Karin Leander
Om mig
- Docent i epidemiologi, 2012, vid KI.
Forskargruppsledare vid Institutet för miljömedicin, KI.
Uppdrag inom utbildning, främst för KI Läkarprogram.
Uppdrag inom riskbedömningsverksamhet vid min institution.
Ledamot i Karolinska Institutets Pedagogiska Akademi.
2005, Filosofie doktor (PhD), KI
1999, Magisterexamen folkhälsovetenskap, KI.
1997, Medicine Kandidatexamen, inriktning folkhälsa, KI. Programmets namn: Preventiv Medicin.
1992-1996 Kurser i företagsekonomi, juridik, franska och hälsoekonomi vid Stockholms Universitet och Handelshögskolan.
Forskningsbeskrivning
Min forskning är inom området kardiovaskulär epidemiologi, med ett generellt syfte att öka kunskapen om kardiovaskulära riskfaktorer för att förbättra den vetenskapliga grunden för primär och sekundär prevention hos kvinnor och män. I min forskargrupp har vi specifikt fokus på kardiometabolt relaterade faktorer såsom låggradig inflammation, blodfettsrubbningar, högt blodtryck och diabetes, samt på betydelsen av livsstilsfaktorer, såsom kostvanor, för den kardiovaskulära hälsan.
Vidare har vi ett särskilt intresse för kvinnors hälsa vad gäller möjliga kardiovaskulärt relaterade hälsoeffekter av graviditetskomplikationer, premenstruella spänningar, klimakterierelaterade symptom samt hormonbehandlingar. Ett annat specifikt fokus är utforskande av möjliga interaktioner mellan genetiska faktorer och livsstilsfaktorer i relation till kardiovaskulär risk. De hjärt-kärlsjukdomar vi studerar inkluderar dödliga och icke-dödliga händelser av kranskärlssjukdom och stroke samt aortaaneurysm. Vi studerar även grad av ateroskleros i hjärtats kranskärl.
Pågående projekt
Som huvudsökande / huvudansvarig:
• Vetenskapsrådet (VR): Förstärker en låg andel fleromättat fett i kosten, speglad via biomarkörer, den kardiovaskulära risken förknippad med att ha kardiovaskulär sjukdom i familjen?
• Huvudansvarig för 60-årskohorten.
• Huvudansvarig för Stockholm Heart Epidemiology Program (SHEEP).
• Huvudansvarig för den lokala substudien ”Kvinnoenkäten” inom SCAPIS (Swedish Cardiopulmonary Bioimage study) vid Stockholms respektive • Linköpings SCAPIS-center.• Huvudansvarig för projektet COMPREHEND (Studies of register-based health outcomes in relation to hormonal drugs).
Som medsökande och ”Work Package”-ansvarig:
• National Institutes of Health (NIH), USA: Studier av hur klimakteriet och östrogenreceptoraktivering inverkar på risken att utveckla Alzheimers sjukdom.
Undervisning
- Huvudhandlett 2 doktorander till disputation och har ett pågående huvudhandledaransvar.
Bihandledare för 4 doktorander som disputerat - 4 pågående ansvar som bihandledare.
Handlett 2 postdoktorer och en biträdande lektor. Handlett ett tiotal examensarbeten på avancerad nivå.
Medlem i Curriculumkommittén, 6-åriga läkarprogrammet vid KI, med uppdrag som samordnare för kompetensområdet ”global och jämlik vård och hälsa”.
Kursansvar för kursen ”Hälsa i samhälle och miljö”, Termin 11, 5, 5-åriga läkarprogrammet vid KI.
Medlem i programkollegiet, i roll som ordförande för Tema 7, 5, 5-åriga läkarprogrammet vid KI.
Ingår i Beredningsgruppen för kursplaner, KI läkarprogram.
Promotor för utveckling av interprofessionellt lärande vid KI.
Examinator på kursen Examensarbete i medicin, 5, 5-åriga läkarprogrammet vid KI.
Regelbundet kursansvarig för doktorandkursen Epidemiology II: Design of epidemiological studies, 1, 5 hp och Cardiovascular Epidemiology, 1, 5 hp, vid KI.
Undervisat mer än 800 timmar vid KI varav cirka hälften inom forskarutbildningen och hälften inom grundutbildningen.
Artiklar
- Journal article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2024;13(17):e033648
- Article: EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING. 2024;:jeae217
- Article: ENVIRONMENTAL EPIDEMIOLOGY. 2024;8(4):e319
- Article: ENVIRONMENTAL RESEARCH. 2024;252(Pt 3):118942
- Article: INTERNATIONAL JOURNAL OF CANCER. 2024;154(11):1900-1910
- Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2024;912:168789
- Article: ENVIRONMENTAL POLLUTION. 2024;343:123097
- Article: STROKE. 2024;55(1):50-58
- Article: GLOBAL HEALTH ACTION. 2023;16(1):2190649
- Article: CARDIOVASCULAR RESEARCH (CVR). 2023;119(16):2594-2606
- Article: ENVIRONMENTAL RESEARCH. 2023;239(Pt 1):117230
- Journal article: OBSTETRIC ANESTHESIA DIGEST. 2023;43(4):173
- Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.2634
- Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2023;118(5):921-929
- Article: SCIENTIFIC REPORTS. 2023;13(1):15011
- Article: BRITISH JOURNAL OF CANCER. 2023;129(4):656-664
- Article: JAMA NETWORK OPEN. 2023;6(9):e2333347
- Article: ENVIRONMENT INTERNATIONAL. 2023;178:108108
- Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2023;82(4):336-349
- Article: DIABETOLOGIA. 2023;66(7):1260-1272
- Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2023;16(3):236-247
- Article: ENVIRONMENTAL RESEARCH. 2023;224:115454
- Article: JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (JAMA). 2023;329(5):393-404
- Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2023;32(1):105-113
- Article: ENVIRONMENT INTERNATIONAL. 2023;171:107667
- Article: CURRENT RESEARCH IN TRANSLATIONAL MEDICINE. 2023;71(1):103374
- Article: FRONTIERS IN GENETICS. 2023;14:1235337
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2023;131(1):17003
- Article: ENVIRONMENTAL RESEARCH. 2022;215(Pt 2):114385
- Article: ENVIRONMENT INTERNATIONAL. 2022;170:107581
- Article: OPEN HEART. 2022;9(2):e002082
- Article: OPEN HEART. 2022;9(2):e002080
- Article: ENVIRONMENT INTERNATIONAL. 2022;166:107341
- Article: ENVIRONMENTAL SCIENCE AND TECHNOLOGY. 2022;56(13):9277-9290
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;205(12):1429-1439
- Article: BRITISH JOURNAL OF CANCER. 2022;126(10):1499-1507
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2022;130(3):37007
- Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2022;19(5):2630
- Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2022;9:809007
- Article: FRONTIERS IN PHYSIOLOGY. 2022;13:909870
- Article: THE LANCET PLANETARY HEALTH. 2022;6(1):E9-E18
- Article: PLOS MEDICINE. 2021;18(12):e1003853
- Article: INTERNATIONAL JOURNAL OF CANCER. 2021;149(11):1887-1897
- Article: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (EJPC). 2021;28(12):1376-1385
- Article: OPEN HEART. 2021;8(2):e001694
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2021;129(10):107002
- Article: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (EJPC). 2021;28(11):1229-1234
- Article: BMJ OPEN. 2021;11(9):e046040
- Article: THE BMJ. 2021;374:n1904
- Journal article: ISEE CONFERENCE ABSTRACTS. 2021;2021(1)
- Journal article: ISEE CONFERENCE ABSTRACTS. 2021;2021(1)
- Article: HEART LUNG AND CIRCULATION. 2021;30(7):1050-1057
- Article: EUROPEAN RESPIRATORY JOURNAL. 2021;57(6):2003099
- Article: NATURE GENETICS. 2021;53(6):840-860
- Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2021;10(11):e020419
- Article: MOLECULAR PSYCHIATRY. 2021;26(6):2111-2125
- Journal article: EUROPEAN RESPIRATORY JOURNAL. 2021;57(6):2003099
- Article: NATURE COMMUNICATIONS. 2021;12(1):2329
- Article: SCIENTIFIC REPORTS. 2021;11(1):7866
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2021;129(4):47009
- Article: SCIENTIFIC REPORTS. 2021;11(1):5796
- Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2021;10(5):e019592
- Article: ENVIRONMENTAL RESEARCH. 2021;193:110568
- Article: EUROPEAN JOURNAL OF NUTRITION. 2021;60(1):123-134
- Article: ENVIRONMENT INTERNATIONAL. 2021;146:106267
- Article: ENVIRONMENT INTERNATIONAL. 2021;146:106249
- Journal article: HEART LUNG AND CIRCULATION. 2021;30:s277
- Article: EUROPEAN JOURNAL OF NUTRITION. 2020;59(5):2089-2097
- Article: EUROPEAN HEART JOURNAL. 2020;41(26):2430-2438
- Article: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2020;30(4):730-742
- Article: BIOPRESERVATION AND BIOBANKING. 2020;18(2):122-135
- Article: GENES AND IMMUNITY. 2020;21(2):100-108
- Journal article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2019;58(6):e150
- Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2019;48(6):2018-2025
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2019;127(10):107012
- Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1):ehz746.0018
- Article: HUMAN MOLECULAR GENETICS. 2019;28(15):2615-2633
- Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2019;188(6):1033-1054
- Article: CIRCULATION. 2019;139(21):2422-2436
- Article: NATURE GENETICS. 2019;51(4):636-648
- Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2019;12(4):e002471
- Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2019;12(4):e002470
- Article: BMC CARDIOVASCULAR DISORDERS. 2019;19(1):34
- Article: NATURE COMMUNICATIONS. 2019;10(1):376
- Article: CLINICAL NUTRITION. 2018;37(6):2001-2010
- Article: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 2018;72(10):904-910
- Journal article: EUROPEAN HEART JOURNAL. 2018;39(suppl_1):ehy563.p3645
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2018;102(3):375-400
- Journal article: PROCEEDINGS FOR ANNUAL MEETING OF THE JAPANESE PHARMACOLOGICAL SOCIETY. 2018;WCP2018(0):po3-14-11
- Article: PLOS ONE. 2018;13(6):e0198166
- Article: CARDIOVASCULAR PATHOLOGY. 2018;32:32-37
- Article: NUTRIENTS. 2017;9(12):E1355-1355
- Article: DIABETES. 2017;66(11):2888-2902
- Article: PLOS MEDICINE. 2017;14(11):e1002445
- Journal article: CLINICAL NUTRITION. 2017;36:s55-s56
- Article: SCANDINAVIAN CARDIOVASCULAR JOURNAL. 2017;51(3):167-171
- Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2017;37(suppl_1)
- Article: NATURE COMMUNICATIONS. 2017;8:14977
- Article: PLOS ONE. 2017;12(1):e0170684
- Article: PLOS ONE. 2017;12(4):e0171195
- Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(12):e004415
- Journal article: IJC METABOLIC AND ENDOCRINE. 2016;12:30-35
- Article: JOURNAL OF HUMAN NUTRITION AND DIETETICS. 2016;29(3):325-337
- Journal article: EFSA SUPPORTING PUBLICATIONS. 2016;13(5)
- Article: CIRCULATION. 2016;133(13):1230-1239
- Article: EUROPEAN JOURNAL OF NUTRITION. 2016;55(1):247-255
- Article: NATURE GENETICS. 2015;47(12):1415-1425
- Article: ANNALS OF MEDICINE. 2015;47(8):679-686
- Article: PLOS GENETICS. 2015;11(10):e1005378
- Article: ENVIRONMENT INTERNATIONAL. 2015;82:76-84
- Article: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2015;25(5):517-523
- Journal article: CLINICAL NUTRITION. 2015;34:s216
- Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2015;4(8):e001853
- Article: ATHEROSCLEROSIS. 2015;240(2):477-481
- Article: DIABETOLOGIA. 2015;58(6):1363-1371
- Article: MENOPAUSE. 2015;22(6):598-606
- Article: OBESITY REVIEWS. 2015;16(4):327-340
- Article: CYTOKINE. 2015;72(2):178-184
- Article: ATHEROSCLEROSIS. 2015;239(1):125-130
- Article: NATURE. 2015;518(7538):197-206
- Article: NATURE. 2015;518(7538):187-U378
- Article: ANNALS OF MEDICINE. 2015;47(1):28-33
- Article: PLOS ONE. 2015;10(5):e0127111
- Article: PLOS ONE. 2015;10(7):e0132601
- Article: PREVENTIVE MEDICINE. 2014;69:151-156
- Journal article: ISEE CONFERENCE ABSTRACTS. 2014;2014(1)
- Article: ATHEROSCLEROSIS. 2014;236(2):394-399
- Journal article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2014;48(3):344
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2014;122(9):919-925
- Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2014;34(9):2068-2077
- Article: NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES. 2014;24(8):891-899
- Article: ENVIRONMENT INTERNATIONAL. 2014;66:97-106
- Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2014;7(2):171-177
- Article: BRITISH JOURNAL OF SURGERY. 2014;101(5):481-487
- Article: NATURE GENETICS. 2014;46(3):234-244
- Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2014;172(1):173-178
- Article: BMC PUBLIC HEALTH. 2014;14:17
- Article: ATHEROSCLEROSIS. 2014;232(1):242-248
- Article: HEART. 2013;99(23):1761-1765
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2013;37(12):1579-1585
- Article: STATISTICS IN MEDICINE. 2013;32(27):4726-4747
- Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2013;33(11):2633-2638
- Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2013;168(2):946-952
- Article: BMJ OPEN. 2013;3(9):e003058
- Journal article: EUROPEAN HEART JOURNAL. 2013;34(suppl_1):p1564
- Article: BMC CARDIOVASCULAR DISORDERS. 2013;13:1
- Article: NATURE GENETICS. 2013;45(1):25-33
- Article: PLOS ONE. 2013;8(4):e61763
- Journal article: NATURE GENETICS. 2013;45(1):25-U52
- Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2012;5(6):656-665
- Article: BMC CARDIOVASCULAR DISORDERS. 2012;12:90
- Article: NATURE GENETICS. 2012;44(9):981-990
- Article: HEART. 2012;98(16):1242-1245
- Article: THROMBOSIS RESEARCH. 2012;130(2):221-225
- Article: THROMBOSIS AND HAEMOSTASIS. 2012;107(6):1092-1099
- Article: NATURE GENETICS. 2012;44(6):659-U81
- Article: CLINICA CHIMICA ACTA. 2012;413(7-8):727-732
- Article: EUROPEAN HEART JOURNAL. 2012;33(3):393-407
- Article: ATHEROSCLEROSIS. 2012;220(2):486-492
- Article: JOURNAL OF INTERNAL MEDICINE. 2011;270(3):229-236
- Article: PLOS GENETICS. 2011;7(9):e1002260
- Article: NATURE GENETICS. 2011;43(4):333-338
- Article: NATURE GENETICS. 2011;43(4):339-U89
- Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2010;59(12):1736-1741
- Article: PLOS ONE. 2010;5(6):e11300
- Article: NEW ENGLAND JOURNAL OF MEDICINE. 2009;361(26):2518-2528
- Article: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2009;66(11):747-753
- Journal article: ATHEROSCLEROSIS PLUS. 2009;10(2):e1017
- Article: DIABETES CARE. 2008;31(5):887-892
- Article: JOURNAL OF CARDIOVASCULAR RISK. 2007;14(4):532-537
- Article: JOURNAL OF INTERNAL MEDICINE. 2007;261(2):138-147
- Article: THROMBOSIS RESEARCH. 2005;116(3):223-232
- Article: THROMBOSIS AND HAEMOSTASIS. 2003;89(6):1064-1071
- Article: JOURNAL OF INTERNAL MEDICINE. 2002;252(4):332-341
- Journal article: ATHEROSCLEROSIS. 2000;151(1):125
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Alla övriga publikationer
- Review: ENVIRONMENTAL RESEARCH. 2022;213:113705
- Conference publication: ISEE CONFERENCE ABSTRACTS. 2022;2022(1)
- Corrigendum: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2022;32(5):782
- Review: FRONTIERS IN NUTRITION. 2022;9:875607
- Review: ESSAYS IN BIOCHEMISTRY. 2021;65(6):913-925
- Editorial comment: RESUSCITATION. 2021;168:223-224
- Review: PLOS MEDICINE. 2021;18(9):e1003763
- Conference publication: CIRCULATION. 2021;143:a026
- Preprint: BIORXIV. 2020
- Corrigendum: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2020;30(4):768
- Conference publication: EUROPEAN HEART JOURNAL. 2019;40:3024
- Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2019;28:333-334
- Conference publication: EUROPEAN HEART JOURNAL. 2018;39:757
- Conference publication: CIRCULATION. 2018;138
- Conference publication: CIRCULATION. 2018;138
- Conference publication: ANNALS OF NUTRITION AND METABOLISM. 2017;71:322-323
- Conference publication: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2017;37
- Corrigendum: PLOS GENETICS. 2016;12(6):e1006166
- Conference publication: CIRCULATION. 2016;134
- Conference publication: CIRCULATION. 2016;134
- Conference publication: THE FASEB JOURNAL. 2015;29
- Conference publication: MENOPAUSE. 2015;22(12):1373
- Review: ENVIRONMENTAL HEALTH PERSPECTIVES. 2014;122(9):896-905
- Conference publication: ATHEROSCLEROSIS. 2014;235(2):E48-E49
- Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2014;103:s44
- Letter: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2014;173(3):560
- Conference publication: EUROPEAN HEART JOURNAL. 2014;35:436
- Conference publication: EUROPEAN HEART JOURNAL. 2014;35:205
- Conference publication: EUROPEAN HEART JOURNAL. 2014;35:370-371
- Conference publication: EUROPEAN HEART JOURNAL. 2013;34:306
- Published conference paper: BRITISH JOURNAL OF SURGERY. 2012;99(5):647-653
- Conference publication: EUROPEAN HEART JOURNAL. 2012;33:810
- Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2012;93:S7
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:652-653
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:540
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:539
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:254-255
- Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2011;9:397
- Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183:652-653
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:536
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2010;11(2):13
- Conference publication: EUROPEAN HEART JOURNAL. 2010;31:746
- Conference publication: EUROPEAN HEART JOURNAL. 2010;31:537
- Meeting abstract: EPIDEMIOLOGY. 2009;20(6):S156-S157
- Meeting abstract: ATHEROSCLEROSIS. 2009;207(1):E4
- Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2009;10(2)
- Conference publication: CIRCULATION. 2009;120(18):S589
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Forskningsbidrag
- Swedish Research Council1 January 2024 - 31 December 2026
- Swedish Research Council1 January 2023 - 31 December 2025
- Swedish Research Council1 January 2020 - 31 December 2022
- Swedish Heart-Lung Foundation1 January 2019 - 31 December 2021
- Swedish Research Council for Health Working Life and Welfare1 January 2018 - 31 December 2019
- Swedish Research Council1 January 2017 - 31 December 2018
- Familial factors and cardiovascular disease-genetic-epidemiological studies and molecular mechanismsSwedish Research Council1 January 2014 - 31 December 2016
Anställningar
- Lektor, Institutet för miljömedicin, Karolinska Institutet, 2019-
Examina och utbildning
- Docent, Epidemiologi, Karolinska Institutet, 2012
- MEDICINE DOKTORSEXAMEN, Institutet för miljömedicin, Karolinska Institutet, 2005
- Medicine Magisterexamen, Karolinska Institutet, 1999
- Medicine Kandidatexamen, Karolinska Institutet, 1997