Luca Jovine

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About me

I am a professor of structural biology and my research group studies the molecular basis of egg-sperm interaction at fertilization, a topic that is directly relevant to both understanding human infertility and identifying potential new methods of non-hormonal contraception. In parallel, we investigate a set of proteins that contain the same zona pellucida (ZP) module found in egg coat subunits but perform completely different biological functions. This part of our work has implications for the treatment of urinary tract infections - the most common type of non-epidemic bacterial infection in humans -, as well as kidney and vascular diseases.

More information on our research may be found on my research group's page (http://jovinelab.org).

Articles

Article: COMMUNICATIONS BIOLOGY. 2025;8(1):316
Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia
El Hamaoui D; Marchelli A; Gandrille S; Reboul E; Stepanian A; Palmier B; Jovine L; Lebrin F; Smadja DM; Bernabeu C; Denis CV; Gaussem P; Pasquali S; Kauskot A; Rossi E
Article: BLOOD. 2024;143(22):2314-2331
Mutations causing premature termination codons discriminate and generate cellular and clinical variability in HHT
Bernabeu-Herrero ME; Patel D; Bielowka A; Zhu J; Jain K; Mackay IS; Guerrero PC; Emanuelli G; Jovine L; Noseda M; Marciniak SJ; Aldred MA; Shovlin CL
Article: HUMAN MUTATION. 2024;2024:1-13
Specifications of the ACMG/AMP Variant Curation Guidelines for Hereditary Hemorrhagic Telangiectasia Genes-ENG and ACVRL1
DeMille D; McDonald J; Bernabeu C; Racher H; Olivieri C; Cantarini C; Sbalchiero A; Thompson BA; Jovine L; Shovlin CL; Dupuis-Girod S; Lesca G; Tusseau M; Ganguly A; Kasthuri RS; Jessen J; Massink MPG; Ichikawa S; Bayrak-Toydemir P
Journal article: ELIFE. 2024;13
Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse
Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
Journal article: ELIFE. 2024;13:RP93131
Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse.
Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
Journal article: JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE. 2024;8(s1):129
431 Defective uromodulin polymerization and peptide excretion in a natural canine model of kidney stones
Furrow E; Rampoldi L; Jovine L; Wesson JA; Treeful AE; Jayachandran M; Lieske JC; Romero MF; Lulich JP
Journal article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2023;34(11S):568
A Canine Model Implicates Uromodulin Peptides in Calcium Oxalate Urinary Stone Risk
Furrow E; Rampoldi L; Jovine L; Wesson J; Jayachandran M; Lieske JC; Romero MF; Lulich JP
Article: NATURE COMMUNICATIONS. 2023;14(1):3506
Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries
Gert KRB; Panser K; Surm J; Steinmetz BS; Schleiffer A; Jovine L; Moran Y; Kondrashov F; Pauli A
Article: PROTEIN SCIENCE. 2022;31(6):e4333
Complementing machine learning-based structure predictions with native mass spectrometry
Allison TM; Degiacomi MT; Marklund EG; Jovine L; Elofsson A; Benesch JLP; Landreh M
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:872740
A Non-Synonymous Point Mutation in a WD-40 Domain Repeat of EML5 Leads to Decreased Bovine Sperm Quality and Fertility
Nogueira E; Tirpak F; Hamilton LE; Zigo M; Kerns K; Sutovsky M; Kim J; Volkmann D; Jovine L; Taylor JF; Schnabel RD; Sutovsky P
Article: MOLECULAR REPRODUCTION AND DEVELOPMENT. 2021;88(10):686-693
Using machine learning to study protein-protein interactions: From the uromodulin polymer to egg zona pellucida filaments
Jovine L
Article: BLOOD. 2020;136(17):1907-1918
Mutational and phenotypic characterization of hereditary hemorrhagic telangiectasia
Shovlin CL; Simeoni I; Downes K; Frazer ZC; Megy K; Bernabeu-Herrero ME; Shurr A; Brimley J; Patel D; Kell L; Stephens J; Turbin IG; Aldred MA; Penkett CJ; Ouwehand WH; Jovine L; Turro E
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:572735
Molecular Mechanism Underlying the Action ofZona-pellucidaGlycoproteins on Mouse Sperm
Balbach M; Hamzeh H; Jikeli JF; Brenker C; Schiffer C; Hansen JN; Neugebauer P; Troetschel C; Jovine L; Han L; Florman HM; Kaupp UB; Struenker T; Wachten D
Article: SCIENTIFIC REPORTS. 2019;9(1):11601
Autosomal Dominant Tubulointerstitial Kidney Disease with Adult Onset due to a Novel Renin Mutation Mapping in the Mature Protein
Schaeffer C; Izzi C; Vettori A; Pasqualetto E; Cittaro D; Lazarevic D; Caridi G; Gnutti B; Mazza C; Jovine L; Scolari F; Rampoldi L
Article: GENE. 2019;696:33-39
Characterization of a mutation in the zona pellucida module of Endoglin that causes Hereditary Hemorrhagic Telangiectasia
Ruiz-Llorente L; Chiapparino E; Plumitallo S; Danesino C; Bayrak-Toydemir P; Pagella F; Manfredi G; Bernabeu C; Jovine L; Olivieri C
Article: IUCRJ. 2019;6(Pt 2):317-330
Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition
Cuppari A; Koerschgen H; Fahrenkamp D; Schmitz C; Guevara T; Karmilin K; Kuske M; Olf M; Dietzel E; Yiallouros I; de Sanctis D; Goulas T; Weiskirchen R; Jahnen-Dechent W; Floehr J; Stoecker W; Jovine L; Gomis-Rueth FX
Article: SCIENTIFIC REPORTS. 2016;6:32556
The C-terminal region of OVGP1 remodels the zona pellucida and modifies fertility parameters
Algarra B; Han L; Soriano-Ubeda C; Aviles M; Coy P; Jovine L; Jimenez-Movilla M
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2016;194(1):1-7
Easy mammalian expression and crystallography of maltose-binding protein-fused human proteins
Bokhove M; Al Hosseini HS; Saito T; Dioguardi E; Gegenschatz-Schmid K; Nishimura K; Raj I; de Sanctis D; Han L; Jovine L
Article: ELIFE. 2015;4:e08887
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin
Brunati M; Perucca S; Han L; Cattaneo A; Consolato F; Andolfo A; Schaeffer C; Olinger E; Peng J; Santambrogio S; Perrier R; Li S; Bokhove M; Bachi A; Hummler E; Devuyst O; Wu Q; Jovine L; Rampoldi L
Journal article: REPRODUCTION ABSTRACTS. 2014
Deletion of the C-terminal region of OVGP1 affects porcine IVF
Algarra B; Han L; Aviles M; Coy P; Jovine L; Jimenez-Movilla M
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2013;69(Pt 12):2563-2579
Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation
Cherry AL; Finta C; Karlstrom M; Jin Q; Schwend T; Astorga-Wells J; Zubarev RA; Del Campo M; Criswell AR; de Sanctis D; Jovine L; Toftgard R
Article: MOLECULAR BIOLOGY AND EVOLUTION. 2012;29(9):2147-2155
Evolution of the Voltage Sensor Domain of the Voltage-Sensitive Phosphoinositide Phosphatase VSP/TPTE Suggests a Role as a Proton Channel in Eutherian Mammals
Sutton KA; Jungnickel MK; Jovine L; Florman HM
Article: MOLECULAR BIOLOGY AND EVOLUTION. 2011;28(7):1963-1966
The Molecular Basis of Sex: Linking Yeast to Human
Swanson WJ; Aagaard JE; Vacquier VD; Monne M; Al Hosseini HS; Jovine L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;370(3):410-413
Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage
Santambrogio S; Cattaneo A; Bernascone I; Schwend T; Jovine L; Bachi A; Rampoldi L
Journal article: SOCIETY OF REPRODUCTION AND FERTILITY SUPPLEMENT. 2007;63:187-201
Features that affect secretion and assembly of zona pellucida glycoproteins during mammalian oogenesis.
Jovine L; Qi H; Williams Z; Litscher ES; Wassarman PM
Article: BMC BIOCHEMISTRY. 2006;7:11
The PLAC1-homology region of the ZP domain is sufficient for protein polymerisation.
Jovine L; Janssen WG; Litscher ES; Wassarman PM
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2006;207(1):30-39
Polypeptide encoded by mouse ZP3 exon-7 is necessary and sufficient for binding of mouse sperm in vitro
Williams Z; Litscher ES; Jovine L; Wassarman PM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(45):37585-37598
Mass spectrometric evidence that proteolytic processing of rainbow trout egg vitelline envelope proteins takes place on the egg
Darie CC; Biniossek ML; Gawinowicz MA; Milgrom Y; Thumfart JO; Jovine L; Litscher ES; Wassarman PM
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2005;234(1-2):95-103
Recent aspects of mammalian fertilization research
Wassarman PM; Jovine L; Qi HY; Williams Z; Darie C; Litscher ES
Article: BIOCHEMISTRY. 2004;43(23):7459-7478
Structural characterization of fish egg vitelline envelope proteins by mass spectrometry
Darie CC; Biniossek ML; Jovine L; Litscher ES; Wassarman PM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(16):5922-5927
A duplicated motif controls assembly of zona pellucida domain proteins
Jovine L; Qi HY; Williams Z; Litscher ES; Wassarman PM
Article: CYTOGENETIC AND GENOME RESEARCH. 2004;105(2-4):228-234
Mouse zona pellucida genes and glycoproteins
Wassarman PM; Jovine L; Litscher ES
Journal article: TRENDS IN BIOTECHNOLOGY. 2002;20(12):491-492
Macromolecular mimicry in protein synthesis: beware of imitations
Jovine L
Article: BMC CELL BIOLOGY. 2002;3:28
Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear
Jovine L; Park J; Wassarman PM
Article: MOLECULAR CELL. 2002;9(6):1251-1261
Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle
Oubridge C; Kuglstatter A; Jovine L; Nagai K
Article: NATURE CELL BIOLOGY. 2002;4(6):457-461
The ZP domain is a conserved module for polymerization of extracellular proteins
Jovine L; Qi HY; Williams Z; Litscher E; Wassarman PM
Journal article: TRENDS IN BIOTECHNOLOGY. 2002;20(5):190
Molecular beacons meet DNA–protein interactions: bye bye bandshift?
Jovine L
Journal article: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2001;12(7):286
Heavier weight on tubby
Jovine L
Journal article: TRENDS IN BIOTECHNOLOGY. 2001;19(8):284
Heavier weight on tubby
Jovine L
Article: JOURNAL OF MOLECULAR BIOLOGY. 2000;301(2):401-414
The crystal structure of yeast phenylalanine tRNA at 2.0 Å resolution: Cleavage by Mg²⁺ in 15-year old crystals
Jovine L; Djordjevic S; Rhodes D
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2000;56(Pt 8):1033-1037
Crystallization and preliminary X-ray analysis of the conserved domain IV of Escherichia coli 4.5S RNA
Jovine L; Hainz T; Oubridge C; Nagai K
Article: JOURNAL OF APPLIED CRYSTALLOGRAPHY. 2000;33(2):988-989
A simple technique to control macromolecular crystal nucleation efficiently using a standard vapour-diffusion setup
Jovine L
Article: STRUCTURE. 2000;8(5):527-540
Crystal structure of the Ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA
Jovine L; Hainzl T; Oubridge C; Scott WG; Li J; Sixma TK; Wonacott A; Skarzynski T; Nagai K
Article: FEBS LETTERS. 2000;468(1):59-64
The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region
Acquati F; Accarino M; Nucci C; Fumagalli P; Jovine L; Ottolenghi S; Taramelli R
Article: STRUCTURE. 1996;4(5):621-631
Two structurally different RNA molecules are bound by the spliceosomal protein U1A using the same recognition strategy
Jovine L; Oubridge C; Avis JM; Nagai K
Journal article: GENETICS. 1993;133(2):183-191
CONDITIONAL MUTATIONS IN THE YEAST DNA PRIMASE GENES AFFECT DIFFERENT ASPECTS OF DNA METABOLISM AND INTERACTIONS IN THE DNA-POLYMERASE ALPHA-PRIMASE COMPLEX
LONGHESE MP; JOVINE L; PLEVANI P; LUCCHINI G
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Employments

Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2024-
Professor, Department of Biosciences and Nutrition, Karolinska Institutet, 2013-2024
Assistant Professor, Department of Biosciences and Nutrition, Karolinska Institutet, 2005-2013

Degrees and Education

Ph.D, MRC Laboratory of Molecular Biology, University of Cambridge, 2000

Distinction and awards

Knut and Alice Wallenberg Foundation Project Grant, Knut and Alice Wallenberg Foundation, 2019
Center for Innovative Medicine Senior Investigator Grant, Karolinska Institutet, 2015
Hugo Theorell Prize for Biophysics, Svenska Föreningen för Biokemi, Biofysik och Molekylärbiologi, 2013
Göran Gustafsson Prize for Chemistry, Göran Gustafsson Foundation, 2012
Erik K. Fernström Prize, Fernströmstiftelsen, 2011
ERC Starting Grant, European Union, 2011
EMBO Young Investigator, European Molecular Biology Organization, 2010
Sven och Ebba-Christina Hagberg Prize for Medical Research, Sven and Ebba-Christina Hagberg Foundation, 2010
Human Frontier Science Program Long-Term Fellow, International Human Frontier Science Program Organization, 2001
EMBO Long-Term Fellow, European Molecular Biology Organization, 2001

Committee work

Member, ClinGen HHT: Hereditary Hemorrhagic Telangiectasia Variant Curation Expert Panel, National Institutes of Health, https://www.clinicalgenome.org/affiliation/50037/, 2019-
Member, The Nobel Assembly at Karolinska Institutet, Karolinska Institutet, https://www.nobelprizemedicine.org/selecting-laureates/the-nobel-assembly, 2019-
Member, EMBO, European Molecular Biology Organization, https://people.embo.org/profile/luca-jovine, 2019-

Visiting research fellowships

Postdoctoral fellow, Icahn School of Medicine at Mount Sinai, New York, 2000-2005

About me

Articles

Employments

Degrees and Education

Distinction and awards

Committee work

Visiting research fellowships

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