Helen Håkansson
Professor Emeritus/Emerita | Docent
E-postadress: helen.hakansson@ki.se
Telefon: +46852487527
Mobiltelefon: +46705854078
Besöksadress: Nobels väg 13, 17177 Stockholm
Postadress: C6 Institutet för miljömedicin, C6 CVD-NUT-EPI Åkesson, 171 77 Stockholm
Om mig
- Min forskning handlar om receptor-medierad toxicitet, prevention och hälsoriskbedömning.
Forskningsbeskrivning
- Min forskning resulterar i data, som används i det nationella och internationella riskbedömningsarbetet kring persistenta organiska miljöföroreningar och andra hälsofarliga kemikalier. Studierna syftar till att klargöra molekylära verkningsmekanismer, identifiera kritiska effekter och effektnivåer, samt att fastlägga för människor säkra exponeringsnivåer. Sådan kunskap behövs för att kunna utveckla specifika och känsliga effekt- och exponeringsmarkörer
- kunskap som i sin tur behövs för att bättre kunna fastlägga orsakssamband i humana studier, samt för att kunna utveckla de specifika och känsliga testmetoder, som behövs inom den hälsobaserade kemikaliekontrollen.
Den experimentella forskningen är inriktad på receptor-medierad toxicitet med fokus på störningar i hormonella och metabola system. Sedan lång tid har jag ett särskilt intresse då det gäller retinoidsystemets känslighet för toxicitet medierad via Ah-receptorn. Sjukdomsbilder, som är relevanta för min forskning, inkluderar anomalier i benvävnad och kärl, cancer, fertilitetsproblem, beteendepåverkan samt olika typer av metabola sjukdomar. Just nu använder jag mig av olika modellsystem för att klargöra hur olika typer av kemikalier påverkar benvävnadens utveckling och homeostas.
Finansiering:
EU DG RES
EU DG SANCO
FORMAS
Naturvårdsverket
Fem utvalda publikationer:
Beronius A, Rudén C, Hanberg A, Håkansson H (2009)
Health risk assessment procedures for endocrine disrupting compounds within different regulatory frameworks in the European Union
Reg Tox Pharmacol. DOI: 10.1016/j.yrtph.2009.05.019
Beronius A, Rudén C, Håkansson H, Hanberg A (2009)
Risk to all or none? - A comparative analysis of controversies in the health risk assessment of Bisphenol A
Reproductive Toxicology (accepted)
Carpi D, Korkalainen M, Airoldi L, Fanelli R, Hakansson H, Muhonen V, Tuukkanen J, Viluksela M, Pastorelli R (2009)
Dioxin-sensitive proteins in differentiating osteoblasts: effects on bone formation in vitro
Toxicological Sciences, 108, 330-343.
Schuchardt JP, Wahlström D, Rüegg J, Giese N, Stefan M, Hopf H, Pongratz I, Håkansson H, Eichele G, Pettersson K, Nau H (2009)
The endogenous retinoid metabolite S-4-oxo-9-cis-13, 14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo
FEBS J, 276, 3043-3059.
Van der Ven LT, Van de Kuil T, Leonards PEG, Slob W, Lilienthal H, Litens S, Herlin M, Håkansson H, Canton RF, Van den Berg M, Visser TJ, van Loveren H, Vos JG, Piersma AH (2009)
Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats
Toxicology Letters, 185, 51-62.
Artiklar
- Article: REPRODUCTIVE TOXICOLOGY. 2022;107:123-139
- Article: REPRODUCTIVE TOXICOLOGY. 2021;105:25-43
- Article: JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2021;95:108762
- Article: REPRODUCTIVE TOXICOLOGY. 2021;102:109-127
- Article: REPRODUCTIVE TOXICOLOGY. 2021;101:33-49
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2019;370:56-64
- Article: ARCHIVES OF TOXICOLOGY. 2019;93(4):1157-1167
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2017;326:54-65
- Article: ARCHIVES OF TOXICOLOGY. 2017;91(2):1001-1006
- Article: PLOS ONE. 2017;12(9):e0185241
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2016;301:14-21
- Article: ARCHIVES OF TOXICOLOGY. 2016;90(3):701-715
- Article: TOXICOLOGY IN VITRO. 2015;29(5):876-883
- Article: TOXICOLOGY LETTERS. 2014;229(1):41-51
- Article: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES. 2014;77(5):223-245
- Article: PLOS ONE. 2014;9(8):e104639
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2013;273(1):219-226
- Article: ENVIRONMENT INTERNATIONAL. 2013;59:112-123
- Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2013;449:336-344
- Article: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 2013;65(3):325-333
- Article: JOURNAL OF APPLIED TOXICOLOGY. 2012;32(10):843-849
- Article: TOXICOLOGICAL SCIENCES. 2012;127(1):66-75
- Article: JOURNAL OF NUTRITION. 2011;141(12):2198-2203
- Article: TOXICOLOGY LETTERS. 2011;207(1):82-88
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2011;119(11):1590-1595
- Article: TOXICOLOGICAL SCIENCES. 2011;123(1):170-179
- Article: TOXICOLOGY. 2011;284(1-3):42-53
- Article: TOXICOLOGY LETTERS. 2011;202(2):75-84
- Article: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES. 2011;74(19):1304-1318
- Article: REPRODUCTIVE TOXICOLOGY. 2010;30(4):558-565
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2010;118(10):1389-1394
- Article: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 2010;57(2-3):136-145
- Article: CHEMOSPHERE. 2010;80(2):137-143
- Article: JOURNAL OF ENVIRONMENTAL MONITORING. 2010;12(5):1029-1036
- Article: JOURNAL OF BIOMECHANICS. 2010;43(6):1097-1103
- Article: REPRODUCTIVE TOXICOLOGY. 2010;29(2):132-146
- Article: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 2009;55(2):111-122
- Article: FEBS JOURNAL. 2009;276(11):3043-3059
- Article: TOXICOLOGICAL SCIENCES. 2009;108(2):330-343
- Article: TOXICOLOGY LETTERS. 2009;185(1):51-62
- Article: FOOD AND CHEMICAL TOXICOLOGY. 2008;46(11):3360-3367
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2008;116(9):1162-1166
- Article: TOXICOLOGIC PATHOLOGY. 2008;36(5):727-737
- Article: TOXICOLOGY LETTERS. 2008;179(1):6-14
- Article: TOXICOLOGY. 2008;245(1-2):76-89
- Article: TOXICOLOGY. 2008;245(1-2):109-122
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2008;116(3):334-339
- Article: REPRODUCTION IN DOMESTIC ANIMALS. 2008;43(1):124-126
- Article: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES. 2008;71(1-2):93-108
- Article: TOXICOLOGICAL SCIENCES. 2006;94(2):281-292
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2006;5(5):882-894
- Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2005;156(1):25-39
- Article: TOXICOLOGICAL SCIENCES. 2005;86(2):264-272
- Article: TOXICOLOGICAL SCIENCES. 2005;85(2):935-943
- Article: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2005;96(6):453-464
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2003;192(3):262-274
- Article: ARCHIVES OF TOXICOLOGY. 2003;77(7):371-383
- Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2003;145(1):1-16
- Article: BONE. 2002;31(6):685-689
- Article: TOXICOLOGICAL SCIENCES. 2002;70(2):171-182
- Article: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2002;91(5):232-244
- Article: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2002;91(5):220-231
- Article: TOXICOLOGICAL SCIENCES. 2001;62(1):166-175
- Article: ARCHIVES OF TOXICOLOGY. 2001;75(4):200-208
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2000;169(2):159-167
- Article: TOXICOLOGY. 2000;150(1-3):41-51
- Article: TOXICOLOGICAL SCIENCES. 2000;55(2):478-484
- Article: EMBO JOURNAL. 1999;18(18):4903-4914
- Article: ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. 1999;18(2):292-298
- Article: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES. 1998;55(5):331-344
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 1998;152(1):153-165
- Article: TOXICOLOGICAL SCIENCES. 1998;44(1):1-13
- Article: JOURNAL OF APPLIED TOXICOLOGY. 1998;18(4):285-292
- Article: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES. 1996;49(3):301-318
- Article: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. 1996;2(1):17-23
- Article: JOURNAL OF APPLIED TOXICOLOGY. 1996;16(2):121-128
- Article: CHEMOSPHERE. 1996;32(6):1225-1233
- Article: JOURNAL OF APPLIED TOXICOLOGY. 1995;15(6):455-463
- Article: FUNDAMENTAL AND APPLIED TOXICOLOGY. 1995;26(2):282-292
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Alla övriga publikationer
- Editorial comment: REPRODUCTIVE TOXICOLOGY. 2022;107:40-42
- Review: REPRODUCTIVE TOXICOLOGY. 2020;93:250-258
- Editorial comment: TOXICOLOGY LETTERS. 2016;259:151-155
- Letter: REPRODUCTIVE TOXICOLOGY. 2009;28(4):563-567
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S197-S198
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S240
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S146
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S147
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S15
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S244
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S103
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S104
- Meeting abstract: TOXICOLOGY LETTERS. 2008;180:S52
- Meeting abstract: TOXICOLOGY LETTERS. 2008;180:S245
- Meeting abstract: TOXICOLOGY LETTERS. 2008;180:S76
- Review: TOXICOLOGICAL SCIENCES. 2006;93(2):223-241
- Meeting abstract: TOXICOLOGY LETTERS. 2006;164:S74
- Review: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2005;207(1):1-24
- Corrigendum: ARCHIVES OF TOXICOLOGY. 2004;78(1):59
- Published conference paper: NEUROTOXICOLOGY. 2002;23(6):783-793
- Other: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2002;91(5):218-219
- Review: CRITICAL REVIEWS IN TOXICOLOGY. 2002;32(3):211-232
- Published conference paper: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2001;29(3):291-295
- Published conference paper: CHEMOSPHERE. 2001;43(4-7):807-814
- Published conference paper: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2000;169(2):121-131
- Published conference paper: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2000;165(3):184-194
- Published conference paper: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES. 1997;51(3):265-277
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Anställningar
- Professor Emeritus/Emerita, Institutet för miljömedicin, Karolinska Institutet, 2024-2025
Examina och utbildning
- Docent, inriktn. toxikologi, KI, Karolinska institutet, 1993