Joel Nordin

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Journal article: ADVANCED SCIENCE. 2024;11(42):e2407619
Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles
Zickler AM; Liang X; Gupta D; Mamand DR; De Luca M; Corso G; Errichelli L; Hean J; Sen T; Elsharkasy OM; Kamei N; Niu Z; Zhou G; Zhou H; Roudi S; Wiklander OPB; Gorgens A; Nordin JZ; Castilla-Llorente V; EL Andaloussi S
Article: NATURE BIOMEDICAL ENGINEERING. 2024;8(11):1453-1468
Antibody-displaying extracellular vesicles for targeted cancer therapy
Wiklander OPB; Mamand DR; Mohammad DK; Zheng W; Jawad Wiklander R; Sych T; Zickler AM; Liang X; Sharma H; Lavado A; Bost J; Roudi S; Corso G; Lennaard AJ; Abedi-Valugerdi M; Maeger I; Alici E; Sezgin E; Nordin JZ; Gupta D; Goergens A; EL Andaloussi S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2024;13(7):e12471
Extracellular vesicles originating from melanoma cells promote dysregulation in haematopoiesis as a component of cancer immunoediting
Mamand DR; Bazaz S; Mohammad DK; Liang X; Pavlova S; Mim C; Gabrielsson S; Nordin JZ; Wiklander OPB; Abedi-Valugerdi M; EL-Andaloussi S
Article: NATURE COMMUNICATIONS. 2023;14(1):4734
Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles
Zheng W; Raedler J; Sork H; Niu Z; Roudi S; Bost JPP; Goergens A; Zhao Y; Mamand DRR; Liang X; Wiklander OPB; Lehto T; Gupta D; Nordin JZZ; EL Andaloussi S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(7):e12248
Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models
Liang X; Niu Z; Galli V; Howe N; Zhao Y; Wiklander OPB; Zheng W; Wiklander RJ; Corso G; Davies C; Hean J; Kyriakopoulou E; Mamand DR; Amin R; Nordin JZ; Gupta D; Andaloussi SEL
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2021;10(12):e12142
Extracellular vesicles are the primary source of blood-borne tumour-derived mutant KRAS DNA early in pancreatic cancer
Hagey DW; Kordes M; Gorgens A; Mowoe MO; Nordin JZ; Moro CF; Lohr J-M; El Andaloussi S
Article: NATURE BIOMEDICAL ENGINEERING. 2021;5(9):1084-1098
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles.
Gupta D; Wiklander OPB; Görgens A; Conceição M; Corso G; Liang X; Seow Y; Balusu S; Feldin U; Bostancioglu B; Jawad R; Mamand DR; Lee YXF; Hean J; Mäger I; Roberts TC; Gustafsson M; Mohammad DK; Sork H; Backlund A; Lundin P; de Fougerolles A; Smith CIE; Wood MJA; Vandenbroucke RE; Nordin JZ; El-Andaloussi S
Article: CELLS. 2021;10(6):1543
Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion
Sork H; Conceicao M; Corso G; Nordin J; Lee YXF; Krjutskov K; Orzechowski Westholm J; Vader P; Pauwels M; Vandenbroucke RE; Wood MJA; EL Andaloussi S; Mager I
Article: PHARMACEUTICS. 2021;13(6):878
Efficient Peptide-Mediated In Vitro Delivery of Cas9 RNP
Gustafsson O; Radler J; Roudi S; Lehto T; Hallbrink M; Lehto T; Gupta D; EL Andaloussi S; Nordin JZ
Article: FRONTIERS IN PHYSIOLOGY. 2021;12:689179
Fine Tuning of Phosphorothioate Inclusion in 2′-O-Methyl Oligonucleotides Contributes to Specific Cell Targeting for Splice-Switching Modulation
Aoki Y; Rocha CSJ; Lehto T; Miyatake S; Johansson H; Hashimoto Y; Nordin JZ; Mager I; Aoki M; Graham M; Sathyaprakash C; Roberts TC; Wood MJA; Behlke MA; El Andaloussi S
Article: FRONTIERS IN PHYSIOLOGY. 2021;12:698166
Lipidomic Analyses Reveal Specific Alterations of Phosphatidylcholine in Dystrophic Mdx Muscle
Valentine WJ; Mostafa SA; Tokuoka SM; Hamano F; Inagaki NF; Nordin JZ; Motohashi N; Kita Y; Aoki Y; Shimizu T; Shindou H
Article: BIOMATERIALS. 2021;266:120435
Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle
Conceica M; Forcina L; Wiklander OPB; Gupta D; Nordin JZ; Vrellaku B; McClorey G; Mager I; Gorgens A; Lundin P; Musaro A; Wood MJA; Andaloussi SEL; Roberts TC
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1800222
Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging
Gupta D; Liang X; Pavlova S; Wiklander OPB; Corso G; Zhao Y; Saher O; Bost J; Zickler AM; Piffko A; Maire CL; Ricklefs FL; Gustafsson O; Llorente VC; Gustafsson MO; Bostancioglu RB; Mamand DR; Hagey DW; Goergens A; Nordin JZ; EL Andaloussi S
Article: ADVANCED FUNCTIONAL MATERIALS. 2019;29(48)
Supramolecular Assembly of Aminoethylene-Lipopeptide PMO Conjugates into RNA Splice-Switching Nanomicelles
Kuhn J; Klein PM; Al Danaf N; Nordin JZ; Reinhard S; Loy DM; Hoehn M; El Andaloussi S; Lamb DC; Wagner E; Aoki Y; Lehto T; Laechelt U
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2019;8(1):1663043
Systematic characterization of extracellular vesicles sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging
Corso G; Heusermann W; Trojer D; Goergens A; Steib E; Voshol J; Graff A; Genoud C; Lee Y; Hean J; Nordin JZ; Wiklander OPB; El Andaloussi S; Meisner-Kober N
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1953:287-299
Tangential Flow Filtration with or Without Subsequent Bind-Elute Size Exclusion Chromatography for Purification of Extracellular Vesicles.
Nordin JZ; Bostancioglu RB; Corso G; El Andaloussi S
Article: SCIENTIFIC REPORTS. 2018;8(1):10813
Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome
Sork H; Corso G; Krjutskov K; Johansson HJ; Nordin JZ; Wiklander OPB; Lee YXF; Westholm JO; Lehtio J; Wood MJA; Mager I; El Andaloussi S
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1326
Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures
Wiklander OPB; Bostancioglu RB; Welsh JA; Zickler AM; Murke F; Corso G; Felldin U; Hagey DW; Evertsson B; Liang X-M; Gustafsson MO; Mohammad DK; Wiek C; Hanenberg H; Bremer M; Gupta D; Bjornstedt M; Giebel B; Nordin JZ; Jones JC; EL Andaloussi S; Goergens A
Article: SCIENTIFIC REPORTS. 2017;7(1):11561
Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography
Corso G; Mager I; Lee Y; Gorgens A; Bultema J; Giebel B; Wood MJA; Nordin JZ; Andaloussi SEL
Article: METHODS IN MOLECULAR BIOLOGY. 2017;1545:197-204
Preparation and Isolation of siRNA-Loaded Extracellular Vesicles.
Vader P; Mäger I; Lee Y; Nordin JZ; Andaloussi SEL; Wood MJA
Article: DIABETOLOGIA. 2016;59(5):1049-1058
Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice
Jalabert A; Vial G; Guay C; Wiklander OPB; Nordin JZ; Aswad H; Forterre A; Meugnier E; Pesenti S; Regazzi R; Danty-Berger E; Ducreux S; Vidal H; El-Andaloussi S; Rieusset J; Rome S
Article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2016;5(3):e290
Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency
Sork H; Nordin JZ; Turunen JJ; Wiklander OPB; Bestas B; Zaghloul EM; Margus H; Padari K; Duru AD; Corso G; Bost J; Vader P; Pooga M; Smith CIE; Wood MJA; Schiffelers RM; Hallbrink M; Andaloussi SEL
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(10):1199-1213
In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome
Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalen M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Haegglund H; Mattsson M; Lentio J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Article: NANO LETTERS. 2015;15(7):4364-4373
Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides
Ezzat K; Aoki Y; Koo T; McClorey G; Benner L; Coenen-Stass A; O'Donovan L; Lehto T; Garcia-Guerra A; Nordin J; Saleh AF; Behlke M; Morris J; Goyenvalle A; Dugovic B; Leumann C; Gordon S; Gait MJ; El-Andaloussi S; Wood MJA
Article: NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE. 2015;11(4):879-883
Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties
Nordin JZ; Lee Y; Vader P; Maeger I; Johansson HJ; Heusermann W; Wiklander OPB; Hallbrink M; Seow Y; Bultema JJ; Gilthorpe J; Davies T; Fairchild PJ; Gabrielsson S; Meisner-Kober NC; Lehtio J; Smith CIE; Wood MJA; Andaloussi SEL
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26883
Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles.
Li J; Lee Y; Johansson HJ; Mäger I; Vader P; Nordin JZ; Wiklander OPB; Lehtiö J; Wood MJA; Andaloussi SE
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26316
Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting.
Wiklander OPB; Nordin JZ; O'Loughlin A; Gustafsson Y; Corso G; Mäger I; Vader P; Lee Y; Sork H; Seow Y; Heldring N; Alvarez-Erviti L; Smith CIE; Le Blanc K; Macchiarini P; Jungebluth P; Wood MJA; Andaloussi SE
Article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2014;3(11):e212
Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides
Hammond SM; McClorey G; Nordin JZ; Godfrey C; Stenler S; Lennox KA; Smith CIE; Jacobi AM; Varela MA; Lee Y; Behlke MA; Wood MJA; Andaloussi SEL
Article: MOVEMENT DISORDERS. 2014;29(12):1476-1485
Systemic Exosomal siRNA Delivery Reduced Alpha-Synuclein Aggregates in Brains of Transgenic Mice
Cooper JM; Wiklander PBO; Nordin JZ; Al-Shawi R; Wood MJ; Vithlani M; Schapira AHV; Simons JP; El-Andaloussi S; Alvarez-Erviti L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(9):4067-4081
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model
Bestas B; Moreno PMD; Blomberg KEM; Mohammad DK; Saleh AF; Sutlu T; Nordin JZ; Guterstam P; Gustafsson MO; Kharazi S; Piatosa B; Roberts TC; Behlke MA; Wood MJA; Gait MJ; Lundin KE; El Andaloussi S; Mansson R; Berglof A; Wengel J; Smith CIE
Article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2014;3(1):e140
Micro-minicircle Gene Therapy: Implications of Size on Fermentation, Complexation, Shearing Resistance, and Expression
Stenler S; Wiklander OPB; Badal-Tejedor M; Turunen J; Nordin JZ; Hallengard D; Wahren B; Andaloussi SEL; Rutland MW; Smith CIE; Lundin KE; Blomberg P
Article: BRITISH JOURNAL OF SURGERY. 2014;101(2):100-108
Diagnostic value of abdominal drainage in individual risk assessment of pancreatic fistula following pancreaticoduodenectomy
Ansorge C; Nordin JZ; Lundell L; Strommer L; Rangelova E; Blomberg J; del Chiaro M; Segersvard R
Journal article: PANCREATOLOGY. 2013;13(3):s82
The diagnostic value of pancreatic amylase analyses from prophylactic abdominal drainage in identifying pancreatic fistula following pancreaticoduodenectomy
Ansorge C; Nordin J; Strömmer L; Lundell L; Rangelova E; Blomberg J; del Chiaro M; Segersvärd R
Visa fler

Alla övriga publikationer

Preprint: BIORXIV. 2024
Advanced Peptide Nanoparticles Enable Robust and Efficient delivery of gene editors across cell types
Gustafsson O; Krishna S; Borate S; Ghaeidamini M; Liang X; Saher O; Cuellar R; Birdsong BK; Roudi S; Estupiñán HY; Alici E; Smith CE; Esbjörner EK; Spuler S; de Jong OG; Escobar H; Nordin JZ; Andaloussi SE
Preprint: BIORXIV. 2024
Histones are exosome membrane proteins regulated by cell stress
Singh B; Sundbom MF; Muthukrishnan U; Natarajan B; Stransky S; Görgens A; Nordin J; Wiklander O; Sandblad L; Sidoli S; Andaloussi SEL; Haney M; Gilthorpe J
Preprint: RESEARCH SQUARE. 2023
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
Liang X; Gupta D; Xie J; Wonterghem E; Hoecke L; Hean J; Niu Z; Wiklander O; Zheng W; Wiklander R; He R; Mammad D; Bost J; Zhou G; Zhou H; Roudi S; Zickler A; Gorgens A; Hagey D; de Jong O; Uy A; Zong Y; Mager I; Perez C; Roberts T; Vader P; Fougerolles A; Wood M; Vandenbroucke R; Nordin J; El-Andaloussi S
Preprint: BIORXIV. 2023
Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles
Zheng W; Rädler J; Sork H; Niu Z; Roudi S; Bost J; Görgens A; Zhao Y; Mamand D; Liang X; Wiklander O; Lehto T; Gupta D; Nordin J; EL Andaloussi S
Preprint: BIORXIV. 2023
Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery
Liang X; Gupta D; Xie J; Wonterghem EV; Hoecke LV; Hean J; Niu Z; Wiklander O; Zheng W; Wiklander RJ; He R; Mamand D; Bost J; Zhou G; Zhou H; Roudi S; Zickler AM; Gorgens A; Hagey D; de Jong O; Uy AG; Zong Y; Mager I; Perez CM; Roberts T; Vader P; Fougerolles AD; Wood M; Vandenbroucke R; Nordin J; EL Andaloussi S
Preprint: BIORXIV. 2023
Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles
Zickler A; Liang X; Gupta D; Mamand D; Luca MD; Corso G; Errichelli L; Hean J; Sen T; Elsharkasy O; Kamei N; Niu Z; Zhou G; Zhou H; Roudi S; Wiklander O; Görgens A; Nordin J; Castilla-Llorente V; Andaloussi SEL
Editorial comment: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(10):e12227
Transfection reagents affect Extracellular Vesicle cargo transfer to recipient cells: The importance of appropriate controls in EV research
Nordin JZ
Conference publication: MOLECULAR THERAPY. 2022;30(4):285-286
Peptide-Mediated Delivery of Gene Editing Modalities
Gustafsson O; Roudi S; Gupta D; Liang X; de Jong O; Vader P; Nordin J; Andaloussi SEL
Conference publication: MOLECULAR THERAPY. 2021;29(4):332-333
Antibody Displaying Extracellular Vesicles (Fc-EVs) for Delivery of Tumor Targeted Therapeutics
Wiklander OPB; Jawad R; Mamand DR; Sharma H; Liang X; Gupta D; Bost J; Zickler AM; Zheng W; Nordin JZ; Gorgens A; Andaloussi SEL
Conference publication: MOLECULAR THERAPY. 2021;29(4):220
Albumin-Decorated Exosomes Demonstrate Extended Circulation Time In Vivo
Liang X; Gupta D; Galli V; Zheng W; Davies C; Hean J; Kyriakopoulou E; Yang X; de Andres J; Mamand DR; Amin R; Niu Z; Jawad R; Wiklander O; Zickler A; Gustafsson M; Gorgens A; Nordin JZ; EL Andaloussi S
Preprint: BIORXIV. 2020
Engineering of extracellular vesicles for display of protein biotherapeutics
Gupta D; Wiklander OPB; Görgens A; Conceição M; Corso G; Liang X; Seow Y; Balsu S; Felldin U; Bostancioglu B; Fiona Lee YX; Hean J; Mäger I; Roberts T; Gustafsson M; Mohammad D; Sork H; Bäcklund A; Edvard Smith CI; Wood MJA; Vandenbroucke R; Nordin J; Andaloussi SEL
Preprint: BIORXIV. 2020
Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle
Conceição M; Forcina L; Wiklander O; Gupta D; Nordin J; McClorey G; Mäger I; Görgens A; Lundin P; Musarò A; Wood M; Andaloussi SEL; Roberts T
Review: ADVANCED DRUG DELIVERY REVIEWS. 2020;159:332-343
Extracellular vesicles as drug delivery systems: Why and how?
Elsharkasy OM; Nordin JZ; Hagey DW; de Jong OG; Schiffelers RM; EL Andaloussi S; Vader P
Editorial comment: JOURNAL OF PATHOLOGY. 2019;249(3):271-273
Autoimmune response and its long-term consequences after exon-skipping therapy in a Duchenne muscular dystrophy mouse model
Nordin JZ; Aoki Y
Thesis / dissertation: 2017
Purification and biodistribution of extracellular vesicles
Nordin, Joel Z
Corrigendum: STEM CELLS TRANSLATIONAL MEDICINE. 2016;5(6):845
In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome (vol 4, pg 1199, 2015)
Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalen M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Hagglund H; Mattsson M; Lehtio J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Conference publication: JOURNAL OF CLINICAL IMMUNOLOGY. 2014;34:S152
Personalized Therapy for X-Linked Agammaglobulinemia (XLA) by Oligonucleotide-Induced Splice-Correction
Smith CIE; Bestas B; Moreno PMD; Berglof B; Blomberg KEM; Mohammad DK; Saleh AF; Sutlu T; Lundin KE; Nordin JZ; Kharazi S; Manson R; EL Andaloussi S; Gait MJ; Wengel J
Conference publication: HUMAN GENE THERAPY. 2014;25(11):A114
Personalized therapy for X-linked agammaglobulinemia (XLA) by oligonucleotide-induced splice-correction
Bestas B; Moreno PMD; Blomberg KEM; Mohammad DK; Saleh AF; Sutlu T; Nordin JZ; Guterstam P; Kharazi S; Behlke MA; Wood MJA; Gait MJ; Lundin KE; Andaloussi SEL; Mansson R; Berglof A; Wengel J; Smith CIE

Forskningsbidrag

Extracellular Vesicles as mediators for intracellular delivery of macromolecules using engineered cells
Swedish Research Council
1 December 2021 - 30 November 2024

Anställningar

Biträdande Lektor, Laboratoriemedicin, Karolinska Institutet, 2022-2027

Examina och utbildning

Medicine Doktorsexamen, Institutionen för laboratoriemedicin, Karolinska Institutet, 2017
Läkarexamen, Karolinska Institutet, 2012

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI