Jakob Wikström
Principal Researcher | Docent
E-mail: jakob.wikstrom@ki.se
Visiting address: L8 CMM plan 2, Karolinska universitetssjukhuset, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Derm o Ven Wikström J, 171 77 Stockholm
About me
- My clinical specialty is dermato-venereology and my scientific focus is on
the cell biology of common and rare skin diseases.
2016 - G.B. Morgagni Young investigator Award in Diabetes
research (University of Padua, Italy)
Research
- Mitochondria and endoplasmic reticulum in wound healing and rare skin
conditions
Chronic leg ulcers cause great suffering in the elderly and consume 2 % of
the health budget - yet the wound healing process is incompletely understood
and today´s treatments are often inadequate. Mitochondria produce 90 % of
the cell’s ATP, which is essential for most biological reactions including
those involved in wound healing. To achieve this, mitochondria consume 90 %
of the body´s oxygen. As wound healing has high energy requirements and the
hypoxic nature of most wounds we are currently studying the role of
mitochondria in the healing of chronic leg ulcers.
We also study rare genetic conditions Darier´s disease and Hailey-Hailey´s
disease, which are caused by disrupted calcium homeostasis in the endoplasmic
reticulum and Golgi apparatus, respectively. Our aim is to gain better
understanding of these diseases and to conduct a bedside-to-bench study in
which we aim to develop improved therapies. Please contact Dr Jakob Wikström
if you are a patient or healthy volunteer and would like to take part in this
cutting edge research.
We are always looking for highly motivated scientists interested in joining
our growing team.
Articles
- Journal article: COMMUNICATIONS BIOLOGY. 2024;7(1):1534
- Article: EMBO MOLECULAR MEDICINE. 2024;16(9):1986-2001
- Article: BRITISH JOURNAL OF DERMATOLOGY. 2024;191(3):462-463
- Article: JCI INSIGHT. 2024;9(9):e169213
- Article: SCIENTIFIC REPORTS. 2024;14(1):7109
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(23):16954
- Article: ACTA DERMATO-VENEREOLOGICA. 2023;103:adv10436
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(10):2039-2051.e10
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(18):14331
- Article: MICROBIOME. 2023;11(1):162
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):s251
- Article: JOURNAL OF NEURORADIOLOGY. 2022;49(6):421-427
- Journal article: 2022
- Article: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 2022;111(4):809-811
- Article: JOURNAL OF WOUND CARE. 2022;31(1):4-11
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(10):s163
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2021;218(8):e20201708
- Article: ACTA DERMATO-VENEREOLOGICA. 2021;101(6):adv00476
- Journal article: ACTA RADIOLOGICA OPEN. 2021;10(4):20584601211006315
- Article: JOURNAL OF WOUND CARE. 2021;30(3):210-212
- Article: INTERNATIONAL WOUND JOURNAL. 2021;18(1):49-61
- Article: SCIENTIFIC REPORTS. 2020;10(1):6886
- Journal article: AMERICAN JOURNAL OF NEURORADIOLOGY. 2020;41(3):430-436
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2020;140(2):465-476.e11
- Article: DIABETES. 2020;69(2):131-145
- Article: DIABETOLOGY AND METABOLIC SYNDROME. 2020;12(1):12
- Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2019;98(7):865-876
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(6):1373-1384
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(19):9443-9452
- Journal article: NEURORADIOLOGY. 2019;61(1):43-53
- Article: CELL METABOLISM. 2018;27(4):869-885.e6
- Article: NEUROPSYCHOPHARMACOLOGY. 2018;43(3):555-563
- Article: PLOS ONE. 2018;13(10):e0205517
- Article: DERMATOLOGY PRACTICAL & CONCEPTUAL. 2018;8(2):85-88
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(10):s306
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(10):s306
- Article: SCIENTIFIC REPORTS. 2017;7(1):7797
- Journal article: ULTRASOUND IN OBSTETRICS AND GYNECOLOGY. 2017;49(3):410-412
- Article: PLOS ONE. 2017;12(10):e0186356
- Article: DIABETOLOGIA. 2016;59(7):1480-1491
- Journal article: ULTRASOUND IN OBSTETRICS AND GYNECOLOGY. 2016;47(6):673
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(34):20934-20946
- Article: STROKE. 2015;46(5):1374-1376
- Article: JOURNAL OF STROKE AND CEREBROVASCULAR DISEASES. 2015;24(2):312-318
- Journal article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2014;34(6):457-462
- Article: NEUROIMAGE. 2014;99:215-225
- Article: NEUROPSYCHOLOGIA. 2014;61:291-298
- Article: EMBO JOURNAL. 2014;33(5):418-436
- Article: BIOLOGY OF MOOD AND ANXIETY DISORDERS. 2014;4(1):3
- Article: MITOCHONDRION. 2013;13(6):662-667
- Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23(11):1474-1483
- Article: BEHAVIOURAL BRAIN RESEARCH. 2013;256:219-228
- Article: MOLECULAR ENDOCRINOLOGY. 2013;27(10):1706-1723
- Article: CLEFT PALATE-CRANIOFACIAL JOURNAL. 2013;50(5):513-519
- Article: PSYCHONEUROENDOCRINOLOGY. 2013;38(7):1133-1144
- Article: DIABETES. 2013;62(4):1227-1237
- Article: HUMAN MOLECULAR GENETICS. 2012;21(5):978-990
- Article: AMERICAN JOURNAL OF NEURORADIOLOGY. 2012;33(3):513-518
- Article: PLOS ONE. 2012;7(5):e33023
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(49):42534-42544
- Article: NEURORADIOLOGY. 2011;53(12):1001-1008
- Article: DIABETES. 2011;60(11):2710-2719
- Article: NEURORADIOLOGY JOURNAL. 2011;24(3):461-463
- Article: PLOS ONE. 2011;6(10):e26883
- Article: NEURORADIOLOGY. 2011;53(1):43-48
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2010;299(2):C477-C487
- Article: CELL. 2010;140(2):280-293
- Journal article: JOURNAL OF MAGNETIC RESONANCE IMAGING. 2010;31(1):39-45
- Article: DIABETES. 2009;58(10):2303-2315
- Journal article: ATHEROSCLEROSIS. 2009;205(1):163-167
- Journal article: ACTA RADIOLOGICA. 2009;50(1):55-60
- Journal article: EUROPEAN RADIOLOGY. 2008;18(6):1174-1180
- Journal article: ACTA RADIOLOGICA. 2008;49(2):190-196
- Journal article: ACTA RADIOLOGICA. 2008;49(2):143-149
- Article: NATURE MEDICINE. 2008;14(2):144-153
- Article: EMBO JOURNAL. 2008;27(2):433-446
- Article: DIABETES. 2007;56(10):2569-2578
- Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2007;27(3):649-654
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2006;291(1):C176-C184
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2006;290(1):E143-E148
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;287(6):E1090-E1099
- Article: DIABETOLOGIA. 2004;47(Suppl 1):a1-a464
- Journal article: EUROPEAN RADIOLOGY. 2003;13(5):957-963
- Journal article: ACTA RADIOLOGICA. 2002;43(3):256-261
- Journal article: ACTA RADIOLOGICA, SUPPLEMENT. 2001;42(426):1-30
- Journal article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2000;19(5):516-523
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All other publications
- Letter: BRITISH JOURNAL OF DERMATOLOGY. 2024;190(2):284-285
- Conference publication: EXPERIMENTAL DERMATOLOGY. 2024;33(3)
- Corrigendum: MICROBIOME. 2023;11(1):206
- Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2023;11:1252318
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):S251
- Review: ACTA DERMATO-VENEREOLOGICA. 2021;101(4):adv00430
- Corrigendum: PLOS ONE. 2021;16(1):e0246145
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(10):S163
- Letter: BRITISH JOURNAL OF DERMATOLOGY. 2020;182(6):1500-1502
- Letter: ACTA DERMATO-VENEREOLOGICA. 2020;100(6):adv00082-2
- Letter: JOURNAL OF AMERICAN ACADEMY OF DERMATOLOGY. 2019;81(6):1425-1426
- Letter: JOURNAL OF AMERICAN ACADEMY OF DERMATOLOGY. 2019;81(2):624-627
- Conference publication: WOUND REPAIR AND REGENERATION. 2019;27(3):A37
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(5):S246
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(10):S306
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(10):S306
- Review: ACTA NEUROLOGICA SCANDINAVICA. 2017;135(1):17-24
- Corrigendum: DIABETOLOGIA. 2016;59(7):1575-1576
- Editorial comment: AUTOPHAGY. 2013;9(4):626-628
- Corrigendum: DIABETES. 2011;60(12):3307
- Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2009;41(10):1914-1927
- Review: NOVARTIS FOUNDATION SYMPOSIUM. 2007;287:21-36
- Conference publication: ACTA RADIOLOGICA. 2007;48(4):422-430
- Conference publication: DIABETOLOGIA. 2003;46:A172
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Grants
- Swedish Research Council1 December 2020 - 31 December 2024
- Endoplasmic reticulum stress in chronic leg ulcers: a new treatment strategy?Swedish Research Council1 January 2019 - 31 December 2021
- Swedish Research Council1 January 2017 - 31 December 2020
Employments
- Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2020