Jakob Wikström
Senior Forskare | Docent
E-postadress: jakob.wikstrom@ki.se
Besöksadress: L8 CMM plan 2, Karolinska universitetssjukhuset, 17176 Stockholm
Postadress: K2 Medicin, Solna, K2 Derm o Ven Wikström J, 171 77 Stockholm
Om mig
- 2016 - G.B. Morgagni pris i diabetesforkning (Universitetet i
Padova Italien)
Forskningsbeskrivning
- Mitokondrier och endoplasmatiskt retikulum i sårläkning och sällsynta
hudsjukdomar
Kroniska bensår orsakar avsevärt lidande hos äldre och konsumerar 2 % av
sjukvårdsbudgeten - trots detta är sårläkningsprocessen otillräckligt
förstådd och tillgängliga behandlingar idag ofta bristfälliga.
Mitokondrier är cellulära organeller som producerar 90 % av energimolekylen
ATP vilken är nödvändig för de flesta biologiska reaktioner inklusive de
som behövs för sårläkning. För att producera ATP konsumerar
mitokondrierna 90 % av kroppens syrgas. Eftersom sårläkning kräver mycket
energi och de flesta sår har låga syrenivåer studerar vi mitokondriernas
roll i sårläkning. Vidare undersöker även de ärftliga sällsynta
hudjukdomarna Dariers och Hailey-Hailey´s – kontakta gärna Dr Jakob
Wikström om du önskar delta i klinisk forskning.
Artiklar
- Journal article: COMMUNICATIONS BIOLOGY. 2024;7(1):1534
- Article: EMBO MOLECULAR MEDICINE. 2024;16(9):1986-2001
- Article: BRITISH JOURNAL OF DERMATOLOGY. 2024;191(3):462-463
- Article: JCI INSIGHT. 2024;9(9):e169213
- Article: SCIENTIFIC REPORTS. 2024;14(1):7109
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(23):16954
- Article: ACTA DERMATO-VENEREOLOGICA. 2023;103:adv10436
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(10):2039-2051.e10
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(18):14331
- Article: MICROBIOME. 2023;11(1):162
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):s251
- Article: JOURNAL OF NEURORADIOLOGY. 2022;49(6):421-427
- Journal article: 2022
- Article: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 2022;111(4):809-811
- Article: JOURNAL OF WOUND CARE. 2022;31(1):4-11
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(10):s163
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2021;218(8):e20201708
- Article: ACTA DERMATO-VENEREOLOGICA. 2021;101(6):adv00476
- Journal article: ACTA RADIOLOGICA OPEN. 2021;10(4):20584601211006315
- Article: JOURNAL OF WOUND CARE. 2021;30(3):210-212
- Article: INTERNATIONAL WOUND JOURNAL. 2021;18(1):49-61
- Article: SCIENTIFIC REPORTS. 2020;10(1):6886
- Journal article: AMERICAN JOURNAL OF NEURORADIOLOGY. 2020;41(3):430-436
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2020;140(2):465-476.e11
- Article: DIABETES. 2020;69(2):131-145
- Article: DIABETOLOGY AND METABOLIC SYNDROME. 2020;12(1):12
- Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2019;98(7):865-876
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(6):1373-1384
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(19):9443-9452
- Journal article: NEURORADIOLOGY. 2019;61(1):43-53
- Article: CELL METABOLISM. 2018;27(4):869-885.e6
- Article: NEUROPSYCHOPHARMACOLOGY. 2018;43(3):555-563
- Article: PLOS ONE. 2018;13(10):e0205517
- Article: DERMATOLOGY PRACTICAL & CONCEPTUAL. 2018;8(2):85-88
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(10):s306
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(10):s306
- Article: SCIENTIFIC REPORTS. 2017;7(1):7797
- Journal article: ULTRASOUND IN OBSTETRICS AND GYNECOLOGY. 2017;49(3):410-412
- Article: PLOS ONE. 2017;12(10):e0186356
- Article: DIABETOLOGIA. 2016;59(7):1480-1491
- Journal article: ULTRASOUND IN OBSTETRICS AND GYNECOLOGY. 2016;47(6):673
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(34):20934-20946
- Article: STROKE. 2015;46(5):1374-1376
- Article: JOURNAL OF STROKE AND CEREBROVASCULAR DISEASES. 2015;24(2):312-318
- Journal article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2014;34(6):457-462
- Article: NEUROIMAGE. 2014;99:215-225
- Article: NEUROPSYCHOLOGIA. 2014;61:291-298
- Article: EMBO JOURNAL. 2014;33(5):418-436
- Article: BIOLOGY OF MOOD AND ANXIETY DISORDERS. 2014;4(1):3
- Article: MITOCHONDRION. 2013;13(6):662-667
- Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23(11):1474-1483
- Article: BEHAVIOURAL BRAIN RESEARCH. 2013;256:219-228
- Article: MOLECULAR ENDOCRINOLOGY. 2013;27(10):1706-1723
- Article: CLEFT PALATE-CRANIOFACIAL JOURNAL. 2013;50(5):513-519
- Article: PSYCHONEUROENDOCRINOLOGY. 2013;38(7):1133-1144
- Article: DIABETES. 2013;62(4):1227-1237
- Article: HUMAN MOLECULAR GENETICS. 2012;21(5):978-990
- Article: AMERICAN JOURNAL OF NEURORADIOLOGY. 2012;33(3):513-518
- Article: PLOS ONE. 2012;7(5):e33023
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(49):42534-42544
- Article: NEURORADIOLOGY. 2011;53(12):1001-1008
- Article: DIABETES. 2011;60(11):2710-2719
- Article: NEURORADIOLOGY JOURNAL. 2011;24(3):461-463
- Article: PLOS ONE. 2011;6(10):e26883
- Article: NEURORADIOLOGY. 2011;53(1):43-48
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2010;299(2):C477-C487
- Article: CELL. 2010;140(2):280-293
- Journal article: JOURNAL OF MAGNETIC RESONANCE IMAGING. 2010;31(1):39-45
- Article: DIABETES. 2009;58(10):2303-2315
- Journal article: ATHEROSCLEROSIS. 2009;205(1):163-167
- Journal article: ACTA RADIOLOGICA. 2009;50(1):55-60
- Journal article: EUROPEAN RADIOLOGY. 2008;18(6):1174-1180
- Journal article: ACTA RADIOLOGICA. 2008;49(2):190-196
- Journal article: ACTA RADIOLOGICA. 2008;49(2):143-149
- Article: NATURE MEDICINE. 2008;14(2):144-153
- Article: EMBO JOURNAL. 2008;27(2):433-446
- Article: DIABETES. 2007;56(10):2569-2578
- Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2007;27(3):649-654
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2006;291(1):C176-C184
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2006;290(1):E143-E148
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;287(6):E1090-E1099
- Article: DIABETOLOGIA. 2004;47(Suppl 1):a1-a464
- Journal article: EUROPEAN RADIOLOGY. 2003;13(5):957-963
- Journal article: ACTA RADIOLOGICA. 2002;43(3):256-261
- Journal article: ACTA RADIOLOGICA, SUPPLEMENT. 2001;42(426):1-30
- Journal article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2000;19(5):516-523
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Alla övriga publikationer
- Letter: BRITISH JOURNAL OF DERMATOLOGY. 2024;190(2):284-285
- Conference publication: EXPERIMENTAL DERMATOLOGY. 2024;33(3)
- Corrigendum: MICROBIOME. 2023;11(1):206
- Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2023;11:1252318
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):S251
- Review: ACTA DERMATO-VENEREOLOGICA. 2021;101(4):adv00430
- Corrigendum: PLOS ONE. 2021;16(1):e0246145
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(10):S163
- Letter: BRITISH JOURNAL OF DERMATOLOGY. 2020;182(6):1500-1502
- Letter: ACTA DERMATO-VENEREOLOGICA. 2020;100(6):adv00082-2
- Letter: JOURNAL OF AMERICAN ACADEMY OF DERMATOLOGY. 2019;81(6):1425-1426
- Letter: JOURNAL OF AMERICAN ACADEMY OF DERMATOLOGY. 2019;81(2):624-627
- Conference publication: WOUND REPAIR AND REGENERATION. 2019;27(3):A37
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(5):S246
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(10):S306
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(10):S306
- Review: ACTA NEUROLOGICA SCANDINAVICA. 2017;135(1):17-24
- Corrigendum: DIABETOLOGIA. 2016;59(7):1575-1576
- Editorial comment: AUTOPHAGY. 2013;9(4):626-628
- Corrigendum: DIABETES. 2011;60(12):3307
- Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2009;41(10):1914-1927
- Review: NOVARTIS FOUNDATION SYMPOSIUM. 2007;287:21-36
- Conference publication: ACTA RADIOLOGICA. 2007;48(4):422-430
- Conference publication: DIABETOLOGIA. 2003;46:A172
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Forskningsbidrag
- Swedish Research Council1 December 2020 - 31 December 2024
- Endoplasmic reticulum stress in chronic leg ulcers: a new treatment strategy?Swedish Research Council1 January 2019 - 31 December 2021
- Swedish Research Council1 January 2017 - 31 December 2020
Anställningar
- Senior Forskare, Medicin, Solna, Karolinska Institutet, 2022-
Examina och utbildning
- Docent, Dermatologi, Karolinska Institutet, 2020