Jana de Boniface
Om mig
Jana de Boniface är adjungerad professor i klinisk epidemiologi vid institutionen för medicinsk epidemiologi och biostatistik från den 1 maj 2024. Hon är också överläkare och kirurg på kirurg- och onkologikliniken på Capio S:t Görans Sjukhus.
Forskningsbeskrivning
Jana de Boniface forskar om bröstcancer med fokus på kirurgiska frågeställningar: Kan vi göra mindre omfattande operationer och ändå behålla samma goda resultat? Hennes forskning fokuserar på kirurgi i bröstet och kirurgi i armhålan. Hon har visat att bröstbevarande kirurgi, där enbart tumören tas bort och den friska delen av bröstet sparas, ger en bättre överlevnad än om hela bröstet tas bort. Resultatet pekar mot att komplikationer efter operationen, som är vanligare när hela bröstet tas bort, kan spela en roll för senare återfall och död. SENOMAC-studien, en stor randomiserad studie som letts av Jana de Boniface, har visat att man också kan avstå mer omfattande kirurgi om de första 1–2 lymfknutorna i armhålan är angripna. Enligt Jana de Boniface finns goda skäl att avstå onödigt omfattande operationer, med hänsyn till patientens livskvalitet och återgång till vardagsliv och arbete. Införandet av nya och mer effektiva läkemedel gör också att de kirurgiska ingreppen kan bli mindre. Då krävs forskning som visar var den rätta balansen ligger.
Artiklar
- Article: THE LANCET REGIONAL HEALTH. EUROPE. 2024;47:101083
- Article: JAMA SURGERY. 2024;159(12):1393-1403
- Article: JOURNAL OF ADVANCED NURSING. 2024
- Article: BJS OPEN. 2024;8(5):zrae095
- Article: THE LANCET ONCOLOGY. 2024;25(9):1222-1230
- Article: BRITISH JOURNAL OF SURGERY. 2024;111(9):znae240
- Journal article: BRITISH JOURNAL OF SURGERY. 2024;111:znae175.023
- Journal article: BRITISH JOURNAL OF SURGERY. 2024;111:znae175.112
- Article: RADIOTHERAPY AND ONCOLOGY. 2024;197:110372
- Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(16_suppl):579
- Journal article: SENOLOGIE - ZEITSCHRIFT FÜR MAMMADIAGNOSTIK UND -THERAPIE. 2024;21(02):e2-e3
- Journal article: SENOLOGIE - ZEITSCHRIFT FÜR MAMMADIAGNOSTIK UND -THERAPIE. 2024;21(02):e9-e10
- Journal article: SENOLOGIE - ZEITSCHRIFT FÜR MAMMADIAGNOSTIK UND -THERAPIE. 2024;21(02):e27
- Journal article: CANCER RESEARCH. 2024;84(9):po3-23-03-po3-23-03
- Journal article: CANCER RESEARCH. 2024;84(9):po1-19-03-po1-19-03
- Journal article: CANCER RESEARCH. 2024;84(9):po4-19-04-po4-19-04
- Journal article: CANCER RESEARCH. 2024;84(9):po1-19-06-po1-19-06
- Journal article: CANCER RESEARCH. 2024;84(9):po5-19-02-po5-19-02
- Journal article: CANCER RESEARCH. 2024;84(9):po4-18-12-po4-18-12
- Journal article: CANCER RESEARCH. 2024;84(9):po1-23-02-po1-23-02
- Journal article: CANCER RESEARCH. 2024;84(9):gs02-06-gs02-06
- Journal article: RADIOTHERAPY AND ONCOLOGY. 2024;194:s56-s57
- Article: THE LANCET REGIONAL HEALTH. AMERICAS. 2024;33:100734
- Article: NEW ENGLAND JOURNAL OF MEDICINE. 2024;390(13):1163-1175
- Journal article: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2024;50(2):107446
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2023;202(3):497-504
- Article: BREAST CARE. 2023;18(6):428-439
- Article: ANNALS OF ONCOLOGY. 2023;34(11):970-986
- Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2023;41(16_suppl):tps626
- Article: ARCHIVES OF GYNECOLOGY AND OBSTETRICS. 2023;307(5):1547-1556
- Article: LAKARTIDNINGEN. 2023;120:22149
- Journal article: BREAST. 2023;68:s7-s8
- Article: BRITISH JOURNAL OF SURGERY. 2023;110(3):344-352
- Article: JOURNAL OF PLASTIC, RECONSTRUCTIVE AND AESTHETIC SURGERY. 2023;76:18-26
- Article: BRITISH JOURNAL OF SURGERY. 2022;109(11):1107-1115
- Article: BRITISH JOURNAL OF SURGERY. 2022;109(10):977-983
- Article: JAMA NETWORK OPEN. 2022;5(9):e2231583
- Article: BRITISH JOURNAL OF SURGERY. 2022;109(9):857-863
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2022;193(3):589-595
- Journal article: TUMOR DIAGNOSTIK UND THERAPIE. 2022;43(03):197-203
- Journal article: SENOLOGIE - ZEITSCHRIFT FÜR MAMMADIAGNOSTIK UND -THERAPIE. 2022;19(01):49-55
- Article: ANNALS OF SURGICAL ONCOLOGY. 2022;29(2):1061-1070
- Journal article: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2022;48(2):e30
- Article: BRITISH JOURNAL OF SURGERY. 2021;108(12):1474-1482
- Article: BRITISH JOURNAL OF SURGERY. 2021;108(9):1105-1111
- Journal article: RADIOTHERAPY AND ONCOLOGY. 2021;161:s42-s43
- Article: JAMA SURGERY. 2021;156(7):628-637
- Article: BRITISH JOURNAL OF SURGERY. 2021;108(5):583-589
- Article: BRITISH JOURNAL OF SURGERY. 2021;108(3):302-307
- Journal article: CANCER RESEARCH. 2021;81(4_Supplement):ot-23-03-ot-23-03
- Journal article: CANCER RESEARCH. 2021;81(4_Supplement):ot-04-02-ot-04-02
- Article: BJS OPEN. 2021;5(1):zraa013
- Journal article: BRITISH JOURNAL OF SURGERY. 2021;108(3):302-307
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2020;184(3):977-984
- Journal article: EUROPEAN JOURNAL OF CANCER. 2020;138:s3
- Journal article: EUROPEAN JOURNAL OF CANCER. 2020;138:s36
- Journal article: EUROPEAN JOURNAL OF CANCER. 2020;138:s22
- Journal article: EUROPEAN JOURNAL OF CANCER. 2020;138:s3
- Journal article: EUROPEAN JOURNAL OF CANCER. 2020;138:s28-s29
- Journal article: EUROPEAN JOURNAL OF CANCER. 2020;138:s95
- Article: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2020;46(10):1867-1873
- Article: BJS OPEN. 2020;4(2):232-240
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(3):1185-1198
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2020;180(1):167-176
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2020;179(3):721-729
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2019;177(2):469-475
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2019;174(3):795-805
- Article: BRITISH JOURNAL OF SURGERY. 2018;105(12):1607-1614
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2018;171(2):359-369
- Journal article: EUROPEAN JOURNAL OF CANCER. 2018;92:s68
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2017;163(1):103-110
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2017;163(1):93-101
- Article: LAKARTIDNINGEN. 2017;114:EECT
- Article: BRITISH JOURNAL OF SURGERY. 2017;104(3):238-247
- Article: BRITISH JOURNAL OF SURGERY. 2016;103(12):1640-1648
- Journal article: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2016;42(9):s101-s102
- Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2016;14(1):227
- Article: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2014;40(10):1209-1215
- Article: BRITISH JOURNAL OF CANCER. 2014;111(5):918-926
- Article: BRITISH JOURNAL OF SURGERY. 2014;101(5):488-494
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2013;142(3):591-601
- Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2013;11:290
- Article: BRITISH JOURNAL OF SURGERY. 2013;100(6):775-783
- Article: PLOS ONE. 2013;8(2):e56795
- Article: ONCOIMMUNOLOGY. 2012;1(8):1305-1312
- Article: INTERNATIONAL JOURNAL OF CANCER. 2012;131(7):1611-1620
- Article: INTERNATIONAL JOURNAL OF CANCER. 2012;131(1):129-139
- Article: BRITISH JOURNAL OF SURGERY. 2012;99(2):226-231
- Article: BREAST CANCER: BASIC AND CLINICAL RESEARCH. 2012;6:bcbcr.s8642-38
- Article: JOURNAL OF CLINICAL ONCOLOGY. 2010;28(17):2868-2873
- Article: ANNALS OF SURGERY. 2008;247(1):150-156
- Article: BRITISH JOURNAL OF SURGERY. 2007;94(8):948-951
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2002;74(1):33-40
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Alla övriga publikationer
- Review: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2024;50(10):108554
- Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(16)
- Review: ECLINICALMEDICINE. 2023;61:102085
- Review: SCANDINAVIAN JOURNAL OF SURGERY. 2023;112(2):117-125
- Review: CANCER TREATMENT REVIEWS. 2023;117:102556
- Review: EUROPEAN JOURNAL OF CANCER. 2023;181:79-91
- Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2023;41(16)
- Conference publication: BREAST. 2023;68:S7-S8
- Conference publication: GEBURTSHILFE UND FRAUENHEILKUNDE. 2022;82(6):S47-S48
- Conference publication: SENOLOGIE - ZEITSCHRIFT FÜR MAMMADIAGNOSTIK UND -THERAPIE. 2022;19(02):e15
- Conference publication: ANNALS OF ONCOLOGY. 2022;33:S178-S179
- Conference publication: CANCER RESEARCH. 2022;82(4):p1-01-16-p1-01-16
- Conference publication: CANCER RESEARCH. 2022;82(4):ot1-04-04-ot1-04-04
- Editorial comment: ANNALS OF SURGICAL ONCOLOGY. 2022;29(2):1073-1075
- Letter: JAMA SURGERY. 2022;157(2):174-175
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2022;45(SUPPL 3):24-25
- Review: GEBURTSHILFE UND FRAUENHEILKUNDE. 2021;81(10):1121-1127
- Conference publication: SENOLOGIE - ZEITSCHRIFT FÜR MAMMADIAGNOSTIK UND -THERAPIE. 2021;18(02):e2
- Conference publication: CANCER RESEARCH. 2021;81(4)
- Conference publication: RADIOTHERAPY AND ONCOLOGY. 2021;161:S42-S43
- Conference publication: CANCER RESEARCH. 2021;81(4)
- Conference publication: BREAST. 2021;56:S69
- Conference publication: GEBURTSHILFE UND FRAUENHEILKUNDE. 2020;80(10):E93-E94
- Conference publication: GEBURTSHILFE UND FRAUENHEILKUNDE. 2020;80(10):E112
- Review: THE LANCET ONCOLOGY. 2020;21(8):e375-e385
- Conference publication: GEBURTSHILFE UND FRAUENHEILKUNDE. 2020;80(06):E20-E21
- Conference publication: GEBURTSHILFE UND FRAUENHEILKUNDE. 2020;80(06):E36
- Conference publication: SENOLOGIE - ZEITSCHRIFT FÜR MAMMADIAGNOSTIK UND -THERAPIE. 2020;17(02):e2
- Conference publication: SENOLOGIE - ZEITSCHRIFT FÜR MAMMADIAGNOSTIK UND -THERAPIE. 2020;17(02):e17-e18
- Editorial comment: BREAST CARE. 2020;15(2):188-191
- Conference publication: CANCER RESEARCH. 2020;80(4):ot3-01-01-ot3-01-01
- Review: CURRENT OPINION IN OBSTETRICS AND GYNECOLOGY. 2020;32(1):91-99
- Conference publication: EUROPEAN JOURNAL OF CANCER. 2020;138:S36
- Conference publication: EUROPEAN JOURNAL OF CANCER. 2020;138:S22
- Conference publication: EUROPEAN JOURNAL OF CANCER. 2020;138:S3
- Conference publication: EUROPEAN JOURNAL OF CANCER. 2020;138:S3
- Conference publication: EUROPEAN JOURNAL OF CANCER. 2020;138:S28-S29
- Conference publication: EUROPEAN JOURNAL OF CANCER. 2020;138:S95
- Letter: THE LANCET ONCOLOGY. 2019;20(1):e1
- Review: BREAST CANCER RESEARCH AND TREATMENT. 2018;172(3):523-537
- Review: BREAST CARE. 2018;13(5):331-336
- Review: BREAST CARE. 2018;13(5):337-341
- Published conference paper: BRITISH JOURNAL OF SURGERY. 2018;105(11):1435-1445
- Conference publication: CANCER RESEARCH. 2018;78(4_Supplement):p4-13-14-p4-13-14
- Conference publication: VIRCHOWS ARCHIV. 2018;473:S199
- Book chapter: BREAST CANCER MANAGEMENT FOR SURGEONS. 2018;p. 355-364
- Conference publication: EUROPEAN JOURNAL OF CANCER. 2018;92:S68
- Conference publication: CANCER RESEARCH. 2018;78(4)
- Letter: BRITISH JOURNAL OF SURGERY. 2013;100(10):1399
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Forskningsbidrag
- Swedish Research Council1 January 2022 - 31 December 2025
- Swedish Research Council1 December 2021 - 30 November 2025
- Swiss National Science Foundation1 August 2019 - 31 July 2025
- Survival and axillary recurrence following sentinel node-positive breast cancer without completion axillary lymph node dissection – the randomized controlled SENOMAC trial.Swedish Cancer Society1 January 2019
- Do you need to evacuate several lymph nodes from the armpit at early breast cancer with microscopic spread to sentinel node (the porter gland)?Swedish Cancer Society1 January 2017
- Do you need to evacuate several lymph nodes from the armpit at early breast cancer with microscopic spread to sentinel node (the porter gland)?Swedish Cancer Society1 January 2016
- Swedish Research Council1 January 2015 - 31 December 2017
- Do you need to evacuate several lymph nodes from the armpit at early breast cancer with microscopic spread to sentinel node (the porter gland)?Swedish Cancer Society1 January 2015
Anställningar
- Adjungerad Professor, Medicinsk epidemiologi och biostatistik, Karolinska Institutet, 2024-2028
Examina och utbildning
- Docent, kirurgi, Karolinska Institutet, 2014