Hanna Björck

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Forskargruppsledare, enheten för Kardiologi, Inst. för MedS

Postdoc vid enheten för atherosklerosforskning, Institutionen för Medicin, Solna, Karolinska Institutet, 2012-2016
Doktorsexamen i Medicinsk Vetenskap – fysiologi, Linköpings universitet, januari 2012
Magisterexamen i Molekylärbiologi, Uppsala universitet, januari 2006
Uppsala Graduate School in Biomedical Research (UGSBR) – Uppsala universitet, januari 2006

Forskningsbeskrivning

Thorakalt aortaaneurysm manifesterar som en sjuklig vidgning av stora kroppspulsådern närmast hjärtat och kan leda till att blodkärlet brister.
Målsättningen med vår forskning är att klargöra de sjukdomsmekanismer som ligger bakom aneurysm i thorakala aorta samt det kliniska förloppet som följer. Projekten inkluderar kliniska såväl som experimentella frågeställningar och baseras på en stor välkarakteriserad patientkohort med tillhörande biobank. För mer information, se den engelskspråkiga profilsidan.

Undervisning

Kursledare för 1BIO48 Molecular Medicine – Cardiometabolic and
Infectious diseases [1].
[1] https://education.ki.se/student/molecular-medicine-cardiometabolic-and-infectious-diseases-15-hp/1bi048

Artiklar

Article: SCANDINAVIAN CARDIOVASCULAR JOURNAL. 2025;59(1):2513874
Aortic valve phenotype and distal aortic outcome after ascending aortic surgery
Granath C; Dismorr M; Bjoerck HM; Carlestal E; Olsson C; Bredin F
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2025;45(9):1636-1647
Tricuspid Aortic Valve Regurgitation Associates With Ascending Aortic Aneurysm Through Endothelial Activation and Lipoprotein Infiltration
Freiholtz D; Reyes-Goya C; Lang K; Bergman O; Olsson C; Granbom Koski M; Dismorr M; Osterholm C; Caidahl K; Franco-Cereceda A; Eriksson P; Gistera A; Bjorck HM
Article: HEPATOLOGY. 2025;82(1):165-183
A functional genomic framework to elucidate novel causal metabolic dysfunction-associated fatty liver disease genes
Saliba-Gustafsson P; Justesen JM; Ranta A; Sharma D; Bielczyk-Maczynska E; Li J; Najmi LA; Apodaka M; Aspichueta P; Bjorck HM; Eriksson P; Schurr TM; Franco-Cereceda A; Gloudemans M; Mujica E; den Hoed M; Assimes TL; Quertermous T; Carcamo-Orive I; Park CY; Knowles JW
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2025;14(8):e038013
Effect of Bicuspid Versus Tricuspid Aortic Valve Morphology on the Fate of the Ascending Aorta
Koski MG; Dismorr M; Bjorck HM; Olsson C; Bredin F
Article: EUROPEAN HEART JOURNAL. 2025;46(3):308-322
Atheroma transcriptomics identifies ARNTL as a smooth muscle cell regulator and with clinical and genetic data improves risk stratification
Narayanan S; Vuckovic S; Bergman O; Wirka R; Verdezoto Mosquera J; Chen QS; Baldassarre D; Tremoli E; Veglia F; Lengquist M; Aherrahrou R; Razuvaev A; Gigante B; Bjoerck HM; Miller CL; Quertermous T; Hedin U; Matic L
Article: SCIENTIFIC REPORTS. 2025;15(1):667
Fracture properties of porcine versus human thoracic aortas from tricuspid/bicuspid aortic valve patients via symmetry-constraint Compact Tension testing
Alloisio M; Siika A; Freiholtz D; Franco-Cereceda A; Roy J; Bjorck HM; Gasser TC
Article: JOURNAL OF INTERNAL MEDICINE. 2025;297(1):47-59
Statin-associated regulation of hepatic PNPLA3 in patients without known liver disease
Ahmed O; Shavva VS; Tarnawski L; Dai W; Borg F; Olofsson VV; Liu T; Saliba-Gustafsson P; Simini C; Pedrelli M; Bergman O; Norata GD; Parini P; Franco-Cereceda A; Eriksson P; Malin SG; Bjorck HM; Olofsson PS
Journal article: EUROPEAN HEART JOURNAL. 2024;45:ehae666.1861
Measures of insulin resistance and aortic valve calcification in the general population
Gottlieb AW; Gottlieb-Vedi E; Norhammar A; Gyberg V; Spaak J; Lofmark H; Lind L; Soderberg S; Bjorck H; Engstrom G; Ostgren CJ; Jernberg T; Bergstrom G; Settergren M; Shahim B
Article: EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING. 2024;25(10):1384-1393
Wall shear stress measured with 4D flow CMR correlates with biomarkers of inflammation and collagen synthesis in mild-to-moderate ascending aortic dilation and tricuspid aortic valves
Hammareus F; Trenti C; Bjorck HM; Engvall J; Lekedal H; Krzynska-Trzebiatowska A; Kylhammar D; Lindenberger M; Lundberg AK; Nilsson F; Nilsson L; Swahn E; Jonasson L; Dyverfeldt P
Article: PLOS GENETICS. 2024;20(6):e1011285
An endothelial regulatory module links blood pressure regulation with elite athletic performance
Fegraeus K; Rosengren MK; Naboulsi R; Orlando L; Abrink M; Jouni A; Velie BD; Raine A; Egner B; Mattsson CM; Lang K; Zhigulev A; Bjorck HM; Franco-Cereceda A; Eriksson P; Andersson G; Sahlen P; Meadows JRS; Lindgren G
Article: BMJ OPEN. 2024;14(3):e067977
Predictive machine learning models for ascending aortic dilatation in patients with bicuspid and tricuspid aortic valves undergoing cardiothoracic surgery: a prospective, single-centre and observational study
Gaye B; Vignac M; Gadin JR; Ladouceur M; Caidahl K; Olsson C; Franco-Cereceda A; Eriksson P; Bjorck HM
Article: NATURE CARDIOVASCULAR RESEARCH. 2024;3(3):356-371
Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
Di Nunzio G; Hellberg S; Zhang Y; Ahmed O; Wang J; Zhang X; Bjoerck HM; Chizh V; Schipper R; Aulin H; Francis R; Fagerberg L; Gistera A; Metso J; Manfe V; Franco-Cereceda A; Eriksson P; Jauhiainen M; Hagberg CE; Olofsson PS; Malin SG
Journal article: EJVES SHORT REPORTS. 2024;62:s3-s4
The Natural History of Ascending Aortic Aneurysms Involve Infiltration of Lipoproteins and Immune Cells
Freiholtz D; Bergman O; Lång K; Corbascio CÖ; Olsson C; Franco-cereceda A; Eriksson P; Gisterå A; Björck HM
Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.2030
Hemodynamics and plasma biomarkers in individuals with mild-to-moderate ascending aortic dilatation and tricuspid aortic valves
Hammareus F; Trenti C; Bjorck HM; Engvall J; Eriksson P; Lekedal H; Lundberg A; Nilsson L; Swahn E; Jonasson L; Dyverfeldt P
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2023;101(10):1323-1333
SPP1/osteopontin: a driver of fibrosis and inflammation in degenerative ascending aortic aneurysm?
Freiholtz D; Bergman O; Pradhananga S; Lang K; Poujade F-A; Granath C; Olsson C; Franco-Cereceda A; Sahlen P; Eriksson P; Bjorck HM
Article: CLINICAL PROTEOMICS. 2023;20(1):31
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Carland C; Png G; Malarstig A; Kho PF; Gustafsson S; Michaelsson K; Lind L; Tsafantakis E; Karaleftheri M; Dedoussis G; Ramisch A; Macdonald-Dunlop E; Klaric LK; Joshi P; Chen YM; Bjoerck H; Eriksson P; Carrasco-Zanini J; Wheeler E; Suhre K; Gilly A; Zeggini E; Vinuela AT; Dermitzakis EF; Wilson J; Langenberg C; Thareja G; Halama A; Schmidt F; Zanetti D; Assimes T
Journal article: ATHEROSCLEROSIS. 2023;379:s54
BICUSPID AORTIC VALVE AORTOPATHY IS CHARACTERIZED BY EMBRYONIC ENDOTHELIAL TO MESENCHYMAL TRANSITION AND ENDOTHELIAL INSTABILITY
Freiholtz D; Bergman O; Lang K; Poujade F-A; Paloschi V; Granath C; Lindeman J; Olsson C; Franco-Cereceda A; Eriksson P; Bjorck HM
Journal article: ATHEROSCLEROSIS. 2023;379:s31
POSSIBLE ROLE OF SPP1 IN DEGENERATIVE ASCENDING AORTIC ANEURYSM FORMATION
Freiholtz D; Bergman O; Poujade F-A; Granath C; Lang K; Olsson C; Franco-Cereceda A; Bjorck HM; Eriksson P
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2023;101(7):801-811
Bicuspid aortic valve aortopathy is characterized by embryonic epithelial to mesenchymal transition and endothelial instability
Freiholtz D; Bergman O; Lang K; Poujade F-A; Paloschi V; Granath C; Lindeman JHN; Olsson C; Franco-Cereceda A; Eriksson P; Bjorck HM
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023;43
A Possible Role Of Apolipoprotein B In Degenerative Ascending Aortic Aneurysm Formation And Progression
Freiholtz D; Bergman O; Corbascio CO; Lang K; Olsson C; Franco-Cereceda A; Eriksson P; Gistera A; Bjorck HM
Article: ANNALS OF THORACIC SURGERY. 2022;114(5):1665-1670
Sex Differences in Aortopathy and Valve Diseases Among Patients Undergoing Cardiac Surgical Procedure
Vignac M; Bjorck HM; Olsson C; Eriksson MJ; Jouven X; Michos ED; Franco-Cereceda A; Eriksson P; Gaye B
Journal article: ATHEROSCLEROSIS. 2022;355:37
The role of rare enhancer variants in bicuspid aortic valve pathology
Zhigulev A; Lång K; Pradhananga S; Spalinskas R; Franco-Cereceda A; Björck H; Eriksson P; Sahlén P
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2022;11(9):e024346
Acetylsalicylic Acid Is Associated With a Lower Prevalence of Ascending Aortic Aneurysm and a Decreased Aortic Expression of Cyclooxygenase 2
Granath C; Freiholtz D; Bredin F; Olsson C; Franco-Cereceda A; Bjorck HM
Article: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. 2022;61(2):388-392
Metformin therapy is not associated with the lower prevalence of ascending aortic aneurysm in diabetic patients
Vignac M; Ntika S; Olsson C; Franco-Cereceda A; Bjorck HM
Article: JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE. 2021;8(11):143
Elevated Glucagon-like Peptide-1 and a Th2 Shift May Support Reduced Prevalence of Thoracic Aortic Aneurysm in Patients with Diabetes
Ntika S; Jois H; Lang K; Olsson C; Franco-Cereceda A; Bjorck HM; Krizhanovskii C
Article: OPEN HEART. 2021;8(2):e001857
Valve disease and aortopathy associations of bicuspid aortic valve phenotypes differ between men and women
Granath C; Mohamed SA; Olsson C; Grattan M; Mertens L; Franco-Cereceda A; Bjorck HM
Article: BIOMEDICINES. 2021;9(6):697
Syndecan-1 Expression Is Increased in the Aortic Wall of Patients with Type 2 Diabetes but Is Unrelated to Elevated Fasting Plasma Glucagon-Like Peptide-1
Ntika S; Tracy LM; Franco-Cereceda A; Bjorck HM; Krizhanovskii C
Article: BIORESEARCH OPEN ACCESS. 2020;9(1):269-278
Characterization of Laminins in Healthy Human Aortic Valves and a Modified Decellularized Rat Scaffold
Granath C; Noren H; Bjorck H; Simon N; Olesen K; Rodin S; Grinnemol K-H; Osterholm C
Article: CIRCULATION RESEARCH. 2020;127(10):1261-1273
Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD
Hussain S; Khan AW; Akhmedov A; Suades R; Costantino S; Paneni F; Caidahl K; Mohammed SA; Hage C; Gkolfos C; Bjorck H; Pernow J; Lund LH; Luscher TF; Cosentino F
Article: NATURE GENETICS. 2019;51(1):42-50
ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm
Gould RA; Aziz H; Woods CE; Seman-Senderos MA; Sparks E; Preuss C; Wunnemann F; Bedja D; Moats CR; McClymont SA; Rose R; Sobreira N; Ling H; MacCarrick G; Kumar AA; Luyckx I; Cannaerts E; Verstraeten A; Bjork HM; Lehsau A-C; Jaskula-Ranga V; Lauridsen H; Shah AA; Bennett CL; Ellinor PT; Lin H; Isselbacher EM; Cardenas CLL; Butcher JT; Hughes GC; Lindsay ME; Mertens L; Franco-Cereceda A; Verhagen JMA; Wessels M; Mohamed SA; Eriksson P; Mital S; Van Laer L; Loeys BL; Andelfinger G; McCallion AS; Dietz HC; Valle D; Lupski J
Article: JOURNAL OF INTERNAL MEDICINE. 2019;285(1):102-114
The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves
Maleki S; Cottrill KA; Poujade F-A; Bhattachariya A; Bergman O; Gadin JR; Simon N; Lundstromer K; Franco-Cereceda A; Bjorck HM; Chan SY; Eriksson P
Article: BLOOD. 2018;132(17):1842-1850
DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis
Ward-Caviness CK; Huffman JE; Everett K; Germain M; van Dongen J; Hill WD; Jhun MA; Brody JA; Ghanbari M; Du L; Roetker NS; de Vries PS; Waldenberger M; Gieger C; Wolf P; Prokisch H; Koenig W; O'Donnell CJ; Levy D; Liu C; Vinh T; Wells PS; Tregouet D-A; Tang W; Morrison AC; Boerwinkle E; Wiggins KL; McKnight B; Guo X; Psaty BM; Sotoodenia N; Boomsma DI; Willemsen G; Ligthart L; Deary IJ; Zhao W; Ware EB; Kardia SLR; Van Meurs JBJ; Uitterlinden AG; Franco OH; Eriksson P; Franco-Cereceda A; Pankow JS; Johnson AD; Gagnon F; Morange P-E; de Geus EJC; Starr JM; Smith JA; Dehghan A; Bjorck HM; Smith NL; Peters A
Article: ATHEROSCLEROSIS SUPPLEMENTS. 2018;35:e6-e13
Notch, BMP and WNT/β-catenin network is impaired in endothelial cells of the patients with thoracic aortic aneurysm
Kostina A; Bjork H; Ignatieva E; Irtyuga O; Uspensky V; Semenova D; Maleki S; Tomilin A; Moiseeva O; Franco-Cereceda A; Gordeev M; Faggian G; Kostareva A; Eriksson P; Malashicheva A
Article: SCIENTIFIC REPORTS. 2018;8(1):2777
Altered DNA methylation indicates an oscillatory flow mediated epithelial-to-mesenchymal transition signature in ascending aorta of patients with bicuspid aortic valve
Bjorck HM; Du L; Pulignani S; Paloschi V; Lundstromer K; Kostina AS; Osterholm C; Malashicheva A; Kostareva A; Evangelista A; Teixido-Tura G; Maleki S; Franco-Cereceda A; Eriksson P
Article: ATHEROSCLEROSIS. 2017;266:196-204
Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
Strawbridge RJ; Silveira A; den Hoed M; Gustafsson S; Luan J; Rybin D; Dupuis J; Li-Gao R; Kavousi M; Dehghan A; Haljas K; Lahti J; Gadin JR; Backlund A; de Faire U; Gertow K; Giral P; Goel A; Humphries SE; Kurl S; Langenberg C; Lannfelt LL; Lind L; Lindgren CCM; Mannarino E; Mook-Kanamori DO; Morris AP; de Mutsert R; Rauramaa R; Saliba-Gustafsson P; Sennblad B; Smit AJ; Syvanen A-C; Tremoli E; Veglia F; Zethelius B; Bjorck HM; Eriksson JG; Hofman A; Franco OH; Watkins H; Jukema JW; Florez JC; Wareham NJ; Meigs JB; Ingelsson E; Baldassarre D; Hamsten A
Article: FRONTIERS IN PHYSIOLOGY. 2017;8:400
Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor
Gillis E; Kumar AA; Luyckx I; Preuss C; Cannaerts E; van de Beek G; Wieschendorf B; Alaerts M; Bolar N; Vandeweyer G; Meester J; Wuennemann F; Gould RA; Zhurayev R; Zerbino D; Mohamed SA; Mital S; Mertens L; Bjoerck HM; Franco-Cereceda A; McCallion AS; Van Laer L; Verhagen JMA; van de laar IMBH; Wessels MW; Messas E; Goudot G; Nemcikova M; Krebsova A; Kempers M; Salemink S; Duijnhouwer T; Jeunemaitre X; Albuisson J; Eriksson P; Andelfinger G; Dietz HC; Verstraeten A; Loeys BL
Article: SCIENTIFIC REPORTS. 2016;6:35712
Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves
Maleki S; Kjellqvist S; Paloschi V; Magne J; Branca RMM; Du L; Hultenby K; Petrini J; Fuxe J; Lehtio J; Franco-Cereceda A; Eriksson P; Bjorck HM
Article: IJC HEART AND VASCULATURE. 2016;11:74-79
Intima-media thickness of the descending aorta in patientswith bicuspid aortic valve
Petrini J; Yousry M; Eriksson P; Bjoerk HM; Rickenlund A; Franco-Cereceda A; Caidahl K; Eriksson MJ
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(suppl_1)
Abstract 500: DNA Methylation Profiling Reveals an Epithelial/Endothelial-Mesenchymal Transition-like Signature of Intima-Media Cells in the Ascending Aorta of Bicuspid Aortic Valve Patients
Björck HM; Du L; Paloschi V; Maleki S; Pulignani S; Franco-Cereceda A; Eriksson P
Article: CYTOKINE. 2016;81:1-9
Genetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease
McLeod O; Silveira A; Valdes-Marquez E; Bjorkbacka H; Almgren P; Gertow K; Gadin JR; Backlund A; Sennblad B; Baldassarre D; Veglia F; Humphries SE; Tremoli E; de Faire U; Nilsson J; Melander O; Hopewell JC; Clarke R; Bjorck HM; Hamsten A; Ohrvik J; Strawbridge RJ
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(4):973-980
Aneurysm Development in Patients With a Bicuspid Aortic Valve Is Not Associated With Transforming Growth Factor-β Activation
Paloschi V; Gadin JR; Khan S; Bjorck HM; Du L; Maleki S; Roy J; Lindeman JHM; Mohamed SA; Tsuda T; Franco-Cereceda A; Eriksson P
Article: ANNALS OF THORACIC SURGERY. 2014;98(1):65-71
Biomechanical Properties of the Thoracic Aneurysmal Wall: Differences Between Bicuspid Aortic Valve and Tricuspid Aortic Valve Patients
Forsell C; Bjorck HM; Eriksson P; Franco-Cereceda A; Gasser TC
Article: AORTA. 2013;1(1):13-22
Aneurysm Development in Patients With Bicuspid Aortic Valve (BAV): Possible Connection to Repair Deficiency?
Maleki S; Björck HM; Paloschi V; Kjellqvist S; Folkersen L; Jackson V; Franco-Cereceda A; Eriksson P
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2013;91(1):129-139
Identification of a novel flow-mediated gene expression signature in patients with bicuspid aortic valve
Maleki S; Bjorck HM; Folkersen L; Nilsson R; Renner J; Caidahl K; Franco-Cereceda A; Lanne T; Eriksson P
Article: PLOS ONE. 2012;7(12):e52227
Characterization of Shear-Sensitive Genes in the Normal Rat Aorta Identifies Hand2 as a Major Flow-Responsive Transcription Factor
Bjorck HM; Renner J; Maleki S; Nilsson SFE; Kihlberg J; Folkersen L; Karlsson M; Ebbers T; Eriksson P; Lanne T
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2011;42(3):309-316
Impaired abdominal aortic wall integrity in elderly men carrying the angiotensin-converting enzyme D allele.
Ljungberg LU; De Basso R; Alehagen U; Björck HM; Persson K; Dahlström U; Länne T
Article: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM. 2011;12(3):281-289
The association between circulating angiotensin-converting enzyme and cardiovascular risk in the elderly: a cross-sectional study.
Ljungberg L; Alehagen U; Länne T; Björck H; De Basso R; Dahlström U; Persson K
Article: AMERICAN JOURNAL OF HYPERTENSION. 2011;24(7):802-808
Gender-Specific Association of the Plasminogen Activator Inhibitor-1 4G/5G Polymorphism With Central Arterial Blood Pressure
Bjorck HM; Eriksson P; Alehagen U; De Basso R; Ljungberg LU; Persson K; Dahlstrom U; Lanne T
Journal article: ARTERY RESEARCH. 2010;4(4):162
P4.04 Impaired Abdominal Aortic Wall Integrity in Elderly Men Carrying the Angiotensin-Converting Enzyme D-Allele
Ljungberg LU; De Basso R; Alehagen U; Björck HM; Persson K; Dahlström U; Länne T
Journal article: ARTERY RESEARCH. 2009;3(4):177-178
P2.03 The Plasminogen Activator Inhibitor-1 (4G/5G) Polymorphism Affects Central Arterial Blood Pressure in Women
Björck HM; Eriksson P; Alehagen U; Ljungberg LU; DeBasso R; Persson K; Dahlström U; Länne T
Article: JOURNAL OF INTERNAL MEDICINE. 2009;265(3):373-381
Association of genetic variation on chromosome 9p21.3 and arterial stiffness
Bjorck HM; Lanne T; Alehagen U; Persson K; Rundkvist L; Hamsten A; Dahlstrom U; Eriksson P
Article: ATHEROSCLEROSIS. 2009;202(2):415-423
Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression
Wagsaeter D; Zhu C; Bjoerck HM; Eriksson P
Journal article: ARTERY RESEARCH. 2008;2(3):115-116
P2.38 The Anril Locus on Chromosome 9P21 Affects Stiffness of the Abdominal Aorta
Bjorck HM; Lanne T; Alehagen U; Persson K; Rundkvist L; Hamsten A; Dahlstrom U; Eriksson P
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Alla övriga publikationer

Preprint: MEDRXIV. 2025
Global Trends and Risk Factors of Aortic Aneurysm Mortality from 1990 to 2021: An Analysis of the Global Burden of Disease Study 2021
Câsu R-M; Metz L; Freiholtz D; Zheng X; Björck H; Zheng X
Preprint: MEDRXIV. 2025
Rare gain-of-function regulatory mutations explain the missing heritability of bicuspid aortic valve
Zhigulev A; Sjögren MP; Buyan A; Nozdrin V; Lázár E; Mauron R; Lång K; Spalinskas R; Schwochow D; Pradhananga S; Franco-Cereceda A; Lundeberg J; Kulakovskiy IV; Eriksson P; Björck HM; Sahlén P
Preprint: MEDRXIV. 2024
Lipoprotein retention and inflammation due to regurgitant blood flow as part of the natural history of degenerative ascending aortic aneurysms
Freiholtz D; Lång K; Bergman O; Olsson C; Granbom Koski M; Dismorr M; Österholm C; Caidahl K; Franco-Cereceda A; Eriksson P; Gisterå A; Björck H
Conference publication: PROCEEDINGS OF THE INTERNATIONAL SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE ... SCIENTIFIC MEETING AND EXHIBITION.. 2024
Wall Shear Stress Measured with 4D Flow MRI Correlates with Biomarkers of Inflammation and Collagen Synthesis in Aortic Dilation
Hammaréus F; Trenti C; Björck H; Engvall J; Eriksson P; Lekedal H; Lundberg A; Swahn E; Jonasson L; Nilsson L; Dyverfeldt P
Book chapter: AORTIC VALVE DISEASE - RECENT ADVANCES: CARDIOLOGY AND CARDIOVASCULAR MEDICINE. 2024;p.
Ascending Aortic Aneurysm in Relation to Aortic Valve Phenotype
Freiholtz D; Eriksson P; M. Björck H
Preprint: MEDRXIV. 2024;MEDRXIV
A functional genomic framework to elucidate novel causal non-alcoholic fatty liver disease genes.
Saliba-Gustafsson P; Justesen JM; Ranta A; Sharma D; Bielczyk-Maczynska E; Li J; Najmi LA; Apodaka M; Aspichueta P; Björck HM; Eriksson P; Franco-Cereceda A; Gloudemans M; Mujica E; den Hoed M; Assimes TL; Quertermous T; Carcamo-Orive I; Park CY; Knowles JW
Conference publication: AORTA. 2023;11(05):1-18
The Natural History of Ascending Aortic Aneurysms Involves a Site-Specific Infiltration of Lipoproteins and Immune Cells
Freiholtz D; Bergman O; Lång K; Corbascio CÖ; Olsson C; Franco-Cereceda A; Eriksson P; Gisterå A; Björck HM
Conference publication: JOURNAL OF HEPATOLOGY. 2023;78:s756-s757
Statins regulate PNPLA3 through a mechanism that requires SREBF2 in human liver cells
Ahmed O; Shavva VS; Dai W; Tarnawski L; Malin S; Franco-Cereceda A; Eriksson P; Bjorck H; Olofsson P
Preprint: RESEARCH SQUARE. 2023
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Carland C; Png G; Malarstig A; Kho PF; Gustafsson S; Michaelsson K; Lind L; Tsafantakis E; Karaleftheri M; Dedoussis G; Ramisch A; Macdonald-Dunlop E; Klaric L; Joshi PK; Chen Y; Björck HM; Eriksson P; Carrasco-Zanini J; Wheeler E; Suhre K; Gilly A; Zeggini E; Viñuela A; Dermitzakis ET; Wilson JF; Langenberg C; Thareja G; Halama A; Schmidt F; Consortium S; Zanetti D; Assimes T
Preprint: BIORXIV. 2023
The junctional mechanosensor AmotL2 regulates YAP promotor accessibility
Mannion A; Zhao H; Zhang Y; von Wright Y; Bergman O; Björck H; Saharinen P; Holmgren L
Preprint: BIORXIV. 2022
Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
Hellberg S; Ahmed O; Zhang Y; Di Nunzio G; Björck HM; Francis R; Fagerberg L; Gisterå A; Zhang X; Metso J; Manfé V; Soto Y; Franco-Cereceda A; Eriksson P; Jauhiainen M; Olofsson PS; Malin SG
Conference publication: ATHEROSCLEROSIS. 2022;355:E68-E69
THE ROLE OF RARE ENHANCER VARIANTS IN BICUSPID AORTIC VALVE PATHOLOGY
Zhigulev A; Lang K; Pradhananga S; Spalinskas R; Franco-Cereceda A; Bjorck H; Eriksson P; Sahlen P
Conference publication: AORTA. 2022;10:a1-a56
ASA is Associated with A Lower Prevalence of Ascending Aortic Aneurysm and A Decreased Aortic Expression of COX2
Granath C; Astrom DF; Bredin F; Olsson C; Franco-Cereceda A; Bjorck H
Conference publication: AORTA. 2022;10:a1-a56
Possible Role of SPP1 in Degenerative Ascending Aortic Aneurysm Formation
Bergman O; Freiholtz D; Poujade F-A; Granath C; Lång K; Ohlsson C; Franco-Cereceda A; Eriksson P; Björck H
Preprint: RESEARCH SQUARE. 2021
Clinical Classifiers to Identify Ascending Aortic Dilatation in Patients With Bicuspid Versus Tricuspid Aortic Valves
Gaye B; Vignac M; Gådin JR; Ladouceur M; Caidahl K; Olsson C; Franco-Cereceda A; Eriksson P; Björck HM
Review: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2019;6:182
Endothelial/Epithelial Mesenchymal Transition in Ascending Aortas of Patients With Bicuspid Aortic Valve
Maleki S; Poujade F-A; Bergman O; Gadin JR; Simon N; Lang K; Franco-Cereceda A; Body SC; Bjorck HM; Eriksson P
Conference publication: ATHEROSCLEROSIS. 2019;287:E287
GENDER DIFFERENCES IN PATIENTS WITH BICUSPID AORTIC VALVES
Vignac M; Gaye B; Bjorck HM; Olsson C; Franco-Cereceda A; Eriksson P
Conference publication: ATHEROSCLEROSIS. 2019;287:E277
PREDICTION OF THE DEVELOPMENT OF AORTIC DILATATION IN PATIENTS WITH BICUSPID (BAV) VERSUS TRICUSPID (TAV) AORTIC VALVES.
Gaye B; Vignac M; Bjorck HM; Olsson C; Franco-Cereceda A; Eriksson P
Conference publication: CIRCULATION. 2019;139
Prediction of the Development of Aortopathy in Patients With Bicuspid Aortic Valves
Gaye B; Bjorck HM; Ladouceur M; Vignac M; Olsson C; Cereceda AF; Eriksson P
Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S47
DNA methylation in bicuspid aortic valve aortopathy: potential contribution of oscillatory flow to an epithelial-to-mesenchymal transition signature
Bjorck H; Du L; Pulignani S; Paloschi V; Lundstromer K; Kostina A; Evangelista A; Maleki S; Franco-Cereceda A; Eriksson P
Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S83
Notch signaling pathway is attenuated in aortic endothelial cells of patients with aortic pathologies associated with bicuspid aortic valve
Kostina A; Kiselev A; Bjorck H; Irtyuga O; Sergushichev A; Baranov Y; Eriksson P; Kostareva A; Malashicheva A
Corrigendum: FRONTIERS IN PHYSIOLOGY. 2017;8:730
Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor (vol 8, pg 400, 2017)
Gillis E; Kumar AA; Luyckx I; Preuss C; Cannaerts E; van de Beek G; Wieschendorf B; Alaerts M; Bolar N; Vandeweyer G; Meester J; Wunnemann F; Gould RA; Zhurayev R; Zerbino D; Mohamed SA; Mital S; Mertens L; Bjorck HM; Franco-Cereceda A; McCallion AS; Van Laer L; Verhagen JMA; van de Laar IMBH; Wessels MW; Messas E; Goudot G; Nemcikova M; Krebsova A; Kempers M; Salemink S; Dufinhouwer T; Jeunemaitre X; Albuisson J; Eriksson P; Andelfinger G; Dietz HC; Verstraeten A; Loeys BL
Conference publication: CARDIOVASCULAR RESEARCH. 2016;111:S104
Role of non-coding RNAs in thoracic aortic aneurysm associated with bicuspid aortic valve
Bhattachariya A; Cottrill KA; Du L; Bjorck HM; Maleki S; Franco-Cereceda A; Chan SY; Eriksson P
Conference publication: JOURNAL OF VASCULAR RESEARCH. 2015;52:26
EPIGENETIC CHANGES ASSOCIATED WITH BICUSPID- AND TRICUSPID AORTIC VALVE ANEURYSMS
Bjorck HM; Du L; Paloschi V; Pulignani S; Maleki S; Franco-Cereceda A; Eriksson P
Conference publication: JOURNAL OF VASCULAR RESEARCH. 2015;52:46-47
ANEURYSM DEVELOPMENT IN PATIENTS WITH A BICUSPID AORTIC VALVE IS NOT ASSOCIATED WITH TRANSFORMING GROWTH FACTOR-? ACTIVATION
Paloschi V; Gadin RJ; Bjorck HM; Maleki S; Du L; Franco-cereceda A; Eriksson P
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):60
PDGF-C AND PDGF-D IN ATHEROSCLEROSIS
Wagsater D; Bjorck H; Zhu C; Eriksson P
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Thorakalt aortaaneurysm och associerad hjärtklaffsjukdom - molekylära mekanismer och klinisk prognos
Prins Daniels forskningsanslag för yngre lovande forskare, Hjärtlungfonden
1 January 2025 - 31 December 2027
Thorakalt aortaaneurysm och associerad hjärtklaffsjukdom - molekylära och genetiska mekanismer och klinisk prognos.
Hjärtlungfonden Forskartjänst
1 January 2025 - 31 December 2030
Aortic valve disease and associated thoracic aortic aneurysm
Swedish Research Council
1 January 2021 - 31 December 2023
THORACIC AORTIC ANEURYSM PATHOLOGY
Swedish Heart-Lung Foundation
1 January 2019 - 31 December 2021
Molecular aspects of thoracic aortic aneurysm pathology
Swedish Research Council
1 January 2017 - 31 December 2020

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