Johan Hartman

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Professor i tumörpatologi vid Karolinska Institutet och överläkare i klinisk patologi vid Karolinska Universitetssjukhuset. Specialistområde är bröstsjukdomar med ämnesområdesansvar för bröstpatologi. Sedan 2020 är Johan vetenskaplig sekreterare för svensk förening för patologi. Han är medgrundare till Stratipath, ett spinn-off baserat på AI-forskning vid Karolinska Institutet med målsättning att förbättra diagnostiken av cancerpatienter.
Mellan 2017-2022 medlem och sammankallande i bröst-KVAST och representant för patologi i Nationella vårdprogramgruppen för bröstcancer.
Nuvarande vetenskaplig rådgivare till Socialstyrelsen.

Forskningsbeskrivning

Johans forskargrupp arbetar med bröstcancerdiagnostik, huvudsakligen fokuserad på individanpassad behandlingsprediktion. Målsättningen är att kunna ge rätt behandling till rätt patient. I forskargruppen ingår läkare, bioinformatiker och experiementalla forskare. Forskargruppen arbetar mycket nära forskare inom andra discipliner. Forskningen inkluderar digital bildanalys av biomarkörer, organotypiska patientderiverade ex vivo modeller mm.
Johan har publicerat >
100 vetenskapliga artiklar varav >
40 i high-impact tidskrifter (Cell, Science, PNAS etc), totalt >
10, 000 citeringar.

Undervisning

Tidigare huvudhandledare för fem doktorander (Ran Ma, Gustaf Rosin, Karthik Gowindasamy, Gustav Stålhammar, Stephanie Robertson), pågående huvudhandledare för tre doktorander. Regelbunden föreläsare inom patologi och tumörbiologi vid Karolinska Institutet på grund- och avancerad nivå.

Artiklar

Journal article: BREAST CANCER RESEARCH. 2024;26(1):123
Validation of an AI-based solution for breast cancer risk stratification using routine digital histopathology images
Sharma A; Lovgren SK; Eriksson KL; Wang Y; Robertson S; Hartman J; Rantalainen M
Article: GENOME BIOLOGY. 2024;25(1):214
Inferring clonal somatic mutations directed by X chromosome inactivation status in single cells
Demirci I; Larsson AJM; Chen X; Hartman J; Sandberg R; Frisen J
Article: BREAST CANCER RESEARCH AND TREATMENT. 2024;206(1):163-175
Clinical evaluation of deep learning-based risk profiling in breast cancer histopathology and comparison to an established multigene assay
Wang Y; Sun W; Karlsson E; Lovgren SK; Acs B; Rantalainen M; Robertson S; Hartman J
Journal article: BREAST CANCER RESEARCH. 2024;26(1):90
Deep learning-based risk stratification of preoperative breast biopsies using digital whole slide images
Boissin C; Wang Y; Sharma A; Weitz P; Karlsson E; Robertson S; Hartman J; Rantalainen M
Article: SCIENTIFIC REPORTS. 2024;14(1):12542
PIK3CA mutations in endocrine-resistant breast cancer
Schagerholm C; Robertson S; Toosi H; Sifakis EG; Hartman J
Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(747):eadi2952
Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis
Neo SY; Tong L; Chong J; Liu Y; Jing X; Oliveira MMS; Chen Y; Chen Z; Lee K; Burduli N; Chen X; Gao J; Ma R; Lim JP; Huo J; Xu S; Alici E; Wickstrom SL; Haglund F; Hartman J; Wagner AK; Cao Y; Kiessling R; Lam KP; Westerberg LS; Lundqvist A
Journal article: CANCER RESEARCH. 2024;84(9):po4-07-05-po4-07-05
Clinical evaluation of image-based risk profiling in breast cancer histopathology and comparison to an established gene expression assay
Robertson S; Wang Y; Sun W; Karlsson E; Lovgren SK; Rantalainen M; Hartman J
Journal article: CANCER RESEARCH. 2024;84(9):po5-13-02-po5-13-02
BRCA mutational profiles of endocrineresistant breast cancer
Karlsson E; Schagerholm C; Robertson S; Toosi H; Sifakis E; Hartman J
Journal article: CANCER RESEARCH. 2024;84(9):po3-16-04-po3-16-04
Distribution of intrinsic subtypes in endocrineresistant and endocrine-sensitive breast cancer
Schagerholm C; Robertson S; Karlsson E; Sifakis E; Hartman J
Article: BIOINFORMATICS. 2024;40(5):btae284
CopyVAE: a variational autoencoder-based approach for copy number variation inference using single-cell transcriptomics
Kurt S; Chen M; Toosi H; Chen X; Engblom C; Mold J; Hartman J; Lagergren J
Journal article: THE LANCET REGIONAL HEALTH. EUROPE. 2024;40:100886
Real-world overall survival and characteristics of patients with ER-zero and ER-low HER2-negative breast cancer treated as triple-negative breast cancer: a Swedish population-based cohort study
Acs B; Hartman J; Sönmez D; Lindman H; Johansson ALV; Fredriksson I
Article: JOURNAL OF NUCLEAR MEDICINE. 2024;65(5):700-707
Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [ 68 Ga]Ga-ABY-025: Results from a Pilot Study
Altena R; af Buren S; Blomgren A; Karlsson E; Tzortzakakis A; Brun N; Moein MM; Jussing E; Frejd FY; Bergh J; Tran TA; Hartman J; Axelsson R
Article: THE LANCET REGIONAL HEALTH. EUROPE. 2024;40:100886
Real-world overall survival and characteristics of patients with ER-zero and ER-low HER2-negative breast cancer treated as triple-negative breast cancer: a Swedish population-based cohort study.
Acs B; Hartman J; Sönmez D; Lindman H; Johansson ALV; Fredriksson I
Article: JOURNAL OF EXPERIMENTAL AND CLINICAL CANCER RESEARCH. 2024;43(1):107
A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells
Fonseca P; Cui W; Struyf N; Tong L; Chaurasiya A; Casagrande F; Zhao H; Fernando D; Chen X; Tobin NP; Seashore-Ludlow B; Lundqvist A; Hartman J; Gondor A; Ostling P; Holmgren L
Journal article: CANCER RESEARCH. 2024;84(6):6185
Generative AI for virtual HE-staining of whole slide images of unstained breast cancer tissue
Latonen L; Khan U; Koivukoski S; Hartman J; Ruusuvuori P
Article: BREAST CANCER RESEARCH. 2024;26(1):24
Prognostic impact of HER2 biomarker levels in trastuzumab-treated early HER2-positive breast cancer
Ronnlund C; Sifakis EG; Schagerholm C; Yang Q; Karlsson E; Chen X; Foukakis T; Weidler J; Bates M; Fredriksson I; Robertson S; Hartman J
Article: BRITISH JOURNAL OF SURGERY. 2024;111(2):znae037
Immune cell infiltrate in ductal carcinoma in situ and the risk of dying from breast cancer: case-control study
Rask G; Wadsten C; Acs B; Hartman J; Fredriksson I; Garmo H; Warnberg F; Sund M
Article: BREAST CANCER RESEARCH. 2024;26(1):17
Development and prognostic validation of a three-level NHG-like deep learning-based model for histological grading of breast cancer
Sharma A; Weitz P; Wang Y; Liu B; Vallon-Christersson J; Hartman J; Rantalainen M
Article: CELL REPORTS. 2023;42(12):113507
Report VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells
Banerjee K; Kerzel T; Bekkhus T; Ferreira SDS; Wallmann T; Wallerius M; Landwehr L-S; Agardy DA; Schauer N; Malmerfeldt A; Bergh J; Bartish M; Hartman J; Ostman A; Squadrito ML; Rolny C
Article: SCIENCE. 2023;382(6675):1137
Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics
Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Lu C; Mantovani G; Hagemann-Jensen M; Saarenpaa S; Jangard M; Saez-Rodriguez J; Michaelsson J; Hartman J; Lagergren J; Mold JE; Lundeberg J; Frisen J
Article: BREAST CANCER RESEARCH. 2023;25(1):123
Comparison of SP142 and 22C3 PD-L1 assays in a population-based cohort of triple-negative breast cancer patients in the context of their clinically established scoring algorithms
Sigurjonsdottir G; De Marchi T; Ehinger A; Hartman J; Bosch A; Staaf J; Killander F; Nimeus E
Journal article: ANNALS OF ONCOLOGY. 2023;34:s279
Patient characteristics and real-world outcomes in HER2 negative/ ER zero and ER low patients treated as triple-negative breast cancer in Sweden 2008-2020
Fredriksson I; Acs B; Hartman J; Sonmez D; Lindman H
Article: EUROPEAN JOURNAL OF CANCER. 2023;191:112953
Transcriptional intra-tumour heterogeneity predicted by deep learning in routine breast histopathology slides provides independent prognostic information
Wang Y; Ali MA; Vallon-Christersson J; Humphreys K; Hartman J; Rantalainen M
Article: BIOENGINEERING & TRANSLATIONAL MEDICINE. 2023;8(5):e10537
Development and characterization of a recombinant silk network for 3D culture of immortalized and fresh tumor-derived breast cancer cells
Collodet C; Blust K; Gkouma S; Stahl E; Chen X; Hartman J; Hedhammar M
Article: JOURNAL OF NUCLEAR MEDICINE. 2023;64(9):1364-1370
Human Epidermal Growth Factor Receptor 2-Targeting [⁶⁸Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer
Alhuseinalkhudhur A; Lindman H; Liss P; Sundin T; Frejd FY; Hartman J; Iyer V; Feldwisch J; Lubberink M; Ronnlund C; Tolmachev V; Velikyan I; Sorensen J
Article: SCIENTIFIC DATA. 2023;10(1):562
A Multi-Stain Breast Cancer Histological Whole-Slide-Image Data Set from Routine Diagnostics
Weitz P; Valkonen M; Solorzano L; Carr C; Kartasalo K; Boissin C; Koivukoski S; Kuusela A; Rasic D; Feng Y; Pouplier SS; Sharma A; Eriksson KL; Latonen L; Laenkholm A-V; Hartman J; Ruusuvuori P; Rantalainen M
Article: NATURE BIOTECHNOLOGY. 2023;41(8):1085-1088
Solid-phase capture and profiling of open chromatin by spatial ATAC
Llorens-Bobadilla E; Zamboni M; Marklund M; Bhalla N; Chen X; Hartman J; Frisen J; Stahl PL
Article: ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. ANNUAL INTERNATIONAL CONFERENCE. 2023;2023:1-4
Multiresolution Self-Supervised Feature Integration via Attention Multiple Instance Learning for Histopathology Analysis.
Tsiknakis N; Tzoras E; Zerdes I; Manikis GC; Acs B; Hartman J; Hatschek T; Foukakis T; Marias K
Journal article: CANCER RESEARCH. 2023;83(7):5432
Validation of spatial gene expression patterns predicted by deep convolutional neural networks from breast cancer histopathology images
Ton K; Wang Y; Pan L; Kartasalo K; Acs B; Weitz P; Zhang L; Liang Y; Hartman J; Volkonen M; Larsson C; Ruusuvuori P; Beechem J; Rantalainen M
Article: NATURE COMMUNICATIONS. 2023;14(1):982
Reconstructing clonal tree for phylo-phenotypic characterization of cancer using single-cell transcriptomics
Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O'Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
Article: CLINICAL CANCER RESEARCH. 2023;29(3):532-540
Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial
Matikas A; Johansson H; Gryback P; Bjohle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellstrom M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(1):e2209856120
Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction
Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Min ATH; Lovrot J; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
Article: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(35):4071-4082
Twenty-Year Benefit From Adjuvant Goserelin and Tamoxifen in Premenopausal Patients With Breast Cancer in a Controlled Randomized Clinical Trial
Johansson A; Dar H; Veer LJVT; Tobin NP; Perez-Tenorio G; Nordenskjold A; Johansson U; Hartman J; Skoog L; Yau C; Benz CC; Esserman LJ; Stal O; Nordenskjold B; Fornander T; Lindstrom LS
Article: MODERN PATHOLOGY. 2022;35(10):1362-1369
Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study
Acs B; Leung SCY; Kidwell KM; Arun I; Augulis R; Badve SS; Bai Y; Bane AL; Bartlett JMS; Bayani J; Bigras G; Blank A; Buikema H; Chang MC; Dietz RL; Dodson A; Fineberg S; Focke CM; Gao D; Gown AM; Gutierrez C; Hartman J; Kos Z; Laenkholm A-V; Laurinavicius A; Levenson RM; Mahboubi-Ardakani R; Mastropasqua MG; Nofech-Mozes S; Osborne CK; Penault-Llorca FM; Piper T; Quintayo MA; Rau TT; Reinhard S; Robertson S; Salgado R; Sugie T; van der Vegt B; Viale G; Zabaglo LA; Hayes DF; Dowsett M; Nielsen TO; Rimm DL
Article: ISCIENCE. 2022;25(7):104663
Using deep learning to detect patients at risk for prostate cancer despite benign biopsies
Liu B; Wang Y; Weitz P; Lindberg J; Hartman J; Wang W; Egevad L; Gronberg H; Eklund M; Rantalainen M
Article: NPJ BREAST CANCER. 2022;8(1):76
High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing
Kostecka A; Nowikiewicz T; Olszewski P; Koczkowska M; Horbacz M; Heinzl M; Andreou M; Salazar R; Mair T; Madanecki P; Gucwa M; Davies H; Skokowski J; Buckley PG; Peksa R; Srutek E; Szylberg L; Hartman J; Jankowski M; Zegarski W; Tiemann-Boege I; Dumanski JP; Piotrowski A
Article: CANCERS. 2022;14(11):2615
Real World Evaluation of the Prosigna/PAM50 Test in a Node-Negative Postmenopausal Swedish Population: A Multicenter Study
Kjallquist U; Acs B; Margolin S; Karlsson E; Kessler LE; Hernandez SG; Ekholm M; Lundgren C; Olsson E; Lindman H; Foukakis T; Matikas A; Hartman J
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(5):e004592
A_2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
Tay AHM; Prieto-Diaz R; Neo S; Tong L; Chen X; Carannante V; Onfelt B; Hartman J; Haglund F; Majellaro M; Azuaje J; Garcia-Mera X; Brea JM; Loza MI; Jespers W; Gutierrez-de-Teran H; Sotelo E; Lundqvist A
Article: NATURE CANCER. 2022;3(2):251-261
The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology
Tamborero D; Dienstmann R; Rachid MH; Boekel J; Lopez-Fernandez A; Jonsson M; Razzak A; Brana I; De Petris L; Yachnin J; Baird RD; Loriot Y; Massard C; Martin-Romano P; Opdam F; Schlenk RF; Vernieri C; Masucci M; Villalobos X; Chavarria E; Balmana J; Apolone G; Caldas C; Bergh J; Ernberg I; Frohling S; Garralda E; Karlsson C; Tabernero J; Voest E; Rodon J; Lehtio J
Article: ANNALS OF ONCOLOGY. 2022;33(1):89-98
Improved breast cancer histological grading using deep learning
Wang Y; Acs B; Robertson S; Liu B; Solorzano L; Wahlby C; Hartman J; Rantalainen M
Article: NPJ BREAST CANCER. 2021;7(1):144
Interplay between copy number alterations and immune profiles in the early breast cancer Scandinavian Breast Group 2004-1 randomized phase II trial: results from a feasibility study
Zerdes I; Simonetti M; Matikas A; Harbers L; Acs B; Boyaci C; Zhang N; Salgkamis D; Agartz S; Moreno-Ruiz P; Bai Y; Rimm DL; Hartman J; Mezheyeuski A; Bergh J; Crosetto N; Foukakis T
Article: BIOMOLECULES. 2021;11(11):1612
Independent Clinical Validation of the Automated Ki67 Scoring Guideline from the International Ki67 in Breast Cancer Working Group
Boyaci C; Sun W; Robertson S; Acs B; Hartman J
Article: CLINICAL CANCER RESEARCH. 2021;27(20):5557-5565
An Open-Source, Automated Tumor-Infiltrating Lymphocyte Algorithm for Prognosis in Triple-Negative Breast Cancer
Bai Y; Cole K; Martinez-Morilla S; Ahmed FS; Zugazagoitia J; Staaf J; Bosch A; Ehinger A; Nimeus E; Hartman J; Acs B; Rimm DL
Article: CANCER RESEARCH. 2021;81(19):5115-5126
Predicting Molecular Phenotypes from Histopathology Images: A Transcriptome-Wide Expression-Morphology Analysis in Breast Cancer
Wang Y; Kartasalo K; Weitz P; Acs B; Valkonen M; Larsson C; Ruusuvuori P; Hartman J; Rantalainen M
Article: CANCERS. 2021;13(19):4910
Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group
Van Bockstal MR; Cooks M; Nederlof I; Brinkhuis M; Dutman A; Koopmans M; Kooreman L; van der Vegt B; Verhoog L; Vreuls C; Westenend P; Kok M; van Diest PJ; Nauwelaers I; Laudus N; Denkert C; Rimm D; Siziopikou KP; Ely S; Zardavas D; Roberts M; Floris G; Hartman J; Acs B; Peeters D; Bartlett JMS; Dequeker E; Salgado R; Giudici F; Michiels S; Horlings H; van Deurzen CHM
Article: JAMA ONCOLOGY. 2021;7(9):1360-1367
Neoadjuvant Trastuzumab, Pertuzumab, and Docetaxel vs Trastuzumab Emtansine in Patients With ERBB2-Positive Breast Cancer A Phase 2 Randomized Clinical Trial
Hatschek T; Foukakis T; Bjohle J; Lekberg T; Fredholm H; Elinder E; Bosch A; Pekar G; Lindman H; Schiza A; Einbeigi Z; Adra J; Andersson A; Carlsson L; Dreifaldt AC; Isaksson-Friman E; Agartz S; Azavedo E; Gryback P; Hellstrom M; Johansson H; Maes C; Zerdes I; Hartman J; Brandberg Y; Bergh J
Article: ESMO OPEN. 2021;6(2):100076
bPrognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer
Matikas A; Wang K; Lagoudaki E; Acs B; Zerdes I; Hartman J; Azavedo E; Bjohle J; Carlsson L; Einbeigi Z; Hedenfalk I; Hellstrom M; Lekberg T; Loman N; Saracco A; von Wachenfeldt A; Rotstein S; Bergqvist M; Bergh J; Hatschek T; Foukakis T
Article: CANCERS. 2021;13(5):1166
Variability in Breast Cancer Biomarker Assessment and the Effect on Oncological Treatment Decisions: A Nationwide 5-Year Population-Based Study
Acs B; Fredriksson I; Ronnlund C; Hagerling C; Ehinger A; Kovacs A; Roge R; Bergh J; Hartman J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(10):e2017089118
TAp73 represses NF-κB-mediated recruitment of tumor-associated macrophages in breast cancer
Wolfsberger J; Sakil HAM; Zhou L; van Bree N; Baldisseri E; Ferreira SDS; Zubillaga V; Stantic M; Fritz N; Hartman J; Rolny C; Wilhelm MT
Article: BREAST CANCER RESEARCH. 2021;23(1):20
Molecular analyses of triple-negative breast cancer in the young and elderly
Aine M; Boyaci C; Hartman J; Hakkinen J; Mitra S; Campos AB; Nimeus E; Ehinger A; Vallon-Christersson J; Borg A; Staaf J
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1354
The Importance of Sex in the Discovery of Colorectal Cancer Prognostic Biomarkers
Hases L; Ibrahim A; Chen X; Liu Y; Hartman J; Williams C
Article: CANCER LETTERS. 2020;492:54-62
Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes
Hases L; Indukuri R; Birgersson M; Trang N-V; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-A; Katajisto P; Archer A; Williams C
Article: NATURE BIOMEDICAL ENGINEERING. 2020;4(9):875-888
Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies
Tanaka N; Kanatani S; Kaczynska D; Fukumoto K; Louhivuori L; Mizutani T; Kopper O; Kronqvist P; Robertson S; Lindh C; Kis L; Pronk R; Niwa N; Matsumoto K; Oya M; Miyakawa A; Falk A; Hartman J; Sahlgren C; Clevers H; Uhlen P
Article: BREAST CANCER RESEARCH AND TREATMENT. 2020;183(1):161-175
Prognostic potential of automated Ki67 evaluation in breast cancer: different hot spot definitions versus true global score
Robertson S; Acs B; Lippert M; Hartman J
Article: BREAST CANCER RESEARCH. 2020;22(1):80
Identification and targeting of selective vulnerability rendered by tamoxifen resistance
Singh M; Zhou X; Chen X; Santos GS; Peuget S; Cheng Q; Rihani A; Arner ESJ; Hartman J; Selivanova G
Article: NATURE COMMUNICATIONS. 2020;11(1):3747
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Glodzik D; Bosch A; Hartman J; Aine M; Vallon-Christersson J; Reutersward C; Karlsson A; Mitra S; Nimeus E; Holm K; Hakkinen J; Hegardt C; Saal LH; Larsson C; Malmberg M; Ryden L; Ehinger A; Loman N; Kvist A; Ehrencrona H; Nik-Zainal S; Borg A; Staaf J
Article: MOLECULAR ONCOLOGY. 2020;14(5):951-963
Programmed death-ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21-gene and 70-gene signatures in estrogen receptor-positive disease
Zerdes I; Sifakis EG; Matikas A; Chretien S; Tobin NP; Hartman J; Rassidakis GZ; Bergh J; Foukakis T
Article: CANCER RESEARCH. 2020;80(7):1538-1550
Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds
Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindstrom MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(3):1185-1198
CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment
Neo SY; Yang Y; Record J; Ma R; Chen X; Chen Z; Tobin NP; Blake E; Seitz C; Thomas R; Wagner AK; Andersson J; de Boniface J; Bergh J; Murray S; Alici E; Childs R; Johansson M; Westerberg LS; Haglund F; Hartman J; Lundqvist A
Article: SCIENTIFIC REPORTS. 2019;9(1):19384
CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance
Langeback A; Bacanu S; Laursen H; Mout L; Seki T; Erkens-Schulze S; Ramos AD; Berggren A; Cao Y; Hartman J; van Weerden W; Bergh J; Nordlund P; Loof S
Article: NATURE COMMUNICATIONS. 2019;10(1):4732
CUTseq is a versatile method for preparing multiplexed DNA sequencing libraries from low-input samples
Zhang X; Garnerone S; Simonetti M; Harbers L; Nicos M; Mirzazadeh R; Venesio T; Sapino A; Hartman J; Marchio C; Bienko M; Crosetto N
Article: NATURE COMMUNICATIONS. 2019;10(1):3589
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
Costa TDF; Zhuang T; Lorent J; Turco E; Olofsson H; Masia-Balague M; Zhao M; Rabieifar P; Robertson N; Kuiper R; Sjolund J; Spiess M; Hernandez-Varas P; Rabenhorst U; Roswall P; Ma R; Gong X; Hartman J; Pietras K; Adams PD; Defilippi P; Stromblad S
Article: NATURE COMMUNICATIONS. 2019;10(1):2110
Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
Prakash V; Carson BB; Feenstra JM; Dass RA; Sekyrova P; Hoshino A; Petersen J; Guo Y; Parks MM; Kurylo CM; Batchelder JE; Haller K; Hashimoto A; Rundqivst H; Condeelis JS; Allis CD; Drygin D; Nieto MA; Andang M; Percipalle P; Bergh J; Adameyko I; Farrants A-KO; Hartman J; Lyden D; Pietras K; Blanchard SC; Vincent CT
Article: BREAST CANCER RESEARCH AND TREATMENT. 2019;174(3):795-805
Re-testing of predictive biomarkers on surgical breast cancer specimens is clinically relevant
Robertson S; Ronnlund C; de Boniface J; Hartman J
Article: BREAST CANCER RESEARCH AND TREATMENT. 2018;172(3):703-712
Prognosis in patients diagnosed with loco-regional failure of breast cancer: 34years longitudinal data from the Stockholm-Gotland cancer registry
Falato C; Taylor SK; Szulkin R; Nordblom A; Eriksson L; Sofiadis A; Fredriksson I; Hartman J; Bergh J; Foukakis T
Article: ONCOGENE. 2018;37(46):6083-6095
Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types
Mutvei AP; Landor SK-J; Fox R; Braune E-B; Tsoi YL; Phoon YP; Sahlgren C; Hartman J; Bergh J; Jin S; Lendahl U
Article: JOURNAL OF TRAUMA AND ACUTE CARE SURGERY. 2018;85(4):717-724
Abdominal Aortic and Junctional Tourniquet release after 240 minutes is survivable and associated with small intestine and liver ischemia after porcine class II hemorrhage
Brannstrom A; Rocksen D; Hartman J; Nyman N; Gustavsson J; Arborelius UP; Gunther M
Article: JOURNAL OF CLINICAL PATHOLOGY. 2018;71(9):787-794
Prognostic value of Ki67 analysed by cytology or histology in primary breast cancer
Robertson S; Stalhammar G; Darai-Ramqvist E; Rantalainen M; Tobin NP; Bergh J; Hartman J
Article: CELL. 2018;173(4):879-893.e13
Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing
Kim C; Gao R; Sei E; Brandt R; Hartman J; Hatschek T; Crosetto N; Foukakis T; Navin NE
Article: HISTOPATHOLOGY. 2018;72(6):974-989
Digital image analysis of Ki67 in hot spots is superior to both manual Ki67 and mitotic counts in breast cancer
Stalhammar G; Robertson S; Wedlund L; Lippert M; Rantalainen M; Bergh J; Hartman J
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(4):1355-1370
Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes
Ullah I; Karthik G-M; Alkodsi A; Kjallquist U; Stalhammar G; Lovrot J; Martinez N-F; Lagergren J; Hautaniemi S; Hartman J; Bergh J
Article: BMC CANCER. 2018;18(1):174
Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)
Kjallquist U; Erlandsson R; Tobin NP; Alkodsi A; Ullah I; Stalhammar G; Karlsson E; Hatschek T; Hartman J; Linnarsson S; Bergh J
Article: BMC CANCER. 2017;17(1):802
Intra-tumor heterogeneity in breast cancer has limited impact on transcriptomic-based molecular profiling
Karthik G-M; Rantalainen M; Stalhammar G; Lovrot J; Ullah I; Alkodsi A; Ma R; Wedlund L; Lindberg J; Frisell J; Bergh J; Hartman J
Article: NATURE BIOMEDICAL ENGINEERING. 2017;1(10):796-806
Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity
Tanaka N; Kanatani S; Tomer R; Sahlgren C; Kronqvist P; Kaczynska D; Louhivuori L; Kis L; Lindh C; Mitura P; Stepulak A; Corvigno S; Hartman J; Micke P; Mezheyeuski A; Strell C; Carlson JW; Moro CF; Dahlstrand H; Ostman A; Matsumoto K; Wiklund P; Oya M; Miyakawa A; Deisseroth K; Uhlen P
Journal article: ANNALS OF ONCOLOGY. 2017;28:v95
288P Prognosis after loco-regional recurrence of breast cancer: 35 years longitudinal data from the Stockholm cancer register
Falato C; Eriksson L; Sofiadis A; Taylor SK; Nordblom A; Fredriksson I; Hartman J; Bergh J; Foukakis T
Article: CLINICAL CANCER RESEARCH. 2017;23(16):4769-4779
A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis
Liu C; Zhang Y; Lim S; Hosaka K; Yang Y; Pavlova T; Alkasalias T; Hartman J; Jensen L; Xing X; Wang X; Lu Y; Nie G; Cao Y
Article: CLINICAL CANCER RESEARCH. 2017;23(10):2584-2592
Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes
Li J; Ivansson E; Klevebring D; Tobin NP; Lindstrom LS; Holm J; Prochazka G; Cristando C; Palmgren J; Tornberg S; Humphreys K; Hartman J; Frisell J; Rantalainen M; Lindberg J; Hall P; Bergh J; Gronberg H; Czene K
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2017;109(3):1-14
Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells
Ma R; Karthik G-M; Lovrot J; Haglund F; Rosin G; Katchy A; Zhang X; Viberg L; Frisell J; Williams C; Linder S; Fredriksson I; Hartman J
Article: MATURITAS. 2017;96:39-44
Differential expression of sex hormone receptors in abdominal aortic aneurysms
Villard C; Eriksson P; Kronqvist M; Lengquist M; Jorns C; Hartman J; Roy J; Hultgren R
Article: SCIENTIFIC REPORTS. 2016;6:38037
Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers.
Rantalainen M; Klevebring D; Lindberg J; Ivansson E; Rosin G; Kis L; Celebioglu F; Fredriksson I; Czene K; Frisell J; Hartman J; Bergh J; Grönberg H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(38):E5618-E5627
Pericyte-fibroblast transition promotes tumor growth and metastasis
Hosaka K; Yang Y; Seki T; Fischer C; Dubey O; Fredlund E; Hartman J; Religa P; Morikawa H; Ishii Y; Sasahara M; Larsson O; Cossu G; Cao R; Lim S; Cao Y
Article: ONCOTARGET. 2016;7(24):35703-35723
Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells
Pellegrini P; Dyczynski M; Sbrana FV; Karlgren M; Buoncervello M; Hagg-Olofsson M; Ma R; Hartman J; Bajalica-Lagercrantz S; Grander D; Kharaziha P; De Milito A
Article: CANCER RESEARCH. 2016;76(11):3166-3178
Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages
Wallerius M; Wallmann T; Bartish M; Ostling J; Mezheyeuski A; Tobin NP; Nygren E; Pangigadde P; Pellegrini P; Squadrito ML; Ponten F; Hartman J; Bergh J; DeMilito A; De Palma M; Ostman A; Andersson J; Rolny C
Article: MODERN PATHOLOGY. 2016;29(4):318-329
Digital image analysis outperforms manual biomarker assessment in breast cancer
Stalhammar G; Martinez NF; Lippert M; Tobin NP; Molholm I; Kis L; Rosin G; Rantalainen M; Pedersen L; Bergh J; Grunkin M; Hartman J
Journal article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2016;108(3)
Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells (vol 107, djv209, 2015)
Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: CANCER LETTERS. 2015;367(1):76-87
mTOR inhibitors counteract tamoxifen-induced activation of breast cancer stem cells
Karthik G-M; Ma R; Lovrot J; Kis LL; Lindh C; Blomquist L; Fredriksson I; Bergh J; Hartman J
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(10):djv209
Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells
Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: ANNALS OF DIAGNOSTIC PATHOLOGY. 2015;19(4):203-210
Gene protein detection platform-a comparison of a new human epidermal growth factor receptor 2 assay with conventional immunohistochemistry and fluorescence in situ hybridization platforms
Stalhammar G; Farrajota P; Olsson A; Silva C; Hartman J; Elmberger G
Article: ENDOCRINE CONNECTIONS. 2015;4(1):76-85
Tumour nuclear oestrogen receptor beta 1 correlates inversely with parathyroid tumour weight
Haglund F; Rosin G; Nilsson I-L; Juhlin CC; Pernow Y; Norenstedt S; Dinets A; Larsson C; Hartman J; Hoog A
Article: CANCER RESEARCH. 2015;75(2):306-315
Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development
Wang J; Cao Z; Zhang X-M; Nakamura M; Sun M; Hartman J; Harris RA; Sun Y; Cao Y
Article: MOLECULAR ONCOLOGY. 2014;8(8):1690-1702
miR-206 inhibits cell migration through direct targeting of the actin-binding protein Coronin 1C in triple-negative breast cancer
Wang J; Tsouko E; Jonsson P; Bergh J; Hartman J; Aydogdu E; Williams C
Article: BRITISH JOURNAL OF CANCER. 2014;111(5):918-926
Oestrogen receptors β1 and βcx have divergent roles in breast cancer survival and lymph node metastasis
Rosin G; de Boniface J; Karthik GM; Frisell J; Bergh J; Hartman J
Article: NATURE COMMUNICATIONS. 2014;5:4557
AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion
Mojallal M; Zheng Y; Hultin S; Audebert S; van Harn T; Johnsson P; Lenander C; Fritz N; Mieth C; Corcoran M; Lembo F; Hallstroem M; Hartman J; Mazure NM; Weide T; Grander D; Borg J-P; Uhlen P; Holmgren L
Article: BREAST CANCER RESEARCH. 2014;16(4):R72
Sequencing of breast cancer stem cell populations indicates a dynamic conversion between differentiation states in vivo
Klevebring D; Rosin G; Ma R; Lindberg J; Czene K; Kere J; Fredriksson I; Bergh J; Hartman J
Article: LABORATORY INVESTIGATION. 2014;94(7):796-805
Superficial scrapings from breast tumors is a source for biobanking and research purposes
Ma R; Fredriksson I; Karthik G-M; Winn G; Darai-Ramqvist E; Bergh J; Hartman J
Article: HISTOPATHOLOGY. 2014;64(7):971-980
Low concordance of biomarkers in histopathological and cytological material from breast cancer
Stalhammar G; Rosin G; Fredriksson I; Bergh J; Hartman J
Article: VIRCHOWS ARCHIV. 2013;463(5):637-642
Lymphoid aggregates in Crohn's colitis and mucosal immunity
Rubio CA; Asmundsson J; Silva P; Illies C; Hartman J; Kis L
Article: PLOS ONE. 2013;8(2):e56795
High Prevalence of Human Cytomegalovirus Proteins and Nucleic Acids in Primary Breast Cancer and Metastatic Sentinel Lymph Nodes
Taher C; de Boniface J; Mohammad A-A; Religa P; Hartman J; Yaiw K-C; Frisell J; Rahbar A; Soderberg-Naucler C
Article: MOLECULAR ENDOCRINOLOGY. 2012;26(12):1991-2003
Estrogen Receptors β1 and β2 Have Opposing Roles in Regulating Proliferation and Bone Metastasis Genes in the Prostate Cancer Cell Line PC3
Dey P; Jonsson P; Hartman J; Williams C; Stroem A; Gustafsson J-A
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2012;97(12):4631-4639
Evidence of a Functional Estrogen Receptor in Parathyroid Adenomas
Haglund F; Ma R; Huss M; Sulaiman L; Lu M; Nilsson I-L; Hoog A; Juhlin CC; Hartman J; Larsson C
Article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(21):2601-2608
Clinically Used Breast Cancer Markers Such As Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 Are Unstable Throughout Tumor Progression
Lindstrom LS; Karlsson E; Wilking UM; Johansson U; Hartman J; Lidbrink EK; Hatschek T; Skoog L; Bergh J
Article: BMC CANCER. 2012;12:79
The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer
Rosin G; Hannelius U; Lindstrom L; Hall P; Bergh J; Hartman J; Kere J
Article: AMERICAN JOURNAL OF PATHOLOGY. 2011;179(3):1148-1156
ERβ1 Represses FOXM1 Expression through Targeting ERα to Control Cell Proliferation in Breast Cancer
Horimoto Y; Hartman J; Millour J; Pollock S; Olmos Y; Ho K-K; Coombes RC; Poutanen M; Makela SI; El-Bahrawy M; Speirs V; Lam EW-F
Article: ONCOGENE. 2010;29(20):2983-2995
FOXM1 is a transcriptional target of ERα and has a critical role in breast cancer endocrine sensitivity and resistance
Millour J; Constantinidou D; Stavropoulou AV; Wilson MSC; Myatt SS; Kwok JM-M; Sivanandan K; Coombes RC; Medema RH; Hartman J; Lykkesfeldt AE; Lam EW-F
Article: CANCER RESEARCH. 2009;69(15):6100-6106
Tumor Repressive Functions of Estrogen Receptor β in SW480 Colon Cancer Cells
Hartman J; Edvardsson K; Lindberg K; Zhao C; Williams C; Strom A; Gustafsson J-A
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2009;35(1):57-68
FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer
Francis RE; Myatt SS; Krol J; Hartman J; Peck B; McGovern UB; Wang J; Guest SK; Filipovic A; Gojis O; Palmieri C; Peston D; Shousha S; Yu Q; Sicinski P; Coombes RC; Lam EW-F
Article: BREAST CANCER RESEARCH. 2009;11(6):R79
Hes-6, an inhibitor of Hes-1, is regulated by 17β-estradiol and promotes breast cancer cell proliferation
Hartman J; Lam EW-F; Gustafsson J-A; Strom A
Article: CANCER RESEARCH. 2006;66(23):11207-11213
Estrogen receptor β inhibits angiogenesis and growth of T47D breast cancer xenografts
Hartman J; Lindberg K; Morani A; Inzunza J; Strom A; Gustafsson J-A
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2006;24(18_suppl):10101
Estrogen receptor β represses breast tumor growth and angiogenesis in vivo
Hartman J; Lindberg K; Inzunza J; Wan J; Ström A; Gustafsson J
Article: BRITISH JOURNAL OF NUTRITION. 2005;94(5):623-632
The case for strategic international alliances to harness nutritional genomics for public and personal health
Kaput J; Ordovas JM; Ferguson L; van Ommen B; Rodriguez RL; Allen L; Ames BN; Dawson K; German B; Krauss R; Malyj W; Archer MC; Barnes S; Bartholomew A; Birk R; van Bladeren P; Bradford KJ; Brown KH; Caetano R; Castle D; Chadwick R; Clarke S; Clément K; Cooney CA; Corella D; da Cruz IBM; Daniel H; Duster T; Ebbesson SOE; Elliott R; Fairweather-Tait S; Felton J; Fenech M; Finley JW; Fogg-Johnson N; Gill-Garrison R; Gibney MJ; Gillies PJ; Gustafsson J; Hartmann JL; He L; Hwang JK; Jais JP; Jang YS; Joost H; Junien C; Kanter M; Kibbe WA; Koletzko B; Korf BR; Kornman K; Krempin DW; Langin D; Lauren DR; Lee JH; Leveille GA; Lin SJ; Mathers J; Mayne M; McNabb W; Milner JA; Morgan P; Muller M; Nikolsky Y; van der Ouderaa F; Park T; Pensel N; Perez-Jimenez F; Poutanen K; Roberts M; Saris WHM; Schuster G; Shelling AN; Simopoulos AP; Southon S; Tai ES; Towne B; Trayhurn P; Uauy R; Visek WJ; Warden C; Weiss R; Wiencke J; Winkler J; Wolff GL; Xi ZW; Zucker JD
Article: ONCOGENE. 2004;23(54):8826-8833
HES-1 inhibits 17β-estradiol and heregulin-β1-mediated upregulation of E2F-1
Hartman J; Müller P; Foster JS; Wimalasena J; Gustafsson J; Ström A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(6):1566-1571
Estrogen receptor β inhibits 17β-estradiol-stimulated proliferation of the breast cancer cell line T47D
Ström A; Hartman J; Foster JS; Kietz S; Wimalasena J; Gustafsson JA
Article: JOURNAL OF ENDOCRINOLOGY. 2001;171(3):R11-R15
Lithium chloride inhibits the expression and secretion of insulin-like growth factor-binding protein-1
Lewitt MS; Brismar K; Ohlson J; Hartman J
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Conference publication: CANCER RESEARCH. 2024;84(9):po4-01-05-po4-01-05
The prognostic importance of biological pathway enrichment patterns in trastuzumab-treated early HER2-positive breast cancer
Ronnlund C; Yang Q; Schagerholm C; Foukakis T; Fredriksson I; Chen X; Robertson S; Sifakis E; Hartman J
Review: JOURNAL OF PATHOLOGY. 2024;262(3):271-288
Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer
Jahangir CA; Page DB; Broeckx G; Gonzalez CA; Burke C; Murphy C; Reis-Filho JS; Ly A; Harms PW; Gupta RR; Vieth M; Hida AI; Kahila M; Kos Z; van Diest PJ; Verbandt S; Thagaard J; Khiroya R; Abduljabbar K; Haab GA; Acs B; Adams S; Almeida JS; Alvarado-Cabrero I; Azmoudeh-Ardalan F; Badve S; Baharun NB; Bellolio ER; Bheemaraju V; Blenman KRM; Fujimoto LBM; Burgues O; Chardas A; Cheang MCU; Ciompi F; Cooper LAD; Coosemans A; Corredor G; Portela FLD; Deman F; Demaria S; Dudgeon SN; Elghazawy M; Fernandez-Martin C; Fineberg S; Fox SB; Giltnane JM; Gnjatic S; Gonzalez-Ericsson PI; Grigoriadis A; Halama N; Hanna MG; Harbhajanka A; Hart SN; Hartman J; Hewitt S; Horlings HM; Husain Z; Irshad S; Janssen EAM; Kataoka TR; Kawaguchi K; Khramtsov AI; Kiraz U; Kirtani P; Kodach LL; Korski K; Akturk G; Scott E; Kovacs A; Laenkholm A-V; Lang-Schwarz C; Larsimont D; Lennerz JK; Lerousseau M; Li X; Madabhushi A; Maley SK; Narasimhamurthy VM; Marks DK; McDonald ES; Mehrotra R; Michiels S; Kharidehal D; Minhas FUAA; Mittal S; Moore DA; Mushtaq S; Nighat H; Papathomas T; Penault-Llorca F; Perera RD; Pinard CJ; Pinto-Cardenas JC; Pruneri G; Pusztai L; Rajpoot NM; Rapoport BL; Rau TT; Ribeiro JM; Rimm D; Vincent-Salomon A; Saltz J; Sayed S; Hytopoulos E; Mahon S; Siziopikou KP; Sotiriou C; Stenzinger A; Sughayer MA; Sur D; Symmans F; Tanaka S; Taxter T; Tejpar S; Teuwen J; Thompson EA; Tramm T; Tran WT; van Der Laak J; Verghese GE; Viale G; Wahab N; Walter T; Waumans Y; Wen HY; Yang W; Yuan Y; Bartlett J; Loibl S; Denkert C; Savas P; Loi S; Stovgaard ES; Salgado R; Gallagher WM; Rahman A
Preprint: BIORXIV. 2024
Prelude to Malignancy: A Gene Expression Signature in Normal Mammary Gland from Breast Cancer Patients Suggests Pre-tumorous Alterations and Is Associated with Adverse Outcomes
Andreou M; Jąkalski M; Duzowska K; Filipowicz N; Kostecka A; Davies H; Horbacz M; Ławrynowicz U; Chojnowska K; Bruhn-Olszewska B; Jankau J; Śrutek E; Las-Jankowska M; Bała D; Hoffman J; Hartman J; Pęksa R; Skokowski J; Jankowski M; Szylberg Ł; Zegarski W; Nowikiewicz M; Nowikiewicz T; Dumanski JP; Mieczkowski J; Piotrowski A
Preprint: RESEARCH SQUARE. 2023
Clinical evaluation of deep learning-based risk profiling in breast cancer histopathology and comparison to an established multigene assay
Robertson S; Wang Y; Sun W; Karlsson E; Lövgren SK; Acs B; Rantalainen M; Hartman J
Preprint: MEDRXIV. 2023
Validation of an AI-based solution for breast cancer risk stratification using routine digital histopathology images
Sharma A; Lövgren SK; Eriksson KL; Wang Y; Robertson S; Hartman J; Rantalainen M
Preprint: MEDRXIV. 2023
Clinical evaluation of deep learning-based risk profiling in breast cancer histopathology and comparison to an established multigene assay
Wang Y; Sun W; Karlsson E; Lövgren SK; Ács B; Rantalainen M; Rantalainen M; Robertson S; Hartman J
Preprint: MEDRXIV. 2023
Deep learning-based risk stratification of preoperative breast biopsies using digital whole slide images
Boissin C; Wang Y; Sharma A; Weitz P; Karlsson E; Robertson S; Hartman J; Rantalainen M
Review: JOURNAL OF PATHOLOGY. 2023;260(5):498-513
Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer: a report of the international immuno-oncology biomarker working group
Thagaard J; Broeckx G; Page DB; Jahangir CA; Verbandt S; Kos Z; Gupta R; Khiroya R; Abduljabbar K; Acosta Haab G; Acs B; Akturk G; Almeida JS; Alvarado-Cabrero I; Amgad M; Azmoudeh-Ardalan F; Badve S; Baharun NB; Balslev E; Bellolio ER; Bheemaraju V; Blenman KRM; Botinelly Mendonca Fujimoto L; Bouchmaa N; Burgues O; Chardas A; Cheang MU; Ciompi F; Cooper LAD; Coosemans A; Corredor G; Dahl AB; Dantas Portela FL; Deman F; Demaria S; Dore Hansen J; Dudgeon SN; Ebstrup T; Elghazawy M; Fernandez-Martin C; Fox SB; Gallagher WM; Giltnane JM; Gnjatic S; Gonzalez-Ericsson PI; Grigoriadis A; Halama N; Hanna MG; Harbhajanka A; Hart SN; Hartman J; Hauberg S; Hewitt S; Hida AI; Horlings HM; Husain Z; Hytopoulos E; Irshad S; Janssen EAM; Kahila M; Kataoka TR; Kawaguchi K; Kharidehal D; Khramtsov AI; Kiraz U; Kirtani P; Kodach LL; Korski K; Kovacs A; Laenkholm A-V; Lang-Schwarz C; Larsimont D; Lennerz JK; Lerousseau M; Li X; Ly A; Madabhushi A; Maley SK; Manur Narasimhamurthy V; Marks DK; McDonald ES; Mehrotra R; Michiels S; Minhas FUAA; Mittal S; Moore DA; Mushtaq S; Nighat H; Papathomas T; Penault-Llorca F; Perera RD; Pinard CJ; Pinto-Cardenas JC; Pruneri G; Pusztai L; Rahman A; Rajpoot NM; Rapoport BL; Rau TT; Reis-Filho JS; Ribeiro JM; Rimm D; Roslind A; Vincent-Salomon A; Salto-Tellez M; Saltz J; Sayed S; Scott E; Siziopikou KP; Sotiriou C; Stenzinger A; Sughayer MA; Sur D; Fineberg S; Symmans F; Tanaka S; Taxter T; Tejpar S; Teuwen J; Thompson EA; Tramm T; Tran WT; van Der Laak J; van Diest PJ; Verghese GE; Viale G; Vieth M; Wahab N; Walter T; Waumans Y; Wen HY; Yang W; Yuan Y; Zin RM; Adams S; Bartlett J; Loibl S; Denkert C; Savas P; Loi S; Salgado R; Specht Stovgaard E
Review: JOURNAL OF PATHOLOGY. 2023;260(5):514-532
Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer
Page DB; Broeckx G; Jahangir CA; Jahangir C; Verbandt S; Gupta RR; Thagaard J; Khiroya R; Kos Z; Abduljabbar K; Acosta Haab G; Acs B; Almeida JS; Alvarado-Cabrero I; Azmoudeh-Ardalan F; Badve S; Baharun NB; Bellolio ER; Bheemaraju V; Blenman KRM; Botinelly Mendonca Fujimoto L; Burgues O; Cheang MCU; Ciompi F; Cooper LAD; Coosemans A; Corredor G; Dantas Portela FL; Deman F; Demaria S; Dudgeon SN; Elghazawy M; Ely S; Fernandez-Martin C; Fineberg S; Fox SB; Gallagher WM; Giltnane JM; Gnjatic S; Gonzalez-Ericsson PI; Grigoriadis A; Halama N; Hanna MG; Harbhajanka A; Hardas A; Hart SN; Hartman J; Hewitt S; Hida AI; Horlings HM; Husain Z; Hytopoulos E; Irshad S; Janssen EAM; Kahila M; Kataoka TR; Kawaguchi K; Kharidehal D; Khramtsov AI; Kiraz U; Kirtani P; Kodach LL; Korski K; Kovacs A; Laenkholm A-V; Lang-Schwarz C; Larsimont D; Lennerz JK; Lerousseau M; Li X; Ly A; Madabhushi A; Maley SK; Manur Narasimhamurthy V; Marks DK; McDonald ES; Mehrotra R; Michiels S; Minhas FUAA; Mittal S; Moore DA; Mushtaq S; Nighat H; Papathomas T; Penault-Llorca F; Perera RD; Pinard CJ; Pinto-Cardenas JC; Pruneri G; Pusztai L; Rahman A; Rajpoot NM; Rapoport BL; Rau TT; Reis-Filho JS; Ribeiro JM; Rimm D; Salomon A-V; Salto-Tellez M; Saltz J; Sayed S; Siziopikou KP; Sotiriou C; Stenzinger A; Sughayer MA; Sur D; Symmans F; Tanaka S; Taxter T; Tejpar S; Teuwen J; Thompson EA; Tramm T; Tran WT; van Der Laak J; van Diest PJ; Verghese GE; Viale G; Vieth M; Wahab N; Walter T; Waumans Y; Wen HY; Yang W; Yuan Y; Adams S; Bartlett JMS; Loibl S; Denkert C; Savas P; Loi S; Salgado R; Specht Stovgaard E; Akturk G; Bouchmaa N
Preprint: ARXIV. 2023
Increasing the usefulness of already existing annotations through WSI registration
Weitz P; Sartor V; Acs B; Robertson S; Budelmann D; Hartman J; Rantalainen M
Meeting abstract: CANCER RESEARCH. 2023;83(5):p2-21-02-p2-21-02
Longitudinal tumor-immune microenvironment changes in patients with clinical luminal A early breast cancer treated with neoadjuvant palbociclib and endocrine therapy: results from the Swedish randomized PREDIX Luminal A trial
Zerdes I; Salgkamis D; Matikas A; Selander L; Wang K; Tzoras E; Sifakis E; Agartz S; Chen X; Hellstrom M; Hartman J; Bergh J; Foukakis T; Hatschek T
Meeting abstract: CANCER RESEARCH. 2023;83(5):p5-02-20-p5-02-20
Correlative and longitudinal transcriptomic profiling predicts patient outcomes and the efficacy of neoadjuvant HER2-targeted treatments in the randomized PREDIX HER2 trial
Wang K; Zhu Y; Zerdes I; Matikas A; Sifakis E; Salgkamis D; Bjohle J; Elinder E; Margolin S; Campos AB; Pekar G; Lindman H; Schiza A; Einbeigi Z; Adra J; Andersson A; Carlsson L; Dreifaldt AC; Isaksson-Friman E; Agartz S; Johansson H; Hellstrom M; Azavedo E; Hartman J; Bergh J; Hatschek T; Foukakis T
Preprint: MEDRXIV. 2023
Development and prognostic validation of a three-level NHG-like deep learning-based model for histological grading of breast cancer
Sharma A; Weitz P; Wang Y; Liu B; Hartman J; Rantalainen M
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33(7):S614
The prognostic importance of high HER2 copy numbers and high HER2/CEP17 ratio in trastuzumab-treated early breast cancer
Ronnlund C; Robertson S; Sifakis EG; Fredriksson I; Foukakis T; Hartman J
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33(7):S640
Gene expression profiles in endocrine-resistant breast cancer
Schagerholm C; Robertson S; Sifakis EG; Hases L; Williams C; Hartman J
Editorial comment: CANCERS. 2022;14(15):3762
External Quality Assessment 2.0: The Importance of a Standardized Implementation of TILs for Daily and Trial Practices
Nauwelaers I; Laudus N; Peeters D; Acs B; Denkert C; Michiels S; Horlings H; Siziopikou KP; Ely S; Zardavas D; Mustimbo R; Bartlett J; Floris G; Hartman J; van Deurzen CHM; Ceusters D; Dequeker E; Salgado R
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(16_suppl):593
Combined assessment of metabolic response and tumor infiltrating lymphocytes as a predictor of outcomes following neoadjuvant therapy for HER2-positive breast cancer: Results from the randomized PREDIX HER2 trial.
Matikas A; Johansson H; Grybäck P; Bjöhle J; Lekberg T; Fredholm H; Acs B; Elinder E; Isaksson-Friman E; Agartz S; Hellstrom M; Zerdes I; Hartman J; Bergh JCS; Hatschek T; Foukakis T
Meeting abstract: CANCER RESEARCH. 2022;82(4):p1-02-03-p1-02-03
Tumor-infiltrating lymphocytes but not HER2 copy number or ratio show prognostic value in trastuzumab-treated HER2-positive breast cancer
Robertson S; Ronnlund C; Fredriksson I; Foukakis T; Hartman J
Conference publication: CANCER RESEARCH. 2022;82(4):p3-02-06-p3-02-06
A phase II study of ⁶⁸Ga-ABY-025 PET for non-invasive quantification of HER2 expression in breast cancer
Alhuseinalkhudhur A; Lindman H; Liss P; Sundin T; Frejd FY; Hartman J; Iyer V; Lubberink M; Velikyan I; Sorensen J
Meeting abstract: CANCER RESEARCH. 2022;82(4):p1-07-07-p1-07-07
Endoresist: Prognostic and predictive gene profiles in endocrine-resistant breast cancers
Schagerholm C; Robertson S; Holm B; Lindberg K; Sifakis E; Hases L; Williams C; Hartman J
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(16)
Combined assessment of metabolic response and tumor infiltrating lymphocytes as a predictor of outcomes following neoadjuvant therapy for HER2-positive breast cancer: Results from the randomized PREDIX HER2 trial.
Matikas A; Johansson H; Gryback P; Bjohle J; Lekberg T; Fredholm H; Acs B; Elinder E; Isaksson-Friman E; Agartz S; Hellstrom M; Zerdes I; Hartman J; Bergh JCS; Hatschek T; Foukakis T
Conference publication: VIRCHOWS ARCHIV. 2022;481(SUPPL 1):S42-S43
PIK3CA mutations in endocrine-resistant breast cancer
Schagerholm C; Robertson S; Holm B; Awier H; Toosi H; Sifakis E; Hartman J
Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(46):e2117333118
TAp73 represses NF-κB-mediated recruitment of tumor-associated macrophages in breast cancer (vol 118, e2017089118, 2021)
Wolfsberger J; Sakil HAM; Zhou L; van Bree N; Baldisseri E; Ferreira SDS; Zubillaga V; Stantic M; Fritz N; Hartman J; Rolny C; Wilhelm MT
Editorial comment: EBIOMEDICINE. 2021;70:103520
What do we still need to learn on digitally assessed biomarkers?
Acs B; Salgado R; Hartman J
Corrigendum: BREAST CANCER RESEARCH. 2021;23(1):28
Molecular analyses of triple-negative breast cancer in the young and elderly (vol 23, 20, 2021)
Aine M; Boyaci C; Hartman J; Hakkinen J; Mitra S; Campos AB; Nimeus E; Ehinger A; Vallon-Christersson J; Borg A; Staaf J
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2021;48(SUPPL 1):S300
⁶⁸Ga-ABY-025 PET Predicts the Metabolic Response in Breast Cancer Patients: Preliminary Results From a Phase II Study
Alhuseinalkhudhur A; Lindman H; Lubberink M; Iyer V; Liss P; Sundin T; Frejd FY; Hartman J; Velikyan I; Sorensen J
Conference publication: CANCER RESEARCH. 2021;81(4)
Integrated immuno-genomic analyses in early breast cancer: Results from the Scandinavian breast group 2004-1 (SBG-2004-1) randomized phase II trial
Zerdes I; Simonetti M; Matikas A; Harbers L; Zhang N; Salgkamis D; Agartz S; Zacharouli M; Moreno-Ruiz P; Hartman J; Mezheyeuski A; Bergh J; Crosetto N; Foukakis T
Conference publication: CANCER RESEARCH. 2020;80(16):2081
Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes
Hases L; Indukuri R; Birgersson M; Trang N-V; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-A; Katajisto P; Archer A; Williams C
Review: JOURNAL OF INTERNAL MEDICINE. 2020;288(1):62-81
Artificial intelligence as the next step towards precision pathology
Acs B; Rantalainen M; Hartman J
Letter: NATURE MEDICINE. 2020;26(7):992-994
Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal
Tamborero D; Dienstmann R; Rachid MH; Boekel J; Baird R; Brana I; De Petris L; Yachnin J; Massard C; Opdam FL; Schlenk R; Vernieri C; Garralda E; Masucci M; Villalobos X; Chavarria E; Calvo F; Frohling S; Eggermont A; Apolone G; Voest EE; Caldas C; Tabernero J; Ernberg I; Rodon J; Lehtio J
Meeting abstract: ANNALS OF ONCOLOGY. 2020;31:S49
PREDIX HER2 trial: Event-free survival and pathologic complete response in clinical subgroups and stromal TILs levels
Hatschek T; Andersson A; Bjohle J; Bosch A; Carlsson L; Dreifaldt AC; Einbeigi Z; Elinder E; Fredholm H; Isaksson-Friman E; Hellstrom M; Johansson H; Lekberg T; Lindman H; Zerdes I; Foukakis T; Hartman J; Brandberg Y; Bergh J
Meeting abstract: CANCER RESEARCH. 2020;80(4):p5-02-07-p5-02-07
Distribution of biomarker evaluation scores among the pathology departments of Sweden: Comparison study of 35,066 breast cancer cases
Acs B; Fredriksson I; Wilking U; Robertson S; Hartman J
Conference publication: CANCER RESEARCH. 2020;80(4):p5-02-01-p5-02-01
Analytical validation and prognostic potential of an automated digital scoring protocol for Ki67: An International Ki67 Working Group study
Acs B; Leung SCY; Kidwell KM; Arun I; Augulis R; Badve SS; Bai Y; Bane AL; Bartlett JMS; Bayani J; Bigras G; Blank A; Borgquist S; Buikema H; Chang MC; Dietz RL; Dodson A; Ehinger A; Fineberg S; Focke CM; Gao D; Gown AM; Gutierrez C; Hartman J; Hugh JC; Kos Z; Laenkholm A-V; Laurinavicius A; Levenson RM; Mahboubi-Ardakani R; Mastropasqua MG; Moriya T; Nofech-Mozes S; Osborne CK; Pantanowitz L; Penault-Llorca FM; Piper T; Quintayo MA; Rau TT; Reinhard S; Robertson S; Sakatani T; Salgado R; Spears M; Tarczynski JS; Sugie T; van der Vegt B; Viale G; Virk S; Zabaglo LA; Hayes DF; Dowsett M; Nielsen TO; Rimm DL
Conference publication: CANCER RESEARCH. 2020;80(4):p5-02-06-p5-02-06
Improved histologic grading of breast cancer by a novel deep learning-based model
Rantalainen M; Wang Y; Acz B; Robertson S; Hartman J
Conference publication: CANCER RESEARCH. 2020;80(4):p3-08-19-p3-08-19
Biomarkers associated with dcis related breast cancer death
Wadsten C; Hartman J; Fredriksson I; Garmo H; Warnberg F; Sund M
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2020;38(15)
PREDIX II HER2: Improving pre-operative systemic therapy for human epidermal growth factor receptor 2 (HER2) amplified breast cancer (BC).
Kornalijnslijper-Altena R; Andersson A; Brandberg Y; Kessler LE; Elinder E; Hartman J; Hellstrom M; Johansson H; Killander F; Linderholm BK; Lindman H; Valachis A; Wennstig AK; Xie H; Hatschek T; Bergh JCS
Review: NPJ BREAST CANCER. 2020;6(1):16
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
Amgad M; Stovgaard ES; Balslev E; Thagaard J; Chen W; Dudgeon S; Sharma A; Kerner JK; Denkert C; Yuan Y; AbdulJabbar K; Wienert S; Savas P; Voorwerk L; Beck AH; Madabhushi A; Hartman J; Sebastian MM; Horlings HM; Hudecek J; Ciompi F; Moore DA; Singh R; Roblin E; Balancin ML; Mathieu M-C; Lennerz JK; Kirtani P; Chen I-C; Braybrooke JP; Pruneri G; Demaria S; Adams S; Schnitt SJ; Lakhani SR; Rojo F; Comerma L; Badve SS; Khojasteh M; Symmans WF; Sotiriou C; Gonzalez-Ericsson P; Pogue-Geile KL; Kim RS; Rimm DL; Viale G; Hewitt SM; Bartlett JMS; Penault-Llorca F; Goel S; Lien H-C; Loibl S; Kos Z; Loi S; Hanna MG; Michiels S; Kok M; Nielsen TO; Lazar AJ; Bago-Horvath Z; Kooreman LFS; van der Laak JAWM; Saltz J; Gallas BD; Kurkure U; Barnes M; Salgado R; Cooper LAD
Editorial comment: JOURNAL OF PATHOLOGY. 2020;250(1):7-8
Next generation pathology: artificial intelligence enhances histopathology practice
Acs B; Hartman J
Review: TRANSLATIONAL RESEARCH. 2018;194:19-35
Digital image analysis in breast pathology-from image processing techniques to artificial intelligence
Robertson S; Azizpour H; Smith K; Hartman J
Conference publication: EUROPEAN JOURNAL OF CANCER. 2018;92:S67-S68
Biomarkers in DCIS associated with breast cancer death
Wadsten C; Warnberg F; Tolockiene E; Hartman J; Fredriksson I; Garmo H; Sund M
Corrigendum: NATURE BIOMEDICAL ENGINEERING. 2018;2(1):48
Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity (vol 1, pg 796, 2017)
Tanaka N; Kanatani S; Tomer R; Sahlgren C; Kronqvist P; Kaczynska D; Louhivuori L; Kis L; Lindh C; Mitura P; Stepulak A; Corvigno S; Hartman J; Micke P; Mezheyeuski A; Strell C; Carlson JW; Moro CF; Dahlstrand H; Ostman A; Matsumoto K; Wiklund P; Oya M; Miyakawa A; Deisseroth K; Uhlen P
Conference publication: CANCER RESEARCH. 2018;78(4)
Digital image analysis of Ki67 in hot spots is superior to alternative proliferation associated markers in breast cancer
Robertson S; Stalhammar G; Wedlund L; Gholizadeh S; Lippert M; Rantaleinen M; Bergh J; Hartman J
Conference publication: CANCER RESEARCH. 2017;77:p2-03-03-p2-03-03
Molecular differences between screen-detected and interval breast cancers are largely explained by PAM50 subtypes
Czene K; Ivansson E; Klevebring D; Tobin NP; Lindstrom LS; Holm J; Prochazka G; Hilliges C; Palmgren J; Tornberg S; Humphreys K; Hartman J; Frisell J; Rantalainen M; Lindberg J; Hall P; Bergh J; Gronberg H; Li J
Meeting abstract: CANCER RESEARCH. 2017;77:p6-01-04-p6-01-04
Evolutionary analyses of matched primary and metastatic breast cancer reveal both linear and parallel progression with lack of axillary lymph node involvement
Ullah I; Muralidharan KG; Alkodsi A; Kjallquist U; Stalhammar G; Lovrot J; Martinez NF; Lagergren J; Hautaniemi S; Hartman J; Bergh J
Conference publication: ANNALS OF ONCOLOGY. 2017;28
Prognosis after loco-regional recurrence of breast cancer: 35 years longitudinal data from the Stockholm cancer register
Falato C; Eriksson L; Sofiadis A; Taylor SK; Nordblom A; Fredriksson I; Hartman J; Bergh J; Foukakis T
Conference publication: CANCER RESEARCH. 2016;76:3933
CETSA as a diagnostic tool to guide personalized breast cancer therapy
Oeberg A; Laursen H; Packham S; Molina DM; Seki T; Cao Y; Hartman J; Bergh J; Nordlund P; Loeoef S
Conference publication: CANCER RESEARCH. 2016;76:p6-07-09-p6-07-09
Somatic mutations in A kinase anchoring proteins (AKAPs) in metastatic tumors - A potential characteristic of breast cancer metastasis
Kjallquist U; Erlandsson R; Alkodsi A; Tobin N; Karlsson E; Hatschek T; Hartman J; Linnarsson S; Bergh J
Conference publication: EUROPEAN JOURNAL OF CANCER. 2016;57:S130
Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A kinase anchoring protein family (AKAPs)
Kjallquist U; Erlandsson R; Hartman J; Alkodsi A; Tobin N; Hatschek T; Bergh J; Linnarsson S
Conference publication: CANCER RESEARCH. 2016;76
Digital image analysis outperforms manual scoring for breast cancer subclassification and prognostication
Stalhammar G; Rosin G; Kis L; Lippert M; Moelholm I; Grunkin M; Bergh J; Hartman J
Letter: HISTOPATHOLOGY. 2015;66(5):756-758
Response to correspondence on 'Low concordance of biomarkers in histopathological and cytological material from breast cancer'
Stalhammar G; Hartman J
Conference publication: MODERN PATHOLOGY. 2014;27:78A-79A
Exome Sequencing of Mammospheres and Primary Tumors Indicates Dynamic Transitions between Stem-Like and Differentiated States in Breast Cancer
Rosin G; Klevebring D; Ma R; Fredriksson I; Bergh J; Hartman J
Conference publication: LABORATORY INVESTIGATION. 2014;94:78A-79A
Exome Sequencing of Mammospheres and Primary Tumors Indicates Dynamic Transitions between Stem-Like and Differentiated States in Breast Cancer
Rosin G; Klevebring D; Ma R; Fredriksson I; Bergh J; Hartman J
Conference publication: CANCER RESEARCH. 2013;73:ot1-2-03-ot1-2-03
A prospective randomized phase II study to identify predictive biomarkers and mechanisms of resistance in patients with HER2-negative metastatic breast cancer treated with the combination of bevacizumab and paclitaxel
Foukakis T; Hartman J; Stone-Elander S; Jacobsson H; Bergh J
Conference publication: CANCER RESEARCH. 2013;73:p4-07-12-p4-07-12
miR-206 inhibits cell migration through direct targeting of the actin-binding protein coronin 1C in triple-negative breast cancer
Wang J; Tsouko E; Jonsson P; Bergh J; Hartman J; Aydogdu E; Williams C
Conference publication: CANCER RESEARCH. 2013;73(8):4915
Estrogen receptor β is expressed within breast cancer cells with stem cell like capacity and confers endocrine sensitivity
Ma R; Govindasamy KM; Rosin G; Gustafsson J; Katchy A; Lindstrom L; Hilliges C; Viberg L; Blomqvist L; Frisell J; Williams C; Fredriksson I; Bergh J; Hartman J
Review: STEROIDS. 2012;77(12):1262-1266
Current concepts and significance of estrogen receptor β in prostate cancer
Hartman J; Stroem A; Gustafsson J-A
Editorial comment: CANCER PREVENTION RESEARCH. 2010;3(8):897-899
Estrogen Receptors in Colorectal Cancer: Goalkeepers, Strikers, or Bystanders?
Hartman J; Gustafsson J-A
Conference publication: ENDOCRINE JOURNAL. 2010;57:S321
Targeting of estrogen receptor beta as a future cancer treatment
Gustafsson J-A; Warner M; Strom A; Hartman J
Review: STEROIDS. 2009;74(8):635-641
Estrogen receptor beta in breast cancer-Diagnostic and therapeutic implications
Hartman J; Strom A; Gustafsson J-A
Conference publication: CANCER RESEARCH. 2009;69(24):642S
Function of HES6 an Inhibitor of HES1, in the Breast Cancer Cell Lines T47D and MCF-7 Is to Up-Regulate E2F-1 and Increased Proliferation
Strom AM; Hartman J; Lam EW-F; Lin C-Y; Gustafsson J-A
Thesis / dissertation: 2008
Antiproliferative action of estrogen receptor beta and Hes-1 in breast cancer
Hartman, Johan
Review: PHYSIOLOGICAL REVIEWS. 2007;87(3):905-931
Estrogen receptors:: How do they signal and what are their targets
Heldring N; Pike A; Andersson S; Matthews J; Cheng G; Hartman J; Tujague M; Stroem A; Treuter E; Warner M; Gustafsson J-A
Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(21):8298
Estrogen receptor β inhibits 17β-estradiol-stimulated proliferation of the breast cancer cell line T47D (vol 101, pg 1566, 2004)
Ström A; Hartman J; Foster JS; Kietz S; Wimalasena J; Gustafsson JA
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2006;24(18):565S
Estrogen receptor β represses breast tumor growth and angiogenesis in vivo.
Hartman J; Lindberg K; Inzunza J; Wan J; Ström A; Gustafsson J
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Professor/Överläkare, Onkologi-Patologi, Karolinska Institutet, 2023-

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Docent, Experimentell patologi, Karolinska Institutet, 2015
Läkarexamen, Karolinska Institutet, 2008
Medicine Doktorsexamen, Institutionen för biovetenskaper och näringslära, Karolinska Institutet, 2008

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Priset för innovation och nyttogörande, Karolinska Institutet, 2023
Athenapriset, Vetenskapsrådet/LIF/Dagens Medicin, https://www.dagensmedicin.se/alla-nyheter/utmarkelser/arets-vinnare-av-athenapriset-sorterar-brostcancer-med-ai/, 2022
Sophiastipendiet, Sophiahemmet Hospital, 2020
Clinical Investigator award, Swedish Cancer Society, 2016
Alvarengas pris, Swedish Society of Medicine, 2013
Asklepios pris, Swedish Society of Medicine, 2009
The McKinsey Award, 2007
Anders Wall pris, 2006

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