Melody Chemaly

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Journal article: JOURNAL OF VASCULAR SURGERY. 2025;81(5):a15-a16
Atherosclerotic plaque instability in symptomatic non-significant carotid stenoses
Cyréus P; Wadén K; Hellberg S; Bergman O; Lengquist M; Karlöf E; Buckler A; Matic L; Roy J; Marlevi D; Chemaly M; Hedin U
Journal article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2025
NLRP3 Inflammasome Inhibition by the Novel Bispecific Antibody InflamAb Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice
Delfos L; Depuydt MAC; Chemaly M; Coyle S; Schaftenaar FH; van Santbrink PJ; Lindenbergh PP; Kleijn MNAB; Costello C; Power CA; Coll R; Peace A; Gregory-Ksander M; Foks AC; Kuiper J; McGilligan V; Bot I
Article: JVS - VASCULAR SCIENCE. 2025;6:100280
Atherosclerotic plaque instability in symptomatic non-significant carotid stenoses
Cyreus P; Waden K; Hellberg S; Bergman O; Lengquist M; Buckler A; Karlof E; Matic L; Roy J; Marlevi D; Chemaly M; Hedin U
Journal article: CELLS. 2024;13(19):1613
Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients
McVallion S; McLarnon T; Cooper E; English AR; Watterson S; Chemaly ME; McGeough C; Eakin A; Ahmed T; Gardiner P; Pendleton A; Wright G; McGuigan D; O'Kane M; Peace A; Kuan Y; Gibson DS; McClean PL; Kelly C; McGilligan V; Murray EK; McCarroll F; Bjourson AJ; Rai TS
Journal article: ATHEROSCLEROSIS. 2024;395:117757
MULTI-OMICS INTEGRATION FROM A LARGE HUMAN BIOBANK IDENTIFIES KEY MOLECULAR MECHANISMS AND SIGNATURES OF ATHEROSCLEROTIC PLAQUE INSTABILITY
Das V; Zhang X; Djordjevic D; Bergman O; Narayanan S; Shungin D; Chemaly M; Karadimou G; Vuckovic S; Prasad I; Knape KC; Michaelsen NB; Hedin U; Matic L
Journal article: CARDIOVASCULAR RESEARCH. 2024;120:cvae088.208
The novel bispecific anti-NLRP3 inflammasome antibody InflamAb inhibits atherosclerosis in apolipoprotein E-deficient mice
Delfos L; Depuydt MAC; Kleijn MNAB; Foks AC; Kuiper J; Chemaly M; Peace A; Mcgilligan V; Bot I
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024;44:a143
Multi-omics Integration From A Large Human Biobank Identifies Key Molecular Mechanisms And Signatures Of Atherosclerotic Plaque Instability
Das V; Zhang X; Djordjevic D; Bergman O; Narayanan S; Shungin D; Chemaly M; Karadimou G; Vuckovic S; Prasad I; Knape KC; Michaelsen NB; Hedin U; Matic L
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024;44:a131
Local Pcsk6 Inhibition Attenuates VSMC Response In Vascular Injury And Restenosis
Chemaly M; Jin H; Vuckovic S; Suur BE; Zhang X; Kronqvist M; Lengquist M; Uryga A; Knape KC; Nyberg M; Hedin U; Matic L; Matic L
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024;44:a1155
Symptomatic Low- And High-degree Carotid Stenoses Exhibit Similar Features Of Plaque Instability
Shlemoun P; Hellberg S; Waden K; Bergman O; Lengquist M; Buckler AJ; Matic L; Chemaly M; Marlevi D; Hedin U
Journal article: JVS - VASCULAR SCIENCE. 2024;5:100260
Symptomatic Low- And High-degree Carotid Stenoses Exhibit Similar Features of Plaque Instability
Shlemoun P; Hellberg S; Waden K; Bergman O; Lengquist M; Buckler AJ; Matic L; Chemaly M; Marlevi D; Hedin U
Journal article: EJVES SHORT REPORTS. 2024;62:s11-S10
Local PCSK6 Inhibition Attenuates VSMC Response in Vascular Injury and Restenosis
Chemaly M; Jin H; Vuckovic S; Suur BE; Zhang X; Kronqvist M; Lengquist M; Uryga A; Knape KC; Nyberg M; Hedin U; Matic L
Journal article: ATHEROSCLEROSIS. 2023;379:s180
BILIVERDIN REDUCTASE B IS A PLASMA BIOMARKER FOR INTRAPLAQUE HEMORRHAGE AND A PREDICTOR OF ISCHEMIC STROKE IN SYMPTOMATIC CAROTID STENOSIS
Chemaly M; Marlevi D; Iglesias M-J; Lengquist M; Kronqvist M; Bos D; Van Dam-Nolen DHK; Van Der Kolk A; Hendrikse J; Kassem M; Matic L; Odeberg J; De Vries MR; Kooi ME; Hedin U
Journal article: ATHEROSCLEROSIS. 2023;379:s2
NLRP3 INFLAMMASOME INHIBITION BY THE NOVEL BISPECIFIC ANTIBODY INFLAMAB INHIBITS ATHEROSCLEROSIS IN APOLIPOPROTEIN E-DEFICIENT MICE
Delfos L; Depuydt MAC; Foks A; Kleijn MB; Kuiper J; Chemaly M; Peace A; Mcgilligan V; Bot I
Article: BIOMOLECULES. 2023;13(6):882
Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis
Chemaly M; Marlevi D; Iglesias M-J; Lengquist M; Kronqvist M; Bos D; van Dam-Nolen DHK; van der Kolk A; Hendrikse J; Kassem M; Matic L; Odeberg J; de Vries MR; Kooi ME; Hedin U
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023;43
Biliverdin Reductase B Is A Plasma Biomarker For Intraplaque Hemorrhage And A Predictor Of Ischemic Stroke In Symptomatic Carotid Stenosis
Chemaly M; Marlevi D; Mareque MJI; Lengquist M; Kronqvist M; Bos D; van Dam-Nolen DHK; van der Kolk A; Hendrikse J; Kassem M; Matic L; Odeberg J; De Vries MR; Kooi ME; Hedin U
Journal article: JVS - VASCULAR SCIENCE. 2023;4:100142
Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Symptomatic Carotid Stenosis
Chemaly M; Marlevi D; Mareque MJI; Lengquist M; Kronqvist M; Bos D; van Dam-Nolen DHK; van der Kolk A; Hendrikse J; Kassem M; Matic L; Odeberg J; De Vries MR; Kooi ME; Hedin U
Article: ATHEROSCLEROSIS PLUS. 2022;50:40-49
TACE/ADAM17 substrates associate with ACS (Ep-CAM, HB-EGF) and follow-up MACE (TNFR1 and TNFR2)
Chemaly M; McAllister R; Peace A; Bjourson AJ; Watterson S; Parton A; Clauss M; McGilligan V
Journal article: ATHEROSCLEROSIS. 2022;355:24
Novel roles of PCSK6 in adipose tissue homeostasis
Chemaly M; Suur B; Schipper R; Jin H; Hagberg C; Matic LP
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2022;42:a420
Proprotein Convertase Subtilisin/Kexin 6 Is Involved In Lipid Metabolism In Liver
Suur B; Chemaly M; Karadimou G; Jin H; Kronqvist M; Lengquist M; van der Laan SW; Lleal MS; Malarstig A
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2022;42:a419
Therapeutic Potential Of The Proprotein Convertase Subtilisin/Kexin ( PCSK) Family In Vascular Disease
Suur BE; Chemaly M; Liljeqvist ML; Djordjevic D; Stenemo M; Bergman O; Karlof E; Lengquist M; Odeberg J
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2022;42:a105
Proprotein Convertase Subtilisin/kexin Type 6 (Pcsk6) Plays A Role In Angiogenesis Regulation
Chemaly M; Dong X; Suur BE; Jin H; Malarstig A; Matic L
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:988561
Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease
Suur BE; Chemaly M; Liljeqvist ML; Djordjevic D; Stenemo M; Bergman O; Karlof E; Lengquist M; Odeberg J; Hurt-Camejo E; Eriksson P; Ketelhuth DFJ; Roy J; Hedin U; Nyberg M; Matic L
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41
Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6) Is Involved In Regulation Of Vasculogenesis
Chemaly M; Suur BE; Jin H; Malarstig A; Matic L
Journal article: ONLINE JOURNAL OF CARDIOVASCULAR RESEARCH. 2019;3(2)
The NLRP3 Inflammasome as a promising target for Coronary Artery Disease: Current and Pipeline NLRP3 Inhibitors
McGilligan V
Journal article: JOURNAL OF ELECTROCARDIOLOGY. 2019;57:S92-S97
An exploratory analysis investigating blood protein biomarkers to augment ECG diagnosis of ACS
McGilligan V; Watterson S; Rjoob K; Chemaly M; Bond R; Iftikhar A; Knoery C; Leslie SJ; McShane A; Bjourson A; Peace A
Journal article: BIOINFORMATICS. 2019;35(14):2449-2457
New models of atherosclerosis and multi-drug therapeutic interventions
Parton A; McGilligan V; Chemaly M; O'Kane M; Watterson S
Journal article: MEDIATORS OF INFLAMMATION. 2019;2019:2363460-11
Exploring the Involvement of NLRP3 and IL-1β in Osteoarthritis of the Hand: Results from a Pilot Study
Fioravanti A; Tenti S; McAllister M; Chemaly M; Eakin A; McLaughlin J; Bjourson AJ; Frati E; McGilligan V; Cheleschi S; Gibson DS
Journal article: OSTEOARTHRITIS AND CARTILAGE. 2018;26(5):612-619
NLRP3 as a potentially novel biomarker for the management of osteoarthritis
McAllister MJ; Chemaly M; Eakin AJ; Gibson DS; McGilligan VE
Journal article: ARCHIVES OF CARDIOVASCULAR DISEASES. 2017;110(12):700-711
Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events
Chemaly M; McGilligan V; Gibson M; Clauss M; Watterson S; Alexander HD; Bjourson AJ; Peace A
Journal article: EUROPEAN HEART JOURNAL. 2017;38(suppl_1):ehx493.p6229
P6229TACE gene expression and soluble receptors TNFRI and TNFRII levels identifies very high risk cardiovascular patients
Chemaly M; Gibson M; Watterson S; Bjourson T; McGilligan V; Peace A
Journal article: CURRENT ATHEROSCLEROSIS REPORTS. 2014;16(9):439
Living the PCSK9 Adventure: from the Identification of a New Gene in Familial Hypercholesterolemia Towards a Potential New Class of Anticholesterol Drugs
Abifadel M; Elbitar S; El Khoury P; Ghaleb Y; Chemaly M; Moussalli M-L; Rabes J-P; Varret M; Boileau C
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Conference publication: 2025;:a8.3-a8a9
P12 NLRP3 inflammasome-associated proteins as predictors of recurrent cardiac events
Costello C; Chemaly M; McDaid-McCloskey S-L; Coyle S; Peace A; AJ B; Watterson S; McGilligan V
Dataset: 2025
ATVB_net: Article Commentary: Insights into the protective role of resident memory T cells in atherosclerosis: Small memories with big impact
Preprint: PREPRINTS.ORG. 2024
Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients
McCallion S; McLarnon T; Cooper E; English AR; Watterson S; Chemaly ME; McGeough CM; Eakin A; Ahmed T; Gardiner P; Pendleton A; Wright G; McGuigan D; O’Kane M; Peace A; Kuan Y; Gibson DS; McClean PL; Kelly C; McGilligan VE; Murray EK; McCarroll F; Bjourson AJ; Singh T
Preprint: BIORXIV. 2024;BIORXIV
Multiomics unveils extracellular vesicle-driven mechanisms of endothelial communication in human carotid atherosclerosis.
Raju S; Turner ME; Cao C; Abdul-Samad M; Punwasi N; Blaser MC; Cahalane RM; Botts SR; Prajapati K; Patel S; Wu R; Gustafson D; Galant NJ; Fiddes L; Chemaly M; Hedin U; Matic L; Seidman M; Subasri V; Singh SA; Aikawa E; Fish JE; Howe KL
Editorial comment: CARDIOVASCULAR RESEARCH. 2024;120(8):811-813
NOT lost in translation: translatome mapping as a novel approach to identify regulators of atherosclerosis
Matic L; Chemaly M; Jorgensen HF
Dataset: 2024
ATVB_net: Article Commentary: Atherosclerotic plaque vulnerability differs between sexes: Novel insights on the role of SMCs in disease modulation
Editorial comment: ATHEROSCLEROSIS. 2023;387:117365
The more the merrier: Severe vascular injury increases engagement of smooth muscle cell clones in intimal repair
Hedin U; Chemaly M; Matic L
Dataset: 2023
ATVB_net: Article Commentary: Clonality- The link between aging and cardiovascular diseases
Editorial comment: CARDIOVASCULAR RESEARCH. 2023;119(5):1100-1102
Smooth muscle cell oligoclonality in vascular disease: same origin, different destinies
Matic L; Chemaly M; Hedin U
Conference publication: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180:790-791
NLRP3 Inflammasome associated proteins are predictive of COVID19 patient hospitalisation
Donnelly S; Bond R; Peace A; Rai TS; Lynch S; McDaid D; McLaughlin J; English A; Walsh C; Shulka P; Murray E; Zhang S-D; Chemaly M; O'Kane M; Kelly M; Bhavsar M; Gibson D; Bjourson T; McGilligan V
Conference publication: DIABETOLOGIA. 2023;66(SUPPL 1):S129-S130
Application of multiomics to identify novel molecular mechanisms of atherosclerotic plaque instability in type 2 diabetes patients
Das V; Zhang X; Djordjevic D; Bergman O; Chemaly M; Shungin D; Michaelsen N; Knape K; Hedin U; Matic L
Conference publication: ATHEROSCLEROSIS. 2022;355:E54-E55
NOVEL ROLES OF PCSK6 IN ADIPOSE TISSUE HOMEOSTASIS
Chemaly M; Suur B; Schipper R; Jin H; Hagberg C; Matic LP
Review: BIOMOLECULES. 2021;11(8):1239
Targeting the NLRP3 Inflammasome in Glaucoma
Coyle S; Khan MN; Chemaly M; Callaghan B; Doyle C; Willoughby CE; Atkinson SD; Gregory-Ksander M; McGilligan V
Conference publication: ATHEROSCLEROSIS. 2021;331:E4
PROPROTEIN CONVERTASE SUBTILISIN/KEXIN 6 IS INVOLVED IN LIPID METABOLISM IN LIVER AND ADIPOSE TISSUE
Suur BE; Chemaly M; Jin H; Kronqvist M; Lengquist M; Van der Laan SW; Lleal MS; Malarstig A; Pasterkamp G; Eriksson P; Hedin U; Ketelhuth DFJ; Hurt-Camejo E; Matic L
Conference publication: HEART. 2020;106(Suppl 1):a8
P8 A freely available, simple-to-use, computational model of atherosclerosis
Watterson S; Parton A; McGilligan V; Chemaly M; O’Kane M
Conference publication: COMPUTING IN CARDIOLOGY. 2020;:1-4
Improving the Detection of Acute Coronary Syndrome Using Machine Learning of Blood Biomarkers
Rjoob K; McGilligan V; Bond R; Watterson S; Chemaly M; McAlister R; Malaquias TDM; Leslie SJ; Knoery C; Iftikhar A; McShane A; Bjourson A; Peace A
Conference publication: HEART. 2017;103(Suppl 6):a31-A32
54 The nlrp3 inflammasome and other related receptors as potential biomarkers in coronary artery disease (cad) and major adverse cardiac events (mace)
Gallagher L; McCusker M; Chemaly M; Peace A; Gibson M; Bjourson A; Kelly C; McGilligan V

Anställningar

Forskningsspecialist, Molekylär medicin och kirurgi, Karolinska Institutet, 2025-
Postdoktor, Molekylär medicin och kirurgi, Karolinska Institutet, 2020-2025

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