Mikael Ryden
Professor/Överläkare | Docent
E-postadress: mikael.ryden@ki.se
Telefon: +46852482922
Besöksadress: C2:94, Karolinska Universitetssjukhuset Huddinge, 14186 Stockholm
Postadress: H7 Medicin, Huddinge, H7 Endokrinologi och diabetes Rydén&Mejhert, 171 77 Stockholm
Om mig
- Professor i klinisk och experimentell fettvävsforskning, samt chef för Avdelningen för endokrinologi med Lipidlaboratoriet och Patientforskningscentrum vid institutionen för medicin i Huddinge.
Mikael Rydén föddes 1970 i Stockholm, tog läkarexamen 1996 och disputerade 1997. Parallellt med studierna på Karolinska Institutet bedrev han forskarstudier i molekylär neurobiologi. Han fortsatte forska kring intracellulära signalvägar i humana fettceller och deras relevans för utveckling av insulinresistens och typ 2-diabetes.
Han blev 2002 docent i experimentell endokrinologi och 2006 i endokrinologi. Han tilldelades 2003 Young Investigators Award in Basic Science från European Association on the Study of Obesity och innehade 2003-2009 en halvtidstjänst för forskande kliniker. Han blev 2005 specialist i internmedicin och 2006 i endokrinologi/diabetologi.
Han blev 2010 universitetslektor och överläkare vid kliniken för endokrinologi, metabolism och diabetes, Karolinska universitetssjukhuset Huddinge, och är sedan 2010 ansvarig för Kliniskt centrum för metabol forskning på diabetes inom KI:s diabetesprogram.
Akademiska priser och utmärkelser
Mikael Rydén utnämndes den 1 juli 2013 till professor i klinisk och experimentell fettvävsforskning vid Karolinska Institutet, förenad med befattning som specialistkompetent läkare vid Karolinska universitetssjukhuset.
Forskningsbeskrivning
- Fettväven är kroppens mest plastiska organ och största hormonproducent. Från att länge ha betraktats främst som en energilagrande vävnad, vet man nu att den spelar en central roll i utvecklingen av insulinresistens, dyslipidemi och atheroskleros vid kliniska tillstånd som övervikt/fetma, typ 2-diabetes, familjär kombinerad hyperlipidemi, kronisk njursvikt, cancer, kakexi och polycystiskt ovarialsyndrom. Forskningen omfattar cell- och molekylärbiologiska tekniker i olika cellkultursystem samt kliniska studier.
Artiklar
- Journal article: CARDIOVASCULAR RESEARCH (CVR). 2024;120(14):e54-e56
- Article: NATURE. 2024;:1-9
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2024;:108004
- Article: SLEEP. 2024;47(11):zsae160
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(21):11566
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(768):eado3022
- Article: OBESITY. 2024;32(8):1526-1540
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2024;48(7):934-940
- Article: NATURE METABOLISM. 2024;6(7):1329-1346
- Journal article: CLINICAL OBESITY. 2024;14(3):e12659
- Article: NATURE METABOLISM. 2024;6(5):861-879
- Article: JCI INSIGHT. 2024;9(8):e175623
- Article: NATURE METABOLISM. 2024;6(2):273-289
- Article: CLINICAL NUTRITION. 2024;43(2):468-475
- Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2024;17(1):e004192
- Article: CELL REPORTS MEDICINE. 2024;5(1):101348
- Article: SCIENCE ADVANCES. 2024;10(1):eadi2689
- Article: ADIPOCYTE. 2023;:2283213
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2023;325(5):C1178-C1189
- Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2023;43(6):1054-1065
- Article: LAKARTIDNINGEN. 2023;120:22140
- Article: NATURE COMMUNICATIONS. 2023;14(1):1438
- Article: DIABETES. 2023;72(3):316-325
- Article: FRONTIERS IN ENDOCRINOLOGY. 2023;14:1166961
- Article: SCIENTIFIC REPORTS. 2022;12(1):20519
- Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(4):667-678
- Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(2):296-307
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2022;46(6):1196-1203
- Article: JOURNAL OF INTERNAL MEDICINE. 2022;291(5):611-621
- Article: DIABETES. 2022;71(4):624-636
- Article: DEVELOPMENTAL CELL. 2022;57(3):387-397.e4
- Article: NATURE METABOLISM. 2022;4(2):190-202
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2022;132(2):e153357
- Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:996954
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2021;45(12):2675-2678
- Article: GASTROENTEROLOGY. 2021;161(6):1982-1997.e11
- Article: NATURE. 2021;599(7884):296-301
- Article: SCIENCE ADVANCES. 2021;7(43):eabi9654
- Article: CIRCULATION. 2021;144(12):961-982
- Article: ELIFE. 2021;10:e65996
- Article: CELL METABOLISM. 2021;33(9):1869-1882.e6
- Article: DISEASE MODELS & MECHANISMS. 2021;14(9):dmm048249
- Article: ADVANCED SCIENCE. 2021;8(16):e2100106
- Article: DIABETES. 2021;70(7):1486-1497
- Article: CELL. 2021;184(13):3502-3518.e33
- Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2021;118:154726
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2021;320(5):C822-C841
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2021;106(5):1312-1324
- Article: DIABETES. 2021;70(3):680-695
- Article: PLOS ONE. 2021;16(6):e0249666
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2020;44(12):2436-2443
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2020;105(12):dgaa492-e4416
- Article: JOURNAL OF INTERNAL MEDICINE. 2020;288(2):219-233
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2020;105(4):dgz245-e962
- Article: OBESITY SURGERY. 2020;30(3):1086-1092
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2020;12(532):eaaw9709
- Article: CELL METABOLISM. 2020;31(2):375-390.e11
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2020;44(2):377-387
- Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2019;101:153999
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2019;104(10):4552-4562
- Article: NATURE MEDICINE. 2019;25(9):1385-1389
- Article: EBIOMEDICINE. 2019;44:489-501
- Article: JOURNAL OF INTERNAL MEDICINE. 2019;285(5):578-588
- Article: NATURE METABOLISM. 2019;1(4):445-459
- Article: TRANSPLANTATION. 2019;103(3):630-637
- Article: NATURE METABOLISM. 2019;1(1):133-146
- Article: JOURNAL OF INTERNAL MEDICINE. 2019;285(1):92-101
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2018;42(12):2047-2056
- Article: CELL REPORTS. 2018;25(3):551-560.e5
- Article: DIABETES, OBESITY AND METABOLISM. 2018;20(10):2416-2425
- Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2018;472:50-56
- Article: CELL METABOLISM. 2018;28(1):45-54.e3
- Article: SURGERY FOR OBESITY AND RELATED DISEASES. 2018;14(7):936-942
- Article: DIABETOLOGIA. 2018;61(5):1112-1123
- Article: EBIOMEDICINE. 2018;30:248-260
- Article: AMERICAN JOURNAL OF HYPERTENSION. 2018;31(4):450-457
- Article: DIABETES AND METABOLISM. 2018;44(2):155-159
- Article: LAKARTIDNINGEN. 2018;115:EYWU
- Article: BIO-PROTOCOL. 2018;8(3):e2711
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2018;103(2):710-721
- Article: SCIENTIFIC REPORTS. 2018;8(1):1097
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2017;41(12):1815-1823
- Article: STEM CELL RESEARCH AND THERAPY. 2017;8(1):250
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2017;41(10):1564-1569
- Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2017;37(9):1782-1787
- Article: JOURNAL OF INTERNAL MEDICINE. 2017;282(3):220-228
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2017;41(8):1295-1298
- Article: STEM CELLS. 2017;35(7):1799-1814
- Article: NATURE COMMUNICATIONS. 2017;8:15253
- Article: OBESITY SURGERY. 2017;27(4):1115-1118
- Article: LAKARTIDNINGEN. 2017;114:ECLS
- Article: DIABETES CARE. 2017;40(1):77-84
- Article: DIABETES. 2017;66(1):218-230
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2016;101(11):4021-4029
- Article: DIABETOLOGIA. 2016;59(11):2393-2405
- Article: NATURE MEDICINE. 2016;22(10):1120-1130
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2016;101(10):3765-3771
- Article: CELL REPORTS. 2016;16(9):2317-2326
- Article: SCIENTIFIC REPORTS. 2016;6:28080
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2016;40(4):714-720
- Article: DIABETOLOGIA. 2016;59(3):560-570
- Article: DIABETES. 2016;65(2):433-437
- Article: NUTRITION AND METABOLISM. 2016;13:4
- Article: DIABETES AND METABOLISM. 2015;41(6):509-512
- Article: CELL METABOLISM. 2015;22(3):408-417
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2015;100(8):E1084-E1088
- Article: OBESITY. 2015;23(7):1371-1378
- Article: LAKARTIDNINGEN. 2015;112:DF6D
- Article: NATURE COMMUNICATIONS. 2015;6:7433
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2015;39(6):893-898
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2015;39(6):910-919
- Article: LIPIDS IN HEALTH AND DISEASE. 2015;14:42
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2015;39(2):222-227
- Article: OBESITY FACTS. 2015;8(2):147-155
- Article: CLINICAL EPIGENETICS. 2015;7(1):93
- Article: PLOS ONE. 2015;10(4):e0123566
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2014;99(10):E1870-E1876
- Article: DIABETES CARE. 2014;37(7):1831-1836
- Article: CELL METABOLISM. 2014;19(6):981-992
- Article: DIABETES. 2014;63(4):1248-1258
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2014;306(3):E267-E274
- Article: PLOS ONE. 2014;9(1):e86800
- Article: PLOS ONE. 2014;9(3):e80274
- Article: JOURNAL OF LIPID RESEARCH. 2013;54(10):2909-2913
- Article: DIABETOLOGIA. 2013;56(8):1792-1801
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2013;98(5):E897-E901
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2013;98(3):E503-E508
- Article: PLOS ONE. 2013;8(5):e63493
- Article: NUTRITION. 2012;28(9):851-855
- Article: DIABETES. 2012;61(8):1986-1993
- Article: JOURNAL OF INTERNAL MEDICINE. 2012;271(4):414-420
- Article: EUROPEAN JOURNAL OF NUTRITION. 2012;51(3):335-342
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2011;96(12):E2045-E2049
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2011;96(10):E1661-E1665
- Article: NATURE. 2011;478(7367):110-113
- Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2011;26(8):2485-2491
- Article: DIABETES. 2011;60(7):1917-1925
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2011;96(6):E962-E966
- Article: FEBS LETTERS. 2011;585(5):744-748
- Article: BRITISH JOURNAL OF CANCER. 2011;104(3):441-447
- Article: LAKARTIDNINGEN. 2011;108(4):136
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(1):370-379
- Article: OBESITY FACTS. 2011;4(5):365-371
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2011;96(1):133-141
- Article: DIABETOLOGIA. 2010;53(12):2496-2503
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2010;34(8):1333-1340
- Article: BRITISH JOURNAL OF CANCER. 2010;102(10):1541-1548
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2010;95(5):2451-2457
- Article: DIABETES. 2010;59(3):564-571
- Article: BMC ENDOCRINE DISORDERS. 2010;10:1
- Article: DIABETES. 2010;59(1):105-109
- Article: ENDOCRINOLOGY. 2009;150(9):4104-4113
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2009;94(8):3003-3009
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(27):18282-18291
- Article: HORMONE AND METABOLIC RESEARCH. 2009;41(5):350-355
- Article: CIRCULATION RESEARCH. 2009;104(8):961-968
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2009;33(1):67-74
- Article: CANCER RESEARCH. 2008;68(22):9247-9254
- Article: LAKARTIDNINGEN. 2008;105(42):2910-2911
- Article: CANCER. 2008;113(7):1695-1704
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2008;32(9):1380-1387
- Article: NATURE. 2008;453(7196):783-787
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2008;93(6):2249-2254
- Article: FEBS LETTERS. 2008;582(12):1725-1730
- Article: PLOS ONE. 2008;3(3):e1713
- Article: AMERICAN JOURNAL OF TRANSPLANTATION. 2008;8(2):458-462
- Article: DIABETOLOGIA. 2008;51(2):227-232
- Article: DIABETES. 2008;57(2):378-386
- Article: PLOS ONE. 2008;3(11):e3771
- Article: JOURNAL OF INTERNAL MEDICINE. 2007;262(4):431-438
- Article: FERTILITY AND STERILITY. 2007;88(1):100-106
- Article: CANCER RESEARCH. 2007;67(11):5531-5537
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2007;31(6):900-907
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2007;292(6):E1847-E1855
- Article: JOURNAL OF LIPID RESEARCH. 2007;48(5):1069-1077
- Article: OBESITY. 2007;15(4):846-852
- Article: JOURNAL OF LIPID RESEARCH. 2007;48(1):201-206
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2006;30(3):447-452
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2005;29(12):1413-1421
- Article: DIABETES. 2005;54(11):3190-3197
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2005;90(9):5356-5360
- Article: EXPERIMENTAL CELL RESEARCH. 2005;308(2):283-290
- Article: DIABETES. 2005;54(6):1726-1734
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;318(1):168-175
- Article: JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2004;15(5):303-312
- Article: JOURNAL OF INTERNAL MEDICINE. 2004;255(5):595-601
- Article: DIABETOLOGIA. 2004;47(3):420-428
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2004;28(2):185-190
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;311(2):391-397
- Article: DIABETOLOGIA. 2003;46(6):789-797
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2003;88(5):2269-2273
- Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2002;32(12):938-942
- Article: DIABETES. 2002;51(12):3376-3383
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2002;26(10):1379-1385
- Article: DIABETES. 2002;51(7):2029-2036
- Article: DIABETES. 2002;51(5):1601-1608
- Article: DIABETOLOGIA. 2002;45(2):276-282
- Article: DIABETES. 2002;51(2):484-492
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2002;87(2):764-771
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(2):1085-1091
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2001;25(11):1599-1603
- Article: DIABETOLOGIA. 2001;44(10):1268-1273
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2001;25(6):811-815
- Article: JOURNAL OF LIPID RESEARCH. 2000;41(8):1244-1251
- Article: DIABETES. 2000;49(5):688-692
- Article: DIABETOLOGIA. 2000;43(1):117-120
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(52):33085-33091
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(26):16322-16328
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(48):30603-30609
- Article: BRITISH JOURNAL OF CANCER. 1996;74(5):773-779
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(10):5623-5627
- Article: JOURNAL OF CELL BIOLOGY. 1995;130(1):137-148
- Article: EMBO JOURNAL. 1995;14(9):1979-1990
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Alla övriga publikationer
- Review: CLINICAL ENDOCRINOLOGY. 2024;101(1):3-9
- Preprint: RES SQ. 2023;RES SQ
- Editorial comment: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(5):269-270
- Review: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2022;274:131-144
- Review: INTERNATIONAL JOURNAL OF OBESITY. 2021;45(5):934-943
- Review: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2021;41(4):1284-1290
- Corrigendum: NATURE METABOLISM. 2021;3(2):287
- Review: CURRENT OPINION IN PHARMACOLOGY. 2020;55:47-52
- Letter: CELL METABOLISM. 2020;32(1):1-3
- Review: ADIPOCYTE. 2020;9(1):620-625
- Corrigendum: NATURE METABOLISM. 2019;1(4):497
- Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2018;29(10):675-685
- Editorial comment: CARDIOVASCULAR RESEARCH (CVR). 2018;114(3):e19-e21
- Review: ADIPOCYTE. 2017;6(3):187-192
- Corrigendum: DIABETOLOGIA. 2016;59(12):2728
- Editorial comment: ADIPOCYTE. 2016;5(3):312-317
- Review: INTERNATIONAL JOURNAL OF OBESITY. 2012;36(12):1494-1502
- Review: LAKARTIDNINGEN. 2010;107(45):2810-2814
- Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2010;362(12):1151-1153
- Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2009;66(13):2067-2073
- Review: CLINICAL NUTRITION. 2007;26(1):1-6
- Letter: DIABETOLOGIA. 2001;44(5):654-655
- Published conference paper: EUROPEAN JOURNAL OF CANCER. 1997;33(12):2058-2063
- Thesis / dissertation: 1997
- Review: LAKARTIDNINGEN. 1995;92(21):2191-2194
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Anställningar
- Professor/Överläkare, Medicin, Huddinge, Karolinska Institutet, 2013-
Examina och utbildning
- Docent, Experimentell endokrinologi, Karolinska Institutet, 2002
- Läkarexamen, Karolinska Institutet, 1996