Luca Jovine

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Jag är professor i strukturbiologi och min forskargrupp studerar den molekylära grunden för interaktion mellan ägg och spermier vid befruktning, ett ämne som är direkt relevant för både att förstå mänsklig infertilitet och identifiera potentiella nya metoder för icke-hormonella preventivmedel. Parallellt undersöker vi en uppsättning proteiner som innehåller samma zona pellucida (ZP)-modul som finns i underenheter av äggskal men som utför helt andra biologiska funktioner. Denna del av vårt arbete har implikationer för behandling av urinvägsinfektioner - den vanligaste typen av icke-epidemisk bakterieinfektion hos människor - samt även njur- och kärlsjukdomar.

Mer information om vår forskning kan hittas på min forskargrupps sida (http://jovinelab.org).

Utvalda publikationer

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2025;122(15):e2426057122
Structural basis of ZP2-targeted female nonhormonal contraception
Dioguardi E; Stsiapanava A; Fahrenkamp E; Han L; de Sanctis D; Inzunza J; Jovine L
Article: CELL. 2024;187(6):1440-1459.e24
ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat
Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Algarra B; Lu Y; Kodani M; Bainbridge RE; Komondor KM; Carlson AE; Landreh M; Sanctis DD; Yasumasu S; Ikawa M; Jovine L
Article: NATURE COMMUNICATIONS. 2022;13(1):3880
Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins
Moi D; Nishio S; Li X; Valansi C; Langleib M; Brukman NG; Flyak K; Dessimoz C; de Sanctis D; Tunyasuvunakool K; Jumper J; Grana M; Romero H; Aguilar PS; Jovine L; Podbilewicz B
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2022;29(3):190-193
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH
Stsiapanava A; Xu C; Nishio S; Han L; Yamakawa N; Carroni M; Tunyasuvunakool K; Jumper J; de Sanctis D; Wu B; Jovine L
Article: EMBO JOURNAL. 2020;39(24):e106807
Cryo-EM structure of native human uromodulin, a zona pellucida module polymer
Stsiapanava A; Xu C; Brunati M; Zamora-Caballero S; Schaeffer C; Bokhove M; Han L; Hebert H; Carroni M; Yasumasu S; Rampoldi L; Wu B; Jovine L
Article: NATURE COMMUNICATIONS. 2019;10(1):3086
Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
Nishimura K; Dioguardi E; Nishio S; Villa A; Han L; Matsuda T; Jovine L
Article: CELL. 2017;169(7):1315-1326.e17
Structural Basis of Egg Coat-Sperm Recognition at Fertilization
Raj I; Al Hosseini HS; Dioguardi E; Nishimura K; Han L; Villa A; de Sanctis D; Jovine L
Article: CELL REPORTS. 2017;19(9):1917-1928
Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1
Saito T; Bokhove M; Croci R; Zamora-Caballero S; Han L; Letarte M; de Sanctis D; Jovine L
Letter: CURRENT BIOLOGY. 2016;26(14):R661-R662
The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins
Nishimura K; Han L; Bianchi E; Wright GJ; de Sanctis D; Jovine L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(6):1552-1557
A structured interdomain linker directs self-polymerization of human uromodulin
Bokhove M; Nishimura K; Brunati M; Han L; de Sanctis D; Rampoldi L; Jovine L
Letter: CURRENT BIOLOGY. 2016;26(3):R100-R101
Divergent evolution of vitamin B₉ binding underlies Juno-mediated adhesion of mammalian gametes
Han L; Nishimura K; Al Hosseini HS; Bianchi E; Wright GJ; Jovine L
Article: CELL. 2010;143(3):404-415
Insights into Egg Coat Assembly and Egg-Sperm Interaction from the X-Ray Structure of Full-Length ZP3
Han L; Monne M; Okumura H; Schwend T; Cherry AL; Flot D; Matsuda T; Jovine L
Article: NATURE. 2008;456(7222):653-657
Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats
Monne M; Han L; Schwend T; Burendahl S; Jovine L

Artiklar

Article: COMMUNICATIONS BIOLOGY. 2025;8(1):316
Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia
El Hamaoui D; Marchelli A; Gandrille S; Reboul E; Stepanian A; Palmier B; Jovine L; Lebrin F; Smadja DM; Bernabeu C; Denis CV; Gaussem P; Pasquali S; Kauskot A; Rossi E
Article: BLOOD. 2024;143(22):2314-2331
Mutations causing premature termination codons discriminate and generate cellular and clinical variability in HHT
Bernabeu-Herrero ME; Patel D; Bielowka A; Zhu J; Jain K; Mackay IS; Guerrero PC; Emanuelli G; Jovine L; Noseda M; Marciniak SJ; Aldred MA; Shovlin CL
Article: HUMAN MUTATION. 2024;2024:1-13
Specifications of the ACMG/AMP Variant Curation Guidelines for Hereditary Hemorrhagic Telangiectasia Genes-ENG and ACVRL1
DeMille D; McDonald J; Bernabeu C; Racher H; Olivieri C; Cantarini C; Sbalchiero A; Thompson BA; Jovine L; Shovlin CL; Dupuis-Girod S; Lesca G; Tusseau M; Ganguly A; Kasthuri RS; Jessen J; Massink MPG; Ichikawa S; Bayrak-Toydemir P
Journal article: ELIFE. 2024;13
Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse
Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
Journal article: ELIFE. 2024;13:RP93131
Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse.
Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
Journal article: JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE. 2024;8(s1):129
431 Defective uromodulin polymerization and peptide excretion in a natural canine model of kidney stones
Furrow E; Rampoldi L; Jovine L; Wesson JA; Treeful AE; Jayachandran M; Lieske JC; Romero MF; Lulich JP
Journal article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2023;34(11S):568
A Canine Model Implicates Uromodulin Peptides in Calcium Oxalate Urinary Stone Risk
Furrow E; Rampoldi L; Jovine L; Wesson J; Jayachandran M; Lieske JC; Romero MF; Lulich JP
Article: NATURE COMMUNICATIONS. 2023;14(1):3506
Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries
Gert KRB; Panser K; Surm J; Steinmetz BS; Schleiffer A; Jovine L; Moran Y; Kondrashov F; Pauli A
Article: PROTEIN SCIENCE. 2022;31(6):e4333
Complementing machine learning-based structure predictions with native mass spectrometry
Allison TM; Degiacomi MT; Marklund EG; Jovine L; Elofsson A; Benesch JLP; Landreh M
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:872740
A Non-Synonymous Point Mutation in a WD-40 Domain Repeat of EML5 Leads to Decreased Bovine Sperm Quality and Fertility
Nogueira E; Tirpak F; Hamilton LE; Zigo M; Kerns K; Sutovsky M; Kim J; Volkmann D; Jovine L; Taylor JF; Schnabel RD; Sutovsky P
Article: MOLECULAR REPRODUCTION AND DEVELOPMENT. 2021;88(10):686-693
Using machine learning to study protein-protein interactions: From the uromodulin polymer to egg zona pellucida filaments
Jovine L
Article: BLOOD. 2020;136(17):1907-1918
Mutational and phenotypic characterization of hereditary hemorrhagic telangiectasia
Shovlin CL; Simeoni I; Downes K; Frazer ZC; Megy K; Bernabeu-Herrero ME; Shurr A; Brimley J; Patel D; Kell L; Stephens J; Turbin IG; Aldred MA; Penkett CJ; Ouwehand WH; Jovine L; Turro E
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:572735
Molecular Mechanism Underlying the Action ofZona-pellucidaGlycoproteins on Mouse Sperm
Balbach M; Hamzeh H; Jikeli JF; Brenker C; Schiffer C; Hansen JN; Neugebauer P; Troetschel C; Jovine L; Han L; Florman HM; Kaupp UB; Struenker T; Wachten D
Article: SCIENTIFIC REPORTS. 2019;9(1):11601
Autosomal Dominant Tubulointerstitial Kidney Disease with Adult Onset due to a Novel Renin Mutation Mapping in the Mature Protein
Schaeffer C; Izzi C; Vettori A; Pasqualetto E; Cittaro D; Lazarevic D; Caridi G; Gnutti B; Mazza C; Jovine L; Scolari F; Rampoldi L
Article: GENE. 2019;696:33-39
Characterization of a mutation in the zona pellucida module of Endoglin that causes Hereditary Hemorrhagic Telangiectasia
Ruiz-Llorente L; Chiapparino E; Plumitallo S; Danesino C; Bayrak-Toydemir P; Pagella F; Manfredi G; Bernabeu C; Jovine L; Olivieri C
Article: IUCRJ. 2019;6(Pt 2):317-330
Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition
Cuppari A; Koerschgen H; Fahrenkamp D; Schmitz C; Guevara T; Karmilin K; Kuske M; Olf M; Dietzel E; Yiallouros I; de Sanctis D; Goulas T; Weiskirchen R; Jahnen-Dechent W; Floehr J; Stoecker W; Jovine L; Gomis-Rueth FX
Article: SCIENTIFIC REPORTS. 2016;6:32556
The C-terminal region of OVGP1 remodels the zona pellucida and modifies fertility parameters
Algarra B; Han L; Soriano-Ubeda C; Aviles M; Coy P; Jovine L; Jimenez-Movilla M
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2016;194(1):1-7
Easy mammalian expression and crystallography of maltose-binding protein-fused human proteins
Bokhove M; Al Hosseini HS; Saito T; Dioguardi E; Gegenschatz-Schmid K; Nishimura K; Raj I; de Sanctis D; Han L; Jovine L
Article: ELIFE. 2015;4:e08887
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin
Brunati M; Perucca S; Han L; Cattaneo A; Consolato F; Andolfo A; Schaeffer C; Olinger E; Peng J; Santambrogio S; Perrier R; Li S; Bokhove M; Bachi A; Hummler E; Devuyst O; Wu Q; Jovine L; Rampoldi L
Journal article: REPRODUCTION ABSTRACTS. 2014
Deletion of the C-terminal region of OVGP1 affects porcine IVF
Algarra B; Han L; Aviles M; Coy P; Jovine L; Jimenez-Movilla M
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2013;69(Pt 12):2563-2579
Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation
Cherry AL; Finta C; Karlstrom M; Jin Q; Schwend T; Astorga-Wells J; Zubarev RA; Del Campo M; Criswell AR; de Sanctis D; Jovine L; Toftgard R
Article: MOLECULAR BIOLOGY AND EVOLUTION. 2012;29(9):2147-2155
Evolution of the Voltage Sensor Domain of the Voltage-Sensitive Phosphoinositide Phosphatase VSP/TPTE Suggests a Role as a Proton Channel in Eutherian Mammals
Sutton KA; Jungnickel MK; Jovine L; Florman HM
Article: MOLECULAR BIOLOGY AND EVOLUTION. 2011;28(7):1963-1966
The Molecular Basis of Sex: Linking Yeast to Human
Swanson WJ; Aagaard JE; Vacquier VD; Monne M; Al Hosseini HS; Jovine L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;370(3):410-413
Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage
Santambrogio S; Cattaneo A; Bernascone I; Schwend T; Jovine L; Bachi A; Rampoldi L
Journal article: SOCIETY OF REPRODUCTION AND FERTILITY SUPPLEMENT. 2007;63:187-201
Features that affect secretion and assembly of zona pellucida glycoproteins during mammalian oogenesis.
Jovine L; Qi H; Williams Z; Litscher ES; Wassarman PM
Article: BMC BIOCHEMISTRY. 2006;7:11
The PLAC1-homology region of the ZP domain is sufficient for protein polymerisation.
Jovine L; Janssen WG; Litscher ES; Wassarman PM
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2006;207(1):30-39
Polypeptide encoded by mouse ZP3 exon-7 is necessary and sufficient for binding of mouse sperm in vitro
Williams Z; Litscher ES; Jovine L; Wassarman PM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(45):37585-37598
Mass spectrometric evidence that proteolytic processing of rainbow trout egg vitelline envelope proteins takes place on the egg
Darie CC; Biniossek ML; Gawinowicz MA; Milgrom Y; Thumfart JO; Jovine L; Litscher ES; Wassarman PM
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2005;234(1-2):95-103
Recent aspects of mammalian fertilization research
Wassarman PM; Jovine L; Qi HY; Williams Z; Darie C; Litscher ES
Article: BIOCHEMISTRY. 2004;43(23):7459-7478
Structural characterization of fish egg vitelline envelope proteins by mass spectrometry
Darie CC; Biniossek ML; Jovine L; Litscher ES; Wassarman PM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(16):5922-5927
A duplicated motif controls assembly of zona pellucida domain proteins
Jovine L; Qi HY; Williams Z; Litscher ES; Wassarman PM
Article: CYTOGENETIC AND GENOME RESEARCH. 2004;105(2-4):228-234
Mouse zona pellucida genes and glycoproteins
Wassarman PM; Jovine L; Litscher ES
Journal article: TRENDS IN BIOTECHNOLOGY. 2002;20(12):491-492
Macromolecular mimicry in protein synthesis: beware of imitations
Jovine L
Article: BMC CELL BIOLOGY. 2002;3:28
Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear
Jovine L; Park J; Wassarman PM
Article: MOLECULAR CELL. 2002;9(6):1251-1261
Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle
Oubridge C; Kuglstatter A; Jovine L; Nagai K
Article: NATURE CELL BIOLOGY. 2002;4(6):457-461
The ZP domain is a conserved module for polymerization of extracellular proteins
Jovine L; Qi HY; Williams Z; Litscher E; Wassarman PM
Journal article: TRENDS IN BIOTECHNOLOGY. 2002;20(5):190
Molecular beacons meet DNA–protein interactions: bye bye bandshift?
Jovine L
Journal article: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2001;12(7):286
Heavier weight on tubby
Jovine L
Journal article: TRENDS IN BIOTECHNOLOGY. 2001;19(8):284
Heavier weight on tubby
Jovine L
Article: JOURNAL OF MOLECULAR BIOLOGY. 2000;301(2):401-414
The crystal structure of yeast phenylalanine tRNA at 2.0 Å resolution:: Cleavage by Mg²⁺ in 15-year old crystals
Jovine L; Djordjevic S; Rhodes D
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2000;56(Pt 8):1033-1037
Crystallization and preliminary X-ray analysis of the conserved domain IV of Escherichia coli 4.5S RNA
Jovine L; Hainz T; Oubridge C; Nagai K
Article: JOURNAL OF APPLIED CRYSTALLOGRAPHY. 2000;33(2):988-989
A simple technique to control macromolecular crystal nucleation efficiently using a standard vapour-diffusion setup
Jovine L
Article: STRUCTURE. 2000;8(5):527-540
Crystal structure of the Ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA
Jovine L; Hainzl T; Oubridge C; Scott WG; Li J; Sixma TK; Wonacott A; Skarzynski T; Nagai K
Article: FEBS LETTERS. 2000;468(1):59-64
The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region
Acquati F; Accarino M; Nucci C; Fumagalli P; Jovine L; Ottolenghi S; Taramelli R
Article: STRUCTURE. 1996;4(5):621-631
Two structurally different RNA molecules are bound by the spliceosomal protein U1A using the same recognition strategy
Jovine L; Oubridge C; Avis JM; Nagai K
Journal article: GENETICS. 1993;133(2):183-191
CONDITIONAL MUTATIONS IN THE YEAST DNA PRIMASE GENES AFFECT DIFFERENT ASPECTS OF DNA METABOLISM AND INTERACTIONS IN THE DNA-POLYMERASE ALPHA-PRIMASE COMPLEX
LONGHESE MP; JOVINE L; PLEVANI P; LUCCHINI G
Visa fler

Alla övriga publikationer

Dataset: PDB. 2025
Structure of fertilization-blocking monoclonal antibody IE-3 VHVL bound to the ZP-N1 domain of mouse ZP2 (crystal form I)
Jovine L
Dataset: PDB. 2025
Structure of fertilization-blocking monoclonal antibody IE-3 VHVL bound to the ZP-N1 domain of mouse ZP2 (crystal form II)
Jovine L
Preprint: BIORXIV. 2025
Structural basis of ZP2-targeted immunocontraception
Dioguardi E; Stsiapanava A; Fahrenkamp E; Han L; de Sanctis D; Inzunza J; Jovine L
Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024
Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse
Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
Dataset: PDB. 2024
Crystal structure of the complete N-terminal region of human ZP2 (hZP2-N1N2N3)
Jovine L
Dataset: PDB. 2024
Crystal structure of the ZP-N1 and ZP-N2 domains of human ZP2 (hZP2-N1N2)
Jovine L
Dataset: PDB. 2024
Crystal structure of tetrameric collagenase-cleaved Xenopus ZP2-N2N3 (cleaved xZP2-N2N3)
Jovine L
Dataset: PDB. 2024
Crystal structure of the ZP-N2 and ZP-N3 domains of mouse ZP2 (mZP2-N2N3)
Jovine L
Dataset: PDB. 2024
Molecular basis of ZP3/ZP1 heteropolymerization: crystal structure of a native vertebrate egg coat filament fragment
Jovine L
Dataset: PDB. 2024
Molecular basis of ZP3/ZP1 heteropolymerization: crystal structure of a native vertebrate egg coat filament
Jovine L
Dataset: EMDB. 2024
Cryo-EM of tetrameric collagenase-cleaved Xenopus ZP2-N2N3 (cleaved xZP2-N2N3) (C1)
Jovine L
Dataset: EMDB. 2024
Cryo-EM of tetrameric collagenase-cleaved Xenopus ZP2-N2N3 (cleaved xZP2-N2N3) (C2)
Jovine L
Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024
Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse
Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:742
ClinGen HHT Variant Curation Expert Panel's modified variant interpretation and classification guidelines
Demille D; Sbalchiero A; Cantarini C; Thompson B; McDonald J; Bernabeu C; Dupuis-Girod S; Ganguly A; Giraud S; Ichikawa S; Jessen J; Jovine L; Kasthuri R; Olivieri C; van Amstel JKP; Racher H; Shovlin C; Bayrak-Toydemir P
Preprint: ELIFE. 2024
Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse
Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
Preprint: BIORXIV. 2023
Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse
Elofsson A; Han L; Bianchi E; Wright G; Jovine L
Preprint: BIORXIV. 2023
Architecture of the vertebrate egg coat and structural basis of the ZP2 block to polyspermy
Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Lu Y; Kodani M; Bainbridge R; Komondor K; Carlson A; Landreh M; de Sanctis D; Yasumasu S; Ikawa M; Jovine L
Preprint: ELSEVIER BV. 2023
Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy
Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Lu Y; Kodani M; Bainbridge RE; Komondor KM; Carlson AE; Landreh M; Daniele DS; Yasumasu S; Ikawa M; Jovine L
Conference publication: ANGIOGENESIS. 2023;26(1):S18
ClinGen HHT Variant Curation Expert Panel's Modified Variant Interpretation and Classification Guidelines
DeMille D; McDonald J; Bernabeu C; Dupuis-Girod S; Ganguly A; Giraud S; Ichikawa S; Jessen J; Jovine L; Kasthuri RS; Olivieri C; van Amstel PHK; Racher H; Shovlin CL; Bayrak-Toydemir P
Conference publication: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2023;34(11):568
A Canine Model Implicates Uromodulin Peptides in Calcium Oxalate Urinary Stone Risk
Furrow E; Rampoldi L; Jovine L; Wesson J; Jayachandran M; Lieske JC; Romero MF; Lulich JP
Dataset: PDB. 2022
Crystal structure of the trimeric ectodomain of archaeal Fusexin1 (Fsx1)
Jovine L; Nishio S; Tunyasuvunakool K; Jumper J; De Sanctis D
Preprint: BIORXIV. 2022
Complementing machine learning-based structure predictions with native mass spectrometry
Allison TM; Degiacomi MT; Marklund EG; Jovine L; Elofsson A; Benesch JLP; Landreh M
Dataset: PDB. 2022
Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament
Jovine L; Xu C; Stsiapanava A; Carroni M; Tunyasuvunakool K; Jumper J
Dataset: PDB. 2022
Cryo-EM of the complex between human uromodulin (UMOD)/Tamm-Horsfall protein (THP) and the FimH lectin domain from uropathogenic E. coli
Jovine L
Dataset: PDB. 2022
Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form I)
Jovine L
Dataset: PDB. 2022
Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form II)
Jovine L
Dataset: 2022
Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form III)
Jovine L
Preprint: BIORXIV. 2021
Discovery of archaeal Fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins
Moi D; Nishio S; Li X; Valansi C; Langleib M; Brukman NG; Flyak K; Dessimoz C; de Sanctis D; Tunyasuvunakool K; Jumper J; Graña M; Romero H; Aguilar PS; Jovine L; Podbilewicz B
Book chapter: XIIITH INTERNATIONAL SYMPOSIUM ON SPERMATOLOGY. 2021;p. 83-84
First Snapshot of How Sperm Binds the Egg at the Molecular Level
Jovine L
Dataset: PDB. 2020
Cryo-EM of native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament
Jovine L; Stsiapanava A; Xu C; Carroni M; Wu B
Dataset: PDB. 2020
Cryo-EM of elastase-treated human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament
Jovine L; Stsiapanava A; Xu C; Carroni M; Wu B
Preprint: BIORXIV. 2020
Cryo-EM Structure of Native Human Uromodulin, a Zona Pellucida Module Polymer
Stsiapanava A; Xu C; Brunati M; Zamora-Caballero S; Schaeffer C; Han L; Carroni M; Yasumasu S; Rampoldi L; Wu B; Jovine L
Review: MOLECULAR REPRODUCTION AND DEVELOPMENT. 2020;87(3):326-340
Mammalian egg coat modifications and the block to polyspermy
Fahrenkamp E; Algarra B; Jovine L
Preprint: SSRN ELECTRONIC JOURNAL. 2020
Cryo-EM Structure of Native Human Uromodulin, a Zona Pellucida Module Polymer
Stsiapanava A; Xu C; Brunati M; Zamora-Caballero S; Schaeffer C; Han L; Carroni M; Yasumasu S; Rampoldi L; Wu B; Jovine L
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2019;75:E13
FERTILIZATION AT THE ATOMIC LEVEL - MARRYING BASIC SCIENCE AND REPRODUCTIVE MEDICINE
Jovine L
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2019;75:E135
SELECTIVE INHIBITION OF ASTACIN METALLOPEPTIDASES BY MAMMALIAN FETUIN-B
Cuppari A; Koerschgen H; Fahrenkamp D; Schmitz C; Jahnen-Dechent W; Stoeker W; Jovine L; Gomis-Ruth FX
Dataset: PDB. 2019
Molecular basis of egg coat filament cross-linking: high-resolution structure of the partially deglycosylated ZP1 ZP-N1 domain homodimer
Jovine L
Dataset: PDB. 2019
Molecular basis of egg coat filament cross-linking: Zn-SAD structure of the partially deglycosylated ZP1 ZP-N1 domain homodimer
Jovine L
Dataset: PDB. 2019
Molecular basis of egg coat filament cross-linking: structure of the glycosylated ZP1 ZP-N1 domain homodimer
Jovine L
Preprint: BIORXIV. 2019
Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
Nishimura K; Dioguardi E; Nishio S; Villa A; Han L; Matsuda T; Jovine L
Dataset: 2019
Crystal structure of mouse fetuin-B
Fahrenkamp D; Dietzel E; de Sanctis D; Jovine L
Review: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 2018;35(3):367-391
Revisiting embryo assisted hatching approaches: a systematic review of the current protocols
Alteri A; Vigano P; Abu Maizar A; Jovine L; Giacomini E; Rubino P
Review: CELLULAR NETWORKS IN DEVELOPMENT. 2018;130:413-442
Structure of Zona Pellucida Module Proteins
Bokhove M; Jovine L
Other: BASIC AND CLINICAL ANDROLOGY. 2018;28:13
Male reproductive health statement (XIIIth international symposium on Spermatology, may 9th-12th 2018, Stockholm, Sweden
Levine H; Mohri H; Ekbom A; Ramos L; Parker G; Roldan E; Jovine L; Koelle S; Lindstrand A; Immler S; Mortimer S; Mortimer D; van der Horst G; Ishijima S; Aneck-Hahn N; Baldi E; Menkveld R; Rothmann SA; Giwercman A; Giwercman Y; Holmberg M; Kvist U; Bjorndahl L; Holmberg R; Arver S; Flanagan J; Drevet JR
Dataset: 2017
ZP-N domain of mammalian sperm receptor ZP3 (crystal form II, processed in P21221)
Jovine L; Monne M
Dataset: PDB. 2017
Crystal structure of red abalone VERL repeat 1 with linker at 2.0 A resolution
Jovine L
Dataset: PDB. 2017
Crystal structure of red abalone VERL repeat 1 at 1.8 A resolution
Jovine L
Dataset: PDB. 2017
In-house sulfur-SAD structure of orthorhombic red abalone lysin at 1.66 A resolution
Jovine L
Dataset: PDB. 2017
Orthorhombic crystal structure of red abalone lysin at 0.99 A resolution
Jovine L
Dataset: PDB. 2017
Monoclinic crystal structure of red abalone lysin at 2.11 A resolution
Jovine L
Dataset: PDB. 2017
Crystal structure of red abalone egg VERL repeat 3 in complex with sperm lysin at 1.7 A resolution (crystal form I)
Jovine L
Dataset: PDB. 2017
Crystal structure of red abalone egg VERL repeat 3 in complex with sperm lysin at 1.64 A resolution (crystal form II)
Jovine L
Dataset: PDB. 2017
Crystal structure of red abalone VERL repeat 3 at 2.9 A resolution
Jovine L
Dataset: PDB. 2017
Crystal structure of red abalone VERL repeat 2 with linker at 2.5 A resolution
Jovine L
Dataset: 2017
Crystal structure of red abalone egg VERL repeat 2 with linker in complex with sperm lysin at 1.8 A resolution
Jovine L
Dataset: PDB. 2017
Crystal structure of the orphan region of human endoglin/CD105 in complex with BMP9
Jovine L
Dataset: 2017
Crystal structure of the orphan region of human endoglin/CD105
Saito T; Bokhove M; de Sanctis D; Jovine L
Dataset: 2017
Crystal structure of the zona pellucida module of human endoglin/CD105
Bokhove M; Saito T; Jovine L
Dataset: PDB. 2016
Crystal structure of Izumo1, the mammalian sperm ligand for egg Juno
Jovine L
Dataset: 2016
Crystal structure of the ZP-C domain of mouse ZP2
Nishimura K; Jovine L
Dataset: PDB. 2013
Crystal structure of full-length human Suppressor of fused (SUFU)
Jovine L; Toftgård R
Dataset: PDB. 2013
Crystal structure of full-length human Suppressor of fused (SUFU) mutant lacking a regulatory subdomain (crystal form I)
Jovine L; Toftgård R
Dataset: PDB. 2013
Crystal structure of a human Suppressor of fused (SUFU)-GLI3p complex
Jovine L; Toftgård R
Dataset: PDB. 2013
Crystal structure of full-length human Suppressor of fused (SUFU) mutant lacking a regulatory subdomain (crystal form II)
Jovine L; Toftgård R
Dataset: PDB. 2013
Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex
Jovine L; Toftgård R
Conference publication: FEBS JOURNAL. 2012;279:26
Hedgehog signalling and cancer initiation
Toftgard R; Finta C; Cherry A; Fullgrabe A; Kasper M; Jovine L
Review: BIOLOGY OF REPRODUCTION. 2011;85(4):661-669
A Structural View of Egg Coat Architecture and Function in Fertilization
Monne M; Jovine L
Editorial comment: MOLECULAR REPRODUCTION AND DEVELOPMENT. 2011;78(1):1
X-ray of fertilization
Jovine L
Dataset: 2010
Crystal structure of full-length sperm receptor ZP3 at 2.6 A resolution
Monne M; Jovine L
Dataset: 2008
ZP-N domain of mammalian sperm receptor ZP3 (crystal form III)
Monne M; Jovine L
Dataset: 2008
ZP-N domain of mammalian sperm receptor ZP3 (crystal form II)
Jovine L; Monne M
Letter: JOURNAL OF APPLIED CRYSTALLOGRAPHY. 2008;41:659
Of crystals, structure factors and diffraction images
Jovine L; Morgunova E; Ladenstein R
Review: SEMINARS IN REPRODUCTIVE MEDICINE. 2006;24(4):204-216
Tracking down the ZP domain:: From the mammalian zona pellucida to the molluscan vitelline envelope
Monne M; Han L; Jovine L
Review: ANNUAL REVIEW OF BIOCHEMISTRY. 2005;74:83-114
Zona pellucida domain proteins
Jovine L; Darie CC; Litscher ES; Wassarman PM
Dataset: PDB. 2005
CRYSTAL STRUCTURE OF THE CONSERVED DOMAIN IV OF E. COLI 4.5S RNA
Nagai K
Published conference paper: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY. 2004;115:S57-S60
Egg-sperm interactions at fertilization in mammals
Wassarman PA; Jovine L; Litscher ES; Qi HY; Williams Z
Review: EMBO JOURNAL. 2003;22(14):3479-3485
Structure, function and evolution of the signal recognition particle
Nagai K; Oubridge C; Kuglstatter A; Menichelli E; Isel C; Jovine L
Dataset: PDB. 2002
CRYSTAL STRUCTURE OF SRP19 IN COMPLEX WITH THE S DOMAIN OF SIGNAL RECOGNITION PARTICLE RNA
Nagai K
Book chapter: GENE EXPRESSION AT THE BEGINNING OF ANIMAL DEVELOPMENT: ADVANCES IN DEVELOPMENTAL BIOLOGY. 2002;p. 31-54
Egg zona pellucida, egg vitelline envelope, and related extracellular glycoproteins
Jovine L; Litscher ES; Wassarman PM
Editorial comment: TRENDS IN BIOTECHNOLOGY. 2001;19(12):487-488
New molecular beacons for targeting double-stranded DNA under native conditions
Jovine L
Review: NATURE CELL BIOLOGY. 2001;3(2):E59-E64
A profile of fertilization in mammals
Wassarman PM; Jovine L; Litscher ES
Corrigendum: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2000;56(# (Pt 11)):1512
Crystallization and preliminary X-ray analysis of the conserved domain IV of Escherichia coli 4.5S RNA (vol D56, pg 1033, 2000)
Jovine L; Hainzl T; Oubridge C; Nagai K
Corrigendum: JOURNAL OF MOLECULAR BIOLOGY. 2000;303(1):113
The crystal structure of yeast phenylalanine tRNA at 2.0 Å resolution:: Cleavage by Mg²⁺ in 15-year old crystals (vol 301, pg 401, 2000)
Jovine L; Djordjevic S; Rhodes D
Dataset: 2000
CRYSTAL STRUCTURE OF YEAST PHENYLALANINE TRANSFER RNA AT 2.0 A RESOLUTION
Jovine L; Djordjevic S; Rhodes D
Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 1996;52:C163
U1A SPLICEOSOMAL PROTEIN BINDS TO TWO DIFFERENT RNA TARGETS USING THE SAME STRATEGY
Nagai K; Oubridge O; Price S; Jovine L; Avis J; Evans PR
Preprint:
Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy
Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Lu Y; Kodani M; Bainbridge RE; Komondor KM; Carlson AE; Landreh M; Daniele DS; Yasumasu S; Ikawa M; Jovine L
Dataset:
Crystal structure of full-length sperm receptor ZP3 at 2.0 A resolution
Monne M; Jovine L
Dataset:
ZP-N domain of mammalian sperm receptor ZP3 (crystal form I)
Jovine L; Monne M
Dataset:
HUMAN U1A/U1A PRE-MRNA 3'UTR COMPLEX (THEORETICAL MODEL)
Jovine L; Oubridge C; Avis JM; Nagai K
Dataset:
Crystal structure of the polymerization region of human uromodulin/Tamm-Horsfall protein
Bokhove M; De Sanctis D; Jovine L
Dataset:
Crystal structure of human BMP9 at 1.87 A resolution
Saito T; Bokhove M; Jovine L
Dataset:
Crystal structure of the ZP-N1 domain of mouse sperm receptor ZP2 at 0.95 A resolution
Dioguardi E; Han L; Nishimura K; De Sanctis D; Jovine L
Dataset:
Crystal structure of Juno, the mammalian egg receptor for sperm Izumo1
Nishimura K; Han L; Jovine L
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Forskningsbidrag

Utnyttja integrativa strukturbiologiska upptäckter för att reda ut viktiga molekylära interaktioner i befruktning och antibakteriellt försvar
Vetenskapsrådet
1 January 2025 - 31 December 2028
Combining X-rays and electrons to shed light on fertilization and antibacterial defense
Swedish Research Council
1 January 2021 - 31 December 2024
Integrative Structural Biology of Mammalian Fertilization: Unveiling the Beginning of Life from Gametes to Atoms
Knut and Alice Wallenberg Foundation
1 January 2018 - 1 January 2023
Breaking the egg coat twice: sperm penetration and embryo hatching
Deutsche Forschungsgemeinschaft
1 January 2018 - 31 December 2019
Hard or Die: Molecular Principles of Zona pellucida hardening
Deutsche Forschungsgemeinschaft
1 January 2018 - 31 December 2019
Structural studies of protein complexes in fertilization, antibacterial defense and cancer
Swedish Research Council
1 January 2017 - 31 December 2020
Egg-sperm interaction at fertilization and Hedgehog (Hh) signaling
Center for Innovative Medicine (CIMED)
1 January 2015 - 31 December 2019
Investigations of molecular mechanisms of the egg-coat formation and egg-sperm interaction involved in gamete recognition
Japan Society for the Promotion of Science
1 April 2013 - 31 March 2016
Structural Studies of Fertilization and Human Hedgehog Signaling Proteins
Swedish Research Council
1 January 2013 - 31 December 2016
Molecular and biochemical analysis of Hedgehog signaling and characterization of epithelial skin stem cells.
Swedish Research Council
1 January 2013 - 31 December 2016
Molecular Basis of Mammalian Egg-Sperm Interaction at Fertilization
Göran Gustafssons Stiftelse
1 January 2013 - 31 December 2015
Molecular Basis of Mammalian Egg-Sperm Interaction
European Research Council
1 January 2011 - 31 December 2015
Molecular basis of mammalian egg-sperm recognition
European Molecular Biology Organization
4 July 2010 - 4 July 2012
Snapshots of the beginning of life: molecular basis of mammalian egg-sperm interaction at fertilization
Swedish Research Council
1 January 2010 - 31 December 2012
EMBO Young Investigators Award 2009
Swedish Research Council
1 January 2010 - 31 December 2012
Characterization of epithelial stem cells marked by Lgr5 or Lgr6 expression and the role of Hedgehog signaling.
Swedish Research Council
1 January 2010 - 31 December 2012
Structural studies of zona pellucida domain proteins
Swedish Research Council
1 January 2008 - 31 December 2009
Structure determination of the zona pellucida domain by X-ray crystallography
Cordis
1 April 2006 - 31 March 2007
Structural studies of zona pellucida domain proteins
Swedish Research Council
1 January 2006 - 31 December 2007
Structural studies of mammalian fertilisation proteins
International Human Frontier Science Program Organization
1 May 2001 - 30 April 2004

Anställningar

Professor, Medicin, Huddinge, Karolinska Institutet, 2024-
Professor, Institutionen för biovetenskaper och näringslära, Karolinska Institutet, 2013-2024
Senior Forskare, Institutionen för biovetenskaper och näringslära, Karolinska Institutet, 2005-2013

Examina och utbildning

Ph.D, MRC Laboratory of Molecular Biology, University of Cambridge, 2000

Priser och utmärkelser

Knut och Alice Wallenbergs Stiftelse Stipendium, Knut and Alice Wallenberg Foundation, 2019
Center for Innovative Medicine Senior Investigator Grant, Karolinska Institutet, 2015
Hugo Theorell Prize for Biophysics, Svenska Föreningen för Biokemi, Biofysik och Molekylärbiologi, 2013
Göran Gustafsson Prize for Chemistry, Göran Gustafsson Foundation, 2012
Erik K. Fernström Prize, Fernströmstiftelsen, 2011
ERC Starting Grant, European Union, 2011
EMBO Young Investigator, European Molecular Biology Organization, 2010
Sven och Ebba-Christina Hagberg Prize for Medical Research, Sven and Ebba-Christina Hagberg Foundation, 2010
Human Frontier Science Program Long-Term Fellow, International Human Frontier Science Program Organization, 2001
EMBO Long-Term Fellow, European Molecular Biology Organization, 2001

Uppdrag i kommitté

Medlem, ClinGen HHT: Hereditary Hemorrhagic Telangiectasia Variant Curation Expert Panel, National Institutes of Health, https://www.clinicalgenome.org/affiliation/50037/, 2019-
Medlem, Nobelförsamlingen vid Karolinska Institutet, Karolinska Institutet, https://www.nobelprizemedicine.org/selecting-laureates/the-nobel-assembly, 2019-
Medlem, EMBO, European Molecular Biology Organization, https://people.embo.org/profile/luca-jovine, 2019-

Gästforskning och resestipendier

Postdoktor, Icahn School of Medicine at Mount Sinai, New York, 2000-2005

Om mig

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Artiklar

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Forskningsbidrag

Anställningar

Examina och utbildning

Priser och utmärkelser

Uppdrag i kommitté

Gästforskning och resestipendier

Nyheter från KI

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