Jan Andersson
Anknuten till Forskning
E-postadress: jan.andersson@ki.se
Telefon: +46852482904
Besöksadress: Alfred Nobels allé 8, plan 7, 14152 Huddinge
Postadress: H7 Medicin, Huddinge, H7 CIM Brighenti, 171 77 Stockholm
Om mig
- Jan Andersson utnämndes att från den 1 december 1998 vara professor i infektionssjukdomar vid Karolinska Institutet.
Jan Andersson är född i Örgryte 1951. Han studerade medicin vid Karolinska Institutet och avlade läkarexamen 1978.
Han blev medicine doktor 1985 på en avhandling om Epstein Barr-virus, det virus som orsakar körtelfeber. I avhandlingen visades att sjukdomssymtomen är en följd av kroppens reaktion på smittämnet och inte av smittämnet i sig. 1987 blev han docent i infektionsmedicin. När Karolinska sjukhuset initierade en infektionsenhet 1991 utnämndes Jan Andersson till överläkare. Han erhöll ett lektorat i infektionsmedicin 1995. Sedan 1997 driver han ett infektionslaboratorium vid Karolinska Universitetssjukhuset, Huddinge och tjänstgör vid avdelningen för infektionssjukdomar, institutionen för medicin.
I takt med upptäckten att kontroll av infektionssjukdomar styrs av immunsystemets förmåga att producera cytokiner utvecklade hans grupp metoder att studera produktion på en-cellsnivå. Med dessa har han klarlagt immunsvaret vid körtelfeber samt vid hiv-infektion. Bägge är generella virusinfektioner som i första fallet läker ut hos samtliga drabbade medan 99, 7% av hiv-smittade får en grav immunbrist som om den står obehandlad blir livshotande. Han visade att detta delvis beror på att cellbundna immunsystemet ej kan avdöda hiv infekterade celler i motsats till körtelfeber. Normalisering av denna defekt är av central betydelse för att skapa kontroll av hiv-infektion. Denna forskning pågår nu i centrum för Infektionsmedicin (CIM) som han var med om att skapa
Forskningsbeskrivning
- Sedan år 1981, när de första AIDS-sjuka började uppmärksammas i USA, har 60 miljoner människor världen över smittats med HIV, och sammanlagt har 25 miljoner människor dött i AIDS. I dag är sjukdomen mest utbredd i Afrika, söder om Sahara. Nu dominerar heterosexuell smitta och unga kvinnor drabbas särskilt hårt. Bromsmediciner har utvecklats som radikalt förlänger livet på smittade, dock hittills utan att leda till bot. Förståelse om hur immuniteten fungerar hos de ca 0.3% smittade som kontrollerar sin hiv infektion kan komma att utgöra ett fundament för framtida vaccin och immunstärkande biologisk terapi för försök till hiv-bot.
Artiklar
- Article: NUTRIENTS. 2018;10(6):E721-721
- Article: JOURNAL OF IMMUNOLOGY. 2015;195(4):1698-1704
- Article: CLINICAL IMMUNOLOGY. 2015;156(2):85-97
- Article: CLINICAL IMMUNOLOGY. 2014;151(2):84-99
- Article: AIDS. 2013;27(7):1071-1080
- Article: THORAX. 2013;68(3):269-276
- Article: BLOOD. 2013;121(7):1124-1135
- Article: SHOCK. 2012;38(6):577-583
- Article: JOURNAL OF INFECTIOUS DISEASES. 2012;205:S316-S324
- Article: JOURNAL OF INFECTIOUS DISEASES. 2012;205:s325-s334
- Article: BMC INFECTIOUS DISEASES. 2012;12:111
- Article: MOLECULAR MEDICINE. 2012;18(4):647-658
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;75(2):249-258
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132(1):114-123
- Article: BMJ OPEN. 2012;2(6):e001663
- Article: GENES AND IMMUNITY. 2011;12(7):513-522
- Article: PLOS ONE. 2011;6(1):e16425
- Article: PLOS ONE. 2011;6(8):e24394
- Article: INFECTION ECOLOGY & EPIDEMIOLOGY. 2011;1:6029
- Article: PLOS ONE. 2011;6(12):e29316
- Article: IMMUNOLOGY. 2010;131(1):128-140
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;176(6):2798-2805
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):116-119
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):50-57
- Article: NEUROGASTROENTEROLOGY AND MOTILITY. 2010;22(1):70-e29
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(1):134-141
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2009;348(1-2):42-56
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2009;346(1-2):1-8
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2009;174(6):2211-2224
- Article: CLINICAL AND VACCINE IMMUNOLOGY. 2009;16(4):521-527
- Article: HIV MEDICINE. 2009;10(2):94-102
- Article: JOURNAL OF INTERNAL MEDICINE. 2009;265(1):5-17
- Article: ACTA DERMATO-VENEREOLOGICA. 2009;89(4):393-397
- Article: CRITICAL CARE MEDICINE. 2008;36(3):716-723
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2007;37(12):3352-3362
- Article: JOURNAL OF VIROLOGY. 2007;81(21):11593-11603
- Article: INFECTION AND IMMUNITY. 2007;75(11):5210-5222
- Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2007;27(6):589-597
- Article: CRITICAL CARE MEDICINE. 2007;35(6):1536-1542
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2007;45(1):9-19
- Article: AIDS. 2007;21(5):565-574
- Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2007;23(3):398-406
- Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2007;23(1):101-106
- Article: BLOOD. 2006;108(12):3808-3817
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2006;43(2):137-143
- Article: AIDS REVIEWS. 2006;8(3):141-147
- Article: MICROBES AND INFECTION. 2006;8(8):1985-1993
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(24):9178-9183
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(18):7000-7005
- Article: CYTOKINE. 2006;34(1-2):17-23
- Article: AIDS. 2006;20(1):11-19
- Article: JOURNAL OF INFECTIOUS DISEASES. 2005;192(4):607-617
- Article: JOURNAL OF VIROLOGY. 2005;79(14):8861-8869
- Article: JOURNAL OF IMMUNOLOGY. 2005;174(6):3143-3147
- Article: CRITICAL CARE MEDICINE. 2005;33(3):564-573
- Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2005;81(2):495-502
- Article: JOURNAL OF INTERNAL MEDICINE. 2005;257(2):122-125
- Article: CLINICAL SCIENCE. 2005;108(2):179-184
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;60(6):566-573
- Article: CLINICAL AND VACCINE IMMUNOLOGY. 2004;11(6):1022-1027
- Article: BLOOD. 2004;104(9):2810-2817
- Article: JOURNAL OF IMMUNOLOGY. 2004;173(1):641-648
- Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2004;79(3):444-450
- Article: JOURNAL OF MEDICAL PRIMATOLOGY. 2004;33(1):16-24
- Article: METHODS IN MOLECULAR BIOLOGY. 2004;249:201-218
- Article: CRITICAL CARE MEDICINE. 2004;32(1):1-12
- Article: BONE MARROW TRANSPLANTATION. 2004;33(1):79-85
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2004;36(9):663-669
- Article: JOURNAL OF INTERNAL MEDICINE. 2003;254(4):375-385
- Article: VIROLOGY. 2003;314(1):179-189
- Article: CLINICAL INFECTIOUS DISEASES. 2003;37(3):333-340
- Article: JOURNAL OF INFECTIOUS DISEASES. 2003;188(3):364-370
- Article: AIDS. 2003;17(9):1303-1310
- Article: INFECTION AND IMMUNITY. 2003;71(5):2684-2692
- Article: JOURNAL OF IMMUNOLOGY. 2002;169(10):5771-5779
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2002;130(2):263-270
- Article: INFECTION AND IMMUNITY. 2002;70(6):3199-3207
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(4):414-423
- Article: AIDS. 2002;16(5):683-692
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;115(1):32-41
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;124(3):423-428
- Article: JOURNAL OF VIROLOGY. 2001;75(17):8195-8202
- Article: JOURNAL OF VIRAL HEPATITIS. 2001;8(4):287-292
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2001;249(1-2):207-222
- Article: NATURE CELL BIOLOGY. 2001;3(2):150-157
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2001;107(3):287-294
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2001;33(5):323-328
- Article: NATURE MEDICINE. 2001;7(1):73-79
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2000;157(6):1811-1818
- Article: CLINICAL INFECTIOUS DISEASES. 2000;31(5):1175-1182
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2000;25(2):150-156
- Article: INFECTION AND IMMUNITY. 2000;68(9):5329-5334
- Article: INFECTION AND IMMUNITY. 2000;68(6):3620-3629
- Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 1999;14(12):2937-2940
- Article: AIDS. 1999;13(15):2013-2021
- Article: BRITISH JOURNAL OF CANCER. 1999;81(2):359-366
- Article: JOURNAL OF INFECTIOUS DISEASES. 1999;180(2):410-418
- Article: AIDS. 1999;13(11):1295-1303
- Article: JOURNAL OF IMMUNOLOGY. 1999;163(2):736-742
- Article: SCIENCE. 1999;285(5425):248-251
- Article: TRANSPLANT INFECTIOUS DISEASE. 1999;1(2):89-97
- Article: CLINICAL IMMUNOLOGY. 1999;91(3):254-262
- Article: CLINICAL INFECTIOUS DISEASES. 1999;28(5):1036-1042
- Article: CLINICAL INFECTIOUS DISEASES. 1998;27(6):1428-1436
- Article: BONE MARROW TRANSPLANTATION. 1998;22(8):795-800
- Article: AMERICAN JOURNAL OF PATHOLOGY. 1998;153(2):481-490
- Article: AIDS. 1998;12(11):f123-f129
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 1998;214(1-2):97-111
- Article: CLINICAL INFECTIOUS DISEASES. 1998;26(3):631-638
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1998;47(3):229-235
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1998;30(4):339-343
- Article: ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY. 1998;60(1):35-41
- Article: INFECTION AND IMMUNITY. 1997;65(12):5338-5341
- Article: JOURNAL OF INFECTIOUS DISEASES. 1997;176(5):1303-1312
- Article: CRITICAL CARE MEDICINE. 1997;25(7):1115-1124
- Article: TRANSPLANTATION. 1997;63(12):1782-1789
- Article: BONE MARROW TRANSPLANTATION. 1997;19(9):905-908
- Article: AMERICAN JOURNAL OF PATHOLOGY. 1997;150(5):1607-1618
- Article: INFECTION AND IMMUNITY. 1996;64(12):5395-5398
- Article: IMMUNOLOGY LETTERS. 1996;54(1):45-52
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1996;44(4):345-353
- Article: JOURNAL OF INFECTIOUS DISEASES. 1996;174(2):324-331
- Article: CLINICAL INFECTIOUS DISEASES. 1996;23(1):167-169
- Article: ACTA OTO-LARYNGOLOGICA. 1996;116(3):477-485
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(5):1130-1138
- Article: JOURNAL OF IMMUNOLOGY. 1996;156(8):3057-3064
- Article: GUT. 1996;38(3):328-336
- Article: JOURNAL OF LEUKOCYTE BIOLOGY. 1996;59(2):287-295
- Article: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 1996;85(2):168-172
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(1):1-9
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1996;28(6):625-628
- Article: IMMUNOLOGY. 1995;86(4):512-518
- Article: ACTA OTO-LARYNGOLOGICA. 1995;115(5):689-696
- Article: ANNALS OF THE RHEUMATIC DISEASES. 1995;54(8):654-661
- Article: JOURNAL OF INFECTIOUS DISEASES. 1995;171(2):376-384
- Article: NORDISK MEDICIN. 1995;110(12):320-321
- Article: INFECTION AND IMMUNITY. 1995;63(1):289-296
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Alla övriga publikationer
- Published conference paper: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2019;104:10-20
- Review: JOURNAL OF INTERNAL MEDICINE. 2015;277(4):388-405
- Review: JOURNAL OF INTERNAL MEDICINE. 2015;277(4):373-387
- Letter: TRANSPLANTATION. 2014;98(12):e95-e96
- Letter: THORAX. 2011;66(8):727-729
- Published conference paper: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2009;51(3):239-247
- Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2009;199(5):702-710
- Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2008;263(3):215-217
- Review: HERPES : THE JOURNAL OF THE IHMF. 2006;13(1):12-16
- Review: CURRENT HIV/AIDS REPORTS. 2006;3(1):32-38
- Editorial comment: CURRENT OPINION IN IMMUNOLOGY. 2002;14(4):409-412
- Corrigendum: INFECTION AND IMMUNITY. 2002;70(8):4754
- Published conference paper: MOLECULAR IMMUNOLOGY. 2002;38(12-13):921-929
- Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2002;185(9):1355-1358
- Letter: BLOOD. 2002;99(5):1877
- Editorial comment: VACCINE. 2002;20(15):1895
- Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2001;184(7):853-860
- Review: BLOOD. 2001;98(6):1667-1677
- Letter: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2001;16(8):1729
- Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2000;182(6):1625-1635
- Meeting abstract: GASTROENTEROLOGY. 2000;118(4):A1362
- Letter: NATURE MEDICINE. 1999;5(6):592
- Corrigendum: JOURNAL OF IMMUNOLOGICAL METHODS. 1998;218(1-2):173-187
- Published conference paper: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS, SUPPLEMENT. 1998;87:61-64
- Letter: CLINICAL NEPHROLOGY. 1998;49(1):67-68
- Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1996;797:299-301
- Published conference paper: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, SUPPLEMENT. 1996;100:72-82
- Published conference paper: INFUSIONSTHERAPIE UND TRANSFUSIONSMEDIZIN. 1996;23:7-14
- Published conference paper: TRANSPLANTATION PROCEEDINGS. 1995;27(6):3530
- Published conference paper: TRANSPLANTATION PROCEEDINGS. 1995;27(1):1224-1225
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