Joel Nordin

Joel Nordin

Assistant Professor
Telephone: +46852485850
Visiting address: Blickagången 6, 14157 Huddinge
Postal address: H5 Laboratoriemedicin, H5 BCM Joel Nordin, 141 52 Huddinge

Research

  • Research area/interest: Non-viral vectors for gene therapy, including
    membrane vesicles and in vivo applications.

Articles

All other publications

Grants

  • Swedish Research Council
    1 January 2025 - 31 December 2028
    The end goal of the project is to efficiently deliver Cas9 and a cDNA of a gene to integrate the cDNA site specifically by homology-directed repair (HDR) to treat inborn errors of immunity. I intend (aim 1) to bring state-of-the-art Cas9 HDR technology to Sweden to treat X-linked agammaglobulinemia (XLA), based on ex vivo electroporation of Cas9 and subsequent delivery of the cDNA by adeno-associated virus 6 (AAV6) developed by my collaborator at UCLA. In Aims 2&3, the HDR delivery will be further improved by developing a novel targeted nanoparticle delivering Cas9 and the cDNA template to specific cells in vivo. Thus, delivering the entire HDR machinery by a single nanoparticle to only hematopoietic stem cells (HSCs) or T-cells in vivo. I will leverage my expertise in extracellular vesicles (EVs) to create an All-in-one Delivery Vehicle (AiDV). The AiDV will be more efficient and less toxic than the electroporation/AAV6 technique and allow for the development of in vivo delivery of the HDR machinery. The project will benefit patients in a short perspective (Aim 1), by bringing HDR gene editing closer to a clinical trial, and in the long perspective by improving the treatment with the final goal of developing an in vivo treatment, which would revolutionize the treatment of primary immunodeficiencies. Hence, the project is translational and will further our arsenal to treat HSC genetic diseases and advance the ATMP and precision medicine fields at Karolinska, and Sweden.

Employments

  • Assistant Professor, Department of Laboratory Medicine, Karolinska Institutet, 2022-2027

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2017
  • University Medical Degree, Karolinska Institutet, 2012

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