; Thormeyer D; Elmen J; Wahlestedt C; Liang ZC
Article: CANCER RESEARCH. 2004;64(2):482-489

Kinetics of senescence-associated changes of gene expression in an epithelial, temperature-sensitive SV40 large T antigen model

Larsson O; Scheele C; Liang ZC; Moll J; Karlsson C; Wahlestedt C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;306(3):712-717

Effective small interfering RNAs and phosphorothioate antisense DNAs have different preferences for target sites in the luciferase mRNAs

Xu YH; Zhang HY; Thormeyer D; Larsson A; Du Q; Elmén J; Wahlestedt C; Liang Z
Article: BIOTECHNIQUES. 2003;34(2):346-355

Characterization of lacZ complementation deletions using membrane receptor dimerization

Thormeyer D; Ammerpohl O; Larsson O; Xu Y; Asinger A; Wahlestedt C; Liang Z
Article: NUCLEIC ACIDS RESEARCH. 2002;30(23):e133

Quantitative codon optimisation of DNA libraries encoding sub-random peptides:: design and characterisation of a novel library encoding transmembrane domain peptides -: art. no. e133

Larsson O; Thormeyer D; Asinger A; Wihlén B; Wahlestedt C; Liang Z
Article: NATURE BIOTECHNOLOGY. 2001;19(4):360-364

Bactericidal antisense effects of peptide-PNA conjugates

Good L; Awasthi SK; Dryselius R; Larsson O; Nielsen PE
Article: MICROBIOLOGY-SGM. 2000;146:2665-2670

Antisense PNA effects in Escherichia coli are limited by the outer-membrane LPS layer

Good L; Sandberg R; Larsson O; Nielsen PE; Wahlestedt C
Article: NUCLEIC ACIDS RESEARCH. 2000;28(14):E71

Silanized nucleic acids: a general platform for DNA immobilization.

Kumar A; Larsson O; Parodi D; Liang Z
Visa fler

Alla övriga publikationer

Preprint: BIORXIV. 2023

Epigenetic coordination of transcriptional and translational programs in hypoxia

Watt K; Dauber B; Szkop K; Lee L; Jovanovic P; Chen S; Masvidal L; Tandoc K; Palia R; Topisirovic I; Larsson O; Postovit L-M
Review: NATURE REVIEWS CANCER. 2023;23(6):408-425

The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment

Bartish M; Abraham MJ; Goncalves C; Larsson O; Rolny C; Del Rincon SV
Preprint: RES SQ. 2023;RES SQ

Translatome analysis of Tuberous Sclerosis Complex-1 patient-derived neural progenitor cells reveal rapamycin-dependent and independent alterations.

Aksoylu IS; Martin P; Robert F; Szkop KJ; Redmond NE; Chen S; Beauchamp RL; Nobeli I; Pelletier J; Larsson O; Ramesh V
Preprint: BIORXIV. 2023

Amino acid usage and tRNA expression underlies proteome adaptation inPlasmodium falciparum

Li Q; Vetter L; Veith Y; Christ E; Végvári Á; Sahin C; Ribacke U; Wahlgren M; Ankarklev J; Larsson O; Chan SC-L
Review: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2022;1869(1):119140

Regulation of gene expression via translational buffering

Kusnadi EP; Timpone C; Topisirovic I; Larsson O; Furic L
Corrigendum: NATURE CHEMICAL BIOLOGY. 2021;17(11):1209

Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth (vol 17, pg 1065, 2021)

Lee BJ; Boyer JA; Burnett GL; Thottumkara AP; Tibrewal N; Wilson SL; Hsieh T; Marquez A; Lorenzana EG; Evans JW; Hulea L; Kiss G; Liu H; Lee D; Larsson O; McLaughlan S; Topisirovic I; Wang Z; Wang Z; Zhao Y; Wildes D; Aggen JB; Singh M; Gill AL; Smith JAM; Rosen N
Preprint: BIORXIV. 2021

Regulatory start-stop elements in 5’ untranslated regions pervasively modulate translation

Rendleman J; Haizel S; Wu S; Liu J; Ge X; Zou H; Mohammad MP; Pressler M; Maity S; Hronová V; Gao Z; Herrmannová A; Lei A; Allgoewer K; Sultanov D; Hinckley WE; Cheng Z; Shelby L; Szkop K; Topisirovic I; Larsson O; Hatzoglou M; Valášek LS; Vogel C
Conference publication: EUROPEAN JOURNAL OF CANCER. 2020;138:S23

The integrated stress response exposes a therapeutic vulnerability in KRAS driven lung cancer

Ghaddar N; Wang S; Woodvine B; Krishnamoorthy J; Darini C; Van Hoef V; Popper H; Topisirovic I; Larsson O; Le Quesne J; Koromilas A
Review: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. 2017;1868(2):484-499

Cancer as an ecomolecular disease and a neoplastic consortium

Ramon y Cajal S; Capdevila C; Hernandez-Losa J; De Mattos-Arruda L; Ghosh A; Lorent J; Larsson O; Aasen T; Postovit L-M; Topisirovic I
Review: NATURE IMMUNOLOGY. 2014;15(6):503-511

Translational control of immune responses: from transcripts to translatomes

Piccirillo CA; Bjur E; Topisirovic I; Sonenberg N; Larsson O
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2009;457:211-229

USING FUNCTIONAL GENOMICS TO STUDY PINK1 AND METABOLIC PHYSIOLOGY

Scheele C; Larsson O; Timmons JA
Review: BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS. 2008;25:77-92

Gene Expression - Time to Change Point of View?

Larsson O; Nadon R
Letter: NATURE BIOTECHNOLOGY. 2006;24(11):1322-1323

Lack of correct data format and comparability limits future integrative microarray research

Larsson O; Sandberg R
Letter: BMC BIOINFORMATICS. 2005;6:129

Considerations when using the significance analysis of microarrays (SAM) algorithm

Larsson O; Wahlestedt C; Timmons JA
Thesis / dissertation: 2005

Transcriptome studies of cell-fate and aging

Larsson, Ola
Review: TOPICS IN CURRENT CHEMISTRY. 2005;261:45-61

DNA immobilization: Silanized nucleic acids and nanoprinting

Du Q; Larsson O; Swerdlow H; Liang Z

Forskningsbidrag

Translational Control In Plasmodiuim falciparum

Swedish Research Council

1 January 2022 - 31 December 2025
Examining the MNK1/2-eIF4E axis in cancer associated fibroblasts as a driver of oncogenic progression

Canadian Cancer Society

1 May 2021 - 30 April 2026
Targeting mRNA translation to reverse resistance to endocrine therapy

Swedish Research Council

1 December 2020 - 31 December 2022
Targeting mRNA translation to reverse resistance to endocrine therapy

Swedish Cancer Society

1 January 2019
Codon bias: a hidden layer of translational regulation by estrogens

National Health and Medical Research Council

1 January 2018 - 31 December 2020
Mechanistic dissection of the eIF4F complex in breast cancer

Swedish Research Council

1 January 2017 - 31 December 2020
Identification of mechanisms facilitating oncogenic mRNA translation

Swedish Research Council

1 January 2014 - 31 December 2016
Utredning av betydelsen för translationell kontroll av genuttryck i bröstcancer

Swedish Research Council

1 January 2010 - 31 December 2013
Utredning av betydelsen för translationell kontroll av genuttryck i bröstcancer

Swedish Research Council

1 January 2010 - 31 December 2013

Anställningar

Senior Forskare, Onkologi-Patologi, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Experimentell onkologi, Karolinska Institutet, 2016
MEDICINE DOKTORSEXAMEN, CENTRUM FÖR GENOMFORSKNING (C9), Karolinska Institutet, 2005
Medicine Magisterexamen, Karolinska Institutet, 2000

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI