Janne Lehtiö
Professor/Sjukhuskemist
E-postadress: janne.lehtio@ki.se
Telefon: +46852481416
Besöksadress: SciLifeLab, Tomtebodavägen 23A, 17121 Solna
Postadress: K7 Onkologi-Patologi, K7 Forskning Lehtiö, 171 77 Stockholm
Artiklar
- Article: NATURE COMMUNICATIONS. 2025;16(1):1948Leo IR; Kunold E; Audrey A; Tampere M; Eirich J; Lehtioe J; Jafari R
- Article: ISCIENCE. 2025;28(2):111864Pan Y; Berkovska O; Marathe S; Mermelekas G; Gudoityte G; Wolide AD; Arslan T; Seashore-Ludlow B; Lehtio J; Orre LM
- Article: ALZHEIMERS & DEMENTIA. 2025;21(1):e14375Canal-Garcia A; Branca RM; Francis PT; Ballard C; Winblad B; Lehtio J; Nilsson P; Aarsland D; Pereira JB; Bereczki E
- Article: ONCOIMMUNOLOGY. 2024;13(1):2407532Feodoroff M; Hamdan F; Antignani G; Feola S; Fusciello M; Russo S; Chiaro J; Valimaki K; Pellinen T; Branca RM; Lehtio J; D'alessio F; Bottega P; Stigzelius V; Sandberg J; Clancy J; Partanen J; Malmstedt M; Rannikko A; Pietiaeinen V; Gronholm M; Cerullo V
- Journal article: BLOOD. 2024;144:1565Struyf N; Gezelius H; Lundmark A; Barizza C; Ploeger H; Pizarro LR; Uesterlund M; Mermelekas G; Osterroos A; Bohlin A; Bengtzen S; Levedahl KH; Jafari R; Orre LM; Lehtio J; Ostling P; Seashore-Ludlow B; Nordlund J; Lehmann S; Kallioniemi O; Erkers T
- Article: ADVANCED SCIENCE. 2024;11(41):e2404510Chen Y; Su Y; Cao X; Siavelis I; Leo IR; Zeng J; Tsagkozis P; Hesla AC; Papakonstantinou A; Liu X; Huang W-K; Zhao B; Haglund C; Ehnman M; Johansson H; Lin Y; Lehtioe J; Zhang Y; Larsson O; Li X; de Flon FH
- Article: LEUKEMIA. 2024;38(11):2429-2442Hagerstrand D; Oder B; Cortese D; Qu Y; Binzer-Panchal A; Osterholm C; Santos TDP; Rabbani L; Asl HF; Skaftason A; Ljungstrom V; Lundholm A; Koutroumani M; Haider Z; Jylha C; Mollstedt J; Mansouri L; Plevova K; Agathangelidis A; Scarfo L; Armand M; Muggen AF; Kay NE; Shanafelt T; Rossi D; Orre LM; Pospisilova S; Barylyuk K; Davi F; Vesterlund M; Langerak AW; Lehtio J; Ghia P; Stamatopoulos K; Sutton L-A; Rosenquist R
- Article: CANCER SCIENCE. 2024;115(10):3439-3454Ahamed MT; Forshed J; Levitsky A; Lehtio J; Bajalan A; Pernemalm M; Eriksson LE; Andersson B
- Article: JOURNAL OF PROTEOME RESEARCH. 2024;23(9):4114-4127Sharma N; Angori S; Sandberg A; Mermelekas G; Lehtio J; Wiklander OPB; Gorgens A; El Andaloussi S; Eriksson H; Pernemalm M
- Journal article: CANCERS. 2024;16(16):2888Bartels M; Chibaudel B; Dienstmann R; Lehtiö J; Piccolo A; Michielin O; O'Kane G; Pruneri G
- Article: JOURNAL OF INTERNAL MEDICINE. 2024;295(6):785-803Edsjo A; Russnes HG; Lehtio J; Tamborero D; Hovig E; Stenzinger A; Rosenquist R
- Journal article: ACTA ONCOLOGICA. 2024;63:385-391Taskén K; Haj Mohammad SF; Fagereng GL; Sørum Falk R; Helland Å; Barjesteh van Waalwijk van Doorn-Khosrovani S; Steen Carlsson K; Ryll B; Jalkanen K; Edsjö A; Russnes HG; Lassen U; Hallersjö Hult E; Lugowska I; Blay J-Y; Verlingue L; Abel E; Lowery MA; Krebs MG; Staal Rohrberg K; Ojamaa K; Oliveira J; Verheul HMW; Voest EE; Gelderblom H; PRIME-ROSE Consortium and the PCM4EU Consortium
- Article: BLOOD. 2024;143(19):1953-1964Morsy MHA; Lilienthal I; Lord M; Merrien M; Wasik AM; Sureda-Gomez M; Amador V; Johansson HJ; Lehtio J; Garcia-Torre B; Martin-Subero JI; Tsesmetzis N; Tao S; Schinazi RF; Kim B; Sorteberg AL; Wickstrom M; Sheppard D; Rassidakis GZ; Taylor IA; Christensson B; Campo E; Herold N; Sander B
- Article: NATURE COMMUNICATIONS. 2024;15(1):3837Wang K; Zerdes I; Johansson HJ; Sarhan D; Sun Y; Kanellis DC; Sifakis EG; Mezheyeuski A; Liu X; Loman N; Hedenfalk I; Bergh J; Bartek J; Hatschek T; Lehtio J; Matikas A; Foukakis T
- Journal article: BLOOD CANCER DISCOVERY. 2024;5(2_Supplement):p30Leo IR; Post F; Struyf N; Qi X; Aswad L; Nguyen TT; Tamai M; Akahane K; Pokrovskaja-Tamm K; Erkers T; Inukai T; Lehtiö J; Jafari R
- Article: NPJ PRECISION ONCOLOGY. 2024;8(1):38Struyf N; Osterroos A; Vesterlund M; Arnroth C; James T; Sunandar S; Mermelekas G; Bohlin A; Hamberg Levedahl K; Bengtzen S; Jafari R; Orre LM; Lehtio J; Lehmann S; Ostling P; Kallioniemi O; Seashore-Ludlow B; Erkers T
- Journal article: BLOOD. 2024;143(19):1953-1964Morsy MHA; Lilienthal I; Lord M; Merrien M; Wasik AM; Sureda-Gómez M; Amador V; Johansson HJ; Lehtiö J; Garcia-Torre B; Martin-Subero JI; Tsesmetzis N; Tao S; Schinazi RF; Kim B; Sorteberg AL; Wickström M; Sheppard D; Rassidakis GZ; Taylor IA; Christensson B; Campo E; Herold N; Sander B
- Journal article: LEUKEMIA. 2024;38(11):2429-2442Hagerstrand D; Oder B; Cortese D; Qu Y; Binzer-Panchal A; Osterholm C; Del Peso Santos T; Rabbani L; Asl HF; Skaftason A; Ljungstrom V; Lundholm A; Koutroumani M; Haider Z; Jylha C; Mollstedt J; Mansouri L; Plevova K; Agathangelidis A; Scarfo L; Armand M; Muggen AF; Kay NE; Shanafelt T; Rossi D; Orre LM; Pospisilova S; Barylyuk K; Davi F; Vesterlund M; Langerak AW; Lehtio J; Ghia P; Stamatopoulos K; Sutton L-A; Rosenquist R
- Article: SCIENCE ADVANCES. 2023;9(48):eadg8014Manfredi F; Stasi L; Buonanno S; Marzuttini F; Noviello M; Mastaglio S; Abbati D; Potenza A; Balestrieri C; Cianciotti BC; Tassi E; Feola S; Toffalori C; Punta M; Magnani Z; Camisa B; Tiziano E; Lupo-Stanghellini MT; Branca RM; Lehtioe J; Sikanen TM; Haapala MJ; Cerullo V; Casucci M; Vago L; Ciceri F; Bonini C; Ruggiero E
- Article: NATURE COMMUNICATIONS. 2023;14(1):7056Chiaro J; Antignani G; Feola S; Feodoroff M; Martins B; Cojoc H; Russo S; Fusciello M; Hamdan F; Ferrari V; Ciampi D; Ilonen I; Raesaenen J; Maeyraenpaeae M; Partanen J; Koskela S; Honkanen J; Halonen J; Kuryk L; Rescigno M; Groenholm M; Branca RM; Lehtioe J; Cerullo V
- Article: MOLECULAR CELL. 2023;83(20):3720-3739.e8Brunner A; Li Q; Fisicaro S; Kourtesakis A; Viiliainen J; Johansson HJ; Pandey V; Mayank AK; Lehtio J; Wohlschlegel JA; Spruck C; Rantala JK; Orre LM; Sangfelt O
- Journal article: ANNALS OF ONCOLOGY. 2023;34:s1163-s1164Berkovska O; Mermelekas G; Orre L; Lehtio J
- Article: NATURE COMMUNICATIONS. 2023;14(1):5921Babacic H; Christ W; Araujo JE; Mermelekas G; Sharma N; Tynell J; Garcia M; Varnaite R; Asgeirsson H; Glans H; Lehtioe J; Gredmark-Russ S; Klingstroem J; Pernemalm M
- Journal article: CANCER RESEARCH. 2023;83(7):6612Erkers T; Struyf N; James T; Marabita F; Vesterlund M; Vu N; Arnroth C; Osterroos A; Bohlin A; Bengtzen S; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
- Article: NPJ PRECISION ONCOLOGY. 2023;7(1):32Trac QT; Pawitan Y; Mou T; Erkers T; Ostling P; Bohlin A; Osterroos A; Vesterlund M; Jafari R; Siavelis I; Backvall H; Kiviluoto S; Orre LM; Rantalainen M; Lehtio J; Lehmann S; Kallioniemi O; Vu TN
- Article: LEUKEMIA. 2023;37(3):550-559Stratmann S; Vesterlund M; Umer HM; Eshtad S; Skaftason A; Herlin MK; Sundstrom C; Eriksson A; Hoglund M; Palle J; Abrahamsson J; Jahnukainen K; Munthe-Kaas MC; Zeller B; Tamm KP; Lindskog C; Cavelier L; Lehtio J; Holmfeldt L
- Article: MOLECULAR ONCOLOGY. 2023;17(2):238-260Babacic H; Galardi S; Umer HM; Hellstrom M; Uhrbom L; Maturi N; Cardinali D; Pellegatta S; Michienzi A; Trevisi G; Mangiola A; Lehtio J; Ciafre SA; Pernemalm M
- Article: NATURE COMMUNICATIONS. 2022;13(1):6226Herbst SA; Vesterlund M; Helmboldt AJ; Jafari R; Siavelis I; Stahl M; Schitter EC; Liebers N; Brinkmann BJ; Czernilofsky F; Roider T; Bruch P-M; Iskar M; Kittai A; Huang Y; Lu J; Richter S; Mermelekas G; Umer HM; Knoll M; Kolb C; Lenze A; Cao X; Osterholm C; Wahnschaffe L; Herling C; Scheinost S; Ganzinger M; Mansouri L; Kriegsmann K; Kriegsmann M; Anders S; Zapatka M; Del Poeta G; Zucchetto A; Bomben R; Gattei V; Dreger P; Woyach J; Herling M; Muller-Tidow C; Rosenquist R; Stilgenbauer S; Zenz T; Huber W; Tausch E; Lehtioe J; Dietrich S
- Article: NATURE PROTOCOLS. 2022;17(8):1832-1867Arslan T; Pan Y; Mermelekas G; Vesterlund M; Orre LM; Lehtio J
- Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(6):434-446Silwal-Pandit L; Stalberg SM; Johansson HJ; Mermelekas G; Lothe IMB; Skrede ML; Dalsgaard AM; Nebdal DJH; Helland A; Lingjaerde OC; Labori KJ; Skalhegg BS; Lehtioe J; Kure EH
- Article: NATURE COMMUNICATIONS. 2022;13(1):1691Leo IR; Aswad L; Stahl M; Kunold E; Post F; Erkers T; Struyf N; Mermelekas G; Joshi RN; Gracia-Villacampa E; Ostling P; Kallioniemi OP; Tamm KP; Siavelis I; Lehtio J; Vesterlund M; Jafari R
- Article: ELIFE. 2022;11:e71156A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccinesFeola S; Chiaro J; Martins B; Russo S; Fusciello M; Yloesmaeki E; Bonini C; Ruggiero E; Hamdan F; Feodoroff M; Antignani G; Viitala T; Pesonen S; Groenholm M; Branca RMM; Lehtioe J; Cerullo V; Ho P-C
- Article: BIOINFORMATICS. 2022;38(5):1470-1472Umer HM; Audain E; Zhu Y; Pfeuffer J; Sachsenberg T; Lehtio J; Branca R; Perez-Riverol Y
- Article: NATURE CANCER. 2022;3(2):251-261Tamborero D; Dienstmann R; Rachid MH; Boekel J; Lopez-Fernandez A; Jonsson M; Razzak A; Brana I; De Petris L; Yachnin J; Baird RD; Loriot Y; Massard C; Martin-Romano P; Opdam F; Schlenk RF; Vernieri C; Masucci M; Villalobos X; Chavarria E; Balmana J; Apolone G; Caldas C; Bergh J; Ernberg I; Frohling S; Garralda E; Karlsson C; Tabernero J; Voest E; Rodon J; Lehtio J
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(45):e2100050118Erdelyi K; Ditroi T; Johansson HJ; Czikora A; Balog N; Silwal-Pandit L; Ida T; Olasz J; Hajdu D; Matrai Z; Csuka O; Uchida K; Tovari J; Engebraten O; Akaike T; Dale A-LB; Kasler M; Lehtio J; Nagy P
- Article: NATURE CANCER. 2021;2(11):1224-1242Lehtio J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer HM; Mermelekas G; Pirmoradian M; Jonsson M; Brunnstrom H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevskaz M; Hansen CG; Haakensen VD; Helland A; Tamborero D; Johansson HJ; Branca RM; Planckz M; Staaf J; Orre LM
- Article: ACS NANO. 2021;15(10):15992-16010Feola S; Haapala M; Peltonen K; Capasso C; Martins B; Antignani G; Federico A; Pietiainen V; Chiaro J; Feodoroff M; Russo S; Rannikko A; Fusciello M; Koskela S; Partanen J; Hamdan F; Tahka SM; Ylosmaki E; Greco D; Gronholm M; Kekarainen T; Eshaghi M; Gurvich OL; Yla-Herttuala S; Branca RMM; Lehtio J; Sikanen TM; Cerullo V
- Article: CANCERS. 2021;13(14):3408Peltonen K; Feola S; Umer HM; Chiaro J; Mermelekas G; Ylosmaki E; Pesonen S; Branca RMM; Lehtio J; Cerullo V
- Journal article: CANCER RESEARCH. 2021;81(13_Supplement):1897Feola S; Happala M; Peltonen K; Capasso C; Antignani G; Federico A; Pietiäinen V; Chiaro J; Feodoroff M; Ranniko A; Fusciello M; Koskela S; Partanen J; Hamdan F; Tähkä S; Ylösmäki E; Greco D; Grönholm M; Branca RMM; Lehtiö J; Siikanen T; Cerullo V
- Article: METABOLITES. 2021;11(5):310Jeong H; Yu Y; Johansson HJ; Schroeder FC; Lehtio J; Vacanti NM
- Article: AMERICAN JOURNAL OF HEMATOLOGY. 2021;96(5):580-588Mou T; Pawitan Y; Stahl M; Vesterlund M; Deng W; Jafari R; Bohlin A; Osterroos A; Siavelis L; Backvall H; Erkers T; Kiviluoto S; Seashore-Ludlow B; Ostling P; Orre LM; Kallioniemi O; Lehmann S; Lehtio J; Trung NV
- Article: NATURE REVIEWS METHODS PRIMERS. 2021;1(1):32Christopher JA; Stadler C; Martin CE; Morgenstern M; Pan Y; Betsinger CN; Rattray DG; Mahdessian D; Gingras A-C; Warscheid B; Lehtio J; Cristea IM; Foster LJ; Emili A; Lilley KS
- Article: VIRUSES-BASEL. 2020;12(12):E1423-1423Tampere M; Pettke A; Salata C; Wallner O; Koolmeister T; Cazares-Korner A; Visnes T; Hesselman MC; Kunold E; Wiita E; Kalderen C; Lightowler M; Jemth A-S; Lehtio J; Rosenquist A; Warpman-Berglund U; Helleday T; Mirazimi A; Jafari R; Puumalainen M-R
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(12):2047-2068van Westering TLE; Johansson HJ; Hanson B; Coenen-Stass AML; Lomonosova Y; Tanihata J; Motohashi N; Yokota T; Takeda S; Lehtio J; Wood MJA; EL Andaloussi S; Aoki Y; Roberts TC
- Journal article: BLOOD. 2020;136:10-11Herbst SA; Vesterlund M; Jafari R; Siavelis I; Stahl M; Schitter E; Helmboldt AJ; Iskar M; Liebers N; Czernilofsky F; Roider T; Bruch P-M; Lu J; Richter S; Mermelekas G; Umer HM; Knoll M; Kolb C; Lenze A; Cao X; Osterholm-Corbascio C; Scheinost S; Ganzinger M; Mansouri L; Kriegsmann K; Kriegsmann M; Mueller-Tidow C; Dreger P; Anders S; Zapatka M; Herling M; Rosenquist R; Stilgenbauer S; Zenz T; Huber W; Tausch E; Lehtio J; Dietrich S
- Journal article: PANCREATOLOGY. 2020;20:s129-s130Stålberg S; Silwal-Pandit L; Hamfjord J; Lehtiö J; Kure E
- Article: NEOPLASIA. 2020;22(9):390-398Makela R; Arjonen A; Rahmanto AS; Harma V; Lehtio J; Kuopio T; Helleday T; Sangfelt O; Kononen J; Rantala JK
- Article: BMC GENOMICS. 2020;21(1):590Lytrivi M; Ghaddar K; Lopes M; Rosengren V; Piron A; Yi X; Johansson H; Lehtio J; Igoillo-Esteve M; Cunha DA; Marselli L; Marchetti P; Ortsater H; Eizirik DL; Cnop M
- Article: ELIFE. 2020;9:e57894Brunner A; Rahmanto AS; Johansson H; Franco M; Viiliainen J; Gazi M; Frings O; Fredlund E; Spruck C; Lehtio J; Rantala JK; Larsson L-G; Sangfelt O
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(6):1047-1057Zhu Y; Orre LM; Tran YZ; Mermelekas G; Johansson HJ; Malyutina A; Anders S; Lehtio J
- Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2020;8(1):e000204Babacic H; Lehtio J; de Coana YP; Pernemalm M; Eriksson H
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(4):608-623Herr P; Bostrom J; Rullman E; Rudd SG; Vesterlund M; Lehtio J; Helleday T; Maddalo G; Altun M
- Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
- Article: CIRCULATION RESEARCH. 2020;126(5):571-585Rykaczewska U; Suur BE; Rohl S; Razuvaev A; Lengquist M; Sabater-Lleal M; van der Laan SW; Miller CL; Wirka RC; Kronqvist M; Diez MG; Vesterlund M; Gillgren P; Odeberg J; Lindeman JH; Veglia F; Humphries SE; de Faire U; Baldassarre D; Tremoli E; Lehtio J; Hansson GK; Paulsson-Berne G; Pasterkamp G; Quertermous T; Hamsten A; Eriksson P; Hedin U; Matic L
- Article: FRONTIERS IN ONCOLOGY. 2020;10:51Rad Pour S; Morikawa H; Kiani NA; Gomez-Cabrero D; Hayes A; Zheng X; Pernemalm M; Lehtio J; Mole DJ; Hansson J; Eriksson H; Tegner J
- Article: PLANT PHYSIOLOGY. 2019;181(4):1632-1650Ivanova A; Gill-Hille M; Huang S; Branca RM; Kmiec B; Teixeira PF; Lehtio J; Whelan J; Murcha MW
- Article: AGING CELL. 2019;18(6):e13029Ross JM; Coppotelli G; Branca RM; Kim KM; Lehtio J; Sinclair DA; Olson L
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2708Joshi RN; Stadler C; Lehmann R; Lehtio J; Tegner J; Schmidt A; Vesterlund M
- Article: ISCIENCE. 2019;21:188-204Oliynyk G; Ruiz-Perez MV; Sainero-Alcolado L; Dzieran J; Zirath H; Gallart-Ayala H; Wheelock CE; Johansson HJ; Nilsson R; Lehtio J; Arsenian-Henriksson M
- Article: SCIENTIFIC REPORTS. 2019;9(1):16504Levitsky A; Pernemalm M; Bernhardson B-M; Forshed J; Kolbeck K; Olin M; Henriksson R; Lehtio J; Tishelman C; Eriksson LE
- Journal article: ANNALS OF ONCOLOGY. 2019;30:v536Eriksson H; Babic H; Lehtiö J; Pernemalm M
- Article: FASEB JOURNAL. 2019;33(9):10193-10206Panizza E; Zhang L; Fontana JM; Hamada K; Svensson D; Akkuratov EE; Scott L; Mikoshiba K; Brismar H; Lehtio J; Aperia A
- Article: SCIENTIFIC REPORTS. 2019;9(1):8324Fredolini C; Bystrom S; Sanchez-Rivera L; Ioannou M; Tamburro D; Ponten F; Branca RM; Nilsson P; Lehtio J; Schwenk JM
- Journal article: PANCREATOLOGY. 2019;19:s155Silwal-Pandit L; Johansson H; Stålberg SM; Mermelekas G; Lothe I-MB; Skrede ML; Dalsgaard AM; Helland Å; Skålhegg BS; Labori KJ; Lingjærde OC; Lehtiö J; Kure E
- Article: NATURE COMMUNICATIONS. 2019;10(1):2331Ezzat K; Pernemalm M; Palsson S; Roberts TC; Jarver P; Dondalska A; Bestas B; Sobkowiak MJ; Levanen B; Skold M; Thompson EA; Saher O; Kari OK; Lajunen T; Ekstrom ES; Nilsson C; Ishchenko Y; Malm T; Wood MJA; Power UF; Masich S; Linden A; Sandberg JK; Lehtio J; Spetz A-L; EL Andaloussi S
- Article: CLINICAL CANCER RESEARCH. 2019;25(10):3115-3127Chandran VI; Welinder C; Mansson A-S; Offer S; Freyhult E; Pernemalm M; Lund SM; Pedersen S; Lehtio J; Marko-Varga G; Johansson MC; Englund E; Sundgren PC; Belting M
- Article: NATURE COMMUNICATIONS. 2019;10(1):1600Johansson HJ; Socciarelli F; Vacanti NM; Haugen MH; Zhu Y; Siavelis I; Fernandez-Woodbridge A; Aure MR; Sennblad B; Vesterlund M; Branca RM; Orre LM; Huss M; Fredlund E; Beraki E; Garred O; Boekel J; Sauer T; Zhao W; Nord S; Hoglander EK; Jans DC; Brismar H; Haukaas TH; Bathen TF; Schlichting E; Naume B; Geisler J; Hofvind S; Engebraten O; Geitvik GA; Langerod A; Karesen R; Maelandsmo GM; Sorlie T; Skjerven HK; Park D; Hartman-Johnsen O-J; Luders T; Borgen E; Kristensen VN; Russnes HG; Lingjaerde OC; Mills GB; Sahlberg KK; Borresen-Dale A-L; Lehtio J
- Article: ELIFE. 2019;8:e41608Pernemalm M; Sandberg A; Zhu Y; Boekel J; Tamburro D; Schwenk JM; Bjork A; Wahren-Herlenius M; Amark H; Ostenson C-G; Westgren M; Lehtio J
- Article: NATURE COMMUNICATIONS. 2019;10(1):1519Yang M; Vesterlund M; Siavelis I; Moura-Castro LH; Castor A; Fioretos T; Jafari R; Lilljebjorn H; Odom DT; Olsson L; Ravi N; Woodward EL; Harewood L; Lehtio J; Paulsson K
- Journal article: FASEB JOURNAL. 2019;33:476.21Panizza E; Svensson D; Zhang L; Fontana JM; Akkuratov E; Scott L; Brismar H; Lehtio J; Aperia A
- Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):62Idborg H; Zandian A; Sandberg A-S; Nilsson B; Elvin K; Truedsson L; Sohrabian A; Ronnelid J; Mo J; Grosso G; Kvarnstrom M; Gunnarsson I; Lehtio J; Nilsson P; Svenungsson E; Jakobsson P-J
- Article: MOLECULAR CELL. 2019;73(1):166-182.e7Orre LM; Vesterlund M; Pan Y; Arslan T; Zhu Y; Woodbridge AF; Frings O; Fredlund E; Lehtio J
- Journal article: INNOVATION IN AGING. 2018;2(suppl_1):334Ross JM; Coppotelli G; Branca R; Lehtiö J; Sinclair D; Olson L
- Article: PLANT JOURNAL. 2018;96(4):705-715Kmiec B; Branca RMM; Berkowitz O; Li L; Wang Y; Murcha MW; Whelan J; Lehtioe J; Glaser E; Teixeira PF
- Article: SCIENTIFIC REPORTS. 2018;8(1):15841Jarver P; Dondalska A; Poux C; Sandberg A; Bergenstrahle J; Skold AE; Dereuddre-Bosquet N; Martinon F; Palsson S; Zaghloul E; Brodin D; Sander B; Lennox KA; Behlke MA; EL-Andaloussi S; Lehtio J; Lundeberg J; LeGrand R; Spetz A-L
- Article: CELL DEATH & DISEASE. 2018;9(9):846Dyczynski M; Vesterlund M; Bjorklund A-C; Zachariadis V; Janssen J; Gallart-Ayala H; Daskalaki E; Wheelock CE; Lehtio J; Grander D; Tamm KP; Nilsson R
- Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):464-480Matic LP; Iglesias MJ; Vesterlund M; Lengquist M; Hong M-G; Saieed S; Sanchez-Rivera L; Berg M; Razuvaev A; Kronqvist M; Lund K; Caidahl K; Gillgren P; Ponten F; Uhlen M; Schwenk JM; Hansson GK; Paulsson-Berne G; Fagman E; Roy J; Hultgren R; Bergstrom G; Lehtio J; Odeberg J; Hedin U
- Article: SCIENTIFIC REPORTS. 2018;8(1):10813Sork H; Corso G; Krjutskov K; Johansson HJ; Nordin JZ; Wiklander OPB; Lee YXF; Westholm JO; Lehtio J; Wood MJA; Mager I; El Andaloussi S
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- Corrigendum: SCIENTIFIC REPORTS. 2019;9(1):15014Johansson HJ; Vallhov H; Holm T; Gehrmann U; Andersson A; Johansson C; Blom H; Carroni M; Lehtio J; Scheynius A
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- Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2019;18(8):S40Johansson HJ; Socciarelli F; Vacanti NM; Haugen MH; Zhu Y; Siavelis I; Fernandez-Woodbridge A; Aure MR; Sennblad B; Vesterlund M; Branca RM; Orre LM; Huss M; Fredlund E; Beraki E; Garred O; Boeke J; Sauer T; Zhao W; Nord S; Hoglander EK; Jans DC; Brismar H; Haukaas TH; Bathen TF; Schlichting E; Naume B; Luders T; Borgen E; Kristensen VN; Russnes HG; Lingjaerde OC; Mills GB; Sahlberg KK; Borresen-Dale A-L; Lehtio J
- Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2019;18(8):S30Lehtio J
- Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2019;18(8):S61Umer HM; Zhu Y; Audain E; Lehtio J; Branca R; Perez-Riverol Y
- Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(15):9574Eriksson H; Babacic H; Lehtio J; Pernemalm M
- Conference publication: QUALITY OF LIFE RESEARCH. 2018;27:S2-S3Levitsky A; Pernemalm M; Runesdotter S; Bernhardson B-M; Forshed J; Lehtio J; Tishelman C; Eriksson LE
- Corrigendum: NATURE COMMUNICATIONS. 2018;9(1):1852Zhu Y; Orre LM; Johansson HJ; Huss M; Boekel J; Vesterlund M; Fernandez-Woodbridge A; Branca RMM; Lehtio J
- Preprint: BIORXIV. 2018Ezzat K; Pernemalm M; Pålsson S; Roberts T; Järver P; Dondalska A; Bestas B; Sobkowiak M; Levänen B; Sköld M; Thompson E; Saher O; Kari O; Lajunen T; Ekström ES; Nilsson C; Ishchenko Y; Ishchenko Y; Malm T; Wood MJA; Power U; Masich S; Lindén A; Sandberg J; Lehtiö J; Spetz A-L; Andaloussi SEL
- Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2018;47:2Idborg H; Zandian A; Sandberg A; Truedsson L; Nilsson B; Elvin K; Mo J; Gustafsson J; Gunnarsson I; Lehtio J; Nilsson P; Svenungsson E; Jakobsson P
- Conference publication: PEDIATRIC BLOOD & CANCER. 2017;64:S224-S225Henriksson MA; Oliynyk G; Perez MVR; Dzieran J; Zirath H; Johassson H; Lehtio J
- Preprint: BIORXIV. 2017Wei B; Jolma A; Sahu B; Orre LM; Zhong F; Zhu F; Kivioja T; Sur IK; Lehtiö J; Taipale M; Taipale J
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):290Jarver P; Dondalska A; Skold A; Sandberg A; Zaghloul E; Brodin D; Poux C; Lehtio J; Lennox K; Behlke M; Le Grand R; El-Andaloussi S; Spetz A-L
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):253Vallhov H; Johansson H; Holm T; Gehrmann U; Johansson C; Andersson A; Lehtio J; Scheynius A
- Preprint: BIORXIV. 2017Fredolini C; Byström S; Sanchez-Rivera L; Ioannou M; Tamburro D; Branca R; Nilsson P; Lehtiö J; Schwenk J
- Review: ENVIRONMENTAL MICROBIOLOGY. 2017;19(6):2301-2319Muthusamy S; Lundin D; Branca RMM; Baltar F; Gonzalez JM; Lehtio J; Pinhassi J
- Conference publication: CELL TRANSPLANTATION. 2017;26:704Anderson JD; Rossignol J; Dunbar GL; Yavagal D; EL-Andaloussi S; Lehtio J; Nolta JA
- Conference publication: NEUROMUSCULAR DISORDERS. 2017;27:S5-S6van Westering TLE; Johansson HJ; Coenen-Stass AML; Tanihata J; Takeda S; Yokota T; Lehtio J; Wood MJA; El Andaloussi S; Roberts TC; Aoki Y
- Conference publication: CELL TRANSPLANTATION. 2017;26(4):704Anderson JD; Rossignol J; Dunbar GL; Yavagal D; EL-Andaloussi S; Lehtio J; Nolta JA
- Meeting abstract: CANCER RESEARCH. 2016;76:2385Understanding the dynamic interplay between genetically different cancer cell clones in glioblastomaGuo M; Heller S; Thorslund J; Orre L; Lehtio J; Nister M; Hagerstrand D
- Conference publication: CANCER RESEARCH. 2016;76:3881Johansson H; Zhu Y; Haugland M; Sahlberg K; Fredlund E; Huss M; Vacanti N; Aure MR; Sennblad B; Kjellqvist S; Orre L; Lingjaerde OC; Borresen-Dale A-L; Lehtio J
- Corrigendum: STEM CELLS TRANSLATIONAL MEDICINE. 2016;5(6):845Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalen M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Hagglund H; Mattsson M; Lehtio J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2016;83(5):353Schmidt A; Marabita F; Johansson H; Lehtio J; Eriksson M; Elias S; Gomez-Cabrero D; Rao A; Tegner J
- Preprint: PEERJ PREPRINTS. 2016Muthusamy S; Lundin D; Branca RM; Baltar F; González JM; Lehtiö J; Pinhassi J
- Preprint: PEERJ PREPRINTS. 2016Muthusamy S; Lundin D; Branca RMM; Baltar F; González J; Lehtiö J; Pinhassi J
- Conference publication: CELL TRANSPLANTATION. 2016;25(4):750Proteomic and Therapeutic Profile of Mesenchymal Stem Cell Exosomes in Neurological-Related DiseasesAnderson JD; Rossignol J; Lein P; EL-Andaloussi S; Lehtio J; Nolta JA
- Conference publication: PEDIATRIC BLOOD & CANCER. 2015;62:S179-S180Henriksson MA; Oliynyk G; Zirath H; Johansson H; Lehtio J
- Conference publication: CANCER RESEARCH. 2015;75:3462Fotouhi O; Kjellin H; Hashemi J; Lu M; Juhlin C; Hoog A; Zedenius J; Larsson C; Lehtio J; Kjellman M
- Letter: NATURE BIOTECHNOLOGY. 2015;33(2):137-139Boekel J; Chilton JM; Cooke IR; Horvatovich PL; Jagtap PD; Kall L; Lehtio J; Lukasse P; Moerland PD; Griffin TJ
- Conference publication: 2014;:99-106Kifer I; Ben-Dar A; Yakhini Z; Branca RM; Lehtiö J; Xu P
- Conference publication: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2014;19:S770Griese JJ; Roos K; Cox N; Shafaat HS; Branca RMM; Lehtio J; Graslund A; Lubitz W; Siegbahn PEM; Hogbom M
- Review: EXPERT REVIEW OF PROTEOMICS. 2014;11(4):431-448Pernemalm M; Lehtio J
- Conference publication: ENDOCRINE REVIEWS. 2014;35(3)Lu M; Kjellin H; Fotouhi O; Lee L; Nilsson I-L; Hoog A; Lehtio J; Larsson C
- Conference publication: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2014;19:S278Griese JJ; Graslund A; Hogbom M; Roos K; Siegbahn PE; Cox N; Shafaat HS; Lubitz W; Branca RM; Lehtio J
- Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2014;43:95Jakobsson P-J; Svenungsson E; Idborg H; Nilsson P; Wheelock C; Gunnarsson I; Trygg J; Lehtio J; Koistinen IS
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:466Idborg H; Rannar S; Oliynyk G; Forshed J; Branca RM; Donten M; Bennett K; Gustafsson J; Vikerfors A; Elvin K; Truedsson L; Nilsson B; Gunnarsson I; Trygg J; Lehtio J; Lundstedt T; Svenungsson E; Jakobsson P-J
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2013;71:532Idborg H; Oliynyk G; Rannar S; Forshed J; Branca RM; Donten M; Gustafsson J; Vikerfors A; Gunnarsson I; Trygg J; Lehtio J; Lundstedt T; Svenungsson E; Jakobsson P-J
- Conference publication: CANCER RESEARCH. 2013;73(8):833Orre L; Panizza E; Kaminskyy V; Graslund T; Zhivotovsky B; Lehtio J
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:A80Idborg H; Rannar S; Oliynyk G; Forshed J; Branca RM; Donten M; Bennett K; Gustafsson J; Vikerfors A; Truedsson L; Nilsson B; Gunnarsson I; Trygg J; Lehtio J; Lundstedt T; Svenungsson E; Jakobsson P-J
- Conference publication: ANGIOGENESIS. 2013;16(1):271-272Mae AM; Raschperger E; Keller A; Johansson H; Lavina-Siemsen B; Hofmann J; Olsson C; Lehtio J; Betsholtz C
- Conference publication: ANGIOGENESIS. 2013;16(1):270-271Mae AM; Keller A; Raschperger E; Johansson H; Lavina-Siemsen B; Hofmann J; Lehtio J; Betsholtz C
- Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2012;48:43Azimi A; Johansson CH; Pernemalm M; Touminen R; Lehtio J; Hansson J; Egyhazi S
- Review: FEBS JOURNAL. 2012;279(21):4062-4080Amano M; Eriksson H; Manning JC; Detjen KM; Andre S; Nishimura S-I; Lehtio J; Gabius H-J
- Conference publication: DIABETOLOGIA. 2012;55:S217Rosengren V; Johansson H; Lehtio J; Sjoholm A; Ortsater H
- Conference publication: ANNALS OF ONCOLOGY. 2012;23:33-34Lehtio J; Branca M; Johansson H; Orre M; Granholm V; Forshed J; Perez-Bercoff M; Kall L
- Conference publication: ANNALS OF ONCOLOGY. 2012;23:27Johansson CH; Azimi A; Pernemalm M; Pawitan Y; Stolt MF; Lazar V; Lundeberg J; Lehtio J; Egyhazi S; Hansson J
- Conference publication: ANNALS OF ONCOLOGY. 2012;23:v27Johansson CH; Azimi A; Pernemalm M; Pawitan Y; Stolt MF; Lazar V; Lundeberg J; Lehtiö J; Egyhazi S; Hansson J
- Conference publication: ANNALS OF ONCOLOGY. 2012;23:38Pernemalm A; Branca M; Petris DE; Forshed J; Lewensohn R; Besse B; Lazar V; Van den Oord J; Pawitan Y; Lehtio J
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a12Idborg H; Oliynyk G; Rannar S; Forshed J; Branca RM; Donten M; Gustafsson J; Vikerfors A; Gunnarsson I; Trygg J; Lehtio J; Lundstedt T; Svenungsson E; Jakobsson P-J
- Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2011;47:S124De Petris L; Forshed J; Antti H; Branden E; Koyi H; Johnsson A; Lewensohn R; Lehtio J
- Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2011;47:S78Lehtio J; De Petris L; Pernemalm M; Forshed J; Branca R; Orre LM
- Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2011;6(6):S965-S966De Petris L; Kanter L; Melotti F; Bergman P; Kolbeck K-G; Hellborg H; Adolfsson J; Lewensohn R; Lehtio J
- Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2011;6(6):S1071-S1072Lehtio J; Pernemalm M; Lewensohn R; Van Den Oost J; Forshed J; Branca R; Alexeyenko A; De Petris L; Blackhall F; Pawitan Y; Besse B; Lazar V
- Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2011;6(6):S304Orre LM; Le Sage C; Agami R; Lehtio J
- Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2011;29(15):628Sanchez BC; Johansson H; Forshed J; Stal O; Lehtio J; Linderholm BK
- Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183:a6404Kasuga K; Branca RM; Wahlstrom J; Wheelock AM; Eklund A; Grunewald J; Lehtio J
- Meeting abstract: BREAST. 2011;20:S25Sanchez BC; Johansson H; Lehtio J; Linderholm BK
- Review: JOURNAL OF PROTEOMICS. 2010;73(10):1851-1863Lehtio J; De Petris L
- Conference publication: ANNALS OF ONCOLOGY. 2010;21:41Johansson HJ; Sanchez BC; Bergh J; Linderholm B; Lehtio J
- Conference publication: CANCER RESEARCH. 2010;70:4956Sanchez BC; Johansson H; Lehtio J; Stal O; Linderholm BK
- Conference publication: DIABETOLOGIA. 2009;52:S149Rosengren V; Johansson H; Fransson L; Lehtio J; Sjoholm A; Ortsater H
- Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2009;4(9):S902-S903De Petris L; Branden E; Pernemalm M; Koyi H; Herrmann R; Lewensohn R; Linder S; Lehtio J
- Conference publication: ANNALS OF ONCOLOGY. 2009;20:44Johansson HJ; Sanchez BC; Lehtio J; Linderholm B
- Conference publication: CANCER RESEARCH. 2009;69Sofiadis A; Zedenius J; Wallin G; Foukakis T; Hoog A; Orre L; Lehtio J; Larsson C
- Review: PROTEOMICS. 2009;9(6):1420-1427Pernemalm M; Lewensohn R; Lehtio J
- Conference publication: ANNALS OF ONCOLOGY. 2008;19:50-51Pernemalm M; De Petris L; Branden E; Koyi H; Lewensohn R; Lehtioe J
- Conference publication: ANTICANCER RESEARCH. 2008;28(5C):3497Stahl S; Fung E; Adams C; Lengqvist J; Mork B; Stenerlow B; Lewensohn R; Lehtio J; Zubarev R; Viktorsson K
- Conference publication: ANTICANCER RESEARCH. 2008;28(5C):3275-3276Eriksson H; Lengqvist J; Hedlund J; Uhlen K; Orre LM; Bjellqvist B; Persson B; Lehtio J; Jakobsson P-J
- Conference publication: ANTICANCER RESEARCH. 2008;28(5C):3430-3431Orre LM; Vernet E; Lengvist J; Graslund T; Lewensohn R; Lehtio J
- Review: PROTEOMICS CLINICAL APPLICATIONS. 2007;1(9):1058-1065Hellstrom M; Jonmarker S; Lehtio J; Auer G; Egevad L
- Meeting abstract: JOURNAL OF THORACIC ONCOLOGY. 2007;2(8):S356-S357De Petris L; Pernemalm M; Branden E; Koyi H; Forshed J; Sundelin B; Lewensohn R; Lehtio J
- Published conference paper: PROTEOMICS. 2007;7(11):1746-1752Lengqvist J; Uhlen K; Lehtio J
- Conference publication: BLOOD. 2006;108(11):187BStenke L; Pememalm M; Forshed J; Pawitan Y; Lagergren-Lindberg M; Kanter L; Lehtio J
- Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2006;5(10):S232Stahl S; Viktorsson K; Lennqvist J; Stenerlow B; Lewensohn R; Lehtio J
- Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2006;5(10):S278Pernemalm M; Forshed J; Stenke L; Lewensohn R; Kanter L; Lehtio J
- Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2006;5(10):S190Eriksson H; Lengqvist J; Lehtio J; Kjellman M; Jakobsson P-J
- Conference publication: BLOOD. 2005;106(11):666AStenke L; Orre L; Dhar S; Larsson R; Lewensohn R; Lehtiö J
- Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2005;4(8):S116Lehtio J; Linderholm B; Skoog L; Ploner A; Pawitan Y; Lewensohn R
- Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2005;4(8):S32Tan C; Ploner A; Quandt A; Lehtioe J; Pawitan Y
- Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2005;4(8):S125Pernemalm M; Lehtio J; Lewensohn R; De Petris L; Koy H; Branden E; Brattstrom D
- Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2005;23(16):52SLinderholm BK; Lehtio J; Lidbrink E; Ekman E; Karlsson P; von Wachenfeldt A; Norberg B; Carlsson L; Hatschek T; Lewensohn R
- Published conference paper: LECTURE NOTES IN COMPUTER SCIENCE. 2005;3695:140-150Quandt A; Ploner A; Tan CS; Lehtiö J; Pawitan Y
- Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2004;3(10):S35Orre L; Dhar S; Lewensohn R; Stenke L; Larsson R; Lehtioe J
- Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2004;22(14):863SLinderholm BK; Lehtio J; Ploner A; Pawitan Y; Skoog L; Lewensohn R
- Review: JOURNAL OF BIOTECHNOLOGY. 2002;96(1):67-78Wernérus H; Lehtiö J; Samuelson P; Ståhl S
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Forskningsbidrag
- Swedish Cancer Society1 January 2024Every malignant tumor that is detected has managed to evade the body's immune system. The immune system is responsible for detecting and eliminating cancer cells. It is done via foreign proteins, called cancer antigens, which are created by the cancer cell's altered DNA. We know very little about the types of cancer antigens that can be recognized by our immune system and new research suggests that there are significantly more antigen types than we know today, e.g. ones made from old viral genes in the genome. To understand this better, we need to study the proteins expressed by cancer cells that represent their "molecular fingerprint". There are large knowledge gaps regarding protein level regulation in cancer immunology. We have developed a new method for detecting cancer antigens, where proteins from cancer cells are identified and compared with the patient's DNA. It gives us a more comprehensive picture of the cancer antigens recognized by our immune system. The aim is to use this knowledge to understand how cancer cells evade the immune system, and to develop biomarkers that can predict how cancer cells make themselves invisible. We will start by studying patient samples, then use model systems to test our findings, and finally validate results again on patient samples. Our goal is that this research should lead to new knowledge about the mechanisms by which cancer cells hide from the immune system. This new knowledge should enable new ways to treat cancer by helping our immune system to recognize cancer cells with precision, for example via the development of cancer vaccines, and find better biomarkers to choose effective treatment combinations.
- Swedish Research Council1 January 2023 - 31 December 2026The rapid development of technologies for molecular profiling paves the way for precision medicine approaches to match patients with effective treatment. Through the development of a coordinating support unit, we aim to provide access to SciLifeLab’s technology platforms to support academic and industry-initiated clinical trials. We will establish customized diagnostic packages jointly with clinical trials units across the country to strengthen our attractiveness as a clinical trial site and to ensure early access of patients to both innovative technologies and emerging treatments.Our goal is to identify mature technologies to be evaluated in observational studies and adopted in interventional biomarker-driven clinical trials. To build this capacity, connecting SciLifeLab national infrastructure to clinical practice, key developments supporting cross-platform data, sample and analysis flows with timelines and quality complying with the needs of clinical trials are needed. Our unit will unite services from current and emerging sequencing technologies, to proteome, metabolome, spatial biology techniques, and drug efficacy testing. Our competitive edge is the repertoire of technologies at SciLifeLab, which once combined provide a unique opportunity for clinical trials. With the ‘service packages’ we aim to make Sweden competitive as a trial site, catalyze academy-industry ecosystems and provide opportunities for early access to the latest diagnostic technologies and treatments.
- Swedish Research Council1 January 2023 - 31 December 2025This nursing science precision health project, focus on complex interactions among biological, social, and behavioural factors, and their effects on outcomes. By researching patients’ experience of symptoms and linking these to biological data, we aim to increase the sensitivity and specificity of LC diagnosis and to aid in investigate molecular determinants of common symptoms, e.g. fatigue and cachexia. Furthermore, we aim to develop our measures for use to monitor treatment response in patients receiving immunotherapy. With previous VR funding (2016-1712, 2019-1222), we developed an interactive questionnaire, Peklung, to generate detailed descriptions about early health changes in LC and used it to collect data from ∼700 patients at diagnostic LC work-upin parallel we also collected plasma samples from these patients. We apply here for continued VR funding to link patient-reported data from Peklung with biomolecular and imaging profiles, to determine biomarkers of LC and other lung diseases, and to investigate new molecular determinants of symptoms with unclear aetiology and mechanism, e.g. fatigue, cachexia. Establishing symptomatology related to early LC can: decrease diagnostic delay, with increased chance of curative treatment options and shorter time spans to curative or palliative treatment, thus reducing distress for patients/familiesconnect detailed symptom with omics data to increase understanding of mechanisms of poorly understood symptoms.
- Swedish Research Council1 January 2022 - 31 December 2024
- Facilitating Early Diagnosis of Lung Cancer: Transdisciplinary Efforts Combining Data from Patient-Reports, Biomarkers and ImagingSjöbergstiftelsen1 January 2022 - 31 December 2024
- Barncancerfonden1 January 2022 - 31 December 2022
- Swedish Cancer Society1 January 2021Genomics has contributed greatly to tailored treatment of cancer patients, but the impact on overall cancer survival has been lower than expected. Predicting drug response based on genetic profile alone has proven difficult and even more difficult when aiming to understand synergistic effects of multiple genetic changes. Molecular information on other levels about cell function is required to gain more knowledge about which drug(s) the patient will respond best to. Proteomics, where all the proteins of the cell are studied, offers unique and important information about the actual functional level of the cancer cell. We have developed a proteogenomics method that has been used for the analysis of lung cancer, AML and CLL to gain knowledge of how genetic changes affect the proteome. We have found distinct groups/clusters of tumors that are related to clinical outcome, highlighting the importance of including proteome data for treatment selection. We aim to build on this analysis with large clinical cohorts with proteogenomics and try to connect discovered phenotype clusters to different cancer drugs including immunotherapy drugs. Within the project, panels of biomarkers will be used as a starting point for proteogenomics-based clinical trials. The purpose of the project is to create better conditions for the individualization of cancer treatment by combining genome and proteome analysis. With this, the right cancer treatment can be given to the right patient for the best effect and with the least possible side effects. Furthermore, we generate unique proteomics data that will contribute with new fundamental knowledge about how genome deviation can synergistically affect the growth ability of tumor cells and thus contribute with important pieces of the puzzle for the development of new treatments. This project will also form a workflow towards clinical implementation of proteogenomics in Sweden.
- VINNOVA6 May 2020 - 31 January 2021
- Swedish Research Council1 January 2020 - 31 December 2022
- Swedish Research Council1 January 2020 - 31 December 2023
- Proteogenomics for next generation cancer immunotherapySwedish Cancer Society1 January 2018Proteogenomics is a new field of research in which mass spectrometry-based proteomics data, DNA and RNA data are combined for new knowledge of how changes in effect affect the proteome. These methods allow for the study of protein variants and tumor-specific proteins. Cancer is caused by an accumulation of alterations that give rise to foreign proteins found in tumors. These foreign proteins can activate the immune response and with immunotherapy, the immune system can be strengthened to attack cancer cells. For effective immunotherapy, tumor-specific proteins need to be identified. One limitation with today's methods of identifying tumor-specific proteins is that it is based only on data from the DNA and RNA level and not on the presence of the protein itself. This leads to the loss of information about certain types of tumor-specific proteins and it is difficult to know which modifications ultimately produce proteins. We have developed a proteogenomic method, where we have shown that we can identify and quantify these tumor-specific proteins. The method generates a more complete and specific identification of these proteins, which increases the potential for improved and more effective immunotherapy to combat cancer. The project will primarily focus on the identification and quantification of tumor-specific proteins at protein level in three different tumor formsmalignant melanoma, lung cancer and leukemia. We intend to optimize the workflow for MS-based proteogenomics in order to obtain a robust method flow to identify tumor-specific proteins at the protein level. We intend to evaluate these mutated proteins as possible predictive markers for treatment with immunotherapy drugs. We also expect to gain valuable knowledge of tumor-specific protease at protein level, which was previously lacking, which can improve and enhance today's cancer immunotherapy.
- Proteogenomics for next generation cancer immunotherapySwedish Cancer Society1 January 2017Proteogenomics is a new field of research in which mass spectrometry-based proteomics data, DNA and RNA data are combined for new knowledge of how changes in effect affect the proteome. These methods allow for the study of protein variants and tumor-specific proteins. Cancer is caused by an accumulation of alterations that give rise to foreign proteins found in tumors. These foreign proteins can activate the immune response and with immunotherapy, the immune system can be strengthened to attack cancer cells. For effective immunotherapy, tumor-specific proteins need to be identified. One limitation with today's methods of identifying tumor-specific proteins is that it is based only on data from the DNA and RNA level and not on the presence of the protein itself. This leads to the loss of information about certain types of tumor-specific proteins and it is difficult to know which modifications ultimately produce proteins. We have developed a proteogenomic method, where we have shown that we can identify and quantify these tumor-specific proteins. The method generates a more complete and specific identification of these proteins, which increases the potential for improved and more effective immunotherapy to combat cancer. The project will primarily focus on the identification and quantification of tumor-specific proteins at protein level in three different tumor formsmalignant melanoma, lung cancer and leukemia. We intend to optimize the workflow for MS-based proteogenomics in order to obtain a robust method flow to identify tumor-specific proteins at the protein level. We intend to evaluate these mutated proteins as possible predictive markers for treatment with immunotherapy drugs. We also expect to gain valuable knowledge of tumor-specific protease at protein level, which was previously lacking, which can improve and enhance today's cancer immunotherapy.
- Swedish Research Council1 January 2017 - 31 December 2019
- Proteogenomics - Improved understanding of cancer mutations by linking gene and protein level assaysSwedish Cancer Society1 January 2016Cancer is a disease caused by gene mutations and chromosomal changes. The development in DNA and RNA sequencing has led to an explosion of available data on these changes. Despite this enormous increase in knowledge, the knowledge of the influence of changes on the function of the cell is lacking. A new field called proteogenomics is a strategy that integrates data from genomic and proteomic studies. We have further developed a method in proteogenomics, which makes it possible to describe protein coding genes with protein level analysis, and can be used both for interpretation of gene sequence data and for finding new disease-related genes. With our method, we have discovered almost 100 new human protein coding genes, several of which were pseudogens. Initially, we will study these pseudogenic proteins and their role in cancer. We will also analyze the protein variants that arise from one and the same gene, with particular focus on how different protein variants are formed and how this affects the properties of the tumor. Finally, we will combine data on DNA, RNA and protein levels from analyzes of lung and breast cancer, where we will study in detail how different genetic changes affect the signaling pathways that drive tumor growth and survival. In this project we will generate new information and knowledge about how gene and chromosomal changes affect the functional level in tumor biology. The project will add a new knowledge base at protein level, especially about pseudogenic proteins and the function of protein variants, which is relevant for cancer and its development. With this new information we intend to discover new biomarkers and new "targets" for cancer therapy, with a focus on lung cancer, breast cancer and endocrine tumors. It can create new treatment options for patients, especially for those patients who today show resistance to today's standardized therapy.
- Swedish Research Council1 January 2016 - 31 December 2019
- Infrastructure for information-rich proteome analysisSwedish Foundation for Strategic Research1 January 2016 - 31 December 2020
- Proteogenomics - Improved understanding of cancer mutations by linking gene and protein level assaysSwedish Cancer Society1 January 2015Cancer is a disease caused by gene mutations and chromosomal changes. The development in DNA and RNA sequencing has led to an explosion of available data on these changes. Despite this enormous increase in knowledge, the knowledge of the influence of changes on the function of the cell is lacking. A new field called proteogenomics is a strategy that integrates data from genomic and proteomic studies. We have further developed a method in proteogenomics, which makes it possible to describe protein coding genes with protein level analysis, and can be used both for interpretation of gene sequence data and for finding new disease-related genes. With our method, we have discovered almost 100 new human protein coding genes, several of which were pseudogens. Initially, we will study these pseudogenic proteins and their role in cancer. We will also analyze the protein variants that arise from one and the same gene, with particular focus on how different protein variants are formed and how this affects the properties of the tumor. Finally, we will combine data on DNA, RNA and protein levels from analyzes of lung and breast cancer, where we will study in detail how different genetic changes affect the signaling pathways that drive tumor growth and survival. In this project we will generate new information and knowledge about how gene and chromosomal changes affect the functional level in tumor biology. The project will add a new knowledge base at protein level, especially about pseudogenic proteins and the function of protein variants, which is relevant for cancer and its development. With this new information we intend to discover new biomarkers and new "targets" for cancer therapy, with a focus on lung cancer, breast cancer and endocrine tumors. It can create new treatment options for patients, especially for those patients who today show resistance to today's standardized therapy.
- Proteogenomics - Improved understanding of cancer mutations by linking gene and protein level assaysSwedish Cancer Society1 January 2014Cancer is a disease caused by gene mutations and chromosomal changes. The development in DNA and RNA sequencing has led to an explosion of available data on these changes. Despite this enormous increase in knowledge, the knowledge of the influence of changes on the function of the cell is lacking. A new field called proteogenomics is a strategy that integrates data from genomic and proteomic studies. We have further developed a method in proteogenomics, which makes it possible to describe protein coding genes with protein level analysis, and can be used both for interpretation of gene sequence data and for finding new disease-related genes. With our method, we have discovered almost 100 new human protein coding genes, several of which were pseudogens. Initially, we will study these pseudogenic proteins and their role in cancer. We will also analyze the protein variants that arise from one and the same gene, with particular focus on how different protein variants are formed and how this affects the properties of the tumor. Finally, we will combine data on DNA, RNA and protein levels from analyzes of lung and breast cancer, where we will study in detail how different genetic changes affect the signaling pathways that drive tumor growth and survival. In this project we will generate new information and knowledge about how gene and chromosomal changes affect the functional level in tumor biology. The project will add a new knowledge base at protein level, especially about pseudogenic proteins and the function of protein variants, which is relevant for cancer and its development. With this new information we intend to discover new biomarkers and new "targets" for cancer therapy, with a focus on lung cancer, breast cancer and endocrine tumors. It can create new treatment options for patients, especially for those patients who today show resistance to today's standardized therapy.
- Swedish Research Council1 January 2014 - 31 December 2017
- Application from Johnathon D. Anderson in the Graduate Research Opportunity Worldwide programSwedish Research Council1 January 2013 - 31 December 2013
- High Resolution peptide IsoElectric Focusing (HiRIEF), a method for in-depth quantitative proteomicsSwedish Research Council1 January 2013 - 31 December 2015
- Swedish Research Council1 January 2010 - 31 December 2012
- Swedish Research Council1 January 2010 - 31 December 2012
- Swedish Research Council1 January 2009 - 31 December 2011
- Swedish Research Council1 January 2009 - 31 October 2014
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Anställningar
- Professor/Sjukhuskemist, Onkologi-Patologi, Karolinska Institutet, 2021-
Examina och utbildning
- Docent, Proteomik, Karolinska Institutet, 2009