Marco Gerling

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Populärvetenskap och samverkan

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Artiklar

Article: CURRENT OPINION IN CELL BIOLOGY. 2024;86:102315

Cellular spartans at the pass: Emerging intricacies of cell competition in early and late tumorigenesis

Moro CF; Geyer N; Gerling M
Journal article: HPB. 2024;26:s167-s168

Recurrence pattern and treatment following repeat hepatectomy for colorectal cancer liver metastases

Kern AE; Eriksson S; Bringfors K; Gerling M; Engstrand J
Journal article: HPB. 2024;26:s173-s174

Impact of post-hepatectomy liver failure on recurrence following major hepatectomy for colorectal cancer liver metastases

Sterner J; Andersson M; Moro CF; Jansson H; Strömberg C; Sparrelid E; Gilg S; Gerling M; Engstrand J
Article: NPJ BREAST CANCER. 2023;9(1):100

Histopathological growth patterns and tumor-infiltrating lymphocytes in breast cancer liver metastases

Leduc S; De Schepper M; Richard F; Maetens M; Pabba A; Borremans K; Jaekers J; Latacz E; Zels G; Bohlok A; Van Baelen K; Nguyen HL; Geukens T; Dirix L; Larsimont D; Vankerckhove S; Santos E; Oliveira RC; Dede K; Kulka J; Borbala S; Salamon F; Madaras L; Marcell Szasz A; Lucidi V; Meyer Y; Topal B; Verhoef C; Engstrand J; Moro CF; Gerling M; Bachir I; Biganzoli E; Donckier V; Floris G; Vermeulen P; Desmedt C
Journal article: BJC REPORTS. 2023;1(1):19

What’s in a name? Refining the nomenclature of liver metastases growth patterns by changing “desmoplastic” to “encapsulated”

Fernández Moro C; Bozóky B; Geyer N; Engstrand J; Dirix L; Vermeulen P; Gerling M
Journal article: ANNALS OF ONCOLOGY. 2023;34:s276-s277

GUIDE.MRD: A Consortium guiding multi-modal therapies against minimal residual disease (MRD) by liquid biopsy to assess implementation of circulating tumor DNA (ctDNA) in clinical practice to improve patient outcomes

Pantel K; Andersen CL; Schuuring E; Malats N; Heitzer E; Vat L; Kiernan E; Chin E; Barrett C; Kapp R; Thomas M; Gerling M; Reck M; Lohr M; Hofman P; Hiltermann N; Alix-Panabieres C; Smit J; Bolisetty M; Karasarides M
Article: NATURE COMMUNICATIONS. 2023;14(1):5024

An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver

Moro CF; Geyer N; Harrizi S; Hamidi Y; Soderqvist S; Kuznyecov D; Tidholm Qvist E; Salmonson Schaad M; Hermann L; Lindberg A; Heuchel RL; Martin-Bernabe A; Dhanjal S; Navis AC; Villard C; del Valle AC; Bozoky L; Sparrelid E; Dirix L; Strell C; Ostman A; Schmierer B; Vermeulen PB; Engstrand J; Bozoky B; Gerling M
Journal article: CANCER RESEARCH. 2023;83(5):p6-14-06-p6-14-06

Histopathological and immune characterization of liver metastases from patients with breast cancer

Leduc S; De Schepper M; Vermeulen P; Floris G; Biganzoli E; Donckier V; Bohlok A; Gerling M; Richard F; Maetens M; Jaekers J; Topal B; Latacz E; Van Baelen K; Geukens T; Nguyen HL; Dirix L; Larsimont D; Van Kerckhove S; Oliveira RC; Kulka J; Lucidi V; Meyer Y; Verhoef C; Santos E; Salamon F; Madaras L; Szasz AM; Borbala S; Dede K; Engstrand J; Moro CF; Desmedt C
Article: EJSO. 2022;48(7):1656-1663

Prognostic impact of inter-metastatic heterogeneity of viable tumour cells in colorectal liver metastases

Stromberg C; de la Maza LM; Moro CF; Gerling M; Jorns C; Sparrelid E; Lohr MJ; Villard C
Article: FRONTIERS IN ONCOLOGY. 2022;12:965182

Drug-induced tumor-specific cytotoxicity in a whole tissue ex vivo model of human pancreatic ductal adenocarcinoma

Moro CF; Selvam AK; Ghaderi M; Pimenoff VN; Gerling M; Bozoky B; Elduayen SP; Dillner J; Bjoernstedt M
Article: NEOPLASIA. 2021;23(12):1300-1306

Stabilization of the classical phenotype upon integration of pancreatic cancer cells into the duodenal epithelium

Bozoky B; Moro CF; Strell C; Geyer N; Heuchel RL; Lohr JM; Ernberg I; Szekely L; Gerling M; Bozoky B
Article: TRANSGENIC RESEARCH. 2021;30(5):701-707

Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Kruppel-like factor 5 (Klf5)

Bergstrom A; Gerling M; Van Hul N; Fernandez Moro C; Rozell B; Toftgard R; Sur I
Article: NATURE METHODS. 2021;18(8):912-920

An unsupervised method for physical cell interaction profiling of complex tissues

Andrews N; Serviss JT; Geyer N; Andersson AB; Dzwonkowska E; Sutevski I; Heijboer R; Baryawno N; Gerling M; Enge M
Article: ELIFE. 2020;9:e46756

Coordinated hedgehog signaling induces new hair follicles in adult skin

Sun X; Are A; Annusver K; Sivan U; Jacob T; Dalessandri T; Joost S; Fullgrabe A; Gerling M; Kasper M
Article: ONCOGENE. 2019;38(28):5670-5685

Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis

Rohwer N; Jumpertz S; Erdem M; Egners A; Warzecha KT; Fragoulis A; Kuehl AA; Kramann R; Neuss S; Rudolph I; Endermann T; Zasada C; Apostolova I; Gerling M; Kempa S; Hughes R; Lewis CE; Brenner W; Malinowski MB; Stockmann M; Schomburg L; Faller W; Sansom OJ; Tacke F; Morkel M; Cramer T
Journal article: GASTROENTEROLOGY. 2019;156(6):s-445

Sa1897 – HDAC Inhibitors Drive TGF-β1-Mediated Strengthening and Regeneration of the Intestinal Epithelial Barrier During Inflammation

Gerbeth L; Friedrich M; Gerling M; Rosenthal R; Weidinger C; Keye J; Wu H; Schmidt F; Siegmund B; Glauben R
Article: MUCOSAL IMMUNOLOGY. 2019;12(3):656-667

HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGFβ1 signalling in inflammation

Friedrich M; Gerbeth L; Gerling M; Rosenthal R; Steiger K; Weidinger C; Keye J; Wu H; Schmidt F; Weicheret W; Siegmund B; Glauben R
Article: ESMO OPEN. 2019;4(6):e000607

Variations in the management of diarrhoea induced by cancer therapy: results from an international, cross-sectional survey among European oncologists

Kordes M; Gerling M
Article: BMJ OPEN GASTROENTEROLOGY. 2018;5(1):e000217

Growth patterns of colorectal cancer liver metastases and their impact on prognosis: a systematic review

Moro CF; Bozoky B; Gerling M
Article: DEVELOPMENTAL BIOLOGY. 2017;429(1):132-146

Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model

Hoelzl MA; Heby-Henricson K; Gerling M; Dias JM; Kuiper RV; Trunkle C; Bergstrom A; Ericson J; Toftgard R; Teglund S
Journal article: PROTOCOL EXCHANGE. 2017

3D high-frequency ultrasound of the mouse colon to monitor tumor development

Gerling M; Nania S; Blaas L; Gerling M
Article: NATURE CELL BIOLOGY. 2016;18(12):1346-1356

Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours

Blaas L; Pucci F; Messal HA; Andersson AB; Ruiz EJ; Gerling M; Douagi I; Spencer-Dene B; Musch A; Mitter R; Bhaw L; Stone R; Bornhorst D; Sesay AK; Jonkers J; Stamp G; Malanchi I; Toftgard R; Behrens A
Article: NATURE COMMUNICATIONS. 2016;7:12321

Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

Gerling M; Buller NVJA; Kirn LM; Joost S; Frings O; Englert B; Bergstrom A; Kuiper RV; Blaas L; Wielenga MCB; Almer S; Kuhl AA; Fredlund E; van den Brink GR; Toftgard R
Article: NATURE COMMUNICATIONS. 2016;7:11314

FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice

Bosma M; Gerling M; Pasto J; Georgiadi A; Graham E; Shilkova O; Iwata Y; Almer S; Soderman J; Toftgard R; Wermeling F; Bostrom EA; Bostrom PA
Journal article: ZEITSCHRIFT FUR GASTROENTEROLOGIE. 2015;53(08)

Aktivierung des Hedgehog Signalwegs im Kolonstroma hemmt Entstehung und Progression von kolorektalen Tumoren

Gerling M; Kirn L; Büller N; Englert B; Frings O; Fredlund E; Kühl A; Kuiper R; van den Brink G; Toftgård R
Article: CLINICAL SCIENCE. 2015;129(3):281-290

Interleukin 34: a new modulator of human and experimental inflammatory bowel disease

Zwicker S; Martinez GL; Bosma M; Gerling M; Clark R; Majster M; Soderman J; Almer S; Bostrom EA
Article: THERANOSTICS. 2014;4(6):604-613

Real-Time Assessment of Tissue Hypoxia In Vivo with Combined Photoacoustics and High-Frequency Ultrasound

Gerling M; Zhao Y; Nania S; Norberg KJ; Verbeke CS; Englert B; Kuiper RV; Bergstrom A; Hassan M; Neesse A; Lohr JM; Heuchel RL
Article: INFLAMMATORY BOWEL DISEASES. 2013;19(4):691-703

Aneuploidy-Associated Gene Expression Signatures Characterize Malignant Transformation in Ulcerative Colitis

Gerling M; Nousiainen K; Hautaniemi S; Krueger S; Fritzsche B; Homann N; Bruch H-P; Auer G; Roblick UJ; Ried T; Habermann JK
Article: PLOS ONE. 2011;6(7):e22114

Characterization of Chromosomal Instability in Murine Colitis-Associated Colorectal Cancer

Gerling M; Glauben R; Habermann JK; Kuehl AA; Loddenkemper C; Lehr H-A; Zeitz M; Siegmund B
Article: ANNALS OF SURGERY. 2010;252(1):74-83

High Frequency of Aneuploidy Defines Ulcerative Colitis-Associated Carcinomas A Prognostic Comparison to Sporadic Colorectal Carcinomas

Gerling M; Meyer KF; Fuchs K; Igl BW; Fritzsche B; Ziegler A; Bader F; Kujath P; Schimmelpenning H; Bruch H-P; Roblick UJ; Habermann JK
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Preprint: MEDRXIV. 2024

Cytokine release syndrome after treatment with immune checkpoint inhibitors: an observational cohort study of 2672 patients from Karolinska University Hospital in Sweden

Hamida O; Karlsson F; Lundqvist A; Gerling M; Liu LL
Preprint: BIORXIV. 2024

A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotype

Söderqvist S; Viljamaa A; Geyer N; Strell C; Hekmati N; Engstrand J; Sparrelid E; Salmén C; Heuchel RL; Zacharouli A; Ghorbani P; Harrizi S; Hamidi Y; Khorosjutina O; Milanova S; Schmierer B; Bozóky B; Moro CF; Gerling M
Review: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2023;11(3):e005841

Systemic inflammatory syndromes as life-threatening side effects of immune checkpoint inhibitors: case report and systematic review of the literature

Liu LL; Skribek M; Harmenberg U; Gerling M
Other: CASE REPORTS IN ONCOLOGY. 2023;16(1):525-531

Transient Coma and Signs of Encephalopathy Related to 5-Fluorouracil and Carboplatin: A Case Report

Zupancic M; Farrajota Neves da Silva P; Kas Elyas K; Friesland S; Ellingsen Cederoe T; Gerling M
Review: BRITISH JOURNAL OF CANCER. 2022;127(6):988-1013

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights

Latacz E; Hoppener D; Bohlok A; Leduc S; Tabaries S; Fernandez Moro C; Lugassy C; Nystrom H; Bozoky B; Floris G; Geyer N; Brodt P; Llado L; Van Mileghem L; De Schepper M; Majeed AW; Lazaris A; Dirix P; Zhang Q; Petrillo SK; Vankerckhove S; Joye I; Meyer Y; Gregorieff A; Roig NR; Vidal-Vanaclocha F; Denis L; Oliveira RC; Metrakos P; Grunhagen DJ; Nagtegaal ID; Mollevi DG; Jarnagin WR; D'Angelica MI; Reynolds AR; Doukas M; Desmedt C; Dirix L; Donckier V; Siegel PM; Barnhill R; Gerling M; Verhoef C; Vermeulen PB
Preprint: MEDRXIV. 2022

An idiosyncratic, zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver

Fernández Moro C; Harrizi S; Hamidi Y; Geyer N; Kuznyecov D; Tidholm-Qvist E; Salmonson Schaad M; del Valle A; Söderqvist S; Bozóky L; Sparrelid E; Dirix L; Vermeulen P; Bozóky B; Engstrand J; Gerling M
Preprint: MEDRXIV. 2022

Systemic inflammatory syndromes as life-threatening side effects of immune checkpoint inhibitors: Systematic review of the literature

Liu LL; Skribek M; Harmenberg U; Gerling M
Preprint: MEDRXIV. 2022

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives, and recent mechanistic insights

Latacz E; Höppener D; Bohlok A; Leduc S; Tabariès S; Moro CF; Lugassy C; Nyström H; Bozóky B; Floris G; Geyer N; Brodt P; Llado L; Mileghem LV; Schepper MD; Majeed A; Lazaris A; Dirix P; Zhang Q; Petrillo S; Vankerckhove S; Joye I; Meyer Y; Gregorieff A; Roig NR; Vidal-Vanaclocha F; Denis L; Oliveira RC; Metrakos P; Grünhagen D; Nagtegaal I; Mollevi D; Jarnagin W; D’Angelica M; Reynolds A; Doukas M; Desmedt C; Dirix L; Donckier V; Siegel P; Barnhill R; Gerling M; Verhoef C; Vermeulen P
Preprint: BIORXIV. 2021

Basal-to-classical phenotypic switch of pancreatic cancer cells upon integration into the duodenal epithelium

Bozóky B; Moro CF; Strell C; Ernberg I; Szekely L; Gerling M; Bozóky B
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1025

Hedgehog Signaling in Colorectal Cancer: All in the Stroma?

Geyer N; Gerling M
Preprint: BIORXIV. 2020

Unsupervised cell interaction profiling reveals major architectural differences between small intestinal and colonic epithelial crypts

Serviss J; Andrews N; Andersson A; Dzwonkowska E; Heijboer R; Geyer N; Gerling M; Enge M
Review: ANGIOGENESIS. 2020;23(1):43-54

Pathological features of vessel co-option versus sprouting angiogenesis

Latacz E; Caspani E; Barnhill R; Lugassy C; Verhoef C; Grunhagen D; Van Laere S; Moro CF; Gerling M; Dirix M; Dirix LY; Vermeulen PB
Conference publication: ACTA PHYSIOLOGICA. 2019;227

Using single cell genomics to study cancer as a tissue - cell types and organ structure in malignancies

Zachariadis V; Andrews N; Serviss J; Cheng H; Dzwonkowska E; Gerling M; Enge M
Conference publication: GASTROENTEROLOGY. 2019;156(6):S445

HDAC INHIBITORS DRIVE TGF-β1-MEDIATED STRENGTHENING AND REGENERATION OF THE INTESTINAL EPITHELIAL BARRIER DURING INFLAMMATION

Gerbeth L; Friedrich M; Gerling M; Rosenthal R; Weidinger C; Keye J; Wu H; Schmidt F; Siegmund B; Glauben R
Preprint: BIORXIV. 2018

Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis

Rohwer N; Jumpertz S; Erdem M; Egners A; Warzecha KT; Fragoulis A; Kühl AA; Kramann R; Neuss S; Rudolph I; Endermann T; Zasada C; Apostolova I; Gerling M; Kempa S; Hughes R; Lewis CE; Brenner W; Malinowski MB; Stockmann M; Schomburg L; Faller W; Sansom O; Tacke F; Morkel M; Cramer T
Preprint: SSRN ELECTRONIC JOURNAL. 2018

Coordinated Hedgehog Signaling Induces De Novo Hair Follicles in Primed Epithelial Structures

Sun X; Are A; Sivan U; Joost S; Annusver K; Jacob T; Füllgrabe A; Dalessandri T; Gerling M; Kasper M
Corrigendum: NATURE COMMUNICATIONS. 2016;7:12936

Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth (vol 7, 12321, 2016)

Gerling M; Buller NVJA; Kirn LM; Joost S; Frings O; Englert B; Bergstrom A; Kuiper RV; Blaas L; Wielenga MCB; Almer S; Kuhl AA; Fredlund E; van den Brink GR; Toftgard R

Forskningsbidrag

Gerling, Marco – Towards a novel treatment for liver metastases by inhibiting the replacement of healthy cells

Swedish Cancer Society

1 January 2023
Tumor-stroma interactions in liver metastases

Swedish Research Council

1 January 2019 - 31 December 2024
The Role of Hedgehog Signaling for the Interplay between Inflammatory, Epithelial, and Stromal Cells in Colitis-associated Carcinogenesis

Deutsche Forschungsgemeinschaft

1 January 2011 - 31 December 2014

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