Ning Xu Landén

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Docent i experimentell dermatologi och venereologi, 2017. Det finns mer
information som presenteras på sidan på engelska och
på http://www.xulandenlab.com [1]
[1] http://www.xulandenlab.com

Forskningsbeskrivning

Både kroniska svårläkta sår och psoriasis är utbredda sjukdomar som
medför stegrande hälso- och ekonomiska bördor över hela världen i brist
på effektiv behandling. Undersökning av rollen av regulatoriska RNA, till
exempel mikroRNA och långa icke-kodande RNA, utgör ett växande koncept och
ett lovande område för farmaceutiskt ingrepp. Målet för vårt
laboratorium är att fastställa hur regulatoriska RNA påverkar huden vid
sårläkning och vid psoriasis. Dessutom strävar vi efter att tillämpa
grundläggande vetenskapliga fynd som terapeutiska ingrepp för patienter.

Artiklar

Article: NATURE COMMUNICATIONS. 2024;15(1):9286
Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors
Bian X; Piipponen M; Liu Z; Luo L; Geara J; Chen Y; Sangsuwan T; Maselli M; Diaz C; Bain CA; Eenjes E; Genander M; Crichton M; Cash JL; Archambault L; Haghdoost S; Fradette J; Sommar P; Halle M; Landen NX
Journal article: NATURE COMMUNICATIONS. 2024;15(1):8637
The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healing.
Li D; Liu Z; Zhang L; Bian X; Wu J; Li L; Chen Y; Luo L; Pan L; Kong L; Xiao Y; Wang J; Zhang X; Wang W; Toma M; Piipponen M; Sommar P; Xu Landén N
Article: FRONTIERS IN SURGERY. 2024;11:1349135
Single-cell profiling and functional screening reveal crucial roles for lncRNAs in the epidermal re-epithelialization of human acute wounds
Xiao Y; Zhang C; Liu X; Yang Y; Landen NX; Zhang Z; Li D
Article: CELL DEATH AND DIFFERENTIATION. 2023;30(5):1334-1348
Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport
Zhang L; Piipponen M; Liu Z; Li D; Bian X; Niu G; Geara J; Toma MA; Sommar P; Landen NX
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(10):2793-2804.e26
Circular RNA Signatures of Human Healing and Nonhealing Wounds
Toma MA; Liu Z; Wang Q; Zhang L; Li D; Sommar P; Landen NX
Article: ELIFE. 2022;11:e80322
Integrative small and long RNA omics analysis of human healing and nonhealing wounds discovers cooperating microRNAs as therapeutic targets
Liu Z; Zhang L; Toma MA; Li D; Bian X; Pastar I; Tomic-Canic M; Sommar P; Xu Landen N
Article: SCIENCE. 2022;377(6602):eabg9302
Interleukin-17 governs hypoxic adaptation of injured epithelium
Konieczny P; Xing Y; Sidhu I; Subudhi I; Mansfield KP; Hsieh B; Biancur DE; Larsen SB; Cammer M; Li D; Landen NX; Loomis C; Heguy A; Tikhonova AN; Tsirigos A; Naik S
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(3 PT A):705-716
Single-Cell Analysis Reveals Major Histocompatibility Complex II-Expressing Keratinocytes in Pressure Ulcers with Worse Healing Outcomes
Li D; Cheng S; Pei Y; Sommar P; Karner J; Herter EK; Toma MA; Zhang L; Pham K; Cheung YT; Liu Z; Chen X; Eidsmo L; Deng Q; Landen NX
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2022;14(9):a041230
Beyond the Code: Noncoding RNAs in Skin Wound Healing
Li D; Niu G; Landen NX
Article: CLINICAL EPIGENETICS. 2021;13(1):161
DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A₂ in human vulnerable atherosclerotic plaque
Li J; Zhang X; Yang M; Yang H; Xu N; Fan X; Liu G; Jiang X; Fan J; Zhang L; Zhang H; Zhou Y; Li R; Gao S; Jin J; Jin Z; Zheng J; Tu Q; Ren J
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(3):659-671
miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes
Li D; Peng H; Qu L; Sommar P; Wang A; Chu T; Li X; Bi X; Liu Q; Serezal IG; Rollman O; Lohcharoenkal W; Zheng X; Angelstig SE; Grunler J; Pivarcsi A; Sonkoly E; Catrina S-B; Xiao C; Stahle M; Mi Q-S; Zhou L; Landen NX
Article: METHODS IN MOLECULAR BIOLOGY. 2021;2193:67-75
Evaluation of MicroRNA Therapeutic Potential Using the Mouse In Vivo and Human Ex Vivo Wound Models.
Li X; Xu Landén N
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):768
HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism
Narayanan S; Angelstig SE; Xu C; Grunler J; Zhao A; Zhu W; Landen NX; Stahle M; Zhang J; Ivan M; Maltesen RG; Botusan IR; Ekberg NR; Zheng X; Catrina S-B
Article: ADVANCES IN WOUND CARE. 2020;9(4):145-160
Circular RNA hsa_circ_0084443 Is Upregulated in Diabetic Foot Ulcer and Modulates Keratinocyte Migration and Proliferation
Wang A; Toma MA; Ma J; Li D; Vij M; Chu T; Wang J; Li X; Landen NX
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2020;140(2):465-476.e11
MicroRNA-34 Family Enhances Wound Inflammation by Targeting LGR4
Wu J; Li X; Li D; Ren X; Li Y; Herter EK; Qian M; Toma M-A; Wintler A-M; Serezal IG; Rollman O; Stahle M; Wikstrom JD; Ye X; Landen NX
Article: METHODS IN MOLECULAR BIOLOGY. 2020;2154:239-247
Investigation of Skin Wound Healing Using a Mouse Model.
Wu J; Landén NX
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(6):1373-1384
WAKMAR2, a Long Noncoding RNA Downregulated in Human Chronic Wounds, Modulates Keratinocyte Motility and Production of Inflammatory Chemokines
Herter EK; Li D; Toma MA; Vij M; Li X; Visscher D; Wang A; Chu T; Sommar P; Blomqvist L; Berglund D; Stahle M; Wikstrom JD; Landen NX
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(19):9443-9452
Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration
Li D; Kular L; Vij M; Herter EK; Li X; Wang A; Chu T; Toma M-A; Zhang L; Liapi E; Mota A; Blomqvist L; Serezal IG; Rollman O; Wikstrom JD; Bienko M; Berglund D; Stahle M; Sommar P; Jagodic M; Landen NX
Article: ACTA DERMATO-VENEREOLOGICA. 2019;99(2):196-205
The Keratinocyte Transcriptome in Psoriasis: Pathways Related to Immune Responses, Cell Cycle and Keratinization
Pasquali L; Srivastava A; Meisgen F; Das Mahapatra K; Xia P; Landen NX; Pivarcsi A; Sonkoly E
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(8):1754-1763
Resident T Cells in Resolved Psoriasis Steer Tissue Responses that Stratify Clinical Outcome
Serezal IG; Classon C; Cheuk S; Barrientos-Somarribas M; Wadman E; Martini E; Chang D; Landen NX; Ehrstrom M; Nylen S; Eidsmo L
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(4):882-892
Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis
Lohcharoenkal W; Das Mahapatra K; Pasquali L; Crudden C; Kular L; Ulum YZA; Zhang L; Landen NX; Girnita L; Jagodic M; Stahle M; Sonkoly E; Pivarcsi A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(12):2630-2638
MicroRNA-132 with Therapeutic Potential in Chronic Wounds
Li X; Li D; Wang A; Chu T; Lohcharoenkal W; Zheng X; Grunler J; Narayanan S; Eliasson S; Herter EK; Wang Y; Ma Y; Ehrstrom M; Eidsmo L; Kasper M; Pivarcsi A; Sonkoly E; Catrina S-B; Stahle M; Landen NX
Article: SCIENTIFIC REPORTS. 2017;7(1):7797
MicroRNA-132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing
Li X; Li D; Wikstrom JD; Pivarcsi A; Sonkoly E; Stahle M; Landen NX
Article: BRITISH JOURNAL OF DERMATOLOGY. 2017;176(3):723-731
Ubiquitin-specific peptidase 2 as a potential link between microRNA-125b and psoriasis
Wei T; Folkersen L; Biskup E; Xu N; Manfe V; Niazi O; Gniadecki R
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(2):550-561
MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis
Srivastava A; Nikamo P; Lohcharoenkal W; Li D; Meisgen F; Landen NX; Stahle M; Pivarcsi A; Sonkoly E
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016;19(12):pyw069
MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro
Bin Wei Y; Melas PA; Villaescusa JC; Liu JJ; Xu N; Christiansen SH; Elbrond-Bek H; Woldbye DPD; Wegener G; Mathe AA; Lavebratt C
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(12):2485-2494
MicroRNA-203 Inversely Correlates with Differentiation Grade, Targets c-MYC, and Functions as a Tumor Suppressor in cSCC
Lohcharoenkal W; Harada M; Loven J; Meisgen F; Landen NX; Zhang L; Lapins J; Das Mahapatra K; Shi H; Nissinen L; Kahari V-M; Stahle M; Sonkoly E; Grander D; Arsenian-Henriksson M; Pivarcsi A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(3):640-648
Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue
Cheung L; Fisher RM; Kuzmina N; Li D; Li X; Werngren O; Blomqvist L; Stahle M; Landen NX
Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(8):3008-3026
MicroRNA-132 enhances transition from inflammation to proliferation during wound healing
Li D; Wang A; Liu X; Meisgen F; Gruenler J; Botusan IR; Narayanan S; Erikci E; Li X; Blomqvist L; Du L; Pivarcsi A; Sonkoly E; Chowdhury K; Catrina S-B; Stahle M; Landen NX
Article: SCIENTIFIC REPORTS. 2015;5:12017
Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment
Checa A; Xu N; Sar DG; Haeggstrom JZ; Stahle M; Wheelock CE
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2015;135(6):1676-1685
MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration
Li D; Li X; Wang A; Meisgen F; Pivarcsi A; Sonkoly E; Stahle M; Landen NX
Article: BMC MEDICAL GENOMICS. 2015;8:12
Effects of statin on circulating microRNAome and predicted function regulatory network in patients with unstable anginad
Li J; Chen H; Ren J; Song J; Zhang F; Zhang J; Lee C; Li S; Geng Q; Cao C; Xu N
Article: JOURNAL OF PROTEOME RESEARCH. 2015;14(1):557-566
LC-MS Metabolomics of Psoriasis Patients Reveals Disease Severity-Dependent Increases in Circulating Amino Acids That Are Ameliorated by Anti-TNFα Treatment
Kamleh MA; Snowden SG; Grapov D; Blackburn GJ; Watson DG; Xu N; Stahle M; Wheelock CE
Article: ATHEROSCLEROSIS. 2014;237(2):514-520
MicroRNA-223 inhibits tissue factor expression in vascular endothelial cells
Li S; Chen H; Ren J; Geng Q; Song J; Lee C; Cao C; Zhang J; Xu N
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2014;75:49-57
MicroRNA-19b functions as potential anti-thrombotic protector in patients with unstable angina by targeting tissue factor
Li S; Ren J; Xu N; Zhang J; Geng Q; Cao C; Lee C; Song J; Li J; Chen H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(7):1931-1940
MiR-146a Negatively Regulates TLR2-Induced Inflammatory Responses in Keratinocytes
Meisgen F; Landen NX; Wang A; Rethi B; Bouez C; Zuccolo M; Gueniche A; Stahle M; Sonkoly E; Breton L; Pivarcsi A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(6):1535-1541
Genetic Variants of the IL22 Promoter Associate to Onset of Psoriasis before Puberty and Increased IL-22 Production in T Cells
Nikamo P; Cheuk S; Lysell J; Enerback C; Bergh K; Landen NX; Eidsmo L; Stahle M
Article: CARCINOGENESIS. 2014;35(5):1110-1120
miR-193b/365a cluster controls progression of epidermal squamous cell carcinoma
Gastaldi C; Bertero T; Xu N; Bourget-Ponzio I; Lebrigand K; Fourre S; Popa A; Cardot-Leccia N; Meneguzzi G; Sonkoly E; Pivarcsi A; Mari B; Barbry P; Ponzio G; Rezzonico R
Article: EXPERIMENTAL DERMATOLOGY. 2014;23(4):281-283
Activation of Toll-like receptors alters the microRNA expression profile of keratinocytes
Meisgen F; Landen NX; Bouez C; Zuccolo M; Gueniche A; Stahle M; Sonkoly E; Breton L; Pivarcsi A
Article: PLOS ONE. 2014;9(1):e87826
Therapeutic Effect of Intravenous Infusion of Perfluorocarbon Emulsion on LPS-Induced Acute Lung Injury in Rats
Hou S; Ding H; Lv Q; Yin X; Song J; Landen NX; Fan H
Article: PLOS ONE. 2014;9(7):e103206
MicroRNA-31 Is Overexpressed in Cutaneous Squamous Cell Carcinoma and Regulates Cell Motility and Colony Formation Ability of Tumor Cells
Wang A; Landen NX; Meisgen F; Lohcharoenkal W; Stahle M; Sonkoly E; Pivarcsi A
Article: BRITISH JOURNAL OF DERMATOLOGY. 2013;169(3):563-570
Changes in the level of serum microRNAs in patients with psoriasis after antitumour necrosis factor- therapy
Pivarcsi A; Meisgen F; Xu N; Stahle M; Sonkoly E
Article: JOURNAL OF IMMUNOLOGY. 2013;190(2):678-688
MicroRNA-31 Is Overexpressed in Psoriasis and Modulates Inflammatory Cytokine and Chemokine Production in Keratinocytes via Targeting Serine/Threonine Kinase 40
Xu N; Meisgen F; Butler LM; Han G; Wang X-J; Soderberg-Naucler C; Stahle M; Pivarcsi A; Sonkoly E
Article: PLOS ONE. 2013;8(12):e80738
Signature of Circulating MicroRNAs as Potential Biomarkers in Vulnerable Coronary Artery Disease
Ren J; Zhang J; Xu N; Han G; Geng Q; Song J; Li S; Zhao J; Chen H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(35):29899-29908
MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration, and Invasion
Xu N; Zhang L; Meisgen F; Harada M; Heilborn J; Homey B; Grander D; Stahle M; Sonkoly E; Pivarcsi A
Article: EXPERIMENTAL DERMATOLOGY. 2012;21(4):312-314
MiR-21 is uip-regulated n psoriasis and suppresses T cell apoptosis
Meisgen F; Xu N; Wei T; Janson PC; Obad S; Broom O; Nagy N; Kauppinen S; Kemeny L; Stahle M; Pivarcsi A; Sonkoly E
Article: ONCOGENESIS. 2012;1(3):e3
MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma
Sonkoly E; Loven J; Xu N; Meisgen F; Wei T; Brodin P; Jaks V; Kasper M; Shimokawa T; Harada M; Heilborn J; Hedblad M-A; Hippe A; Grander D; Homey B; Zaphiropoulos PG; Arsenian-Henriksson M; Stahle M; Pivarcsi A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(7):1521-1529
MiR-125b, a MicroRNA Downregulated in Psoriasis, Modulates Keratinocyte Proliferation by Targeting FGFR2
Xu N; Brodin P; Wei T; Meisgen F; Eidsmo L; Nagy N; Kemeny L; Stahle M; Sonkoly E; Pivarcsi A
Article: METHODS IN MOLECULAR BIOLOGY. 2011;721:183-198
Characterization of RISC-associated adenoviral small RNAs.
Xu N; Akusjärvi G
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;126(3):581-9.e1-20-U306
MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4
Sonkoly E; Janson P; Majuri M-L; Savinko T; Fyhrquist N; Eidsmo L; Xu N; Meisgen F; Wei T; Bradley M; Stenvang J; Kauppinen S; Alenius H; Lauerma A; Homey B; Winqvist O; Stahle M; Pivarcsi A
Article: NUCLEIC ACIDS RESEARCH (NAR). 2009;37(20):6950-6959
The 5'-end heterogeneity of adenovirus virus-associated RNAI contributes to the asymmetric guide strand incorporation into the RNA-induced silencing complex
Xu N; Gkountela S; Saeed K; Akusjarvi G
Article: JOURNAL OF VIROLOGY. 2007;81(19):10540-10549
Adenovirus virus-associated RNAII-Derived small RNAs are efficiently incorporated into the RNA-Induced silencing complex and associate with polyribosomes
Xu N; Segerman B; Zhou X; Akusjarvi G
Article: METHODS IN MOLECULAR MEDICINE. 2007;131:47-61
In vitro methods to study RNA interference during an adenovirus infection.
Andersson G; Xu N; Akusjärvi G
Article: JOURNAL OF VIROLOGY. 2005;79(15):9556-9565
Suppression of RNA interference by adenovirus virus-associated RNA
Andersson MG; Haasnoot PCJ; Xu N; Berenjian S; Berkhout B; Akusjärvi G
Visa fler

Alla övriga publikationer

Review: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(9):1667-1677
A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization
Almet AA; Yuan H; Annusver K; Ramos R; Liu Y; Wiedemann J; Sorkin DH; Landen NX; Sonkoly E; Haniffa M; Nie Q; Lichtenberger BM; Luecken MD; Andersen B; Tsoi LC; Watt FM; Gudjonsson JE; Plikus MV; Kasper M
Review: HEALTH SCIENCE REPORTS. 2021;4(4):e374
Targeting microRNA for improved skin health
Li X; Ponandai-Srinivasan S; Nandakumar KS; Fabre S; Landen NX; Mavon A; Khmaladze I
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(22):E8790-8790
The Immune Functions of Keratinocytes in Skin Wound Healing
Piipponen M; Li D; Landen NX
Letter: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(12):2547-2550.e12
Next-Generation Sequencing Identifies the Keratinocyte-Specific miRNA Signature of Psoriasis
Srivastava A; Meisgen F; Pasquali L; Munkhammar S; Xia P; Stahle M; Landen NX; Pivarcsi A; Sonkoly E
Review: EUROPEAN JOURNAL OF DERMATOLOGY. 2017;27(S1):12-14
MicroRNAs in skin wound healing
Li D; Landen NX
Review: ADVANCES IN WOUND CARE. 2017;6(3):93-107
Non-Coding RNAs: New Players in Skin Wound Healing
Herter EK; Landen NX
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2016;73(20):3861-3885
Transition from inflammation to proliferation: a critical step during wound healing
Landen NX; Li D; Stahle M
Review: IUBMB LIFE. 2015;67(8):601-610
New insights into T cells and their signature cytokines in atopic dermatitis
Wang A-X; Landen NX
Letter: ACTA DERMATO-VENEREOLOGICA. 2013;93(3):366-367
Are BIC (miR-155) Polymorphisms Associated with Eczema Susceptibility?
Saaf A; Kockum I; Wahlgren C-F; Xu N; Sonkoly E; Stahle M; Nordenskjold M; Bradley M; Pivarcsi A
Published conference paper: EUROPEAN JOURNAL OF DERMATOLOGY. 2013;23:66-71
Interleukin-8 is regulated by miR-203 at the posttranscriptional level in primary human keratinocytes
Wei T; Xu N; Meisgen F; Stahle M; Sonkoly E; Pivarcsi A
Review: YI CHUAN = HEREDITAS / ZHONGGUO YI CHUAN XUE HUI BIAN JI. 2012;34(6):784-792
[Application of next generation sequencing in microRNA detection].
Tang H-M; Chen H; Zhang J; Ren J-Y; Xu N
Letter: EXPERIMENTAL DERMATOLOGY. 2010;19(9):854-856
The expression of microRNA-203 during human skin morphogenesis
Wei T; Orfanidis K; Xu N; Janson P; Stahle M; Pivarcsi A; Sonkoly E

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