Luca Jovine
Om mig
Jag är professor i strukturbiologi och min forskargrupp studerar den molekylära grunden för interaktion mellan ägg och spermier vid befruktning, ett ämne som är direkt relevant för både att förstå mänsklig infertilitet och identifiera potentiella nya metoder för icke-hormonella preventivmedel. Parallellt undersöker vi en uppsättning proteiner som innehåller samma zona pellucida (ZP)-modul som finns i underenheter av äggskal men som utför helt andra biologiska funktioner. Denna del av vårt arbete har implikationer för behandling av urinvägsinfektioner - den vanligaste typen av icke-epidemisk bakterieinfektion hos människor - samt även njur- och kärlsjukdomar.
Mer information om vår forskning kan hittas på min forskargrupps sida (http://jovinelab.org).
Utvalda publikationer
- Article: CELL. 2024;187(6):1440-1459.e24
- Article: NATURE COMMUNICATIONS. 2022;13(1):3880
- Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2022;29(3):190-193
- Article: EMBO JOURNAL. 2020;39(24):e106807
- Article: NATURE COMMUNICATIONS. 2019;10(1):3086
- Article: CELL. 2017;169(7):1315-1326.e17
- Article: CELL REPORTS. 2017;19(9):1917-1928
- Letter: CURRENT BIOLOGY. 2016;26(14):R661-R662
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(6):1552-1557
- Letter: CURRENT BIOLOGY. 2016;26(3):R100-R101
- Article: CELL. 2010;143(3):404-415
- Article: NATURE. 2008;456(7222):653-657
Artiklar
- Article: BLOOD. 2024;143(22):2314-2331
- Article: HUMAN MUTATION. 2024;2024:1-13
- Journal article: ELIFE. 2024;13:RP93131
- Journal article: ELIFE. 2024;13
- Journal article: JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE. 2024;8(s1):129
- Journal article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2023;34(11S):568
- Article: NATURE COMMUNICATIONS. 2023;14(1):3506
- Article: PROTEIN SCIENCE. 2022;31(6):e4333
- Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:872740
- Article: MOLECULAR REPRODUCTION AND DEVELOPMENT. 2021;88(10):686-693
- Article: BLOOD. 2020;136(17):1907-1918
- Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:572735
- Article: SCIENTIFIC REPORTS. 2019;9(1):11601
- Article: IUCRJ. 2019;6(Pt 2):317-330
- Article: SCIENTIFIC REPORTS. 2016;6:32556
- Article: JOURNAL OF STRUCTURAL BIOLOGY. 2016;194(1):1-7
- Article: ELIFE. 2015;4:e08887
- Journal article: REPRODUCTION ABSTRACTS. 2014
- Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2013;69(Pt 12):2563-2579
- Article: MOLECULAR BIOLOGY AND EVOLUTION (MBE). 2012;29(9):2147-2155
- Article: MOLECULAR BIOLOGY AND EVOLUTION (MBE). 2011;28(7):1963-1966
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;370(3):410-413
- Journal article: SOCIETY OF REPRODUCTION AND FERTILITY SUPPLEMENT. 2007;63:187-201
- Article: BMC BIOCHEMISTRY. 2006;7:11
- Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2006;207(1):30-39
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(45):37585-37598
- Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2005;234(1-2):95-103
- Article: BIOCHEMISTRY. 2004;43(23):7459-7478
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(16):5922-5927
- Article: CYTOGENETIC AND GENOME RESEARCH. 2004;105(2-4):228-234
- Journal article: TRENDS IN BIOTECHNOLOGY. 2002;20(12):491-492
- Article: BMC CELL BIOLOGY. 2002;3:28
- Article: MOLECULAR CELL. 2002;9(6):1251-1261
- Article: NATURE CELL BIOLOGY. 2002;4(6):457-461
- Journal article: TRENDS IN BIOTECHNOLOGY. 2002;20(5):190
- Journal article: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2001;12(7):286
- Journal article: TRENDS IN BIOTECHNOLOGY. 2001;19(8):284
- Article: JOURNAL OF MOLECULAR BIOLOGY. 2000;301(2):401-414
- Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2000;56(Pt 8):1033-1037
- Article: JOURNAL OF APPLIED CRYSTALLOGRAPHY. 2000;33(2):988-989
- Article: STRUCTURE. 2000;8(5):527-540
- Article: FEBS LETTERS. 2000;468(1):59-64
- Article: STRUCTURE. 1996;4(5):621-631
- Journal article: GENETICS. 1993;133(2):183-191
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Alla övriga publikationer
- Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024
- Dataset: PDB. 2024
- Dataset: PDB. 2024
- Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:742
- Preprint: ELIFE. 2024
- Preprint: BIORXIV. 2023
- Preprint: BIORXIV. 2023
- Conference publication: ANGIOGENESIS. 2023;26(1):S18
- Preprint: ELSEVIER BV. 2023
- Dataset: PDB. 2022
- Preprint: BIORXIV. 2022
- Preprint: BIORXIV. 2021
- Book chapter: XIIITH INTERNATIONAL SYMPOSIUM ON SPERMATOLOGY. 2021;p. 83-84
- Preprint: BIORXIV. 2020
- Review: MOLECULAR REPRODUCTION AND DEVELOPMENT. 2020;87(3):326-340
- Preprint: SSRN ELECTRONIC JOURNAL. 2020
- Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 2019;75:E13
- Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 2019;75:E135
- Preprint: BIORXIV. 2019
- Review: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 2018;35(3):367-391
- Editorial comment: BASIC AND CLINICAL ANDROLOGY. 2018;28:13
- Review: CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY. 2018;130:413-442
- Dataset: PDB. 2017
- Dataset: PDB. 2017
- Dataset: PDB. 2017
- Dataset: PDB. 2017
- Dataset: PDB. 2016
- Dataset: PDB. 2013
- Dataset: PDB. 2013
- Dataset: PDB. 2013
- Conference publication: THE FEBS JOURNAL. 2012;279:26
- Review: BIOLOGY OF REPRODUCTION. 2011;85(4):661-669
- Editorial comment: MOLECULAR REPRODUCTION AND DEVELOPMENT. 2011;78(1):1
- Letter: JOURNAL OF APPLIED CRYSTALLOGRAPHY. 2008;41:659
- Review: SEMINARS IN REPRODUCTIVE MEDICINE. 2006;24(4):204-216
- Review: ANNUAL REVIEW OF BIOCHEMISTRY. 2005;74:83-114
- Dataset: PDB. 2005
- Published conference paper: EUROPEAN JOURNAL OF OBSTETRICS AND GYNECOLOGY AND REPRODUCTIVE BIOLOGY. 2004;115:S57-S60
- Review: EMBO JOURNAL. 2003;22(14):3479-3485
- Book chapter: GENE EXPRESSION AT THE BEGINNING OF ANIMAL DEVELOPMENT: ADVANCES IN DEVELOPMENTAL BIOLOGY. 2002;p. 31-54
- Editorial comment: TRENDS IN BIOTECHNOLOGY. 2001;19(12):487-488
- Review: NATURE CELL BIOLOGY. 2001;3(2):E59-E64
- Corrigendum: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2000;56(# (Pt 11)):1512
- Corrigendum: JOURNAL OF MOLECULAR BIOLOGY. 2000;303(1):113
- Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 1996;52:C163
- Dataset:
- Preprint:Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy
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Forskningsbidrag
- Utnyttja integrativa strukturbiologiska upptäckter för att reda ut viktiga molekylära interaktioner i befruktning och antibakteriellt försvarVetenskapsrådet1 January 2025 - 31 December 2028
- Swedish Research Council1 January 2021 - 31 December 2024
- Deutsche Forschungsgemeinschaft1 January 2018 - 31 December 2019
- Deutsche Forschungsgemeinschaft1 January 2018 - 31 December 2019
- Knut and Alice Wallenberg Foundation1 January 2018 - 1 January 2023
- Swedish Research Council1 January 2017 - 31 December 2020
- Egg-sperm interaction at fertilization and Hedgehog (Hh) signalingCenter for Innovative Medicine (CIMED)1 January 2015 - 31 December 2019
- Japan Society for the Promotion of Science1 April 2013 - 31 March 2016
- Molecular Basis of Mammalian Egg-Sperm Interaction at FertilizationGöran Gustafssons Stiftelse1 January 2013 - 31 December 2015
- Swedish Research Council1 January 2013 - 31 December 2016
- Swedish Research Council1 January 2013 - 31 December 2016
- European Research Council1 January 2011 - 31 December 2015
- Molecular basis of mammalian egg-sperm recognitionEuropean Molecular Biology Organization4 July 2010 - 4 July 2012
- Swedish Research Council1 January 2010 - 31 December 2012
- EMBO Young Investigators Award 2009Swedish Research Council1 January 2010 - 31 December 2012
- Swedish Research Council1 January 2010 - 31 December 2012
- Structural studies of zona pellucida domain proteinsSwedish Research Council1 January 2008 - 31 December 2009
- Cordis1 April 2006 - 31 March 2007
- Structural studies of zona pellucida domain proteinsSwedish Research Council1 January 2006 - 31 December 2007
- Structural studies of mammalian fertilisation proteinsInternational Human Frontier Science Program Organization1 May 2001 - 30 April 2004
Anställningar
- Professor, Medicin, Huddinge, Karolinska Institutet, 2024-
- Professor, Institutionen för biovetenskaper och näringslära, Karolinska Institutet, 2013-2024
- Senior Forskare, Institutionen för biovetenskaper och näringslära, Karolinska Institutet, 2005-2013
Examina och utbildning
- Ph.D, MRC Laboratory of Molecular Biology, University of Cambridge, 2000
Priser och utmärkelser
- Knut och Alice Wallenbergs Stiftelse Stipendium, Knut and Alice Wallenberg Foundation, 2019
- Center for Innovative Medicine Senior Investigator Grant, Karolinska Institute, 2015
- Hugo Theorell Prize for Biophysics, Svenska Föreningen för Biokemi, Biofysik och Molekylärbiologi, 2013
- Göran Gustafsson Prize for Chemistry, Göran Gustafsson Foundation, 2012
- Erik K. Fernström Prize, Fernströmstiftelsen, 2011
- ERC Starting Grant, European Union, 2011
- EMBO Young Investigator, European Molecular Biology Organization, 2010
- Sven och Ebba-Christina Hagberg Prize for Medical Research, Sven and Ebba-Christina Hagberg Foundation, 2010
- Human Frontier Science Program Long-Term Fellow, International Human Frontier Science Program Organization, 2001
- EMBO Long-Term Fellow, European Molecular Biology Organization, 2001
Uppdrag i kommitté
- Medlem, ClinGen HHT: Hereditary Hemorrhagic Telangiectasia Variant Curation Expert Panel, National Institutes of Health, https://www.clinicalgenome.org/affiliation/50037/, 2019-
- Medlem, Nobelförsamlingen vid Karolinska Institutet, Karolinska Institute, https://www.nobelprizemedicine.org/selecting-laureates/the-nobel-assembly, 2019-
- Medlem, EMBO, European Molecular Biology Organization, https://people.embo.org/profile/luca-jovine, 2019-
Gästforskning och resestipendier
- Postdoktor, Icahn School of Medicine at Mount Sinai, New York, 2000-2005