Joel Nordin

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Journal article: ADVANCED SCIENCE. 2024;11(42):e2407619
Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles
Zickler AM; Liang X; Gupta D; Mamand DR; De Luca M; Corso G; Errichelli L; Hean J; Sen T; Elsharkasy OM; Kamei N; Niu Z; Zhou G; Zhou H; Roudi S; Wiklander OPB; Gorgens A; Nordin JZ; Castilla-Llorente V; EL Andaloussi S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2024;13(7):e12471
Extracellular vesicles originating from melanoma cells promote dysregulation in haematopoiesis as a component of cancer immunoediting
Mamand DR; Bazaz S; Mohammad DK; Liang X; Pavlova S; Mim C; Gabrielsson S; Nordin JZ; Wiklander OPB; Abedi-Valugerdi M; EL-Andaloussi S
Article: NATURE BIOMEDICAL ENGINEERING. 2024;:1-16
Antibody-displaying extracellular vesicles for targeted cancer therapy
Wiklander OPB; Mamand DR; Mohammad DK; Zheng W; Jawad Wiklander R; Sych T; Zickler AM; Liang X; Sharma H; Lavado A; Bost J; Roudi S; Corso G; Lennaard AJ; Abedi-Valugerdi M; Mager I; Alici E; Sezgin E; Nordin JZ; Gupta D; Gorgens A; EL Andaloussi S
Article: NATURE COMMUNICATIONS. 2023;14(1):4734
Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles
Zheng W; Raedler J; Sork H; Niu Z; Roudi S; Bost JPP; Goergens A; Zhao Y; Mamand DRR; Liang X; Wiklander OPB; Lehto T; Gupta D; Nordin JZZ; EL Andaloussi S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(7):e12248
Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models
Liang X; Niu Z; Galli V; Howe N; Zhao Y; Wiklander OPB; Zheng W; Wiklander RJ; Corso G; Davies C; Hean J; Kyriakopoulou E; Mamand DR; Amin R; Nordin JZ; Gupta D; Andaloussi SEL
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2021;10(12):e12142
Extracellular vesicles are the primary source of blood-borne tumour-derived mutant KRAS DNA early in pancreatic cancer
Hagey DW; Kordes M; Gorgens A; Mowoe MO; Nordin JZ; Moro CF; Lohr J-M; El Andaloussi S
Article: NATURE BIOMEDICAL ENGINEERING. 2021;5(9):1084-1098
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles.
Gupta D; Wiklander OPB; Görgens A; Conceição M; Corso G; Liang X; Seow Y; Balusu S; Feldin U; Bostancioglu B; Jawad R; Mamand DR; Lee YXF; Hean J; Mäger I; Roberts TC; Gustafsson M; Mohammad DK; Sork H; Backlund A; Lundin P; de Fougerolles A; Smith CIE; Wood MJA; Vandenbroucke RE; Nordin JZ; El-Andaloussi S
Article: CELLS. 2021;10(6):1543
Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion
Sork H; Conceicao M; Corso G; Nordin J; Lee YXF; Krjutskov K; Orzechowski Westholm J; Vader P; Pauwels M; Vandenbroucke RE; Wood MJA; EL Andaloussi S; Mager I
Article: PHARMACEUTICS. 2021;13(6):878
Efficient Peptide-Mediated In Vitro Delivery of Cas9 RNP
Gustafsson O; Radler J; Roudi S; Lehto T; Hallbrink M; Lehto T; Gupta D; EL Andaloussi S; Nordin JZ
Article: FRONTIERS IN PHYSIOLOGY. 2021;12:689179
Fine Tuning of Phosphorothioate Inclusion in 2′-O-Methyl Oligonucleotides Contributes to Specific Cell Targeting for Splice-Switching Modulation
Aoki Y; Rocha CSJ; Lehto T; Miyatake S; Johansson H; Hashimoto Y; Nordin JZ; Mager I; Aoki M; Graham M; Sathyaprakash C; Roberts TC; Wood MJA; Behlke MA; El Andaloussi S
Article: FRONTIERS IN PHYSIOLOGY. 2021;12:698166
Lipidomic Analyses Reveal Specific Alterations of Phosphatidylcholine in Dystrophic Mdx Muscle
Valentine WJ; Mostafa SA; Tokuoka SM; Hamano F; Inagaki NF; Nordin JZ; Motohashi N; Kita Y; Aoki Y; Shimizu T; Shindou H
Article: BIOMATERIALS. 2021;266:120435
Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle
Conceica M; Forcina L; Wiklander OPB; Gupta D; Nordin JZ; Vrellaku B; McClorey G; Mager I; Gorgens A; Lundin P; Musaro A; Wood MJA; Andaloussi SEL; Roberts TC
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1800222
Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging
Gupta D; Liang X; Pavlova S; Wiklander OPB; Corso G; Zhao Y; Saher O; Bost J; Zickler AM; Piffko A; Maire CL; Ricklefs FL; Gustafsson O; Llorente VC; Gustafsson MO; Bostancioglu RB; Mamand DR; Hagey DW; Goergens A; Nordin JZ; EL Andaloussi S
Article: ADVANCED FUNCTIONAL MATERIALS. 2019;29(48)
Supramolecular Assembly of Aminoethylene-Lipopeptide PMO Conjugates into RNA Splice-Switching Nanomicelles
Kuhn J; Klein PM; Al Danaf N; Nordin JZ; Reinhard S; Loy DM; Hoehn M; El Andaloussi S; Lamb DC; Wagner E; Aoki Y; Lehto T; Laechelt U
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2019;8(1):1663043
Systematic characterization of extracellular vesicles sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging
Corso G; Heusermann W; Trojer D; Goergens A; Steib E; Voshol J; Graff A; Genoud C; Lee Y; Hean J; Nordin JZ; Wiklander OPB; El Andaloussi S; Meisner-Kober N
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1953:287-299
Tangential Flow Filtration with or Without Subsequent Bind-Elute Size Exclusion Chromatography for Purification of Extracellular Vesicles.
Nordin JZ; Bostancioglu RB; Corso G; El Andaloussi S
Article: SCIENTIFIC REPORTS. 2018;8(1):10813
Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome
Sork H; Corso G; Krjutskov K; Johansson HJ; Nordin JZ; Wiklander OPB; Lee YXF; Westholm JO; Lehtio J; Wood MJA; Mager I; El Andaloussi S
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1326
Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures
Wiklander OPB; Bostancioglu RB; Welsh JA; Zickler AM; Murke F; Corso G; Felldin U; Hagey DW; Evertsson B; Liang X-M; Gustafsson MO; Mohammad DK; Wiek C; Hanenberg H; Bremer M; Gupta D; Bjornstedt M; Giebel B; Nordin JZ; Jones JC; EL Andaloussi S; Goergens A
Article: SCIENTIFIC REPORTS. 2017;7(1):11561
Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography
Corso G; Mager I; Lee Y; Gorgens A; Bultema J; Giebel B; Wood MJA; Nordin JZ; Andaloussi SEL
Article: METHODS IN MOLECULAR BIOLOGY. 2017;1545:197-204
Preparation and Isolation of siRNA-Loaded Extracellular Vesicles.
Vader P; Mäger I; Lee Y; Nordin JZ; Andaloussi SEL; Wood MJA
Article: DIABETOLOGIA. 2016;59(5):1049-1058
Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice
Jalabert A; Vial G; Guay C; Wiklander OPB; Nordin JZ; Aswad H; Forterre A; Meugnier E; Pesenti S; Regazzi R; Danty-Berger E; Ducreux S; Vidal H; El-Andaloussi S; Rieusset J; Rome S
Article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2016;5(3):e290
Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency
Sork H; Nordin JZ; Turunen JJ; Wiklander OPB; Bestas B; Zaghloul EM; Margus H; Padari K; Duru AD; Corso G; Bost J; Vader P; Pooga M; Smith CIE; Wood MJA; Schiffelers RM; Hallbrink M; Andaloussi SEL
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(10):1199-1213
In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome
Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalen M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Haegglund H; Mattsson M; Lentio J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Article: NANO LETTERS. 2015;15(7):4364-4373
Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides
Ezzat K; Aoki Y; Koo T; McClorey G; Benner L; Coenen-Stass A; O'Donovan L; Lehto T; Garcia-Guerra A; Nordin J; Saleh AF; Behlke M; Morris J; Goyenvalle A; Dugovic B; Leumann C; Gordon S; Gait MJ; El-Andaloussi S; Wood MJA
Article: NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE. 2015;11(4):879-883
Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties
Nordin JZ; Lee Y; Vader P; Maeger I; Johansson HJ; Heusermann W; Wiklander OPB; Hallbrink M; Seow Y; Bultema JJ; Gilthorpe J; Davies T; Fairchild PJ; Gabrielsson S; Meisner-Kober NC; Lehtio J; Smith CIE; Wood MJA; Andaloussi SEL
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26883
Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles.
Li J; Lee Y; Johansson HJ; Mäger I; Vader P; Nordin JZ; Wiklander OPB; Lehtiö J; Wood MJA; Andaloussi SE
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26316
Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting.
Wiklander OPB; Nordin JZ; O'Loughlin A; Gustafsson Y; Corso G; Mäger I; Vader P; Lee Y; Sork H; Seow Y; Heldring N; Alvarez-Erviti L; Smith CIE; Le Blanc K; Macchiarini P; Jungebluth P; Wood MJA; Andaloussi SE
Article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2014;3(11):e212
Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides
Hammond SM; McClorey G; Nordin JZ; Godfrey C; Stenler S; Lennox KA; Smith CIE; Jacobi AM; Varela MA; Lee Y; Behlke MA; Wood MJA; Andaloussi SEL
Article: MOVEMENT DISORDERS. 2014;29(12):1476-1485
Systemic Exosomal siRNA Delivery Reduced Alpha-Synuclein Aggregates in Brains of Transgenic Mice
Cooper JM; Wiklander PBO; Nordin JZ; Al-Shawi R; Wood MJ; Vithlani M; Schapira AHV; Simons JP; El-Andaloussi S; Alvarez-Erviti L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(9):4067-4081
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model
Bestas B; Moreno PMD; Blomberg KEM; Mohammad DK; Saleh AF; Sutlu T; Nordin JZ; Guterstam P; Gustafsson MO; Kharazi S; Piatosa B; Roberts TC; Behlke MA; Wood MJA; Gait MJ; Lundin KE; El Andaloussi S; Mansson R; Berglof A; Wengel J; Smith CIE
Article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2014;3(1):e140
Micro-minicircle Gene Therapy: Implications of Size on Fermentation, Complexation, Shearing Resistance, and Expression
Stenler S; Wiklander OPB; Badal-Tejedor M; Turunen J; Nordin JZ; Hallengard D; Wahren B; Andaloussi SEL; Rutland MW; Smith CIE; Lundin KE; Blomberg P
Article: BRITISH JOURNAL OF SURGERY. 2014;101(2):100-108
Diagnostic value of abdominal drainage in individual risk assessment of pancreatic fistula following pancreaticoduodenectomy
Ansorge C; Nordin JZ; Lundell L; Strommer L; Rangelova E; Blomberg J; del Chiaro M; Segersvard R
Journal article: PANCREATOLOGY. 2013;13(3):s82
The diagnostic value of pancreatic amylase analyses from prophylactic abdominal drainage in identifying pancreatic fistula following pancreaticoduodenectomy
Ansorge C; Nordin J; Strömmer L; Lundell L; Rangelova E; Blomberg J; del Chiaro M; Segersvärd R
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Preprint: BIORXIV. 2024
Histones are exosome membrane proteins regulated by cell stress
Singh B; Sundbom MF; Muthukrishnan U; Natarajan B; Stransky S; Görgens A; Nordin J; Wiklander O; Sandblad L; Sidoli S; Andaloussi SEL; Haney M; Gilthorpe J
Preprint: RESEARCH SQUARE. 2023
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
Liang X; Gupta D; Xie J; Wonterghem E; Hoecke L; Hean J; Niu Z; Wiklander O; Zheng W; Wiklander R; He R; Mammad D; Bost J; Zhou G; Zhou H; Roudi S; Zickler A; Gorgens A; Hagey D; de Jong O; Uy A; Zong Y; Mager I; Perez C; Roberts T; Vader P; Fougerolles A; Wood M; Vandenbroucke R; Nordin J; El-Andaloussi S
Preprint: BIORXIV. 2023
Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles
Zheng W; Rädler J; Sork H; Niu Z; Roudi S; Bost J; Görgens A; Zhao Y; Mamand D; Liang X; Wiklander O; Lehto T; Gupta D; Nordin J; EL Andaloussi S
Preprint: BIORXIV. 2023
Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery
Liang X; Gupta D; Xie J; Wonterghem EV; Hoecke LV; Hean J; Niu Z; Wiklander O; Zheng W; Wiklander RJ; He R; Mamand D; Bost J; Zhou G; Zhou H; Roudi S; Zickler AM; Gorgens A; Hagey D; de Jong O; Uy AG; Zong Y; Mager I; Perez CM; Roberts T; Vader P; Fougerolles AD; Wood M; Vandenbroucke R; Nordin J; EL Andaloussi S
Preprint: BIORXIV. 2023
Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles
Zickler A; Liang X; Gupta D; Mamand D; Luca MD; Corso G; Errichelli L; Hean J; Sen T; Elsharkasy O; Kamei N; Niu Z; Zhou G; Zhou H; Roudi S; Wiklander O; Görgens A; Nordin J; Castilla-Llorente V; Andaloussi SEL
Editorial comment: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(10):e12227
Transfection reagents affect Extracellular Vesicle cargo transfer to recipient cells: The importance of appropriate controls in EV research
Nordin JZ
Conference publication: MOLECULAR THERAPY. 2022;30(4):285-286
Peptide-Mediated Delivery of Gene Editing Modalities
Gustafsson O; Roudi S; Gupta D; Liang X; de Jong O; Vader P; Nordin J; Andaloussi SEL
Conference publication: MOLECULAR THERAPY. 2021;29(4):332-333
Antibody Displaying Extracellular Vesicles (Fc-EVs) for Delivery of Tumor Targeted Therapeutics
Wiklander OPB; Jawad R; Mamand DR; Sharma H; Liang X; Gupta D; Bost J; Zickler AM; Zheng W; Nordin JZ; Gorgens A; Andaloussi SEL
Conference publication: MOLECULAR THERAPY. 2021;29(4):220
Albumin-Decorated Exosomes Demonstrate Extended Circulation Time In Vivo
Liang X; Gupta D; Galli V; Zheng W; Davies C; Hean J; Kyriakopoulou E; Yang X; de Andres J; Mamand DR; Amin R; Niu Z; Jawad R; Wiklander O; Zickler A; Gustafsson M; Gorgens A; Nordin JZ; EL Andaloussi S
Preprint: BIORXIV. 2020
Engineering of extracellular vesicles for display of protein biotherapeutics
Gupta D; Wiklander OPB; Görgens A; Conceição M; Corso G; Liang X; Seow Y; Balsu S; Felldin U; Bostancioglu B; Fiona Lee YX; Hean J; Mäger I; Roberts T; Gustafsson M; Mohammad D; Sork H; Bäcklund A; Edvard Smith CI; Wood MJA; Vandenbroucke R; Nordin J; Andaloussi SEL
Preprint: BIORXIV. 2020
Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle
Conceição M; Forcina L; Wiklander O; Gupta D; Nordin J; McClorey G; Mäger I; Görgens A; Lundin P; Musarò A; Wood M; Andaloussi SEL; Roberts T
Review: ADVANCED DRUG DELIVERY REVIEWS. 2020;159:332-343
Extracellular vesicles as drug delivery systems: Why and how?
Elsharkasy OM; Nordin JZ; Hagey DW; de Jong OG; Schiffelers RM; EL Andaloussi S; Vader P
Editorial comment: JOURNAL OF PATHOLOGY. 2019;249(3):271-273
Autoimmune response and its long-term consequences after exon-skipping therapy in a Duchenne muscular dystrophy mouse model
Nordin JZ; Aoki Y
Thesis / dissertation: 2017
Purification and biodistribution of extracellular vesicles
Nordin, Joel Z
Corrigendum: STEM CELLS TRANSLATIONAL MEDICINE. 2016;5(6):845
In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome (vol 4, pg 1199, 2015)
Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalen M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Hagglund H; Mattsson M; Lehtio J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Conference publication: JOURNAL OF CLINICAL IMMUNOLOGY. 2014;34:S152
Personalized Therapy for X-Linked Agammaglobulinemia (XLA) by Oligonucleotide-Induced Splice-Correction
Smith CIE; Bestas B; Moreno PMD; Berglof B; Blomberg KEM; Mohammad DK; Saleh AF; Sutlu T; Lundin KE; Nordin JZ; Kharazi S; Manson R; EL Andaloussi S; Gait MJ; Wengel J
Conference publication: HUMAN GENE THERAPY. 2014;25(11):A114
Personalized therapy for X-linked agammaglobulinemia (XLA) by oligonucleotide-induced splice-correction
Bestas B; Moreno PMD; Blomberg KEM; Mohammad DK; Saleh AF; Sutlu T; Nordin JZ; Guterstam P; Kharazi S; Behlke MA; Wood MJA; Gait MJ; Lundin KE; Andaloussi SEL; Mansson R; Berglof A; Wengel J; Smith CIE

Forskningsbidrag

Extracellular Vesicles as mediators for intracellular delivery of macromolecules using engineered cells
Swedish Research Council
1 December 2021 - 30 November 2024

Anställningar

Biträdande Lektor, Laboratoriemedicin, Karolinska Institutet, 2022-2027

Examina och utbildning

Medicine Doktorsexamen, Institutionen för laboratoriemedicin, Karolinska Institutet, 2017
Läkarexamen, Karolinska Institutet, 2012

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