Keying Zhu

Keying Zhu

Postdoctoral Researcher
Visiting address: L8:04, CMM Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postal address: K8 Klinisk neurovetenskap, K8 Neuro Harris, 171 77 Stockholm

Research

  • My current research interest lies in the field of neuroimmunology with a main focus on multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease (AD). I'm currently a postdoctoral researcher in Robert Harris's group, and we are trying to understand the role of microglia and peripheral-derived macrophages in CNS disorders. We aim to develop strategies to combat neuroinflammatory disorders by regulating dysfunctional microglia and other myeloid cells.

    (Master's students with relevant expertise and experience in animal experiments are welcome to contact us for internship opportunities.)

    Currently, I'm leading the following projects:
    1. Drug repurposing and nanoengineering for neuroinflammatory diseases.
    2. Deciphering the TGF-β signaling in microglia.
    3. Corepressor complexes in the regulation of microglial function and the CNS homeostasis.
    4. The TRPV1 receptor in demyelination and remyelination.

Teaching

  • Supervised 4 master students for their master project reports:

    Timas Shin-Yu Kung (8 months, Karolinska Institutet)
    Projects: 1. Microglial reprogramming for neuroinflammatory disorders
  • 2. Topoisomerase 1
    inhibition mitigates microglial activation and neuroinflammation.

    Cindy Bay (2 months, Heidelberg University)
    Project: Topoisomerase 1 inhibition attenuates neuroinflammation.

    Zoë Keasberry (6 months, Vrije Universiteit Amsterdam)
    Project: Improvement of microglial replacement therapy in severe neurological diseases:
    understanding the depletion and repopulation pattern of microglia following CSF1R inhibition.

    Yiming Xia (10 months, Karolinska Institutet)
    Projection: Transcritptional coregulator in control of microglia function.

Articles

All other publications

Grants

Employments

  • Postdoctoral Researcher, Department of Clinical Neuroscience, Karolinska Institutet, 2023-2025

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2023

News from KI

Events from KI