Juleen Zierath

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Forskningsbeskrivning

Forskargruppsledare för gruppen Integrativ fysiologi vid institutionen för fysiologi och farmakologi och vid institutionen för molekylär medicin och kirurgi.

Artiklar

Journal article: JOURNAL OF SPORT AND HEALTH SCIENCE. 2024;:100980
Unlocking the secrets of exercise: A pathway to enhanced insulin sensitivity and skeletal muscle health in type 2 diabetes.
Zierath JR; Brady AJ; Macgregor KA; de Zevallos JO; Stocks B
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2024;158:155939
Diacylglycerol kinase delta overexpression improves glucose clearance and protects against the development of obesity
Jollet M; Tramontana F; Jiang LQ; Borg ML; Savikj M; Kuefner MS; Massart J; Barbosa TDC; Manneras-Holm L; Checa A; Pillon NJ; Chibalin AV; Bjornholm M; Zierath JR
Article: MOLECULAR METABOLISM. 2024;86:101968
Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism
Nomura K; Kinoshita S; Mizusaki N; Senga Y; Sasaki T; Kitamura T; Sakaue H; Emi A; Hosooka T; Matsuo M; Okamura H; Amo T; Wolf AM; Kamimura N; Ohta S; Itoh T; Hayashi Y; Kiyonari H; Krook A; Zierath JR; Kasuga M; Ogawa W
Article: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. 2024;15(4):1335-1347
Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6
Guimaraes DSPSF; Barrios NMF; de Oliveira AG; Rizo-Roca D; Jollet M; Smith JAB; Araujo TR; da Cruz MV; Marconato E; Hirabara SM; Vieira AS; Krook A; Zierath JR; Silveira LR
Article: NATURE METABOLISM. 2024;6(7):1329-1346
Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health
Lecoutre S; Maqdasy S; Rizo-Roca D; Renzi G; Vlassakev I; Alaeddine LM; Higos R; Jalkanen J; Zhong J; Zareifi DS; Frendo-Cumbo S; Massier L; Hodek O; Juvany M; Moritz T; de Castro Barbosa T; Omar-Hmeadi M; Lopez-Yus M; Merabtene F; Abatan JB; Marcelin G; El Hachem E-J; Rouault C; Bergo MO; Petrus P; Zierath JR; Clement K; Krook A; Mejhert N; Ryden M
Article: NATURE METABOLISM. 2024;6(6):1024-1035
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity
Jiang S; Yuan T; Rosenberger FA; Mourier A; Dragano NRV; Kremer LS; Rubalcava-Gracia D; Hansen FM; Borg M; Mennuni M; Filograna R; Alsina D; Misic J; Koolmeister C; Papadea P; de Angelis MH; Ren L; Andersson O; Unger A; Bergbrede T; Di Lucrezia R; Wibom R; Zierath JR; Krook A; Giavalisco P; Mann M; Larsson N-G
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2024;155:155834
Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice
Pendergrast LA; Ashcroft SP; Ehrlich AM; Treebak JT; Krook A; Dollet L; Zierath JR
Article: CELL REPORTS MEDICINE. 2024;5(1):101348
Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M
Dollet L; Lundell LS; Chibalin AV; Pendergrast LA; Pillon NJ; Lansbury EL; Elmastas M; Frendo-Cumbo S; Jalkanen J; Barbosa TDC; Cervone DT; Caidahl K; Dmytriyeva O; Deshmukh AS; Barres R; Ryden M; Wallberg-Henriksson H; Zierath JR; Krook A
Article: CELL METABOLISM. 2023;35(10):1722-1735.e5
Seasonal light hours modulate peripheral clocks and energy metabolism in mice
Small L; Lundell LS; Iversen J; Ehrlich AM; Dall M; Basse AL; Dalbram E; Hansen AN; Treebak JT; Barres R; Zierath JR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(14):e2220102120
metabolism in a tissue-specific manner
Basse AL; Nielsen KN; Karavaeva I; Ingerslev LR; Ma T; Havelund JF; Nielsen TS; Frost M; Peics J; Dalbram E; Dall M; Zierath JR; Barres R; Faergeman NJ; Treebak JT; Gerhart-Hines Z
Article: STAR PROTOCOLS. 2023;4(1):101985
Protocol to assess arteriovenous differences across the liver and hindlimb muscles in mice following treadmill exercise
Ashcroft SP; Jepsen SL; Ehrlich AM; Treebak JT; Holst JJ; Zierath JR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(8):e2218510120
Time of day determines postexercise metabolism in mouse adipose tissue
Pendergrast LA; Lundell LS; Ehrlich AM; Ashcroft SP; Schoenke M; Basse AL; Krook A; Treebak JT; Dollet L; Zierath JR
Article: GEROSCIENCE. 2023;45(1):569-589
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary
Erickson ML; Allen JM; Beavers DP; Collins LM; Davidson KW; Erickson KI; Esser KA; Hesselink MKC; Moreau KL; Laber EB; Peterson CA; Peterson CM; Reusch JE; Thyfault JP; Youngstedt SD; Zierath JR; Goodpaster BH; LeBrasseur NK; Buford TW; Sparks LM
Article: LIFE SCIENCE ALLIANCE. 2023;6(1):e202201598
Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers
Pillon NJ; Puig LS; Altintas A; Kamble PG; Casani-Galdon S; Gabriel BM; Barres R; Conesa A; Chibalin AV; Naslund E; Krook A; Zierath JR
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2022;135:155268
Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients - A randomized crossover trial
Savikj M; Stocks B; Sato S; Caidahl K; Krook A; Deshmukh AS; Zierath JR; Wallberg-Henriksson H
Article: SCIENCE ADVANCES. 2022;8(36):eabo3192
Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes
Pillon NJ; Smith JAB; Alm PS; Chibalin AV; Alhusen J; Arner E; Carninci P; Fritz T; Otten J; Olsson T; de ten Ryen SVD; Deldicque L; Caidahl K; Wallberg-Henriksson H; Krook A; Zierath JR
Article: NATURE GENETICS. 2022;54(9):1332-1344
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Wang Z; Emmerich A; Pillon NJ; Moore T; Hemerich D; Cornelis MC; Mazzaferro E; Broos S; Ahluwalia TS; Bartz TM; Bentley AR; Bielak LF; Chong M; Chu AY; Berry D; Dorajoo R; Dueker ND; Kasbohm E; Feenstra B; Feitosa MF; Gieger C; Graff M; Hall LM; Haller T; Hartwig FP; Hillis DA; Huikari V; Heard-Costa N; Holzapfel C; Jackson AU; Johansson A; Jorgensen AM; Kaakinen MA; Karlsson R; Kerr KF; Kim B; Koolhaas CM; Kutalik Z; Lagou V; Lind PA; Lorentzon M; Lyytikainen L-P; Mangino M; Metzendorf C; Monroe KR; Pacolet A; Perusse L; Pool R; Richmond RC; Rivera NV; Robiou-Du-Pont S; Schraut KE; Schulz C-A; Stringham HM; Tanaka T; Teumer A; Turman C; Van der Most PJ; Vanmunster M; Van Rooij FJA; Van Vliet-Ostaptchouk JV; Zhang X; Zhao J-H; Zhao W; Balkhiyarova Z; Balslev-Harder MN; Baumeister SE; Beilby J; Blangero J; Boomsma DI; Brage S; Braund PS; Brody JA; Bruinenberg M; Ekelund U; Liu C-T; Cole JW; Collins FS; Cupples LA; Esko T; Enroth S; Faul JD; Fernandez-Rhodes L; Fohner AE; Franco OH; Galesloot TE; Gordon SD; Grarup N; Hartman CA; Heiss G; Hui J; Illig T; Jago R; James A; Joshi PK; Jung T; Kahonen M; Kilpelainen TO; Koh W-P; Kolcic I; Kraft PP; Kuusisto J; Launer LJ; Li A; Linneberg A; Luan J; Vidal PM; Medland SE; Milaneschi Y; Moscati A; Musk B; Nelson CP; Nolte IM; Pedersen NL; Peters A; Peyser PA; Power C; Raitakari OT; Reedik M; Reiner AP; Ridker PM; Rudan I; Ryan K; Sarzynski MA; Scott LJ; Scott RA; Sidney S; Siggeirsdottir K; Smith AV; Smith JA; Sonestedt E; Strom M; Tai ES; Teo KK; Thorand B; Toenjes A; Tremblay A; Uitterlinden AG; Vangipurapu J; Van Schoor N; Volker U; Willemsen G; Williams K; Wong Q; Xu H; Young KL; Yuan JM; Zillikens MC; Zonderman AB; Ameur A; Bandinelli S; Bis JC; Boehnke M; Bouchard C; Chasman DI; Smith GD; De Geus EJC; Deldicque L; Dorr M; Evans MK; Ferrucci L; Fornage M; Fox C; Garland TJ; Gudnason V; Gyllensten U; Hansen T; Hayward C; Horta BL; Hypponen E; Jarvelin M-R; Johnson WC; Kardia SLR; Kiemeney LA; Laakso M; Langenberg C; Lehtimaki T; Le Marchand L; Magnusson PKE; Martin NG; Melbye M; Metspalu A; Meyre D; North KE; Ohlsson C; Oldehinkel AJ; Orho-Melander M; Pare G; Park T; Pedersen O; Penninx BWJH; Pers TH; Polasek O; Prokopenko I; Rotimi CN; Samani NJ; Sim X; Snieder H; Sorensen TIA; Spector TD; Timpson NJ; Van Dam RM; Van der Velde N; Van Duijn CM; Vollenweider P; Volzke H; Voortman T; Waeber G; Wareham NJ; Weir DR; Wichmann H-E; Wilson JF; Hevener AL; Krook A; Zierath JR; Thomis MAI; Loos RJF; Den Hoed M
Article: DIABETES. 2022;71(4):624-636
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Dollet L; Kuefner M; Caria E; Rizo-Roca D; Pendergrast L; Abdelmoez AM; Karlsson HKR; Bjornholm M; Dalbram E; Treebak JT; Harada J; Naslund E; Ryden M; Zierath JR; Pillon NJ; Krook A
Article: MOLECULAR & CELLULAR PROTEOMICS. 2022;21(3):100207
Integrated Liver and Plasma Proteomics in Obese Mice Reveals Complex Metabolic Regulation
Stocks B; Gonzalez-Franquesa A; Borg ML; Bjornholm M; Niu L; Zierath JR; Deshmukh AS
Article: MOLECULAR METABOLISM. 2022;57:101440
Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice
Small L; Ehrlich A; Iversen J; Ashcroft SP; Trost K; Moritz T; Hartmann B; Holst JJ; Treebak JT; Zierath JR; Barres R
Article: NATURE METABOLISM. 2022;4(2):190-202
Impaired phosphocreatine metabolism in white adipocytes promotes inflammation
Maqdasy S; Lecoutre S; Renzi G; Frendo-Cumbo S; Rizo-Roca D; Moritz T; Juvany M; Hodek O; Gao H; Couchet M; Witting M; Kerr A; Bergo MO; Choudhury RP; Aouadi M; Zierath JR; Krook A; Mejhert N; Ryden M
Article: CELL METABOLISM. 2022;34(2):329-345.e8
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis
Sato S; Dyar KA; Treebak JT; Jepsen SL; Ehrlich AM; Ashcroft SP; Trost K; Kunzke T; Prade VM; Small L; Basse AL; Schonke M; Chen S; Samad M; Baldi P; Barres R; Walch A; Moritz T; Holst JJ; Lutter D; Zierath JR; Sassone-Corsi P
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2022;54(2):353-368
Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine
Kanaley JA; Colberg SR; Corcoran MH; Malin SK; Rodriguez NR; Crespo CJ; Kirwan JP; Zierath JR
Article: MOLECULAR METABOLISM. 2021;53:101290
Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health
Williams K; Carrasquilla GD; Ingerslev LR; Hochreuter MY; Hansson S; Pillon NJ; Donkin I; Versteyhe S; Zierath JR; Kilpelainen TO; Barres R
Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2021;321(5):C770-C778
Discovery of thymosin β4 as a human exerkine and growth factor
Gonzalez-Franquesa A; Stocks B; Borg ML; Kuefner M; Dalbram E; Nielsen TS; Agrawal A; Pankratova S; Chibalin AV; Karlsson HKR; Gheibi S; Bjornholm M; Jorgensen NR; Clemmensen C; Hostrup M; Treebak JT; Krook A; Zierath JR; Deshmukh AS
Article: SCIENCE ADVANCES. 2021;7(43):eabi9654
Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle
Gabriel BM; Smith JAB; Sardon-Puig L; Zhang X; Basse AL; Laker RC; Gao H; Liu Z; Dollet L; Treebak JT; Zorzano A; Huo Z; Ryden M; Lanner JT; Esser KA; Barres R; Pillon NJ; Krook A; Zierath JR
Article: NATURE COMMUNICATIONS. 2021;12(1):5948
Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism
Massart J; Sjogren RJO; Egan B; Garde C; Lindgren M; Gu W; Ferreira DMS; Katayama M; Ruas JL; Barres R; O'Gorman DJ; Zierath JR; Krook A
Article: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. 2021;12(5):1232-1248
Modified UCN2 peptide treatment improves skeletal muscle mass and function in mouse models of obesity-induced insulin resistance
Borg ML; Massart J; De Castro Barbosa T; Archilla-Ortega A; Smith JAB; Lanner JT; Alsina-Fernandez J; Yaden B; Culver AE; Karlsson HKR; Brozinick JT; Zierath JR
Article: DIABETOLOGIA. 2021;64(9):2077-2091
Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes
Sjogren RJO; Rizo-Roca D; Chibalin AV; Chorell E; Furrer R; Katayama S; Harada J; Karlsson HKR; Handschin C; Moritz T; Krook A; Naslund E; Zierath JR
Article: PROTEOMES. 2021;9(3):37
Insulin and 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome
Gonzalez-Franquesa A; Peijs L; Cervone DT; Kocana C; Zierath JR; Deshmukh AS
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2021;321(2):E203-E216
Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity
Smith JAB; Savikj M; Sethi P; Platt S; Gabriel BM; Hawley JA; Dunstan D; Krook A; Zierath JR; Naslund E
Article: CELL REPORTS. 2021;35(8):109180
Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity
Gonzalez-Franquesa A; Stocks B; Chubanava S; Hattel HB; Moreno-Justicia R; Peijs L; Treebak JT; Zierath JR; Deshmukh AS
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2021;118:154726
Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study
Karlsson HKR; Kasahara A; Ikeda M; Chibalin AV; Harada J; Ryden M; Krook A; Kato M; Kubota K; Zierath JR
Article: FRONTIERS IN PHYSIOLOGY. 2021;12:619447
The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle
Maasar M-F; Turner DC; Gorski PP; Seaborne RA; Strauss JA; Shepherd SO; Cocks M; Pillon NJ; Zierath JR; Hulton AT; Drust B; Sharples AP
Article: JOURNAL OF PHYSIOLOGY. 2020;598(24):5739-5752
Contraction influencesPer2gene expression in skeletal muscle through a calcium-dependent pathway
Small L; Altintas A; Laker RC; Ehrlich A; Pattamaprapanont P; Villarroel J; Pillon NJ; Zierath JR; Barres R
Article: CELL METABOLISM. 2020;32(5):844-859.e5
A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
Batista TM; Jayavelu AK; Albrechtsen NJW; Iovino S; Lebastchi J; Pan H; Dreyfuss JM; Krook A; Zierath JR; Mann M; Kahn CR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(38):23932-23941
Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise
Brandao BB; Madsen S; Rabiee A; Oliverio M; Ruiz GP; Ferrucci DL; Branquinho JL; Razolli D; Pinto S; Nielsen TS; Festuccia WT; Martins AS; Guerra BA; Knittel TL; Sogaard D; Larsen S; Helge JW; Brandauer J; Velloso LA; Emanuelli B; Kornfeld J-W; Kahn CR; Vienberg SG; Zierath JR; Treebak JT; Mori MA
Article: NATURE COMMUNICATIONS. 2020;11(1):4643
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
Lundell LS; Parr EB; Devlin BL; Ingerslev LR; Altintas A; Sato S; Sassone-Corsi P; Barres R; Zierath JR; Hawley JA
Article: EPIGENOMICS. 2020;12(8):701-713
Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development
Altintas A; Laker RC; Garde C; Barres R; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2020;318(3):C615-C626
Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism
Abdelmoez AM; Puig LS; Smith JAB; Gabriel BM; Savikj M; Dollet L; Chibalin AV; Krook A; Zierath JR; Pillon NJ
Article: NATURE COMMUNICATIONS. 2020;11(1):470
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
Pillon NJ; Gabriel BM; Dollet L; Smith JAB; Puig LS; Botella J; Bishop DJ; Krook A; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2020;318(1):E1-E10
Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression
Puig LS; Pillon NJ; Naslund E; Krook A; Zierath JR
Article: HEPATOLOGY RESEARCH. 2019;49(12):1451-1465
Identification of two microRNA nodes as potential cooperative modulators of liver metabolism
Hochreuter MY; Altintas A; Garde C; Emanuelli B; Kahn CR; Zierath JR; Vienberg S; Barres R
Article: THE FASEB JOURNAL. 2019;33(9):10551-10562
Secreted protein acidic and rich in cysteine (SPARC) improves glucose tolerance via AMP-activated protein kinase activation
Aoi W; Hirano N; Lassiter DG; Bjornholm M; Chibalin AV; Sakuma K; Tanimura Y; Mizushima K; Takagi T; Naito Y; Zierath JR; Krook A
Article: CELL METABOLISM. 2019;30(1):92-110.e4
Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis
Sato S; Basse AL; Schonke M; Chen S; Samad M; Altintas A; Laker RC; Dalbram E; Barres R; Baldi P; Treebak JT; Zierath JR; Sassone-Corsi P
Article: DIABETES. 2019;68(7):1403-1414
Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice
Borg ML; Massart J; Schoenke M; Barbosa TDC; Guo L; Wade M; Alsina-Fernandez J; Miles R; Ryan A; Bauer S; Coskun T; O'Farrell E; Niemeier EM; Chibalin AV; Krook A; Karlsson HK; Brozinick JT; Zierath JR
Article: THE FASEB JOURNAL. 2019;33(5):6269-6280
Paternal high-fat diet transgenerationally impacts hepatic immunometabolism
Barbosa TDC; Alm PS; Krook A; Barres R; Zierath JR
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2019;126(4):993-1005
Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action
Dalbram E; Basse AL; Zierath JR; Treebak JT
Article: JOURNAL OF NUTRITION AND METABOLISM. 2019;2019:1840374-8
Changes in Vitamin D Status in Overweight Middle-Aged Adults with or without Impaired Glucose Metabolism in Two Consecutive Nordic Summers
Lundstrom P; Caidahl K; Eriksson MJ; Fritz T; Krook A; Zierath JR; Rickenlund A
Article: DIABETES. 2019;68(3):515-526
Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle
Katayama M; Wiklander OPB; Fritz T; Caidahl K; El-Andaloussi S; Zierath JR; Krook A
Article: MOLECULAR METABOLISM. 2019;20:79-88
Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle
Lundell LS; Massart J; Altintas A; Krook A; Zierath JR
Article: DIABETOLOGIA. 2019;62(2):233-237
Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial
Savikj M; Gabriel BM; Alm PS; Smith J; Caidahl K; Bjoernholm M; Fritz T; Krook A; Zierath JR; Wallberg-Henriksson H
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2019;316(2):E178-E185
Short-term low-calorie diet remodels skeletal muscle lipid profile and metabolic gene expression in obese adults
Nylen C; Lundell LS; Massart J; Zierath JR; Naslund E
Article: MOLECULAR METABOLISM. 2018;16:12-23
AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle
Lassiter DG; Sjogren RJO; Gabriel BM; Krook A; Zierath JR
Article: JOURNAL OF OBESITY. 2018;2018:7461903-8
Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus
Mashili FL; Ramaiya K; Lutale J; Njelekela M; Francis F; Zierath J; Krook A
Article: SCIENCE ADVANCES. 2018;4(8):eaar8590
Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans
Cedernaes J; Schonke M; Westholm JO; Mi J; Chibalin A; Voisin S; Osler M; Vogel H; Hornaeus K; Dickson SL; Lind SB; Bergquist J; Schioth HB; Zierath JR; Benedict C
Article: JOURNAL OF LIPID RESEARCH. 2018;59(7):1148-1163
Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells
Pillon NJ; Frendo-Cumbo S; Jacobson MR; Liu Z; Milligan PL; Bui HH; Zierath JR; Bilan PJ; Brozinick JT; Klip A
Article: JOURNAL OF LIPID RESEARCH. 2018;59(7):1276-1282
Effects of high-fat diet and AMP-activated protein kinase modulation on the regulation of whole-body lipid metabolism
Schoenke M; Massart J; Zierath JR
Article: ACTA PHYSIOLOGICA. 2018;223(3):e13051
Protein translation, proteolysis and autophagy in human skeletal muscle atrophy after spinal cord injury
Lundell LS; Savikj M; Kostovski E; Iversen PO; Zierath JR; Krook A; Chibalin AV; Widegren U
Article: PHYSIOLOGICAL REPORTS. 2018;6(12):e13739
Retained differentiation capacity of human skeletal muscle satellite cells from spinal cord-injured individuals
Savikj M; Ruby MA; Kostovski E; Iversen PO; Zierath JR; Krook A; Widegren U
Article: PROTEOMICS. 2018;18(5-6):e1700375
Proteomics Analysis of Skeletal Muscle from Leptin-Deficient ob/ob Mice Reveals Adaptive Remodeling of Metabolic Characteristics and Fiber Type Composition
Schonke M; Bjornholm M; Chibalin AV; Zierath JR; Deshmukh AS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(9):E2048-E2057
The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals
Younis S; Schonke M; Massart J; Hjortebjerg R; Sundstrom E; Gustafson U; Bjornholm M; Krook A; Frystyk J; Zierath JR; Andersson L
Article: DIABETOLOGIA. 2018;61(2):424-432
FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle
Lassiter DG; Nylen C; Sjogren RJO; Chibalin AV; Wallberg-Henriksson H; Naslund E; Krook A; Zierath JR
Article: JOURNAL OF LIPID RESEARCH. 2018;59(2):273-282
Diacylglycerol kinase. deficiency alters inflammation markers in adipose tissue in response to a high-fat diet
Nascimento EBM; Manneras-Holm L; Chibalin AV; Bjornholm M; Zierath JR
Article: FRONTIERS IN PHYSIOLOGY. 2018;9:1198
Skeletal Muscle Insulin Sensitivity Show Circadian Rhythmicity Which Is Independent of Exercise Training Status
Basse AL; Dalbram E; Larsson L; Gerhart-Hines Z; Zierath JR; Treebak JT
Article: JOURNAL OF LIPID RESEARCH. 2017;58(12):2324-2333
DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism
Benziane B; Borg ML; Tom RZ; Riedl I; Massart J; Bjornholm M; Gilbert M; Chibalin AV; Zierath JR
Article: SCIENTIFIC REPORTS. 2017;7(1):15134
Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans
Laker RC; Garde C; Camera DM; Smiles WJ; Zierath JR; Hawley JA; Barres R
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2017;313(4):E483-E491
Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle
Ruby MA; Riedl I; Massart J; Ahlin M; Zierath JR
Article: JOURNAL OF PHYSIOLOGY. 2017;595(14):4611-4630
Early vertebrate origin and diversification of small transmembrane regulators of cellular ion transport
Pirkmajer S; Kirchner H; Lundell LS; Zelenin PV; Zierath JR; Makarova KS; Wolf YI; Chibalin AV
Article: MOLECULAR METABOLISM. 2017;6(7):621-630
Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle
Alm PS; Barbosa TDC; Barres R; Krook A; Zierath JR
Article: DIABETES. 2017;66(7):1807-1818
Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle
Massart J; Sjogren RJO; Lundell LS; Mudry JM; Franck N; O'Gorman DJ; Egan B; Zierath JR; Krook A
Article: JOURNAL OF LIPID RESEARCH. 2017;58(5):907-915
Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice
Manneras-Holm L; Schonke M; Brozinick JT; Vetterli L; Bui H-H; Sanders P; Nascimento EBM; Bjornholm M; Chibalin AV; Zierath JR
Article: DIABETES. 2017;66(3):598-612
Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK
Kjobsted R; Munk-Hansen N; Birk JB; Foretz M; Viollet B; Bjornholm M; Zierath JR; Treebak JT; Wojtaszewski JFP
Article: DIABETES. 2017;66(3):651-662
Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle
Mudry JM; Lassiter DG; Nylen C; Garcia-Calzon S; Naslund E; Krook A; Zierath JR
Article: CELL REPORTS. 2017;18(3):636-646
Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance
Ruby MA; Massart J; Hunerdosse DM; Schonke M; Correia JC; Louie SM; Ruas JL; Naslund E; Nomura DK; Zierath JR
Article: PLOS MEDICINE. 2016;13(11):e1002179
Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
Lotta LA; Scott RA; Sharp SJ; Burgess S; Luan J; Tillin T; Schmidt AF; Imamura F; Stewart ID; Perry JRB; Marney L; Koulman A; Karoly ED; Forouhi NG; Sjogren RJO; Naslund E; Zierath JR; Krook A; Savage DB; Griffin JL; Chaturvedi N; Hingorani AD; Khaw K-T; Barroso I; McCarthy MI; O'Rahilly S; Wareham NJ; Langenberg C
Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2016;32(7):754-761
Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes
Mudry JM; Alm PS; Erhardt S; Goiny M; Fritz T; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2016;310(6):E461-E472
AMPKγ3 is dispensable for skeletal muscle hypertrophy induced by functional overload
Riedl I; Osler ME; Bjornholm M; Egan B; Nader GA; Chibalin AV; Zierath JR
Article: MOLECULAR METABOLISM. 2016;5(3):171-183
Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients
Kirchner H; Sinha I; Gao H; Ruby MA; Schonke M; Lindvall JM; Barres R; Krook A; Naslund E; Dahlman-Wright K; Zierath JR
Article: MOLECULAR METABOLISM. 2016;5(3):184-197
High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring
Barbosa TDC; Ingerslev LR; Alm PS; Versteyhe S; Massart J; Rasmussen M; Donkin I; Sjogren R; Mudry JM; Vetterli L; Gupta S; Krook A; Zierath JR; Barres R
Article: CELL METABOLISM. 2016;23(2):369-378
Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans
Donkin I; Versteyhe S; Ingerslev LR; Qian K; Mechta M; Nordkap L; Mortensen B; Appel EVR; Jorgensen N; Kristiansen VB; Hansen T; Workman CT; Zierath JR; Barres R
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2016;310(1):E51-E60
Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics
Jiang LQ; Barbosa TDC; Massart J; Deshmukh AS; Lofgren L; Duque-Guimaraes DE; Ozilgen A; Osler ME; Chibalin AV; Zierath JR
Article: MOLECULAR METABOLISM. 2015;4(12):891-902
Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism
Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martinez-Redondo V; Agudelo LZ; Sinha I; Meierhofer D; Ribeiro V; Bjornholm M; Sauer S; Dahlman-Wright K; Zierath JR; Groen AK; Ruas JL
Article: PHYSIOLOGICAL REPORTS. 2015;3(11):e12622
MicroRNA-208b progressively declines after spinal cord injury in humans and is inversely related to myostatin expression.
Boon H; Sjögren RJO; Massart J; Egan B; Kostovski E; Iversen PO; Hjeltnes N; Chibalin AV; Widegren U; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2015;309(7):E679-E690
Skeletal muscle AMP-activated protein kinase γ1^H151R overexpression enhances whole body energy homeostasis and insulin sensitivity
Schonke M; Myers MGJ; Zierath JR; Bjornholm M
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2015;119(6):643-655
Effects of sleeping with reduced carbohydrate availability on acute training responses
Lane SC; Camera DM; Lassiter DG; Areta JL; Bird SR; Yeo WK; Jeacocke NA; Krook A; Zierath JR; Burke LM; Hawley JA
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2015;100(9):E1255-E1261
Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men
Cedernaes J; Osler ME; Voisin S; Broman J-E; Vogel H; Dickson SL; Zierath JR; Schioth HB; Benedict C
Article: DIABETES AND VASCULAR DISEASE RESEARCH. 2015;12(5):315-324
Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance
Ring M; Eriksson MJ; Fritz T; Nyberg G; Ostenson CG; Krook A; Zierath JR; Caidahl K
Article: DIABETES. 2015;64(6):2042-2055
Prior AICAR Stimulation Increases Insulin Sensitivity in Mouse Skeletal Muscle in an AMPK-Dependent Manner
Kjobsted R; Treebak JT; Fentz J; Lantier L; Viollet B; Birk JB; Schjerling P; Bjornholm M; Zierath JR; Wojtaszewski JFP
Article: DIABETES CARE. 2015;38(6):1154-1160
Changes in Gene Expression in Responders and Nonresponders to a Low-Intensity Walking Intervention
Osler ME; Fritz T; Caidahl K; Krook A; Zierath JR; Wallberg-Henriksson H
Article: PHYSIOLOGICAL REPORTS. 2015;3(4):e12372
mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance.
Mannerås-Holm L; Kirchner H; Björnholm M; Chibalin AV; Zierath JR
Article: PHYSIOLOGICAL REPORTS. 2015;3(3):e12314
Association of the ACTN3 R577X polymorphism with glucose tolerance and gene expression of sarcomeric proteins in human skeletal muscle.
Riedl I; Osler ME; Benziane B; Chibalin AV; Zierath JR
Article: PHYSIOLOGICAL GENOMICS. 2015;47(3):45-57
Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells
Sjogren RJO; Egan B; Katayama M; Zierath JR; Krook A
Article: DIABETES. 2015;64(2):360-369
Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation
Pirkmajer S; Kulkarni SS; Tom RZ; Ross FA; Hawley SA; Hardie DG; Zierath JR; Chibalin AV
Article: CELL METABOLISM. 2015;21(1):138-149
Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes
Multhaup ML; Seldin MM; Jaffe AE; Lei X; Kirchner H; Mondal P; Li Y; Rodriguez V; Drong A; Hussain M; Lindgren C; McCarthy M; Naslund E; Zierath JR; Wong GW; Feinberg AP
Article: HYPERTENSION RESEARCH. 2014;37(11):999-1007
Arterial stiffness estimation in healthy subjects: a validation of oscillometric (Arteriograph) and tonometric (SphygmoCor) techniques
Ring M; Eriksson MJ; Zierath JR; Caidahl K
Article: CELL. 2014;159(1):33-45
Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression
Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Article: NATURE. 2014;512(7513):190-193
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
Moltke I; Grarup N; Jorgensen ME; Bjerregaard P; Treebak JT; Fumagalli M; Korneliussen TS; Andersen MA; Nielsen TS; Krarup NT; Gjesing AP; Zierath JR; Linneberg A; Wu X; Sun G; Jin X; Al-Aama J; Wang J; Borch-Johnsen K; Pedersen O; Nielsen R; Albrechtsen A; Hansen T
Article: SURGERY FOR OBESITY AND RELATED DISEASES. 2014;10(4):671-678
Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass
Kirchner H; Nylen C; Laber S; Barres R; Yan J; Krook A; Zierath JR; Naslund E
Article: BMC RESEARCH NOTES. 2014;7:391
A simple and rapid method to characterize lipid fate in skeletal muscle.
Massart J; Zierath JR; Chibalin AV
Article: DIABETES. 2014;63(5):1560-1571
Effects of AMPK Activation on Insulin Sensitivity and Metabolism in Leptin-Deficient ob/ob Mice
Tom RZ; Garcia-Roves PM; Sjogren RJO; Jiang LQ; Holmstrom MH; Deshmukh AS; Vieira E; Chibalin AV; Bjornholm M; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2013;305(11):E1408-E1414
Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle
Nascimento EBM; Osler ME; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2013;305(11):E1359-E1366
Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7
Jiang LQ; Franck N; Egan B; Sjogren RJO; Katayama M; Duque-Guimaraes D; Arner P; Zierath JR; Krook A
Article: JOURNAL OF PHYSIOLOGY. 2013;591(20):5207-5220
AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle
Brandauer J; Vienberg SG; Andersen MA; Ringholm S; Risis S; Larsen PS; Kristensen JM; Frosig C; Leick L; Fentz J; Jorgensen S; Kiens B; Wojtaszewski JFP; Richter EA; Zierath JR; Goodyear LJ; Pilegaard H; Treebak JT
Article: ENDOCRINOLOGY. 2013;154(10):3502-3514
Conventional Knockout of Tbc1d1 in Mice Impairs Insulin- and AICAR-Stimulated Glucose Uptake in Skeletal Muscle
Dokas J; Chadt A; Nolden T; Himmelbauer H; Zierath JR; Joost H-G; Al-Hasani H
Article: JOURNAL OF PHYSIOLOGY. 2013;591(18):4637-4653
Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training
Russell AP; Lamon S; Boon H; Wada S; Gueller I; Brown EL; Chibalin AV; Zierath JR; Snow RJ; Stepto N; Wadley GD; Akimoto T
Article: THE FASEB JOURNAL. 2013;27(9):3660-3671
Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet
Cansby E; Amrutkar M; Holm LM; Nerstedt A; Reyahi A; Stenfeldt E; Boren J; Carlsson P; Smith U; Zierath JR; Mahlapuu M
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2013;62(9):1258-1267
Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice
Holmstrom MH; Tom RZ; Bjornholm M; Garcia-Roves PM; Zierath JR
Article: PHYSIOLOGICAL GENOMICS. 2013;45(9):367-376
Expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight
Ka S; Markljung E; Ring H; Albert FW; Harun-Or-Rashid M; Wahlberg P; Garcia-Roves PM; Zierath JR; Denbow DM; Paabo S; Siegel PB; Andersson L; Hallbook F
Article: CELL REPORTS. 2013;3(4):1020-1027
Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation
Barres R; Kirchner H; Rasmussen M; Yan J; Kantor FR; Krook A; Naslund E; Zierath JR
Article: DIABETES. 2013;62(2):355-361
Altered Response of Skeletal Muscle to IL-6 in Type 2 Diabetic Patients
Jiang LQ; Duque-Guimaraes DE; Machado UF; Zierath JR; Krook A
Article: DIABETES. 2013;62(2):457-465
Constitutive STAT3 Phosphorylation Contributes to Skeletal Muscle Insulin Resistance in Type 2 Diabetes
Mashili F; Chibalin AV; Krook A; Zierath JR
Article: PLOS ONE. 2013;8(9):e74098
Time Course Analysis Reveals Gene-Specific Transcript and Protein Kinetics of Adaptation to Short-Term Aerobic Exercise Training in Human Skeletal Muscle
Egan B; O'Connor PL; Zierath JR; O'Gorman DJ
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2013;62(1):79-89
L-Arginine enhances glucose and lipid metabolism in rat L6 myotubes via the NO/ c-GMP pathway
Barbosa TDC; Jiang LQ; Zierath JR; Nunes MT
Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2013;29(1):25-32
Effects of Nordic walking on cardiovascular risk factors in overweight individuals with type 2 diabetes, impaired or normal glucose tolerance
Fritz T; Caidahl K; Krook A; Lundstrom P; Mashili F; Osler M; Szekeres FLM; Ostenson CG; Wandell P; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2012;303(4):E524-E533
The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism
Szekeres F; Chadt A; Tom RZ; Deshmukh AS; Chibalin AV; Bjornholm M; Al-Hasani H; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(28):23451-23463
Activation of AMP-activated Protein Kinase Stimulates Na⁺,K⁺-ATPase Activity in Skeletal Muscle Cells
Benziane B; Bjornholm M; Pirkmajer S; Austin RL; Kotova O; Viollet B; Zierath JR; Chibalin AV
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2012;302(6):E731-E739
Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes
Holmstrom MH; Iglesias-Gutierrez E; Zierath JR; Garcia-Roves PM
Article: CELL METABOLISM. 2012;15(3):405-411
Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle
Barres R; Yan J; Egan B; Treebak JT; Rasmussen M; Fritz T; Caidahl K; Krook A; O'Gorman DJ; Zierath JR
Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2012;61(2):175-185
Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus
Kulkarni SS; Salehzadeh F; Fritz T; Zierath JR; Krook A; Osler ME
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(18):2555-2561
Evidence for non-CpG methylation in mammals
Yan J; Zierath JR; Barres R
Article: DIABETIC MEDICINE. 2011;28(11):1362-1372
Effects of Nordic walking on health-related quality of life in overweight individuals with Type 2 diabetes mellitus, impaired or normal glucose tolerance
Fritz T; Caidahl K; Osler M; Oestenson CG; Zierath JR; Waendell P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(40):34567-34574
Suppression of 5′-Nucleotidase Enzymes Promotes AMP-activated Protein Kinase (AMPK) Phosphorylation and Metabolism in Human and Mouse Skeletal Muscle
Kulkarni SS; Karlsson HKR; Szekeres F; Chibalin AV; Krook A; Zierath JR
Article: DIABETOLOGIA. 2011;54(4):795-802
Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.
Hribal ML; Presta I; Procopio T; Marini MA; Stančáková A; Kuusisto J; Andreozzi F; Hammarstedt A; Jansson P-A; Grarup N; Hansen T; Walker M; Stefan N; Fritsche A; Häring HU; Pedersen O; Smith U; Laakso M; Sesti G; EUGENE2 Consortium
Article: PROTEOMICS. 2011;11(8):1413-1428
2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training
Egan B; Dowling P; O'Connor PL; Henry M; Meleady P; Zierath JR; O'Gorman DJ
Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2011;27(3):286-297
Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity
Mashili FL; Austin RL; Deshmukh AS; Fritz T; Caidahl K; Bergdahl K; Zierath JR; Chibalin AV; Moller DE; Kharitonenkov A; Krook A
Article: THROMBOSIS AND HAEMOSTASIS. 2011;105(1):122-130
Strenuous physical exercise adversely affects monocyte chemotaxis
Czepluch FS; Barres R; Caidahl K; Olieslagers S; Krook A; Rickenlund A; Zierath JR; Waltenberger J
Article: DIABETOLOGIA. 2011;54(1):157-167
Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training
Vind BF; Pehmoller C; Treebak JT; Birk JB; Hey-Mogensen M; Beck-Nielsen H; Zierath JR; Wojtaszewski JFP; Hojlund K
Article: JOURNAL OF BIOLOGICAL SYSTEMS. 2010;18(3):687-707
VALIDATION OF THE IN VITRO INCUBATION OF EXTENSOR DIGITORUM LONGUS MUSCLE FROM MICE WITH A MATHEMATICAL MODEL
Sogaard P; Harlen M; Long YC; Szekeres F; Barnes BR; Chibalin AV; Zierath JR
Article: MOLECULAR IMMUNOLOGY. 2010;47(14):2388-2396
The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells
Feng X; Yan J; Wang Y; Zierath JR; Nordenskjold M; Henter J-I; Fadeel B; Zheng C
Article: DIABETOLOGIA. 2010;53(6):1142-1150
Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)α1-specific activity and glucose transport in human skeletal muscle
Deshmukh AS; Long YC; Barbosa TDC; Karlsson HKR; Glund S; Zavadoski WJ; Gibbs EM; Koistinen HA; Wallberg-Henriksson H; Zierath JR
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2010;588(10):1779-1790
Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor. coactivator-1α mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle
Egan B; Carson BP; Garcia-Roves PM; Chibalin AV; Sarsfield FM; Barron N; McCaffrey N; Moyna NM; Zierath JR; O'Gorman DJ
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2010;109(5):943-949
Spatial Insulin Signalling in Isolated Skeletal Muscle Preparations
Sogaard P; Szekeres F; Garcia-Roves PM; Larsson D; Chibalin AV; Zierath JR
Article: CELL METABOLISM. 2010;11(3):213-219
Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
Canto C; Jiang LQ; Deshmukh AS; Mataki C; Coste A; Lagouge M; Zierath JR; Auwerx J
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2010;298(1):E8-E16
Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity
Jiang LQ; Garcia-Roves PM; Barbosa TDC; Zierath JR
Article: PLOS BIOLOGY. 2009;7(12):e1000256
ZBED6, a Novel Transcription Factor Derived from a Domesticated DNA Transposon Regulates IGF2 Expression and Muscle Growth
Markljung E; Jiang L; Jaffe JD; Mikkelsen TS; Wallerman O; Larhammar M; Zhang X; Wang L; Saenz-Vash V; Gnirke A; Lindroth AM; Barres R; Yan J; Stromberg S; De S; Ponten F; Lander ES; Carr SA; Zierath JR; Kullander K; Wadelius C; Lindblad-Toh K; Andersson G; Hjalm G; Andersson L
Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2009;297(6):C1554-C1566
AMP-activated protein kinase activator A-769662 is an inhibitor of the Na⁺-K⁺-ATPase
Benziane B; Bjornholm M; Lantier L; Viollet B; Zierath JR; Chibalin AV
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2009;297(6):E1388-E1394
Role of the AMPKγ3 isoform inhypoxia-stimulated glucose transport in glycolytic skeletal muscle
Deshmukh AS; Glund S; Tom RZ; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(44):30016-30023
Insulin-stimulated Phosphorylation of the Rab GTPase-activating Protein TBC1D1 Regulates GLUT4 Translocation
Peck GR; Chavez JA; Roach WG; Budnik BA; Lane WS; Karlsson HKR; Zierath JR; Lienhard GE
Article: DIABETOLOGIA. 2009;52(10):2182-2189
Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes
Rune A; Osler ME; Fritz T; Zierath JR
Article: CELL METABOLISM. 2009;10(3):189-198
Non-CpG Methylation of the PGC-1α Promoter through DNMT3B Controls Mitochondrial Density
Barres R; Osler ME; Yan J; Rune A; Fritz T; Caidahl K; Krook A; Zierath JR
Article: DIABETOLOGIA. 2009;52(5):891-900
Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle
Treebak JT; Frosig C; Pehmoller C; Chen S; Maarbjerg SJ; Brandt N; MacKintosh C; Zierath JR; Hardie DG; Kiens B; Richter EA; Pilegaard H; Wojtaszewski JFP
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2009;296(5):E969-E972
Hunting for the SNARK in metabolic disease
Egan B; Zierath JR
Article: CIRCULATION RESEARCH. 2009;104(8):961-968
T Cell-Mediated Inflammation in Adipose Tissue Does Not Cause Insulin Resistance in Hyperlipidemic Mice
Sultan A; Strodthoff D; Robertson A-K; Paulsson-Berne G; Fauconnier J; Parini P; Ryden M; Thierry-Mieg N; Johansson ME; Chibalin AV; Zierath JR; Arner P; Hansson GK
Article: DIABETES. 2009;58(4):847-854
Kinetics of GLUT4 Trafficking in Rat and Human Skeletal Muscle
Karlsson HKR; Chibalin AV; Koistinen HA; Yang J; Koumanov F; Wallberg-Henriksson H; Zierath JR; Holman GD
Article: ENDOCRINOLOGY. 2009;150(2):600-606
Role of Adenosine 5′-Monophosphate-Activated Protein Kinase in Interleukin-6 Release from Isolated Mouse Skeletal Muscle
Glund S; Treebak JT; Long YC; Barres R; Viollet B; Wojtaszewski JF; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(51):35724-35734
Gain-of-function R225Q Mutation in AMP-activated Protein Kinase γ3 Subunit Increases Mitochondrial Biogenesis in Glycolytic Skeletal Muscle
Garcia-Roves PM; Osler ME; Holmstrom MH; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2008;295(6):E1427-E1438
Divergent cell signaling after short-term intensified endurance training in human skeletal muscle
Benziane B; Burton TJ; Scanlan B; Galuska D; Canny BJ; Chibalin AV; Zierath JR; Stepto NK
Article: JOURNAL OF ENDOCRINOLOGY. 2008;199(2):X1
The estrogen receptor {alpha}-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms.
Lundholm L; Bryzgalova G; Gao H; Portwood N; Fält S; Berndt KD; Dicker A; Galuska D; Zierath JR; Gustafsson J-Å; Efendic S; Dahlman-Wright K; Khan A
Article: NATURE GENETICS. 2008;40(11):1354-1359
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity
Chadt A; Leicht K; Deshmukh A; Jiang LQ; Scherneck S; Bernhardt U; Dreja T; Vogel H; Schmolz K; Kluge R; Zierath JR; Hultschig C; Hoeben RC; Schuermann A; Joost H-G; Al-Hasani H
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2008;295(5):E1032-E1037
Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle
Vieira E; Nilsson EC; Nerstedt A; Ormestad M; Long YC; Garcia-Roves PM; Zierath JR; Mahlapuu M
Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2008;24(7):554-562
Globular adiponectin stimulates glucose transport in type 2 diabetic muscle
Kuoppamaa H; Skrobuk P; Sihvo M; Hiukka A; Chibalin AV; Zierath JR; Koistinen HA
Article: DIABETES. 2008;57(8):2066-2073
SiRNA-mediated reduction of inhibitor of nuclear factor-κB kinase prevents tumor necrosis factor-α-induced insulin resistance in human skeletal muscle
Austin RL; Rune A; Bouzakri K; Zierath JR; Krook A
Article: CELL METABOLISM. 2008;7(6):545-554
Glutamate is a positive autocrine signal for glucagon release
Cabrera O; Jacques-Silva MC; Speier S; Yang S-N; Kohler M; Fachado A; Vieira E; Zierath JR; Kibbey R; Berman DM; Kenyon NS; Ricordi C; Caicedo A; Berggren P-O
Article: DIABETES. 2008;57(6):1508-1516
Malonyl coenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle
Bouzakri K; Austin R; Rune A; Lassman ME; Garcia-Roves PM; Berger JP; Krook A; Chibalin AV; Zhang BB; Zierath JR
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2008;93(5):1924-1930
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.
Stancáková A; Pihlajamäki J; Kuusisto J; Stefan N; Fritsche A; Häring H; Andreozzi F; Succurro E; Sesti G; Boesgaard TW; Hansen T; Pedersen O; Jansson PA; Hammarstedt A; Smith U; Laakso M; EUGENE2 Consortium
Article: MOLECULAR ENDOCRINOLOGY. 2008;22(5):1105-1112
Role of adenosine 5′-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling
Deshmukh AS; Treebak JT; Long YC; Viollet B; Wojtaszewski JFP; Zierath JR
Article: DIABETOLOGIA. 2008;51(3):502-511
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study.
Laakso M; Zilinskaite J; Hansen T; Boesgaard TW; Vänttinen M; Stancáková A; Jansson P-A; Pellmé F; Holst JJ; Kuulasmaa T; Hribal ML; Sesti G; Stefan N; Fritsche A; Häring H; Pedersen O; Smith U; EUGENE2 Consortium
Article: CELL. 2008;132(3):375-386
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance
Chibalin AV; Leng Y; Vieira E; Krook A; Bjoernholm M; Long YC; Kotova O; Zhong Z; Sakane F; Steiler T; Nylen C; Wang J; Laakso M; Topham MK; Gilbert M; Wallberg-Henriksson H; Zierath JR
Article: EXPERT REVIEW OF ENDOCRINOLOGY AND METABOLISM. 2007;2(4):477-485
Skeletal muscle AMP kinase as a target to prevent pathogenesis of Type 2 diabetes.
Krook A; Long YC; Zierath JR
Article: DIABETES. 2007;56(6):1630-1637
Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle
Glund S; Deshmukh A; Long YC; Moller T; Koistinen HA; Caidahl K; Zierath JR; Krook A
Article: PLOS MEDICINE. 2007;4(5):e158-879
TXNIP regulates peripheral glucose metabolism in humans
Parikh H; Carlsson E; Chutkow WA; Johansson LE; Storgaard H; Poulsen P; Saxena R; Ladd C; Schulze PC; Mazzini MJ; Jensen CB; Krook A; Bjornholm M; Tornqvist H; Zierath JR; Ridderstrale M; Altshuler D; Lee RT; Vaag A; Groop LC; Mootha VK
Article: DIABETOLOGIA. 2007;50(5):1048-1057
Effect of a novel non-thiazolidinedione peroxisome proliferator-activated receptor α/γ agonist on glucose uptake
Hu X; Feng Y; Liu X; Zhao X-F; Yu J-H; Yang Y-S; Sydow-Backman M; Horling J; Zierath JR; Leng Y
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(11):7783-7789
MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-α-induced insulin resistance
Bouzakri K; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(3):1607-1614
Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression
Long YC; Glund S; Garcia-Roves PM; Zierath JR
Article: DIABETOLOGIA. 2006;49(12):2983-2992
Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes
O'Gorman DJ; Karlsson HKR; McQuaid S; Yousif O; Rahman Y; Gasparro D; Glund S; Chibalin AV; Zierath JR; Nolan JJ
Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2006;22(6):492-498
Low-intensity exercise increases sketelal muscle protein expression of PPARδ and UCP3 in type 2 diabetic patients
Fritz T; Kramer DK; Karlsson HKR; Galuska D; Engfeldt P; Zierath JR; Krook A
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2006;63(19-20):2405-2414
Specific cleavage of insulin-like growth factor-binding protein-1 by a novel protease activity
Wang J; Shafqat J; Hall K; Stahlberg M; Wivall-Helleryd I-L; Bouzakri K; Zierath JR; Brismar K; Jornvall H; Lewitt MS
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(31):21690-21697
Neuregulins mediate calcium-induced glucose transport during muscle contraction
Canto C; Chibalin AV; Barnes BR; Glund S; Suarez E; Ryder JW; Palacin M; Zierath JR; Zorzano A; Guma A
Article: CELL METABOLISM. 2006;4(1):89-96
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
Bouzakri K; Zachrisson A; Al-Khalili L; Zhang BB; Koistinen HA; Krook A; Zierath JR
Article: DIABETES. 2006;55(7):2051-2058
AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits
Treebak JT; Glund S; Deshmukh A; Klein DK; Long YC; Jensen TE; Jorgensen SB; Viollet B; Andersson L; Neumann D; Wallimann T; Richter EA; Chibalin AV; Zierath JR; Wojtaszewski JFP
Article: DIABETES. 2006;55(6):1776-1782
Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle
Deshmukh A; Coffey VG; Zhong Z; Chibalin AV; Hawley JA; Zierath JR
Article: DIABETES. 2006;55(5):1283-1288
Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients
Karlsson HKR; Ahlsen M; Zierath JR; Wallberg-Henriksson H; Koistinen HA
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(11):7244-7252
Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase γ3 R225Q transgenic versus knock-out mice
Nilsson EC; Long YC; Martinsson S; Glund S; Garcia-Roves P; Svensson LT; Andersson L; Zierath JR; Mahlapuu M
Article: DIABETES. 2006;55(3):785-791
IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients
Bouzakri K; Karlsson HKR; Vestergaard H; Madsbad S; Christiansen E; Zierath JR
Article: DIABETOLOGIA. 2006;49(3):588-597
Evidence that oestrogen receptor-α plays an important role in the regulation of glucose homeostasis in mice:: insulin sensitivity in the liver
Bryzgalova G; Gao H; Ahren B; Zierath JR; Galuska D; Steiler TL; Dahlman-Wright K; Nilsson S; Gustafsson J; Efendic S; Khan A
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2006;17(1):45-52
Differential expression of peroxisomal proliferator activated receptors α and δ in skeletal muscle in response to changes in diet and exercise
Kannisto K; Chibalin A; Glinghammar B; Zierath JR; Hamsten A; Ehrenborg E
Article: FASEB JOURNAL. 2006;19(13):190-192
Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans
Coffey VG; Zhong ZH; Shield A; Canny BJ; Chibalin AV; Zierath JR; Hawley JA
Article: DIABETES. 2005;54(12):3484-3489
Changes in exercise-induced gene expression in 5′-AMP-activated protein kinase γ3-null and γ3 R225Q transgenic mice
Barnes BR; Long YC; Steiler TL; Leng Y; Galuska D; Wojtaszewski JFP; Andersson L; Zierath JR
Article: DIABETOLOGIA. 2005;48(11):2354-2364
Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle
Long YC; Barnes BR; Mahlapuu M; Steiler TL; Martinsson S; Leng Y; Wallberg-Henriksson H; Andersson L; Zierath JR
Article: DIABETES. 2005;54(10):2939-2945
Tumor necrosis factor-α induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation
Plomgaard P; Bouzakri K; Krogh-Madsen R; Mittendorfer B; Zierath JR; Pedersen BK
Article: DIABETES. 2005;54(9):2685-2693
Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle -: Effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor α, and interleukin-6
Bach D; Naon D; Pich S; Soriano FX; Vega N; Rieusset J; Laville M; Guillet C; Boirie Y; Wallberg-Henriksson H; Manco M; Calvani M; Castagneto M; Palacín M; Mingrone G; Zierath JR; Vidal H; Zorzano A
Article: JOURNAL OF PHYSIOLOGY. 2005;567(2):379-386
Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose transport in skeletal muscle
Ryder JW; Long YC; Nilsson E; Mahlapuu M; Zierath JR
Article: DIABETES. 2005;54(6):1692-1697
Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects
Karlsson HKR; Zierath JR; Kane S; Krook A; Lienhard GE; Wallberg-Henriksson H
Article: DIABETOLOGIA. 2005;48(6):1173-1179
Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1
Al-Khalili L; Forsgren M; Kannisto K; Zierath J; Lönnqvist F; Krook A
Article: DIABETES. 2005;54(5):1459-1467
Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes -: A randomized controlled study
Karlsson HKR; Hällsten K; Björnholm M; Tsuchida H; Chibalin AV; Virtanen KA; Heinonen OJ; Lönnqvist F; Nuutila P; Zierath JR
Article: THE FASEB JOURNAL. 2005;19(7):773-779
5′-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics
Barnes BR; Glnnd S; Long YC; Hjälm G; Andersson L; Zierath JR
Article: DIABETES. 2005;54(4):1157-1163
Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor δ
Krämer DK; Al-Khalili L; Perrini S; Skogsberg J; Wretenberg P; Kannisto K; Wallberg-Henriksson H; Ehrenborg E; Zierath JR; Krook A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(37):38441-38447
The 5′-AMP-activated protein kinase γ3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle
Barnes BR; Marklund S; Steiler TL; Walter M; Hjälm G; Amarger V; Mahlapuu M; Leng Y; Johansson C; Galuska D; Lindgren K; Åbrink M; Stapleton D; Zierath JR; Andersson L
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;287(3):E553-E557
Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake
Al-Khalili L; Krook A; Zierath JR; Cartee GD
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2004;36(7):1212-1217
Sending the signal: Molecular mechanisms regulating glucose uptake
Krook A; Wallberg-Henriksson H; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;287(1):E1-E7
Branched-chain amino acids increase p70^S6k phosphorylation in human skeletal muscle after resistance exercise
Karlsson HKR; Nilsson PA; Nilsson J; Chibalin AV; Zierath JR; Blomstrand E
Article: DIABETES. 2004;53(6):1436-1444
Effects of insulin, contraction, and phorbol esters on mitogen-activated protein kinase signaling in skeletal muscle from lean and ob/ob mice
Leng Y; Steiler TL; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2004;286(6):C1410-C1416
MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways
Al-Khalili L; Chibalin AV; Yu M; Sjödin B; Nylén C; Zierath JR; Krook A
Article: REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS. 2004;5(2):111-117
Insulin signaling defects in type 2 diabetes
Leng Y; Karlsson HKR; Zierath JR
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2004;89(3):1301-1311
Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes
Storgaard H; Jensen CB; Björnholm MB; Song XM; Madsbad S; Zierath JR; Vaag AA
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;286(2):E194-E200
Expression profiling of the γ-subunit isoforms of AMP-activated protein kinase suggests a major role for γ3 in white skeletal muscle
Mahlapuu M; Johansson C; Lindgren K; Hjälm G; Barnes BR; Krook A; Zierath JR; Andersson L; Marklund S
Article: OBESITY. 2004;12(1):25-31
Insulin action on expression of novel adipose genes in healthy and type 2 diabetic subjects
Koistinen HA; Forsgren M; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 2004;53(1):21-24
Exercise-induced protein kinase C isoform-specific activation in human skeletal muscle
Perrini S; Henriksson J; Zierath JR; Widegren U
Article: ENDOCRINOLOGY. 2003;144(12):5259-5267
Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats
Steiler TL; Galuska D; Leng Y; Chibalin AV; Gilbert M; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(45):44298-44304
Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways
Ryder JW; Bassel-Duby R; Olson EN; Zierath JR
Article: DIABETOLOGIA. 2003;46(10):1324-1328
Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients
Koistinen HA; Chibalin AV; Zierath JR
Article: BEST PRACTICE AND RESEARCH: CLINICAL ENDOCRINOLOGY AND METABOLISM. 2003;17(3):385-398
The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle
Zierath JR; Kawano Y
Article: JOURNAL OF PHYSIOLOGY. 2003;550(1):305-315
Insulin signalling and resistance in patients with chronic heart failure
Kemppainen J; Tsuchida H; Stolen K; Karlsson H; Björnholm M; Heinonen OJ; Nuutila P; Krook A; Knuuti J; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(19):17190-17197
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism -: A novel regulatory mechanism altered in obesity
Bach D; Pich S; Soriano FX; Vega N; Baumgartner B; Oriola J; Daugaard JR; Lloberas J; Camps M; Zierath JR; Rabasa-Lhoret R; Wallberg-Henriksson H; Laville M; Palacín M; Vidal H; Rivera F; Brand M; Zorzano A
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2003;60(5):991-998
Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content
Al-Khalili L; Chibalin AV; Kannisto K; Zhang BB; Permert J; Holman GD; Ehrenborg E; Ding VDH; Zierath JR; Krook A
Article: DIABETES. 2003;52(5):1066-1072
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes
Koistinen HA; Galuska D; Chibalin AV; Yang J; Zierath JR; Holman GD; Wallberg-Henriksson H
Article: PANCREAS. 2003;26(2):173-177
Impaired insulin action on phosphatidylinositol 3-kinase activity and glucose transport in skeletal muscle cancer patients
Isaksson B; Strömmer L; Friess H; Büchler MW; Herrington MK; Wang F; Zierath JR; Wallberg-Henriksson H; Larsson J; Pennert J
Article: JOURNAL OF PHYSIOLOGY. 2003;546(2):327-335
Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise
Yu M; Stepto NK; Chibalin AV; Fryer LGD; Carling D; Krook A; Hawley JA; Zierath JR
Article: DIABETOLOGIA. 2002;45(12):1697-1702
Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans
Björnholm M; He AR; Attersand A; Lake S; Liu SCH; Lienhard GE; Taylor S; Arner P; Zierath JR
Article: PFLUGERS ARCHIV EUROPEAN JOURNAL OF PHYSIOLOGY. 2002;445(1):25-31
Gene expression of the p85α regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects
Tsuchida H; Björnholm M; Fernström M; Galuska D; Johansson P; Wallberg-Henriksson H; Zierath JR; Lake S; Krook A
Article: DIABETES. 2002;51(9):2703-2708
Isoform-specific regulation of 5′ AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction
Barnes BR; Ryder JW; Steiler TL; Fryer LGD; Carling D; Zierath JR
Article: DIABETOLOGIA. 2002;45(8):1128-1135
Insulin signal transduction and glucose transport in human adipocytes:: effects of obesity and low calorie diet
Björnholm M; Al-Khalili L; Dicker A; Näslund E; Rössner S; Zierath JR; Arner P
Article: DIABETOLOGIA. 2002;45(1):56-65
5-aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice
Song XM; Fiedler M; Galuska D; Ryder JW; Fernström M; Chibalin AV; Wallberg-Henriksson H; Zierath JR
Article: DIABETOLOGIA. 2001;44(12):2180-2186
5-aminoimidazole-4-carboxy-amide-1-β-D-ribofuranoside treatment ameliorates hyperglycaemia and hyperinsulinaemia but not dyslipidaemia in KKA^y-CETP mice
Fiedler M; Zierath JR; Selén G; Wallberg-Henriksson H; Liang Y; Sakariassen KS
Article: DIABETES. 2001;50(12):2770-2778
Insulin signal transduction in skeletal muscle from glucose-intolerant relatives with type 2 diabetes
Storgaard H; Song XM; Jensen CB; Madsbad S; Björnholm M; Vaag A; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2001;281(6):E1255-E1259
Evidence against high glucose as a mediator of ERK1/2 or p38 MAPK phosphorylation in rat skeletal muscle
Kawano Y; Ryder JW; Rincon J; Zierath JR; Krook A; Wallberg-Henriksson H
Article: JOURNAL OF PHYSIOLOGY. 2001;536(1):273-282
Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle
Yu M; Blomstrand E; Chibalin AV; Krook A; Zierath JR
Article: ENDOCRINOLOGY. 2001;142(8):3474-3482
Insulin- and glucose-induced phosphorylation of the Na⁺,K⁺-adenosine triphosphatase α-subunits in rat skeletal muscle
Chibalin AV; Kovalenko MV; Ryder JW; Féraille E; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 2001;50(5):1149-1157
Isomer-specific antidiabetic properties of conjugated linoleic acid - Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression
Ryder JW; Portocarrero CP; Song XM; Cui L; Yu M; Combatsiaris T; Galuska D; Bauman DE; Barbano DM; Charron MJ; Zierath JR; Houseknecht KL
Article: THE FASEB JOURNAL. 2001;15(6):958-969
Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physical activity
Tsao TS; Li J; Chang KS; Stenbit AE; Galuska D; Anderson JE; Zierath JR; McCarter RJ; Charron MJ
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2001;90(1):29-34
Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport
Yu M; Blomstrand E; Chibalin AV; Wallberg-Henriksson H; Zierath JR; Krook A
Article: AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2000;279(5):R1716-R1721
Effects of exercise on mitogen- and stress-activated kinase signal transduction in human skeletal muscle
Krook A; Widegren U; Jiang XJ; Henriksson J; Wallberg-Henriksson H; Alessi D; Zierath JR
Article: HUMAN MOLECULAR GENETICS. 2000;9(14):2149-2158
Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats
Fakhrai-Rad H; Nikoshkov A; Kamel A; Fernström M; Zierath JR; Norgren S; Luthman H; Galli J
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2000;279(1):E206-E212
Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle
Del Aguila LF; Krishnan RK; Ulbrecht JS; Farrell PA; Correll PH; Lang CH; Zierath JR; Kirwan JP
Article: DIABETES. 2000;49(4):647-654
Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients
Ryder JW; Yang J; Galuska D; Rincón J; Björnholm M; Krook A; Lund S; Pedersen O; Wallberg-Henriksson H; Zierath JR; Holman GD
Article: DIABETES. 2000;49(2):284-292
Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
Krook A; Björnholm M; Galuska D; Jiang XJ; Fahlman R; Myers MG; Wallberg-Henriksson H; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(2):1457-1462
Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle - Involvement of the mitogen- and stress-activated protein kinase 1
Ryder JW; Fahlman R; Wallberg-Henriksson H; Alessi DR; Krook A; Zierath JR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(1):38-43
Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: Differential effects on insulin-receptor substrates 1 and 2
Chibalin AV; Yu M; Ryder JW; Song XM; Galuska D; Krook A; Wallberg-Henriksson H; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1999;277(6):R1690-R1696
Muscle fiber type specificity in insulin signal transduction
Song XM; Ryder JW; Kawano Y; Chibalin AV; Krook A; Zierath JR
Article: THE FASEB JOURNAL. 1999;13(15):2246-2256
Postexercise glucose uptake and glycogen synthesis in skeletal muscle from GLUT4-deficient mice
Ryder JW; Kawano Y; Galuska D; Fahlman R; Wallberg-Henriksson H; Charron MJ; Zierath JR
Article: PFLUGERS ARCHIV EUROPEAN JOURNAL OF PHYSIOLOGY. 1999;439(1-2):130-133
Effect of the nicotine metabolite 5′-hydroxycotinine on glucose transport and glycogen synthase activity in rat skeletal muscle
Rincón J; Galuska D; Ryder JW; Kawano Y; Wallberg-Henriksson H; Gorrod JW; Zierath JR
Article: BIOCHEMICAL JOURNAL. 1999;342(Pt 2):321-328
In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle
Ryder JW; Kawano Y; Chibalin AV; Rincón J; Tsao TS; Stenbit AE; Combatsiaris T; Yang J; Holman GD; Charron MJ; Zierath JR
Article: DIABETOLOGIA. 1999;42(9):1071-1079
Changes in glucose transport and protein kinase Cβ₂ in rat skeletal muscle induced by hyperglycaemia
Kawano Y; Rincon J; Soler A; Ryder JW; Nolte LA; Zierath JR; Wallberg-Henriksson H
Article: DIABETOLOGIA. 1999;42(Suppl 1):a1-a330
35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999.
Article: DIABETOLOGIA. 1999;42(7):826-830
Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects
Hjeltnes N; Fernström M; Zierath JR; Krook A
Article: SCIENCE. 1999;284(5416):974-977
Discovery of a small molecule insulin mimetic with antidiabetic activity in mice
Zhang B; Salituro G; Szalkowski D; Li ZH; Zhang Y; Royo I; Vilella D; Díez MT; Pelaez F; Ruby C; Kendall RL; Mao XZ; Griffin P; Calaycay J; Zierath JR; Heck JV; Smith RG; Moller DE
Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 1999;19(2):135-142
Altered skeletal muscle glucose transport and blood lipid levels in habitual cigarette smokers
Rincón J; Krook A; Galuska D; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 1999;48(3):664-670
Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats
Song XM; Kawano Y; Krook A; Ryder JW; Efendic S; Roth RA; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 1999;48(2):310-320
Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.
Kim YB; Zhu JS; Zierath JR; Shen HQ; Baron AD; Kahn BB
Article: ENDOCRINOLOGY. 1998;139(12):5034-5041
Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARγ agonist) action
Zierath JR; Ryder JW; Doebber T; Woods J; Wu M; Ventre J; Li ZH; McCrary C; Berger J; Zhang B; Moller DE
Article: THE FASEB JOURNAL. 1998;12(15):1701-1712
Exercise-induced overexpression of key regulatory proteins involved in glucose uptake and metabolism in tetraplegic persons:: molecular mechanism for improved glucose homeostasis
Hjeltnes N; Galuska D; Björnholm M; Aksnes AK; Lannem A; Zierath JR; Wallberg-Henriksson H
Article: DIABETOLOGIA. 1998;41(11):1343-1354
Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocytes:: relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway
Zierath JR; Livingston JN; Thörne A; Bolinder J; Reynisdottir S; Lönnqvist F; Arner P
Article: THE FASEB JOURNAL. 1998;12(13):1379-1389
Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle
Widegren U; Jiang XJ; Krook A; Chibalin AV; Björnholm M; Tally M; Roth RA; Henriksson J; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 1998;47(9):1528-1531
Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients
Krook A; Digby J; O'Rahilly S; Zierath JR; Wallberg-Henriksson H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(33):20910-20915
Restoration of hypoxia-stimulated glucose uptake in GLUT4-deficient muscles by muscle-specific GLUT4 transgenic complementation
Zierath JR; Tsao TS; Stenbit AE; Ryder JW; Galuska D; Charron MJ
Article: DIABETES. 1998;47(8):1281-1286
Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects
Krook A; Roth RA; Jiang XJ; Zierath JR; Wallberg-Henriksson H
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1998;275(2):E351-E358
Skeletal muscle insulin resistance after trauma: insulin signaling and glucose transport
Strommer L; Permert J; Arnelo U; Koehler C; Isaksson B; Larsson J; Lundkvist I; Bjornholm M; Kawano Y; Wallberg-Henriksson H; Zierath JR
Article: MOLECULAR AND CELLULAR BIOCHEMISTRY. 1998;182(1-2):153-160
Insulin action in skeletal muscle from patients with NIDDM
Zierath JR; Krook A; Wallberg-Henriksson H
Article: MOLECULAR BIOLOGY OF THE CELL. 1998;9(5):1209-1220
Phosphatidylinositol 3-kinase-mediated endocytosis of renal Na⁺,K⁺-ATPase α subunit in response to dopamine
Chibalin AV; Zierath JR; Katz AI; Berggren PO; Bertorello AM
Article: DIABETES. 1998;47(1):1-4
Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes
Zierath JR; Frevert EU; Ryder JW; Berggren PO; Kahn BB
Article: DIABETES. 1997;46(12):2110-2114
Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats
Krook A; Kawano Y; Song XM; Efendic S; Roth RA; WallbergHenriksson H; Zierath JR
Article: DIABETES. 1997;46(12):1965-1969
Effect of insulin on GLUT4 cell surface content and turnover rate in human skeletal muscle as measured by the exofacial bis-mannose photolabeling technique
Lund S; Holman GD; Zierath JR; Rincon J; Nolte LA; Clark AE; Schmitz O; Pedersen O; WallbergHenriksson H
Article: DIABETOLOGIA. 1997;40(10):1172-1177
Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism
Shepherd PR; Nave BT; Rincon J; Haigh RJ; Foulstone E; Proud C; Zierath JR; Siddle K; WallbergHenriksson H
Article: JOURNAL OF CLINICAL INVESTIGATION. 1997;100(3):671-677
Muscle-specific transgenic complementation of GLUT4-deficient mice - Effects on glucose but not lipid metabolism
Tsao TS; Stenbit AE; Li J; Houseknecht KL; Zierath JR; Katz EB; Charron MJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(30):19000-19007
Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.
Shepherd PR; Nave BT; Rincon J; Nolte LA; Bevan AP; Siddle K; Zierath JR; WallbergHenriksson H
Article: DIABETES. 1997;46(3):524-527
Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
Bjornholm M; Kawano Y; Lehtihet M; Zierath JR
Article: DIABETOLOGIA. 1996;39(10):1180-1189
Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM
Zierath JR; He L; Guma A; Wahlstrom EO; Klip A; WallbergHenriksson H
Article: JOURNAL OF INTERNAL MEDICINE. 1996;240(3):115-124
C-peptide revisited - New physiological effects and therapeutic implications
Wahren J; Johansson BL; WallbergHenriksson H; Linde B; FernqvistForbes E; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1996;271(3):E593-E600
Intact glucose transport in morphologically altered denervated skeletal muscle from quadriplegic patients
Aksnes AK; Hjeltnes N; Wahlstrom EO; Katz A; Zierath JR; WallbergHenriksson H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(19):11347-11355
Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin.
Houseknecht KL; Zhu AX; Gnudi L; Hamann A; Zierath JR; Tozzo E; Flier JS; Kahn BB
Article: DIABETES. 1996;45(5):615-621
Mechanisms behind insulin resistance in rat skeletal muscle after oophorectomy and additional testosterone treatment
Rincon J; Holmang A; Wahlstrom EO; Lonnroth P; Bjorntorp P; Zierath JR; WallbergHenriksson H
Article: DIABETOLOGIA. 1996;39(3):306-313
C-peptide stimulates glucose transport in isolated human skeletal muscle independent of insulin receptor and tyrosine kinase activation
Zierath JR; Handberg A; Tally M; WallbergHenriksson H
Article: BIOCHEMICAL JOURNAL. 1995;311(Pt 2):517-521
CARRIER-MEDIATED FRUCTOSE UPTAKE SIGNIFICANTLY CONTRIBUTES TO CARBOHYDRATE-METABOLISM IN HUMAN SKELETAL-MUSCLE
ZIERATH JR; NOLTE LA; WAHLSTROM E; GALUSKA D; SHEPHERD PR; KAHN BB; WALLBERGHENRIKSSON H
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1995;268(4):E613-E622
INSULIN INDUCES TRANSLOCATION OF GLUT-4 GLUCOSE TRANSPORTERS IN HUMAN SKELETAL-MUSCLE
GUMA A; ZIERATH JR; WALLBERGHENRIKSSON H; KLIP A
Article: DIABETES. 1995;44(3):347-353
Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.
Echwald SM; Bjørbaek C; Hansen T; Clausen JO; Vestergaard H; Zierath JR; Printz RL; Granner DK; Pedersen O
Article: CLINICAL SCIENCE. 1995;88(3):301-306
DEVELOPMENT OF DECREASED INSULIN-INDUCED GLUCOSE-TRANSPORT IN SKELETAL-MUSCLE OF GLUCOSE-INTOLERANT HYBRIDS OF DIABETIC GK RATS
NOLTE LA; ABDELHALIM SM; MARTIN IK; GUENIFI A; ZIERATH JR; OSTENSON CG; WALLBERGHENRIKSSON H
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Letter: CELL METABOLISM. 2024;36(5):882-883
Exploratory physiological experiments are not clinical trials
Richter EA; James DE; Kirwan JP; Zierath JR
Review: CELL METABOLISM. 2024;36(2):278-300
Exercise induces tissue-specific adaptations to enhance cardiometabolic health
Ashcroft SP; Stocks B; Egan B; Zierath JR
Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2023;24(9):607-632
Exercise metabolism and adaptation in skeletal muscle
Smith JAB; Murach KA; Dyar KA; Zierath JR
Letter: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(11):713
Reply to 'Lactate as a major myokine and exerkine'
Chow LS; Gerszten RE; Taylor JM; Pedersen BK; van Praag H; Trappe S; Febbraio MA; Galis ZS; Gao Y; Haus JM; Lanza IR; Lavie CJ; Lee C-H; Lucia A; Moro C; Pandey A; Robbins JM; Stanford KI; Thackray AE; Villeda S; Watt MJ; Xia A; Zierath JR; Goodpaster BH; Snyder M
Review: ENDOCRINE REVIEWS. 2022;43(4):654-677
Post-translational Modifications: The Signals at the Intersection of Exercise, Glucose Uptake, and Insulin Sensitivity
Stocks B; Zierath JR
Review: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(5):273-289
Exerkines in health, resilience and disease
Chow LS; Gerszten RE; Taylor JM; Pedersen BK; van Praag H; Trappe S; Febbraio MA; Galis ZS; Goo Y; Haus JM; Lanza IR; Lavie CJ; Lee C-H; Lucia A; Moro C; Pandey A; Robbins JM; Stanford KI; Thackray AE; Villeda S; Watt MJ; Xia A; Zierath JR; Goodpaster BH; Snyder MP
Review: JOURNAL OF PHYSIOLOGY. 2022;600(5):1027-1036
Zeitgebers of skeletal muscle and implications for metabolic health
Gabriel BM; Zierath JR
Editorial comment: METABOLISM: CLINICAL AND EXPERIMENTAL. 2021;119:154769
COVID-19 editorial: mechanistic links and therapeutic challenges for metabolic diseases one year into the COVID-19 pandemic
Tessier CM; Kokkinos A; Mingrone G; Koliaki C; Zierath JR; Mantzoros CS
Review: CELL. 2021;184(6):1530-1544
Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
Pillon NJ; Loos RJF; Marshall SM; Zierath JR
Review: CURRENT OPINION IN LIPIDOLOGY. 2021;32(1):16-23
The role of the molecular circadian clock in human energy homeostasis
Dollet L; Pendergrast LA; Zierath JR
Review: DIABETOLOGIA. 2020;63(11):2253-2259
Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men
Hawley JA; Sassone-Corsi P; Zierath JR
Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):5142
Author Correction: Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression.
Lundell LS; Parr EB; Devlin BL; Ingerslev LR; Altıntaş A; Sato S; Sassone-Corsi P; Barrès R; Zierath JR; Hawley JA
Review: DIABETOLOGIA. 2020;63(8):1491-1499
Train like an athlete: applying exercise interventions to manage type 2 diabetes
Savikj M; Zierath JR
Editorial comment: CURRENT DIABETES REPORTS. 2019;19(11):118
Major Advances and Discoveries in Diabetes-2019 in Review
Zierath JR
Corrigendum: JOURNAL OF ENDOCRINOLOGY. 2019;243(2):X1
The estrogen receptor α-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice: potential molecular mechanisms (vol 199, pg 275, 2008)
Lundholm L; Bryzgalova G; Gao H; Portwood N; Falt S; Berndt KD; Dicker A; Galuska D; Zierath JR; Gustafsson J-A; Efendic S; Dahlman-Wright K; Khan A
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2019;30(9):603-617
Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis
Massart J; Zierath JR
Review: NATURE REVIEWS ENDOCRINOLOGY. 2019;15(4):197-206
Circadian rhythms and exercise - re-setting the clock in metabolic disease
Gabriel BM; Zierath JR
Review: JOURNAL OF PHYSIOLOGY. 2019;597(6):1439-1450
Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue
Dollet L; Zierath JR
Other: CELL METABOLISM. 2018;28(3):329
John O. Holloszy (1933-2018) Obituary
Zierath JR; Hagberg JM; Coyle EF
Corrigendum: SCIENTIFIC REPORTS. 2018;8(1):5008
Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans (vol 7, 2017)
Laker RC; Garde C; Camera DM; Smiles WJ; Zierath JR; Hawley JA; Barres R
Editorial comment: CELL METABOLISM. 2017;25(5):978-984
Exercise Metabolism
Stanford K; Loos R; Evans R; Zierath JR; Leinwand LA; Rosenzweig A; Spiegelman B; Mott R; Helenius T; Febbraio MA; Weigert C; Goodpaster BH; Granger A; Panda S; Joyner MJ; Gibala M; Hawley J; Messmer-Blust A; Emambokus N
Review: CELL METABOLISM. 2017;25(5):1000-1011
The Limits of Exercise Physiology: From Performance to Health
Gabriel BM; Zierath JR
Editorial comment: CELL. 2016;167(5):1155-1158
Building Bridges through Scientific Conferences
Zierath JR
Editorial comment: CELL METABOLISM. 2016;24(2):342-342.e1
SnapShot: Exercise Metabolism
Egan B; Hawley JA; Zierath JR
Review: NATURE REVIEWS ENDOCRINOLOGY. 2016;12(8):441-451
The role of diet and exercise in the transgenerational epigenetic landscape of T2DM
Barres R; Zierath JR
Review: CELL METABOLISM. 2016;23(6):1034-1047
Exercise Promotes Healthy Aging of Skeletal Muscle
Cartee GD; Hepple RT; Bamman MM; Zierath JR
Corrigendum: DIABETOLOGIA. 2015;58(12):2899
Turning the page (vol 58, pg 2685, 2015)
Zierath JR
Editorial comment: DIABETOLOGIA. 2015;58(12):2685-2687
Turning the page
Zierath JR
Editorial comment: DIABETOLOGIA. 2015;58(8):1685-1687
Diabetologia at 50: celebrating half a century of progress in diabetes research and care
Zierath JR
Review: CELL METABOLISM. 2015;22(1):25-30
Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us?
Zierath JR; Wallberg-Henriksson H
Editorial comment: CELL METABOLISM. 2015;21(5):654-657
Women in Metabolism: Part I
Kahn B; Simon MC; Zhang BB; Zierath JR; Muoio DM; Moore KJ; Cannon B; Haigis M; Schoonjans K; Mandrup S; Clement K; Andrews NC
Editorial comment: NATURE REVIEWS ENDOCRINOLOGY. 2015;11(4):198-200
Exercise remodels subcutaneous fat tissue and improves metabolism
Wallberg-Henriksson H; Zierath JR
Other: CELL. 2015;161(1):173-174
How to Stop the Obesity Epidemic?
Chen Z; Zierath J; Kahn CR; Spiegelman B; O'Rahilly S; Bruning JC
Review: CELL. 2014;159(4):738-749
Integrative Biology of Exercise
Hawley JA; Hargreaves M; Joyner MJ; Zierath JR
Review: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2014;307(9):C774-C787
Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes
Al-Khalili L; Barbosa TDC; Ostling J; Massart J; Garrido Cuesta P; Osler ME; Katayama M; Nystrom A-C; Oscarsson J; Zierath JR
Review: DRUG DISCOVERY TODAY. 2014;19(7):1010-1014
Dynamic epigenetic responses to muscle contraction
Rasmussen M; Zierath JR; Barres R
Corrigendum: CELL REPORTS. 2013;3(5):1755
Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation (vol 3, pg 1020, 2013)
Barres R; Kirchner H; Rasmussen M; Yan J; Kantor FR; Krook A; Naslund E; Zierath JR
Review: TRENDS IN CELL BIOLOGY. 2013;23(5):203-209
Epigenetic flexibility in metabolic regulation: disease cause and prevention?
Kirchner H; Osler ME; Krook A; Zierath JR
Review: CELL METABOLISM. 2013;17(2):162-184
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan B; Zierath JR
Editorial comment: DIABETOLOGIA. 2012;55(1):1-2
Remembering our classics: then and now
Zierath JR
Published conference paper: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2011;93(4):897S-8900
DNA methylation in metabolic disorders
Barres R; Zierath JR
Editorial comment: DIABETOLOGIA. 2011;54(1):1-3
Keeping ahead of the fast pace of science
Zierath JR
Review: LAKARTIDNINGEN. 2010;107(45):2802-2805
[Molecular mechanisms underlying insulin resistance in skeletal muscle].
Zierath JR; Krook A
Review: DIABETOLOGIA. 2009;52(7):1231-1239
Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA
Krook A; Zierath JR
Editorial comment: CELL. 2009;137(1):22-24
A New Twist on Brown Fat Metabolism
Wallberg-Henriksson H; Zierath JR
Published conference paper: INTERNATIONAL JOURNAL OF OBESITY. 2008;32:S18-S23
Exercise-induced phospho-proteins in skeletal muscle
Deshmukh AS; Hawley JA; Zierath JR
Review: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2008;295(3):E545-E552
Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle
Long YC; Zierath JR
Review: ENDOCRINOLOGY. 2008;149(3):935-941
Minireview:: Adenosine 5′-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle
Osler ME; Zierath JR
Editorial comment: ACTA PHYSIOLOGICA. 2008;192(1):1
Xth International Symposium on Insulin Receptors and Insulin Action
Zierath JR
Editorial comment: DIABETOLOGIA. 2007;50(7):1362-1364
Fighting the battle of the bulge: exercise training in early-onset type 2 diabetes
Osler ME; Zierath JR
Editorial comment: CELL METABOLISM. 2007;5(3):161-163
The path to insulin resistance: Paved with ceramides?
Zierath JR
Published conference paper: CELL BIOCHEMISTRY AND BIOPHYSICS. 2007;48(2-3):103-113
Insulin signaling and glucose transport in insulin resistant human skeletal muscle
Karlsson HKR; Zierath JR
Review: ESSAYS IN BIOCHEMISTRY. 2006;42:1-12
Signalling mechanisms in skeletal muscle: Role in substrate selection and muscle adaptation
Hawley JA; Hargreaves M; Zierath JR
Review: JOURNAL OF CLINICAL INVESTIGATION. 2006;116(7):1776-1783
AMP-activated protein kinase signaling in metabolic regulation
Long YC; Zierath JR
Editorial comment: DIABETOLOGIA. 2005;48(12):2451-2453
Fine-tuning insulin and nitric oxide signalling by turning up the AMPs: new insights into AMP-activated protein kinase signalling
Long YC; Zierath JR
Review: CURRENT DIABETES REVIEWS. 2005;1(2):167-174
Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes.
Bouzakri K; Koistinen HA; Zierath JR
Review: CURRENT MOLECULAR MEDICINE. 2005;5(3):341-348
Role of AMP-activated protein kinase in the control of glucose homeostasis
Barnes BR; Zierath JR
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 2005;33(Pt 2):354-357
Insulin signal transduction in human skeletal muscle:: identifying the defects in type II diabetes
Björnholm M; Zierath JR
Editorial comment: IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL. 2005;8(2):121-123
Kinases in diabetes - Part II - 11-12 November 2004, Manchester, UK
Zierath JR
Editorial comment: IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL. 2005;8(2):118-120
Kinases in diabetes - Part I - 11-12 November 2004, Manchester, UK
Zierath JR
Editorial comment: ACTA PHYSIOLOGICA. 2005;183(1):1-2
Theme: Skeletal muscle and adipose tissue metabolism - Regulation, exercise, diabetes and ageing - Foreword
Zierath JR; Handberg A; Jensen J
Letter: ACTA PHYSIOLOGICA. 2005;183(1):125-126
Integration of mathematical and experimental approaches to resolve insulin signalling
Sögård P; Harlén M; Svensson LT; Zierath JR; Nilsson P
Editorial comment: PLOS BIOLOGY. 2004;2(10):e348
Skeletal muscle fiber type: Influence on contractile and metabolic properties
Zierath JR; Hawley JA
Published conference paper: PROCEEDINGS OF THE NUTRITION SOCIETY. 2004;63(2):227-232
Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle
Long YC; Widegren U; Zierath JR
Review: EXERCISE AND SPORT SCIENCES REVIEWS. 2004;32(1):4-8
Integration of metabolic and mitogenic signal transduction in skeletal muscle
Hawley JA; Zierath JR
Editorial comment: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 2003;26(7):690-692
Skeletal muscle insulin resistance: Is it important for the pathogenesis of Type 2 diabetes after all?
Koistinen HA; Zierath JR
Review: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY AND DIABETES. 2003;111(4):191-197
Analysis of insulin signaling pathways through comparative genomics. Mapping mechanisms for insulin resistance in type 2 (non-insulin-dependent) diabetes mellitus
Lake S; Krook A; Zierath JR
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):219
Effects of diet and exercise on the regulation of PPARα, δ and γ expression in rat skeletal muscle and visceral adipose tissue
Kannisto K; Chibalin A; Zierath JR; Hamsten A; Ehrenborg E
Review: JOURNAL OF APPLIED PHYSIOLOGY. 2002;93(2):773-781
Exercise effects of muscle insulin signaling and action - Invited review: Exercise training-induced changes in insulin signaling in skeletal muscle
Zierath JR
Review: THE FASEB JOURNAL. 2002;16(10):1163-1176
Analysis of paradoxical observations on the association between leptin and insulin resistance
Ceddia RB; Koistinen HA; Zierath JR; Sweeney G
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2002;967:120-134
From receptor to effector: Insulin signal transduction in skeletal muscle from type II diabetic patients
Zierath JR; Wallberg-Henriksson H
Review: ANNALS OF MEDICINE. 2002;34(6):410-418
Regulation of glucose transport in human skeletal muscle
Koistinen HA; Zierath JR
Review: ACTA PHYSIOLOGICA. 2001;172(3):227-238
Mitogen-activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction
Widegren U; Ryder JW; Zierath JR
Review: MOLECULAR MEMBRANE BIOLOGY. 2001;18(3):205-211
GLUT4: a key player regulating glucose homeostasis? Insights from transgenic and knockout mice
Wallberg-Henriksson H; Zierath JR
Published conference paper: ACTA PHYSIOLOGICA. 2001;171(3):249-257
Intracellular mechanisms underlying increases in glucose uptake in response to insulin or exercise in skeletal muscle
Ryder JW; Chibalin AV; Zierath JR
Review: FRONTIERS IN BIOSCIENCE - LANDMARK. 2001;6:D154-D163
Skeletal muscle and insulin sensitivity: Pathophysiological alterations
Ryder JW; Gilbert M; Zierath JR
Review: DIABETOLOGIA. 2000;43(7):821-835
Insulin action and insulin resistance in human skeletal muscle
Zierath JR; Krook A; Wallberg-Henriksson H
Review: SPORTS MEDICINE. 1998;25(1):25-35
Exercise in the management of non-insulin-dependent diabetes mellitus
Wallberg-Henriksson H; Rincon J; Zierath JR
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1998;441:73-85
Insulin signaling and glucose transport in insulin resistant skeletal muscle - Special reference to GLUT4 transgenic and GLUT4 knockout mice
Galuska D; Ryder J; Kawano Y; Charron MJ; Zierath JR
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1997;25(3):963-968
Metabolic and molecular consequences of modifying GLUT4 expression in skeletal muscle
Charron MJ; Katz EB; Zierath JR
Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 1996;7(2):295-307
Glucose transporters and diabetes
Zierath JR; Houseknecht KL; Kahn BB
Other: DIABETES. 1995;44(11):1345-1348
HYPERGLYCEMIA ACTIVATES GLUCOSE-TRANSPORT IN RAT SKELETAL-MUSCLE VIA A CA2+-DEPENDENT MECHANISM
NOLTE LA; RINCON J; WAHLSTROM EO; CRAIG BW; ZIERATH JR; WALLBERGHENRIKSSON H
Review: ACTA PHYSIOLOGICA SCANDINAVICA, SUPPLEMENT. 1995;626:1-96
In vitro studies of human skeletal muscle: hormonal and metabolic regulation of glucose transport.
Zierath JR
Review: ACTA PHYSIOLOGICA. 1995;155:11-96
IN-VITRO STUDIES OF HUMAN SKELETAL-MUSCLE - HORMONAL AND METABOLIC-REGULATION OF GLUCOSE-TRANSPORT - INTRODUCTION
ZIERATH JR
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Professor, Fysiologi och farmakologi, Karolinska Institutet, 2009-
Professor, Molekylär medicin och kirurgi, Karolinska Institutet, 2006-

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Docent, inriktning: fysiologi med inriktning metabolism, Karolinska Institutet, 1998

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