Giulia Grande

Giulia Grande

Biträdande Lektor
E-postadress: giulia.grande@ki.se
Besöksadress: Tomtebodavägen 18 A, 17177 Solna
Postadress: H1 Neurobiologi, vårdvetenskap och samhälle, H1 ARC Medicin Rizzuto, 171 77 Stockholm
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Forskningsbidrag

  • Swedish Research Council for Health Working Life and Welfare
    1 January 2023 - 31 December 2025
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2023 - 31 December 2026
    Research problem and specific questions. Traffic noise is an environmental exposure of growing concern with mounting evidence of serious adverse health effects. At least one in five Europeans (approximately 113 million people) are exposed to noise levels exceeding the European Environment Agency indicator level linked to harmful health effects. Besides the increased risk of cardiovascular and metabolic effects, hearing loss, and sleep disturbance, more recent studies have indicated that prolonged exposure to noise might accelerate the risk of cognitive impairment, degenerative dementia, anxiety, and depression.  Data and Methods. We take advantage of the pre-existing data within the Nordic Studies on Occupational and Traffic Noise in Relation to Disease (NordSOUND) project, comprising over 185 000 adults from five Swedish and two Danish cohorts, to investigate whether exposure to traffic and occupational noise is related to dementia and mental health (depression, and anxiety) and to reveal potential mechanisms. We will adjust for individual- and area-level covariates to enable increased precision in the assessment of associations. We will also adjust for residential air pollution exposure and lack of greenness to explore the potential interactions.  Plan for project realization. The research group involved in the project is multidisciplinary, and the complementary expertise of the team members will guarantee a broad perspective considering clinical, social, and public health relevance as well as adequate methodological and management skills. A postdoc research fellow will implement the study plan, coordinated and supervised by project leader and senior researchers. Relevance. This collaborative research effort will address a considerable knowledge gap regarding noise exposure, dementia and mental health. Our results may have significant implications for risk assessment and public health policy, especially considering the recently relaxed noise guidelines in Sweden and the rapid urban growth.
  • Swedish Research Council
    1 January 2022 - 31 December 2024
  • Swedish Research Council
    1 December 2021 - 30 November 2025
  • Swedish Research Council for Health Working Life and Welfare
    1 November 2021 - 31 October 2026
    Dementia is one of the major causes of disability and dependence and its impact on healthcare systems leads to an enormous burden on our current and future society. The goal of this project is to provide evidence supporting timely and personalized care for people with cognitive disorders (mild cognitive impairment [MCI] and dementia). Specifically, we aim to 1) Explore care needs and care utilization in people with MCI and dementia and capture their changes depending on disease progression, comorbidities, and social context, 2) Compare dementia cases diagnosed at specialized settings with undiagnosed cases (identified in population-based cohort studies) to detect potentially different care trajectories, 3) Map the 30-year secular trend of care use and institutionalization in people with dementia from the 1990s to 2020s in Sweden (urban and rural areas), and 4) Develop a predictive model to provide an updated estimate of the number of people with MCI and dementia given decreasing dementia incidence and increasing survival, and to identify who will need home assistance or institutionalization and when. To address these aims, we rely on the expertise of a multidisciplinary team, and high-quality data from three population-based cohorts studies and a national quality registry: the Kungsholmen Project (KP, n=1810 aged ≥75, 1987-2000), the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K, n=3363 aged ≥60, 2001-2021) and Nordanstig (SNAC-N, n=766 aged ≥60, 2001-2021), and the Swedish Dementia Registry (SveDem, n=100133, 2007-2021). In these datasets, MCI and dementia were diagnosed using standard criteria, and data on the quantity and quality of formal (home and institution) and informal care were collected. Information on contextual factors and medical conditions is available. Findings from this project will provide practical information for healthcare managers to plan and deliver tailored and stage-specific care to people with cognitive disorders.

Anställningar

  • Biträdande Lektor, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2024-2030

Examina och utbildning

  • Medicine Doktorsexamen, Institutionen för neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2020

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