Jens Hjerling-Leffler

About me
Publications
Grants
CV
Public outreach and news

About me

Associate Professor and Principle Investigator
Circuit maturation, neuronal diversity, mouse genetics, single-cell sequencing, transcriptional regulation, electrophysiology and
virus based tools.

Postdoc
2007-2011 Fishell lab, NYU Langone Medical Center, New York, NY, US
2006-2007 Koltzenburg lab, Queen Square Centre for Neuromuscular Disease, UCL,
London, UK

PhD
2006 Ernfors lab, Medical Biochemistry and Biophysics, Karolinska Institutet,
Sweden

Pre-PhD
Pfrieger lab, Max Delbrück Center for Molecular Medicine, Berlin, Germany

Research

Our research group is interested in the genetic and cellular mechanisms of postnatal and adolescent maturation and its role in psychiatric disorders. We apply advanced mouse genetics in combination with electrophysiology and modern molecular methods to probe and identify cellular changes and the function of individual cell types as well as study the circuit basis of their function.

Articles

Article: NEURON. 2023;111(22):3590-3603.e5
Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migration
Munguba H; Nikouei K; Hochgerner H; Oberst P; Kouznetsova A; Ryge J; Munoz-Manchado AB; Close J; Batista-Brito R; Linnarsson S; Hjerling-Leffler J
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2023;75:s85-s86
HIGHLIGHTING HUMAN BRAIN CELL TYPES AND REGIONS FOR THE GENETIC RISK OF SCHIZOPHRENIA AND OTHER PSYCHIATRIC DISORDERS
Yao S; Harder A; Darki F; Li A; Zeng J; Nikouei K; Lundstrom J; Wray N; Lu Y; Sullivan P; Hjerling-Leffler J
Journal article: IBRO REPORTS. 2023;15:s222
DECIPHERING THE ROLE OF THE NOVEL INTERNEURON POPULATION PTHLH IN THE MOUSE STRIATUM
Salguero MD; Harder L; Llorca-Torralba M; Herr M; Reyes JMB; Berrocoso E; Hjerling-Leffler J; Manchado AM
Article: BIOLOGY DIRECT. 2023;18(1):22
Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity
Adam AR; Martinez-Lopez JA; van der Spek SJF; Sullivan PF; Smit AB; Verhage M; Hjerling-Leffler J; Achsele T; Andres-Alonso M; Bagni C; Bayes A; Biederer T; Brose N; Chua JJE; Coba M; Cornelisse LN; de Juan-Sanz J; Goldschmidt HL; Gundelfinger ED; Huganir RL; Imig C; Jahn R; Jung H; Kaeser PS; Kim E; Koopmans F; Kreutz MR; Lipstein N; MacGillavry HD; McPherson PS; O'Connor V; Pielot R; Ryan TA; Sala C; Sheng M; Smalla K-H; Thomas PD; Toonen RF; van Weering JRT; Verhage M; Verpelli C
Article: STEM CELL REPORTS. 2023;18(1):337-353
Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation
Nishimura K; Yang S; Lee KW; Asgrimsdottir ES; Nikouei K; Paslawski W; Gnodde S; Lyu G; Hu L; Salto C; Svenningsson P; Hjerling-Leffler J; Linnarsson S; Arenas E
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2022;109(6):1077-1091
Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss
Trpchevska N; Freidin MB; Broer L; Oosterloo BC; Yao S; Zhou Y; Vona B; Bishop C; Bizaki-Vallaskangas A; Canlon B; Castellana F; Chasman DI; Cherny S; Christensen K; Concas MP; Correa A; Elkon R; Mengel-From J; Gao Y; Giersch ABS; Girotto G; Gudjonsson A; Gudnason V; Heard-Costa NL; Hertzano R; v.B. Hjelmborg J; Hjerling-Leffler J; Hoffman HJ; Kaprio J; Kettunen J; Krebs K; Kahler AK; Lallemend F; Launer LJ; Lee I-M; Leonard H; Li C-M; Lowenheim H; Magnusson PKE; van Meurs J; Milani L; Morton CC; Makitie A; Nalls MA; Nardone GG; Nygaard M; Palviainen T; Pratt S; Quaranta N; Ramo J; Saarentaus E; Sardone R; Satizabal CL; Schweinfurth JM; Seshadri S; Shiroma E; Shulman E; Simonsick E; Spankovich C; Tropitzsch A; Lauschke VM; Sullivan PF; Goedegebure A; Cederroth CR; Williams FMK; Nagtegaal AP
Journal article: BIOLOGICAL PSYCHIATRY. 2022;91(9):s293-s294
P508. Assessing Isoform Diversity in the Context of Psychiatric Disorders
Giusti-Rodriguez P; Abrantes A; Memic F; Dijkstra A; Ancalade N; Sekle S; Hjerling-Leffler J; Smit A; Sullivan P
Article: JOURNAL OF NEUROSCIENCE. 2021;41(43):8876-8886
Postnatal Sox6 Regulates Synaptic Function of Cortical Parvalbumin-Expressing Neurons
Munguba H; Chattopadhyaya B; Nilsson S; Carrico JN; Memic F; Oberst P; Batista-Brito R; Munoz-Manchado AB; Wegner M; Fishell G; Di Cristo G; Hjerling-Leffler J
Article: MOLECULAR PSYCHIATRY. 2021;26(6):2070-2081
Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders
Byrne EM; Zhu Z; Qi T; Skene NG; Bryois J; Pardinas AF; Stahl E; Smoller JW; Rietschel M; Owen MJ; Walters JTR; O'Donovan MC; McGrath JG; Hjerling-Leffler J; Sullivan PF; Goddard ME; Visscher PM; Yang J; Wray NR
Article: NATURE NEUROSCIENCE. 2020;23(12):1456-1468
A community-based transcriptomics classification and nomenclature of neocortical cell types
Yuste R; Hawrylycz M; Aalling N; Aguilar-Valles A; Arendt D; Arnedillo RA; Ascoli GA; Bielza C; Bokharaie V; Bergmann TB; Bystron I; Capogna M; Chang Y; Clemens A; de Kock CPJ; DeFelipe J; Dos Santos SE; Dunville K; Feldmeyer D; Fiath R; Fishell GJ; Foggetti A; Gao X; Ghaderi P; Goriounova NA; Guentuerkuen O; Hagihara K; Hall VJ; Helmstaedter M; Herculano S; Hilscher MM; Hirase H; Hjerling-Leffler J; Hodge R; Huang J; Huda R; Khodosevich K; Kiehn O; Koch H; Kuebler ES; Kuhnemund M; Larranaga P; Lelieveldt B; Louth EL; Lui JH; Mansvelder HD; Marin O; Martinez-Trujillo J; Moradi Chameh H; Nath A; Nedergaard M; Nemec P; Ofer N; Pfisterer UG; Pontes S; Redmond W; Rossier J; Sanes JR; Scheuermann R; Serrano-Saiz E; Steiger JF; Somogyi P; Tamas G; Tolias AS; Tosches MA; Garcia MT; Vieira HM; Wozny C; Wuttke TV; Yong L; Yuan J; Zeng H; Lein E
Article: SCIENTIFIC REPORTS. 2020;10(1):15680
Intrinsic electrophysiological properties predict variability in morphology and connectivity among striatal Parvalbumin-expressing Pthlh-cells
Gonzales CB; Hunt S; Munoz-Manchado AB; McBain CJ; Hjerling-Leffler J
Article: ELIFE. 2020;9:e59328
Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area
Nagaeva E; Zubarev I; Gonzales CB; Forss M; Nikouei K; de Miguel E; Elsila L; Linden A-M; Hjerling-Leffler J; Augustine GJ; Korpi ER
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2020;511:110835
Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels
Lindqvist A; Shcherbina L; Prasad RB; Miskelly MG; Abels M; Martinez-Lopez JA; Fred RG; Nergard BJ; Hedenbro J; Groop L; Hjerling-Leffler J; Wierup N
Article: NATURE GENETICS. 2020;52(5):482-493
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease
Bryois J; Skene NG; Hansen TF; Kogelman LJA; Watson HJ; Liu Z; Brueggeman L; Breen G; Bulik CM; Arenas E; Hjerling-Leffler J; Sullivan PF
Article: BMC BIOLOGY. 2020;18(1):6
Spatiotemporal mapping of RNA editing in the developing mouse brain using in situ sequencing reveals regional and cell-type-specific regulation
Lundin E; Wu C; Widmark A; Behm M; Hjerling-Leffler J; Daniel C; Ohman M; Nilsson M
Article: JOURNAL OF CELL BIOLOGY. 2020;219(1):e201905002
ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons
Gongrich C; Krapacher FA; Munguba H; Fernandez-Suarez D; Andersson A; Hjerling-Leffler J; Ibanez CF
Article: NATURE METHODS. 2020;17(1):101-106
Probabilistic cell typing enables fine mapping of closely related cell types in situ
Qian X; Harris KD; Hauling T; Nicoloutsopoulos D; Munoz-Manchado AB; Skene N; Hjerling-Leffler J; Nilsson M
Article: SCIENCE. 2019;365(6454):695-699
Specialized cutaneous Schwann cells initiate pain sensation
Abdo H; Calvo-Enrique L; Lopez JM; Song J; Zhang M-D; Usoskin D; El Manira A; Adameyko I; Hjerling-Leffler J; Ernfors P
Article: PLOS COMPUTATIONAL BIOLOGY. 2019;15(6):e1007113
Transcriptomic correlates of electrophysiological and morphological diversity within and across excitatory and inhibitory neuron classes
Bomkamp C; Tripathy SJ; Gonzales CB; Hjerling-Leffler J; Craig AM; Pavlidis P
Article: NATURE GENETICS. 2019;51(3):404-413
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Jansen IE; Savage JE; Watanabe K; Bryois J; Williams DM; Steinberg S; Sealock J; Karlsson IK; Hagg S; Athanasiu L; Voyle N; Proitsi P; Witoelar A; Stringer S; Aarsland D; Almdahl IS; Andersen F; Bergh S; Bettella F; Bjornsson S; Braekhus A; Brathen G; de Leeuw C; Desikan RS; Djurovic S; Dumitrescu L; Fladby T; Hohman TJ; Jonsson PV; Kiddle SJ; Rongve A; Saltvedt I; Sando SB; Selbaek G; Shoai M; Skene NG; Snaedal J; Stordal E; Ulstein ID; Wang Y; White LR; Hardy J; Hjerling-Leffler J; Sullivan PF; van der Flier WM; Dobson R; Davis LK; Stefansson H; Stefansson K; Pedersen NL; Ripke S; Andreassen OA; Posthuma D
Article: NATURE GENETICS. 2019;51(3):394-403
Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways
Jansen PR; Watanabe K; Stringer S; Skene N; Bryois J; Hammerschlag AR; de Leeuw CA; Benjamins JS; Munoz-Manchado AB; Nagel M; Savage JE; Tiemeier H; White T; Tung JY; Hinds DA; Vacic V; Wang X; Sullivan PF; van der Sluis S; Polderman TJC; Smit AB; Hjerling-Leffler J; Van Someren EJW; Posthuma D; Agee M; Alipanahi B; Auton A; Bell RK; Bryc K; Elson SL; Fontanillas P; Furlotte NA; Huber KE; Kleinman A; Litterman NK; McCreight JC; McIntyre MH; Mountain JL; Noblin ES; Northover CAM; Pitts SJ; Sathirapongsasuti JF; Sazonova OV; Shelton JF; Shringarpure S; Tian C; Wilson CH
Article: MOLECULAR PSYCHIATRY. 2019;24(2):182-197
Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals
Coleman JRI; Bryois J; Gaspar HA; Jansen PR; Savage JE; Skene N; Plomin R; Munoz-Manchado AB; Linnarsson S; Crawford G; Hjerling-Leffler J; Sullivan PF; Posthuma D; Breen G
Article: CELL REPORTS. 2018;24(8):2179-2190.e7
Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq
Munoz-Manchado AB; Gonzales CB; Zeisel A; Munguba H; Bekkouche B; Skene NG; Lonnerberg P; Ryge J; Harris KD; Linnarsson S; Hjerling-Leffler J
Article: DEVELOPMENTAL CELL. 2018;46(4):504-517.e7
Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development
Marques S; van Bruggen D; Vanichkina DP; Floriddia EM; Munguba H; Varemo L; Giacomello S; Falcao AM; Meijer M; Bjorklund AK; Hjerling-Leffler J; Taft RJ; Castelo-Branco G
Article: CELL. 2018;174(4):999-1014.e22
Molecular Architecture of the Mouse Nervous System
Zeisel A; Hochgerner H; Lonnerberg P; Johnsson A; Memic F; van der Zwan J; Haring M; Braun E; Borm LE; La Manno G; Codeluppi S; Furlan A; Lee K; Skene N; Harris KD; Hjerling-Leffler J; Arenas E; Ernfors P; Marklund U; Linnarsson S
Article: NATURE GENETICS. 2018;50(7):912-919
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Savage JE; Jansen PR; Stringer S; Watanabe K; Bryois J; de Leeuw CA; Nagel M; Awasthi S; Barr PB; Coleman JRI; Grasby KL; Hammerschlag AR; Kaminski JA; Karlsson R; Krapohl E; Lam M; Nygaard M; Reynolds CA; Trampush JW; Young H; Zabaneh D; Hagg S; Hansell NK; Karlsson IK; Linnarsson S; Montgomery GW; Munoz-Manchado AB; Quinlan EB; Schumann G; Skene NG; Webb BT; White T; Arking DE; Avramopoulos D; Bilder RM; Bitsios P; Burdick KE; Cannon TD; Chiba-Falek O; Christoforou A; Cirulli ET; Congdon E; Corvin A; Davies G; Deary IJ; DeRosse P; Dickinson D; Djurovic S; Donohoe G; Conley ED; Eriksson JG; Espeseth T; Freimer NA; Giakoumaki S; Giegling I; Gill M; Glahn DC; Hariri AR; Hatzimanolis A; Keller MC; Knowles E; Koltai D; Konte B; Lahti J; Le Hellard S; Lencz T; Liewald DC; London E; Lundervold AJ; Malhotra AK; Melle I; Morris D; Need AC; Ollier W; Palotie A; Payton A; Pendleton N; Poldrack RA; Raikkonen K; Reinvang I; Roussos P; Rujescu D; Sabb FW; Scult MA; Smeland OB; Smyrnis N; Starr JM; Steen VM; Stefanis NC; Straub RE; Sundet K; Tiemeier H; Voineskos AN; Weinberger DR; Widen E; Yu J; Abecasis G; Andreassen OA; Breen G; Christiansen L; Debrabant B; Dick DM; Heinz A; Hjerling-Leffler J; Ikram MA; Kendler KS; Martin NG; Medland SE; Pedersen NL; Plomin R; Polderman TJC; Ripke S; van der Sluis S; Sullivan PF; Vrieze SI; Wright MJ; Posthuma D
Article: NATURE GENETICS. 2018;50(7):920-927
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways
Nagel M; Jansen PR; Stringer S; Watanabe K; de Leeuw CA; Bryois J; Savage JE; Hammerschlag AR; Skene NG; Munoz-Manchado AB; White T; Tiemeier H; Linnarsson S; Hjerling-Leffler J; Polderman TJC; Sullivan PF; van der Sluis S; Posthuma D
Article: PLOS BIOLOGY. 2018;16(6):e2006387
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics
Harris KD; Hochgerner H; Skene NG; Magno L; Katona L; Gonzales CB; Somogyi P; Kessaris N; Linnarsson S; Hjerling-Leffler J
Article: NATURE GENETICS. 2018;50(6):825-833
Genetic identification of brain cell types underlying schizophrenia
Skene NG; Bryois JD; Bakken TE; Breen GP; Crowley JJ; Gaspar HA; Giusti-Rodriguez PC; Hodge RD; Miller JA; Munoz-Manchado AB; O'Donovan MC; Owen MJ; Pardinas AF; Ryge JP; Walters JT; Linnarsson S; Lein ES; Sullivan PF; Hjerling-Leffler JC
Article: JOURNAL OF NEUROENDOCRINOLOGY. 2018;30(3):e12573
Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area
Harder L; Dudazy-Gralla S; Mueller-Fielitz H; Leffler JH; Vennstrom B; Heuer H; Mittag J
Article: GASTROENTEROLOGY. 2018;154(3):624-636
Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System
Memic F; Knoflach V; Morarach K; Sadler R; Laranjeira C; Hjerling-Leffler J; Sundstrom E; Pachnis V; Marklund U
Article: GENOME MEDICINE. 2017;9(1):114
Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders
Nguyen HT; Bryois J; Kim A; Dobbyn A; Huckins LM; Munoz-Manchado AB; Ruderfer DM; Genovese G; Fromer M; Xu X; Pinto D; Linnarsson S; Verhage M; Smit AB; Hjerling-Leffler J; Buxbaum JD; Hultman C; Sklar P; Purcell SM; Lage K; He X; Sullivan PF; Stahl EA
Article: SCIENCE. 2017;356(6343):1168-1171
miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes
Peng C; Li L; Zhang M-D; Gonzales CB; Parisien M; Belfer I; Usoskin D; Abdo H; Furlan A; Haring M; Lallemend F; Harkany T; Diatchenko L; Hokfelt T; Hjerling-Leffler J; Ernfors P
Article: SCIENCE. 2016;352(6291):1326-1329
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Marques S; Zeisel A; Codeluppi S; van Bruggen D; Falcao AM; Xiao L; Li H; Haring M; Hochgerner H; Romanov RA; Gyllborg D; Munoz-Manchado AB; La Manno G; Lonnerberg P; Floriddia EM; Rezayee F; Ernfors P; Arenas E; Hjerling-Leffler J; Harkany T; Richardson WD; Linnarsson S; Castelo-Branco G
Article: CEREBRAL CORTEX. 2016;26(1):96-105
Novel Striatal GABAergic Interneuron Populations Labeled in the 5HT3a^EGFP Mouse
Munoz-Manchado AB; Foldi C; Szydlowski S; Sjulson L; Farries M; Wilson C; Silberberg G; Hjerling-Leffler J
Article: JOURNAL OF CHEMICAL NEUROANATOMY. 2016;71:1-5
BCL11B/CTIP2 is highly expressed in GABAergic interneurons of the mouse somatosensory cortex
Nikouei K; Munoz-Manchado AB; Hjerling-Leffler J
Article: SCIENCE. 2015;347(6226):1138-1142
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Zeisel A; Munoz-Manchado AB; Codeluppi S; Lonnerberg P; La Manno G; Jureus A; Marques S; Munguba H; He L; Betsholtz C; Rolny C; Castelo-Branco G; Hjerling-Leffler J; Linnarsson S
Article: NATURE NEUROSCIENCE. 2015;18(1):145-153
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Usoskin D; Furlan A; Islam S; Abdo H; Lonnerberg P; Lou D; Hjerling-Leffler J; Haeggstrom J; Kharchenko O; Kharchenko PV; Linnarsson S; Ernfors P
Article: NEUROBIOLOGY OF DISEASE. 2013;49:118-127
Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens
Ribeiro D; Goya RL; Ravindran G; Vuono R; Parish CL; Foldi C; Piroth T; Yang S; Parmar M; Nikkhah G; Hjerling-Leffler J; Lindvall O; Barker RA; Arenas E
Article: FRONTIERS IN NEURAL CIRCUITS. 2012;6:44
The origin of neocortical nitric oxide synthase-expressing inhibitory neurons
Jaglin XH; Hjerling-Leffler J; Fishell G; Batista-Brito R
Article: DEVELOPMENTAL NEUROBIOLOGY. 2011;71(1):45-61
Three Groups of Interneurons Account for Nearly 100% of Neocortical GABAergic Neurons
Rudy B; Fishell G; Lee S; Hjerling-Leffler J
Article: JOURNAL OF NEUROSCIENCE. 2010;30(50):16796-16808
The Largest Group of Superficial Neocortical GABAergic Interneurons Expresses Ionotropic Serotonin Receptors
Lee S; Hjerling-Leffler J; Zagha E; Fishell G; Rudy B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(37):16336-16341
En masse in vitro functional profiling of the axonal mechanosensitivity of sensory neurons
Usoskin D; Zilberter M; Linnarsson S; Hjerling-Leffler J; Uhlen P; Harkany T; Ernfors P
Article: JOURNAL OF NEUROSCIENCE. 2010;30(5):1582-1594
Genetic Fate Mapping Reveals That the Caudal Ganglionic Eminence Produces a Large and Diverse Population of Superficial Cortical Interneurons
Miyoshi G; Hjerling-Leffler J; Karayannis T; Sousa VH; Butt SJB; Battiste J; Johnson JE; Machold RP; Fishell G
Article: NEURON. 2009;63(4):466-481
The Cell-Intrinsic Requirement of Sox6 for Cortical Interneuron Development
Batista-Brito R; Rossignol E; Hjerling-Leffler J; Denaxa M; Wegner M; Lefebvre V; Pachnis V; Fishell G
Article: STEM CELLS. 2009;27(7):1592-1603
Regulation of Boundary Cap Neural Crest Stem Cell Differentiation After Transplantation
Aldskogius H; Berens C; Kanaykina N; Liakhovitskaia A; Medvinsky A; Sandelin M; Schreiner S; Wegner M; Hjerling-Leffler J; Kozlova EN
Article: CEREBRAL CORTEX. 2009;19(Suppl 1):i1-10
Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages
Sousa VH; Miyoshi G; Hjerling-Leffler J; Karayannis T; Fishell G
Article: BEHAVIOURAL BRAIN RESEARCH. 2009;197(2):339-346
Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice
Zhu S-W; Codita A; Bogdanovic N; Hjerling-Leffler J; Ernfors P; Winblad B; Dickins DW; Mohammed AH
Article: NEURON. 2008;59(5):722-732
The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes
Butt SJB; Sousa VH; Fuccillo MV; Hjerling-Leffler J; Miyoshi G; Kimura S; Fishell G
Article: NATURE. 2008;451(7177):460-4U4
Histone H2AX-dependent GABA_A receptor regulation of stem cell proliferation
Andang M; Hjerling-Leffler J; Moliner A; Lundgren TK; Castelo-Branco G; Nanou E; Pozas E; Bryja V; Halliez S; Nishimaru H; Wilbertz J; Arenas E; Koltzenburg M; Charnay P; El Manira A; Ibanez CF; Ernfors P
Article: JOURNAL OF NEUROSCIENCE. 2007;27(10):2435-2443
Emergence of functional sensory subtypes as defined by transient receptor potential channel expression
Hjerling-Leffler J; AlQatari M; Ernfors P; Koltzenburg M
Journal article: EUROPEAN JOURNAL OF PAIN. 2006;10(S1):s7d-ss8
26 GENE TARGETING WITH RNAI IN PRIMARY SENSORY NEURONS: FROM SIRNA DESIGN TO PHYSIOLOGICAL EFFECT
Usoskin D; Aquino J; Hjerling‐Leffler J; Maxvall I; Ernfors P
Article: EXPERIMENTAL NEUROLOGY. 2006;198(2):438-449
In vitro and in vivo differentiation of boundary cap neural crest stem cells into mature Schwann cells
Aquino JB; Hjerling-Leffler J; Koltzenburg M; Edlund T; Villar MJ; Ernfors P
Article: CELL AND TISSUE RESEARCH. 2006;323(1):81-90
Increased progenitor proliferation and apoptotic cell death in the sensory lineage of mice overexpressing N-myc
Kobayashi M; Hjerling-Leffler J; Ernfors P
Article: DEVELOPMENT. 2005;132(11):2623-2632
The boundary cap:: a source of neural crest stem cells that generate multiple sensory neuron subtypes
Hjerling-Leffler J; Marmigère F; Heglind M; Cederberg A; Koltzenburg M; Enerbäck S; Ernfors P
Article: DEVELOPMENT. 2003;130(8):1479-1491
BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development
Agerman K; Hjerling-Leffler J; Blanchard MP; Scarfone E; Canlon B; Nosrat C; Ernfors P
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All other publications

Preprint: MEDRXIV. 2024;MEDRXIV
Distinct genomic signatures and modifiable risk factors underly the comorbidity between major depressive disorder and cardiovascular disease.
Bergstedt J; Pasman JA; Ma Z; Harder A; Yao S; Parker N; Treur JL; Smit DJA; Frei O; Shadrin A; Meijsen JJ; Shen Q; Hägg S; Tornvall P; Buil A; Werge T; Hjerling-Leffler J; Als TD; Børglum AD; Lewis CM; McIntosh AM; Valdimarsdóttir UA; Andreassen OA; Sullivan PF; Lu Y; Fang F
Preprint: MEDRXIV. 2024;MEDRXIV
Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity.
Yao S; Harder A; Darki F; Chang Y-W; Li A; Nikouei K; Volpe G; Lundström JN; Zeng J; Wray N; Lu Y; Sullivan PF; Leffler JH
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2023;75:S85
IDENTIFICATION OF CELL TYPES AND CELLULAR DYNAMICS GENETICALLY ASSOCIATED WITH BRAIN DISORDERS AND COGNITIVE TRAITS
Yao S; Harder A; Darki F; Li A; Zeng J; Nikouei K; Lundstrom J; Wray N; Lu Y; Sullivan P; Hjerling-Leffler J
Preprint: BIORXIV. 2023
Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes
Martínez-López JA; Lindqvist A; Lopez-Pascual A; Chen P; Shcherbina L; Chriett S; Skene NG; Prasad RB; Lancien M; Johnson PF; Eliasson P; Louvet C; Muñoz-Manchado AB; Sandberg R; Hjerling-Leffler J; Wierup N
Preprint: BIORXIV. 2022
Transcriptional diversity in synaptic gene sets is sufficient to discriminate cortical neuronal identity
Adam AR; López JM; van der Spek S; The SYNGO consortium; Sullivan P; Smit A; Verhage M; Hjerling-Leffler J
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:E156
DIFFERENTIAL ISOFORM USAGE IN SCHIZOPHRENIA
Abrantes A; Ancalade N; Sekle S; Memic F; Dijkstra A; Tseng E; Sheynkman G; Hjerling-Leffler J; Smit A; Sullivan P; Giusti-Rodriguez P
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:E66-E67
BRAIN CELL TYPE SPECIFIC EQTLS AND SCHIZOPHRENIA
Yao S; Bast L; Martinez-Lopez J; Memic F; Wray N; Sullivan P; Hjerling-Leffler J
Preprint: BIORXIV. 2022
Single cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation
Nishimura K; Yang S; Lee KW; Ásgrímsdóttir ES; Nikouei K; Paslawski W; Gnodde S; Lyu G; Hu L; Saltó C; Svenningsson P; Hjerling-Leffler J; Linnarsson S; Arenas E
Conference publication: BIOLOGICAL PSYCHIATRY. 2022;91(9):S293-S294
Assessing Isoform Diversity in the Context of Psychiatric Disorders
Giusti-Rodriguez P; Abrantes A; Memic F; Dijkstra A; Ancalade N; Sekle S; Hjerling-Leffler J; Smit A; Sullivan P
Editorial comment: CURRENT OPINION IN GENETICS AND DEVELOPMENT. 2021;68:III-IX
Editorial overview: Rare CNV disorders and neuropsychiatric phenotypes: opportunities, challenges, solutions
Mulle JG; Sullivan PF; Hjerling-Leffler J
Corrigendum: NATURE NEUROSCIENCE. 2021;24(4):613
Publisher Correction: A community-based transcriptomics classification and nomenclature of neocortical cell types.
Yuste R; Hawrylycz M; Aalling N; Aguilar-Valles A; Arendt D; Arnedillo RA; Ascoli GA; Bielza C; Bokharaie V; Bergmann TB; Bystron I; Capogna M; Chang Y; Clemens A; de Kock CPJ; DeFelipe J; Dos Santos SE; Dunville K; Feldmeyer D; Fiáth R; Fishell GJ; Foggetti A; Gao X; Ghaderi P; Goriounova NA; Güntürkün O; Hagihara K; Hall VJ; Helmstaedter M; Herculano S; Hilscher MM; Hirase H; Hjerling-Leffler J; Hodge R; Huang J; Huda R; Khodosevich K; Kiehn O; Koch H; Kuebler ES; Kühnemund M; Larrañaga P; Lelieveldt B; Louth EL; Lui JH; Mansvelder HD; Marin O; Martinez-Trujillo J; Moradi Chameh H; Nath A; Nedergaard M; Němec P; Ofer N; Pfisterer UG; Pontes S; Redmond W; Rossier J; Sanes JR; Scheuermann R; Serrano-Saiz E; Steiger JF; Somogyi P; Tamás G; Tolias AS; Tosches MA; García MT; Vieira HM; Wozny C; Wuttke TV; Yong L; Yuan J; Zeng H; Lein E
Corrigendum: NATURE NEUROSCIENCE. 2021;24(4):612
Author Correction: A community-based transcriptomics classification and nomenclature of neocortical cell types.
Yuste R; Hawrylycz M; Aalling N; Aguilar-Valles A; Arendt D; Armañanzas R; Ascoli GA; Bielza C; Bokharaie V; Bergmann TB; Bystron I; Capogna M; Chang Y; Clemens A; de Kock CPJ; DeFelipe J; Dos Santos SE; Dunville K; Feldmeyer D; Fiáth R; Fishell GJ; Foggetti A; Gao X; Ghaderi P; Goriounova NA; Güntürkün O; Hagihara K; Hall VJ; Helmstaedter M; Herculano-Houzel S; Hilscher MM; Hirase H; Hjerling-Leffler J; Hodge R; Huang J; Huda R; Khodosevich K; Kiehn O; Koch H; Kuebler ES; Kühnemund M; Larrañaga P; Lelieveldt B; Louth EL; Lui JH; Mansvelder HD; Marin O; Martinez-Trujillo J; Chameh HM; Mohapatra AN; Munguba H; Nedergaard M; Němec P; Ofer N; Pfisterer UG; Pontes S; Redmond W; Rossier J; Sanes JR; Scheuermann RH; Serrano-Saiz E; Staiger JF; Somogyi P; Tamás G; Tolias AS; Tosches MA; García MT; Wozny C; Wuttke TV; Liu Y; Yuan J; Zeng H; Lein E
Conference publication: DIABETOLOGIA. 2021;64(SUPPL 1):8
The transcription factor CEBPG regulates beta cell function
Lopez-Pascual A; Lindqvist A; Martinez-Lopez JA; Hjerling-Leffler J; Wierup N
Preprint: BIORXIV. 2020
Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area
Nagaeva E; Zubarev I; Gonzales CB; Forss M; Nikouei K; de Miguel E; Elsilä L; Linden A-M; Hjerling-Leffler J; Augustine GJ; Korpi ER
Corrigendum: NATURE GENETICS. 2020;52(3):354
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk (vol 51, 404, 2019)
Jansen IE; Savage JE; Watanabe K; Bryois J; Williams DM; Steinberg S; Sealock J; Karlsson IK; Haegg S; Athanasiu L; Voyle N; Proitsi P; Witoelar A; Stringer S; Aarsland D; Almdahl IS; Andersen F; Bergh S; Bettella F; Bjornsson S; Braekhus A; Brathen G; de Leeuw C; Desikan RS; Djurovic S; Dumitrescu L; Fladby T; Hohman TJ; Jonsson PV; Kiddle SJ; Rongve A; Saltvedt I; Sando SB; Selbaek G; Shoai M; Skene NG; Snaedal J; Stordal E; Ulstein ID; Wang Y; White LR; Hardy J; Hjerling-Leffler J; Sullivan PF; van der Flier WM; Dobson R; Davis LK; Stefansson H; Stefansson K; Pedersen NL; Ripke S; Andreassen OA; Posthuma D
Preprint: BIORXIV. 2019
Activin receptor ALK4 coordinates extracellular signals and intrinsic transcriptional programs to regulate development of cortical somatostatin interneurons
Göngrich C; Krapacher FA; Munguba H; Fernández-Suárez D; Andersson A; Hjerling-Leffler J; Ibáñez CF
Preprint: ARXIV. 2019
A community-based transcriptomics classification and nomenclature of neocortical cell types
Yuste R; Hawrylycz M; Aalling N; Arendt D; Armananzas R; Ascoli G; Bielza C; Bokharaie V; Bergmann T; Bystron I; Capogna M; Chang Y; Clemens A; de Kock C; DeFelipe J; Santos SD; Dunville K; Feldmeyer D; Fiath R; Fishell G; Foggetti A; Gao X; Ghaderi P; Gunturkun O; Hall VJ; Helmstaedter M; Herculano-Houzel S; Hilscher M; Hirase H; Hjerling-Leffler J; Hodge R; Huang ZJ; Huda R; Juan Y; Khodosevich K; Kiehn O; Koch H; Kuebler E; Kuhnemund M; Larranaga P; Lelieveldt B; Louth EL; Lui J; Mansvelder H; Marin O; Martínez-Trujillo J; Moradi H; Goriounova N; Mohapatra A; Nedergaard M; Němec P; Ofer N; Pfisterer U; Pontes S; Redmond W; Rossier J; Sanes J; Scheuermann R; Saiz ES; Somogyi P; Tamás G; Tolias A; Tosches M; Garcia MT; Aguilar-Valles A; Munguba H; Wozny C; Wuttke T; Yong L; Zeng H; Lein ES
Preprint: BIORXIV. 2019
Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migration
Munguba H; Nikouei K; Hochgerner H; Oberst P; Kouznetsova A; Ryge J; Batista-Brito R; Munoz-Manchado AB; Close J; Linnarsson S; Hjerling-Leffler J
Preprint: BIORXIV. 2019
Conditional GWAS analysis identifies putative disorder-specific SNPs for psychiatric disorders
Byrne EM; Zhu Z; Qi T; Skene NG; Bryois J; Pardinas AF; Stahl E; Smoller JW; Rietschel M; Consortium BWGOTPG; Consortium MDDWGOT; Owen MJ; Walters JTR; O’Donovan MC; McGrath JG; Hjerling-Leffler J; Sullivan PF; Goddard ME; Visscher PM; Yang J; Wray NR
Preprint: BIORXIV. 2019
Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s Disease
Bryois J; Skene NG; Hansen TF; Kogelman L; Watson HJ; Liu Z; Consortium EDWGOTP; Consortium IHG; Team AR; Brueggeman L; Breen G; Bulik CM; Arenas E; Hjerling-Leffler J; Sullivan PF
Preprint: BIORXIV. 2019
Transcriptomic correlates of electrophysiological and morphological diversity within and across neuron types
Bomkamp C; Tripathy S; Bengtsson Gonzales C; Hjerling Leffler J; Craig AM; Pavlidis P
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:1104-1105
GENOME-WIDE ANALYSIS OF INSOMNIA AND SLEEP-RELATED TRAITS IN OVER 1 MILLION INDIVIDUALS IDENTIFIES NOVEL GENES AND PATHWAYS
Jansen P; Watanabe K; Stringer S; Skene N; Bryois J; Munoz-Manchado A; Tung J; Hinds D; Vacic V; Sullivan P; Polderman T; Smit A; Hjerling-Leffler J; van Someren E; Posthuma D
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S809-S810
FUNCTIONAL CONSEQUENCES OF GENETIC LOCI ASSOCIATED WITH IQ IN A META-ANALYSIS OF 87,740 INDIVIDUALS
Coleman J; Bryois J; Gaspar H; Jansen P; Savage J; Skene N; Plomin R; Hjerling-Leffler J; Sullivan P; Posthuma D; Breen G
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S799
GENETIC IDENTIFICATION OF BRAIN CELL TYPES UNDERLYING SCHIZOPHRENIA
Bryois J; Skene N; Bakken T; Breen G; Crowley J; Gaspar HA; Giusti-Rodriguez P; O'Donovan M; Owen M; Walters J; Linnarsson S; Lein E; Sullivan P; Hjerling-Leffler J
Preprint: BIORXIV. 2018
A spatial atlas of inhibitory cell types in mouse hippocampus
Qian X; Harris KD; Hauling T; Nicoloutsopoulos D; Muñoz-Manchado AB; Skene N; Hjerling-Leffler J; Nilsson M
Preprint: BIORXIV. 2018
Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes
Nguyen H; Dobbyn A; Charney A; Bryois J; Kim A; Mcfadden W; Skene N; Huckins L; Wang W; Ruderfer D; Xu X; Fromer M; Purcell S; Lage K; Verhage M; Smit A; Hjerling-Leffler J; Buxbaum J; Pinto D; He X; Sullivan P; Stahl E
Preprint: BIORXIV. 2018
Molecular architecture of the mouse nervous system
Zeisel A; Hochgerner H; Lönnerberg P; Johnsson A; Memic F; van der Zwan J; Häring M; Braun E; Borm L; La Manno G; Codeluppi S; Furlan A; Skene N; Harris K; Hjerling Leffler J; Arenas E; Ernfors P; Marklund U; Linnarsson S
Preprint: BIORXIV. 2018
Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease risk
Jansen I; Savage J; Watanabe K; Bryois J; Williams D; Steinberg S; Sealock J; Karlsson I; Hägg S; Athanasiu L; Voyle N; Proitsi P; Witoelar A; Stringer S; Aarsland D; Almdahl I; Andersen F; Bergh S; Bettella F; Bjornsson S; Brækhus A; Bråthen G; de Leeuw C; Desikan R; Djurovic S; Dumitrescu L; Fladby T; Homan T; Jonsson P; Kiddle S; Rongve A; Saltvedt I; Sando S; Selbæk G; Skenne N; Snaedal J; Stordal E; Ulstein I; Wang Y; White L; Hjerling-Leffler J; Sullivan P; van der Flier W; Dobson R; Davis L; Stefansson H; Stefansson K; Pedersen N; Ripke S; Andreassen O; Posthuma D
Preprint: BIORXIV. 2018
Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways
Jansen P; Watanabe K; Stringer S; Skene N; Bryois J; Hammerschlag A; de Leeuw C; Benjamins J; Muñoz-Manchado A; Nagel M; Savage J; Tiemeier H; White T; The 23andMe Research Team; Tung J; Hinds D; Vacic V; Sullivan P; van der Sluis S; Polderman TJC; Smit A; Hjerling-Leffler J; Van Someren EJW; Posthuma D
Conference publication: DIABETOLOGIA. 2018;61:S117-S118
Type 2 diabetes-induced beta cell gene regulatory networks identified using single-cell RNA-sequencing of human islets
Wierup N; Martinez-Lopez JA; Lindqvist A; Fred RG; Munoz-Manchado AB; Chriett S; Shcherbina L; Hjerling-Leffler J
Conference publication: JOURNAL OF SLEEP RESEARCH. 2018;27
Genome-wide analysis of insomnia in UK Biobank and 23andMe identifies novel loci and functional pathways
Jansen P; Watanabe K; Stringer S; Skene N; Bryois J; Benjamins J; Munoz-Manchado A; Tung J; Hinds D; Vacic V; Sullivan P; Polderman T; Smit A; Hjerling-Leffler J; van Someren E; Posthuma D
Conference publication: HUMAN GENOMICS. 2018;12
GWAS meta-analysis (N=279,930) identifies new genes and functional links to general cognitive ability
Savage JE; Jansen PR; Stringer S; Watanabe K; Bryois J; de Leeuw CA; Nagel M; Awasthi S; Barr PB; Coleman JRI; Grasby KL; Hammerschlag AR; Kaminski J; Karlsson R; Krapohl E; Lam M; Nygaard M; Reynolds CA; Trampush JW; Young H; Zabaneh D; Hagg S; Hansell NK; Karlsson IK; Linnarsson S; Montgomery GW; Munoz-Manchado AB; Quinlan EB; Schumann G; Skene N; Webb BT; White T; Arking DE; Attix DK; Avramopoulos D; Bilder RM; Bitsios P; Burdick KE; Cannon TD; Chiba-Falek O; Christoforou A; Cirulli ET; Congdon E; Corvin A; Davies G; Deary IJ; DeRosse P; Dickinson D; Djurovic S; Donohoe G; Conley ED; Eriksson JG; Espeseth T; Freimer NA; Giakoumaki S; Giegling I; Gill M; Glahn DC; Hariri AR; Hatzimanolis A; Keller MC; Knowles E; Konte B; Lahti J; Le Hellard S; Lencz T; Liewald DC; London E; Lundervold AJ; Malhotra AK; Melle I; Morris D; Need AC; Ollier W; Palotie A; Payton A; Pendleton N; Poldrack RA; Raikkonen K; Reinvang I; Roussos P; Rujescu D; Sabb FW; Scult MA; Smeland OB; Smyrnis N; Starr JM; Steen VM; Stefanis NC; Straub RE; Sundet K; Voineskos AN; Weinberger DR; Widen E; Yu J; Abecasis G; Andreassen OA; Breen G; Christiansen L; Debrabant B; Dick DM; Heinz A; Hjerling-Leffler J; Ikram MA; Kendler KS; Martin NG; Medland SE; Pedersen NL; Plomin R; Polderman TJC; Ripke S; van der Sluis S; Sullivan PF; Tiemeier H; Vrieze SI; Wright MJ; Posthuma D
Preprint: BIORXIV. 2017
Single-cell transcriptomic profiling of progenitors of the oligodendrocyte lineage reveals transcriptional convergence during development
Marques S; Vanichkina D; van Bruggen D; Floriddia E; Munguba H; Väremo L; Giacomello S; Mendanha Falcão A; Meijer M; Samudyata S; Codeluppi S; Björklund Å; Linnarsson S; Hjerling-Leffler J; Taft R; Castelo-Branco G
Preprint: BIORXIV. 2017
GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence
Savage J; Jansen P; Stringer S; Watanabe K; Bryois J; de Leeuw C; Nagel M; Awasthi S; Barr P; Coleman J; Grasby K; Hammerschlag A; Kaminski J; Karlsson R; Krapohl E; Lam M; Nygaard M; Reynolds C; Trampush J; Young H; Zabaneh D; Hägg S; Hansell N; Karlsson I; Linnarsson S; Montgomery G; Muñoz-Manchado A; Quinlan E; Schumann G; Skene N; Webb B; White T; Arking D; Attix D; Avramopoulos D; Bilder R; Bitsios P; Burdick K; Cannon T; Chiba-Falek O; Christoforou A; Cirulli E; Congdon E; Corvin A; Davies G; Deary I; DeRosse P; Dickinson D; Djurovic S; Donohoe G; Conley ED; Eriksson J; Espeseth T; Freimer N; Giakoumaki S; Giegling I; Gill M; Glahn D; Hariri A; Hatzimanolis A; Keller M; Knowles E; Konte B; Lahti J; Hellard SL; Lencz T; Liewald D; London E; Lundervold A; Malhotra A; Melle I; Morris D; Need A; Ollier W; Palotie A; Payton A; Pendleton N; Poldrack R; Räikkönen K; Reinvang I; Roussos P; Rujescu D; Sabb F; Scult M; Smeland O; Smyrnis N; Starr J; Steen V; Stefanis N; Straub R; Sundet K; Voineskos A; Weinberger D; Widen E; Yu J; Abecasis G; Andreassen O; Breen G; Christiansen L; Debrabant B; Dick D; Heinz A; Hjerling-Leffler J; Ikram A; Kendler K; Martin N; Medland S; Pedersen N; Plomin R; Polderman TJC; Ripke S; Sluis SVD; Sullivan P; Tiemeier H; Vrieze S; Wright M; Posthuma D
Preprint: BIORXIV. 2017
GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways
Nagel M; Jansen P; Stringer S; Watanabe K; de Leeuw C; Bryois J; Savage J; Hammerschlag A; Skene N; Muñoz-Manchado A; the 23andMe Research Team; Linnarsson S; Hjerling-Leffler J; White TJH; Tiemeier H; Polderman TJC; Sullivan P; van der Sluis S; Posthuma D
Preprint: BIORXIV. 2017
Functional consequences of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals
Coleman J; Bryois J; Gaspar H; Jansen P; Savage J; Skene N; Plomin R; Muñoz-Manchado A; Linnarsson S; Crawford G; Hjerling-Leffler J; Sullivan P; Posthuma D; Breen G
Conference publication: MECHANISMS OF DEVELOPMENT. 2017;145:S122
Sox6, a regulatory gene in the specification of gastric dopaminergic neurons
Memic F; Knoflach V; Sadler R; Laranjeira C; Lefebvre V; Hjerling-Leffler J; Sundstrom E; Pachnis V; Marklund U
Preprint: BIORXIV. 2017
Genetic identification Of brain cell types underlying schizophrenia
Skene N; Bryois J; Bakken T; Breen G; Crowley J; A Gaspar H; Giusti-Rodriguez P; Hodge R; Miller J; Muñoz-Manchado A; O’Donovan M; Owen M; Pardiñas A; Ryge J; Walters J; Linnarsson S; Lein E; Major Depressive Disorder Working Group of the Psy; Sullivan P; Hjerling-Leffler J
Preprint: BIORXIV. 2017
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics
Harris K; Hochgerner H; Skene N; Magno L; Katona L; Gonzales CB; Somogyi P; Kessaris N; Linnarsson S; Hjerling-Leffler J
Preprint: BIORXIV. 2017
Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders
Nguyen H; Bryois J; Kim A; Dobbyn A; Huckins L; Munoz-Manchado A; Ruderfer D; Genovese G; Fromer M; Xu X; Pinto D; Linnarsson S; Verhage M; Smit A; Hjerling-Leffler J; Buxbaum J; Hultman C; Sklar P; Purcell S; Lage K; He X; Sullivan P; Stahl E
Conference publication: DIABETOLOGIA. 2017;60:S67
Multiple type 2 diabetes genes identified using single-cell RNA-seq of human islets
Wierup N; Martinez-Lopez JA; Fred RG; Munoz-Manchado A; Hjerling-Leffler J
Review: NATURE NEUROSCIENCE. 2016;19(9):1131-1141
Disentangling neural cell diversity using single-cell transcriptomics
Poulin J-F; Tasic B; Hjerling-Leffler J; Trimarchi JM; Awatramani R
Preprint: BIORXIV. 2015
Molecular organization of CA1 interneuron classes
Harris K; Magno L; Katona L; Lönnerberg P; Muñoz Manchado A; Somogyi P; Kessaris N; Linnarsson S; Hjerling-Leffler J
Conference publication: GLIA. 2015;63:E191
Single-cell transcriptomics of the oligodendrocyte lineage in the mouse brain
Marques S; Zeisel A; Samudyata S; Vanichkina D; Manchado AM; Codeluppi S; Taft R; Hjerling-Leffler J; Linnarsson S; Castelo-Branco G
Review: JOURNAL OF PHYSIOLOGY. 2012;590(4):703-714
Sticking out of the crowd: the molecular identity and development of cholecystokinin-containing basket cells
Keimpema E; Straiker A; Mackie K; Harkany T; Hjerling-Leffler J
Conference publication: JOURNAL OF NEUROCHEMISTRY. 2009;108:1
THE DEVELOPMENTAL GENETIC ORIGINS OF CORTICAL INTERNEURONS
Fishell GJ; Sousa V; Batista-Brito R; Miyoshi G; Hjerling-Leffler J
Thesis / dissertation: 2006
Sensory neurons : stem cells and development
Hjerling-Leffler, Jens
Review: PROGRESS IN BRAIN RESEARCH. 2002;138:109-133
Environmental enrichment and the brain
Mohammed AH; Zhu SW; Darmopil S; Hjerling-Leffler J; Ernfors P; Winblad B; Diamond MC; Eriksson PS; Bogdanovic N
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Grants

Brain cell type-specific interactions and schizophrenia
European Research Council
1 April 2019 - 31 March 2024

Employments

Principal Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2023
Doctor Of Philosophy, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2006

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