Helen Håkansson
Professor Emeritus/Emerita | Docent
E-mail: helen.hakansson@ki.se
Telephone: +46852487527
Mobile phone: +46705854078
Visiting address: Nobels väg 13, 17177 Stockholm
Postal address: C6 Institutet för miljömedicin, C6 CVD-NUT-EPI Åkesson, 171 77 Stockholm
About me
- My research is about receptor-mediated toxicity, prevention and health risk assessment.
Research
- My research generates data, which is used to support national and international health risk assessment work in the areas of persistent organic pollutants and other health hazardous chemicals. The studies aim to clarify the molecular mechanisms of action, identify critical effects and effect levels, and to establish safe exposure levels for humans. Such knowledge is needed to develop specific and sensitive effect- and exposure markers, which in turn, can be used to improve the possibilities to establish casual relationships in human studies, and also to develop specific and sensitive test methods within the health based risk and safety control of various categories of chemicals.
The experimental research in my group focuses on receptor-mediated toxicity and its consequences on hormonal and metabolic pathways. I have, since long, a particular interest in the retinoid system and it´s crosstalk with the Ah-receptor both in normal and toxicological situations. Disease categories that are relevant for my research include bone and vascular abnormalities, cancer, fertility problems, behavioral influences and different types of metabolic disorders. Right now, we use different model systems to clarify how different types of chemicals interfere with bone development and homeostasis.
Financing:
EU DG RES
EU DG SANCO
FORMAS
Swedish Environmental Protection Agency
Five selected publications:
Beronius A, Rudén C, Hanberg A, Håkansson H (2009)
Health risk assessment procedures for endocrine disrupting compounds within different regulatory frameworks in the European Union
Reg Tox Pharmacol. DOI: 10.1016/j.yrtph.2009.05.019
Beronius A, Rudén C, Håkansson H, Hanberg A (2009)
Risk to all or none? - A comparative analysis of controversies in the health risk assessment of Bisphenol A
Reproductive Toxicology (accepted)
Carpi D, Korkalainen M, Airoldi L, Fanelli R, Hakansson H, Muhonen V, Tuukkanen J, Viluksela M, Pastorelli R (2009)
Dioxin-sensitive proteins in differentiating osteoblasts: effects on bone formation in vitro
Toxicological Sciences, 108, 330-343.
Schuchardt JP, Wahlström D, Rüegg J, Giese N, Stefan M, Hopf H, Pongratz I, Håkansson H, Eichele G, Pettersson K, Nau H (2009)
The endogenous retinoid metabolite S-4-oxo-9-cis-13, 14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo
FEBS J, 276, 3043-3059.
Van der Ven LT, Van de Kuil T, Leonards PEG, Slob W, Lilienthal H, Litens S, Herlin M, Håkansson H, Canton RF, Van den Berg M, Visser TJ, van Loveren H, Vos JG, Piersma AH (2009)
Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats
Toxicology Letters, 185, 51-62.
Articles
- Article: REPRODUCTIVE TOXICOLOGY. 2022;107:123-139
- Article: REPRODUCTIVE TOXICOLOGY. 2021;105:25-43
- Article: JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2021;95:108762
- Article: REPRODUCTIVE TOXICOLOGY. 2021;102:109-127
- Article: REPRODUCTIVE TOXICOLOGY. 2021;101:33-49
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2019;370:56-64
- Article: ARCHIVES OF TOXICOLOGY. 2019;93(4):1157-1167
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2017;326:54-65
- Article: ARCHIVES OF TOXICOLOGY. 2017;91(2):1001-1006
- Article: PLOS ONE. 2017;12(9):e0185241
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2016;301:14-21
- Article: ARCHIVES OF TOXICOLOGY. 2016;90(3):701-715
- Article: TOXICOLOGY IN VITRO. 2015;29(5):876-883
- Article: TOXICOLOGY LETTERS. 2014;229(1):41-51
- Article: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. 2014;77(5):223-245
- Article: PLOS ONE. 2014;9(8):e104639
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2013;273(1):219-226
- Article: ENVIRONMENT INTERNATIONAL. 2013;59:112-123
- Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2013;449:336-344
- Article: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 2013;65(3):325-333
- Article: JOURNAL OF APPLIED TOXICOLOGY. 2012;32(10):843-849
- Article: TOXICOLOGICAL SCIENCES. 2012;127(1):66-75
- Article: JOURNAL OF NUTRITION. 2011;141(12):2198-2203
- Article: TOXICOLOGY LETTERS. 2011;207(1):82-88
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2011;119(11):1590-1595
- Article: TOXICOLOGICAL SCIENCES. 2011;123(1):170-179
- Article: TOXICOLOGY. 2011;284(1-3):42-53
- Article: TOXICOLOGY LETTERS. 2011;202(2):75-84
- Article: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. 2011;74(19):1304-1318
- Article: REPRODUCTIVE TOXICOLOGY. 2010;30(4):558-565
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2010;118(10):1389-1394
- Article: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 2010;57(2-3):136-145
- Article: CHEMOSPHERE. 2010;80(2):137-143
- Article: JOURNAL OF ENVIRONMENTAL MONITORING. 2010;12(5):1029-1036
- Article: JOURNAL OF BIOMECHANICS. 2010;43(6):1097-1103
- Article: REPRODUCTIVE TOXICOLOGY. 2010;29(2):132-146
- Article: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 2009;55(2):111-122
- Article: THE FEBS JOURNAL. 2009;276(11):3043-3059
- Article: TOXICOLOGICAL SCIENCES. 2009;108(2):330-343
- Article: TOXICOLOGY LETTERS. 2009;185(1):51-62
- Article: FOOD AND CHEMICAL TOXICOLOGY. 2008;46(11):3360-3367
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2008;116(9):1162-1166
- Article: TOXICOLOGIC PATHOLOGY. 2008;36(5):727-737
- Article: TOXICOLOGY LETTERS. 2008;179(1):6-14
- Article: TOXICOLOGY. 2008;245(1-2):76-89
- Article: TOXICOLOGY. 2008;245(1-2):109-122
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2008;116(3):334-339
- Article: REPRODUCTION IN DOMESTIC ANIMALS. 2008;43(1):124-126
- Article: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. 2008;71(1-2):93-108
- Article: TOXICOLOGICAL SCIENCES. 2006;94(2):281-292
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2006;5(5):882-894
- Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2005;156(1):25-39
- Article: TOXICOLOGICAL SCIENCES. 2005;86(2):264-272
- Article: TOXICOLOGICAL SCIENCES. 2005;85(2):935-943
- Article: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2005;96(6):453-464
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2003;192(3):262-274
- Article: ARCHIVES OF TOXICOLOGY. 2003;77(7):371-383
- Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2003;145(1):1-16
- Article: BONE. 2002;31(6):685-689
- Article: TOXICOLOGICAL SCIENCES. 2002;70(2):171-182
- Article: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2002;91(5):232-244
- Article: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2002;91(5):220-231
- Article: TOXICOLOGICAL SCIENCES. 2001;62(1):166-175
- Article: ARCHIVES OF TOXICOLOGY. 2001;75(4):200-208
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2000;169(2):159-167
- Article: TOXICOLOGY. 2000;150(1-3):41-51
- Article: TOXICOLOGICAL SCIENCES. 2000;55(2):478-484
- Article: EMBO JOURNAL. 1999;18(18):4903-4914
- Article: ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. 1999;18(2):292-298
- Article: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. 1998;55(5):331-344
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 1998;152(1):153-165
- Article: TOXICOLOGICAL SCIENCES. 1998;44(1):1-13
- Article: JOURNAL OF APPLIED TOXICOLOGY. 1998;18(4):285-292
- Article: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. 1996;49(3):301-318
- Article: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. 1996;2(1):17-23
- Article: JOURNAL OF APPLIED TOXICOLOGY. 1996;16(2):121-128
- Article: CHEMOSPHERE. 1996;32(6):1225-1233
- Article: JOURNAL OF APPLIED TOXICOLOGY. 1995;15(6):455-463
- Article: FUNDAMENTAL AND APPLIED TOXICOLOGY. 1995;26(2):282-292
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All other publications
- Editorial comment: REPRODUCTIVE TOXICOLOGY. 2022;107:40-42
- Review: REPRODUCTIVE TOXICOLOGY. 2020;93:250-258
- Editorial comment: TOXICOLOGY LETTERS. 2016;259:151-155
- Letter: REPRODUCTIVE TOXICOLOGY. 2009;28(4):563-567
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S197-S198
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S146
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S15
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S147
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S244
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S240
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S104
- Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S103
- Meeting abstract: TOXICOLOGY LETTERS. 2008;180:S52
- Meeting abstract: TOXICOLOGY LETTERS. 2008;180:S245
- Meeting abstract: TOXICOLOGY LETTERS. 2008;180:S76
- Review: TOXICOLOGICAL SCIENCES. 2006;93(2):223-241
- Meeting abstract: TOXICOLOGY LETTERS. 2006;164:S74
- Review: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2005;207(1):1-24
- Corrigendum: ARCHIVES OF TOXICOLOGY. 2004;78(1):59
- Published conference paper: NEUROTOXICOLOGY. 2002;23(6):783-793
- Other: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2002;91(5):218-219
- Review: CRITICAL REVIEWS IN TOXICOLOGY. 2002;32(3):211-232
- Published conference paper: CHEMOSPHERE. 2001;43(4-7):807-814
- Published conference paper: ATLA ALTERNATIVES TO LABORATORY ANIMALS. 2001;29(3):291-295
- Published conference paper: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2000;169(2):121-131
- Published conference paper: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2000;165(3):184-194
- Published conference paper: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. 1997;51(3):265-277
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Employments
- Professor Emeritus/Emerita, Institute of Environmental Medicine, Karolinska Institutet, 2024-2025
Degrees and Education
- Docent, Karolinska institutet, 1993