Karin Loré

About me
Publications
CV
Public outreach and news

About me

Karin Loré, professor i vaccinationsimmunologi med inriktning mot det medfödda immunsvaret vid institutionen för medicin, Solna, forskar om hur immunförsvaret reagerar på vaccinering och hur skydd mot infektionssjukdomar byggs upp. Särskilt fokuserar hon på hur nya immunstimulerande substanser, adjuvans, kan ge starkare svar. På sikt hoppas hon att kunskapen ska bidra till vaccin mot sjukdomar som HIV/AIDS och malaria.

Teaching

Karin Loré, Professor of Vaccination Immunology specialising in Innate Immunity at the Department of Medicine, Solna, studies how the immune system responds to vaccination and how protective responses to infectious diseases are established. In particular, she focuses on how immune-stimulating substances – vaccine adjuvants – can induce stronger responses which is important for the development of vaccines to infections like hiv/aids and malaria.

Articles

Journal article: EMERGING MICROBES & INFECTIONS. 2024;13(1):2309985
Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques
Huang L; Zhao T; Zhao W; Shao A; Zhao H; Ma W; Gong Y; Zeng X; Weng C; Bu L; Di Z; Sun S; Dai Q; Sun M; Wang L; Liu Z; Shi L; Hu J; Fang S; Zhang C; Zhang J; Wang G; Lore K; Yang Y; Lin A
Article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2023;1524(1):65-86
Progress in vaccine development for infectious diseases-a Keystone Symposia report
Cable J; Graham BS; Koup RA; Seder RA; Kariko K; Pardi N; Barouch DH; Sharma B; Rauch S; Nachbagauer R; Forsell MNE; Schotsaert M; Ellebedy AH; Lore K; Irvine DJ; Pilkington E; Tahtinen S; Thompson EA; Feraoun Y; King NP; Saunders K; Alter G; Moin SM; Sliepen K; Karlsson Hedestam GB; Wardemann H; Pulendran B; Doria-Rose NA; He W-T; Juno JA; Ataca S; Wheatley AK; McLellan JS; Walker LM; Lederhofer J; Lindesmith LC; Wille H; Hotez PJ; Bekker L-G
Article: NATURE COMMUNICATIONS. 2023;14(1):2164
Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19
Yu M; Charles A; Cagigi A; Christ W; osterberg B; Falck-Jones S; Azizmohammadi L; ahlberg E; Falck-Jones R; Svensson J; Nie M; Warnqvist A; Hellgren F; Lenart K; Arcoverde Cerveira R; Ols S; Lindgren G; Lin A; Maecker H; Bell M; Johansson N; Albert J; Sundling C; Czarnewski P; Klingstroem J; Faernert A; Lore K; Smed-Soerensen A
Article: PLOS NEGLECTED TROPICAL DISEASES. 2023;17(2):e0010616
Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial.
Sandberg JT; Löfling M; Varnaitė R; Emgård J; Al-Tawil N; Lindquist L; Gredmark-Russ S; Klingström J; Loré K; Blom K; Ljunggren H-G
Article: MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT. 2022;27:309-323
A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses
Lenart K; Hellgren F; Ols S; Yan X; Cagigi A; Cerveira RA; Winge I; Hanczak J; Mueller SO; Jasny E; Schwendt K; Rauch S; Petsch B; Lore K
Article: IMMUNITY. 2022;55(9):1732-1746.e5
Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination
Gao Y; Cai C; Wullimann D; Niessl J; Rivera-Ballesteros O; Chen P; Lange J; Cuapio A; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Perez-Potti A; Sekine T; Muller TR; Boulouis C; Kammann T; Parrot T; Muvva JR; Sobkowiak M; Healy K; Bogdanovic G; Muschiol S; Soderdahl G; Osterborg A; Hellgren F; Grifoni A; Weiskopf D; Sette A; Lore K; Chen MS; Ljungman P; Sandberg JK; Smith CIE; Bergman P; Ljunggren H-G; Aleman S; Buggert M
Article: MED. 2022;3(2):137-153.e3
Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals
Healy K; Pin E; Chen P; Soderdahl G; Nowak P; Mielke S; Hansson L; Bergman P; Smith CIE; Ljungman P; Valentini D; Blennow O; Osterborg A; Gabarrini G; Al-Manei K; Alkharaan H; Sobkowiak MJ; Yousef J; Mravinacova S; Cuapio A; Xu X; Akber M; Lore K; Hellstrom C; Muschiol S; Bogdanovic G; Buggert M; Ljunggren H-G; Hober S; Nilsson P; Aleman S; Chen MS
Article: MOLECULAR MEDICINE. 2022;28(1):20
NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals
Cuapio A; Boulouis C; Filipovic I; Wullimann D; Kammann T; Parrot T; Chen P; Akber M; Gao Y; Hammer Q; Strunz B; Potti AP; Ballesteros OR; Lange J; Muvva JR; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Soderdahl G; Osterborg A; Smith CIE; Bogdanovic G; Muschiol S; Hellgren F; Lore K; Sobkowiak MJ; Gabarrini G; Healy K; Chen MS; Alici E; Bjorkstrom NK; Buggert M; Ljungman P; Sandberg JK; Aleman S; Ljunggren H-G
Article: EBIOMEDICINE. 2021;74:103705
Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial
Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Chen P; Soderdahl G; Osterborg A; Smith CIE; Wullimann D; Vesterbacka J; Lindgren G; Blixt L; Friman G; Wahren-Borgstrom E; Nordlander A; Gomez AC; Akber M; Valentini D; Norlin A-C; Thalme A; Bogdanovic G; Muschiol S; Nilsson P; Hober S; Lore K; Chen MS; Buggert M; Ljunggren H-G; Ljungman P; Aleman S
Article: JCI INSIGHT. 2021;6(22):e151463
Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination
Cagigi A; Yu M; Osterberg B; Svensson J; Falck-Jones S; Vangeti S; Ahlberg E; Azizmohammadi L; Warnqvist A; Falck-Jones R; Gubisch PC; Odemis M; Ghafoor F; Eisele M; Lenart K; Bell M; Johansson N; Albert J; Salde J; Pettie DD; Murphy MP; Carter L; King NP; Ols S; Normark J; Ahlm C; Forsell MN; Farnert A; Lore K; Smed-Sorensen A
Article: IMMUNITY. 2021;54(9):2005-2023.e10
Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response
Glaros V; Rauschmeier R; Artemov AV; Reinhardt A; Ols S; Emmanouilidi A; Gustafsson C; You Y; Mirabello C; Bjorklund AK; Perez L; King NP; Mansson R; Angeletti D; Lore K; Adameyko I; Busslinger M; Kreslavsky T
Article: JOURNAL OF IMMUNOLOGY. 2021;207(4):1033-1043
Activation and Kinetics of Circulating T Follicular Helper Cells, Specific Plasmablast Response, and Development of Neutralizing Antibodies following Yellow Fever Virus Vaccination
Sandberg JT; Ols S; Lofling M; Varnait R; Lindgren G; Nilsson O; Rombo L; Kale M; Lore K; Blom K; Ljunggren H-G; Lindgren G; Nilsson O; Rombo L; Kale M
Article: CELL REPORTS MEDICINE. 2021;2(4):100252
SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses
Mandolesi M; Sheward DJ; Hanke L; Ma J; Pushparaj P; Vidakovics LP; Kim C; Adori M; Lenart K; Lore K; Dopico XC; Coquet JM; McInerney GM; Hedestam GBK; Murrell B
Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(6):144734
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity
Falck-Jones S; Vangeti S; Yu M; Falck-Jones R; Cagigi A; Badolati I; Osterberg B; Lautenbach MJ; Ahlberg E; Lin A; Lepzien R; Szurgot I; Lenart K; Hellgren F; Maecker H; Salde J; Albert J; Johansson N; Bell M; Lore K; Farnert A; Smed-Sorensen A
Article: NATURE COMMUNICATIONS. 2021;12(1):1510
Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain
Kupari J; Usoskin D; Parisien M; Lou D; Hu Y; Fatt M; Lonnerberg P; Spangberg M; Eriksson B; Barkas N; Kharchenko PV; Lore K; Khoury S; Diatchenko L; Ernfors P
Article: METHODS IN MOLECULAR BIOLOGY. 2021;2236:9-17
Phenotyping of Myeloid-Derived Suppressor Cells in Nonhuman Primates.
Lin A; Loré K
Article: ELIFE. 2020;9:e60528
A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites
Bhandage AK; Olivera GC; Kanatani S; Thompson E; Lore K; Varas-Godoy M; Barragan A
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2020;8(2):e001223
Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation
Cassetta L; Bruderek K; Skrzeczynska-Moncznik J; Osiecka O; Hu X; Rundgren IM; Lin A; Santegoets K; Horzum U; Godinho-Santos A; Zelinskyy G; Garcia-Tellez T; Bjelica S; Taciak B; Kittang AO; Hoeing B; Lang S; Dixon M; Mueller V; Utikal JS; Karakoc D; Yilmaz KB; Gorka E; Bodnar L; Anastasiou OE; Bourgeois C; Badura R; Kapinska-Mrowiecka M; Gotic M; ter Laan M; Kers-Rebel E; Krol M; Santibanez JF; Mueller-Trutwin M; Dittmer U; de Sousa AE; Esendagli G; Adema G; Lore K; Ersvaer E; Umansky V; Pollard JW; Cichy J; Brandau S
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2020;481:112792
Stabilization of blood for long-term storage can affect antibody-based recognition of cell surface markers
Silva MH; Lepzien R; Ols S; Dahlberg B; Grunewald J; Lore K; Smed-Sorensen A; Correia-Neves M; Empadinhas N; Farnert A; Kallenius G; Sundling C
Article: SCIENCE ADVANCES. 2020;6(19):eaaz2433
A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates
Stone VM; Hankaniemi MM; Laitinen OH; Sioofy-Khojine AB; Lin A; Lozano IMD; Mazur MA; Marjomaki V; Lore K; Hyoty H; Hytonen VP; Flodstrom-Tullberg M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(5):2332-2346
Live attenuated pertussis vaccine BPZE1 induces a broad antibody response in humans
Lin A; Apostolovic D; Jahnmatz M; Liang F; Ols S; Tecleab T; Wu C; van Hage M; Solovay K; Rubin K; Locht C; Thorstensson R; Thalen M; Lore K
Article: JOURNAL OF INFECTIOUS DISEASES. 2020;221(8):1295-1303
Recurrent Herpes Zoster Ophthalmicus in a Patient With a Novel Toll-Like Receptor 3 Variant Linked to Compromised Activation Capacity in Fibroblasts
Liang F; Glans H; Enoksson SL; Kolios AGA; Lore K; Nilsson J
Article: CELL REPORTS. 2020;30(12):3964-3971.e7
Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity
Ols S; Yang L; Thompson EA; Pushparaj P; Tran K; Liang F; Lin A; Eriksson B; Hedestam GBK; Wyatt RT; Lore K
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2020;9(7):e1150
Deficits in the IgG⁺ memory B-cell recovery after anthracycline treatment is confined to the spleen of rhesus macaques
Lasaviciute G; Bricaud AL; Hellgren F; Ingelman-Sundberg HM; Eksborg S; Jonker M; Haanstra KG; Hed Myrberg I; Sverremark-Ekstrom E; Lore K; Saghafian-Hedengren S; Nilsson A
Article: PLOS PATHOGENS. 2019;15(12):e1008121
ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type
Schifanella L; Barnett SW; Bissa M; Galli V; Doster MN; Vaccari M; Tomaras GD; Shen X; Phogat S; Pal R; Montefiori DC; LaBranche CC; Rao M; Trinh HV; Washington-Parks R; Liyanage NPM; Brown DR; Liang F; Lore K; Venzon DJ; Magnanelli W; Metrinko M; Kramer J; Breed M; Alter G; Ruprecht RM; Franchini G
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2019;472:16-24
Comparative analysis of the germinal center response by flow cytometry and immunohistology
Lindgren G; Ols S; Thompson EA; Lore K
Article: CELL REPORTS. 2019;28(5):1127-1135.e4
Monocytes Acquire the Ability to Prime Tissue-Resident T Cells via IL-10-Mediated TGF-β Release
Thompson EA; Darrah PA; Foulds KE; Hoffer E; Caffrey-Carr A; Norenstedt S; Perbeck L; Seder RA; Kedl RM; Lore K
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2019;68(4):687-697
Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates
Cassetta L; Baekkevold ES; Brandau S; Bujko A; Cassatella MA; Dorhoi A; Krieg C; Lin A; Lore K; Marini O; Pollard JW; Roussel M; Scapini P; Umansky V; Adema GJ
Article: CELL. 2019;176(6):1420-1431.e17
Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus
Marcandalli J; Fiala B; Ols S; Perotti M; de van der Schueren W; Snijder J; Hodge E; Benhaim M; Ravichandran R; Carter L; Sheffler W; Brunner L; Lawrenz M; Dubois P; Lanzavecchia A; Sallusto F; Lee KK; Veesler D; Correnti CE; Stewart LJ; Baker D; Lore K; Perez L; King NP
Article: JCI INSIGHT. 2018;3(10):120692
TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25
Thompson EA; Ols S; Miura K; Rausch K; Narum DL; Spangberg M; Juraska M; Wille-Reece U; Weiner A; Howard RF; Long CA; Duffy PE; Johnston L; O'neil CP; Lore K
Article: JOURNAL OF IMMUNOLOGY. 2018;200(1):286-294
Rhesus Macaque Myeloid-Derived Suppressor Cells Demonstrate T Cell Inhibitory Functions and Are Transiently Increased after Vaccination
Lin A; Liang F; Thompson EA; Vono M; Ols S; Lindgren G; Hassett K; Salter H; Ciaramella G; Lore K
Article: MOLECULAR THERAPY. 2017;25(12):2635-2647
Efficient Targeting and Activation of Antigen Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques
Liang F; Lindgren G; Lin A; Thompson EA; Ols S; Rohss J; John S; Hassett K; Yuzhakov O; Bahl K; Brito LA; Salter H; Ciaramella G; Lore K
Article: SCIENCE TRANSLATIONAL MEDICINE. 2017;9(393):eaal2094
Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake
Liang F; Lindgren G; Sandgren KJ; Thompson EA; Francica JR; Seubert A; De Gregorio E; Barnett S; O'Hagan DT; Sullivan NJ; Koup RA; Seder RA; Lore K
Article: IMMUNITY. 2017;46(5):804-817.e7
Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach
Martinez-Murillo P; Tran K; Guenaga J; Lindgren G; Adori M; Feng Y; Phad GE; Bernat NV; Bale S; Ingale J; Dubrovskaya V; O'Dell S; Pramanik L; Spangberg M; Corcoran M; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
Article: BLOOD. 2017;129(14):1991-2001
Neutrophils acquire the capacity for antigen presentation to memory CD4⁺ T cells in vitro and ex vivo
Vono M; Lin A; Norrby-Teglund A; Koup RA; Liang F; Lore K
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1539
Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+CXCR3+T Follicular Helper Cells
Lindgren G; Ols S; Liang F; Thompson EA; Lin A; Hellgren F; Bahl K; John S; Yuzhakov O; Hassett KJ; Brito LA; Salter H; Ciaramella G; Lore K
Article: NATURE MEDICINE. 2016;22(7):762-770
Adjuvant-dependent innate and adaptive immune signatures of risk of SIV_mac251 acquisition
Vaccari M; Gordon SN; Fourati S; Schifanella L; Liyanage NPM; Cameron M; Keele BF; Shen X; Tomaras GD; Billings E; Rao M; Chung AW; Dowell KG; Bailey-Kellogg C; Brown EP; Ackerman ME; Vargas-Inchaustegui DA; Whitney S; Doster MN; Binello N; Pegu P; Montefiori DC; Foulds K; Quinn DS; Donaldson M; Liang F; Lore K; Roederer M; Koup RA; McDermott A; Ma Z-M; Miller CJ; Phan TB; Forthal DN; Blackburn M; Caccuri F; Bissa M; Ferrari G; Kalyanaraman V; Ferrari MG; Thompson D; Robert-Guroff M; Ratto-Kim S; Kim JH; Michael NL; Phogat S; Barnett SW; Tartaglia J; Venzon D; Stablein DM; Alter G; Sekaly R-P; Franchini G
Article: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2015;496(2):371-381
Design and evaluation of surface and adjuvant modified PLGA microspheres for uptake by dendritic cells to improve vaccine responses
Salvador A; Sandgren KJ; Liang F; Thompson EA; Koup RA; Pedraz JL; Maria Hernandez R; Lore K; Igartua M
Journal article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3497-3498
Correction: Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates.
Thompson EA; Liang F; Lindgren G; Sandgren KJ; Quinn KM; Darrah PA; Koup RA; Seder RA; Kedl RM; Loré K
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2015;425:69-78
Dissociation of skeletal muscle for flow cytometric characterization of immune cells in macaques
Liang F; Ploquin A; Hernandez JD; Fausther-Bovendo H; Lindgren G; Stanley D; Salvador Martinez A; Brenchley JM; Koup RA; Lore K; Sullivan NJ
Article: JOURNAL OF IMMUNOLOGY. 2015;195(3):1015-1024
Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates
Thompson EA; Liang F; Lindgren G; Sandgren KJ; Quinn KM; Darrah PA; Koup RA; Seder RA; Kedl RM; Lore K
Journal article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30(S1):a64-a65
Adjuvant Dependent Mucosal V2 Responses and RAS Activation in Vaccine Induced Protection from SIVmac251 Acquisition
Vaccari M; Gordon SN; Fourati S; Schifanella L; Cameron M; Keele BF; Shen X; Tomaras G; Billings E; Rao M; Liyanage NPM; Vargas-Inchaustegui DA; Whitney S; Doster MN; Binello N; Pegu P; Montefiori DC; Foulds K; Quinn DS; Donaldson M; Liang F; Lore K; Roederer M; Koup R; McDermott A; Ma Z-M; Christopher M; Phan TB; Forthal DN; Blackburn M; Caccuri F; Ferrari G; Robert-Guroff M; Ratto-Kim S; Kim J; Michael N; Phogat S; Barnett SW; Tartaglia J; Venzon D; Stablein DM; Sekaly R-P; Franchini G
Article: IMMUNITY. 2014;41(3):493-502
Tissue Myeloid Cells in SIV-Infected Primates Acquire Viral DNA through Phagocytosis of Infected T Cells
Calantone N; Wu F; Klase Z; Deleage C; Perkins M; Matsuda K; Thompson EA; Ortiz AM; Vinton CL; Ourmanov I; Lore K; Douek DC; Estes JD; Hirsch VM; Brenchley JM
Journal article: CELL STEM CELL. 2014;14(4):486-499
Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.
Wu C; Li B; Lu R; Koelle SJ; Yang Y; Jares A; Krouse AE; Metzger M; Liang F; Loré K; Wu CO; Donahue RE; Chen ISY; Weissman I; Dunbar CE
Article: VACCINE. 2014;32(6):717-724
Type I interferon-dependent activation of NK cells by rAd28 or rAd35, but not rAd5, leads to loss of vector-insert expression
Johnson MJ; Bjorkstrom NK; Petrovas C; Liang F; Gall JGD; Lore K; Koup RA
Article: JOURNAL OF IMMUNOLOGY. 2013;191(10):5085-5096
Coadministration of Polyinosinic: Polycytidylic Acid and Immunostimulatory Complexes Modifies Antigen Processing in Dendritic Cell Subsets and Enhances HIV Gag-Specific T Cell Immunity
Quinn KM; Yamamoto A; Costa A; Darrah PA; Lindsay RWB; Hegde ST; Johnson TR; Flynn BJ; Lore K; Seder RA
Article: VIROLOGY. 2013;446(1-2):56-65
Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants
Feng Y; Forsell MNE; Flynn B; Adams W; Lore K; Seder R; Wyatt RT; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):60-69
Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation
Sandgren KJ; Smed-Sorensen A; Forsell MN; Soldemo M; Adams WC; Liang F; Perbeck L; Koup RA; Wyatt RT; Hedestam GBK; Lore K
Article: JOURNAL OF AUTOIMMUNITY. 2013;42:62-70
AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment
Lindmark E; Chen Y; Georgoudaki A-M; Dudziak D; Lindh E; Adams WC; Lore K; Winqvist O; Chambers BJ; Karlsson MCI
Article: AIDS. 2013;27(7):1071-1080
Dendritic cell recruitment in response to skin antigen tests in HIV-1-infected individuals correlates with the level of T-cell infiltration
Liang F; Bond E; Sandgren KJ; Smed-Sorensen A; Rangaka MX; Lange C; Koup RA; McComsey GA; Lederman MM; Wilkinson RJ; Andersson J; Lore K
Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2013;762:263-288
Targeting Dendritic Cells for Improved HIV-1 Vaccines
Smed-Sorensen A; Lore K
Article: JOURNAL OF IMMUNOLOGY. 2012;188(12):6109-6118
Type I IFN Induced by Adenovirus Serotypes 28 and 35 Has Multiple Effects on T Cell Immunogenicity
Johnson MJ; Petrovas C; Yamamoto T; Lindsay RWB; Lore K; Gall JGD; Gostick E; Lefebvre F; Cameron MJ; Price DA; Haddad E; Sekaly R-P; Seder RA; Koup RA
Article: JOURNAL OF GENERAL VIROLOGY. 2012;93(Pt 6):1339-1344
Attenuation of CD4⁺ T-cell function by human adenovirus type 35 is mediated by the knob protein
Adams WC; Berenson RJ; Hedestam GBK; Lieber A; Koup RA; Lore K
Article: METHODS IN MOLECULAR BIOLOGY. 2012;820:215-230
In vitro stimulation and detection of IFNα production in human plasmacytoid dendritic cells.
Adams WC; Loré K
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132(1):114-123
Plasmacytoid Dendritic Cells Infiltrate the Skin in Positive Tuberculin Skin Test Indurations
Bond E; Liang F; Sandgren KJ; Smed-Sorensen A; Bergman P; Brighenti S; Adams WC; Betemariam SA; Rangaka MX; Lange C; Wilkinson RJ; Andersson J; Lore K
Article: IMMUNOLOGY. 2011;134(3):257-269
Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation
Gujer C; Sundling C; Seder RA; Hedestam GBK; Lore K
Article: CURRENT OPINION IN HIV AND AIDS. 2011;6(5):405-410
Dendritic cells at the interface of innate and adaptive immunity to HIV-1
Smed-Sorensen A; Lore K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(18):7499-7504
Adenovirus type-35 vectors block human CD4⁺ T-cell activation via CD46 ligation
Adams WC; Gujer C; McInerney G; Gall JGD; Petrovas C; Hedestam GBK; Koup RA; Lore K
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2011;89(6):811-821
IFN-α produced by human plasmacytoid dendritic cells enhances T cell-dependent naive B cell differentiation
Gujer C; Sandgren KJ; Douagi I; Adams WC; Sundling C; Smed-Sorensen A; Seder RA; Hedestam GBK; Lore K
Journal article: CLINICAL NUTRITION. 2011;6(1):109
PP226-SUN FISH OIL DOES NOT MODULATE THE RESPONSE OF IN VIVO PROTEIN SYNTHESIS IN IMMUNE CELLS TO ENDOTOXIN IN HEALTHY VOLUNTEERS
Januszkiewicz A; Claude M; Concha H; Hebert C; Lore K; Andersson J; Rooyackers O; Wernerman J
Article: JOURNAL OF VIROLOGY. 2010;84(18):9086-9095
Immunization with Wild-Type or CD4-Binding-Defective HIV-1 Env Trimers Reduces Viremia Equivalently following Heterologous Challenge with Simian-Human Immunodeficiency Virus
Sundling C; O'Dell S; Douagi I; Forsell MN; Morner A; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(9):2003-2017
Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates
Sundling C; Forsell MNE; O'Dell S; Feng Y; Chakrabarti B; Rao SS; Lore K; Mascola JR; Wyatt RT; Douagi I; Hedestam GBK
Article: JOURNAL OF VIROLOGY. 2010;84(4):1683-1695
Influence of Novel CD4 Binding-Defective HIV-1 Envelope Glycoprotein Immunogens on Neutralizing Antibody and T-Cell Responses in Nonhuman Primates
Douagi I; Forsell MNE; Sundling C; O'Dell S; Feng Y; Dosenovic P; Li Y; Seder R; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGY. 2009;183(6):4047-4054
Neutrophil-Derived Hyperresistinemia in Severe Acute Streptococcal Infections
Johansson L; Linner A; Sunden-Cullberg J; Haggar A; Herwald H; Lore K; Treutiger C-J; Norrby-Teglund A
Article: CURRENT OPINION IN HIV AND AIDS. 2009;4(5):441-446
Novel adjuvants for B cell immune responses
Lore K; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2009;348(1-2):42-56
Techniques for time-efficient isolation of human skin dendritic cell subsets and assessment of their antigen uptake capacity
Bond E; Adams WC; Smed-Sorensen A; Sandgren KJ; Perbeck L; Hofmann A; Andersson J; Lore K
Article: JOURNAL OF GENERAL VIROLOGY. 2009;90(Pt 7):1600-1610
Adenovirus serotype 5 infects human dendritic cells via a coxsackievirus-adenovirus receptor-independent receptor pathway mediated by lactoferrin and DC-SIGN
Adams WC; Bond E; Havenga MJE; Holterman L; Goudsmit J; Hedestam GBK; Koup RA; Lore K
Article: INFECTION AND IMMUNITY. 2009;77(4):1679-1688
The Toxoplasma gondii-Shuttling Function of Dendritic Cells Is Linked to the Parasite Genotype
Lambert H; Vutova PP; Adams WC; Lore K; Barragan A
Article: JOURNAL OF IMMUNOLOGY. 2009;182(4):1991-2001
Human B Cell Responses to TLR Ligands Are Differentially Modulated by Myeloid and Plasmacytoid Dendritic Cells
Douagi I; Gujer C; Sundling C; Adams WC; Smed-Soerensen A; Seder RA; Hedestam GBK; Lore K
Article: BLOOD. 2008;111(10):5037-5046
IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcγRIIa
Smed-Sorensen A; Moll M; Cheng T-Y; Lore K; Norlin A-C; Perbeck L; Moody DB; Spetz A-L; Sandberg JK
Article: JOURNAL OF VIROLOGY. 2007;81(24):13486-13498
Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection
Duvall MG; Lore K; Blaak H; Ambrozak DA; Adams WC; Santos K; Geldmacher C; Mascola JR; McMichael AJ; Jaye A; Whittle HC; Rowland-Jones SL; Koup RA
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2007;27(6):589-597
Enhanced In vivo protein synthesis in circulating immune cells of ICU patients
Januszkiewicz A; Klaude M; Lore K; Andersson J; Ringden O; Rooyackers O; Wernerman J
Article: JOURNAL OF IMMUNOLOGY. 2007;179(3):1721-1729
Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses
Lore K; Adams WC; Havenga MJE; Precopio ML; Holterman L; Goudsmit J; Koup RA
Article: BLOOD. 2007;110(1):441-449
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.
Seggewiss R; Loré K; Guenaga FJ; Pittaluga S; Mattapallil J; Chow CK; Koup RA; Camphausen K; Nason MC; Meier-Schellersheim M; Donahue RE; Blazar BR; Dunbar CE; Douek DC
Article: STEM CELLS. 2006;24(6):1539-1548
In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaques.
Loré K; Seggewiss R; Guenaga FJ; Pittaluga S; Donahue RE; Krouse A; Metzger ME; Koup RA; Reilly C; Douek DC; Dunbar CE
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2006;203(5):1249-1258
Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates.
Wille-Reece U; Flynn BJ; Loré K; Koup RA; Miles AP; Saul A; Kedl RM; Mattapallil JJ; Weiss WR; Roederer M; Seder RA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(42):15190-15194
HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.
Wille-Reece U; Flynn BJ; Loré K; Koup RA; Kedl RM; Mattapallil JJ; Weiss WR; Roederer M; Seder RA
Article: JOURNAL OF VIROLOGY. 2005;79(14):8861-8869
Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells
Smed-Sörensen A; Loré K; Vasudevan J; Louder MK; Andersson J; Mascola JR; Spetz AL; Koup RA
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2005;201(12):2023-2033
Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4⁺ T cells
Loré K; Smed-Sörensen A; Vasudevan J; Mascola JR; Koup RA
Article: BLOOD. 2005;105(6):2473-2479
Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner.
Seggewiss R; Loré K; Greiner E; Magnusson MK; Price DA; Douek DC; Dunbar CE; Wiestner A
Article: CLINICAL SCIENCE. 2005;108(2):179-184
Determination of in vivo protein synthesis in human palatine tonsil
Januszkiewicz A; Klaude M; Loré K; Andersson J; Ringdén O; Rooyackers O; Wernerman J
Journal article: BLOOD. 2004;104(11):1342
Proliferation of CD8+ T-Cells Specific for CMV and EBV in Response to TCR Mediated Recognition of Cognate Antigen Is Inhibited by Imatinib in a Dose-Dependent Manner.
Seggewiss R; Lore K; Greiner E; Magnusson MK; Price DA; Douek DC; Dunbar CE; Wiestner A
Journal article: BLOOD. 2004;104(11):1196
In Vitro Culture during Retroviral Transduction Improves Thymic Repopulation and Output after TBI and Autologous PBPC Transplantation in Rhesus Macaques.
Seggewiss R; Lore K; Guenaga JF; Pittaluga S; Metzger ME; Krouse A; Donahue RE; Ambrozak D; Douek DC; Dunbar CE
Article: JOURNAL OF VIROLOGY. 2004;78(21):11980-11987
Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies.
Ganesh L; Leung K; Loré K; Levin R; Panet A; Schwartz O; Koup RA; Nabel GJ
Article: BLOOD. 2004;104(9):2810-2817
HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation
Smed-Sörensen A; Loré K; Walther-Jallow L; Andersson J; Spetz AL
Article: JOURNAL OF IMMUNOLOGY. 2004;172(10):6407-6417
The functional profile of primary human antiviral CD8⁺ T cell effector activity is dictated by cognate peptide concentration
Betts MR; Price DA; Brenchley JM; Loré K; Guenaga FJ; Smed-Sorensen A; Ambrozak DR; Migueles SA; Connors M; Roederer M; Douek DC; Koup RA
Article: JOURNAL OF IMMUNOLOGY. 2004;172(4):2219-2224
HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters.
Sugaya M; Loré K; Koup RA; Douek DC; Blauvelt A
Article: JOURNAL OF MEDICAL PRIMATOLOGY. 2004;33(1):16-24
Dichotomy between CD1a+ and CD83+ dendritic cells in lymph nodes during SIV infection of macaques
Söderlund J; Nilsson C; Loré K; Castanos-Velez E; Ekman M; Heiden T; Biberfeld G; Andersson J; Biberfeld P
Article: METHODS IN MOLECULAR BIOLOGY. 2004;249:201-218
Detection of cytokine- and chemokine-expressing cells at the single cell level.
Loré K; Andersson J
Article: JOURNAL OF IMMUNOLOGY. 2003;171(8):4320-4328
Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses.
Loré K; Betts MR; Brenchley JM; Kuruppu J; Khojasteh S; Perfetto S; Roederer M; Seder RA; Koup RA
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2002;130(2):263-270
Response of in vivo protein synthesis in T lymphocytes and leucocytes to an endotoxin challenge in healthy volunteers
Januszkiewicz A; Loré K; Essén P; Andersson B; McNurlan MA; Garlick PJ; Ringdén O; Andersson J; Wernerman J
Article: AIDS. 2002;16(5):683-692
Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection
Loré K; Sönnerborg A; Broström C; Goh LE; Perrin L; McDade H; Stellbrink HJ; Gazzard B; Weber R; Napolitano LA; van Kooyk Y; Andersson J
Article: JOURNAL OF VIROLOGY. 2001;75(17):8195-8202
Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy
Lane BR; Lore K; Bock PJ; Andersson J; Coffey MJ; Strieter RM; Markovitz DM
Article: PEDIATRIC DERMATOLOGY. 2001;18(3):177-187
Erythema toxicum neonatorum:: An immunohistochemical analysis
Marchini G; Ulfgren AK; Loré K; Ståbi B; Berggren V; Lonne-Rahm S
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2001;249(1-2):207-222
Quantitative single cell methods that identify cytokine and chemokine expression in dendritic cells
Loré K; Spetz AL; Fehniger TE; Sönnerborg A; Landay AL; Andersson J
Article: AIDS. 1999;13(15):2013-2021
HIV-1 exposed dendritic cells show increased pro-inflammatory cytokine production but reduced IL-1ra following lipopolysaccharide stimulation
Loré K; Sönnerborg A; Olsson J; Patterson BK; Fehniger TE; Perbeck L; Andersson J
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 1999;15(14):1249-1254
Long-term effects of antiretroviral combination therapy on HIV type 1 DNA levels
Aleman S; Visco-Comandini U; Loré K; Sönnerborg A
Article: AIDS. 1999;13(11):1295-1303
Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection
Andersson J; Behbahani H; Lieberman J; Connick E; Landay A; Patterson B; Sönnerborg A; Loré K; Uccini S; Fehniger TE
Article: JOURNAL OF IMMUNOLOGY. 1999;163(2):736-742
Functional gene transfer of HIV DNA by an HIV receptor-independent mechanism
Spetz AL; Patterson BK; Lore K; Andersson J; Holmgren L
Article: CLINICAL MICROBIOLOGY AND INFECTION. 1999;5(2):78-87
Determination of cytomegalovirus DNA load for monitoring of cytomegalovirus disease and antiviral treatment in solid organ transplant patients, comparing limiting-dilution PCR and hybrid capture assay with cytomegalovirus isolation.
Barkholt L; Loré K; Tydén G; Lewensohn-Fuchs I; Andersson J; Ericzon B-G; Lundgren G; Ehrnst A
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 1998;214(1-2):97-111
Immunocytochemical detection of cytokines and chemokines in Langerhans cells and in vitro derived dendritic cells
Loré K; Sönnerborg A; Spetz AL; Andersson U; Andersson J
Article: BONE MARROW TRANSPLANTATION. 1996;17(4):583-587
Use of a semi-quantitative PCR for cytomegalovirus DNA as a basis for pre-emptive antiviral therapy in allogeneic bone marrow transplant patients
Ljungman P; Lore K; Aschan J; Klaesson S; LewensohnFuchs I; Lonnqvist B; Ringden O; Winiarski J; Ehrnst A
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Review: IMMUNITY. 2022;55(11):1993-2005
Innate immune mechanisms of mRNA vaccines
Verbeke R; Hogan MJ; Lore K; Pardi N
Review: JOURNAL OF INTERNAL MEDICINE. 2022;291(1):32-50
Immunity to SARS-CoV-2 induced by infection or vaccination
Castro Dopico X; Ols S; Lore K; Karlsson Hedestam GB
Review: VACCINES. 2021;9(1):61
Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
Cagigi A; Lore K
Preprint: MEDRXIV. 2020
Functional myeloid-derived suppressor cells expand in blood but not airways of COVID-19 patients and predict disease severity
Falck-Jones S; Vangeti S; Yu M; Falck-Jones R; Cagigi A; Badolati I; Österberg B; Lautenbach MJ; Åhlberg E; Lin A; Szurgot I; Lenart K; Hellgren F; Sälde J; Albert J; Johansson N; Bell M; Loré K; Färnert A; Smed-Sörensen A
Preprint: BIORXIV. 2020
SARS-CoV-2 protein subunit vaccination elicits potent neutralizing antibody responses
Mandolesi M; Sheward D; Hanke L; Ma J; Pushparaj P; Perez Vidakovics L; Kim C; Loré K; Castro Dopico X; Coquet J; McInerney G; Karlsson Hedestam G; Murrell B
Editorial comment: NATURE BIOMEDICAL ENGINEERING. 2019;3(5):331-332
Imaging the early fate of mRNA vaccines
Ols S; Lore K
Corrigendum: FRONTIERS IN IMMUNOLOGY. 2019;10:614
Induction of Robust B Cell Responses After Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells (vol 8, 1539, 2017)
Lindgren G; Ols S; Liang F; Thompson EA; Lin A; Hellgren F; Bahl K; John S; Yuzhakov O; Hassett KJ; Brito LA; Salter H; Ciaramella G; Lore K
Book chapter: ENCYCLOPEDIA OF AIDS. 2018;p. 446-457
Dendritic Cell Interactions with HIV-1 Envelope Glycoprotein: Implications for Preventing Transmission
Sandgren KJ; Liang F; Smed-Sörensen A; Loré K
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2017;282(3):206-208
Prospects for induction of CD8 T cell-mediated immunity to Zika virus infection by yellow fever virus vaccination
Blom K; Sandberg JT; Lore K; Ljunggren H-G
Review: CURRENT OPINION IN IMMUNOLOGY. 2017;47:1-7
Non-human primates as a model for understanding the mechanism of action of toll-like receptor-based vaccine adjuvants
Thompson EA; Lore K
Review: FRONTIERS IN IMMUNOLOGY. 2017;8:1781
Granulocytes: New Members of the Antigen-Presenting Cell Family
Lin A; Lore K
Review: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2016;5(4):e74
Local innate immune responses in the vaccine adjuvant-injected muscle
Liang F; Lore K
Corrigendum: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(10):2283
Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates (vol 207, pg 2003, 2010)
Sundling C; Forsell MNE; O'Dell S; Feng Y; Chakrabarti B; Rao SS; Lore K; Mascola JR; Wyatt RT; Douagi I; Hedestam GBK
Published conference paper: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 2009;51(3):239-247
Abundant and Superficial Expression of C-Type Lectin Receptors in Ectocervix of Women at Risk of HIV Infection
Hirbod T; Kaldensjoe T; Lopalco L; Klareskog E; Andersson S; Uberti-Foppa C; Ferrari D; Manghi M; Andersson J; Lore K; Broliden K
Meeting abstract: RETROVIROLOGY. 2009;6:p83
Evaluation of peripheral and bone marrow B cell responses in rhesus macaques after immunization with soluble HIV-1 gp140 trimers
Sundling C; Soldemo M; Chakrabarti B; Forsell MN; Lore K; Wyatt RT; Douagi I
Meeting abstract: RETROVIROLOGY. 2009;6:o35
Impact of in vivo CD4 binding during HIV-1 Env trimer immunizations of rhesus macaques
Douagi I; Forsell MM; Sundling C; O'dell S; Seder R; Mascola JR; Lore K; Wyatt RT
Meeting abstract: BLOOD. 2005;106(11):187
Keratinocyte growth factor increases thymic output of naive T-cells after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaques.
Seggewiss R; Lore K; Guenaga FJ; Pittaluga S; Matappallil JJ; Ambrozak D; Bailer RT; Koup RA; Donahue RE; Blazar BR; Hollander GA; Douek DC; Dunbar CE
Review: BIOMOLECULAR INTERACTIONS, PT A. 2004;75:623-642
Isolation and immunophenotyping of human and rhesus macaque dendritic cells.
Loré K
Review: APMIS. 2003;111(7-8):776-788
The role of dendritic cells in the pathogenesis of HIV-1 infection.
Lore K; Larsson M
Thesis / dissertation: 2001
Immunological properties of dendritic cells in HIV-1 infection
Loré, Karin
Corrigendum: JOURNAL OF IMMUNOLOGICAL METHODS. 1998;218(1-2):173-187
Immunocytochemical detection of cytokines and chemokines in Langerhans cells and in vitro derived dendritic cells (vol 214, pg 97, 1998)
Loré K; Sönnerborg A; Spetz AL; Andersson U; Andersson J
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Employments

Professor, Department of Medicine, Karolinska Institutet, 2014-

Degrees and Education

Docent, Karolinska Institutet, 2010
Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2001
Licentiate Degree, Department of Laboratory Medicine, Karolinska Institutet, 1999

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