Lena Ekström

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Adjungerad professor i farmakologi med inriktning mot dopingforskning vid
institutionen för laboratoriemedicin från 1 juni 2022.
Primär anställning: Sjukhuskemist vid Karolinska universitetssjukhuset.

Forskningsbeskrivning

Lena Ekström forskar om hur dopingtester kan förbättras. Hennes ordinarie
arbete är vid Karolinska universitetssjukhusets enhet för klinisk
farmakologi, där Svenska Dopinglaboratoriet ligger. I sin forskning
fokuserar hon på testosteron, andra anabola steroider och tillväxthormon
samt erytropoetin, EPO/./
I kliniska studier av friska försökspersoner som får ta dopingklassade
läkemedel studerar Lena Ekström hur indikatorer för dopingsubstanserna
varierar i urin- eller blodprov över tid och mellan individer.
Könsskillnader samt variation hos kvinnor under menscykeln är också
viktiga aspekter.
Som postdoc upptäckte Lena Ekström att en vanlig genetisk variation –
avsaknad av enzymet UGT2B17 – gör att idrottare kan dopa sig med
testosteron utan att överträda de generella gränsvärden som då gällde.
Upptäckten bidrog till införandet i internationell elitidrott av
individualiserade gränsvärden baserade på långa mätserier.

Artiklar

Journal article: EXPERIMENTAL PHYSIOLOGY. 2026;111(7):3437-3438
Reply to letter to the editor in response to: "Carbon monoxide to 'simulate altitude'"
Villanova S; Porcelli S; Ekstrom L; Cardinale DA
Article: EXPERIMENTAL PHYSIOLOGY. 2026;111(4):1891-1903
Effect of live-high, train-low strategy induced by chronic low-dose carbon monoxide exposure on haematological parameters and performance in trained individuals
Villanova S; Porcelli S; Ekstrom L; Cardinale DA
Article: FRONTIERS IN PHYSIOLOGY. 2026;17:1733515
Variation of the steroid profile in relation to training in women and its importance for anti-doping testing
Andersson A; Ekstrom L; Salamin O; Nicoli R; Hirschberg AL; Eklund E
Article: DRUG TESTING AND ANALYSIS. 2026;18(3):405-413
Lomerizine M6-An Important Urinary Metabolite in Anti-Doping Control Analysis for Correct Detection of Trimetazidine Abuse in Both Females and Males
Bohlin KP; Ekstrom L; Pohanka A; Lehtihet M; Ericsson M
Article: DRUG TESTING AND ANALYSIS. 2025;17(12):2374-2383
Detection of Anabolic Androgenic Steroids and Steroid Esters-Comparing Dried Blood Spots Collection Devices and Urine Samples
Suominen T; von Walden J; Harju L; Pohanka A; Schulze J; Lehtihet M; Ekstrom L
Article: DRUG TESTING AND ANALYSIS. 2025;17(12):2421-2428
Prevalence of AAS-Positive Samples at Drug Abuse Laboratory Sweden Between 2014 and 2023 and Sub-Study of Dual Use of AAS and Narcotics
Bohlin KP; Villen T; Hopcraft O; Pohanka A; Ekstrom L
Article: DRUG TESTING AND ANALYSIS. 2025;17(11):2159-2163
Avoid Falsely Accusing Female Athletes Who Use Levonorgestrel of Doping
Andersson A; Pohanka A; Lehtihet M; Ekstrom L
Article: DRUG TESTING AND ANALYSIS. 2025;17(11):2220-2227
Detection of a Single Microdose of Testosterone and Recombinant EPO in Healthy Volunteers
Heiland C; Hopcraft O; Johanson M; Pohanka A; Lehtihet M; Ekstrom L
Article: EPILEPSY RESEARCH. 2025;213:107554
UGT polymorphisms and epileptic seizure control in pregnant women treated with Lamotrigine
Hansen NS; Ohman I; Ekstrom L; Petrenaite V
Article: INTERNATIONAL JOURNAL OF QUALITATIVE STUDIES ON HEALTH AND WELL-BEING. 2024;19(1):2292826
Lived experiences of closeness to a person using Anabolic androgenic steroids a next of kin perspective
Borjesson A; Ekebergh M; Dahl M-L; Ekstrom L; Lehtihet M; Vicente V
Article: DRUG TESTING AND ANALYSIS. 2024;16(11):1319-1322
Evaluation of a single Eporatio® micro-dose in urine and dried blood spots
Heiland CE; Lehtihet M; Borjesson A; Ekstroem L
Article: DRUG TESTING AND ANALYSIS. 2024;16(8):827-834
Detection of anabolic agents including selective androgen receptor modulators in samples outside of sport
Bohlin KP; Pohanka A; Andersson A; Villen T; Ekstrom L
Article: DRUG TESTING AND ANALYSIS. 2023;15(7):769-778
Intra-individual stability of longitudinal urinary steroid profiles in Swedish athletes
Ekstrom L; Mous D; Heiland V; Heiland EG; Schulze J
Article: DRUG TESTING AND ANALYSIS. 2023;15(6):678-688
Detection of anabolic androgenic steroids in serum samples
Makvandi B; Pohanka A; Bergstrom M; Borjesson A; Lehtihet M; Ekstrom L; Zheng Y
Article: DRUG TESTING AND ANALYSIS. 2023;15(6):599-604
Supra-physiological doses of anabolic androgenic steroids impact erythropoietin and blood parameters
Heiland CE; Schickel Y; Lehtihet M; Borjesson A; Ekstrom L
Article: DRUG TESTING AND ANALYSIS. 2023;15(4):465-469
Usefulness of serum androgen isotope ratio mass spectrometry (IRMS) to detect testosterone supplementation in women
Andersson A; Piper T; Ekstrom L; Hirschberg AL; Thevis M
Article: DRUG TESTING AND ANALYSIS. 2023;15(1):134-138
Disposition of serum steroids in response to combined oral contraceptives and menstrual cycle phases: A double-blind, randomized, placebo-controlled study
Knutsson JE; Ekstrom L; Hirschberg AL
Article: DRUG TESTING AND ANALYSIS. 2022;14(8):1377-1386
Optimizing detection of erythropoietin receptor agonists from dried blood spots for anti-doping application
Heiland CE; Ericsson M; Pohanka A; Ekstrom L; Marchand A
Article: FRONTIERS IN PHYSIOLOGY. 2022;13:844133
Klotho Polymorphism in Association With Serum Testosterone and Knee Strength in Women After Testosterone Administration
Ekstroem L; Knutsson JE; Stephanou C; Hirschberg AL
Article: EPILEPSY RESEARCH. 2022;182:106897
Effect of UGT1A4, UGT2B7, UGT2B15, UGT2B17 and ABC1B polymorphisms on lamotrigine metabolism in Danish patients
Petrenaite V; Ohman I; Jantzen FPT; Ekstrom L
Visa fler

Alla övriga publikationer

Preprint: BIORXIV. 2021
MiRNA and Erythropoietin profiles during the menstrual cycle in relation to hematological and lipid biomarkers
Bergström H; Heiland C; Björkhem-Bergman L; Ekström L
Conference publication: EPILEPSIA. 2018;59:S214
Effect Of UGT1A4 And 2B7 Polymorphisms On Lamotrigine Glucuronidation In Epilepsy Patients
Petrenaite V; Ohman I; Ekstrom L; Bertilsson L; Jantzen FT; Saebye D; Tomson T; Sabers A
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:63
TESTOSTERONE REDUCES CIRCULATING PCSK9 BUT DOES NOT INFLUENCE CHOLESTEROL OR BILE ACID SYNTHESIS IN HEALTHY MALES
Laskar MG; Beckman L; Laskar A; Garevik N; Ekstrom L; Rudling M; Angelin B
Conference publication: EPILEPSIA. 2016;57:68
EFFECT OF UGT1A4 AND UGT2B7 POLYMORPHISM ON LAMOTRIGINE METABOLISM DURING PREGNANCY
Petrenaite V; Ohman I; Ekstrom L; Bertilsson L; Saebye D; Tomson T; Sabers A
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2016;23:504
Effect of UGT1A4 and UGT2B7 polymorphism on lamotrigine metabolism during pregnancy
Petrenaite V; Ohman I; Ekstrom L; Bertilsson L; Saebye D; Tomson T; Sabers A
Conference publication: GYNECOLOGICAL ENDOCRINOLOGY. 2016;32:48
Digit ratio (2D: 4D ratio) in female Olympic athletes in relation to urinary steroid profile
Lindgren E; Mullen J; Ekstrom L; Hirschberg A
Published conference paper: DRUG TESTING AND ANALYSIS. 2015;7(11-12):1063-1070
Dose-dependent testosterone sensitivity of the steroidal passport and GC-C-IRMS analysis in relation to the UGT2B17 deletion polymorphism
Strahm E; Mullen JE; Garevik N; Ericsson M; Schulze JJ; Rane A; Ekstrom L
Editorial: FRONTIERS IN ENDOCRINOLOGY. 2015;6:50
Editorial: Variation in phase II metabolism of sex steroids - causes and consequences
Schulze JJ; Ekstrom L
Review: LAKARTIDNINGEN. 2012;109(29-31):1347-1349
[Introduction of genetic analysis can provide us with safer doping tests. Large variation in androgen turnover creates problems in current tests].
Rane A; Ekström L
Review: IN VIVO. 2012;26(4):527-535
Exploring Anticarcinogenic Agents in a Rat Hepatocarcinogenesis Model - Focus on Selenium and Statins
Bjorkhem-Bergman L; Ekstrom L; Eriksson LC
Conference publication: LUMINESCENCE. 2012;27(2):141
Whole-cell bioluminescent biosensors for on-site antidoping screening
Michelini E; Cevenini L; Canali C; Ekstroem L; Schulze J; Garle M; Rane A; Roda A
Conference publication: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2009;105:44
THE PLEIOTROPIC EFFECTS OF FLUVASTATIN IN HUMAN VASCULAR ENDOTHELIUM
Skogastierna C; Luksha L; Kublickiene K; Eliasson E; Rane A; Ekstrom L
Review: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. 2009;5(7):731-744
Genetic variation in androgen disposition: implications in clinical medicine including testosterone abuse
Schulze JJ; Rane A; Ekstrom L
Conference publication: ACTA PHARMACOLOGICA SINICA. 2006;27:231
Large differences in testosterone excretion in Asian and Caucasian men associated with an UGT2B17 polymorphism-implications for doping tests
Rane A; Jakobsson J; Ekström L; Inotsume N; Garle M; Lorentzon M; Ohlsson C; Roh HK; Carlström K
Book chapter: OXIDATIVE STRESS, DISEASE AND CANCER. 2006;p. 371-460
Oxidative Stress, Genetic Variation, and Disease
Lyrenäs L; Zotova E; Ekström L; Morgenstern R
Review: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2001;389(1):84-93
Oxidative stress, human genetic variation, and disease
Forsberg L; de Faire U; Morgenstern R
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):301-303
Structure and transcriptional regulation of the human microsomal glutathione transferase 1 (MGST1) and prostaglandin E synthase (PGES) genes
Forsberg L; Persson L; Kelner MJ; Jakobsson PJ; Morgenstern R

Anställningar

Anknuten till Undervisning/Handledning, Laboratoriemedicin, Karolinska Institutet, 2026-2026
Adjungerad Professor, Laboratoriemedicin, Karolinska Institutet, 2022-2026

Examina och utbildning

Docent, Molekylär genetik, Karolinska Institutet, 2006
MEDICINE DOKTORSEXAMEN, Institutet för miljömedicin, Karolinska Institutet, 2000

Om mig

Forskningsbeskrivning

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI