Lars Norlen

Publications
CV
Public outreach and news

Articles

Article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2023;63(15):4900-4911
Understanding Drug Skin Permeation Enhancers Using Molecular Dynamics Simulations
Wennberg C; Lundborg M; Lindahl E; Norlen L
Article: BIOPHYSICAL JOURNAL. 2022;121(20):3837-3849
Skin permeability prediction with MD simulation sampling spatial and alchemical reaction coordinates
Lundborg M; Wennberg C; Lidmar J; Hess B; Lindahl E; Norlen L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(51):e2100687118
A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen.
Landegren N; Ishii N; Aranda-Guillén M; Gunnarsson HI; Sardh F; Hallgren Å; Ståhle M; Hagforsen E; Bradley M; Edqvist P-HD; Pontén F; Mäkitie O; Eidsmo L; Norlén L; Achour A; Dahlbom I; Korponay-Szabó I; Agardh D; Alimohammadi M; Eriksson D; Hashimoto T; Kämpe O
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(5):1243-1253.e6
Molecular Reorganization during the Formation of the Human Skin Barrier Studied In Situ
Narangifard A; Wennberg CL; den Hollander L; Iwai I; Han H; Lundborg M; Masich S; Lindahl E; Daneholt B; Norlen L
Article: JOURNAL OF CONTROLLED RELEASE. 2018;283:269-279
Predicting drug permeability through skin using molecular dynamics simulation
Lundborg M; Wennberg CL; Narangifard A; Lindahl E; Norlen L
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2018;203(2):149-161
Human skin barrier structure and function analyzed by cryo-EM and molecular dynamics simulation
Lundborg M; Narangifard A; Wennberg CL; Lindahl E; Daneholt B; Norlen L
Article: EXPERIMENTAL CELL RESEARCH. 2018;366(2):139-151
Human skin barrier formation takes place via a cubic to lamellar lipid phase transition as analyzed by cryo-electron microscopy and EM-simulation
Narangifard A; den Hollander L; Wennberg CL; Lundborg M; Lindahl E; Iwai I; Han H; Masich S; Daneholt B; Norlen L
Article: BIOPHYSICAL JOURNAL. 2018;114(5):1116-1127
Structural Transitions in Ceramide Cubic Phases during Formation of the Human Skin Barrier
Wennberg CL; Narangifard A; Lundborg M; Norlen L; Lindahl E
Article: BRITISH JOURNAL OF DERMATOLOGY. 2017;176(4):1021-1027
Acute skin and hair symptoms followed by severe, delayed eye complications in subjects using the synthetic opioid MT-45
Helander A; Bradley M; Hasselblad A; Norlen L; Vassilaki I; Backberg M; Lapins J
Article: ACTA DERMATO-VENEREOLOGICA. 2016;96(3):303-308
Skin Lamellar Bodies are not Discrete Vesicles but Part of a Tubuloreticular Network
den Hollander L; Han H; de Winter M; Svensson L; Masich S; Daneholt B; Norlen L
Article: LAKARTIDNINGEN. 2016;113:DTAF
[Acute cutaneous symptom complex with subsequent cataract. The internet drug MT-45 may be the cause].
Bradley M; Hasselblad A; Norlen L; Lapins J; Bäckberg M; Helander A
Article: SKIN PHARMACOLOGY AND PHYSIOLOGY. 2013;26(4-6):213-216
Current Understanding of Skin Barrier Morphology
Norlen L
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132(9):2215-2225
The Human Skin Barrier Is Organized as Stacked Bilayers of Fully Extended Ceramides with Cholesterol Molecules Associated with the Ceramide Sphingoid Moiety
Iwai I; Han H; den Hollander L; Svensson S; Oefverstedt L-G; Anwar J; Brewer J; Bloksgaard M; Laloeuf A; Nosek D; Masich S; Bagatolli LA; Skoglund U; Norlen L
Article: SKIN PHARMACOLOGY AND PHYSIOLOGY. 2011;24(4):190-198
Sorption Properties of the Human Stratum Corneum
Johnsen GK; Norlen L; Martinsen OG; Grimnes S
Article: JOURNAL OF MICROSCOPY. 2009;235(3):293-307
Molecular cryo-electron tomography of vitreous tissue sections: current challenges
Norlen L; Oktem O; Skoglund U
Article: BIOPHYSICAL JOURNAL. 2007;93(9):3142-3155
Direct visualization of lipid domains in human skin stratum corneum's lipid membranes: Effect of pH and temperature
Plasencia I; Norlen L; Bagatolli LA
Article: INTERNATIONAL JOURNAL OF COSMETIC SCIENCE. 2007;29(5):335-352
Nanostructure of the stratum corneum extracellular lipid matrix as observed by cryo-electron microscopy of vitreous skin sections.
Norlén L
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2007;158(3):386-400
Human stratum corneum lipid organization as observed by atomic force microscopy on Langmuir-Blodgett films
Norlen L; Gil IP; Simonsen A; Descouts P
Article: INTERNATIONAL JOURNAL OF COSMETIC SCIENCE. 2006;28(6):397-425
Stratum corneum keratin structure, function and formation - a comprehensive review.
Norlén L
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2006;156(3):461-468
A procedure to deposit fiducial markers on vitreous cryo-sections for cellular tomography
Masich S; Ostberg T; Norlen L; Shupliakov O; Daneholt B
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2005;124(4):764-777
Nanostructure of the epidermal extracellular space as observed by cryo-electron microscopy of vitreous sections of human skin
Al-Amoudi A; Dubochet J; Norlén L
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2004;123(4):715-732
Stratum corneum keratin structure, function, and formation:: The cubic rod-packing and membrane templating model
Norlén L; Al-Amoudi A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(7):5621-5629
Role for ELOVL3 and fatty acid chain length in development of hair and skin function
Westerberg R; Tvrdik P; Undén AB; Månsson JE; Norlén L; Jakobsson A; Holleran WH; Elias PM; Asadi A; Flodby P; Toftgård R; Capecchi MR; Jacobsson A
Article: SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY. 2003;16(4):203-211
Molecular skin barrier models and some central problems for the understanding of skin barrier structure and function
Norlén L
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2003;120(4):555-560
A cryotransmission electron microscopy study of skin barrier formation
Norlén L; Al-Amoudi A; Dubochet J
Article: JOURNAL OF CONTROLLED RELEASE. 2000;63(1-2):213-226
Structure-related aspects on water diffusivity in fatty acid-soap and skin lipid model systems
Norlén L; Engblom J
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1999;113(4):533-540
A new computer-based evaporimeter system for rapid and precise measurements of water diffusion through stratum corneum in vitro
Norlén L; Engblom J; Andersson M; Forslind B
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1999;112(1):72-77
Inter- and intra-individual differences in human stratum corneum lipid content related to physical parameters of skin barrier function in vivo
Norlén L; Nicander I; Rozell BL; Ollmar S; Forslind B
Article: SKIN RESEARCH AND TECHNOLOGY. 1998;4(4):213-221
Electrical impedance and other physical parameters as related to lipid content of human stratum corneum.
Nicander I; Norlen L; Brockstedt U; Rozell BL; Forslind B; Ollmar S
Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 1998;290(9):508-516
A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction
Norlen L; Nicander I; Lundsjo A; Cronholm T; Forslind B
Article: CURRENT PROBLEMS IN DERMATOLOGY. 1998;26:165-176
Lipid content and electrical impedance
Nicander I; Norlén L; Forslind B; Ollmar S
Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 1997;289(9):506-513
Stratum corneum swelling. Biophysical and computer assisted quantitative assessments
Norlen L; Emilson A; Forslind B
Article: JOURNAL OF DERMATOLOGICAL SCIENCE. 1997;14(2):115-125
A novel approach to the understanding of human skin barrier function
Forslind B; Engstrom S; Engblom J; Norlen L
Show more

All other publications

Review: ACTA DERMATO-VENEREOLOGICA. 2023;103:adv13356
Molecular Organization of the Skin Barrier
Norlen L
Review: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(2):285-292
The Skin's Barrier: A Cryo-EM Based Overview of its Architecture and Stepwise Formation
Norlen L; Lundborg M; Wennberg C; Narangifard A; Daneholt B
Editorial comment: ACTA DERMATO-VENEREOLOGICA. 2016;96(3):291
Is Oil a Balsam for Baby Skin?
Norlen L
Review: BRITISH JOURNAL OF DERMATOLOGY. 2014;171:13-18
Update of technologies for examining the stratum corneum at the molecular level
Norlen L
Review: INTERNATIONAL JOURNAL OF COSMETIC SCIENCE. 2008;30(6):391-411
Stratum corneum lipid organization as observed by atomic force, confocal and two-photon excitation fluorescence microscopy.
Norlén L; Plasencia I; Bagatolli L
Review: EUROPEAN JOURNAL OF DERMATOLOGY. 2008;18(3):279-284
Exploring skin structure using cryo-electron microscopy and tomography
Norlen L
Review: EXPERIMENTAL CELL RESEARCH. 2007;313(10):2217-2227
Structural analysis of vimentin and keratin intermediate filaments by cryo-electron tomography
Norlen L; Masich S; Goldie KN; Hoenger A
Thesis / dissertation: 1999
The skin barrier : structure and physical function
Norlén, Lars Petter Oskar

Employments

Affiliated to Research, Department of Medicine, Karolinska Institutet, 2022-2025

Degrees and Education

Docent, Karolinska Institutet, 2004
Doctor Of Philosophy, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 1999
University Medical Degree, Karolinska Institutet, 1994

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI