Keying Zhu

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Journal article: NATURE NEUROSCIENCE. 2026;:1-15
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration
Zhu K; Liu Y; Min J-H; Joshua V; Lin J; Li Y; Kreutzmann JC; Guo Y; Xia W; Mohammadi E; Pieber M; Suerth V; Xia Y; Andrusivova Z; Hugnot J-P; Kanatani S; Uhlen P; Lundeberg J; Li X; Fancy SPJ; Sarlus H; Harris RA; Lund H
Journal article: CELL DEATH AND DIFFERENTIATION. 2025;32(12):2368-2383
GSDME-mediated pyroptosis in microglia exacerbates demyelination and neuroinflammation in multiple sclerosis: insights from humans and cuprizone-induced demyelination model mice
Wang D; Zhang T; Shao Q; Wu X; Zhao X; Zhang H; Wang Y; Sun J; Chang X; Zhu K; Wu S; Cao L; Chen W; Wang J
Article: NATURE NANOTECHNOLOGY. 2024;19(9):1366-1374
A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns
Wang Y; Baars I; Berzina I; Rocamonde-Lago I; Shen B; Yang Y; Lolaico M; Waldvogel J; Smyrlaki I; Zhu K; Harris RA; Hogberg B
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2024;221(2):e20230675
CD163⁺ macrophages monitor enhanced permeability at the blood-dorsal root ganglion barrier
Lund H; Hunt MA; Kurtovic Z; Sandor K; Kagy PB; Fereydouni N; Julien A; Goritz C; Vazquez-Liebanas E; Andaloussi Mae M; Jurczak A; Han J; Zhu K; Harris RA; Lampa J; Graversen JH; Etzerodt A; Haglund L; Yaksh TL; Svensson CI
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2024;127:111408
Sanguinarine modulates microglial function via PPARγ activation and protects against CNS demyelination
Wang D-J; Wang X; Li S-L; Zhang T-T; Yang Y-C; Wang Y-M; Zhao X-Q; Li K-Y; Li Y; Zhu K-Y; Wang J
Journal article: TRANSPLANTATION. 2023;107(10):49
Human Amnion Epithelial Cells reduce disease progression in a mouse model for multiple sclerosis
Sarlus H; Zhu K; Guo Y; Balasingh VJ; Min J-H; Cuesta IB; Bencina S; Harris R; Gramignoli R
Article: JCI INSIGHT. 2023;8(17):e167656
Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations
Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Adori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; Mcinerney G; Murrell B; Aoun M; Baeckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Hedestam GBK; Dopico XC; Rorbach J
Article: ACTA PHARMACOLOGICA SINICA. 2023;44(4):766-779
Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function
Sun J-X; Zhu K-Y; Wang Y-M; Wang D-J; Zhang M-Z; Sarlus H; Benito-Cuesta I; Zhao X-Q; Zou Z-F; Zhong Q-Y; Feng Y; Wu S; Wang Y-Q; Harris RA; Wang J
Article: JOURNAL OF NEUROINFLAMMATION. 2023;20(1):83
Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination
Wang Y; Sun J; Zhu K; Wang D; Zhao X; Zhang H; Wu S; Wang Y; Wang J
Article: EMBO REPORTS. 2022;23(7):e54499
Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation
Zhu K; Wang Y; Sarlus H; Geng K; Nutma E; Sun J; Kung S-Y; Bay C; Han J; Min J-H; Benito-Cuesta I; Lund H; Amor S; Wang J; Zhang X-M; Kutter C; Guerreiro-Cacais AO; Hogberg B; Harris RA
Article: JOURNAL OF NEUROINFLAMMATION. 2022;19(1):20
An overlooked subset of Cx3cr1^wt/wt microglia in the Cx3cr1^{CreER-Eyfp/wt} mouse has a repopulation advantage over Cx3cr1^{CreER-Eyfp/wt} microglia following microglial depletion
Zhou K; Han J; Lund H; Boggavarapu NR; Lauschke VM; Goto S; Cheng H; Wang Y; Tachi A; Xie C; Zhu K; Sun Y; Osman AM; Liang D; Han W; Gemzell-Danielsson K; Betsholtz C; Zhang X-M; Zhu C; Enge M; Joseph B; Harris RA; Blomgren K
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2021;99(3):793-805
Axonal mitochondria adjust in size depending on g-ratio of surrounding myelin during homeostasis and advanced remyelination
Ineichen BV; Zhu K; Carlstrom KE
Article: CARBOHYDRATE POLYMERS. 2021;254:117291
Harnessing hyaluronic acid-based nanoparticles for combination therapy: A novel approach for suppressing systemic inflammation and to promote antitumor macrophage polarization
Rangasami VK; Samanta S; Parihar VS; Asawa K; Zhu K; Varghese OP; Teramura Y; Nilsson B; Hilborn J; Harris RA; Oommen OP
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(22):E8603-8603
Underestimated Peripheral Effects Following Pharmacological and Conditional Genetic Microglial Depletion
Han J; Fan Y; Zhou K; Zhu K; Blomgren K; Lund H; Zhang X-M; Harris RA
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(18):E6824-6824
Sex-Specific Effects of Microglia-Like Cell Engraftment during Experimental Autoimmune Encephalomyelitis
Han J; Zhu K; Zhou K; Hakim R; Sankavaram SR; Blomgren K; Lund H; Zhang X-M; Harris RA
Article: NATURE COMMUNICATIONS. 2020;11(1):4071
Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis
Carlstrom KE; Zhu K; Ewing E; Krabbendam IE; Harris RA; Falcao AM; Jagodic M; Castelo-Branco G; Piehl F
Article: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2020;2020:3205176
Tyrosine Kinase Receptors Axl and MerTK Mediate the Beneficial Effect of Electroacupuncture in a Cuprizone-Induced Demyelinating Model
Zou Z; Sun J; Kang Z; Wang Y; Zhao H; Zhu K; Wang J
Article: GLIA. 2020;68(7):1466-1478
Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice
Zhu K; Pieber M; Han J; Blomgren K; Zhang X-M; Harris RA; Lund H
Article: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2019;4:27
miR-124/VAMP3 is a novel therapeutic target for mitigation of surgical trauma-induced microglial activation
Chen Y; Sun J-X; Chen W-K; Wu G-C; Wang Y-P; Zhu K-Y; Wang J
Article: BRAIN RESEARCH. 2019;1710:33-42
Repurposing of omeprazole for oligodendrocyte differentiation and remyelination
Zhu K; Sun J; Kang Z; Zou Z; Wu X; Wang Y; Wu G; Harris RA; Wang J
Article: NATURE IMMUNOLOGY. 2018;19(5):1-7
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
Lund H; Pieber M; Parsa R; Grommisch D; Ewing E; Kular L; Han J; Zhu K; Nijssen J; Hedlund E; Needhamsen M; Ruhrmann S; Guerreiro-Cacais AO; Berglund R; Forteza MJ; Ketelhuth DFJ; Butovsky O; Jagodic M; Zhang X-M; Harris RA
Journal article: BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2017;40(8):1306-1313
Polyphyllin I Overcomes EMT-Associated Resistance to Erlotinib in Lung Cancer Cells via IL-6/STAT3 Pathway Inhibition
Lou W; Chen Y; Zhu K-Y; Deng H; Wu T; Wang J
Journal article: FRONTIERS IN NEUROSCIENCE. 2017;10:613
Electroacupuncture Promotes Remyelination after Cuprizone Treatment by Enhancing Myelin Debris Clearance
Zhu K; Sun J; Kang Z; Zou Z; Wu G; Wang J
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Alla övriga publikationer

Preprint: BIORXIV. 2025
Human placental stem cells induce a novel multiple myeloid cell-driven immunosuppressive program that ameliorates proinflammatory CNS pathology
Sarlus H; Guo Y; Bencina S; Zhu K; Balasingh VJ; Virgilio GA; Cheng Y; Lin J; Min J-H; Benito-Cuesta I; Suerth V; Alonso PT; Thomas O; Rykaczewska U; Guerreiro Cacais AO; Jagodic M; Gramignoli R; Harris R
Preprint: BIORXIV. 2023
Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cord
Zhu K; Min J-H; Joshua V; Liu Y; Pieber M; Suerth V; Sarlus H; Harris R; Lund H
Doctoral thesis: 2023
Deciphering and fine-tuning of myeloid cells in CNS demyelinating conditions
Zhu K
Preprint: BIORXIV. 2023
A network of CD163⁺macrophages monitors enhanced permeability at the blood-dorsal root ganglion barrier
Lund H; Hunt M; Kurtovic Z; Sandor K; Fereydouni N; Julien A; Göritz C; Han J; Zhu K; Harris R; Lampa J; Haglund L; Yaksh T; Svensson C
Preprint: BIORXIV. 2021
Nanoengineered DNA origami with repurposed TOP1 inhibitors targeting myeloid cells for the mitigation of neuroinflammation
Zhu K; Wang Y; Sarlus H; Geng K; Nutma E; Sun J; Kung S-Y; Bay C; Han J; Lund H; Amor S; Wang J; Zhang X; Kutter C; Guerreiro Cacais AO; Högberg B; Harris R
Preprint: BIORXIV. 2020
Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas/Casp8/Bid-axis
Carlström K; Zhu K; Ewing E; Krabbendam I; Harris R; Falcão AM; Jagodic M; Castelo-Branco G; Piehl F
Preprint: BIORXIV. 2019
Axonal mitochondria across species adjust in diameter depending on thickness of surrounding myelin
Ineichen B; Zhu K; Carlström K
Review: GLIA. 2019;67(2):217-231
Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders
Han J; Zhu K; Zhang X-M; Harris RA

Forskningsbidrag

Cellulära och molekylära mekanismer bakom selektiv myelinsårbarhet
MS-Forskningsfonden
1 January 2026 - 31 December 2027
Transcriptional Coregulators in Control of Microglial Function in CNS Demyelinating Diseases
Neuroförbundet
1 January 2024 - 31 December 2024
Oligodendroglial Primary Cilia in White Matter Injury Repair: Function, Signaling mechanism, and Proteome Repertoire
Swedish Research Council
1 January 2024 - 31 December 2026
Nya immunterapier för neurodegenerativa sjukdomar
Swedish Research Council
1 December 2021 - 30 November 2026
Novel immunotherapy targeting myeloid cells for neurological diseases: Drug repurposing and nanoengineering
StratNeuro
1 June 2021 - 31 May 2023
Novel immunotherapy for neuroinflammation: drug repurposing and nanoengineering for myeloid cells
Neuroförbundet
1 January 2021 - 1 January 2022

Anställningar

Postdoktor, Klinisk neurovetenskap, Karolinska Institutet, 2023-2026

Examina och utbildning

Medicine Doktorsexamen, Institutionen för klinisk neurovetenskap, Karolinska Institutet, 2023

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