Jonas Fuxe

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA. 2023;28(1):25
TGFß1 Stimulates Lymphatic Endothelial Cells to Produce IL7 and IL15, Which Act as Chemotactic Factors for Breast Cancer Cells with Mesenchymal Properties
Giotopoulou N; Shi W; Parniewska MM; Sun W; Fuxe J
Article: SEMINARS IN CANCER BIOLOGY. 2022;86(Pt 3):166-179
Sex dimorphism in the tumor microenvironment - From bench to bedside and back
He F; Furones AR; Landegren N; Fuxe J; Sarhan D
Article: BIOLOGY. 2021;10(6):521
Nuclear Syndecan-1 Regulates Epithelial-Mesenchymal Plasticity in Tumor Cells
Kumar-Singh A; Parniewska MM; Giotopoulou N; Javadi J; Sun W; Szatmari T; Dobra K; Hjerpe A; Fuxe J
Article: BIOMOLECULES. 2020;10(12):E1621-1621
Different Regulation of Glut1 Expression and Glucose Uptake during the Induction and Chronic Stages of TGFβ1-Induced EMT in Breast Cancer Cells
Nilchian A; Giotopoulou N; Sun W; Fuxe J
Article: JOURNAL OF INFECTIOUS DISEASES. 2020;222(12):2041-2051
Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques
Nilchian A; Plant E; Parniewska MM; Santiago A; Rossignoli A; Skogsberg J; Hedin U; Matic L; Fuxe J
Article: CELL DEATH AND DISEASE. 2020;11(10):920
Mutant CFTR Drives TWIST1 mediated epithelial-mesenchymal transition
Quaresma MC; Pankonien I; Clarke LA; Sousa LS; Silva IAL; Railean V; Dousova T; Fuxe J; Amaral MD
Article: BIOMOLECULES. 2020;10(7):E1034-1034
Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells
Kumar-Singh A; Shrinet J; Parniewska MM; Fuxe J; Dobra K; Hjerpe A
Article: CANCER RESEARCH. 2019;79(1):47-60
CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial-Mesenchymal Plasticity in Breast Cancer
Nilchian A; Johansson J; Ghalali A; Asanin ST; Santiago A; Rosencrantz O; Sollerbrant K; Vincent CT; Sund M; Stenius U; Fuxe J
Article: MOLECULAR ONCOLOGY. 2017;11(7):781-791
Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system
Karlsson MC; Gonzalez SF; Welin J; Fuxe J
Article: SCIENTIFIC REPORTS. 2016;6:35712
Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves
Maleki S; Kjellqvist S; Paloschi V; Magne J; Branca RMM; Du L; Hultenby K; Petrini J; Fuxe J; Lehtio J; Franco-Cereceda A; Eriksson P; Bjorck HM
Article: CELL REPORTS. 2016;15(9):2000-2011
Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
Georgoudaki A-M; Prokopec KE; Boura VF; Hellqvist E; Sohn S; Ostling J; Dahan R; Harris RA; Rantalainen M; Klevebring D; Sund M; Brage SE; Fuxe J; Rolny C; Li F; Ravetch JV; Karlsson MCI
Article: ONCOGENE. 2016;35(6):748-760
TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis
Pang M-F; Georgoudaki A-M; Lambut L; Johansson J; Tabor V; Hagikura K; Jin Y; Jansson M; Alexander JS; Nelson CM; Jakobsson L; Betsholtz C; Sunds M; Karlsson MCI; Fuxe J
Article: BMJ OPEN DIABETES RESEARCH & CARE. 2016;4(1):e000219
Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes
Hodik M; Anagandula M; Fuxe J; Krogvold L; Dahl-Jorgensen K; Hyoty H; Sarmiento L; Frisk G
Article: AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2015;308(7):L658-L671
Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma
Johnson JR; Folestad E; Rowley JE; Noll EM; Walker SA; Lloyd CM; Rankin SM; Pietras K; Eriksson U; Fuxe J
Article: FRONTIERS IN ONCOLOGY. 2015;5:3
TGF-β1-induced epitheal-mesenchymal transition promotes monocyte/macrophage properties in breast cancer cells
Johansson J; Tabor V; Wikell A; Jalkanen S; Fuxe J
Article: DEVELOPMENT. 2014;141(23):4489-4499
Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain
Arnold TD; Niaudet C; Pang M-F; Siegenthaler J; Gaengel K; Jung B; Ferrero GM; Mukouyama Y-S; Fuxe J; Akhurst R; Betsholtz C; Sheppard D; Reichardt LF
Article: ONCOGENESIS. 2014;3(11):e125
C/EBPβ expression is an independent predictor of overall survival in breast cancer patients by MHCII/CD4-dependent mechanism of metastasis formation
Kurzejamska E; Johansson J; Jirstrom K; Prakash V; Ananthaseshan S; Boon L; Fuxe J; Religa P
Article: ONCOGENE. 2013;32(50):5614-5624
MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer
Johansson J; Berg T; Kurzejamska E; Pang M-F; Tabor V; Jansson M; Roswall P; Pietras K; Sund M; Religa P; Fuxe J
Article: CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY. 2013;4(6):e38
Human Enterovirus Species B in Ileocecal Crohn's Disease
Nystrom N; Berg T; Lundin E; Skog O; Hansson I; Frisk G; Juko-Pecirep I; Nilsson M; Gyllensten U; Finkel Y; Fuxe J; Wanders A
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2013;210(3):563-579
Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination
Anderberg C; Cunha SI; Zhai Z; Cortez E; Pardali E; Johnson JR; Franco M; Paez-Ribes M; Cordiner R; Fuxe J; Johansson BR; Goumans M-J; Casanovas O; ten Dijke P; Arthur HM; Pietras K
Journal article: JOURNAL OF CELL BIOLOGY. 2013;200(4):i10
Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination
Anderberg C; Cunha SI; Zhai Z; Cortez E; Pardali E; Johnson JR; Franco M; Páez-Ribes M; Cordiner R; Fuxe J; Johansson BR; Goumans M-J; Casanovas O; Dijke PT; Arthur HM; Pietras K
Article: CANCER BIOLOGY & THERAPY. 2012;13(14):1454-1462
Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate
Wintzell M; Lofstedt L; Johansson J; Pedersen AB; Fuxe J; Shoshan M
Article: DEVELOPMENTAL CELL. 2012;23(3):587-599
The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2
Gaengel K; Niaudet C; Hagikura K; Siemsen BL; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Article: PLOS ONE. 2012;7(5):e37523
Essential Role of the Coxsackie - and Adenovirus Receptor (CAR) in Development of the Lymphatic System in Mice
Mirza M; Pang M-F; Zaini MA; Haiko P; Tammela T; Alitalo K; Philipson L; Fuxe J; Sollerbrant K
Article: AMERICAN JOURNAL OF PATHOLOGY. 2011;178(6):2897-2909
Pericyte Requirement for Anti-Leak Action of Angiopoietin-1 and Vascular Remodeling in Sustained Inflammation
Fuxe J; Tabruyn S; Colton K; Zaid H; Adams A; Baluk P; Lashnits E; Morisada T; Le T; O'Brien S; Epstein DM; Koh GY; McDonald DM
Article: PLOS ONE. 2011;6(1):e16175
Chronic Respiratory Aeroallergen Exposure in Mice Induces Epithelial-Mesenchymal Transition in the Large Airways
Johnson JR; Roos A; Berg T; Nord M; Fuxe J
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;177(6):3233-3243
Angiopoietin-2-Driven Vascular Remodeling in Airway Inflammation
Tabruyn SP; Colton K; Morisada T; Fuxe J; Wiegand SJ; Thurston G; Coyle AJ; Connor J; McDonald DM
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;176(4):2009-2018
Angiopoietin/Tie2 Signaling Transforms Capillaries into Venules Primed for Leukocyte Trafficking in Airway Inflammation
Fuxe J; Lashnits E; O'Brien S; Baluk P; Tabruyn SP; Kuhnert F; Kuo C; Thurston G; McDonald DM
Article: ONCOLOGY REPORTS. 2009;22(5):1063-1068
Estrogen receptor-β expression in human laryngeal carcinoma: Correlation with the expression of epithelial-mesenchymal transition specific biomarkers
Goulioumis AK; Fuxe J; Varakis J; Repanti M; Goumas P; Papadaki H
Article: NATURE CELL BIOLOGY. 2009;11(8):943-950
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial-mesenchymal transition
Vincent T; Neve EPA; Johnson JR; Kukalev A; Rojo F; Albanell J; Pietras K; Virtanen I; Philipson L; Leopold PL; Crystal RG; Garcia de Herreros A; Moustakas A; Pettersson RF; Fuxe J
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2007;204(10):2349-2362
Functionally specialized junctions between endothelial cells of lymphatic vessels
Baluk P; Fuxe J; Hashizume H; Romano T; Lashnits E; Butz S; Vestweber D; Corada M; Molendini C; Dejana E; McDonald DM
Journal article: JOURNAL OF CELL BIOLOGY. 2007;178(7):i15
Functionally specialized junctions between endothelial cells of lymphatic vessels
Baluk P; Fuxe J; Hashizume H; Romano T; Lashnits E; Butz S; Vestweber D; Corada M; Molendini C; Dejana E; McDonald DM
Article: AMERICAN JOURNAL OF PATHOLOGY. 2006;169(6):2245-2253
Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-κB
Bu D-X; Hemdahl A-L; Gabrielsen A; Fuxe J; Zhu C; Eriksson P; Yan Z-Q
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(9):1566-1580
The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis
Raschperger E; Thyberg J; Pettersson S; Philipson L; Fuxe J; Pettersson RF
Journal article: THE FASEB JOURNAL. 2006;20(5):a1148-a1149
Two types of endothelial junction in lymphatic vessels of mouse airways
Baluk P; Fuxe J; Hashizume H; Romano T; Turatti F; Dejana E; McDonald DM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(1):796-804
CLMP, a novel member of the CTX family and a new component of epithelial tight junctions
Raschperger E; Engstrom U; Pettersson RF; Fuxe J
Article: EXPERIMENTAL CELL RESEARCH. 2003;288(1):70-83
VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum
Neve EPA; Svensson K; Fuxe J; Pettersson RF
Article: THE FASEB JOURNAL. 2003;17(2):764-766
Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16^INK4A/pRb
Veitonmäki N; Fuxe J; Hultdin M; Roos G; Pattersson RF; Cao Y
Article: INTERNATIONAL JOURNAL OF CANCER. 2003;103(6):723-729
Expression of the coxsackie and adenovirus receptor in human astrocytic tumors and xenografts
Fuxe J; Liu L; Malin S; Philipson L; Collins VP; Pettersson RF
Article: CANCER GENE THERAPY. 2002;9(11):908-916
The combination of HSV-tk and endostatin gene therapy eradicates orthotopic human renal cell carcinomas in nude mice
Pulkkanen KJ; Laukkanen JM; Fuxe J; Kettunen MI; Rehn M; Kannasto JM; Parkkinen JJ; Kauppinen RA; Pettersson RF; Yla-Herttuala S
Article: MOLECULAR CANCER RESEARCH. 2000;11(7):373-384
Adenovirus-mediated overexpression of p15^INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16^INK4A
Fuxe J; Akusjärvi G; Goike HM; Roos G; Collins VP; Pettersson RF
Article: ONCOGENE. 2000;19(13):1724-1728
Translation of p15.5^INK4B, an N-terminally extended and fully active form of p15^INK4B, is initiated from an upstream GUG codon
Fuxe J; Raschperger E; Pettersson RF
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Preprint: BIORXIV. 2024
CXCR2-mediated recruitment of adaptive NK cells with NKG2C/HLA-E dependent antigen-specific memory enhances tumor killing in ovarian cancer
Sun Y; Rodgers-Furones A; Gultekin O; Khare S; Neo SY; Shi W; Galceran LM; Lam K-P; Dasgupta R; Fuxe J; Salehi S; Lehti K; Sarhan D
Preprint: RESEARCH SQUARE. 2023
TGF-beta1 stimulates lymphatic endothelial cells to produce IL-7 and IL-15, which act as chemotactic factors for breast cancer cells with EMT properties
Giotopoulou N; Parniewska MM; Shi W; Sun W; Fuxe J
Book chapter: HANDBOOK OF CANCER AND IMMUNOLOGY. 2023;p. 1-22
Epithelial-Mesenchymal Plasticity: A Link Between Inflammation and Cancer Metastasis
Parniewska MM; Shi W; Gatto F; Monzur S; Slager J; Fuxe J
Corrigendum: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2021;22(12):834
Guidelines and definitions for research on epithelial-mesenchymal transition (vol 21, pg 341, 2020)
Yang J; Antin P; Berx G; Blanpain C; Brabletz T; Bronner M; Campbell K; Cano A; Casanova J; Christofori G; Dedhar S; Derynck R; Ford HL; Fuxe J; Garcia de Herreros A; Goodall GJ; Hadjantonakis A-K; Huang RYJ; Kalcheim C; Kalluri R; Kang Y; Khew-Goodall Y; Levine H; Liu J; Longmore GD; Mani SA; Massague J; Mayor R; McClay D; Mostov KE; Newgreen DF; Nieto MA; Puisieux A; Runyan R; Savagner P; Stanger B; Stemmler MP; Takahashi Y; Takeichi M; Theveneau E; Thiery JP; Thompson EW; Weinberg RA; Williams ED; Xing J; Zhou BP; Sheng G
Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2020;21(6):341-352
Guidelines and definitions for research on epithelial-mesenchymal transition
Yang J; Antin P; Berx G; Blanpain C; Brabletz T; Bronner M; Campbell K; Cano A; Casanova J; Christofori G; Dedhar S; Derynck R; Ford HL; Fuxe J; Garcia de Herreros A; Goodall GJ; Hadjantonakis A-K; Huang RJY; Kalcheim C; Kalluri R; Kang Y; Khew-Goodall Y; Levine H; Liu J; Longmore GD; Mani SA; Massague J; Mayor R; McClay D; Mostov KE; Newgreen DF; Nieto MA; Puisieux A; Runyan R; Savagner P; Stanger B; Stemmler MP; Takahashi Y; Takeichi M; Theveneau E; Thiery JP; Thompson EW; Weinberg RA; Williams ED; Xing J; Zhou BP; Sheng G
Editorial comment: SEMINARS IN CANCER BIOLOGY. 2017;47:168-169
EMT, inflammation and metastasis
Vincent CT; Fuxe J
Book chapter: CANCER AND INFLAMMATION MECHANISMS. 2014;p. 23-39
Epithelial–Mesenchymal Transition: A Link between Cancer and Inflammation
Fuxe J; Karlsson MCI
Conference publication: ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. 2014;10:113
C/EBPB EXPRESSION IS AN INDEPENDENT PREDICTOR OF OVERALL SURVIVAL IN BREAST CANCER PATIENTS BY MHCII/CD4-DEPENDENT MECHANISM OF METASTASIS FORMATION
Kurzejamska E; Johansson J; Jirstrom K; Fuxe J; Religa P
Conference publication: THE FEBS JOURNAL. 2014;281:441-442
C/EBPβ expression is an independent predictor of overall survival in breast cancer patients by MHCII/CD4-dependent mechanism of metastasis formation
Kurzejamska E; Johansson J; Jirstrom K; Fuxe J; Religa P
Conference publication: ANGIOGENESIS. 2013;16(1):246-247
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
Gaengel K; Niaudet C; Hagikura K; Siemsen LB; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Corrigendum: DEVELOPMENTAL CELL. 2012;23(6):1264
The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2 (vol 23, pg 587, 2012)
Gaengel K; Niaudet C; Hagikura K; Lavina B; Muhl L; Hofmann JJ; Ebarasi L; Nystroem S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstroem M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Review: SEMINARS IN CANCER BIOLOGY. 2012;22(5-6):455-461
TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation
Fuxe J; Karlsson MCI
Conference publication: HISTOPATHOLOGY. 2012;61:28
C/EBPβ expression is an independent predictor of overall survival in breast cancer patients
Kurzejamska E; Jistrom K; Johansson J; Fuxe J; Religa P
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183:a2874
Exosome Production And Trafficking To Lymph Nodes In A Mouse Model Of Chronic Allergic Asthma
Johnson J; Berg T; Torregrosa-Paredes P; Roos AB; Roswall P; Gabrielsson S; Fuxe J
Book chapter: CANCER STEM CELLS IN SOLID TUMORS: STEM CELL BIOLOGY AND REGENERATIVE MEDICINE. 2011;p. 243-256
The Epithelial-to-Mesenchymal Transition and Cancer Stem Cells
Fuxe J
Review: CELL CYCLE. 2010;9(12):2363-2374
Transcriptional crosstalk between TGFβ and stem cell pathways in tumor cell invasion Role of EMT promoting Smad complexes
Fuxe J; Vincent T; Garcia de Herreros A
Conference publication: 2010;:a3962
Pericytes And Vascular Smooth Muscle Cells Contribute To Airway Remodeling In Asthma
Johnson J; Folestad E; Eriksson U; Fuxe J
Thesis / dissertation: 2001
p16INK4A and p15INK4B in senescence, immortalization and cancer : gene transfer by adenovirus vectors
Fuxe, Jonas

Anställningar

Forskare, Laboratoriemedicin, Karolinska Institutet, 2020-

Examina och utbildning

Docent, Cellbiologi, Karolinska Institutet, 2011
MEDICINE DOKTORSEXAMEN, Institutionen för cell- och molekylärbiologi, Karolinska Institutet, 2001

Uppdrag

Prefekt, Laboratoriemedicin, Karolinska Institutet, 2023-

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