Jakob Wikström
Principal Researcher
| Docent
E-mail: jakob.wikstrom@ki.se
Visiting address: L8 CMM plan 2, Karolinska universitetssjukhuset, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Derm o Ven Wikström J, 171 77 Stockholm
About me
- My clinical specialty is dermato-venereology and my scientific focus is on
the cell biology of common and rare skin diseases.
2016 - G.B. Morgagni Young investigator Award in Diabetes
research (University of Padua, Italy)
Research
- Mitochondria and endoplasmic reticulum in wound healing and rare skin
conditions
Chronic leg ulcers cause great suffering in the elderly and consume 2 % of
the health budget - yet the wound healing process is incompletely understood
and today´s treatments are often inadequate. Mitochondria produce 90 % of
the cell’s ATP, which is essential for most biological reactions including
those involved in wound healing. To achieve this, mitochondria consume 90 %
of the body´s oxygen. As wound healing has high energy requirements and the
hypoxic nature of most wounds we are currently studying the role of
mitochondria in the healing of chronic leg ulcers.
We also study rare genetic conditions Darier´s disease and Hailey-Hailey´s
disease, which are caused by disrupted calcium homeostasis in the endoplasmic
reticulum and Golgi apparatus, respectively. Our aim is to gain better
understanding of these diseases and to conduct a bedside-to-bench study in
which we aim to develop improved therapies. Please contact Dr Jakob Wikström
if you are a patient or healthy volunteer and would like to take part in this
cutting edge research.
We are always looking for highly motivated scientists interested in joining
our growing team.
Articles
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Article: SCIENTIFIC REPORTS. 2024;14(1):7109
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Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(10):2039-2051.e10
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Article: JOURNAL OF WOUND CARE. 2022;31(1):4-11
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Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2021;218(8):e20201708
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Article: ACTA DERMATO-VENEREOLOGICA. 2021;101(6):adv00476
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Article: JOURNAL OF WOUND CARE. 2021;30(3):210-212
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Article: INTERNATIONAL WOUND JOURNAL. 2021;18(1):49-61
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Article: SCIENTIFIC REPORTS. 2020;10(1):6886
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Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2020;140(2):465-476.e11
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Article: DIABETES. 2020;69(2):131-145
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Article: DIABETOLOGY & METABOLIC SYNDROME. 2020;12:12
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Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(6):1373-1384
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(19):9443-9452
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Article: CELL METABOLISM. 2018;27(4):869-885.e6
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Article: PLOS ONE. 2018;13(10):e0205517
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Article: DERMATOLOGY PRACTICAL & CONCEPTUAL. 2018;8(2):85-88
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Article: SCIENTIFIC REPORTS. 2017;7(1):7797
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Article: PLOS ONE. 2017;12(10):e0186356
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Article: DIABETOLOGIA. 2016;59(7):1480-1491
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(34):20934-20946
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Article: EMBO JOURNAL. 2014;33(5):418-436
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Article: MITOCHONDRION. 2013;13(6):662-667
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Article: MOLECULAR ENDOCRINOLOGY. 2013;27(10):1706-1723
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Article: DIABETES. 2013;62(4):1227-1237
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Article: HUMAN MOLECULAR GENETICS. 2012;21(5):978-990
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Article: PLOS ONE. 2012;7(5):e33023
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(49):42534-42544
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Article: DIABETES. 2011;60(11):2710-2719
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Article: PLOS ONE. 2011;6(10):e26883
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Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2010;299(2):C477-C487
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Article: CELL. 2010;140(2):280-293
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Article: DIABETES. 2009;58(10):2303-2315
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Article: NATURE MEDICINE. 2008;14(2):144-153
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Article: EMBO JOURNAL. 2008;27(2):433-446
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Article: DIABETES. 2007;56(10):2569-2578
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Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2006;291(1):C176-C184
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Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2006;290(1):E143-E148
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Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2004;287(6):E1090-E1099
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Article: DIABETOLOGIA. 2004;47(Suppl 1):a1-a464
- Show more
All other publications
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Review: ACTA DERMATO-VENEREOLOGICA. 2021;101(4):adv00430
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Corrigendum: PLOS ONE. 2021;16(1):e0246145
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Letter: BRITISH JOURNAL OF DERMATOLOGY. 2020;182(6):1500-1502
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Letter: ACTA DERMATO-VENEREOLOGICA. 2020;100(6):adv00082-2
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Letter: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 2019;81(6):1425-1426
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Letter: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 2019;81(2):624-627
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Corrigendum: DIABETOLOGIA. 2016;59(7):1575-1576
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Editorial comment: AUTOPHAGY. 2013;9(4):626-628
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Corrigendum: DIABETES. 2011;60(12):3307
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Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2009;41(10):1914-1927
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Review: NOVARTIS FOUNDATION SYMPOSIUM. 2007;287:21-36
Employments
- Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2020