Janne Lehtiö

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: NATURE COMMUNICATIONS. 2025;16(1):1948
Functional proteoform group deconvolution reveals a broader spectrum of ibrutinib off-targets
Leo IR; Kunold E; Audrey A; Tampere M; Eirich J; Lehtioe J; Jafari R
Article: ISCIENCE. 2025;28(2):111864
Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer
Pan Y; Berkovska O; Marathe S; Mermelekas G; Gudoityte G; Wolide AD; Arslan T; Seashore-Ludlow B; Lehtio J; Orre LM
Article: ALZHEIMERS & DEMENTIA. 2025;21(1):e14375
Proteomic signatures of Alzheimer's disease and Lewy body dementias: A comparative analysis
Canal-Garcia A; Branca RM; Francis PT; Ballard C; Winblad B; Lehtio J; Nilsson P; Aarsland D; Pereira JB; Bereczki E
Article: ONCOIMMUNOLOGY. 2024;13(1):2407532
Enhancing T-cell recruitment in renal cell carcinoma with cytokine-armed adenoviruses
Feodoroff M; Hamdan F; Antignani G; Feola S; Fusciello M; Russo S; Chiaro J; Valimaki K; Pellinen T; Branca RM; Lehtio J; D'alessio F; Bottega P; Stigzelius V; Sandberg J; Clancy J; Partanen J; Malmstedt M; Rannikko A; Pietiaeinen V; Gronholm M; Cerullo V
Journal article: BLOOD. 2024;144(Supplement 1):1565
Resistance to FLT3 Inhibitors in FLT3-Mutated AML Is Associated with CD45RA+CD200- leukemic Cells and Can be Overcome By Combination with SMAC Mimetics
Struyf N; Gezelius H; Lundmark A; Barizza C; Ploeger H; Pizarro LR; Vesterlund M; Mermelekas G; Osterroos A; Bohlin A; Bengtzén S; Levedahl KH; Jafari R; Orre LM; Lehtiö J; Östling P; Seashore-Ludlow B; Nordlund J; Lehmann S; Kallioniemi O; Erkers T
Article: ADVANCED SCIENCE. 2024;11(41):e2404510
Molecular Profiling Defines Three Subtypes of Synovial Sarcoma
Chen Y; Su Y; Cao X; Siavelis I; Leo IR; Zeng J; Tsagkozis P; Hesla AC; Papakonstantinou A; Liu X; Huang W-K; Zhao B; Haglund C; Ehnman M; Johansson H; Lin Y; Lehtioe J; Zhang Y; Larsson O; Li X; de Flon FH
Article: LEUKEMIA. 2024;38(11):2429-2442
The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia
Hagerstrand D; Oder B; Cortese D; Qu Y; Binzer-Panchal A; Osterholm C; Santos TDP; Rabbani L; Asl HF; Skaftason A; Ljungstrom V; Lundholm A; Koutroumani M; Haider Z; Jylha C; Mollstedt J; Mansouri L; Plevova K; Agathangelidis A; Scarfo L; Armand M; Muggen AF; Kay NE; Shanafelt T; Rossi D; Orre LM; Pospisilova S; Barylyuk K; Davi F; Vesterlund M; Langerak AW; Lehtio J; Ghia P; Stamatopoulos K; Sutton L-A; Rosenquist R
Article: CANCER SCIENCE. 2024;115(10):3439-3454
Multiplex plasma protein assays as a diagnostic tool for lung cancer
Ahamed MT; Forshed J; Levitsky A; Lehtio J; Bajalan A; Pernemalm M; Eriksson LE; Andersson B
Article: JOURNAL OF PROTEOME RESEARCH. 2024;23(9):4114-4127
Defining the Soluble and Extracellular Vesicle Protein Compartments of Plasma Using In-Depth Mass Spectrometry-Based Proteomics
Sharma N; Angori S; Sandberg A; Mermelekas G; Lehtio J; Wiklander OPB; Gorgens A; El Andaloussi S; Eriksson H; Pernemalm M
Journal article: CANCERS. 2024;16(16):2888
Evolving and Improving the Sustainability of Molecular Tumor Boards: The Value and Challenges.
Bartels M; Chibaudel B; Dienstmann R; Lehtiö J; Piccolo A; Michielin O; O'Kane G; Pruneri G
Article: JOURNAL OF INTERNAL MEDICINE. 2024;295(6):785-803
High-throughput molecular assays for inclusion in personalised oncology trials - State-of-the-art and beyond
Edsjo A; Russnes HG; Lehtio J; Tamborero D; Hovig E; Stenzinger A; Rosenquist R
Journal article: ACTA ONCOLOGICA. 2024;63:385-391
PCM4EU and PRIME-ROSE: Collaboration for implementation of precision cancer medicine in Europe.
Taskén K; F Haj Mohammad S; Fagereng GL; Sørum Falk R; Helland Å; Barjesteh van Waalwijk van Doorn-Khosrovani S; Steen Carlsson K; Ryll B; Jalkanen K; Edsjö A; Russnes HG; Lassen U; Hallersjö Hult E; Lugowska I; Blay J-Y; Verlingue L; Abel E; Lowery MA; Krebs MG; Staal Rohrberg K; Ojamaa K; Oliveira J; Verheul HMW; Voest EE; Gelderblom H; PRIME-ROSE Consortium and the PCM4EU Consortium
Article: BLOOD. 2024;143(19):1953-1964
SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma
Morsy MHA; Lilienthal I; Lord M; Merrien M; Wasik AM; Sureda-Gomez M; Amador V; Johansson HJ; Lehtio J; Garcia-Torre B; Martin-Subero JI; Tsesmetzis N; Tao S; Schinazi RF; Kim B; Sorteberg AL; Wickstrom M; Sheppard D; Rassidakis GZ; Taylor IA; Christensson B; Campo E; Herold N; Sander B
Article: NATURE COMMUNICATIONS. 2024;15(1):3837
Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer
Wang K; Zerdes I; Johansson HJ; Sarhan D; Sun Y; Kanellis DC; Sifakis EG; Mezheyeuski A; Liu X; Loman N; Hedenfalk I; Bergh J; Bartek J; Hatschek T; Lehtio J; Matikas A; Foukakis T
Journal article: BLOOD CANCER DISCOVERY. 2024;5(2_Supplement):p30
Abstract P30: Therapeutic activation of pre-B-cell receptor signaling in high-risk pediatric ALL: exploiting TCF3 and MYC-linked vulnerabilities
Leo IR; Post F; Struyf N; Qi X; Aswad L; Nguyen TT; Tamai M; Akahane K; Pokrovskaja-Tamm K; Erkers T; Inukai T; Lehtiö J; Jafari R
Article: NPJ PRECISION ONCOLOGY. 2024;8(1):38
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Struyf N; Osterroos A; Vesterlund M; Arnroth C; James T; Sunandar S; Mermelekas G; Bohlin A; Hamberg Levedahl K; Bengtzen S; Jafari R; Orre LM; Lehtio J; Lehmann S; Ostling P; Kallioniemi O; Seashore-Ludlow B; Erkers T
Journal article: BLOOD. 2024;143(19):1953-1964
SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
Morsy MHA; Lilienthal I; Lord M; Merrien M; Wasik AM; Sureda-Gómez M; Amador V; Johansson HJ; Lehtiö J; Garcia-Torre B; Martin-Subero JI; Tsesmetzis N; Tao S; Schinazi RF; Kim B; Sorteberg AL; Wickström M; Sheppard D; Rassidakis GZ; Taylor IA; Christensson B; Campo E; Herold N; Sander B
Journal article: LEUKEMIA. 2024;38(11):2429-2442
The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia
Hagerstrand D; Oder B; Cortese D; Qu Y; Binzer-Panchal A; Osterholm C; Del Peso Santos T; Rabbani L; Asl HF; Skaftason A; Ljungstrom V; Lundholm A; Koutroumani M; Haider Z; Jylha C; Mollstedt J; Mansouri L; Plevova K; Agathangelidis A; Scarfo L; Armand M; Muggen AF; Kay NE; Shanafelt T; Rossi D; Orre LM; Pospisilova S; Barylyuk K; Davi F; Vesterlund M; Langerak AW; Lehtio J; Ghia P; Stamatopoulos K; Sutton L-A; Rosenquist R
Article: SCIENCE ADVANCES. 2023;9(48):eadg8014
Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR
Manfredi F; Stasi L; Buonanno S; Marzuttini F; Noviello M; Mastaglio S; Abbati D; Potenza A; Balestrieri C; Cianciotti BC; Tassi E; Feola S; Toffalori C; Punta M; Magnani Z; Camisa B; Tiziano E; Lupo-Stanghellini MT; Branca RM; Lehtioe J; Sikanen TM; Haapala MJ; Cerullo V; Casucci M; Vago L; Ciceri F; Bonini C; Ruggiero E
Article: NATURE COMMUNICATIONS. 2023;14(1):7056
Development of mesothelioma-specific oncolytic immunotherapy enabled by immunopeptidomics of murine and human mesothelioma tumors
Chiaro J; Antignani G; Feola S; Feodoroff M; Martins B; Cojoc H; Russo S; Fusciello M; Hamdan F; Ferrari V; Ciampi D; Ilonen I; Raesaenen J; Maeyraenpaeae M; Partanen J; Koskela S; Honkanen J; Halonen J; Kuryk L; Rescigno M; Groenholm M; Branca RM; Lehtioe J; Cerullo V
Article: MOLECULAR CELL. 2023;83(20):3720-3739.e8
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress
Brunner A; Li Q; Fisicaro S; Kourtesakis A; Viiliainen J; Johansson HJ; Pandey V; Mayank AK; Lehtio J; Wohlschlegel JA; Spruck C; Rantala JK; Orre LM; Sangfelt O
Journal article: ANNALS OF ONCOLOGY. 2023;34:s1163-s1164
Proteomics-based phenotypic classification of non-smallcell lung cancer
Berkovska O; Mermelekas G; Orre L; Lehtio J
Article: NATURE COMMUNICATIONS. 2023;14(1):5921
Comprehensive proteomics and meta-analysis of COVID-19 host response
Babacic H; Christ W; Araujo JE; Mermelekas G; Sharma N; Tynell J; Garcia M; Varnaite R; Asgeirsson H; Glans H; Lehtioe J; Gredmark-Russ S; Klingstroem J; Pernemalm M
Journal article: CANCER RESEARCH. 2023;83(7):6612
Data-driven hallmarks of cancer as a new paradigm for precision medicine: multi-omics and functional profiling in acute myeloid leukemia
Erkers T; Struyf N; James T; Marabita F; Vesterlund M; Vu N; Arnroth C; Osterroos A; Bohlin A; Bengtzen S; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
Article: NPJ PRECISION ONCOLOGY. 2023;7(1):32
Prediction model for drug response of acute myeloid leukemia patients
Trac QT; Pawitan Y; Mou T; Erkers T; Ostling P; Bohlin A; Osterroos A; Vesterlund M; Jafari R; Siavelis I; Backvall H; Kiviluoto S; Orre LM; Rantalainen M; Lehtio J; Lehmann S; Kallioniemi O; Vu TN
Article: LEUKEMIA. 2023;37(3):550-559
Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children
Stratmann S; Vesterlund M; Umer HM; Eshtad S; Skaftason A; Herlin MK; Sundstrom C; Eriksson A; Hoglund M; Palle J; Abrahamsson J; Jahnukainen K; Munthe-Kaas MC; Zeller B; Tamm KP; Lindskog C; Cavelier L; Lehtio J; Holmfeldt L
Article: MOLECULAR ONCOLOGY. 2023;17(2):238-260
Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures
Babacic H; Galardi S; Umer HM; Hellstrom M; Uhrbom L; Maturi N; Cardinali D; Pellegatta S; Michienzi A; Trevisi G; Mangiola A; Lehtio J; Ciafre SA; Pernemalm M
Article: NATURE COMMUNICATIONS. 2022;13(1):6226
Proteogenomics refines the molecular classification of chronic lymphocytic leukemia
Herbst SA; Vesterlund M; Helmboldt AJ; Jafari R; Siavelis I; Stahl M; Schitter EC; Liebers N; Brinkmann BJ; Czernilofsky F; Roider T; Bruch P-M; Iskar M; Kittai A; Huang Y; Lu J; Richter S; Mermelekas G; Umer HM; Knoll M; Kolb C; Lenze A; Cao X; Osterholm C; Wahnschaffe L; Herling C; Scheinost S; Ganzinger M; Mansouri L; Kriegsmann K; Kriegsmann M; Anders S; Zapatka M; Del Poeta G; Zucchetto A; Bomben R; Gattei V; Dreger P; Woyach J; Herling M; Muller-Tidow C; Rosenquist R; Stilgenbauer S; Zenz T; Huber W; Tausch E; Lehtioe J; Dietrich S
Article: NATURE PROTOCOLS. 2022;17(8):1832-1867
SubCellBarCode: integrated workflow for robust spatial proteomics by mass spectrometry
Arslan T; Pan Y; Mermelekas G; Vesterlund M; Orre LM; Lehtio J
Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(6):434-446
Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome
Silwal-Pandit L; Stalberg SM; Johansson HJ; Mermelekas G; Lothe IMB; Skrede ML; Dalsgaard AM; Nebdal DJH; Helland A; Lingjaerde OC; Labori KJ; Skalhegg BS; Lehtioe J; Kure EH
Article: NATURE COMMUNICATIONS. 2022;13(1):1691
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines
Leo IR; Aswad L; Stahl M; Kunold E; Post F; Erkers T; Struyf N; Mermelekas G; Joshi RN; Gracia-Villacampa E; Ostling P; Kallioniemi OP; Tamm KP; Siavelis I; Lehtio J; Vesterlund M; Jafari R
Article: ELIFE. 2022;11:e71156
A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines
Feola S; Chiaro J; Martins B; Russo S; Fusciello M; Yloesmaeki E; Bonini C; Ruggiero E; Hamdan F; Feodoroff M; Antignani G; Viitala T; Pesonen S; Groenholm M; Branca RMM; Lehtioe J; Cerullo V; Ho P-C
Article: BIOINFORMATICS. 2022;38(5):1470-1472
Generation of ENSEMBL-based proteogenomics databases boosts the identification of non-canonical peptides
Umer HM; Audain E; Zhu Y; Pfeuffer J; Sachsenberg T; Lehtio J; Branca R; Perez-Riverol Y
Article: NATURE CANCER. 2022;3(2):251-261
The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology
Tamborero D; Dienstmann R; Rachid MH; Boekel J; Lopez-Fernandez A; Jonsson M; Razzak A; Brana I; De Petris L; Yachnin J; Baird RD; Loriot Y; Massard C; Martin-Romano P; Opdam F; Schlenk RF; Vernieri C; Masucci M; Villalobos X; Chavarria E; Balmana J; Apolone G; Caldas C; Bergh J; Ernberg I; Frohling S; Garralda E; Karlsson C; Tabernero J; Voest E; Rodon J; Lehtio J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(45):e2100050118
Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation
Erdelyi K; Ditroi T; Johansson HJ; Czikora A; Balog N; Silwal-Pandit L; Ida T; Olasz J; Hajdu D; Matrai Z; Csuka O; Uchida K; Tovari J; Engebraten O; Akaike T; Dale A-LB; Kasler M; Lehtio J; Nagy P
Article: NATURE CANCER. 2021;2(11):1224-1242
Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms
Lehtio J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer HM; Mermelekas G; Pirmoradian M; Jonsson M; Brunnstrom H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevskaz M; Hansen CG; Haakensen VD; Helland A; Tamborero D; Johansson HJ; Branca RM; Planckz M; Staaf J; Orre LM
Article: ACS NANO. 2021;15(10):15992-16010
PeptiCHIP: A Microfluidic Platform for Tumor Antigen Landscape Identification
Feola S; Haapala M; Peltonen K; Capasso C; Martins B; Antignani G; Federico A; Pietiainen V; Chiaro J; Feodoroff M; Russo S; Rannikko A; Fusciello M; Koskela S; Partanen J; Hamdan F; Tahka SM; Ylosmaki E; Greco D; Gronholm M; Kekarainen T; Eshaghi M; Gurvich OL; Yla-Herttuala S; Branca RMM; Lehtio J; Sikanen TM; Cerullo V
Article: CANCERS. 2021;13(14):3408
Therapeutic Cancer Vaccination with Immunopeptidomics-Discovered Antigens Confers Protective Antitumor Efficacy
Peltonen K; Feola S; Umer HM; Chiaro J; Mermelekas G; Ylosmaki E; Pesonen S; Branca RMM; Lehtio J; Cerullo V
Journal article: CANCER RESEARCH. 2021;81(13_Supplement):1897
Abstract 1897: PeptiCHIP: A novel microfluidic-based chip platform for tumor antigen landscape identification
Feola S; Happala M; Peltonen K; Capasso C; Antignani G; Federico A; Pietiäinen V; Chiaro J; Feodoroff M; Ranniko A; Fusciello M; Koskela S; Partanen J; Hamdan F; Tähkä S; Ylösmäki E; Greco D; Grönholm M; Branca RMM; Lehtiö J; Siikanen T; Cerullo V
Article: METABOLITES. 2021;11(5):310
Correcting for Naturally Occurring Mass Isotopologue Abundances in Stable-Isotope Tracing Experiments with PolyMID
Jeong H; Yu Y; Johansson HJ; Schroeder FC; Lehtio J; Vacanti NM
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2021;96(5):580-588
The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia
Mou T; Pawitan Y; Stahl M; Vesterlund M; Deng W; Jafari R; Bohlin A; Osterroos A; Siavelis L; Backvall H; Erkers T; Kiviluoto S; Seashore-Ludlow B; Ostling P; Orre LM; Kallioniemi O; Lehmann S; Lehtio J; Trung NV
Article: NATURE REVIEWS METHODS PRIMERS. 2021;1(1):32
Subcellular proteomics
Christopher JA; Stadler C; Martin CE; Morgenstern M; Pan Y; Betsinger CN; Rattray DG; Mahdessian D; Gingras A-C; Warscheid B; Lehtio J; Cristea IM; Foster LJ; Emili A; Lilley KS
Article: VIRUSES-BASEL. 2020;12(12):E1423-1423
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses
Tampere M; Pettke A; Salata C; Wallner O; Koolmeister T; Cazares-Korner A; Visnes T; Hesselman MC; Kunold E; Wiita E; Kalderen C; Lightowler M; Jemth A-S; Lehtio J; Rosenquist A; Warpman-Berglund U; Helleday T; Mirazimi A; Jafari R; Puumalainen M-R
Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(12):2047-2068
Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy
van Westering TLE; Johansson HJ; Hanson B; Coenen-Stass AML; Lomonosova Y; Tanihata J; Motohashi N; Yokota T; Takeda S; Lehtio J; Wood MJA; EL Andaloussi S; Aoki Y; Roberts TC
Journal article: BLOOD. 2020;136:10-11
Proteogenomic Subtyping of Chronic Lymphocytic Leukemia Identifies a Novel Poor Outcome Subgroup with a Distinct Drug Response Profile
Herbst SA; Vesterlund M; Jafari R; Siavelis I; Stahl M; Schitter E; Helmboldt AJ; Iskar M; Liebers N; Czernilofsky F; Roider T; Bruch P-M; Lu J; Richter S; Mermelekas G; Umer HM; Knoll M; Kolb C; Lenze A; Cao X; Osterholm-Corbascio C; Scheinost S; Ganzinger M; Mansouri L; Kriegsmann K; Kriegsmann M; Mueller-Tidow C; Dreger P; Anders S; Zapatka M; Herling M; Rosenquist R; Stilgenbauer S; Zenz T; Huber W; Tausch E; Lehtio J; Dietrich S
Journal article: PANCREATOLOGY. 2020;20:s129-s130
Elevated protein expression levels of KRAS in Pancreatic Ductal Adenocarcinoma (PDAC) are associated with better prognosis
Stålberg S; Silwal-Pandit L; Hamfjord J; Lehtiö J; Kure E
Article: NEOPLASIA. 2020;22(9):390-398
Ex vivo assessment of targeted therapies in a rare metastatic epithelial-myoepithelial carcinoma
Makela R; Arjonen A; Rahmanto AS; Harma V; Lehtio J; Kuopio T; Helleday T; Sangfelt O; Kononen J; Rantala JK
Article: BMC GENOMICS. 2020;21(1):590
Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity
Lytrivi M; Ghaddar K; Lopes M; Rosengren V; Piron A; Yi X; Johansson H; Lehtio J; Igoillo-Esteve M; Cunha DA; Marselli L; Marchetti P; Ortsater H; Eizirik DL; Cnop M
Article: ELIFE. 2020;9:e57894
PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer
Brunner A; Rahmanto AS; Johansson H; Franco M; Viiliainen J; Gazi M; Frings O; Fredlund E; Spruck C; Lehtio J; Rantala JK; Larsson L-G; Sangfelt O
Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(6):1047-1057
DEqMS: A Method for Accurate Variance Estimation in Differential Protein Expression Analysis
Zhu Y; Orre LM; Tran YZ; Mermelekas G; Johansson HJ; Malyutina A; Anders S; Lehtio J
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2020;8(1):e000204
In-depth plasma proteomics reveals increase in circulating PD-1 during anti-PD-1 immunotherapy in patients with metastatic cutaneous melanoma
Babacic H; Lehtio J; de Coana YP; Pernemalm M; Eriksson H
Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(4):608-623
Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics
Herr P; Bostrom J; Rullman E; Rudd SG; Vesterlund M; Lehtio J; Helleday T; Maddalo G; Altun M
Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
Article: CIRCULATION RESEARCH. 2020;126(5):571-585
PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling
Rykaczewska U; Suur BE; Rohl S; Razuvaev A; Lengquist M; Sabater-Lleal M; van der Laan SW; Miller CL; Wirka RC; Kronqvist M; Diez MG; Vesterlund M; Gillgren P; Odeberg J; Lindeman JH; Veglia F; Humphries SE; de Faire U; Baldassarre D; Tremoli E; Lehtio J; Hansson GK; Paulsson-Berne G; Pasterkamp G; Quertermous T; Hamsten A; Eriksson P; Hedin U; Matic L
Article: FRONTIERS IN ONCOLOGY. 2020;10:51
Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma
Rad Pour S; Morikawa H; Kiani NA; Gomez-Cabrero D; Hayes A; Zheng X; Pernemalm M; Lehtio J; Mole DJ; Hansson J; Eriksson H; Tegner J
Article: PLANT PHYSIOLOGY. 2019;181(4):1632-1650
A Mitochondrial LYR Protein Is Required for Complex I Assembly¹^[OPEN]
Ivanova A; Gill-Hille M; Huang S; Branca RM; Kmiec B; Teixeira PF; Lehtio J; Whelan J; Murcha MW
Article: AGING CELL. 2019;18(6):e13029
Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice
Ross JM; Coppotelli G; Branca RM; Kim KM; Lehtio J; Sinclair DA; Olson L
Article: ISCIENCE. 2019;21:188-204
MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting Neuroblastoma
Oliynyk G; Ruiz-Perez MV; Sainero-Alcolado L; Dzieran J; Zirath H; Gallart-Ayala H; Wheelock CE; Johansson HJ; Nilsson R; Lehtio J; Arsenian-Henriksson M
Article: SCIENTIFIC REPORTS. 2019;9(1):16504
Early symptoms and sensations as predictors of lung cancer: a machine learning multivariate model
Levitsky A; Pernemalm M; Bernhardson B-M; Forshed J; Kolbeck K; Olin M; Henriksson R; Lehtio J; Tishelman C; Eriksson LE
Journal article: ANNALS OF ONCOLOGY. 2019;30:v536
1316PD Plasma proteomics in patients with metastatic cutaneous melanoma treated with immune checkpoint inhibitors
Eriksson H; Babic H; Lehtiö J; Pernemalm M
Article: FASEB JOURNAL. 2019;33(9):10193-10206
Ouabain-regulated phosphoproteome reveals molecular mechanisms for Na⁺, K⁺-ATPase control of cell adhesion, proliferation, and survival
Panizza E; Zhang L; Fontana JM; Hamada K; Svensson D; Akkuratov EE; Scott L; Mikoshiba K; Brismar H; Lehtio J; Aperia A
Article: SCIENTIFIC REPORTS. 2019;9(1):8324
Systematic assessment of antibody selectivity in plasma based on a resource of enrichment profiles
Fredolini C; Bystrom S; Sanchez-Rivera L; Ioannou M; Tamburro D; Ponten F; Branca RM; Nilsson P; Lehtio J; Schwenk JM
Journal article: PANCREATOLOGY. 2019;19:s155
The cellular proteome of pancreatic ductal adenocarcinoma
Silwal-Pandit L; Johansson H; Stålberg SM; Mermelekas G; Lothe I-MB; Skrede ML; Dalsgaard AM; Helland Å; Skålhegg BS; Labori KJ; Lingjærde OC; Lehtiö J; Kure E
Article: NATURE COMMUNICATIONS. 2019;10(1):2331
The viral protein corona directs viral pathogenesis and amyloid aggregation
Ezzat K; Pernemalm M; Palsson S; Roberts TC; Jarver P; Dondalska A; Bestas B; Sobkowiak MJ; Levanen B; Skold M; Thompson EA; Saher O; Kari OK; Lajunen T; Ekstrom ES; Nilsson C; Ishchenko Y; Malm T; Wood MJA; Power UF; Masich S; Linden A; Sandberg JK; Lehtio J; Spetz A-L; EL Andaloussi S
Article: CLINICAL CANCER RESEARCH. 2019;25(10):3115-3127
Ultrasensitive Immunoprofiling of Plasma Extracellular Vesicles Identifies Syndecan-1 as a Potential Tool for Minimally Invasive Diagnosis of Glioma
Chandran VI; Welinder C; Mansson A-S; Offer S; Freyhult E; Pernemalm M; Lund SM; Pedersen S; Lehtio J; Marko-Varga G; Johansson MC; Englund E; Sundgren PC; Belting M
Article: NATURE COMMUNICATIONS. 2019;10(1):1600
Breast cancer quantitative proteome and proteogenomic landscape
Johansson HJ; Socciarelli F; Vacanti NM; Haugen MH; Zhu Y; Siavelis I; Fernandez-Woodbridge A; Aure MR; Sennblad B; Vesterlund M; Branca RM; Orre LM; Huss M; Fredlund E; Beraki E; Garred O; Boekel J; Sauer T; Zhao W; Nord S; Hoglander EK; Jans DC; Brismar H; Haukaas TH; Bathen TF; Schlichting E; Naume B; Geisler J; Hofvind S; Engebraten O; Geitvik GA; Langerod A; Karesen R; Maelandsmo GM; Sorlie T; Skjerven HK; Park D; Hartman-Johnsen O-J; Luders T; Borgen E; Kristensen VN; Russnes HG; Lingjaerde OC; Mills GB; Sahlberg KK; Borresen-Dale A-L; Lehtio J
Article: ELIFE. 2019;8:e41608
In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta
Pernemalm M; Sandberg A; Zhu Y; Boekel J; Tamburro D; Schwenk JM; Bjork A; Wahren-Herlenius M; Amark H; Ostenson C-G; Westgren M; Lehtio J
Article: NATURE COMMUNICATIONS. 2019;10(1):1519
Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia
Yang M; Vesterlund M; Siavelis I; Moura-Castro LH; Castor A; Fioretos T; Jafari R; Lilljebjorn H; Odom DT; Olsson L; Ravi N; Woodward EL; Harewood L; Lehtio J; Paulsson K
Journal article: FASEB JOURNAL. 2019;33:476.21
Ouabain Regulated Phosphoproteome Reveals Molecular Mechanisms Behind Na, K-ATPase Control of Cell Adhesion, Proliferation and Survival
Panizza E; Svensson D; Zhang L; Fontana JM; Akkuratov E; Scott L; Brismar H; Lehtio J; Aperia A
Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):62
Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjogren's syndrome differ in molecular signatures and treatment perspectives
Idborg H; Zandian A; Sandberg A-S; Nilsson B; Elvin K; Truedsson L; Sohrabian A; Ronnelid J; Mo J; Grosso G; Kvarnstrom M; Gunnarsson I; Lehtio J; Nilsson P; Svenungsson E; Jakobsson P-J
Article: MOLECULAR CELL. 2019;73(1):166-182.e7
SubCellBarCode: Proteome-wide Mapping of Protein Localization and Relocalization
Orre LM; Vesterlund M; Pan Y; Arslan T; Zhu Y; Woodbridge AF; Frings O; Fredlund E; Lehtio J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2708
TcellSubC: An Atlas of the Subcellular Proteome of Human T Cells
Joshi RN; Stadler C; Lehmann R; Lehtio J; Tegner J; Schmidt A; Vesterlund M
Journal article: INNOVATION IN AGING. 2018;2(suppl_1):334
USING PROTEOMICS TO ELUCIDATE HOW VOLUNTARY EXERCISE COMBATS AGING PHENOTYPES IN MTDNA MUTATOR MICE
Ross JM; Coppotelli G; Branca R; Lehtiö J; Sinclair D; Olson L
Article: PLANT JOURNAL. 2018;96(4):705-715
Accumulation of endogenous peptides triggers a pathogen stress response in Arabidopsis thaliana
Kmiec B; Branca RMM; Berkowitz O; Li L; Wang Y; Murcha MW; Whelan J; Lehtioe J; Glaser E; Teixeira PF
Article: SCIENTIFIC REPORTS. 2018;8(1):15841
Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis
Jarver P; Dondalska A; Poux C; Sandberg A; Bergenstrahle J; Skold AE; Dereuddre-Bosquet N; Martinon F; Palsson S; Zaghloul E; Brodin D; Sander B; Lennox KA; Behlke MA; EL-Andaloussi S; Lehtio J; Lundeberg J; LeGrand R; Spetz A-L
Article: CELL DEATH & DISEASE. 2018;9(9):846
Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment
Dyczynski M; Vesterlund M; Bjorklund A-C; Zachariadis V; Janssen J; Gallart-Ayala H; Daskalaki E; Wheelock CE; Lehtio J; Grander D; Tamm KP; Nilsson R
Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):464-480
Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage
Matic LP; Iglesias MJ; Vesterlund M; Lengquist M; Hong M-G; Saieed S; Sanchez-Rivera L; Berg M; Razuvaev A; Kronqvist M; Lund K; Caidahl K; Gillgren P; Ponten F; Uhlen M; Schwenk JM; Hansson GK; Paulsson-Berne G; Fagman E; Roy J; Hultgren R; Bergstrom G; Lehtio J; Odeberg J; Hedin U
Article: SCIENTIFIC REPORTS. 2018;8(1):10813
Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome
Sork H; Corso G; Krjutskov K; Johansson HJ; Nordin JZ; Wiklander OPB; Lee YXF; Westholm JO; Lehtio J; Wood MJA; Mager I; El Andaloussi S
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2018;470:84-95
Molecular profiles of oxyphilic and chief cell parathyroid adenoma
Lu M; Kjellin H; Fotouhi O; Lee L; Nilsson I-L; Haglund F; Hoog A; Lehtio J; Larsson C
Article: NATURE BIOTECHNOLOGY. 2018;36(6):521-529
A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility
Wei B; Jolma A; Sahu B; Orre LM; Zhong F; Zhu F; Kivioja T; Sur I; Lehtio J; Taipale M; Taipale J
Article: SCIENTIFIC REPORTS. 2018;8(1):9182
Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin
Johansson HJ; Vallhov H; Holm T; Gehrmann U; Andersson A; Johansson C; Blom H; Carroni M; Lehtio J; Scheynius A
Article: BMC BIOLOGY. 2018;16(1):47
Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3
Schmidt A; Marabita F; Kiani NA; Gross CC; Johansson HJ; Elias S; Rautio S; Eriksson M; Fernandes SJ; Silberberg G; Ullah U; Bhatia U; Lahdesmaki H; Lehtio J; Gomez-Cabrero D; Wiendl H; Lahesmaa R; Tegner J
Article: NATURE COMMUNICATIONS. 2018;9(1):903
Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow
Zhu Y; Orre LM; Johansson HJ; Huss M; Boekel J; Vesterlund M; Fernandez-Woodbridge A; Branca RMM; Lehtio J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(6):E1229-E1238
MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling
Dzieran J; Garcia AR; Westermark UK; Henley AB; Sanchez EE; Trager C; Johansson HJ; Lehtio J; Arsenian-Henriksson M
Article: MOLECULAR PLANT. 2018;11(2):342-345
A Common Peptidolytic Mechanism for Targeting Peptide Degradation in Mitochondria and Chloroplasts
Kmiec B; Branca RMM; Murcha MW; Lehtio J; Glaser E; Teixeira PF
Article: JOURNAL OF MOLECULAR BIOLOGY. 2018;430(3):348-362
Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin
Teixeira PF; Masuyer G; Pinho CM; Branca RMM; Kmiec B; Wallin C; Warmlander SKTS; Berntsson RP-A; Ankarcrona M; Graslund A; Lehtio J; Stenmark P; Glaser E
Article: BRAIN. 2018;141(2):582-595
Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach
Bereczki E; Branca RM; Francis PT; Pereira JB; Baek J-H; Hortobagyi T; Winblad B; Ballard C; Lehtio J; Aarsland D
Article: SCIENTIFIC REPORTS. 2018;8(1):498
Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications
Nassa G; Giurato G; Cimmino G; Rizzo F; Ravo M; Salvati A; Nyman TA; Zhu Y; Vesterlund M; Lehtio J; Golino P; Weisz A; Tarallo R
Article: ADVANCES IN BIOLOGICAL REGULATION. 2018;67:128-133
Normalization of mass spectrometry data (NOMAD).
Murie C; Sandri B; Sandberg A-S; Griffin TJ; Lehtiö J; Wendt C; Larsson O
Article: SCIENTIFIC REPORTS. 2017;7(1):15453
Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema
Egana I; Kaito H; Nitzsche A; Becker L; Ballester-Lopez C; Niaudet C; Petkova M; Liu W; Vanlandewijck M; Vernaleken A; Klopstock T; Fuchs H; Gailus-Durner V; de Angelis MH; Rask-Andersen H; Johansson HJ; Lehtio J; He L; Yildirim AO; Hellstrom M
Journal article: NEUROMUSCULAR DISORDERS. 2017;27:s167-s168
Comparative high resolution proteomic analysis of dystrophic mouse models reveals a core dystrophic proteome and the impact of aging
van Westering T; Johanson H; Coenen-Stass A; Miyatake S; Tanihata J; Takeda S; Yokota T; Lehtio J; Wood M; El Andaloussi S; Roberts T; Aoki Y
Article: ONCOTARGET. 2017;8(44):77061-77074
Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization
Zhao M; Spiess M; Johansson HJ; Olofsson H; Hu J; Lehtio J; Stromblad S
Article: BMC CANCER. 2017;17(1):650
Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes metastasis-related properties via TGFβ2/TβR and CD44 in MDA-MB-231 breast cancer cells
Reithmeier A; Panizza E; Krumpel M; Orre LM; Branca RMM; Lehtio J; Ek-Rylander B; Andersson G
Article: CELL DEATH & DISEASE. 2017;8(8):e3029
Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells
Azimi A; Tuominen R; Svedman FC; Caramuta S; Pernemalm M; Stolt MF; Kanter L; Kharaziha P; Lehtio J; Johansson CH; Holom V; Hansson J; Brage SE
Article: ANALYTICAL CHEMISTRY. 2017;89(14):7356-7364
Tuning Metabolome Coverage in Reversed Phase LC-MS Metabolomics of MeOH Extracted Samples Using the Reconstitution Solvent Composition
Lindahl A; Saaf S; Lehtio J; Nordstrom A
Article: SCIENTIFIC REPORTS. 2017;7(1):4513
Isoelectric point-based fractionation by HiRIEF coupled to LC-MS allows for in-depth quantitative analysis of the phosphoproteome
Panizza E; Branca RMM; Oliviusson P; Orre LM; Lehtio J
Article: NUCLEIC ACIDS RESEARCH. 2017;45(5):2629-2643
Proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of Malassezia sympodialis
Zhu Y; Engstrom PG; Tellgren-Roth C; Baudo CD; Kennell JC; Sun S; Billmyre RB; Schroder MS; Andersson A; Holm T; Sigurgeirsson B; Wu G; Sankaranarayanan SR; Siddharthan R; Sanyal K; Lundeberg J; Nystedt B; Boekhout T; Dawson TLJ; Heitman J; Scheynius A; Lehtio J
Journal article: NEUROMUSCULAR DISORDERS. 2017;27:s5-s6
D02 Age-related and mutation-independent proteomic changes in dystrophic mouse muscle
van Westering TLE; Johansson HJ; Coenen-Stass AML; Tanihata J; Takeda S; Yokota T; Lehtiö J; Wood MJA; Andaloussi SE; Roberts TC; Aoki Y
Article: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS. 2017;14(2):272-281
Optimizing Analytical Depth and Cost Efficiency of IEF-LC/MS Proteomics
Kifer I; Branca RM; Ben-Dor A; Zhai L; Xu P; Lehtio J; Yakhini Z
Article: METABOLOMICS. 2017;13(5):61
Discrimination of pancreatic cancer and pancreatitis by LC-MS metabolomics
Lindahl A; Heuchel R; Forshed J; Lehtio J; Lohr M; Nordstrom A
Article: NATURE CHEMICAL BIOLOGY. 2017;13(1):15-17
A multi-step peptidolytic cascade for amino acid recovery in chloroplasts
Teixeira PF; Kmiec B; Branca RMM; Murcha MW; Byzia A; Ivanova A; Whelan J; Drag M; Lehtio J; Glaser E
Journal article: CHINESE NEUROSURGICAL JOURNAL. 2016;2(1):36
Mesenchymal stem cell-based therapy for ischemic stroke
Anderson JD; Pham MT; Contreras Z; Hoon M; Fink KD; Johansson HJ; Rossignol J; Dunbar GL; Showalter M; Fiehn O; Bramlett CS; Bardini RL; Bauer G; Fury B; Hendrix KJ; Chedin F; EL-Andaloussi S; Hwang B; Mulligan MS; Lehtiö J; Nolta JA
Article: ANNALS OF ONCOLOGY. 2016;27(12):2275-2283
Validation and development of MTH1 inhibitors for treatment of cancer
Berglund UW; Sanjiv K; Gad H; Kalderen C; Koolmeister T; Pham T; Gokturk C; Jafari R; Maddalo G; Seashore-Ludlow B; Chernobrovkin A; Manoilov A; Pateras IS; Rasti A; Jemth A-S; Almlof I; Loseva O; Visnes T; Einarsdottir BO; Gaugaz FZ; Saleh A; Platzack B; Wallner OA; Vallin KSA; Henriksson M; Wakchaure P; Borhade S; Herr P; Kallberg Y; Baranczewski P; Homan EJ; Wiita E; Nagpal V; Meijer T; Schipper N; Rudd SG; Brautigam L; Lindqvist A; Filppula A; Lee T-C; Artursson P; Nilsson JA; Gorgoulis VG; Lehtio J; Zubarev RA; Scobie M; Helleday T
Article: SCIENTIFIC REPORTS. 2016;6:35712
Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves
Maleki S; Kjellqvist S; Paloschi V; Magne J; Branca RMM; Du L; Hultenby K; Petrini J; Fuxe J; Lehtio J; Franco-Cereceda A; Eriksson P; Bjorck HM
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2016;101(10):3616-3627
Proteomics Suggests a Role for APC-Survivin in Response to Somatostatin Analog Treatment of Neuroendocrine Tumors
Fotouhi O; Kjellin H; Larsson C; Hashemi J; Barriuso J; Juhlin CC; Lu M; Hoog A; Pastrian LG; Lamarca A; Heredia Soto V; Zedenius J; Mendiola M; Lehtio J; Kjellman M
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(9):1947-1961
Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM
Matic LP; Rykaczewska U; Razuvaev A; Sabater-Lleal M; Lengquist M; Miller CL; Ericsson I; Rohl S; Kronqvist M; Aldi S; Magne J; Paloschi V; Vesterlund M; Li Y; Jin H; Diez MG; Roy J; Baldassarre D; Veglia F; Humphries SE; de Faire U; Tremoli E; Odeberg J; Vukojevic V; Lehtio J; Maegdefessel L; Ehrenborg E; Paulsson-Berne G; Hansson GK; Lindeman JHN; Eriksson P; Quertermous T; Hamsten A; Hedin U
Article: NUCLEIC ACIDS RESEARCH. 2016;44(14):6756-6769
Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression
Ivanov M; Kals M; Lauschke V; Barragan I; Ewels P; Kaller M; Axelsson T; Lehtio J; Milani L; Ingelman-Sundberg M
Article: ONCOTARGET. 2016;7(16):21332-21346
Genetic and epigenetic background and protein expression profiles in relation to telomerase activation in medullary thyroid carcinoma
Wang N; Kjellin H; Sofiadis A; Fotouhi O; Juhlin CC; Backdahl M; Zedenius J; Xu D; Lehtio J; Larsson C
Article: SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES. 2016;33(1):17-28
ALTERATIONS IN THE MEMBRANE-ASSOCIATED PROTEOME FRACTION OF ALVEOLAR MACROPHAGES IN SARCOIDOSIS
Kjellin H; Silva E; Branca RM; Eklund A; Jakobsson P-J; Grunewald J; Lehtio J; Wheelock AM
Article: SCIENTIFIC REPORTS. 2016;6:22519
Cells release subpopulations of exosomes with distinct molecular and biological properties
Willms E; Johansson HJ; Mager I; Lee Y; Blomberg KEM; Sadik M; Alaarg A; Smith CIE; Lehtio J; Andaloussi SEL; Wood MJA; Vader P
Article: STEM CELLS. 2016;34(3):601-613
Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling
Anderson JD; Johansson HJ; Graham CS; Vesterlund M; Pham MT; Bramlett CS; Montgomery EN; Mellema MS; Bardini RL; Contreras Z; Hoon M; Bauer G; Fink KD; Fury B; Hendrix KJ; Chedin F; El-Andaloussi S; Hwang B; Mulligan MS; Lehtio J; Nolta JA
Article: HUMAN MOLECULAR GENETICS. 2015;24(23):6756-6768
Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration
Roberts TC; Johansson HJ; McClorey G; Godfrey C; Blomberg KEM; Coursindel T; Gait MJ; Smith CIE; Lehtio J; El Andaloussi S; Wood MJA
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(42):25254-25272
Structural Basis for Oxygen Activation at a Heterodinuclear Manganese/Iron Cofactor
Griese JJ; Kositzki R; Schrapers P; Branca RMM; Nordstrom A; Lehtio J; Haumann M; Hogbom M
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(10):1199-1213
In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome
Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalen M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Haegglund H; Mattsson M; Lentio J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Article: EXPERIMENTAL CELL RESEARCH. 2015;336(1):158-170
Secretome protein signature of human gastrointestinal stromal tumor cells
Berglund E; Dare E; Branca RMM; Akcakaya P; Frobom R; Berggren P-O; Lui W-O; Larsson C; Zedenius J; Orre L; Lehtio J; Kim J; Branstrom R
Article: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. 2015;11(4):879-883
Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties
Nordin JZ; Lee Y; Vader P; Maeger I; Johansson HJ; Heusermann W; Wiklander OPB; Hallbrink M; Seow Y; Bultema JJ; Gilthorpe J; Davies T; Fairchild PJ; Gabrielsson S; Meisner-Kober NC; Lehtio J; Smith CIE; Wood MJA; Andaloussi SEL
Article: NATURE MEDICINE. 2015;21(4):314-317
RIFINs are adhesins implicated in severe Plasmodium falciparum malaria
Goel S; Palmkvist M; Moll K; Joannin N; Lara P; Akhouri RR; Moradi N; Ojemalm K; Westman M; Angeletti D; Kjellin H; Lehtio J; Blixt O; Idestrom L; Gahmberg CG; Storry JR; Hult AK; Olsson ML; von Heijne G; Nilsson I; Wahlgren M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(13):8348-8359
Rewired Metabolism in Drug-resistant Leukemia Cells A METABOLIC SWITCH HALLMARKED BY REDUCED DEPENDENCE ON EXOGENOUS GLUTAMINE
Staeubert C; Bhuiyan H; Lindahl A; Broom OJ; Zhu Y; Islam S; Linnarsson S; Lehtio J; Nordstrom A
Article: CLINICAL PROTEOMICS. 2015;12(1):8
Proteomics profiling identify CAPS as a potential predictive marker of tamoxifen resistance in estrogen receptor positive breast cancer
Johansson HJ; Sanchez BC; Forshed J; Stal O; Fohlin H; Lewensohn R; Hall P; Bergh J; Lehtio J; Linderholm BK
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26883
Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles
Li J; Lee Y; Johansson HJ; Maeger I; Vader P; Nordin JZ; Wiklander OPB; Lehtio J; Wood MJA; Andaloussi SEL
Article: PLOS ONE. 2015;10(5):e0126472
Differential Protein Expression Profiles of Cyst Fluid from Papillary Thyroid Carcinoma and Benign Thyroid Lesions
Dinets A; Pernemalm M; Kjellin H; Sviatoha V; Sofiadis A; Juhlin CC; Zedenius J; Larsson C; Lehtio J; Hoog A
Article: PLOS ONE. 2015;10(10):e0129008
Proteomics Analysis Reveals Distinct Corona Composition on Magnetic Nanoparticles with Different Surface Coatings: Implications for Interactions with Primary Human Macrophages
Vogt C; Pernemalm M; Kohonen P; Laurent S; Hultenby K; Vahter M; Lehtio J; Toprak MS; Fadeel B
Article: BIOMED RESEARCH INTERNATIONAL. 2015;2015:462549-13
Identifying and Assessing Interesting Subgroups in a Heterogeneous Population
Lee W; Alexeyenko A; Pernemalm M; Guegan J; Dessen P; Lazar V; Lehtio J; Pawitan Y
Article: JOURNAL OF PROTEOME RESEARCH. 2014;13(10):4424-4435
Investigating the Applicability of Antibodies Generated within the Human Protein Atlas as Capture Agents in Immunoenrichment Coupled to Mass Spectrometry
Bostrom T; Johansson HJ; Lehtio J; Uhlen M; Hober S
Article: MOLECULAR & CELLULAR PROTEOMICS. 2014;13(6):1611-1624
Immunoproteomics Using Polyclonal Antibodies and Stable Isotope-labeled Affinity-purified Recombinant Proteins
Edfors F; Bostroem T; Forsstroem B; Zeiler M; Johansson H; Lundberg E; Hober S; Lehtio J; Mann M; Uhlen M
Article: MOLECULAR & CELLULAR PROTEOMICS. 2014;13(6):1552-1562
SpliceVista, a Tool for Splice Variant Identification and Visualization in Shotgun Proteomics Data
Zhu Y; Hultin-Rosenberg L; Forshed J; Branca RMM; Orre LM; Lehtio J
Article: BRITISH JOURNAL OF CANCER. 2014;110(10):2489-2495
Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance
Azimi A; Pernemalm M; Stolt MF; Hansson J; Lehtio J; Brage SE; Johansson CH
Article: MOLECULAR & CELLULAR PROTEOMICS. 2014;13(3):701-715
Proteome Screening of Pleural Effusions Identifies Galectin 1 as a Diagnostic Biomarker and Highlights Several Prognostic Biomarkers for Malignant Mesothelioma
Mundt F; Johansson HJ; Forshed J; Arslan S; Metintas M; Dobra K; Lehtio J; Hjerpe A
Article: JOURNAL OF PROTEOMICS. 2014;96:133-144
Quantitative accuracy in mass spectrometry based proteomics of complex samples: The impact of labeling and precursor interference
Sandberg A; Branca RMM; Lehtio J; Forshed J
Article: PLOS ONE. 2014;9(2):e87951
Differentially Expressed Proteins in Malignant and Benign Adrenocortical Tumors
Kjellin H; Johansson H; Hoog A; Lehtio J; Jakobsson P-J; Kjellman M
Article: NATURE METHODS. 2014;11(1):59-62
HiRIEF LC-MSMS enables deep proteome coverage and unbiased proteogenomics
Branca RMM; Orre LM; Johansson HJ; Granholm V; Huss M; Perez-Bercoff A; Forshed J; Kall L; Lehtio J
Article: ONCOGENE. 2013;32(49):5531-5540
S100A4 interacts with p53 in the nucleus and promotes p53 degradation
Orre LM; Panizza E; Kaminskyy VO; Vernet E; Graslund T; Zhivotovsky B; Lehtio J
Article: BMC MEDICAL GENOMICS. 2013;6:53
Integrated molecular portrait of non-small cell lung cancers
Lazar V; Suo C; Orear C; van den Oord J; Balogh Z; Guegan J; Job B; Meurice G; Ripoche H; Calza S; Hasmats J; Lundeberg J; Lacroix L; Vielh P; Dufour F; Lehtio J; Napieralski R; Eggermont A; Schmitt M; Cadranel J; Besse B; Girard P; Blackhall F; Validire P; Soria J-C; Dessen P; Hansson J; Pawitan Y
Article: PROTEOMICS. 2013;13(23-24):3406-3410
Selectivity analysis of single binder assays used in plasma protein profiling
Neiman M; Fredolini C; Johansson H; Lehtio J; Nygren P-A; Uhlen M; Nilsson P; Schwenk JM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(43):17189-17194
Direct observation of structurally encoded metal discrimination and ether bond formation in a heterodinuclear metalloprotein
Griese JJ; Roos K; Cox N; Shafaat HS; Branca RMM; Lehtio J; Graslund A; Lubitz W; Siegbahn PEM; Hogbom M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(40):e3761-e3769
Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts
Kmiec B; Teixeira PF; Berntsson RP-A; Murcha MW; Branca RMM; Radomiljac JD; Regberg J; Svensson LM; Bakali A; Langel U; Lehtio J; Whelan J; Stenmark P; Glaser E
Article: JOURNAL OF PROTEOME RESEARCH. 2013;12(9):3934-3943
Quantitative Proteomics Profiling of Primary Lung Adenocarcinoma Tumors Reveals Functional Perturbations in Tumor Metabolism
Pernemalm M; De Petris L; Branca RM; Forshed J; Kanter L; Soria J-C; Girard P; Validire P; Pawitan Y; van den Oord J; Lazar V; Pahlman S; Lewensohn R; Lehtio J
Article: MOLECULAR & CELLULAR PROTEOMICS. 2013;12(7):2021-2031
Defining, Comparing, and Improving iTRAQ Quantification in Mass Spectrometry Proteomics Data
Hultin-Rosenberg L; Forshed J; Branca RMM; Lehtio J; Johansson HJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(25):10258-10263
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
Zirath H; Frenzel A; Oliynyk G; Segerstrom L; Westermark UK; Larsson K; Persson MM; Hultenby K; Lehtio J; Einvik C; Pahlman S; Kogner P; Jakobsson P-J; Henriksson MA
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:a466
FRI0271 Stratification of sle patients for improved diagnosis and treatment
Idborg H; Rännar S; Oliynyk G; Forshed J; Branca RM; Donten M; Bennett K; Gustafsson J; Vikerfors A; Elvin K; Truedsson L; Nilsson B; Gunnarsson I; Trygg J; Lehtiö J; Lundstedt T; Svenungsson E; Jakobsson P-J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(22):15556-15570
Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis IMPLICATION FOR ALZHEIMER DISEASE
Tang Z; Bereczki E; Zhang H; Wang S; Li C; Ji X; Branca RM; Lehtio J; Guan Z; Filipcik P; Xu S; Winblad B; Pei J-J
Article: JOURNAL OF PROTEOME RESEARCH. 2013;12(2):1014-1019
A Novel Prefractionation Method Combining Protein and Peptide Isoelectric Focusing in Immobilized pH Gradient Strips
Pernemalm M; Lehtio J
Article: MOLECULAR & CELLULAR PROTEOMICS. 2013;12(2):407-425
A Combined Proteomic and Transcriptomic Approach Shows Diverging Molecular Mechanisms in Thoracic Aortic Aneurysm Development in Patients with Tricuspid- And Bicuspid Aortic Valve
Kjellqvist S; Maleki S; Olsson T; Chwastyniak M; Branca RMM; Lehtio J; Pinet F; Franco-Cereceda A; Eriksson P
Article: MBIO. 2013;4(1):e00572-e00512
Genomic Insights into the Atopic Eczema-Associated Skin Commensal Yeast Malassezia sympodialis
Gioti A; Nystedt B; Li W; Xu J; Andersson A; Averette AF; Muench K; Wang X; Kappauf C; Kingsbury JM; Kraak B; Walker LA; Johansson HJ; Holm T; Lehtio J; Stajich JE; Mieczkowski P; Kahmann R; Kennell JC; Cardenas ME; Lundeberg J; Saunders CW; Boekhout T; Dawson TL; Munro CA; de Groot PWJ; Butler G; Heitman J; Scheynius A
Article: NATURE COMMUNICATIONS. 2013;4:2175
Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer
Johansson HJ; Sanchez BC; Mundt F; Forshed J; Kovacs A; Panizza E; Hultin-Rosenberg L; Lundgren B; Martens U; Mathe G; Yakhini Z; Helou K; Krawiec K; Kanter L; Hjerpe A; Stal O; Linderholm BK; Lehtio J
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2012;53(11):2188-2195
In vitro oxidative inactivation of human presequence protease (hPreP)
Teixeira PF; Pinho CM; Branca RM; Lehtio J; Levine RL; Glaser E
Article: BMC BIOINFORMATICS. 2012;13:226
Network enrichment analysis: extension of gene-set enrichment analysis to gene networks
Alexeyenko A; Lee W; Pernemalm M; Guegan J; Dessen P; Lazar V; Lehtio J; Pawitan Y
Article: MOLECULAR & CELLULAR PROTEOMICS. 2012;11(7):M112.016998
Tumor Proteomics by Multivariate Analysis on Individual Pathway Data for Characterization of Vulvar Cancer Phenotypes
Sandberg A; Lindell G; Kallstrom BN; Branca RM; Danielsson KG; Dahlberg M; Larson B; Forshed J; Lehtio J
Journal article: ANNALS OF ONCOLOGY. 2012;23:v33-v34
P3.04 Genome Wide Proteomics Using Peptide High Resolution Isoelectric Focusing Hirief-Ms Allows Detection New Human Gene Models
Lehtiö J; Branca M; Johansson H; Orre M; Granholm V; Forshed J; Perez-Bercoff M; Käll L
Journal article: ANNALS OF ONCOLOGY. 2012;23:v38
P4.02 Proteomics Anchored Systems Biology Analysis of Prognostic Factors in Primary Lung Adenocarcinoma Tumours
Pernemalm A; Branca M; Petris DE; Forshed J; Lewensohn R; Besse B; Lazar V; Van den Oord J; Pawitan Y; Lehtiö J
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2012;113(5):1635-1644
Thapsigargin down-regulates protein levels of GRP78/BiP in INS-1E cells
Rosengren V; Johansson H; Lehtio J; Fransson L; Sjoholm A; Ortsater H
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2012;166(4):657-667
Proteomic profiling of follicular and papillary thyroid tumors
Sofiadis A; Becker S; Hellman U; Hultin-Rosenberg L; Dinets A; Hulchiy M; Zedenius J; Wallin G; Foukakis T; Hoog A; Auer G; Lehtio J; Larsson C
Article: NATURE COMMUNICATIONS. 2012;3:976
Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway
Arabi A; Ullah K; Branca RMM; Johansson J; Bandarra D; Haneklaus M; Fu J; Aries I; Nilsson P; Den Boer ML; Pokrovskaja K; Grander D; Xiao G; Rocha S; Lehtio J; Sangfelt O
Journal article: JOURNAL OF PROTEOME RESEARCH. 2011;10(10):4884
Phosphoproteomic Profiling of NSCLC Cells Reveals That Ephrin B3 Regulates Pro-survival Signaling through Aktl-Mediated Phosphorylation of the EphA2 Receptor (vol 10, pg 2566, 2011)
Stahl S; Branca RM; Efazat G; Ruzzene M; Zhivotovsky B; Lewensohn R; Viktorsson K; Lehtio J
Article: MOLECULAR & CELLULAR PROTEOMICS. 2011;10(10):M111.010264
Enhanced Information Output From Shotgun Proteomics Data by Protein Quantification and Peptide Quality Control (PQPQ)
Forshed J; Johansson HJ; Pernemalm M; Branca RMM; Sandberg A; Lehtio J
Article: PROTEIN SCIENCE. 2011;20(9):1520-1529
Penicillin-binding protein 5 can form a homo-oligomeric complex in the inner membrane of Escherichia coli
Skoog K; Bruzell FS; Ducroux A; Hellberg M; Johansson H; Lehtio J; Hogbom M; Daley DO
Article: JOURNAL OF PROTEOME RESEARCH. 2011;10(6):2703-2714
Identification of Chromatophore Membrane Protein Complexes Formed under Different Nitrogen Availability Conditions in Rhodospirillum rubrum
Selao TT; Branca R; Chae PS; Lehtio J; Gellman SH; Rasmussen SGF; Nordlund S; Noren A
Article: JOURNAL OF PROTEOME RESEARCH. 2011;10(5):2566-2578
Phosphoproteomic Profiling of NSCLC Cells Reveals that Ephrin B3 Regulates Pro-survival Signaling through Akt1-Mediated Phosphorylation of the EphA2 Receptor
Stahl S; Branca RM; Efazat G; Ruzzene M; Zhivotovsky B; Lewensohn R; Viktorsson K; Lehtio J
Article: NUCLEIC ACIDS RESEARCH. 2011;39(9):3972-3987
Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo
Andaloussi SEL; Lehto T; Maeger I; Rosenthal-Aizman K; Oprea II; Simonson OE; Sork H; Ezzat K; Copolovici DM; Kurrikoff K; Viola JR; Zaghloul EM; Sillard R; Johansson HJ; Hassane FS; Guterstam P; Suhorutsenko J; Moreno PMD; Oskolkov N; Haelldin J; Tedebark U; Metspalu A; Lebleu B; Lehtioe J; Smith CIE; Langel U
Article: JOURNAL OF PROTEOME RESEARCH. 2011;10(4):1848-1859
Systematic Analysis of Native Membrane Protein Complexes in Escherichia coli
Maddalo G; Stenberg-Bruzell F; Gotzke H; Toddo S; Bjorkholm P; Eriksson H; Chovanec P; Genevaux P; Lehtio J; Ilag LL; Daley DO
Article: AMINO ACIDS. 2011;40(2):697-711
Observed peptide pI and retention time shifts as a result of post-translational modifications in multidimensional separations using narrow-range IPG-IEF
Lengqvist J; Eriksson H; Gry M; Uhlen K; Bjorklund C; Bjellqvist B; Jakobsson P-J; Lehtio J
Article: BREAST CANCER RESEARCH AND TREATMENT. 2011;125(2):457-465
Vascular endothelial growth factor receptor 2 and downstream p38 mitogen-activated protein kinase are possible candidate markers of intrinsic resistance to adjuvant endocrine treatment in steroid receptor positive breast cancer
Linderholm BK; Hellborg H; Johansson U; Skoog L; Lehtio J
Article: EUROPEAN JOURNAL OF CANCER. 2011;47(1):131-137
Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer
De Petris L; Branden E; Herrmann R; Sanchez BC; Koyi H; Linderholm B; Lewensohn R; Linder S; Lehtio J
Article: THYROID. 2010;20(10):1067-1076
Proteomic Study of Thyroid Tumors Reveals Frequent Up-Regulation of the Ca²⁺-Binding Protein S100A6 in Papillary Thyroid Carcinoma
Sofiadis A; Dinets A; Orre LM; Branca RM; Juhlin CC; Foukakis T; Wallin G; Hoog A; Hulchiy M; Zedenius J; Larsson C; Lehtio J
Article: BMC BIOINFORMATICS. 2010;11:468
Multivariate meta-analysis of proteomics data from human prostate and colon tumours
Rosenberg LH; Franzen B; Auer G; Lehtio J; Forshed J
Article: PROTEOME SCIENCE. 2010;8:9
A novel method for sample preparation of fresh lung cancer tissue for proteomics analysis by tumor cell enrichment and removal of blood contaminants
De Petris L; Pernemalm M; Elmberger G; Bergman P; Orre L; Lewensohn R; Lehtio J
Article: PROTEOME SCIENCE. 2009;7:43
A comparison between protein profiles of B cell subpopulations and mantle cell lymphoma cells
Stranneheim H; Orre LM; Lehtio J; Flygare J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(41):27827-27837
N^α-Tosyl-L-phenylalanine Chloromethyl Ketone Induces Caspase-dependent Apoptosis in Transformed Human B Cell Lines with Transcriptional Down-regulation of Anti-apoptotic HS1-associated Protein X-1
Jitkaew S; Trebinska A; Grzybowska E; Carlsson G; Nordstrom A; Lehtio J; Frojmark A-S; Dahl N; Fadeel B
Article: ANNALS OF ONCOLOGY. 2009;20(10):1639-1646
Significantly higher levels of vascular endothelial growth factor (VEGF) and shorter survival times for patients with primary operable triple-negative breast cancer
Linderholm BK; Hellborg H; Johansson U; Elmberger G; Skoog L; Lehtio J; Lewensohn R
Article: BMC BIOINFORMATICS. 2009;10:272
Correlating gene and protein expression data using Correlated Factor Analysis
Tan CS; Salim A; Ploner A; Lehtio J; Chia KS; Pawitan Y
Article: PROTEOMICS. 2009;9(13):3414-3424
Use of narrow-range peptide IEF to improve detection of lung adenocarcinoma markers in plasma and pleural effusion
Pernemalm M; De Petris L; Eriksson H; Branden E; Koyi H; Kanter L; Lewensohn R; Lehtio J
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2009;877(13):1306-1316
Robustness and accuracy of high speed LC-MS separations for global peptide quantitation and biomarker discovery
Lengqvist J; Andrade J; Yang Y; Alvelius G; Lewensohn R; Lehtio J
Article: MOLECULAR & CELLULAR PROTEOMICS. 2009;8(5):1117-1129
Proteomics and Pathway Analysis Identifies JNK Signaling as Critical for High Linear Energy Transfer Radiation-induced Apoptosis in Non-small Lung Cancer Cells
Stahl S; Fung E; Adams C; Lengqvist J; Mork B; Stenerlow B; Lewensohn R; Lehtio J; Zubarev R; Viktorsson K
Article: LUNG CANCER. 2009;63(3):410-417
Tumor expression of S100A6 correlates with survival of patients with stage I non-small-cell lung cancer
De Petris L; Orre LM; Kanter L; Pernemalm M; Koyi H; Lewensohn R; Lehtio J
Article: PROTEOMICS. 2008;8(15):3008-3018
Quantitative membrane proteomics applying narrow range peptide isoelectric focusing for studies of small cell lung cancer resistance mechanisms
Eriksson H; Lengqvist J; Hedlund J; Uhlen K; Orre LM; Bjellqvist B; Persson B; Lehtio J; Jakobsson P-J
Article: JOURNAL OF PROTEOME RESEARCH. 2008;7(7):2712-2722
Evaluation of three principally different intact protein prefractionation methods for plasma biomarker discovery
Pernemalm M; Orre LM; Lengqvist J; Wikstrom P; Lewensohn R; Lehtio J
Article: JOURNAL OF PROTEOME RESEARCH. 2008;7(6):2332-2341
Proteomic data analysis workflow for discovery of candidate biomarker peaks predictive of clinical outcome for patients with acute myeloid leukemia
Forshed J; Pernemalm M; Tan CS; Lindberg M; Kanter L; Pawitan Y; Lewensohn R; Stenke L; Lehtio J
Article: ANALYTICAL CHEMISTRY. 2008;80(2):421-429
Multiple ionization mass spectrometry strategy used to reveal the complexity of metabolomics
Nordstrom A; Want E; Northen T; Lehtioe J; Siuzdak G
Article: MOLECULAR & CELLULAR PROTEOMICS. 2007;6(12):2122-2131
Up-regulation, modification, and translocation of S100A6 induced by exposure to ionizing radiation revealed by proteomics profiling
Orre LM; Pernemalm M; Lengqvist J; Lewensohn R; Lehtio J
Article: JOURNAL OF BIOTECHNOLOGY. 2006;126(4):582-586
Pre-fractionation of archival frozen turnours for proteomics applications
Forsberg L; Larsson C; Sofiadis A; Lewensohn R; Hoog A; Lehtio J
Article: PROTEOMICS. 2006;6(23):6124-6133
Annotated regions of significance of SELDI-TOF-MS spectra for detecting protein biornarkers
Tan CS; Ploner A; Quandt A; Lehtio J; Pernemalm M; Lewensohn R; Pawitan Y
Journal article: BLOOD. 2006;108(11):4436
Global Proteomics in AML: Using SELDI-TOF MS on Diagnostic Samples To Identify Spectra and Protein Biomarkers Indicative of Prognosis.
Stenke L; Pernemalm M; Forshed J; Pawitan Y; Lagergren-Lindberg M; Kanter L; Lehtiö J
Article: BIOINFORMATICS. 2006;22(12):1515-1523
Finding regions of significance in SELDI measurements for identifying protein biomarkers
Tan CS; Ploner A; Quandt A; Lehtio J; Pawitan Y
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;342(4):1211-1217
p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line
Orre LM; Stenerlöw B; Dhar S; Larsson R; Lewensohn R; Lehtiö J
Journal article: BLOOD. 2005;106(11):2367
Detection of Proteins Related to Therapeutic Outcome, Including Drug Resistance, in Acute Myeloid Leukemia Using Mass Spectrometry and Gel Based Proteomic Profiling.
Stenke L; Orre L; Dhar S; Larsson R; Lewensohn R; Lehtiö J
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2005;23(16_suppl):699
Protein profiles (proteomics) discriminating between effect/no effect of weekly paclitaxel: A phase II study in metastatic breast cancer (BC)
Linderholm BK; Lehtio J; Lidbrink E; Ekman E; Karlsson P; von Wachenfeldt A; Norberg B; Carlsson L; Hatschek T; Lewensohn R
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2004;22(14_suppl):9615
Protein profiles (proteomics) discriminating between relapses versus relapse-free survival after adjuvant tamoxifen in 272 patients with primary estrogen receptor (ER) and progesterone receptor (PgR) positive breast cancer
Linderholm BK; Lehtio J; Ploner A; Pawitan Y; Skoog L; Lewensohn R
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2004;22(14_suppl):9615
Protein profiles (proteomics) discriminating between relapses versus relapse-free survival after adjuvant tamoxifen in 272 patients with primary estrogen receptor (ER) and progesterone receptor (PgR) positive breast cancer
Linderholm BK; Lehtio J; Ploner A; Pawitan Y; Skoog L; Lewensohn R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(2):484-489
The binding specificity and affinity determinants of family 1 and family 3 cellulose binding modules
Lehtiö J; Sugiyama J; Gustavsson M; Fransson L; Linder M; Teeri TT
Article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2001;67(10):4678-4684
Generation of metal-binding staphylococci through surface display of combinatorially engineered cellulose-binding domains
Wernérus H; Lehtiö J; Teeri T; Nygren P; Ståhl S
Article: PROTEIN ENGINEERING DESIGN & SELECTION. 2001;14(9):711-715
Stable linker peptides for a cellulose-binding domain-lipase fusion protein expressed in Pichia pastoris
Gustavsson M; Lehtiö J; Denman S; Teeri TT; Hult K; Martinelle M
Article: FEMS MICROBIOLOGY LETTERS. 2001;195(2):197-204
Directed immobilization of recombinant staphylococci on cotton fibers by functional display of a fungal cellulose-binding domain
Lehtiö J; Wernérus H; Samuelson P; Teeri TT; Ståhl S
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2000;41(3):316-322
Alpha-amylase inhibitors selected from a combinatorial library of a cellulose binding domain scaffold
Lehtiö J; Teeri TT; Nygren P
Article: JOURNAL OF BIOTECHNOLOGY. 1997;57(1-3):49-57
Trichoderma reesei cellobiohydrolase I with an endoglucanase cellulose-binding domain: action on bacterial microcrystalline cellulose
Srisodsuk M; Lehtio J; Linder M; MargollesClark E; Reinikainen T; Teeri TT
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Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024
Pathway activation model for personalized prediction of drug synergy
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Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024
Pathway activation model for personalized prediction of drug synergy
Trac QT; Huang Y; Erkers T; Östling P; Bohlin A; Österroos A; Vesterlund M; Jafari R; Siavelis I; Bäckvall H; Kiviluoto S; Orre LM; Rantalainen M; Lehtiö J; Lehmann S; Kallioniemi O; Pawitan Y; Vu TN
Editorial comment: CANCER DISCOVERY. 2024;14(7):1147-1153
Cancer Core Europe: Leveraging Institutional Synergies to Advance Oncology Research and Care Globally
Carmona J; Chavarria E; Donoghue K; von Gertten C; Oberrauch P; Pailler E; Scoazec G; Weijer R; Balmana J; Brana I; Brunelli C; Delaloge S; Deloger M; Delpy P; Ernberg I; Fitzgerald RC; Garralda E; Lablans M; Lehtio J; Lopez C; Fernandez M; Miceli R; Nuciforo P; Perez-Lopez R; Provenzano E; Schmidt MK; Serrano C; Steeghs N; Tamborero D; Wirta V; Baird RD; Barker K; Barlesi F; Baumann M; Bergh J; de Braud F; Fizazi K; Frohling S; Piris-Gimenez A; Seamon K; van der Heijden MS; Zwart W; Tabernero J
Preprint: BIORXIV. 2024
Pathway activation model for personalized prediction of drug synergy
Trac QT; Huang Y; Erkers T; Östling P; Bohlin A; Österroos A; Vesterlund M; Jafari R; Siavelis I; Bäckvall H; Kiviluoto S; Orre LM; Rantalainen M; Lehtiö J; Lehmann S; Kallioniemi O; Pawitan Y; Vu TN
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Multiomic profiling reveals predictive molecular characteristics of response to neoadjuvant antibody-drug conjugate versus chemotherapy and dual HER2 blockade in HER2 positive breast cancer
Foukakis T; Wang K; Zerdes I; Zhu Y; Sifakis E; Tsiknakis N; Manikis G; Salgkamis D; Harbers L; Bergh J; Johansson H; Crosetto N; Lehtio J; Matikas A; Hatschek T
Review: JOURNAL OF INTERNAL MEDICINE. 2023;294(4):455-481
Precision cancer medicine: Concepts, current practice, and future developments
Edsjo A; Holmquist L; Geoerger B; Nowak F; Gomon G; Alix-Panabieres C; Ploeger C; Lassen U; Le Tourneau C; Lehtio J; Ott PA; von Deimling A; Froehling S; Voest E; Klauschen F; Dienstmann R; Alshibany A; Siu LL; Stenzinger A
Preprint: RESEARCH SQUARE. 2023
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Erkers T; Struyf N; Arnroth C; Vesterlund M; James T; Sunandar S; Bohlin A; Hamberg-Levedahl K; Bengtzén S; Jafari R; Orre L; Lehtiö J; Lehmann S; Ostling P; Kallioniemi O; Seashore-Ludlow B
Conference publication: MOLECULAR THERAPY. 2023;31(4):667-668
Development of Oncolytic Adenovirus-Based Vaccine for Personalized Treatment of Malignant Mesothelioma
Chiaro J; Antignani G; Feola S; Feodoroff M; Martins B; Cojoc H; Ferrari V; Ciampi D; Ilonen I; Rasanen J; Mayranpaa M; Partanen J; Koskela S; Kuryk L; Russo S; Fusciello M; Hamdan F; Rescigno M; Gronholm M; Branca R; Lehtio J; Cerullo V
Conference publication: MOLECULAR THERAPY. 2023;31(4):658-659
Development of Patient-Derived 3D Tumor Organoids Combined with Immune Cells, as Preclinical Testing Platform for Personalized Cancer Immunotherapy
Antignani G; Feola S; Ferrari V; Ciampi D; Chiaro J; Feodoroff M; Fusciello M; Russo S; Hissaoui FH; Molsa R; Haapala M; Gronholm M; Branca RM; Rescigno M; Sikanen T; Lehtio J; Cerullo V
Conference publication: MOLECULAR THERAPY. 2023;31(4):454-455
Omics Integration for Enhanced Peptide Discovery for Cancer Immunotherapy
Russo S; Fusciello M; Feola S; Chiaro J; Antignani G; Feodoroff MJ; Hamdan F; Molsa R; Gronholm M; Dufva O; Mustjoki S; Branca RM; Lehtio J; Del Giudice G; Federico A; Greco D; Cerullo V
Doctoral thesis: 2022
Cancer proteogenomics : connecting genotype to molecular phenotype
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Conference publication: BLOOD. 2022;140:6299
Data-Driven Molecular Hallmarks of Acute Myeloid Leukemia: Biological, Prognostic and Therapeutic Implications
Erkers T; Marabita F; Struyf N; Vesterlund M; James T; Arnroth C; Bohlin A; Bengtzen S; Osterroos A; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
Preprint: RESEARCH SQUARE. 2022
Development of mesothelioma-specific oncolytic vaccine exploiting immunopeptidomic analysis of murine and human tumors
Chiaro J; Antignani G; Feola S; Feodoroff M; Martins B; Cojoc H; Ferrari V; Ciampi D; Ilonen I; Räsänen J; Mäyränpää M; Partanen J; Koskela S; Kuryk L; Russo S; Fusciello M; Hamdan F; Rescigno M; Grönholm M; Branca RM; Lehtiö J; Cerullo V
Conference publication: ANNALS OF ONCOLOGY. 2022;33(7):S950
Improved proteome coverage for cancer plasma-derived extracellular vesicles (pEVs) using high-resolution isoelectric focusing (HiRIEF) LC-MS
Sharma N; Mermelekas G; Lehtio J; Wiklander OPB; Gorgens A; Andaloussi S; Pernemalm M; Eriksson H
Preprint: BIORXIV. 2022
Integrative multi-omics analysis reveals molecular subtypes and tumor evolution of synovial sarcoma
Chen Y; Su Y; Leo IR; Siavelis I; Zeng J; Cao X; Tsagkozis P; Hesla A; Papakonstantinou A; Liu X; Huang W-K; Ehnman M; Johansson H; Lin Y; Lehtiö J; Zhang Y; Larsson O; Haglund de Flon F
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33:S125
Longitudinal proteogenomic profiling reveals therapeutic vulnerabilities of immunometabolism in breast cancer
Wang K; Zerdes I; Sifakis EG; Johansson HJ; Mezheyeuski A; Lehtio J; Bergh J; Hatschek T; Matikas A; Foukakis T
Corrigendum: NATURE CANCER. 2022;3(5):649
The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology (vol 3, pg 251, 2022)
Tamborero D; Dienstmann R; Rachid MH; Boekel J; Lopez-Fernandez A; Jonsson M; Razzak A; Brana I; De Petris L; Yachnin J; Baird RD; Loriot Y; Massard C; Martin-Romano P; Opdam F; Schlenk RF; Vernieri C; Masucci M; Villalobos X; Chavarria E; Balmana J; Apolone G; Caldas C; Bergh J; Ernberg I; Frohling S; Garralda E; Karlsson C; Tabernero J; Voest E; Rodon J; Lehtio J
Preprint: BIORXIV. 2022
Proteogenomics refines the molecular classification of chronic lymphocytic leukemia
Herbst SA; Vesterlund M; Helmboldt AJ; Jafari R; Siavelis I; Stahl M; Schitter EC; Liebers N; Brinkmann BJ; Czernilofsky F; Roider T; Bruch P-M; Iskar M; Kittai A; Huang Y; Lu J; Richter S; Mermelekas G; Umer HM; Knoll M; Kolb C; Lenze A; Cao X; Österholm C; Wahnschaffe L; Herling C; Scheinost S; Ganzinger M; Mansouri L; Kriegsmann K; Kriegsmann M; Anders S; Zapatka M; Del Poeta G; Zucchetto A; Bomben R; Gattei V; Dreger P; Woyach J; Herling M; Müller-Tidow C; Rosenquist R; Stilgenbauer S; Zenz T; Huber W; Tausch E; Lehtiö J; Dietrich S
Preprint: BIORXIV. 2022
Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures
Babačić H; Galardi S; Umer HM; Cardinali D; Pellegatta S; Hellström M; Uhrbom L; Maturi N; Michienzi A; Trevisi G; Mangiola A; Lehtiö J; Ciafrè SA; Pernemalm M
Preprint: RESEARCH SQUARE. 2021
Mass spectrometry-based proteomic analysis of NSCLC tumor and biopsy samples
Lehtiö J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer H; Mermelekas G; Pirmoradian M; Jönsson M; Brunnström H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevska M; Hanson CG; Haakensen VD; Helland Å; Tamborero D; Johansson H; Branca R; Planck M; Staaf J; Orre L
Preprint: RESEARCH SQUARE. 2021
STK11 pathway in vitro validation
Lehtiö J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer H; Mermelekas G; Pirmoradian M; Jönsson M; Brunnström H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevska M; Hanson CG; Haakensen VD; Helland Å; Tamborero D; Johansson H; Branca R; Staaf J; Orre L
Preprint: RESEARCH SQUARE. 2021
Immune landscape evaluation of NSCLC clinical samples
Lehtiö J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer H; Mermelekas G; Pirmoradian M; Jönsson M; Brunnström H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevska M; Hanson CG; Haakensen VD; Helland Å; Tamborero D; Johansson H; Branca R; Planck M; Staaf J; Orre L
Preprint: RESEARCH SQUARE. 2021
Bioinformatics analysis of NSCLC multi-omics data
Lehtiö J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer H; Mermelekas G; Pirmoradian M; Jönsson M; Brunnström H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevska M; Hanson CG; Haakensen VD; Helland Å; Tamborero D; Johansson H; Branca R; Planck M; Staaf J; Orre L
Preprint: BIORXIV. 2021
Generation of ENSEMBL-based proteogenomics databases boosts the identification of non-canonical peptides
Umer H; Zhu Y; Pfeuffer J; Sachsenberg T; Lehtiö J; Branca R; Perez-Riverol Y
Preprint: BIORXIV. 2021
A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines
Feola S; Chiaro J; Martins B; Russo S; Fusciello M; Ylösmäki E; Hamdan F; Feodoroff M; Antignani G; Viitala T; Pesonen S; Grönholm M; Branca R; Lehtiö J; Cerullo V
Preprint: RESEARCH SQUARE. 2021
Multi-omics molecular phenotyping of childhood acute lymphoblastic leukemia cell lines reveals novel drug vulnerabilities
Stahl M; Aswad L; Leo I; Kunold E; Post F; Erkers T; Struyf N; Mermelekas G; Joshi R; Gracia-Villacampa E; Östling P; Kalloniemi O; Tamm KP; Siavelis I; Lehtiö J; Vesterlund M; Jafari R
Preprint: RESEARCH SQUARE. 2021
Implementation of a Clinical Decision Support System for Precision Oncology across an Academic Network
Tamborero D; Dienstmann R; Rachid M; Boekel J; Lopez-Fernandez A; Braña I; De Petris L; Yachnin J; Baird R; Massard C; Opdam F; Schlenk R; Vernieri C; Masucci M; Villalobos X; Chavarria E; Balmaña J; Apolone G; Caldas C; Bergh J; Ernberg I; Fröhling S; Garralda E; Karlsson C; Tabernero J; Voest E; Rodon J; Lehtiö J
Preprint: RESEARCH SQUARE. 2021
PeptiCHIP: a novel microfluidic-based chip platform for tumour antigen landscape identification
Feola S; Haapala M; Peltonen K; Capasso C; Martins B; Antignani G; Federico A; Pietiäinen V; Chiaro J; Feodoroff M; Rannikko A; Fusciello M; Koskela S; Partanen J; Hamdan F; Tähkä S; Ylösmäki E; Greco D; Grönholm M; Kekarainen T; Eshaghi M; Gurvich O; Ylä-Herttuala S; Branca RM; Lehtiö J; Sikanen T; Cerullo V
Conference publication: HUMAN GENE THERAPY. 2021;32(19-20):A89
A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines
Feola S; Chiaro J; Martins B; Russo S; Fusciello M; Ylosmaki E; Hamdan F; Feodoroff M; Antignani G; Viitala T; Pesonen S; Gronholm M; Branca RMM; Lehtio J; Cerullo V
Conference publication: HUMAN GENE THERAPY. 2021;32(19-20):A89
A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines
Feola S; Chiaro J; Martins B; Russo S; Fusciello M; Ylosmaki E; Hamdan F; Feodoroff M; Antignani G; Viitala T; Pesonen S; Gronholm M; Branca RMM; Lehtio J; Cerullo V
Conference publication: CANCER RESEARCH. 2021;81(13)
PeptiCHIP: A novel microfluidic-based chip platform for tumor antigen landscape identification.
Feola S; Happala M; Peltonen K; Capasso C; Antignani G; Federico A; Pietiainen V; Chiaro J; Feodoroff M; Ranniko A; Fusciello M; Koskela S; Partanen J; Hamdan F; Tahka S; Ylosmaki E; Greco D; Gronholm M; Branca RMM; Lehtio J; Siikanen T; Cerullo V
Conference publication: MOLECULAR THERAPY. 2021;29(4):330
PeptiCHIP: A Novel Microfluidic-Based Chip Platform for Tumour Antigen Landscape Identification
Feola S; Haapala M; Peltonen K; Capasso C; Martins B; Antignani G; Federico A; Pietiainen V; Chiaro J; Feodoroff M; Ranniko A; Fusciello M; Koskela S; Partanen J; Hamdan F; Tahka S; Ylosmaki E; Greco D; Gronholm M; Kekarainen T; Eshaghi M; Gurvich OL; Yla-Herttuala S; Branca RMM; Lehtio J; Sikanen T; Cerullo V
Conference publication: MOLECULAR THERAPY. 2021;29(4):306
Establishment of an Innovative Immunopeptidomic Based Pipeline for the Generation of Oncolytic Cancer Vaccines
Feola S; Martins B; Chiaro J; Russo S; Fusciello M; Ylosmaki E; Antignani G; Hamdan F; Feodoroff M; Gronholm M; Branca RMM; Lehtio J; Cerullo V
Meeting abstract: ANNALS OF ONCOLOGY. 2020;31:S760
Plasma proteomics in patients with metastatic cutaneous melanoma treated with targeted therapy
Eriksson H; Babacic H; Lehtio J; Pernemalm M
Conference publication: CANCER RESEARCH. 2020;80(16):2371
FBXL12 modulates Fanconi anaemia-BRCA signaling under conditions of oncogene-induced replication stress
Brunner A; Johansson H; Kourtesakis A; Rantala J; Spruck C; Wohlschlegel J; Lehtio J; Sangfelt O
Letter: NATURE MEDICINE. 2020;26(7):992-994
Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal
Tamborero D; Dienstmann R; Rachid MH; Boekel J; Baird R; Brana I; De Petris L; Yachnin J; Massard C; Opdam FL; Schlenk R; Vernieri C; Garralda E; Masucci M; Villalobos X; Chavarria E; Calvo F; Frohling S; Eggermont A; Apolone G; Voest EE; Caldas C; Tabernero J; Ernberg I; Rodon J; Lehtio J
Preprint: MEDRXIV. 2020
Global between-countries variance in SARS-CoV-2 mortality is driven by reported prevalence, age distribution, and case detection rate
Babačić H; Lehtiö J; Pernemalm M
Meeting abstract: BLOOD. 2019;134:4641
High-Throughput Functional Ex-Vivo Drug Testing and Multi-Omics Profiling in Patients with Acute Myeloid Leukemia
Erkers T; Seashore-Ludlow B; Struyf N; Marabita F; James T; Malani D; Vesterlund M; Stalhl M; Pawitan Y; Lehmann S; Ostling P; Lehtio J; Kallioniemi O
Corrigendum: SCIENTIFIC REPORTS. 2019;9(1):15014
Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin (vol 8, 9182, 2018)
Johansson HJ; Vallhov H; Holm T; Gehrmann U; Andersson A; Johansson C; Blom H; Carroni M; Lehtio J; Scheynius A
Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(15):9574
Plasma proteomic analyses and treatment predictive biomarker candidates in melanoma patients receiving immune checkpoint blockade or targeted therapy.
Eriksson H; Babacic H; Lehtio J; Pernemalm M
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2019;18(8):S30
Cancer proteomics - connecting genotype with molecular phenotype
Lehtio J
Conference publication: ANNALS OF ONCOLOGY. 2019;30:536
Plasma proteomics in patients with metastatic cutaneous melanoma treated with immune checkpoint inhibitors
Eriksson H; Babic H; Lehtio J; Pernemalm M
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2019;18(8):S61
Production and Generation of Proteogenomics Databases using PyPGATK
Umer HM; Zhu Y; Audain E; Lehtio J; Branca R; Perez-Riverol Y
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2019;18(8):S40
Breast cancer quantitative proteome and proteogenomic landscape
Johansson HJ; Socciarelli F; Vacanti NM; Haugen MH; Zhu Y; Siavelis I; Fernandez-Woodbridge A; Aure MR; Sennblad B; Vesterlund M; Branca RM; Orre LM; Huss M; Fredlund E; Beraki E; Garred O; Boeke J; Sauer T; Zhao W; Nord S; Hoglander EK; Jans DC; Brismar H; Haukaas TH; Bathen TF; Schlichting E; Naume B; Luders T; Borgen E; Kristensen VN; Russnes HG; Lingjaerde OC; Mills GB; Sahlberg KK; Borresen-Dale A-L; Lehtio J
Corrigendum: NATURE COMMUNICATIONS. 2018;9(1):1852
Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow (vol 9, 2018)
Zhu Y; Orre LM; Johansson HJ; Huss M; Boekel J; Vesterlund M; Fernandez-Woodbridge A; Branca RMM; Lehtio J
Preprint: BIORXIV. 2018
The Viral Protein Corona Directs Viral Pathogenesis and Amyloid Aggregation
Ezzat K; Pernemalm M; Pålsson S; Roberts T; Järver P; Dondalska A; Bestas B; Sobkowiak M; Levänen B; Sköld M; Thompson E; Saher O; Kari O; Lajunen T; Ekström ES; Nilsson C; Ishchenko Y; Malm T; Wood MJA; Power U; Masich S; Lindén A; Sandberg J; Lehtiö J; Spetz A-L; Andaloussi SEL
Conference publication: QUALITY OF LIFE RESEARCH. 2018;27:S2-S3
Analysis of early predictive lung cancer symptoms and sensations by orthogonal projections to latent structures (OPLS)
Levitsky A; Pernemalm M; Runesdotter S; Bernhardson B-M; Forshed J; Lehtio J; Tishelman C; Eriksson LE
Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2018;47:2
Systemic lupus erythematosus subgroups, with features of antiphospholipid or Sjogren's syndrome, differ in molecular signatures and treatment perspectives
Idborg H; Zandian A; Sandberg A; Truedsson L; Nilsson B; Elvin K; Mo J; Gustafsson J; Gunnarsson I; Lehtio J; Nilsson P; Svenungsson E; Jakobsson P
Preprint: BIORXIV. 2017
Strong binding activity of few transcription factors is a major determinant of open chromatin
Wei B; Jolma A; Sahu B; Orre LM; Zhong F; Zhu F; Kivioja T; Sur IK; Lehtiö J; Taipale M; Taipale J
Preprint: BIORXIV. 2017
Utilizing a resource of enrichment profiles in plasma for the systematic assessment of antibody selectivity
Fredolini C; Byström S; Sanchez-Rivera L; Ioannou M; Tamburro D; Branca R; Nilsson P; Lehtiö J; Schwenk J
Review: ENVIRONMENTAL MICROBIOLOGY. 2017;19(6):2301-2319
Comparative proteomics reveals signature metabolisms of exponentially growing and stationary phase marine bacteria
Muthusamy S; Lundin D; Branca RMM; Baltar F; Gonzalez JM; Lehtio J; Pinhassi J
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):253
The role of extracellular vesicles (MalaEx) from the commensal yeast Malassezia sympodialis in atopic eczema
Vallhov H; Johansson H; Holm T; Gehrmann U; Johansson C; Andersson A; Lehtio J; Scheynius A
Conference publication: PEDIATRIC BLOOD & CANCER. 2017;64:S224-S225
MYCN Mediates Metabolic Reprogramming in Childhood Neuroblastoma
Henriksson MA; Oliynyk G; Perez MVR; Dzieran J; Zirath H; Johassson H; Lehtio J
Conference publication: CELL TRANSPLANTATION. 2017;26(4):704
Mesenchymal Stem Cell-Derived Exosomes Mediate Neurovascular Protection
Anderson JD; Rossignol J; Dunbar GL; Yavagal D; EL-Andaloussi S; Lehtio J; Nolta JA
Conference publication: CELL TRANSPLANTATION. 2017;26:704
Mesenchymal Stem Cell-Derived Exosomes Mediate Neurovascular Protection
Anderson JD; Rossignol J; Dunbar GL; Yavagal D; EL-Andaloussi S; Lehtio J; Nolta JA
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):290
Modulation of innate immune responses by extracellular single stranded oligonucleotides
Jarver P; Dondalska A; Skold A; Sandberg A; Zaghloul E; Brodin D; Poux C; Lehtio J; Lennox K; Behlke M; Le Grand R; El-Andaloussi S; Spetz A-L
Conference publication: NEUROMUSCULAR DISORDERS. 2017;27:S5-S6
Age-related and mutation-independent proteomic changes in dystrophic mouse muscle
van Westering TLE; Johansson HJ; Coenen-Stass AML; Tanihata J; Takeda S; Yokota T; Lehtio J; Wood MJA; El Andaloussi S; Roberts TC; Aoki Y
Meeting abstract: CANCER RESEARCH. 2016;76:2385
Understanding the dynamic interplay between genetically different cancer cell clones in glioblastoma
Guo M; Heller S; Thorslund J; Orre L; Lehtio J; Nister M; Hagerstrand D
Conference publication: CANCER RESEARCH. 2016;76:3881
Breast cancer proteogenomics landscape defines subtype specific protein level regulations and reveals proteins coded by pseudogenic loci
Johansson H; Zhu Y; Haugland M; Sahlberg K; Fredlund E; Huss M; Vacanti N; Aure MR; Sennblad B; Kjellqvist S; Orre L; Lingjaerde OC; Borresen-Dale A-L; Lehtio J
Corrigendum: STEM CELLS TRANSLATIONAL MEDICINE. 2016;5(6):845
In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome (vol 4, pg 1199, 2015)
Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalen M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Hagglund H; Mattsson M; Lehtio J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Preprint: PEERJ PREPRINTS. 2016
Comparative proteomics reveals signature metabolisms of exponentially growing and stationary phase marine bacteria
Muthusamy S; Lundin D; Branca RM; Baltar F; González JM; Lehtiö J; Pinhassi J
Preprint: PEERJ PREPRINTS. 2016
Comparative proteomics reveals signature metabolisms of exponentially growing and stationary phase marine bacteria
Muthusamy S; Lundin D; Branca RMM; Baltar F; González J; Lehtiö J; Pinhassi J
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2016;83(5):353
Integrative molecular profiling during human induced regulatory T cell (iTreg) generation reveals novel regulators of FOXP3
Schmidt A; Marabita F; Johansson H; Lehtio J; Eriksson M; Elias S; Gomez-Cabrero D; Rao A; Tegner J
Conference publication: CELL TRANSPLANTATION. 2016;25(4):750
Proteomic and Therapeutic Profile of Mesenchymal Stem Cell Exosomes in Neurological-Related Diseases
Anderson JD; Rossignol J; Lein P; EL-Andaloussi S; Lehtio J; Nolta JA
Conference publication: CANCER RESEARCH. 2015;75:3462
Proteomic profiling reveals novel targets for combination treatment with lanreotide in neuroendocrine tumors
Fotouhi O; Kjellin H; Hashemi J; Lu M; Juhlin C; Hoog A; Zedenius J; Larsson C; Lehtio J; Kjellman M
Letter: NATURE BIOTECHNOLOGY. 2015;33(2):137-139
Multi-omic data analysis using Galaxy
Boekel J; Chilton JM; Cooke IR; Horvatovich PL; Jagtap PD; Kall L; Lehtio J; Lukasse P; Moerland PD; Griffin TJ
Conference publication: PEDIATRIC BLOOD & CANCER. 2015;62:S179-S180
MYC AND MITOCHONDRIAL METABOLISM IN CHILDHOOD NEUROBLASTOMA
Henriksson MA; Oliynyk G; Zirath H; Johansson H; Lehtio J
Conference publication: 2014;:99-106
Optimizing Analytical Depth and Cost Efficiency of IEF-LC/MS Proteomics
Kifer I; Ben-Dar A; Yakhini Z; Branca RM; Lehtiö J; Xu P
Review: EXPERT REVIEW OF PROTEOMICS. 2014;11(4):431-448
Mass spectrometry-based plasma proteomics: state of the art and future outlook
Pernemalm M; Lehtio J
Conference publication: ENDOCRINE REVIEWS. 2014;35(3)
Molecular Differences Between Oxyphilic Cell and Chief Cell Parathyroid Adenoma
Lu M; Kjellin H; Fotouhi O; Lee L; Nilsson I-L; Hoog A; Lehtio J; Larsson C
Conference publication: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2014;19:S770
Structure, function and assembly of an oxygen-activating heterodinuclear Mn/Fe cofactor
Griese JJ; Roos K; Cox N; Shafaat HS; Branca RMM; Lehtio J; Graslund A; Lubitz W; Siegbahn PEM; Hogbom M
Conference publication: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2014;19:S278
Assembly of an oxygen-activating heterodinuclear manganese/iron cofactor
Griese JJ; Graslund A; Hogbom M; Roos K; Siegbahn PE; Cox N; Shafaat HS; Lubitz W; Branca RM; Lehtio J
Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2014;43:95
Proteomics and metabolomics in the classification of SLE subsets
Jakobsson P-J; Svenungsson E; Idborg H; Nilsson P; Wheelock C; Gunnarsson I; Trygg J; Lehtio J; Koistinen IS
Conference publication: CANCER RESEARCH. 2013;73(8):833
S100A4 interacts with p53 in the nucleus promoting its degradation.
Orre L; Panizza E; Kaminskyy V; Graslund T; Zhivotovsky B; Lehtio J
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:A80
STRATIFICATION OF SLE PATIENTS FOR IMPROVED DIAGNOSIS AND TREATMENT
Idborg H; Rannar S; Oliynyk G; Forshed J; Branca RM; Donten M; Bennett K; Gustafsson J; Vikerfors A; Truedsson L; Nilsson B; Gunnarsson I; Trygg J; Lehtio J; Lundstedt T; Svenungsson E; Jakobsson P-J
Conference publication: ANGIOGENESIS. 2013;16(1):271-272
Mechanistic studies on pericyte regulated functions at the neurovascular unit
Mae AM; Raschperger E; Keller A; Johansson H; Lavina-Siemsen B; Hofmann J; Olsson C; Lehtio J; Betsholtz C
Conference publication: ANGIOGENESIS. 2013;16(1):270-271
Mechanistic studies on pericyte regulated functions at the neurovascular unit
Mae AM; Keller A; Raschperger E; Johansson H; Lavina-Siemsen B; Hofmann J; Lehtio J; Betsholtz C
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:466
STRATIFICATION OF SLE PATIENTS FOR IMPROVED DIAGNOSIS AND TREATMENT
Idborg H; Rannar S; Oliynyk G; Forshed J; Branca RM; Donten M; Bennett K; Gustafsson J; Vikerfors A; Elvin K; Truedsson L; Nilsson B; Gunnarsson I; Trygg J; Lehtio J; Lundstedt T; Svenungsson E; Jakobsson P-J
Review: FEBS JOURNAL. 2012;279(21):4062-4080
Tumour suppressor p16INK4a-anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model
Amano M; Eriksson H; Manning JC; Detjen KM; Andre S; Nishimura S-I; Lehtio J; Gabius H-J
Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2012;48:43
Unraveling BRAF Inhibitor (PLX4032) Resistance Mechanisms
Azimi A; Johansson CH; Pernemalm M; Touminen R; Lehtio J; Hansson J; Egyhazi S
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:532
SYSTEMS BIOLOGY OF SLE: BIOCHEMICAL CHARACTERIZATION OF SUBGROUPS WITHIN SLE FOR IMPROVED DIAGNOSIS AND TREATMENT
Idborg H; Oliynyk G; Rannar S; Forshed J; Branca RM; Donten M; Gustafsson J; Vikerfors A; Gunnarsson I; Trygg J; Lehtio J; Lundstedt T; Svenungsson E; Jakobsson P-J
Conference publication: ANNALS OF ONCOLOGY. 2012;23:v27
P2.17 Proteomics and Gene Expression Profiling of Melanoma Chemotherapy Response in Tumors
Johansson CH; Azimi A; Pernemalm M; Pawitan Y; Stolt MF; Lazar V; Lundeberg J; Lehtiö J; Egyhazi S; Hansson J
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a12
SYSTEMS BIOLOGY OF SLE: BIOCHEMICAL CHARACTERISATION OF SUBGROUPS WITHIN SLE FOR IMPROVED DIAGNOSIS AND TREATMENT
Idborg H; Oliynyk G; Rannar S; Forshed J; Branca RM; Donten M; Gustafsson J; Vikerfors A; Gunnarsson I; Trygg J; Lehtio J; Lundstedt T; Svenungsson E; Jakobsson P-J
Conference publication: DIABETOLOGIA. 2012;55:S217
A proteomic investigation of the response induced by palmitate and thapsigargin in the insulin producing cell line INS-1E
Rosengren V; Johansson H; Lehtio J; Sjoholm A; Ortsater H
Conference publication: ANNALS OF ONCOLOGY. 2012;23:33-34
GENOME WIDE PROTEOMICS USING PEPTIDE HIGH RESOLUTION ISOELECTRIC FOCUSING HIRIEF-MS ALLOWS DETECTION NEW HUMAN GENE MODELS
Lehtio J; Branca M; Johansson H; Orre M; Granholm V; Forshed J; Perez-Bercoff M; Kall L
Conference publication: ANNALS OF ONCOLOGY. 2012;23:38
PROTEOMICS ANCHORED SYSTEMS BIOLOGY ANALYSIS OF PROGNOSTIC FACTORS IN PRIMARY LUNG ADENOCARCINOMA TUMOURS
Pernemalm A; Branca M; Petris DE; Forshed J; Lewensohn R; Besse B; Lazar V; Van den Oord J; Pawitan Y; Lehtio J
Conference publication: ANNALS OF ONCOLOGY. 2012;23:27
PROTEOMICS AND GENE EXPRESSION PROFILING OF MELANOMA CHEMOTHERAPY RESPONSE IN TUMORS
Johansson CH; Azimi A; Pernemalm M; Pawitan Y; Stolt MF; Lazar V; Lundeberg J; Lehtio J; Egyhazi S; Hansson J
Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2011;47:S124
Plasma Metabolomics in Non-small-cell Lung Cancer
De Petris L; Forshed J; Antti H; Branden E; Koyi H; Johnsson A; Lewensohn R; Lehtio J
Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2011;47:S78
Cancer Proteomics - From low Resolution to High Resolution to Study Lung Cancer Phenotype
Lehtio J; De Petris L; Pernemalm M; Forshed J; Branca R; Orre LM
Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2011;29(15):628
Proteomics-based characterization of potential biomarkers in tamoxifen resistance in breast cancer.
Sanchez BC; Johansson H; Forshed J; Stal O; Lehtio J; Linderholm BK
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183:a6404
High Sensitivity Approach For Identification Of MHC Class II-Bound Peptides From Bronchoalveolar Lavage Cells In Sarcoidosis Patients
Kasuga K; Branca RM; Wahlstrom J; Wheelock AM; Eklund A; Grunewald J; Lehtio J
Meeting abstract: BREAST. 2011;20:S25
Identification and characterization of proteomic changes associated to tamoxifen-resistance in breast cancer cells
Sanchez BC; Johansson H; Lehtio J; Linderholm BK
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2011;6(6):S965-S966
CLINICAL IMPLICATIONS OF THE TUMOR EXPRESSION OF S100 PROTEINS IN NON-SMALL-CELL LUNG CANCER
De Petris L; Kanter L; Melotti F; Bergman P; Kolbeck K-G; Hellborg H; Adolfsson J; Lewensohn R; Lehtio J
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2011;6(6):S1071-S1072
PROTEOMICS ANCHORED SYSTEMS BIOLOGY ANALYSIS OF PROGNOSTIC FACTORS IN PRIMARY LUNG ADENOCARCINOMA TUMOURS
Lehtio J; Pernemalm M; Lewensohn R; Van Den Oost J; Forshed J; Branca R; Alexeyenko A; De Petris L; Blackhall F; Pawitan Y; Besse B; Lazar V
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2011;6(6):S304
MICRORNAS IN LUNG CANCER A FUNCTIONAL GENOMICS APPROACH FOR DISCOVERY AND VALIDATION OF NOVEL FACTORS DETERMINING RESPONSE TO TREATMENT WITH EGFR-INHIBITORS.
Orre LM; Le Sage C; Agami R; Lehtio J
Review: JOURNAL OF PROTEOMICS. 2010;73(10):1851-1863
Lung cancer proteomics, clinical and technological considerations
Lehtio J; De Petris L
Conference publication: CANCER RESEARCH. 2010;70:4956
Proteomics-based characterization of pathways involved in tamoxifen resistance in breast cancer cells
Sanchez BC; Johansson H; Lehtio J; Stal O; Linderholm BK
Conference publication: ANNALS OF ONCOLOGY. 2010;21:41
PROTEOMICS PROFILING OF BREAST CANCER PATIENTS RECEIVING TAMOXIFEN
Johansson HJ; Sanchez BC; Bergh J; Linderholm B; Lehtio J
Review: PROTEOMICS. 2009;9(6):1420-1427
Affinity prefractionation for MS-based plasma proteomics
Pernemalm M; Lewensohn R; Lehtio J
Conference publication: CANCER RESEARCH. 2009;69
Proteomic studies in well differentiated thyroid tumors
Sofiadis A; Zedenius J; Wallin G; Foukakis T; Hoog A; Orre L; Lehtio J; Larsson C
Conference publication: DIABETOLOGIA. 2009;52:S149
Protein levels of GRP78 and protein disulfide isomerases A3 and A6 are decreased during thapsigargin treatment of INS-1E cells
Rosengren V; Johansson H; Fransson L; Lehtio J; Sjoholm A; Ortsater H
Conference publication: ANNALS OF ONCOLOGY. 2009;20:44
INVESTIGATION OF THE PROTEOMIC DIFFERENCES BETWEEN TAMOXIFEN RESPONSIVE AND RESISTANT CELL LINES BY MASS SPECTROMETRY
Johansson HJ; Sanchez BC; Lehtio J; Linderholm B
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2009;4(9):S902-S903
Potential diagnostic and prognostic role of serum levels of cytokeratin 18, in both its intact and caspase-cleaved forms, in patients with NSCLC
De Petris L; Branden E; Pernemalm M; Koyi H; Herrmann R; Lewensohn R; Linder S; Lehtio J
Conference publication: ANTICANCER RESEARCH. 2008;28(5C):3275-3276
QUANTITATIVE MEMBRANE PROTEOMICS APPLYING NARROW RANGE PEPTIDE ISOELECTRIC FOCUSING FOR STUDIES OF SMALL CELL LUNG CANCER RESISTANCE MECHANISMS
Eriksson H; Lengqvist J; Hedlund J; Uhlen K; Orre LM; Bjellqvist B; Persson B; Lehtio J; Jakobsson P-J
Conference publication: ANNALS OF ONCOLOGY. 2008;19:50-51
IN DEPTH PROTEOMICS PROFILING OF PLASMA AND PLEURAL EFFUSION FOR DETECTION OF DIAGNOSTIC BIOMARKERS OF LUNG ADENOCARCINOMA
Pernemalm M; De Petris L; Branden E; Koyi H; Lewensohn R; Lehtioe J
Conference publication: ANTICANCER RESEARCH. 2008;28(5C):3430-3431
FUNCTIONAL STUDIES OF S100A6 USING PROTEOMICS
Orre LM; Vernet E; Lengvist J; Graslund T; Lewensohn R; Lehtio J
Conference publication: ANTICANCER RESEARCH. 2008;28(5C):3497
PROTEOMICS AND PATHWAY ANALYSIS IDENTIFIES JNK-SIGNALING AS CRITICAL FOR HIGH-LET RADIATION-INDUCED APOPTOSIS IN NON-SMALL LUNG CANCER CELLS
Stahl S; Fung E; Adams C; Lengqvist J; Mork B; Stenerlow B; Lewensohn R; Lehtio J; Zubarev R; Viktorsson K
Review: PROTEOMICS CLINICAL APPLICATIONS. 2007;1(9):1058-1065
Proteomics in clinical prostate research
Hellstrom M; Jonmarker S; Lehtio J; Auer G; Egevad L
Meeting abstract: JOURNAL OF THORACIC ONCOLOGY. 2007;2(8):S356-S357
Mass spectrometry profiling of low molecular weight platelet Proteome for the detection of lung cancer specific biomarkers
De Petris L; Pernemalm M; Branden E; Koyi H; Forshed J; Sundelin B; Lewensohn R; Lehtio J
Published conference paper: PROTEOMICS. 2007;7(11):1746-1752
iTRAQ compatibility of peptide immobilized pH gradient isoelectric focusing
Lengqvist J; Uhlen K; Lehtio J
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2006;5(10):S278
Proteomic profiling of blast cells from patients with acute myeloid leukaemia, retrospective study
Pernemalm M; Forshed J; Stenke L; Lewensohn R; Kanter L; Lehtio J
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2006;5(10):S190
Assessment of two quantitative methods for analyzing the membrane proteome of human adrenal tumor tissue
Eriksson H; Lengqvist J; Lehtio J; Kjellman M; Jakobsson P-J
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2006;5(10):S232
Examination and identification of signalling components involved in cellular response to radiation by using a phosphoproteomic approach
Stahl S; Viktorsson K; Lennqvist J; Stenerlow B; Lewensohn R; Lehtio J
Conference publication: BLOOD. 2006;108(11):187B
Global proteomics in AML:: Using SELDI-TOF MS on diagnostic samples to identify spectra and protein biomarkers indicative of prognosis
Stenke L; Pememalm M; Forshed J; Pawitan Y; Lagergren-Lindberg M; Kanter L; Lehtio J
Conference publication: BLOOD. 2005;106(11):666A
Detection of proteins related to therapeutic outcome, including drug resistance, in acute myeloid leukemia using mass spectrometry and gel based proteomic profiling.
Stenke L; Orre L; Dhar S; Larsson R; Lewensohn R; Lehtiö J
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2005;23(16):52S
Protein profiles (proteomics) discriminating between effect/no effect of weekly paclitaxel: A phase II study in metastatic breast cancer (BC).
Linderholm BK; Lehtio J; Lidbrink E; Ekman E; Karlsson P; von Wachenfeldt A; Norberg B; Carlsson L; Hatschek T; Lewensohn R
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2005;4(8):S125
Cancer biomarker discovery;: a novel approach to obtain increased proteomic coverage in serum profiles using SELDI-TOF
Pernemalm M; Lehtio J; Lewensohn R; De Petris L; Koy H; Branden E; Brattstrom D
Published conference paper: LECTURE NOTES IN COMPUTER SCIENCE. 2005;3695:140-150
ProSpect:: An R package for analyzing SELDI measurements identifying protein biomarkers
Quandt A; Ploner A; Tan CS; Lehtiö J; Pawitan Y
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2005;4(8):S116
MS protein profiles discriminating between relapses versus relapse-free survival after adjuvant tamoxifen for patients with a primary ER- and PgR-positive breast cancer
Lehtio J; Linderholm B; Skoog L; Ploner A; Pawitan Y; Lewensohn R
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2005;4(8):S32
Peak detection of SELDI measurements for identifying protein biomarkers
Tan C; Ploner A; Quandt A; Lehtioe J; Pawitan Y
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2004;3(10):S35
Detection of proteins related to doxorubicin resistance in myeloma and leukemia using mass Spectrometry-based proteomic profiling
Orre L; Dhar S; Lewensohn R; Stenke L; Larsson R; Lehtioe J
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2004;22(14):863S
Protein profiles (proteamics) discriminating between relapses versus relapse-free survival after adjuvant tamoxifen in 272 patients with primary estrogen receptor (ER) and progesterone receptor (PgR) positive breast cancer.
Linderholm BK; Lehtio J; Ploner A; Pawitan Y; Skoog L; Lewensohn R
Review: JOURNAL OF BIOTECHNOLOGY. 2002;96(1):67-78
Engineering of staphylococcal surfaces for biotechnological applications
Wernérus H; Lehtiö J; Samuelson P; Ståhl S
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Forskningsbidrag

Lehtiö, Janne – Proteogenomics for improved cancer immune therapy combinations and predictive biomarkers
Swedish Cancer Society
1 January 2024
Facilitating Early Diagnosis of Lung Cancer: Transdisciplinary Efforts Combining Data from Patient-Reports, Biomarkers and Imaging
Swedish Research Council
1 January 2023 - 31 December 2025
National infrastructure to support clinical trials in precision medicine with cutting edge technologies
Swedish Research Council
1 January 2023 - 31 December 2026
Pioneering technology, so-called proteogenomics, to develop immunotherapies for children with ALL
Barncancerfonden
1 January 2022 - 31 December 2022
Subpopulation heterogeneity and microenvironmental engagement as predictors for treatment resistance in lymphoma
Swedish Research Council
1 January 2022 - 31 December 2024
Facilitating Early Diagnosis of Lung Cancer: Transdisciplinary Efforts Combining Data from Patient-Reports, Biomarkers and Imaging
Sjöbergstiftelsen
1 January 2022 - 31 December 2024
Lehtiö, Janne – Proteogenomics to support targeted cancer treatment selection
Swedish Cancer Society
1 January 2021
Precision care bringing technology innovation into oncology (PRIO)
VINNOVA
6 May 2020 - 31 January 2021
Linking the experienced and biological bodies for facilitating lung cancer diagnosis and monitoring treatment response: a biobehavioural nursing research project
Swedish Research Council
1 January 2020 - 31 December 2022
Next generation HTP-proteomics for accurate molecular phenotype analysis
Swedish Research Council
1 January 2020 - 31 December 2023
Proteogenomics for next generation cancer immunotherapy
Swedish Cancer Society
1 January 2018
Facilitating lung cancer diagnosis; linking the experienced body and the biological body
Swedish Research Council
1 January 2017 - 31 December 2019
Proteogenomics for next generation cancer immunotherapy
Swedish Cancer Society
1 January 2017
Proteogenomics methods to analyze genotype impact on the proteome
Swedish Research Council
1 January 2016 - 31 December 2019
Infrastructure for information-rich proteome analysis
Swedish Foundation for Strategic Research
1 January 2016 - 31 December 2020
Proteogenomics - Improved understanding of cancer mutations by linking gene and protein level assays
Swedish Cancer Society
1 January 2016
Proteogenomics - Improved understanding of cancer mutations by linking gene and protein level assays
Swedish Cancer Society
1 January 2015
Modulation of TLR3-mediated innate responses to dampen excessive inflammation and inhibit viral replication
Swedish Research Council
1 January 2014 - 31 December 2017
Proteogenomics - Improved understanding of cancer mutations by linking gene and protein level assays
Swedish Cancer Society
1 January 2014
Application from Johnathon D. Anderson in the Graduate Research Opportunity Worldwide program
Swedish Research Council
1 January 2013 - 31 December 2013
High Resolution peptide IsoElectric Focusing (HiRIEF), a method for in-depth quantitative proteomics
Swedish Research Council
1 January 2013 - 31 December 2015
Development of targeted and multiplexed protein quantification for pathway proteomics and efficient validation of biomarker candidates
Swedish Research Council
1 January 2010 - 31 December 2012
Discovery of novel radiotherapeutic strategies for cancer treatement using a systems biology approach
Swedish Research Council
1 January 2010 - 31 December 2012
A high resolution mass spectrometer with multiple ionization functionality for research in metabolomics and proteomics
Swedish Research Council
1 January 2009 - 31 October 2014
Mapping of prediagnostic health changes: linking subjective experience with clinical, metabolic, and molecular changes to facilitate early detection of lung cancer
Swedish Research Council
1 January 2009 - 31 December 2011
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