Jens Hjerling-Leffler
Senior Forskare | Docent
E-postadress: jens.hjerling-leffler@ki.se
Telefon: +46852486974
Besöksadress: Solnavägen 9, 6C, 17177 Stockholm
Postadress: C2 Medicinsk biokemi och biofysik, C2 Molekylär neurobiologi Leffler, 171 77 Stockholm
Om mig
Docent och gruppledare
Arbetar med mognad av neuronala nätverk, neuronal diversitet, musgenetik,- singel-cell sekvensering, transkriptionell reglering, elektrofysiologi and
- virusbaserade verktyg.
Postdoktorvistelser
2007-2011 Fishell lab, NYU Langone Medical Center, New York, NY, US
2006-2007 Koltzenburg lab, Queen Square Centre for Neuromuscular Disease, UCL, London, UK
Doktorsutbildning
2006 Patrik Ernfors, Medicinsk Biokemi and Biofysik, Karolinska Institutet, Sverige
Forskningsvistelser under grundutbildningen
1999 Frank Pfrieger lab, Max Delbrück Center for Molecular Medicine, Berlin, Germany
Forskningsbeskrivning
- Vår forskargrupp studerar de genetiska och cellulära mekanismerna för mognaden och funktionen hos hjärnans inhibitoriska system. Vi använder oss
av avancerad musgenetik i kombination med elektrofysiologi och moderna molekylära metoder för att undersöka rollen som individuella celltyper har och hur deras funktion är baserat på vilka neuronala nätverk de ingår i.
Artiklar
- Article: NEURON. 2023;111(22):3590-3603.e5
- Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2023;75:s85-s86
- Journal article: IBRO REPORTS. 2023;15:s222
- Article: BIOLOGY DIRECT. 2023;18(1):22
- Article: STEM CELL REPORTS. 2023;18(1):337-353
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2022;109(6):1077-1091
- Journal article: BIOLOGICAL PSYCHIATRY. 2022;91(9):s293-s294
- Article: JOURNAL OF NEUROSCIENCE. 2021;41(43):8876-8886
- Article: MOLECULAR PSYCHIATRY. 2021;26(6):2070-2081
- Article: NATURE NEUROSCIENCE. 2020;23(12):1456-1468
- Article: SCIENTIFIC REPORTS. 2020;10(1):15680
- Article: ELIFE. 2020;9:e59328
- Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2020;511:110835
- Article: NATURE GENETICS. 2020;52(5):482-493
- Article: JOURNAL OF CELL BIOLOGY. 2020;219(1):e201905002
- Article: NATURE METHODS. 2020;17(1):101-106
- Article: SCIENCE. 2019;365(6454):695-699
- Article: PLOS COMPUTATIONAL BIOLOGY. 2019;15(6):e1007113
- Article: NATURE GENETICS. 2019;51(3):404-413
- Article: NATURE GENETICS. 2019;51(3):394-403
- Article: MOLECULAR PSYCHIATRY. 2019;24(2):182-197
- Article: CELL REPORTS. 2018;24(8):2179-2190.e7
- Article: DEVELOPMENTAL CELL. 2018;46(4):504-517.e7
- Article: CELL. 2018;174(4):999-1014.e22
- Article: NATURE GENETICS. 2018;50(7):912-919
- Article: NATURE GENETICS. 2018;50(7):920-927
- Article: PLOS BIOLOGY. 2018;16(6):e2006387
- Article: NATURE GENETICS. 2018;50(6):825-833
- Article: JOURNAL OF NEUROENDOCRINOLOGY. 2018;30(3):e12573
- Article: GASTROENTEROLOGY. 2018;154(3):624-636
- Article: GENOME MEDICINE. 2017;9(1):114
- Article: SCIENCE. 2017;356(6343):1168-1171
- Article: SCIENCE. 2016;352(6291):1326-1329
- Article: CEREBRAL CORTEX. 2016;26(1):96-105
- Article: JOURNAL OF CHEMICAL NEUROANATOMY. 2016;71:1-5
- Article: SCIENCE. 2015;347(6226):1138-1142
- Article: NATURE NEUROSCIENCE. 2015;18(1):145-153
- Article: NEUROBIOLOGY OF DISEASE. 2013;49:118-127
- Article: FRONTIERS IN NEURAL CIRCUITS. 2012;6:44
- Article: DEVELOPMENTAL NEUROBIOLOGY. 2011;71(1):45-61
- Article: JOURNAL OF NEUROSCIENCE. 2010;30(50):16796-16808
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(37):16336-16341
- Article: JOURNAL OF NEUROSCIENCE. 2010;30(5):1582-1594
- Article: NEURON. 2009;63(4):466-481
- Article: STEM CELLS. 2009;27(7):1592-1603
- Article: CEREBRAL CORTEX. 2009;19(Suppl 1):i1-10
- Article: BEHAVIOURAL BRAIN RESEARCH. 2009;197(2):339-346
- Article: NEURON. 2008;59(5):722-732
- Article: NATURE. 2008;451(7177):460-464
- Article: JOURNAL OF NEUROSCIENCE. 2007;27(10):2435-2443
- Journal article: EUROPEAN JOURNAL OF PAIN. 2006;10(S1):s7d-ss8
- Article: EXPERIMENTAL NEUROLOGY. 2006;198(2):438-449
- Article: CELL AND TISSUE RESEARCH. 2006;323(1):81-90
- Article: DEVELOPMENT. 2005;132(11):2623-2632
- Article: DEVELOPMENT. 2003;130(8):1479-1491
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Alla övriga publikationer
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2023;75:S85
- Preprint: BIORXIV. 2023
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:E156
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:E66-E67
- Conference publication: BIOLOGICAL PSYCHIATRY. 2022;91(9):S293-S294
- Editorial comment: CURRENT OPINION IN GENETICS AND DEVELOPMENT. 2021;68:III-IX
- Corrigendum: NATURE NEUROSCIENCE. 2021;24(4):613
- Corrigendum: NATURE NEUROSCIENCE. 2021;24(4):612
- Conference publication: DIABETOLOGIA. 2021;64(SUPPL 1):8
- Preprint: BIORXIV. 2020
- Corrigendum: NATURE GENETICS. 2020;52(3):354
- Preprint: BIORXIV. 2019
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:1104-1105
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S809-S810
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S799
- Preprint: BIORXIV. 2018
- Preprint: BIORXIV. 2018
- Preprint: BIORXIV. 2018
- Conference publication: DIABETOLOGIA. 2018;61:S117-S118
- Conference publication: JOURNAL OF SLEEP RESEARCH. 2018;27
- Conference publication: HUMAN GENOMICS. 2018;12
- Preprint: BIORXIV. 2017
- Preprint: BIORXIV. 2017
- Conference publication: MECHANISMS OF DEVELOPMENT. 2017;145:S122
- Preprint: BIORXIV. 2017
- Conference publication: DIABETOLOGIA. 2017;60:S67
- Review: NATURE NEUROSCIENCE. 2016;19(9):1131-1141
- Preprint: BIORXIV. 2015
- Conference publication: GLIA. 2015;63:E191
- Review: JOURNAL OF PHYSIOLOGY. 2012;590(4):703-714
- Conference publication: JOURNAL OF NEUROCHEMISTRY. 2009;108:1
- Thesis / dissertation: 2006
- Review: PROGRESS IN BRAIN RESEARCH. 2002;138:109-133
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Forskningsbidrag
- European Research Council1 April 2019 - 31 March 2024
Anställningar
- Senior Forskare, Medicinsk biokemi och biofysik, Karolinska Institutet, 2022-
Examina och utbildning
- Docent, Neurovetenskap, Karolinska Institutet, 2023
- MEDICINE DOKTORSEXAMEN, Institutionen för medicinsk biokemi och biofysik, Karolinska Institutet, 2006