Lars Norlen

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2023;63(15):4900-4911
Understanding Drug Skin Permeation Enhancers Using Molecular Dynamics Simulations
Wennberg C; Lundborg M; Lindahl E; Norlen L
Article: BIOPHYSICAL JOURNAL. 2022;121(20):3837-3849
Skin permeability prediction with MD simulation sampling spatial and alchemical reaction coordinates
Lundborg M; Wennberg C; Lidmar J; Hess B; Lindahl E; Norlen L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(51):e2100687118
A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen.
Landegren N; Ishii N; Aranda-Guillén M; Gunnarsson HI; Sardh F; Hallgren Å; Ståhle M; Hagforsen E; Bradley M; Edqvist P-HD; Pontén F; Mäkitie O; Eidsmo L; Norlén L; Achour A; Dahlbom I; Korponay-Szabó I; Agardh D; Alimohammadi M; Eriksson D; Hashimoto T; Kämpe O
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(5):1243-1253.e6
Molecular Reorganization during the Formation of the Human Skin Barrier Studied In Situ
Narangifard A; Wennberg CL; den Hollander L; Iwai I; Han H; Lundborg M; Masich S; Lindahl E; Daneholt B; Norlen L
Article: JOURNAL OF CONTROLLED RELEASE. 2018;283:269-279
Predicting drug permeability through skin using molecular dynamics simulation
Lundborg M; Wennberg CL; Narangifard A; Lindahl E; Norlen L
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2018;203(2):149-161
Human skin barrier structure and function analyzed by cryo-EM and molecular dynamics simulation
Lundborg M; Narangifard A; Wennberg CL; Lindahl E; Daneholt B; Norlen L
Article: EXPERIMENTAL CELL RESEARCH. 2018;366(2):139-151
Human skin barrier formation takes place via a cubic to lamellar lipid phase transition as analyzed by cryo-electron microscopy and EM-simulation
Narangifard A; den Hollander L; Wennberg CL; Lundborg M; Lindahl E; Iwai I; Han H; Masich S; Daneholt B; Norlen L
Article: BIOPHYSICAL JOURNAL. 2018;114(5):1116-1127
Structural Transitions in Ceramide Cubic Phases during Formation of the Human Skin Barrier
Wennberg CL; Narangifard A; Lundborg M; Norlen L; Lindahl E
Article: BRITISH JOURNAL OF DERMATOLOGY. 2017;176(4):1021-1027
Acute skin and hair symptoms followed by severe, delayed eye complications in subjects using the synthetic opioid MT-45
Helander A; Bradley M; Hasselblad A; Norlen L; Vassilaki I; Backberg M; Lapins J
Article: ACTA DERMATO-VENEREOLOGICA. 2016;96(3):303-308
Skin Lamellar Bodies are not Discrete Vesicles but Part of a Tubuloreticular Network
den Hollander L; Han H; de Winter M; Svensson L; Masich S; Daneholt B; Norlen L
Article: LAKARTIDNINGEN. 2016;113:DTAF
[Acute cutaneous symptom complex with subsequent cataract. The internet drug MT-45 may be the cause].
Bradley M; Hasselblad A; Norlen L; Lapins J; Bäckberg M; Helander A
Article: SKIN PHARMACOLOGY AND PHYSIOLOGY. 2013;26(4-6):213-216
Current Understanding of Skin Barrier Morphology
Norlen L
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132(9):2215-2225
The Human Skin Barrier Is Organized as Stacked Bilayers of Fully Extended Ceramides with Cholesterol Molecules Associated with the Ceramide Sphingoid Moiety
Iwai I; Han H; den Hollander L; Svensson S; Oefverstedt L-G; Anwar J; Brewer J; Bloksgaard M; Laloeuf A; Nosek D; Masich S; Bagatolli LA; Skoglund U; Norlen L
Article: SKIN PHARMACOLOGY AND PHYSIOLOGY. 2011;24(4):190-198
Sorption Properties of the Human Stratum Corneum
Johnsen GK; Norlen L; Martinsen OG; Grimnes S
Article: JOURNAL OF MICROSCOPY. 2009;235(3):293-307
Molecular cryo-electron tomography of vitreous tissue sections: current challenges
Norlen L; Oktem O; Skoglund U
Article: BIOPHYSICAL JOURNAL. 2007;93(9):3142-3155
Direct visualization of lipid domains in human skin stratum corneum's lipid membranes: Effect of pH and temperature
Plasencia I; Norlen L; Bagatolli LA
Article: INTERNATIONAL JOURNAL OF COSMETIC SCIENCE. 2007;29(5):335-352
Nanostructure of the stratum corneum extracellular lipid matrix as observed by cryo-electron microscopy of vitreous skin sections.
Norlén L
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2007;158(3):386-400
Human stratum corneum lipid organization as observed by atomic force microscopy on Langmuir-Blodgett films
Norlen L; Gil IP; Simonsen A; Descouts P
Article: INTERNATIONAL JOURNAL OF COSMETIC SCIENCE. 2006;28(6):397-425
Stratum corneum keratin structure, function and formation - a comprehensive review.
Norlén L
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2006;156(3):461-468
A procedure to deposit fiducial markers on vitreous cryo-sections for cellular tomography
Masich S; Ostberg T; Norlen L; Shupliakov O; Daneholt B
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2005;124(4):764-777
Nanostructure of the epidermal extracellular space as observed by cryo-electron microscopy of vitreous sections of human skin
Al-Amoudi A; Dubochet J; Norlén L
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2004;123(4):715-732
Stratum corneum keratin structure, function, and formation:: The cubic rod-packing and membrane templating model
Norlén L; Al-Amoudi A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(7):5621-5629
Role for ELOVL3 and fatty acid chain length in development of hair and skin function
Westerberg R; Tvrdik P; Undén AB; Månsson JE; Norlén L; Jakobsson A; Holleran WH; Elias PM; Asadi A; Flodby P; Toftgård R; Capecchi MR; Jacobsson A
Article: SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY. 2003;16(4):203-211
Molecular skin barrier models and some central problems for the understanding of skin barrier structure and function
Norlén L
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2003;120(4):555-560
A cryotransmission electron microscopy study of skin barrier formation
Norlén L; Al-Amoudi A; Dubochet J
Article: JOURNAL OF CONTROLLED RELEASE. 2000;63(1-2):213-226
Structure-related aspects on water diffusivity in fatty acid-soap and skin lipid model systems
Norlén L; Engblom J
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1999;113(4):533-540
A new computer-based evaporimeter system for rapid and precise measurements of water diffusion through stratum corneum in vitro
Norlén L; Engblom J; Andersson M; Forslind B
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1999;112(1):72-77
Inter- and intra-individual differences in human stratum corneum lipid content related to physical parameters of skin barrier function in vivo
Norlén L; Nicander I; Rozell BL; Ollmar S; Forslind B
Article: SKIN RESEARCH AND TECHNOLOGY. 1998;4(4):213-221
Electrical impedance and other physical parameters as related to lipid content of human stratum corneum.
Nicander I; Norlen L; Brockstedt U; Rozell BL; Forslind B; Ollmar S
Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 1998;290(9):508-516
A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction
Norlen L; Nicander I; Lundsjo A; Cronholm T; Forslind B
Article: CURRENT PROBLEMS IN DERMATOLOGY. 1998;26:165-176
Lipid content and electrical impedance
Nicander I; Norlén L; Forslind B; Ollmar S
Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 1997;289(9):506-513
Stratum corneum swelling. Biophysical and computer assisted quantitative assessments
Norlen L; Emilson A; Forslind B
Article: JOURNAL OF DERMATOLOGICAL SCIENCE. 1997;14(2):115-125
A novel approach to the understanding of human skin barrier function
Forslind B; Engstrom S; Engblom J; Norlen L
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Alla övriga publikationer

Review: ACTA DERMATO-VENEREOLOGICA. 2023;103:adv13356
Molecular Organization of the Skin Barrier
Norlen L
Review: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(2):285-292
The Skin's Barrier: A Cryo-EM Based Overview of its Architecture and Stepwise Formation
Norlen L; Lundborg M; Wennberg C; Narangifard A; Daneholt B
Editorial comment: ACTA DERMATO-VENEREOLOGICA. 2016;96(3):291
Is Oil a Balsam for Baby Skin?
Norlen L
Review: BRITISH JOURNAL OF DERMATOLOGY. 2014;171:13-18
Update of technologies for examining the stratum corneum at the molecular level
Norlen L
Review: INTERNATIONAL JOURNAL OF COSMETIC SCIENCE. 2008;30(6):391-411
Stratum corneum lipid organization as observed by atomic force, confocal and two-photon excitation fluorescence microscopy.
Norlén L; Plasencia I; Bagatolli L
Review: EUROPEAN JOURNAL OF DERMATOLOGY. 2008;18(3):279-284
Exploring skin structure using cryo-electron microscopy and tomography
Norlen L
Review: EXPERIMENTAL CELL RESEARCH. 2007;313(10):2217-2227
Structural analysis of vimentin and keratin intermediate filaments by cryo-electron tomography
Norlen L; Masich S; Goldie KN; Hoenger A
Thesis / dissertation: 1999
The skin barrier : structure and physical function
Norlén, Lars Petter Oskar

Anställningar

Anknuten till Forskning, Medicin, Solna, Karolinska Institutet, 2022-2025

Examina och utbildning

Docent, Experimentell dermatologi, Karolinska Institutet, 2004
MEDICINE DOKTORSEXAMEN, Institutionen för medicinsk biokemi och biofysik, Karolinska Institutet, 1999
Läkarexamen, Karolinska Institutet, 1994

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Anställningar

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