Jakob Wikström

Jakob Wikström

Principal Researcher | Docent
Visiting address: L8 CMM plan 2, Karolinska universitetssjukhuset, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Derm o Ven Wikström J, 171 77 Stockholm
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About me

  • My clinical specialty is dermato-venereology and my scientific focus is on
    the cell biology of common and rare skin diseases.
    2016 - G.B. Morgagni Young investigator Award in Diabetes
    research (University of Padua, Italy)

Research

  • Mitochondria and endoplasmic reticulum in wound healing and rare skin
    conditions
    Chronic leg ulcers cause great suffering in the elderly and consume 2 % of
    the health budget; yet the wound healing process is incompletely understood
    and today´s treatments are often inadequate. Mitochondria produce 90 % of
    the cell’s ATP, which is essential for most biological reactions including
    those involved in wound healing. To achieve this, mitochondria consume 90 %
    of the body´s oxygen. As wound healing has high energy requirements and the
    hypoxic nature of most wounds we are currently studying the role of
    mitochondria in the healing of chronic leg ulcers.
    We also study rare genetic conditions Darier´s disease and Hailey-Hailey´s
    disease, which are caused by disrupted calcium homeostasis in the endoplasmic
    reticulum and Golgi apparatus, respectively. Our aim is to gain better
    understanding of these diseases and to conduct a bedside-to-bench study in
    which we aim to develop improved therapies. Please contact Dr Jakob Wikström
    if you are a patient or healthy volunteer and would like to take part in this
    cutting edge research.
    We are always looking for highly motivated scientists interested in joining
    our growing team.

Articles

All other publications

Grants

Employments

  • Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-

Degrees and Education

  • Docent, Karolinska Institutet, 2020

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