Jakob Wikström
Senior Forskare
| Docent
E-postadress: jakob.wikstrom@ki.se
Besöksadress: L8 CMM plan 2, Karolinska universitetssjukhuset, 17176 Stockholm
Postadress: K2 Medicin, Solna, K2 Derm o Ven Wikström J, 171 77 Stockholm
Om mig
- 2016 - G.B. Morgagni pris i diabetesforkning (Universitetet i
Padova Italien)
Forskningsbeskrivning
- Mitokondrier och endoplasmatiskt retikulum i sårläkning och sällsynta
hudsjukdomar
Kroniska bensår orsakar avsevärt lidande hos äldre och konsumerar 2 % av
sjukvårdsbudgeten - trots detta är sårläkningsprocessen otillräckligt
förstådd och tillgängliga behandlingar idag ofta bristfälliga.
Mitokondrier är cellulära organeller som producerar 90 % av energimolekylen
ATP vilken är nödvändig för de flesta biologiska reaktioner inklusive de
som behövs för sårläkning. För att producera ATP konsumerar
mitokondrierna 90 % av kroppens syrgas. Eftersom sårläkning kräver mycket
energi och de flesta sår har låga syrenivåer studerar vi mitokondriernas
roll i sårläkning. Vidare undersöker även de ärftliga sällsynta
hudjukdomarna Dariers och Hailey-Hailey´s – kontakta gärna Dr Jakob
Wikström om du önskar delta i klinisk forskning.
Artiklar
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Article: BRITISH JOURNAL OF DERMATOLOGY. 2024;191(3):462-463
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Journal article: EMBO MOLECULAR MEDICINE. 2024;:1-16
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Article: JCI INSIGHT. 2024;9(9):e169213
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Article: SCIENTIFIC REPORTS. 2024;14(1):7109
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Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(23):16954
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Article: ACTA DERMATO-VENEREOLOGICA. 2023;103:adv10436
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Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(10):2039-2051.e10
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Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(18):14331
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Article: MICROBIOME. 2023;11(1):162
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Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):s251
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Article: JOURNAL OF NEURORADIOLOGY. 2022;49(6):421-427
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Journal article: 2022
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Article: ACTA PAEDIATRICA. 2022;111(4):809-811
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Article: JOURNAL OF WOUND CARE. 2022;31(1):4-11
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Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(10):s163
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Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2021;218(8):e20201708
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Article: ACTA DERMATO-VENEREOLOGICA. 2021;101(6):adv00476
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Journal article: ACTA RADIOLOGICA OPEN. 2021;10(4):205846012110063
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Article: JOURNAL OF WOUND CARE. 2021;30(3):210-212
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Article: INTERNATIONAL WOUND JOURNAL. 2021;18(1):49-61
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Article: SCIENTIFIC REPORTS. 2020;10(1):6886
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Journal article: AMERICAN JOURNAL OF NEURORADIOLOGY. 2020;41(3):430-436
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Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2020;140(2):465-476.e11
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Article: DIABETES. 2020;69(2):131-145
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Article: DIABETOLOGY & METABOLIC SYNDROME. 2020;12(1):12
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Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2019;98(7):865-876
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Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(6):1373-1384
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(19):9443-9452
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Journal article: NEURORADIOLOGY. 2019;61(1):43-53
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Article: CELL METABOLISM. 2018;27(4):869-885.e6
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Article: NEUROPSYCHOPHARMACOLOGY. 2018;43(3):555-563
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Article: PLOS ONE. 2018;13(10):e0205517
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Article: DERMATOLOGY PRACTICAL & CONCEPTUAL. 2018;8(2):85-88
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Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(10):s306
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Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(10):s306
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Article: SCIENTIFIC REPORTS. 2017;7(1):7797
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Journal article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2017;49(3):410-412
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Article: PLOS ONE. 2017;12(10):e0186356
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Article: DIABETOLOGIA. 2016;59(7):1480-1491
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Journal article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2016;47(6):673
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(34):20934-20946
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Article: STROKE. 2015;46(5):1374-1376
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Article: JOURNAL OF STROKE & CEREBROVASCULAR DISEASES. 2015;24(2):312-318
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Journal article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2014;34(6):457-462
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Article: NEUROIMAGE. 2014;99:215-225
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Article: NEUROPSYCHOLOGIA. 2014;61:291-298
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Article: EMBO JOURNAL. 2014;33(5):418-436
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Article: BIOLOGY OF MOOD AND ANXIETY DISORDERS. 2014;4(1):3
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Article: MITOCHONDRION. 2013;13(6):662-667
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Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23(11):1474-1483
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Article: BEHAVIOURAL BRAIN RESEARCH. 2013;256:219-228
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Article: MOLECULAR ENDOCRINOLOGY. 2013;27(10):1706-1723
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Article: CLEFT PALATE CRANIOFACIAL JOURNAL. 2013;50(5):513-519
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Article: PSYCHONEUROENDOCRINOLOGY. 2013;38(7):1133-1144
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Article: DIABETES. 2013;62(4):1227-1237
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Article: HUMAN MOLECULAR GENETICS. 2012;21(5):978-990
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Article: AMERICAN JOURNAL OF NEURORADIOLOGY. 2012;33(3):513-518
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Article: PLOS ONE. 2012;7(5):e33023
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(49):42534-42544
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Article: NEURORADIOLOGY. 2011;53(12):1001-1008
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Article: DIABETES. 2011;60(11):2710-2719
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Article: JOURNAL OF NEURORADIOLOGY. 2011;24(3):461-463
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Article: PLOS ONE. 2011;6(10):e26883
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Article: NEURORADIOLOGY. 2011;53(1):43-48
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Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2010;299(2):C477-C487
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Article: CELL. 2010;140(2):280-293
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Journal article: JOURNAL OF MAGNETIC RESONANCE IMAGING. 2010;31(1):39-45
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Article: DIABETES. 2009;58(10):2303-2315
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Journal article: ATHEROSCLEROSIS. 2009;205(1):163-167
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Journal article: ACTA RADIOLOGICA. 2009;50(1):55-60
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Journal article: EUROPEAN RADIOLOGY. 2008;18(6):1174-1180
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Journal article: ACTA RADIOLOGICA. 2008;49(2):190-196
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Journal article: ACTA RADIOLOGICA. 2008;49(2):143-149
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Article: NATURE MEDICINE. 2008;14(2):144-153
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Article: EMBO JOURNAL. 2008;27(2):433-446
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Article: DIABETES. 2007;56(10):2569-2578
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Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2007;27(3):649-654
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Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2006;291(1):C176-C184
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Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2006;290(1):E143-E148
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Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2004;287(6):E1090-E1099
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Article: DIABETOLOGIA. 2004;47(Suppl 1):a1-a464
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Journal article: EUROPEAN RADIOLOGY. 2003;13(5):957-963
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Journal article: ACTA RADIOLOGICA. 2002;43(3):256-261
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Journal article: ACTA RADIOLOGICA, SUPPLEMENT. 2001;42(426):1-30
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Journal article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2000;19(5):516-523
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Alla övriga publikationer
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Letter: BRITISH JOURNAL OF DERMATOLOGY. 2024;190(2):284-285
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Conference publication: EXPERIMENTAL DERMATOLOGY. 2024;33(3)
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Corrigendum: MICROBIOME. 2023;11(1):206
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Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2023;11:1252318
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Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):S251
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Review: ACTA DERMATO-VENEREOLOGICA. 2021;101(4):adv00430
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Corrigendum: PLOS ONE. 2021;16(1):e0246145
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Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(10):S163
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Letter: BRITISH JOURNAL OF DERMATOLOGY. 2020;182(6):1500-1502
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Letter: ACTA DERMATO-VENEREOLOGICA. 2020;100(6):adv00082-2
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Letter: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 2019;81(6):1425-1426
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Letter: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 2019;81(2):624-627
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Conference publication: WOUND REPAIR AND REGENERATION. 2019;27(3):A37
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Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(5):S246
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Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(10):S306
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Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(10):S306
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Review: ACTA NEUROLOGICA SCANDINAVICA. 2017;135(1):17-24
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Corrigendum: DIABETOLOGIA. 2016;59(7):1575-1576
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Editorial comment: AUTOPHAGY. 2013;9(4):626-628
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Corrigendum: DIABETES. 2011;60(12):3307
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Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2009;41(10):1914-1927
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Review: NOVARTIS FOUNDATION SYMPOSIUM. 2007;287:21-36
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Conference publication: ACTA RADIOLOGICA. 2007;48(4):422-430
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Conference publication: DIABETOLOGIA. 2003;46:A172
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Forskningsbidrag
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Swedish Research Council1 December 2020 - 31 December 2024
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Endoplasmic reticulum stress in chronic leg ulcers: a new treatment strategy?Swedish Research Council1 January 2019 - 31 December 2021
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Swedish Research Council1 January 2017 - 31 December 2020
Anställningar
- Senior Forskare, Medicin, Solna, Karolinska Institutet, 2022-
Examina och utbildning
- Docent, Dermatologi, Karolinska Institutet, 2020