Janne Lehtiö
Professor/Clinical Chemist | Docent
E-mail: janne.lehtio@ki.se
Telephone: +46852481416
Visiting address: SciLifeLab, Tomtebodavägen 23A, 17121 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Lehtiö, 171 77 Stockholm
About me
- Professor Janne Lehtiö and the LehtiöLab focuses on proteomics and proteogenomics to gain new knowledge on molecular phenotype of cancer and use that information to improve personalized medicine. Lehtiö has since 2008 been principle investigator at Dept. of Oncology and Pathology at Karolinska Institutet (KI), Sweden, leading the cancer proteomics research group of 25 researchers.
At 2004, Dr. Lehtiö was appointed as director of the Karolinska University Hospital’s clinical proteomics facility and since 2010 he is director of the clinical proteomics mass spectrometry facility at the national research center Science for Life Laboratory t Stockholm. He received a faculty professor position in Medical Proteomics at Karolinska Institutet in 2015 and since 2021 has shared clinical appointment at Karolinska University Hospital as head of clinical proteomics unit. Previously, he completed his MSc on biochemistry in Helsinki University, Finland and PhD in engineering in Royal Institute of Technology in Stockholm, Sweden.
Education
I achieved MSc degree in biochemistry from Helsinki University, Finland and PhD in engineering (biotechnology) at Royal Institute of Technology (KTH) in Stockholm, Sweden. Post the PhD, I worked few years in biotech industry in USA and Europe - and obtained postdoctoral experience in cancer research at Karolinska Institutet, Stockholm, Sweden. In 2009, I got an assistant professor in proteomics (docent) merit at Karolinska Institutet and was pointed to the faculty Professor position 2015. Since 2006, I have also been director of the Karolinska University Hospital’s clinical proteomics facility and since 2021 holds share position at pathology clinic as hospital chemist.
Academic awards and honors
2015 Research infrastructure fellow, Swedish Foundation for Strategic Research
2015 The Swedish Mass Spectrometry Society medal in the honor of Jöns Jacob Berzelius
2009 Thought Leadership Award, Agilent Foundation, USA.
Research
- Our major research interest is to improve proteomics and proteogenomics to obtain new molecular information on cancer and use this information to improve and personalize future cancer treatments. Proteomics research aims to study thousands of proteins simultaneously in a sample to obtain a molecular picture of the ongoing biology. In cancer, this proteome wide analysis provides data on how certain genotype and environmental factors combined can drive tumour growth. We thrive to use this knowledge to improve cancer therapy by discovering new biomarkers and therapy targets. Lehtiö’s group has published number of novel methods for proteome analysis and omics data-analysis. The main focus on our clinical proteomics and system biology research is on lung and breast cancer fields as well as on a newly started program on childhood cancers and leukemia. We work also for clinical implementation of omics data via our Molecular Tumor board portal.
Teaching
- Our group organizes several courses on proteomics and multi-omics data analysis as well as cources on precision medicine each year. For more information check KI and SciLifeLabs cource program.
Articles
- Article: JOURNAL OF INTERNAL MEDICINE. 2024;295(6):785-803
- Article: BLOOD. 2024;143(19):1953-1964
- Article: NPJ PRECISION ONCOLOGY. 2024;8(1):38
- Article: SCIENCE ADVANCES. 2023;9(48):eadg8014
- Article: NATURE COMMUNICATIONS. 2023;14(1):7056
- Article: MOLECULAR CELL. 2023;83(20):3720-3739.e8
- Article: NATURE COMMUNICATIONS. 2023;14(1):5921
- Article: NPJ PRECISION ONCOLOGY. 2023;7(1):32
- Article: LEUKEMIA. 2023;37(3):550-559
- Article: MOLECULAR ONCOLOGY. 2023;17(2):238-260
- Article: NATURE COMMUNICATIONS. 2022;13(1):6226
- Article: NATURE PROTOCOLS. 2022;17(8):1832-1867
- Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(6):434-446
- Article: NATURE COMMUNICATIONS. 2022;13(1):1691
- Article: ELIFE. 2022;11:e71156
- Article: BIOINFORMATICS. 2022;38(5):1470-1472
- Article: NATURE CANCER. 2022;3(2):251-261
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(45):e2100050118
- Article: NATURE CANCER. 2021;2(11):1224-1242
- Article: ACS NANO. 2021;15(10):15992-16010
- Article: CANCERS. 2021;13(14):3408
- Article: METABOLITES. 2021;11(5):310
- Article: AMERICAN JOURNAL OF HEMATOLOGY. 2021;96(5):580-588
- Article: NATURE REVIEWS METHODS PRIMERS. 2021;1(1):32
- Article: VIRUSES. 2020;12(12):E1423-1423
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(12):2047-2068
- Article: NEOPLASIA: AN INTERNATIONAL JOURNAL FOR ONCOLOGY RESEARCH. 2020;22(9):390-398
- Article: BMC GENOMICS. 2020;21(1):590
- Article: ELIFE. 2020;9:e57894
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(6):1047-1057
- Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2020;8(1):e000204
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(4):608-623
- Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419
- Article: CIRCULATION RESEARCH. 2020;126(5):571-585
- Article: FRONTIERS IN ONCOLOGY. 2020;10:51
- Article: PLANT PHYSIOLOGY. 2019;181(4):1632-1650
- Article: AGING CELL. 2019;18(6):e13029
- Article: ISCIENCE. 2019;21:188-204
- Article: SCIENTIFIC REPORTS. 2019;9(1):16504
- Article: THE FASEB JOURNAL. 2019;33(9):10193-10206
- Article: SCIENTIFIC REPORTS. 2019;9(1):8324
- Article: NATURE COMMUNICATIONS. 2019;10(1):2331
- Article: CLINICAL CANCER RESEARCH. 2019;25(10):3115-3127
- Article: ELIFE. 2019;8:e41608
- Article: NATURE COMMUNICATIONS. 2019;10(1):1600
- Article: NATURE COMMUNICATIONS. 2019;10(1):1519
- Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):62
- Article: MOLECULAR CELL. 2019;73(1):166-182.e7
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2708
- Article: THE PLANT JOURNAL. 2018;96(4):705-715
- Article: SCIENTIFIC REPORTS. 2018;8(1):15841
- Article: CELL DEATH AND DISEASE. 2018;9(9):846
- Article: JACC: BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):464-480
- Article: SCIENTIFIC REPORTS. 2018;8(1):10813
- Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2018;470:84-95
- Article: NATURE BIOTECHNOLOGY. 2018;36(6):521-529
- Article: SCIENTIFIC REPORTS. 2018;8(1):9182
- Article: BMC BIOLOGY. 2018;16(1):47
- Article: NATURE COMMUNICATIONS. 2018;9(1):903
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(6):E1229-E1238
- Article: MOLECULAR PLANT. 2018;11(2):342-345
- Article: JOURNAL OF MOLECULAR BIOLOGY. 2018;430(3):348-362
- Article: BRAIN. 2018;141(2):582-595
- Article: SCIENTIFIC REPORTS. 2018;8(1):498
- Article: ADVANCES IN BIOLOGICAL REGULATION. 2018;67:128-133
- Article: SCIENTIFIC REPORTS. 2017;7(1):15453
- Article: ONCOTARGET. 2017;8(44):77061-77074
- Article: BMC CANCER. 2017;17(1):650
- Article: CELL DEATH AND DISEASE. 2017;8(8):e3029
- Article: ANALYTICAL CHEMISTRY. 2017;89(14):7356-7364
- Article: SCIENTIFIC REPORTS. 2017;7(1):4513
- Article: NUCLEIC ACIDS RESEARCH (NAR). 2017;45(5):2629-2643
- Article: IEEE/ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS. 2017;14(2):272-281
- Article: NATURE CHEMICAL BIOLOGY. 2017;13(1):15-17
- Article: METABOLOMICS. 2017;13(5):61
- Article: ANNALS OF ONCOLOGY. 2016;27(12):2275-2283
- Article: SCIENTIFIC REPORTS. 2016;6:35712
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2016;101(10):3616-3627
- Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2016;36(9):1947-1961
- Article: NUCLEIC ACIDS RESEARCH (NAR). 2016;44(14):6756-6769
- Article: ONCOTARGET. 2016;7(16):21332-21346
- Article: SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES. 2016;33(1):17-28
- Article: SCIENTIFIC REPORTS. 2016;6:22519
- Article: STEM CELLS. 2016;34(3):601-613
- Article: HUMAN MOLECULAR GENETICS. 2015;24(23):6756-6768
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(42):25254-25272
- Article: STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(10):1199-1213
- Article: EXPERIMENTAL CELL RESEARCH. 2015;336(1):158-170
- Article: NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE. 2015;11(4):879-883
- Article: NATURE MEDICINE. 2015;21(4):314-317
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(13):8348-8359
- Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26883
- Article: CLINICAL PROTEOMICS. 2015;12(1):8
- Article: PLOS ONE. 2015;10(5):e0126472
- Article: BIOMED RESEARCH INTERNATIONAL. 2015;2015:462549-13
- Article: JOURNAL OF PROTEOME RESEARCH. 2014;13(10):4424-4435
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2014;13(6):1611-1624
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2014;13(6):1552-1562
- Article: BRITISH JOURNAL OF CANCER. 2014;110(10):2489-2495
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2014;13(3):701-715
- Article: JOURNAL OF PROTEOMICS. 2014;96:133-144
- Article: NATURE METHODS. 2014;11(1):59-62
- Article: PLOS ONE. 2014;9(2):e87951
- Article: ONCOGENE. 2013;32(49):5531-5540
- Article: BMC MEDICAL GENOMICS. 2013;6:53
- Article: PROTEOMICS. 2013;13(23-24):3406-3410
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(43):17189-17194
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(40):E3761-E3769
- Article: JOURNAL OF PROTEOME RESEARCH. 2013;12(9):3934-3943
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2013;12(7):2021-2031
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(25):10258-10263
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(22):15556-15570
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2013;12(2):407-425
- Article: JOURNAL OF PROTEOME RESEARCH. 2013;12(2):1014-1019
- Article: MBIO. 2013;4(1):e00572-e00512
- Article: NATURE COMMUNICATIONS. 2013;4:2175
- Article: FREE RADICAL BIOLOGY AND MEDICINE. 2012;53(11):2188-2195
- Article: BMC BIOINFORMATICS. 2012;13:226
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2012;11(7):M112.016998
- Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2012;113(5):1635-1644
- Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY (EJE). 2012;166(4):657-667
- Article: NATURE COMMUNICATIONS. 2012;3:976
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2011;10(10):M111.010264
- Article: PROTEIN SCIENCE. 2011;20(9):1520-1529
- Article: JOURNAL OF PROTEOME RESEARCH. 2011;10(6):2703-2714
- Article: JOURNAL OF PROTEOME RESEARCH. 2011;10(5):2566-2578
- Article: NUCLEIC ACIDS RESEARCH (NAR). 2011;39(9):3972-3987
- Article: JOURNAL OF PROTEOME RESEARCH. 2011;10(4):1848-1859
- Article: AMINO ACIDS. 2011;40(2):697-711
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2011;125(2):457-465
- Article: EUROPEAN JOURNAL OF CANCER. 2011;47(1):131-137
- Article: THYROID. 2010;20(10):1067-1076
- Article: BMC BIOINFORMATICS. 2010;11:468
- Article: PROTEOME SCIENCE. 2009;7:43
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(41):27827-27837
- Article: ANNALS OF ONCOLOGY. 2009;20(10):1639-1646
- Article: BMC BIOINFORMATICS. 2009;10:272
- Article: PROTEOMICS. 2009;9(13):3414-3424
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2009;8(5):1117-1129
- Article: JOURNAL OF CHROMATOGRAPHY B: ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2009;877(13):1306-1316
- Article: LUNG CANCER. 2009;63(3):410-417
- Article: PROTEOMICS. 2008;8(15):3008-3018
- Article: JOURNAL OF PROTEOME RESEARCH. 2008;7(7):2712-2722
- Article: JOURNAL OF PROTEOME RESEARCH. 2008;7(6):2332-2341
- Article: ANALYTICAL CHEMISTRY. 2008;80(2):421-429
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2007;6(12):2122-2131
- Article: PROTEOMICS. 2006;6(23):6124-6133
- Article: JOURNAL OF BIOTECHNOLOGY. 2006;126(4):582-586
- Article: BIOINFORMATICS. 2006;22(12):1515-1523
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;342(4):1211-1217
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(2):484-489
- Article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2001;67(10):4678-4684
- Article: PROTEIN ENGINEERING, DESIGN AND SELECTION. 2001;14(9):711-715
- Article: FEMS MICROBIOLOGY LETTERS. 2001;195(2):197-204
- Article: PROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS. 2000;41(3):316-322
- Article: JOURNAL OF BIOTECHNOLOGY. 1997;57(1-3):49-57
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All other publications
- Review: JOURNAL OF INTERNAL MEDICINE. 2023;294(4):455-481
- Corrigendum: NATURE CANCER. 2022;3(5):649
- Letter: NATURE MEDICINE. 2020;26(7):992-994
- Corrigendum: SCIENTIFIC REPORTS. 2019;9(1):15014
- Corrigendum: NATURE COMMUNICATIONS. 2018;9(1):1852
- Review: ENVIRONMENTAL MICROBIOLOGY. 2017;19(6):2301-2319
- Letter: NATURE BIOTECHNOLOGY. 2015;33(2):137-139
- Review: EXPERT REVIEW OF PROTEOMICS. 2014;11(4):431-448
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:A80
- Review: THE FEBS JOURNAL. 2012;279(21):4062-4080
- Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2012;48:43
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a12
- Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2011;47:S124
- Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2011;47:S78
- Meeting abstract: BREAST. 2011;20:S25
- Review: JOURNAL OF PROTEOMICS. 2010;73(10):1851-1863
- Review: PROTEOMICS. 2009;9(6):1420-1427
- Review: PROTEOMICS - CLINICAL APPLICATIONS. 2007;1(9):1058-1065
- Meeting abstract: JOURNAL OF THORACIC ONCOLOGY. 2007;2(8):S356-S357
- Published conference paper: PROTEOMICS. 2007;7(11):1746-1752
- Published conference paper: LECTURE NOTES IN COMPUTER SCIENCE (INCLUDING SUBSERIES LECTURE NOTES IN ARTIFICIAL INTELLIGENCE AND LECTURE NOTES IN BIOINFORMATICS). 2005;3695:140-150
- Review: JOURNAL OF BIOTECHNOLOGY. 2002;96(1):67-78
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Employments
- Professor/Clinical Chemist, Department of Oncology-Pathology, Karolinska Institutet, 2021-
Degrees and Education
- Docent, Karolinska Institutet, 2009