Lena Ekström

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Adjungerad professor i farmakologi med inriktning mot dopingforskning vid
institutionen för laboratoriemedicin från 1 juni 2022.
Primär anställning: Sjukhuskemist vid Karolinska universitetssjukhuset.

Forskningsbeskrivning

Lena Ekström forskar om hur dopingtester kan förbättras. Hennes ordinarie
arbete är vid Karolinska universitetssjukhusets enhet för klinisk
farmakologi, där Svenska Dopinglaboratoriet ligger. I sin forskning
fokuserar hon på testosteron, andra anabola steroider och tillväxthormon
samt erytropoetin, EPO/./
I kliniska studier av friska försökspersoner som får ta dopingklassade
läkemedel studerar Lena Ekström hur indikatorer för dopingsubstanserna
varierar i urin- eller blodprov över tid och mellan individer.
Könsskillnader samt variation hos kvinnor under menscykeln är också
viktiga aspekter.
Som postdoc upptäckte Lena Ekström att en vanlig genetisk variation –
avsaknad av enzymet UGT2B17 – gör att idrottare kan dopa sig med
testosteron utan att överträda de generella gränsvärden som då gällde.
Upptäckten bidrog till införandet i internationell elitidrott av
individualiserade gränsvärden baserade på långa mätserier.

Artiklar

Article: INTERNATIONAL JOURNAL OF QUALITATIVE STUDIES ON HEALTH & WELL-BEING. 2024;19(1):2292826
Lived experiences of closeness to a person using Anabolic androgenic steroids a next of kin perspective
Borjesson A; Ekebergh M; Dahl M-L; Ekstrom L; Lehtihet M; Vicente V
Article: DRUG TESTING AND ANALYSIS. 2024;16(11):1319-1322
Evaluation of a single Eporatio® micro-dose in urine and dried blood spots
Heiland CE; Lehtihet M; Borjesson A; Ekstroem L
Article: DRUG TESTING AND ANALYSIS. 2024;16(8):827-834
Detection of anabolic agents including selective androgen receptor modulators in samples outside of sport
Bohlin KP; Pohanka A; Andersson A; Villen T; Ekstrom L
Article: DRUG TESTING AND ANALYSIS. 2023;15(7):769-778
Intra-individual stability of longitudinal urinary steroid profiles in Swedish athletes
Ekstrom L; Mous D; Heiland V; Heiland EG; Schulze J
Article: DRUG TESTING AND ANALYSIS. 2023;15(6):678-688
Detection of anabolic androgenic steroids in serum samples
Makvandi B; Pohanka A; Bergstrom M; Borjesson A; Lehtihet M; Ekstrom L; Zheng Y
Article: DRUG TESTING AND ANALYSIS. 2023;15(6):599-604
Supra-physiological doses of anabolic androgenic steroids impact erythropoietin and blood parameters
Heiland CE; Schickel Y; Lehtihet M; Borjesson A; Ekstrom L
Article: DRUG TESTING AND ANALYSIS. 2023;15(4):465-469
Usefulness of serum androgen isotope ratio mass spectrometry (IRMS) to detect testosterone supplementation in women
Andersson A; Piper T; Ekstrom L; Hirschberg AL; Thevis M
Article: DRUG TESTING AND ANALYSIS. 2023;15(1):134-138
Disposition of serum steroids in response to combined oral contraceptives and menstrual cycle phases: A double-blind, randomized, placebo-controlled study
Knutsson JE; Ekstrom L; Hirschberg AL
Article: DRUG TESTING AND ANALYSIS. 2022;14(8):1377-1386
Optimizing detection of erythropoietin receptor agonists from dried blood spots for anti-doping application
Heiland CE; Ericsson M; Pohanka A; Ekstrom L; Marchand A
Article: EPILEPSY RESEARCH. 2022;182:106897
Effect of UGT1A4, UGT2B7, UGT2B15, UGT2B17 and ABC1B polymorphisms on lamotrigine metabolism in Danish patients
Petrenaite V; Ohman I; Jantzen FPT; Ekstrom L
Article: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2022;130(4):492-500
Plasma concentrations of methylphenidate enantiomers in adults with ADHD and substance use disorder, with focus on high doses and relationship to carboxylesterase activity
Arvidsson M; Franck J; Ackehed G; Bergstrand MP; Ekstrom L; Rosenborg S; Dahl M-L
Article: FRONTIERS IN PHYSIOLOGY. 2022;13:844133
Klotho Polymorphism in Association With Serum Testosterone and Knee Strength in Women After Testosterone Administration
Ekstroem L; Knutsson JE; Stephanou C; Hirschberg AL
Article: FRONTIERS IN SPORTS AND ACTIVE LIVING. 2022;4:829940
Studies of IGF-I and Klotho Protein in Relation to Anabolic-Androgenic Steroid and Growth Hormone Administrations
Lehtihet M; Stephanou C; Borjesson A; Bhuiyan H; Pohanka A; Ekstrom L
Article: PHARMACOLOGY RESEARCH & PERSPECTIVES. 2021;9(6):e00884
Studies on CYP3A activity during the menstrual cycle as measured by urinary 6β-hydroxycortisol/cortisol
Bergstrom H; Lindahl A; Warnqvist A; Diczfalusy U; Ekstrom L; Bjorkhem-Bergman L
Article: DRUG TESTING AND ANALYSIS. 2021;13(8):1576-1579
Re-evaluation of combined ((ES/EG)/(TS/TG)) ratio as a marker of testosterone intake in men
Schulze J; Pettersson-Bohlin K; Thorngren J-O; Ekstrom L
Article: BMC WOMEN'S HEALTH. 2021;21(1):166
Variations in biomarkers of dyslipidemia and dysbiosis during the menstrual cycle: a pilot study in healthy volunteers
Bergstrom H; Ekstrom L; Warnqvist A; Bergman P; Bjorkhem-Bergman L
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2021;106(3):697-707
Disposition of Urinary and Serum Steroid Metabolites in Response to Testosterone Administration in Healthy Women
Knutsson JE; Andersson A; Baekken LV; Pohanka A; Ekstrom L; Hirschberg AL
Article: DRUG TESTING AND ANALYSIS. 2021;13(3):550-557
Urinary steroid profile in relation to the menstrual cycle
Schulze J; Suominen T; Bergstrom H; Ericsson M; Bjorkhem Bergman L; Ekstrom L
Article: FRONTIERS IN REPRODUCTIVE HEALTH. 2021;3:787954
A Summary of Online Enquiries Submitted to Anti-doping Hotline 2005-2018
Ekstrom L; Brostrom S; Dahl M-L; Borjesson A
Article: FRONTIERS IN SPORTS AND ACTIVE LIVING. 2021;3:656413
Women's Experiences of Using Anabolic Androgenic Steroids
Boerjesson A; Ekebergh M; Dahl M-L; Ekstroem L; Lehtihet M; Vicente V
Article: FRONTIERS IN PHYSIOLOGY. 2021;12:702305
Urinary Steroid Profile in Elite Female Athletes in Relation to Serum Androgens and in Comparison With Untrained Controls
Eklund E; Andersson A; Ekstroem L; Hirschberg AL
Article: INTERNATIONAL JOURNAL OF QUALITATIVE STUDIES ON HEALTH & WELL-BEING. 2021;16(1):1927490
Men′s experiences of using anabolic androgenic steroids
Borjesson A; Ekebergh M; Dahl M-L; Ekstrom L; Lehtihet M; Vicente V
Article: DRUG TESTING AND ANALYSIS. 2020;12(11-12):1620-1628
The intra-individual stability of GH biomarkers IGF-I and P-III-NP in relation to GHRH administration, menstrual cycle, and hematological parameters
Ericsson M; Bhuiyan H; Yousif B; Lehtihet M; Ekstrom L
Article: DRUG TESTING AND ANALYSIS. 2020;12(9):1229-1240
Fluctuations in hematological athlete biological passport biomarkers in relation to the menstrual cycle
Mullen J; Baekken L; Bergstrom H; Bjorkhem Bergman L; Ericsson M; Ekstrom L
Article: DRUG TESTING AND ANALYSIS. 2020;12(6):720-730
Inter-individual variation of the urinary steroid profiles in Swedish and Norwegian athletes
Mullen J; Baekken LV; Tormakangas T; Ekstrom L; Ericsson M; Hullstein IR; Schulze JJ
Article: DRUG TESTING AND ANALYSIS. 2020;12(6):711-719
Longitudinal studies of putative growth hormone (GH) biomarkers and hematological and steroidal parameters in relation to 2 weeks administration of human recombinant GH
Sieckmann T; Elmongy H; Ericsson M; Bhuiyan H; Lehtihet M; Ekstrom L
Article: MEDICINA. 2020;56(6):E265-265
Male Anabolic Androgenic Steroid Users with Personality Disorders Report More Aggressive Feelings, Suicidal Thoughts, and Criminality
Borjesson A; Moller C; Hagelin A; Vicente V; Rane A; Lehtihet M; Dahl M-L; Garevik N; Ekstrom L
Article: DRUG TESTING AND ANALYSIS. 2020;12(4):514-523
Studies of athlete biological passport biomarkers and clinical parameters in male and female users of anabolic androgenic steroids and other doping agents
Borjesson A; Lehtihet M; Andersson A; Dahl M-L; Vicente V; Ericsson M; Ekstrom L
Article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:292
Digit Ratio (2D:4D) and Physical Performance in Female Olympic Athletes
Eklund E; Ekstrom L; Thorngren J-O; Ericsson M; Berglund B; Hirschberg AL
Article: DRUG TESTING AND ANALYSIS. 2019;11(9):1284-1289
Impact of hormonal contraceptives on urinary steroid profile in relation to serum hormone changes and CYP17A1 polymorphism
Ekstrom L; Knutsson JE; Mullen J; Ericsson M; Hirscberg AL
Article: ENDOCRINE CONNECTIONS. 2019;8(7):1070-1081
Impact of vitamin D and vitamin D receptor TaqI polymorphism in primary human myoblasts
Saini A; Bjorkhem-Bergman L; Bostrom J; Lilja M; Melin M; Olsson K; Ekstrom L; Bergman P; Altun M; Rullman E; Gustafsson T
Article: DRUG TESTING AND ANALYSIS. 2019;11(3):411-421
Longitudinally monitoring of P-III-NP, IGF-I, and GH-2000 score increases the probability of detecting two weeks' administration of low-dose recombinant growth hormone compared to GH-2000 decision limit and GH isoform test and micro RNA markers
Lehtihet M; Bhuiyan H; Dalby A; Ericsson M; Ekstrom L
Article: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES. 2018;37(9):1735-1744
Vitamin D supplementation to persistent carriers of MRSA-a randomized and placebo-controlled clinical trial
Bjorkhem-Bergman L; Missailidis C; Karlsson-Valik J; Tammelin A; Ekstrom L; Bottai M; Hammar U; Lindh G; Bergman P
Article: BMC RESEARCH NOTES. 2018;11(1):619
Vitamin D binding protein is not affected by high-dose vitamin D supplementation: a post hoc analysis of a randomised, placebo-controlled study.
Björkhem-Bergman L; Torefalk E; Ekström L; Bergman P
Article: JOURNAL OF THE ENDOCRINE SOCIETY. 2018;2(7):597-608
Pregnancy-Induced Perturbation of Urinary Androgenic Steroid Disposition
Gadot Y; Thorngren J-O; Eklund E; Ekstrom L; Rane A
Article: DRUG TESTING AND ANALYSIS. 2018;10(5):839-848
Sensitivity of doping biomarkers after administration of a single dose testosterone gel
Mullen J; Borjesson A; Hopcraft O; Schulze JJ; Ericsson M; Rane A; Lehtihet M; Ekstrom L
Article: DRUG TESTING AND ANALYSIS. 2018;10(4):723-730
Codeine influences the serum and urinary profile of endogenous androgens but does not interact with the excretion rate of administered testosterone
Lehtihet M; Andersson A; Borjesson A; Schulze J; Rane A; Ericsson M; Ekstrom L
Article: EPILEPSY RESEARCH. 2018;140:199-208
UGT polymorphisms and lamotrigine clearance during pregnancy
Petrenaite V; Ohman I; Ekstrom L; Saebye D; Hansen TF; Tomson T; Sabers A
Article: BMC RESEARCH NOTES. 2018;11(1):51
Vitamin D receptor rs2228570 polymorphism is associated with LH levels in men exposed to anabolic androgenic steroids.
Björkhem-Bergman L; Lehtihet M; Rane A; Ekström L
Article: DRUG TESTING AND ANALYSIS. 2018;10(7):1070-1075
Pregnancy greatly affects the steroidal module of the Athlete Biological Passport
Mullen J; Gadot Y; Eklund E; Andersson A; J. Schulze J; Ericsson M; Hirschberg AL; Rane A; Ekstrom L
Article: BRITISH JOURNAL OF SPORTS MEDICINE. 2017;51(17):1301-1308
Serum androgen profile and physical performance in women Olympic athletes
Eklund E; Berglund B; Labrie F; Carlstrom K; Ekstrom L; Hirschberg AL
Article: DRUG TESTING AND ANALYSIS. 2017;9(7):994-1000
Discordant genotyping results using DNA isolated from anti-doping control urine samples
Choong E; Schulze JJ; Ericsson M; Rane A; Ekstrom L
Article: DRUG TESTING AND ANALYSIS. 2017;9(7):1034-1042
Urinary steroid profile in females - the impact of menstrual cycle and emergency contraceptives
Mullen JE; Thorngren J-O; Schulze JJ; Ericsson M; Garevik N; Lehtihet M; Ekstrom L
Article: HORMONE AND METABOLIC RESEARCH. 2016;48(12):834-839
Genetic Expression Profile of Vitamin D Metabolizing Enzymes in the First Trimester
Ekstrom L; Storbjork L; Bjorkhem-Bergman L
Article: ANDROLOGIA. 2016;48(5):595-600
Impact of single-dose nandrolone decanoate on gonadotropins, blood lipids and HMG CoA reductase in healthy men
Garevik N; Borjesson A; Choong E; Ekstrom L; Lehtihet M
Article: STEROIDS. 2016;108:105-111
Atypical excretion profile and GC/C/IRMS findings may last for nine months after a single dose of nandrolone decanoate
Palonek E; Ericsson M; Garevik N; Rane A; Lehtihet M; Ekstrom L
Article: SUBSTANCE ABUSE: TREATMENT, PREVENTION, AND POLICY. 2016;11:11
Recruitment to doping and help-seeking behavior of eight female AAS users
Borjesson A; Garevik N; Dahl M-L; Rane A; Ekstrom L
Article: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2016;118(3):214-218
Low Vitamin D Levels and Genetic Polymorphism in the Vitamin D Receptor are Associated with Increased Risk of Statin-Induced Myopathy
Ovesjo M-L; Skilving I; Bergman P; Rane A; Ekstrom L; Bjorkhem-Bergman L
Article: PHARMACOLOGY RESEARCH & PERSPECTIVES. 2015;3(6):e00192
miRNA-27b levels are associated with CYP3A activity in vitro and in vivo.
Ekström L; Skilving I; Ovesjö M-L; Aklillu E; Nylén H; Rane A; Diczfalusy U; Björkhem-Bergman L
Article: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2015;117(4):261-266
Expression of CYP3A4 and CYP3A7 in Human Foetal Tissues and its Correlation with Nuclear Receptors
Betts S; Bjorkhem-Bergman L; Rane A; Ekstrom L
Article: PHARMACOGENOMICS JOURNAL. 2015;15(4):293-297
Genetic variation, expression and ontogeny of sulfotransferase SULT2A1 in humans
Ekstrom L; Rane A
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;82(1):55-62
Vitamin D status in Well-Controlled Caucasian HIV Patients in Relation to Inflammatory and Metabolic Markers - A Cross-Sectional Cohort Study in Sweden
Missailidis C; Hoijer J; Johansson M; Ekstrom L; Bratt G; Hejdeman B; Bergman P
Article: PHARMACOLOGY RESEARCH & PERSPECTIVES. 2014;2(6):e00071
Detection of morphine-3-sulfate and morphine-6-sulfate in human urine and plasma, and formation in liver cytosol.
Andersson M; Björkhem-Bergman L; Ekström L; Bergqvist L; Lagercrantz H; Rane A; Beck O
Article: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2014;115(4):366-371
Plasma Levels of 25-Hydroxyvitamin D₃ and In Vivo Markers of Cytochrome P450 3A Activity in Swedes and Koreans: Effects of a Genetic Polymorphism and Oral Contraceptives
Nylen H; Bjorkhem-Bergman L; Ekstrom L; Roh H-K; Bertilsson L; Eliasson E; Lindh JD; Diczfalusy U
Journal article: JOURNAL OF HORMONES. 2014;2014(1):1-7
Perturbation of the Hematopoietic Profile by Anabolic Androgenic Steroids
Mullen JE; Gårevik N; Schulze JJ; Rane A; Bergman LB; Ekström L
Article: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (EJPC). 2014;21(8):1049-1054
A supraphysiological dose of testosterone induces nitric oxide production and oxidative stress
Skogastierna C; Hotzen M; Rane A; Ekstrom L
Article: SUBSTANCE ABUSE AND REHABILITATION. 2014;5:121-127
Effects of different doses of testosterone on gonadotropins, 25-hydroxyvitamin D3, and blood lipids in healthy men.
Gårevik N; Rane A; Björkhem-Bergman L; Ekström L
Article: FRONTIERS IN ENDOCRINOLOGY. 2014;5:50
The impact of genetics and hormonal contraceptives on the steroid profile in female athletes
Schulze JJ; Mullen JE; Lindgren EB; Ericsson M; Ekstrom L; Hirschberg AL
Article: FRONTIERS IN GENETICS. 2014;5:58
CYP2C8 and CYP2C9 mRNA expression profile in the human fetus
Johansson M; Strahm E; Rane A; Ekstrom L
Article: FEBS OPEN BIO. 2014;4:886-891
Prenatal expression of thioredoxin reductase 1 (TRXR1) and microsomal glutathione transferase 1 (MGST1) in humans
Bjorkhem-Bergman L; Johansson M; Morgenstern R; Rane A; Ekstrom L
Article: FRONTIERS IN PHARMACOLOGY. 2014;5:132
PDE7B is involved in nandrolone decanoate hydrolysis in liver cytosol and its transcription is up-regulated by androgens in HepG2
Strahm E; Rane A; Ekstrom L
Article: PHARMACOGENETICS AND GENOMICS. 2013;23(12):684-696
Expression of UGT2B7 is driven by two mutually exclusive promoters and alternative splicing in human tissues: changes from prenatal life to adulthood and in kidney cancer
Menard V; Levesque E; Chen S; Eap O; Joy MS; Ekstrom L; Rane A; Guillemette C
Article: DRUG METABOLISM AND DISPOSITION. 2013;41(9):1610-1615
Atorvastatin Treatment Induces Uptake and Efflux Transporters in Human Liver
Bjorkhem-Bergman L; Bergstrom H; Johansson M; Parini P; Eriksson M; Rane A; Ekstrom L
Article: DRUG METABOLISM AND DISPOSITION. 2013;41(4):704-708
Serum Levels of 25-Hydroxyvitamin D and the CYP3A Biomarker 4β-Hydroxycholesterol in a High-Dose Vitamin D Supplementation Study
Bjorkhem-Bergman L; Nylen H; Norlin A-C; Lindh JD; Ekstrom L; Eliasson E; Bergman P; Diczfalusy U
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2013;43(3):248-255
Testosterone challenge and androgen receptor activity in relation to UGT2B17 genotypes
Ekstrom L; Cevenini L; Michelini E; Schulze J; Thorngren J-O; Belanger A; Guillemette C; Garle M; Roda A; Rane A
Article: DRUG METABOLISM AND DISPOSITION. 2013;41(2):291-295
Tissue Distribution and Relative Gene Expression of UDP-Glucuronosyltransferases (2B7, 2B15, 2B17) in the Human Fetus
Ekstrom L; Johansson M; Rane A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;430(1):90-94
Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells
Ekstrom L; Johansson M; Monostory K; Rundlof A-K; Arner ESJ; Bjorkhem-Bergman L
Article: FRONTIERS IN ENDOCRINOLOGY. 2013;4:88
SULT2A1 Gene Copy Number Variation is Associated with Urinary Excretion Rate of Steroid Sulfates.
Schulze J; Johansson M; Thörngren J-O; Garle M; Rane A; Ekström L
Article: FRONTIERS IN ENDOCRINOLOGY. 2013;4:75
Implication of Human UGT2B7, 2B15, and 2B17 in 19-Norandrosterone Metabolism.
Strahm E; Sjöberg U; Garle M; Rane A; Ekström L
Article: FRONTIERS IN ENDOCRINOLOGY. 2013;4:51
Non-steroidal anti-inflammatory drugs do not influence the urinary testosterone/epitestosterone glucuronide ratio.
Lundmark J; Gårevik N; Thörngren J-O; Garle M; Ekström L; Rane A; Schulze JJ
Article: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 2013;61(1):1-7
Influence of Simvastatin on the Thromboxane and Prostacyclin Pathways, In Vitro and In Vivo
Skogastierna C; Bjorkhem-Bergman L; Bergman P; Eliasson E; Rane A; Ekstrom L
Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2012;74(1):3-15
Androgens and doping tests: genetic variation and pit-falls
Rane A; Ekstrom L
Article: SUBSTANCE ABUSE: TREATMENT, PREVENTION, AND POLICY. 2012;7:12
Single dose testosterone increases total cholesterol levels and induces the expression of HMG CoA Reductase
Garevik N; Skogastierna C; Rane A; Ekstrom L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2012;417(3):1046-1051
Statins inhibit expression of Thioredoxin reductase 1 in rat and human liver and reduce tumour development
Skogastierna C; Johansson M; Parini P; Eriksson M; Eriksson LC; Ekstrom L; Bjorkhem-Bergman L
Article: BMJ OPEN. 2012;2(6):e001663
Vitamin D₃ supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study
Bergman P; Norlin A-C; Hansen S; Rekha RS; Agerberth B; Bjorkhem-Bergman L; Ekstrom L; Lindh JD; Andersson J
Article: FRONTIERS IN PHARMACOLOGY. 2012;3:151
Basal and regulatory promoter studies of the AKR1C3 gene in relation to prostate cancer
Schulze JJ; Karypidis H; Ekstrom L
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2011;127(3-5):295-300
Long term perturbation of endocrine parameters and cholesterol metabolism after discontinued abuse of anabolic androgenic steroids
Garevik N; Strahm E; Garle M; Lundmark J; Stahle L; Ekstrom L; Rane A
Article: HEART AND VESSELS. 2011;26(6):628-636
Beneficial vasoactive endothelial effects of fluvastatin: focus on prostacyclin and nitric oxide
Skogastierna C; Luksha L; Kublickiene K; Eliasson E; Rane A; Ekstrom L
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2011;96(11):3440-3447
Androgen Sulfation in Healthy UDP-Glucuronosyl Transferase 2B17 Enzyme-Deficient Men
Schulze JJ; Thorngren J-O; Garle M; Ekstrom L; Rane A
Article: PROSTATE. 2011;71(9):909-914
Correlation Between Circulatory, Local Prostatic, and Intra-Prostatic Androgen Levels
Olsson M; Ekstrom L; Guillemette C; Belanger A; Rane A; Gustafsson O
Article: PHARMACOGENETICS AND GENOMICS. 2011;21(6):325-332
Bioavailability of testosterone enanthate dependent on genetic variation in the phosphodiesterase 7B but not on the uridine 5′-diphospho-glucuronosyltransferase (UGT2B17) gene
Ekstrom L; Schulze JJ; Guillemette C; Belanger A; Rane A
Article: PROSTATE. 2010;70(2):200-205
Radical Prostatectomy: Influence on Serum and Urinary Androgen Levels
Olsson M; Ekstrom L; Schulze J; Kjellman A; Akre O; Rane A; Gustafsson O
Article: STEROIDS. 2009;74(12):971-977
Non-steroidal anti-inflammatory drugs interact with testosterone glucuronidation
Sten T; Finel M; Ask B; Rane A; Ekstrom L
Journal article: INVESTIGATIVE UROLOGY. 2009;181(4):720
THE PROSTATE IS AN IMPORTANT SYSTEMIC AND LOCO-REGIONAL ANDROGEN REGULATOR
Olsson M; Gustafsson O; Rane A; Ekström L
Article: CLINICAL CHEMISTRY. 2009;55(4):804-812
Rapid Single-Nucleotide Polymorphism Detection of Cytochrome P450 (CYP2C9) and Vitamin K Epoxide Reductase (VKORC1) Genes for the Warfarin Dose Adjustment by the SMart-Amplification Process Version 2
Aomori T; Yamamoto K; Oguchi-Katayama A; Kawai Y; Ishidao T; Mitani Y; Kogo Y; Lezhava A; Fujita Y; Obayashi K; Nakamura K; Kohnke H; Wadelius M; Ekstrom L; Skogastierna C; Rane A; Kurabayashi M; Murakami M; Cizdziel PE; Hayashizaki Y; Horiuchi R
Article: STEROIDS. 2009;74(3):365-368
Substantial advantage of a combined Bayesian and genotyping approach in testosterone doping tests
Schulze JJ; Lundmark J; Garle M; Ekstroem L; Sottas P-E; Rane A
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2008;93(7):2500-2506
Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation
Schulze JJ; Lundmark J; Garle M; Skilving I; Ekstrom L; Rane A
Article: PHARMACOGENETICS AND GENOMICS. 2008;18(6):477-485
Genetic aspects of epitestosterone formation and androgen disposition:: influence of polymorphisms in CYP17 and UGT2B enzymes
Schulze JJ; Lorentzon M; Ohlsson C; Lundmark J; Roh H-K; Rane A; Ekstrom L
Article: PROSTATE. 2008;68(5):571-575
The UGT2B17 gene deletion is not associated with prostate cancer risk
Olsson M; Lindstrom S; Haggkvist B; Adami H-O; Balter K; Stattin P; Ask B; Rane A; Ekstrom L; Gronberg H
Article: PHARMACOGENOMICS JOURNAL. 2008;8(2):147-151
Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate
Karypidis A-H; Olsson M; Andersson S-O; Rane A; Ekstrom L
Article: PROSTATE. 2007;67(13):1439-1446
Regulation and expression of human CYP7131 in prostate:: Overexpression of CYP7131 during progression of prostatic adenocarcinoma
Olsson M; Gustafsson O; Skogastierna C; Tolf A; Du Rietz B; Morfin R; Rane A; Ekstrom L
Article: PHARMACOGENOMICS JOURNAL. 2007;7(4):282-289
A novel polymorphism in the 17β-hydroxysteroid dehydrogenase type 5 (aldo-keto reductase 1C3) gene is associated with lower serum testosterone levels in caucasian men
Jakobsson J; Palonek E; Lorentzon M; Ohlsson C; Rane A; Ekstrom L
Article: JOURNAL OF LIPID RESEARCH. 2007;48(4):944-951
Novel route for elimination of brain oxysterols across the blood-brain barrier:: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid
Meaney S; Heverin M; Panzenboeck U; Ekstrom L; Axelsson M; Andersson U; Diczfalusy U; Pikuleva I; Wahren J; Sattler W; Bjorkhem I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(7):3810-3820
Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1) -: Marked insensitivity toward different regulatory axes
Ohyama Y; Meaney S; Heverin M; Ekström L; Brafman A; Shafir M; Andersson U; Olin M; Eggertsen G; Diczfalusy U; Feinstein E; Björkhem I
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2006;91(2):687-693
Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism
Jakobsson J; Ekström L; Inotsume N; Garle M; Lorentzon M; Ohlsson C; Roh HK; Carlström K; Rane A
Article: PHARMACOGENOMICS JOURNAL. 2004;4(4):245-250
A functional C-G polymorphism in the CYP7B1 promoter region and its different distribution in Orientals and Caucasians
Jakobsson J; Karypidis H; Johansson JE; Roh HK; Rane A; Ekström L
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1627(2-3):79-84
Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3
Ekström L; Lyrenäs L; Jakobsson PJ; Morgenstern R; Kelner MJ
Article: JOURNAL OF HYPERTENSION. 2002;20(8):1543-1550
Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin-angiotensin-aldosterone system
Iliadou A; Lichtenstein P; Morgenstern R; Forsberg L; Svensson R; de Faire U; Martin NG; Pedersen NL
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2001;30(5):500-505
A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels
Forsberg L; Lyrenäs L; de Faire U; Morgenstern R
Article: BLOOD CELLS, MOLECULES, AND DISEASES. 2000;26(5):423-426
Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1
Forsberg L; de Faire U; Marklund SL; Andersson PM; Stegmayr B; Morgenstern R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(17):13000-13006
Structural organization of the microsomal glutathione S-Transferase gene (MGST1) on chromosome 12p13.1-13.2 -: Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress
Kelner MJ; Bagnell RD; Montoya MA; Estes LA; Forsberg L; Morgenstern R
Article: FEBS LETTERS. 2000;471(1):78-82
Human glutathione dependent prostaglandin E synthase:: gene structure and regulation
Forsberg L; Leeb L; Thorén S; Morgenstern R; Jakobsson PJ
Article: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY. 2000;31(2):107-112
Direct analysis of single-nucleotide polymorphism on double-stranded DNA by pyrosequencing
Nordström T; Ronaghi M; Forsberg L; de Faire U; Morgenstern R; Nyrén P
Article: JOURNAL OF INTERNAL MEDICINE. 1999;246(2):211-218
A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development
Boerma M; Forsberg L; Van Zeijl L; Morgenstern R; De Faire U; Lemne C; Erlinge D; Thulin T; Hong Y; Cotgreave IA
Article: THE FEBS JOURNAL. 1999;260(2):409-413
Distribution of microsomal glutathione transferase 1 in mammalian tissues - A predominant alternate first exon in human tissues
Estonius M; Forsberg L; Danielsson O; Weinander R; Kelner MJ; Morgenstern R
Article: HUMAN MUTATION. 1999;13(4):294-300
Low yield of polymorphisms from EST blast searching: Analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1
Forsberg L; de Faire U; Morgenstern R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(14):8871-8877
Structural and functional aspects of rat microsomal glutathione transferase - The roles of cysteine 49, arginine 107, lysine 67, histidine, and tyrosine residues
Weinander R; Ekstrom L; Andersson C; Raza H; Bergman T; Morgenstern R
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1996;228(1):165-170
Membrane topology of recombinant rat liver microsomal glutathione transferase expressed in E-coli
Raza H; Weinander R; Ekstrom L; Morgenstern R
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Preprint: BIORXIV. 2021
MiRNA and Erythropoietin profiles during the menstrual cycle in relation to hematological and lipid biomarkers
Bergström H; Heiland C; Björkhem-Bergman L; Ekström L
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:63
TESTOSTERONE REDUCES CIRCULATING PCSK9 BUT DOES NOT INFLUENCE CHOLESTEROL OR BILE ACID SYNTHESIS IN HEALTHY MALES
Laskar MG; Beckman L; Laskar A; Garevik N; Ekstrom L; Rudling M; Angelin B
Conference publication: EPILEPSIA. 2018;59:S214
Effect Of UGT1A4 And 2B7 Polymorphisms On Lamotrigine Glucuronidation In Epilepsy Patients
Petrenaite V; Ohman I; Ekstrom L; Bertilsson L; Jantzen FT; Saebye D; Tomson T; Sabers A
Conference publication: GYNECOLOGICAL ENDOCRINOLOGY. 2016;32:48
Digit ratio (2D: 4D ratio) in female Olympic athletes in relation to urinary steroid profile
Lindgren E; Mullen J; Ekstrom L; Hirschberg A
Conference publication: EPILEPSIA. 2016;57:68
EFFECT OF UGT1A4 AND UGT2B7 POLYMORPHISM ON LAMOTRIGINE METABOLISM DURING PREGNANCY
Petrenaite V; Ohman I; Ekstrom L; Bertilsson L; Saebye D; Tomson T; Sabers A
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2016;23:504
Effect of UGT1A4 and UGT2B7 polymorphism on lamotrigine metabolism during pregnancy
Petrenaite V; Ohman I; Ekstrom L; Bertilsson L; Saebye D; Tomson T; Sabers A
Published conference paper: DRUG TESTING AND ANALYSIS. 2015;7(11-12):1063-1070
Dose-dependent testosterone sensitivity of the steroidal passport and GC-C-IRMS analysis in relation to the UGT2B17 deletion polymorphism
Strahm E; Mullen JE; Garevik N; Ericsson M; Schulze JJ; Rane A; Ekstrom L
Editorial comment: FRONTIERS IN ENDOCRINOLOGY. 2015;6:50
Editorial: Variation in phase II metabolism of sex steroids - causes and consequences
Schulze JJ; Ekstrom L
Review: LAKARTIDNINGEN. 2012;109(29-31):1347-1349
[Introduction of genetic analysis can provide us with safer doping tests. Large variation in androgen turnover creates problems in current tests].
Rane A; Ekström L
Review: IN VIVO. 2012;26(4):527-535
Exploring Anticarcinogenic Agents in a Rat Hepatocarcinogenesis Model - Focus on Selenium and Statins
Bjorkhem-Bergman L; Ekstrom L; Eriksson LC
Conference publication: LUMINESCENCE. 2012;27(2):141
Whole-cell bioluminescent biosensors for on-site antidoping screening
Michelini E; Cevenini L; Canali C; Ekstroem L; Schulze J; Garle M; Rane A; Roda A
Review: EXPERT OPINION ON DRUG METABOLISM AND TOXICOLOGY. 2009;5(7):731-744
Genetic variation in androgen disposition: implications in clinical medicine including testosterone abuse
Schulze JJ; Rane A; Ekstrom L
Conference publication: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2009;105:44
THE PLEIOTROPIC EFFECTS OF FLUVASTATIN IN HUMAN VASCULAR ENDOTHELIUM
Skogastierna C; Luksha L; Kublickiene K; Eliasson E; Rane A; Ekstrom L
Book chapter: OXIDATIVE STRESS, DISEASE AND CANCER. 2006;p. 371-460
Oxidative Stress, Genetic Variation, and Disease
Lyrenäs L; Zotova E; Ekström L; Morgenstern R
Conference publication: ACTA PHARMACOLOGICA SINICA. 2006;27:231
Large differences in testosterone excretion in Asian and Caucasian men associated with an UGT2B17 polymorphism-implications for doping tests
Rane A; Jakobsson J; Ekström L; Inotsume N; Garle M; Lorentzon M; Ohlsson C; Roh HK; Carlström K
Review: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2001;389(1):84-93
Oxidative stress, human genetic variation, and disease
Forsberg L; de Faire U; Morgenstern R
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):301-303
Structure and transcriptional regulation of the human microsomal glutathione transferase 1 (MGST1) and prostaglandin E synthase (PGES) genes
Forsberg L; Persson L; Kelner MJ; Jakobsson PJ; Morgenstern R

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Adjungerad Professor, Laboratoriemedicin, Karolinska Institutet, 2022-2026

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Docent, Molekylär genetik, Karolinska Institutet, 2006
MEDICINE DOKTORSEXAMEN, Institutet för miljömedicin, Karolinska Institutet, 2000

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