Ola Larsson
Principal Researcher | Head of department | Docent
E-mail: ola.larsson@ki.se
Telephone: +46852481228
Visiting address: SciLifeLab, Tomtebodavägen 23A, 17121 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Larsson Ola, 171 77 Stockholm
Articles
- Article: MATRIX BIOLOGY. 2025;140:1-15Goransson S; Olofsson H; Johansson HJ; Yan F; Vogiatzakis C; Liang S; Bellato HM; Masvidal L; Aksoylu I; Hartman J; Hajj GNM; Larsson O; Lehtio J; Stromblad S
- Journal article: NATURE METHODS. 2025;:1-5Świrski MI; Tierney JAS; Albà MM; Andreev DE; Aspden JL; Atkins JF; Bassani-Sternberg M; Berry MJ; Biffo S; Boris-Lawrie K; Borodovsky M; Brierley I; Brook M; Brunet MA; Bujnicki JM; Caliskan N; Calviello L; Carvunis A-R; Cate JHD; Cenik C; Chang KY; Chen Y; Chothani S; Choudhary JS; Clark PL; Clauwaert J; Cooley L; Dassi E; Dean K; Diaz J-J; Dieterich C; Dikstein R; Dinman JD; Dmitriev SE; Dontsova OA; Dunham CM; Eswarappa SM; Farabaugh PJ; Faridi P; Fierro-Monti I; Firth AE; Gatfield D; Gebauer F; Gelfand MS; Gray NK; Green R; Hill CH; Hou Y-M; Hübner N; Ignatova Z; Ivanov P; Iwasaki S; Johnson R; Jomaa A; Jovanovic M; Jungreis I; Kellis M; Kieft JS; Kochetov AV; Koonin EV; Korostelev AA; Kufel J; Kulakovskiy IV; Kurian L; Lafontaine DLJ; Larsson O; Loughran G; Lukeš J; Mariotti M; Martens-Uzunova ES; Martinez TF; Matsumoto A; McManus J; Medenbach J; Melnikov SV; Menschaert G; Merchante C; Mikl M; Miller WA; Mühlemann O; Namy O; Nedialkova DD; Nosek J; Orchard S; Ozretić P; Pertea M; Pervouchine DD; Romão L; Ron D; Roucou X; Rubtsova MP; Ruiz-Orera J; Saghatelian A; Salzberg SL; Seale LA; Seoighe C; Sergiev PV; Shah P; Shirokikh N; Slavoff SA; Sonenberg N; Stasevich TJ; Szczesny RJ; Tamm T; Tchórzewski M; Topisirovic I; Tremblay ML; Tuller T; Ulitsky I; Valášek LS; Van Damme P; Viero G; Vizcaino JA; Vogel C; Wallace EWJ; Weissman JS; Westhof E; Whiffin N; Wilson DN; Xie Z; Yewdell JW; Yordanova MM; Yu C-H; Yurchenko V; Zagrovic B; TRANSLACORE; Valen E; Baranov PV
- Article: BRAIN. 2025;148(8):2935-2950Martin P; Szkop KJ; Robert F; Bhattacharyya S; Beauchamp RL; Brenner J; Redmond NE; Huang S; Erdin S; Larsson O; Ramesh V
- Article: NATURE. 2025;641(8065):1319-1328Chen C-W; Papadopoli D; Szkop KJ; Guan B-J; Alzahrani M; Wu J; Jobava R; Asraf MM; Krokowski D; Vourekas A; Merrick WC; Komar AA; Koromilas AE; Gorospe M; Payea MJ; Wang F; Clayton BLL; Tesar PJ; Schaffer A; Miron A; Bederman I; Jankowsky E; Vogel C; Valasek LS; Dinman JD; Zhang Y; Tirosh B; Larsson O; Topisirovic I; Hatzoglou M
- Article: AUTOPHAGY. 2025;21(5):996-1018Liu J; Nagy N; Ayala-Torres C; Bleuse S; Aguilar-Alonso F; Larsson O; Masucci MG
- Article: ISCIENCE. 2024;27(11):111167Li Q; Vetter L; Veith Y; Christ E; Vegvari A; Sahin C; Ribacke U; Wahlgren M; Ankarklev J; Larsson O; Chan SC-L
- Article: NATURE. 2024;632(8025):656-663Park J; Wu J; Szkop KJ; Jeong J; Jovanovic P; Husmann D; Flores NM; Francis JW; Chen Y-JC; Benitez AM; Zahn E; Song S; Ajani JA; Wang L; Singh K; Larsson O; Garcia BA; Topisirovic I; Gozani O; Mazur PK
- Article: MOLECULAR AUTISM. 2023;14(1):39Aksoylu IS; Martin P; Robert F; Szkop KJ; Redmond NE; Bhattacharyya S; Wang J; Chen S; Beauchamp RL; Nobeli I; Pelletier J; Larsson O; Ramesh V
- Article: SCIENCE ADVANCES. 2023;9(30):eadg1805Pederiva C; Trevisan DM; Peirasmaki D; Chen S; Savage SA; Larsson O; Ule J; Baranello L; Agostini F; Farnebo M
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2023;654:73-79Goransson S; Chen S; Olofsson H; Larsson O; Stromblad S
- Article: NATURE CHEMICAL BIOLOGY. 2022;18(9):942-953Karampelias C; Watt K; Mattsson CL; Ruiz AF; Rezanejad H; Mi J; Liu X; Chu L; Locasale JW; Korbutt GS; Rovira M; Larsson O; Andersson O
- Article: CELL REPORTS. 2022;40(3):111092Krokowski D; Jobava R; Szkop KJ; Chen C-W; Fu X; Venus S; Guan B-J; Wu J; Gao Z; Banaszuk W; Tchorzewski M; Mu T; Ropelewski P; Merrick WC; Mao Y; Sevval AI; Miranda H; Qian S-B; Manifava M; Ktistakis NT; Vourekas A; Jankowsky E; Topisirovic I; Larsson O; Hatzoglou M
- Article: CELL METABOLISM. 2022;34(4):564-580.e8Katsumura S; Siddiqui N; Goldsmith MR; Cheah JH; Fujikawa T; Minegishi G; Yamagata A; Yabuki Y; Kobayashi K; Shirouzu M; Inagaki T; Huang TH-M; Musi N; Topisirovic I; Larsson O; Morita M
- Article: EMBO JOURNAL. 2022;41(6):e108650Kajjo S; Sharma S; Chen S; Brothers WR; Cott M; Hasaj B; Jovanovic P; Larsson O; Fabian MR
- Article: NATURE COMMUNICATIONS. 2022;13(1):1100Smith LK; Parmenter T; Kleinschmidt M; Kusnadi EP; Kang J; Martin CA; Lau P; Patel R; Lorent J; Papadopoli D; Trigos A; Ward T; Rao AD; Lelliott EJ; Sheppard KE; Goode D; Hicks RJ; Tiganis T; Simpson KJ; Larsson O; Blythe B; Cullinane C; Wickramasinghe VO; Pearson RB; McArthur GA
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:243-268Oertlin C; Watt K; Ristau J; Larsson O
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:223-241Ristau J; Watt K; Oertlin C; Larsson O
- Journal article: NATURE CHEMICAL BIOLOGY. 2021;17(11):1209Lee BJ; Boyer JA; Burnett GL; Thottumkara AP; Tibrewal N; Wilson SL; Hsieh T; Marquez A; Lorenzana EG; Evans JW; Hulea L; Kiss G; Liu H; Lee D; Larsson O; McLaughlan S; Topisirovic I; Wang Z; Wang Z; Zhao Y; Wildes D; Aggen JB; Singh M; Gill AL; Smith JAM; Rosen N
- Article: NATURE CHEMICAL BIOLOGY. 2021;17(10):1065-1074Lee BJ; Boyer JA; Burnett GL; Thottumkara AP; Tibrewal N; Wilson SL; Hsieh T; Marquez A; Lorenzana EG; Evans JW; Hulea L; Kiss G; Liu H; Lee D; Larsson O; McLaughlan S; Topisirovic I; Wang Z; Wang Z; Zhao Y; Wildes D; Aggen JB; Singh M; Gill AL; Smith JAM; Rosen N
- Article: NATURE COMMUNICATIONS. 2021;12(1):4651Ghaddar N; Wang S; Woodvine B; Krishnamoorthy J; van Hoef V; Darini C; Kazimierczak U; Ah-son N; Popper H; Johnson M; Officer L; Teodosio A; Broggini M; Mann KK; Hatzoglou M; Topisirovic I; Larsson O; Le Quesne J; Koromilas AE
- Article: SCIENCE ADVANCES. 2021;7(22):eabf0971Kaspar S; Oertlin C; Szczepanowska K; Kukat A; Senft K; Lucas C; Brodesser S; Hatzoglou M; Larsson O; Topisirovic I; Trifunovic A
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(44):27556-27565Bartish M; Tong D; Pan Y; Wallerius M; Liu H; Ristau J; Ferreira SDS; Wallmann T; van Hoef V; Masvidal L; Kerzel T; Joly A-L; Goncalves C; Preston SEJ; Ebrahimian T; Seitz C; Bergh J; Pietras K; Lehoux S; Naldini L; Andersson J; Squadrito ML; del RSV; Larsson O; Rolny C
- Article: EMBO JOURNAL. 2020;39(21):e105111Kusnadi EP; Trigos AS; Cullinane C; Goode DL; Larsson O; Devlin JR; Chan KT; De Souza DP; McConville MJ; McArthur GA; Thomas G; Sanij E; Poortinga G; Hannan RD; Hannan KM; Kang J; Pearson RB
- Article: MOLECULAR CANCER RESEARCH. 2020;18(10):1560-1573Lazar I; Fabre B; Feng Y; Khateb A; Turko P; Gomez JMM; Frederick DT; Levesque MP; Feld L; Zhang G; Zhang T; James B; Shklover J; Avitan-Hersh E; Livneh I; Scortegagna M; Brown K; Larsson O; Topisirovic I; Wolfenson H; Herlyn M; Flaherty K; Dummer R; Ronai ZA
- Article: PLOS PATHOGENS. 2020;16(6):e1008291Chaparro V; Leroux L-P; Masvidal L; Lorent J; Graber TE; Zimmermann A; Duque GA; Descoteaux A; Alain T; Larsson O; Jaramillo M
- Article: EMBO JOURNAL. 2019;38(23):e101323Lorent J; Kusnadi EP; van Hoef V; Rebello RJ; Leibovitch M; Ristau J; Chen S; Lawrence MG; Szkop KJ; Samreen B; Balanathan P; Rapino F; Close P; Bukczynska P; Scharmann K; Takizawa I; Risbridger GP; Selth LA; Leidel SA; Lin Q; Topisirovic I; Larsson O; Furic L
- Article: PLOS BIOLOGY. 2019;17(12):e3000535Hipolito VEB; Diaz JA; Tandoc KV; Oertlin C; Ristau J; Chauhan N; Saric A; Mclaughlan S; Larsson O; Topisirovic I; Botelho RJ
- Article: NEURON. 2019;104(4):665-679.e8Johnson JL; Stoica L; Liu Y; Zhu PJ; Bhattacharya A; Buffington SA; Huq R; Eissa NT; Larsson O; Porse BT; Domingo D; Nawaz U; Carroll R; Jolly L; Scerri TS; Kim H-G; Brignell A; Coleman MJ; Braden R; Kini U; Jackson V; Baxter A; Bahlo M; Scheffer IE; Amor DJ; Hildebrand MS; Bonnen PE; Beeton C; Gecz J; Morgan AT; Costa-Mattioli M
- Article: NATURE COMMUNICATIONS. 2019;10(1):5151Chan K; Robert F; Oertlin C; Kapeller-Libermann D; Avizonis D; Gutierrez J; Handly-Santana A; Doubrovin M; Park J; Schoepfer C; Da Silva B; Yao M; Gorton F; Shi J; Thomas CJ; Brown LE; Porco JAJ; Pollak M; Larsson O; Pelletier J; Chio IIC
- Article: CELL DEATH & DISEASE. 2019;10(11):845Ristau J; van Hoef V; Peuget S; Zhu J; Guan B-J; Liang S; Hatzoglou M; Topisirovic I; Selivanova G; Larsson O
- Article: JCI INSIGHT. 2019;4(21):121951Muller D; Shin S; de Rugy TG; Samain R; Baer R; Strehaiano M; Masvidal-Sanz L; Guillermet-Guibert J; Jean C; Tsukumo Y; Sonenberg N; Marion F; Guilbaud N; Hoffmann J-S; Larsson O; Bousquet C; Pyronnet S; Martineau Y
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2019;200(3):348-358Sandri BJ; Masvidal L; Murie C; Bartish M; Avdulov S; Higgins L; Markowski T; Peterson M; Bergh J; Yang P; Rolny C; Limper AH; Griffin TJ; Bitterman PB; Wendt CH; Larsson O
- Article: NUCLEIC ACIDS RESEARCH. 2019;47(12):e70Oertlin C; Lorent J; Murie C; Furic L; Topisirovic I; Larsson O
- Article: NATURE COMMUNICATIONS. 2019;10(1):2901Smith HW; Smith HW; Hirukawa A; Sanguin-Gendreau V; Nandi I; Dufour CR; Zuo D; Tandoc K; Leibovitch M; Singh S; Rennhack JP; Swiatnicki M; Lavoie C; Papavasiliou V; Temps C; Carragher NO; Unciti-Broceta A; Savage P; Basik M; van Hoef V; Larsson O; Cooper CL; Calderon ACV; Beith J; Millar E; Selinger C; Giguere V; Park M; Harris LN; Varadan V; Andrechek ER; O'Toole SA; Topisirovic I; Muller WJ
- Article: PLOS PATHOGENS. 2019;15(6):e1007842Gotte B; Panas MD; Hellstrom K; Liu L; Samreen B; Larsson O; Ahola T; McInerney GM
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(16):7973-7981Morita M; Siddiqui N; Katsumura S; Rouya C; Larsson O; Nagashima T; Hekrnatnejad B; Takahashi A; Kiyonari H; Zang M; St-Arnaud R; Oike Y; Giguere V; Tcpisirovic I; Okada-Hatakeyama M; Yamamoto T; Sonenberg N
- Article: CELL METABOLISM. 2018;28(6):817-832.e8Hulea L; Gravel S-P; Morita M; Cargnello M; Uchenunu O; Im YK; Lehuede C; Ma EH; Leibovitch M; McLaughlan S; Blouin M-J; Parisotto M; Papavasiliou V; Lavoie C; Larsson O; Ohh M; Ferreira T; Greenwood C; Bridon G; Avizonis D; Ferbeyre G; Siegel P; Jones RG; Muller W; Ursini-Siegel J; St-Pierre J; Pollak M; Topisirovic I
- Article: NUCLEIC ACIDS RESEARCH. 2018;46(15):7772-7792Timmons JA; Atherton PJ; Larsson O; Sood S; Blokhin IO; Brogan RJ; Volmar C-H; Josse AR; Slentz C; Wahlestedt C; Phillips SM; Phillips BE; Gallagher IJ; Kraus WE
- Article: INFECTION AND IMMUNITY. 2018;86(9):e00244-e00218Leroux L-P; Lorent J; Graber TE; Chaparro V; Masvidal L; Aguirre M; Fonseca BD; van Kempen LC; Alain T; Larsson O; Jaramillo M
- Article: JOURNAL OF IMMUNOLOGY. 2018;200(12):4102-4116William M; Leroux L-P; Chaparro V; Lorent J; Graber TE; M'Boutchou M-N; Charpentier T; Fabie A; Dozois CM; Stager S; van Kempen LC; Alain T; Larsson O; Jaramillo M
- Article: NUCLEIC ACIDS RESEARCH. 2018;46(1):e3Liang S; Bellato HM; Lorent J; Lupinacci FCS; Oertlin C; van Hoef V; Andrade VP; Roffe M; Masvidal L; Hajj GNM; Larsson O
- Article: ADVANCES IN BIOLOGICAL REGULATION. 2018;67:128-133Murie C; Sandri B; Sandberg A-S; Griffin TJ; Lehtiö J; Wendt C; Larsson O
- Article: MOLECULAR CELL. 2017;68(5):885-900.e6Guan B-J; van Hoef V; Jobava R; Elroy-Stein O; Valasek LS; Cargnello M; Gao X-H; Krokowski D; Merrick WC; Kimball SR; Komar AA; Koromilas AE; Wynshaw-Boris A; Topisirovic I; Larsson O; Hatzoglou M
- Article: RNA BIOLOGY. 2017;14(10):1299-1305Masvidal L; Hulea L; Furic L; Topisirovic I; Larsson O
- Article: MOLECULAR CELL. 2017;67(6):922-935.e5Morita M; Prudent J; Basu K; Goyon V; Katsumura S; Hulea L; Pearl D; Siddiqui N; Strack S; McGuirk S; St-Pierre J; Larsson O; Topisirovic I; Vali H; McBride HM; Bergeron JJ; Sonenberg N
- Article: ONCOGENE. 2016;35(39):5093-5105Lee T; Paquet M; Larsson O; Pelletier J
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(38):E5618-E5627Hosaka K; Yang Y; Seki T; Fischer C; Dubey O; Fredlund E; Hartman J; Religa P; Morikawa H; Ishii Y; Sasahara M; Larsson O; Cossu G; Cao R; Lim S; Cao Y
- Article: BLOOD. 2016;128(11):1475-1489Mao Y; van Hoef V; Zhang X; Wennerberg E; Lorent J; Witt K; Masvidal L; Liang S; Murray S; Larsson O; Kiessling R; Lundqvist A
- Article: NUCLEIC ACIDS RESEARCH. 2016;44(11):e109Sood S; Szkop KJ; Nakhuda A; Gallagher IJ; Murie C; Brogan RJ; Kaprio J; Kainulainen H; Atherton PJ; Kujala UM; Gustafsson T; Larsson O; Timmons JA
- Article: GENOME RESEARCH. 2016;26(5):636-648Gandin V; Masvidal L; Hulea L; Gravel S-P; Cargnello M; McLaughlan S; Cai Y; Balanathan P; Morita M; Rajakumar A; Furic L; Pollak M; Porco JAJ; St-Pierre J; Pelletier J; Larsson O; Topisirovic I
- Article: NATURE COMMUNICATIONS. 2016;7:11127Gandin V; Masvidal L; Cargnello M; Gyenis L; McLaughlan S; Cai Y; Tenkerian C; Morita M; Balanathan P; Jean-Jean O; Stambolic V; Trost M; Furic L; Larose L; Koromilas AE; Asano K; Litchfield D; Larsson O; Topisirovic I
- Article: PLOS ONE. 2015;10(7):e0133482Livingstone M; Sikstrom K; Robert PA; Uze G; Larsson O; Pellegrini S
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2015;308(12):E1085-E1105de Jong JMA; Larsson O; Cannon B; Nedergaard J
- Article: ONCOGENE. 2015;34(16):2032-2042Robichaud N; del Rincon SV; Huor B; Alain T; Petruccelli LA; Hearnden J; Goncalves C; Grotegut S; Spruck CH; Furic L; Larsson O; Muller WJ; Miller WH; Sonenberg N
- Article: CELL CYCLE. 2015;14(4):473-480Morita M; Gravel S-P; Hulea L; Larsson O; Pollak M; St-Pierre J; Topisirovic I
- Article: ONCOTARGET. 2015;6(2):604-616Takizawa I; Lawrence MG; Balanathan P; Rebello R; Pearson HB; Garg E; Pedersen J; Pouliot N; Nadon R; Watt MJ; Taylor RA; Humbert P; Topisirovic I; Larsson O; Risbridger GP; Furic L
- Article: JOURNAL OF PATHOLOGY. 2014;234(1):86-98Ellem SJ; Taylor RA; Furic L; Larsson O; Frydenberg M; Pook D; Pedersen J; Cawsey B; Trotta A; Need E; Buchanan G; Risbridger GP
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(33):22798-22814Lee T; Di Paola D; Malina A; Mills JR; Kreps A; Grosse F; Tang H; Zannis-Hadjopoulos M; Larsson O; Pelletier J
- Article: JOURNAL OF MOLECULAR CELL BIOLOGY. 2014;6(3):255-266Miloslavski R; Cohen E; Avraham A; Iluz Y; Hayouka Z; Kasir J; Mudhasani R; Jones SN; Cybulski N; Rueegg MA; Larsson O; Gandin V; Rajakumar A; Topisirovic I; Meyuhas O
- Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2014;(87):51455Gandin V; Sikstrom K; Alain T; Morita M; McLaughlan S; Larsson O; Topisirovic I
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2014;184(5):1369-1383Xia H; Bodempudi V; Benyumov A; Hergert P; Tank D; Herrera J; Braziunas J; Larsson O; Parker M; Rossi D; Smith K; Peterson M; Limper A; Jessurun J; Connett J; Ingbar D; Sem P; Bitterman PB; Henke CA
- Article: JOURNAL OF THORACIC ONCOLOGY. 2014;9(5):639-645Hohberger LA; Schroeder DR; Bartholmai BJ; Yang P; Wendt CH; Bitterman PB; Larsson O; Limper AH
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(4):1622-1635Parker MW; Rossi D; Peterson M; Smith K; Sikstrom K; White ES; Connett JE; Henke CA; Larsson O; Bitterman PB
- Article: PROSTATE. 2013;73(16):1810-1823Wilkinson SE; Furic L; Buchanan G; Larsson O; Pedersen J; Frydenberg M; Risbridger GP; Taylor RA
- Article: CELL METABOLISM. 2013;18(5):698-711Morita M; Gravel S-P; Chenard V; Sikstrom K; Zheng L; Alain T; Gandin V; Avizonis D; Arguello M; Zakaria C; McLaughlan S; Nouet Y; Pause A; Pollak M; Gottlieb E; Larsson O; St-Pierre J; Topisirovic I; Sonenberg N
- Article: PLOS GENETICS. 2013;9(5):e1003494Bjur E; Larsson O; Yurchenko E; Zheng L; Gandin V; Topisirovic I; Li S; Wagner CR; Sonenberg N; Piccirillo CA
- Article: BLOOD. 2013;121(17):3402-3412Mills JR; Malina A; Lee T; Di Paola D; Larsson O; Miething C; Grosse F; Tang H; Zannis-Hadjopoulos M; Lowe SW; Pelletier J
- Article: TRANSLATION. 2013;1(1):e24557Larsson O; Nadon R
- Article: NATURE COMMUNICATIONS. 2013;4:2129Hosaka K; Yang Y; Seki T; Nakamura M; Andersson P; Rouhi P; Yang X; Jensen L; Lim S; Feng N; Xue Y; Li X; Larsson O; Ohhashi T; Cao Y
- Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2013;5(1):a012302Larsson O; Tian B; Sonenberg N
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2012;32(17):3585-3593Morita M; Ler LW; Fabian MR; Siddiqui N; Mullin M; Henderson VC; Alain T; Fonseca BD; Karashchuk G; Bennett CF; Kabuta T; Higashi S; Larsson O; Topisirovic I; Smith RJ; Gingras A-C; Sonenberg N
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(24):9551-9556Edlund K; Larsson O; Ameur A; Bunikis I; Gyllensten U; Leroy B; Sundstrom M; Micke P; Botling J; Soussi T
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(23):8977-8982Larsson O; Morita M; Topisirovic I; Alain T; Blouin M-J; Pollak M; Sonenberg N
- Article: NATURE MEDICINE. 2011;18(1):100-110Xue Y; Lim S; Yang Y; Wang Z; Jensen LDE; Hedlund E-M; Andersson P; Sasahara M; Larsson O; Galter D; Gao R; Hosaka K; Cao Y
- Article: BIOINFORMATICS. 2011;27(10):1440-1441Larsson O; Sonenberg N; Nadon R
- Article: CELL HOST & MICROBE. 2011;9(4):331-341Jaramillo M; Gomez MA; Larsson O; Shio MT; Topisirovic I; Contreras I; Luxenburg R; Rosenfeld A; Colina R; McMaster RW; Olivier M; Costa-Mattioli M; Sonenberg N
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(50):21487-21492Larsson O; Sonenberg N; Nadon R
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(32):14134-14139Furic L; Rong L; Larsson O; Koumakpayi IH; Yoshida K; Brueschke A; Petroulakis E; Robichaud N; Pollak M; Gaboury LA; Pandolfi PP; Saad F; Sonenberg N
- Article: SCIENCE. 2010;328(5982):1172-1176Dowling RJO; Topisirovic I; Alain T; Bidinosti M; Fonseca BD; Petroulakis E; Wang X; Larsson O; Selvaraj A; Liu Y; Kozma SC; Thomas G; Sonenberg N
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(52):22217-22222Parsyan A; Shahbazian D; Martineau Y; Petroulakis E; Alain T; Larsson O; Mathonnet G; Tettweiler G; Hellen CU; Pestova TV; Svitkin YV; Sonenberg N
- Article: CHEMISTRY AND BIOLOGY. 2009;16(12):1240-1249Livingstone M; Larsson O; Sukarieh R; Pelletier J; Sonenberg N
- Article: CANCER CELL. 2009;16(5):439-446Petroulakis E; Parsyan A; Dowling RJO; LeBacquer O; Martineau Y; Bidinosti M; Larsson O; Alain T; Rong L; Mamane Y; Paquet M; Furic L; Topisirovic I; Shahbazian D; Livingstone M; Costa-Mattioli M; Teodoro JG; Sonenberg N
- Article: CANCER RESEARCH. 2009;69(21):8455-8462Kim YY; Von Weymarn L; Larsson O; Fan D; Underwood JM; Peterson MS; Hecht SS; Polunovsky VA; Bitterman PB
- Article: RNA. 2009;15(8):1469-1482Fan D; Bitterman PB; Larsson O
- Article: PLOS ONE. 2009;4(3):e4868Santhanam AN; Bindewald E; Rajasekhar VK; Larsson O; Sonenberg N; Colburn NH; Shapiro BA
- Article: CELL METABOLISM. 2009;9(1):99-109Xue Y; Petrovic N; Cao R; Larsson O; Lim S; Chen S; Feldmann HM; Liang Z; Zhu Z; Nedergaard J; Cannon B; Cao Y
- Article: PROSTATE. 2009;69(1):33-40Cox ME; Gleave ME; Zakikhani M; Bell RH; Piura E; Vickers E; Cunningham M; Larsson O; Fazli L; Pollak M
- Article: PLOS ONE. 2008;3(9):e3220Larsson O; Diebold D; Fan D; Peterson M; Nho RS; Bitterman PB; Henke CA
- Article: NATURE. 2008;452(7185):323-328Colina R; Costa-Mattioli M; Dowling RJO; Jaramillo M; Tai L-H; Breitbach CJ; Martineau Y; Larsson O; Rong L; Svitkin YV; Makrigiannis AP; Bell JC; Sonenberg N
- Article: MOLECULAR CELL. 2008;29(2):263-270Vlasova IA; Tahoe NM; Fan D; Larsson O; Rattenbacher B; John JRS; Vasdewani J; Karypis G; Reilly CS; Bitterman PB; Bohjanen PR
- Article: FASEB JOURNAL. 2007;21(13):3653-3665Scheele C; Nielsen AR; Walden TB; Sewell DA; Fischer CP; Brogan RJ; Petrovic N; Larsson O; Tesch PA; Wennmalm K; Hutchinson DS; Cannon B; Wahlestedt C; Pedersen BK; Timmons JA
- Article: CANCER RESEARCH. 2007;67(14):6814-6824Larsson O; Li S; Issaenko OA; Avdulov S; Peterson M; Smith K; Bitterman PB; Polunovsky VA
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(11):4401-4406Timmons JA; Wennmalm K; Larsson O; Walden TB; Lassmann T; Petrovic N; Hamilton DL; Gimeno RE; Wahlestedt C; Baar K; Nedergaard J; Cannon B
- Article: PLOS ONE. 2007;2(2):e242Mamane Y; Petroulakis E; Martineau Y; Sato T-A; Larsson O; Rajasekhar VK; Sonenberg N
- Article: BMC BIOINFORMATICS. 2007;8:48Sandberg R; Larsson O
- Journal article: NATURE BIOTECHNOLOGY. 2006;24(11):1322-1323Larsson O; Sandberg R
- Article: NUCLEIC ACIDS RESEARCH. 2006;34(16):4375-4386Larsson O; Perlman DM; Fan D; Reilly CS; Peterson M; Dahlgren C; Liang Z; Li S; Polunovsky VA; Wahlestedt C; Bitterman PB
- Article: OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY. 2006;10(3):381-397Larsson O; Wennmalm K; Sandberg R
- Journal article: BMC BIOINFORMATICS. 2005;6:129Larsson O; Wahlestedt C; Timmons JA
- Article: FASEB JOURNAL. 2005;19(7):750-760Timmons JA; Larsson O; Jansson E; Fischer H; Gustafsson T; Greenhaff PL; Ridden P; Rachman J; Peyrard-Janvid M; Wahlestedt C; Sundberg CJ
- Article: GENOME BIOLOGY. 2005;6(13):R109Wennmalm K; Wahlestedt C; Larsson O
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;316(3):680-687Xu YH; Linde A; Larsson A; Thormeyer D; Elmen J; Wahlestedt C; Liang ZC
- Article: CANCER RESEARCH. 2004;64(2):482-489Larsson O; Scheele C; Liang ZC; Moll J; Karlsson C; Wahlestedt C
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;306(3):712-717Xu YH; Zhang HY; Thormeyer D; Larsson A; Du Q; Elmén J; Wahlestedt C; Liang Z
- Article: BIOTECHNIQUES. 2003;34(2):346-355Thormeyer D; Ammerpohl O; Larsson O; Xu Y; Asinger A; Wahlestedt C; Liang Z
- Article: NUCLEIC ACIDS RESEARCH. 2002;30(23):e133Larsson O; Thormeyer D; Asinger A; Wihlén B; Wahlestedt C; Liang Z
- Article: NATURE BIOTECHNOLOGY. 2001;19(4):360-364Good L; Awasthi SK; Dryselius R; Larsson O; Nielsen PE
- Article: MICROBIOLOGY-SGM. 2000;146:2665-2670Good L; Sandberg R; Larsson O; Nielsen PE; Wahlestedt C
- Article: NUCLEIC ACIDS RESEARCH. 2000;28(14):E71Kumar A; Larsson O; Parodi D; Liang Z
- Show more
All other publications
- Review: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2025;32(3):418-430Loughran G; Andreev DE; Terenin IM; Namy O; Mikl M; Yordanova MM; Mcmanus CJ; Firth AE; Atkins JF; Fraser CS; Ignatova Z; Iwasaki S; Kufel J; Larsson O; Leidel SA; Mankin AS; Mariotti M; Tanenbaum ME; Topisirovic I; Vazquez-Laslop N; Viero G; Caliskan N; Chen Y; Clark PL; Dinman JD; Farabaugh PJ; Gilbert WV; Ivanov P; Kieft JS; Muhlemann O; Sachs MS; Shatsky IN; Sonenberg N; Steckelberg A-L; Willis AE; Woodside MT; Valasek LS; Dmitriev SE; Baranov PV
- Preprint: BIORXIV. 2024;BIORXIVMartin P; Szkop KJ; Robert F; Bhattacharyya S; Beauchamp RL; Brenner J; Redmond NE; Huang S; Erdin S; Larsson O; Ramesh V
- Preprint: BIORXIV. 2023Watt K; Dauber B; Szkop K; Lee L; Jovanovic P; Chen S; Palia R; Vassalakis J; Cooper T; Papadopoli D; Masvidal L; Jewer M; Tandoc K; Plummer H; Lajoie G; Topisirovic I; Larsson O; Postovit L-M
- Review: NATURE REVIEWS CANCER. 2023;23(6):408-425Bartish M; Abraham MJ; Goncalves C; Larsson O; Rolny C; Del Rincon SV
- Preprint: RES SQ. 2023;RES SQAksoylu IS; Martin P; Robert F; Szkop KJ; Redmond NE; Chen S; Beauchamp RL; Nobeli I; Pelletier J; Larsson O; Ramesh V
- Preprint: BIORXIV. 2023Li Q; Vetter L; Veith Y; Christ E; Végvári Á; Sahin C; Ribacke U; Wahlgren M; Ankarklev J; Larsson O; Chan SC-L
- Review: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2022;1869(1):119140Kusnadi EP; Timpone C; Topisirovic I; Larsson O; Furic L
- Preprint: BIORXIV. 2021Rendleman J; Haizel S; Wu S; Liu J; Ge X; Zou H; Mohammad MP; Pressler M; Maity S; Hronová V; Gao Z; Herrmannová A; Lei A; Allgoewer K; Sultanov D; Hinckley WE; Cheng Z; Shelby L; Szkop K; Topisirovic I; Larsson O; Hatzoglou M; Valášek LS; Vogel C
- Conference publication: EUROPEAN JOURNAL OF CANCER. 2020;138:S23Ghaddar N; Wang S; Woodvine B; Krishnamoorthy J; Darini C; Van Hoef V; Popper H; Topisirovic I; Larsson O; Le Quesne J; Koromilas A
- Review: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. 2017;1868(2):484-499Ramon y Cajal S; Capdevila C; Hernandez-Losa J; De Mattos-Arruda L; Ghosh A; Lorent J; Larsson O; Aasen T; Postovit L-M; Topisirovic I
- Review: NATURE IMMUNOLOGY. 2014;15(6):503-511Piccirillo CA; Bjur E; Topisirovic I; Sonenberg N; Larsson O
- Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2009;457:211-229Scheele C; Larsson O; Timmons JA
- Review: BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS. 2008;25:77-92Larsson O; Nadon R
- Review: TOPICS IN CURRENT CHEMISTRY. 2005;261:45-61Du Q; Larsson O; Swerdlow H; Liang Z
Grants
- Swedish Research Council1 January 2022 - 31 December 2025Plasmodium falciparum is a parasite that causes human malaria which remains one of the most important infectious diseases worldwide. Managing this global emergency will require a deeper understanding of the resistance mechanisms developed by the parasite to survive in the presence of artemisnins, as well as opening up new therapeutic avenues. As of recently, mounting evidence converges to suggest a strong tie between the phenotypic characteristics of artemisinin resistance to general cellular stress response mechanisms. In this project proposal, we suggest to conduct a comprehensive investigation on the systemicregulation of translation during stress responses in the parasite P. falciparum. We will approach this by first establishing a deeper understanding of the ribosome and the tRNA biology in the parasite with the use of various molecular assays and subsequently decipher how the regulation of two abundant ncRNA classes may affect the translatome and the functional proteome output during stress conditions. Together with the preliminary data we have already obtained, this project aims to achieve the followings:1. To characterize a novel and universally conserved ribosome associated factor in P.falciparum and its role in stress responses.2. To provide supporting evidence for the presence of functionally specializedribosomes.3. To identify common stress response pathways through studying the tRNAepitranscriptome.4. To develop a high-throughput drug screening assay.
- Examining the MNK1/2-eIF4E axis in cancer associated fibroblasts as a driver of oncogenic progressionCanadian Cancer Society1 May 2021 - 30 April 2026In spite of some exciting advances in the treatment of breast cancer, a diagnosis of metastasis still remains deadly in many. Existing therapies often fail in women with metastatic breast cancer, and oncologists sadly inform their patients that there are no further treatment options. We need a new way to block metastasis. Based on the data we have acquired, we propose that blocking faulty protein synthesis in cancer associated fibroblasts, using drugs that block MNK1/2, will inhibit metastasis. The goal of our research is to better understand the biology of MNK1/2 and how their activation promotes metastasis. The activity of MNK1/2 in cancer associated fibroblasts (CAF), which are metastasis promoting cells, remains unknown. We will clarify this using mouse models and breast tumors from women being treated with MNK1/2 inhibitors in our clinical trial. Ultimately, we seek to identify biomarkers to predict response to MNK1/2 inhibitors, which may include CAF-specific proteins. Our project brings together experts in oncology, translational control, proteomics, and MNK1/2 biology, all dedicated to the success of the proposed work. We will use in vitro/in vivo metastasis models. A unique advantage of our project is that we have access to tumors from women with metastatic breast cancer, who are being treated with MNK1/2 inhibitors in our clinical trial. The samples will be imaged to provide an unprecedented view of the impacts of MNK1/2 inhibition to the tumor landscape. Metastasis remains the leading cause of breast cancer related deaths. MNK1/2 inhibitors are currently in clinical trials for the treatment of cancer, including at our institution. Importantly, we propose that MNK1/2 inhibitors will be most effective for treating metastasis. If we are correct, we would be impacting not only the 20-30% of patients diagnosed with breast cancer who will develop metastasis, but also their families. We will work with the Quebec Breast Cancer Foundation (see letter) to communicate our research results to the public, as we have done in the past. Our project provides hope to women with metastatic breast cancer.
- Swedish Research Council1 December 2020 - 31 December 2022
- Targeting mRNA translation to reverse resistance to endocrine therapySwedish Cancer Society1 January 2019A majority of all women who die as a result of breast cancer belong to a category of breast cancer that expresses the estrogen receptor. This is because most breast cancer patients belong to that category and because resistance to treatment focuses on inhibition of the estrogen receptor, so-called endocrine therapy, continues to occur for at least 20 years after the cancer has been removed. There is currently a lack of effective treatments for breast cancer that have developed resistance to endocrine therapy and it is therefore of utmost importance to find molecular targets that can be used to treat these patients. When genes are expressed, a copy (mRNA) is first made which is used to produce proteins via so-called translation. The estrogen receptor is a key factor for which genes to copy. We have recently discovered that the estrogen receptor also affects which of these mRNAs are translated into proteins. Our preliminary data show that if the estrogen receptor can not affect the translation of mRNA into proteins, it can also not affect cell division, which is one of its key functions in cancer cells. It also seems that if you inhibit the translation that is regulated by the estrogen receptor, you can make cancer cells again sensitive to endocrine treatment. We want to clarify whether translation of mRNA can be used as a target for the treatment of breast cancer with resistance to endocrine therapy. We also want to study, using tissue samples from original breast tumors and their metastases, whether up-regulation of mRNA translation is associated with metastasis. Furthermore, by comparing patients with short and long time to recurrence, we will investigate whether misregulation of mRNA translation is associated with cancer recurrence. Through these studies, we will understand whether translation of mRNA is a target for the treatment of breast cancer that has developed resistance to endocrine therapy.
- National Health and Medical Research Council1 January 2018 - 31 December 2020
- Swedish Research Council1 January 2017 - 31 December 2020
- Swedish Research Council1 January 2014 - 31 December 2016
- Swedish Research Council1 January 2010 - 31 December 2013
- Swedish Research Council1 January 2010 - 31 December 2013
Employments
- Principal Researcher, Department of Oncology-Pathology, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2016
- Doctor Of Philosophy, Research Center for Genomics, Karolinska Institutet, 2005
- Master Of Medical Science, Karolinska Institutet, 2000
Leadership and responsibility assignments
- Head of department, Department of Oncology-Pathology, Karolinska Institutet, 2025-