Giulia Grande

Giulia Grande

Assistant Professor
Visiting address: Tomtebodavägen 18 A, 17177 Solna
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 ARC Medicin Rizzuto, 171 77 Stockholm
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About me

  • Giulia Grande is a specialized neurologist who completed her medical degree and residency at the University of Milan, Italy.
    In 2020, she obtained her Ph.D. in geriatric epidemiology at Karolinska Institutet, focusing on the connection between the body and mind in the development of dementia among older adults.

Research

  • Giulia Grande's primary research interests encompass:
    - Somatic Contribution to Dementia Onset: Investigating the impact of various chronic conditions on accelerating cognitive decline and the development of dementia.
    - Blood-Based Biomarkers of Alzheimer's Disease: Exploring the role of blood-based biomarkers in predicting dementia within a population setting.
    - Biological Mechanisms of Air Pollution and Dementia: Studying the biological mechanisms that link long-term exposure to air pollution with dementia.
    Additionally, Giulia has received a grant as principal investigator from the Swedish Research Council for Health, Working Life, and Welfare (FORTE) project with the aim to explore intergenerational differences in cognitive trajectories among Swedish older adults.


    Giulia´s most relevant publications:
    1. Valletta M, Vetrano DL, Calderón-Larrañaga A, Kalpouzos G, Canevelli M, Marengoni A, Laukka EJ, Grande G. Association of mild and complex multimorbidity with structural brain changes in older adults: a population-based study. Alzheimers Dement. 2024
    2. Grande G, Hooshmand B, Vetrano DL, Smith DA, Refsum H, Fratiglioni L, Ljungman P, Wu J, Bellavia A, Eneroth K, Bellander T, Rizzuto D. Association of Long-term Exposure to Air Pollution and Dementia Risk: The Role of Homocysteine, Methionine, and Cardiovascular Burden. Neurology. 2023 Sep 19
  • 101(12):e1231-e1240.
    3. Valletta M, Vetrano DL, Xia X, Rizzuto D, Roso-Llorach A, Calderón-Larrañaga A, Marengoni A, Laukka EJ, Canevelli M, Bruno G, Fratiglioni L, Grande G. Multimorbidity patterns and 18-year transitions from normal cognition to dementia and death: A population-based study. J Intern Med. 2023 Sep
  • 294(3):326-335
    4. Grande G, Marengoni A, Vetrano DL, Roso-Llorach A, Rizzuto D, Zucchelli A, Qiu C, Fratiglioni L, Calderón-Larrañaga A. Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics. Alzheimers Dement. 2021 Jan 6. doi: 10.1002/alz.12237. Online ahead of print.PMID: 33403740
    5. Grande G, Ljungman PLS, Eneroth K, Bellander T, Rizzuto D. Association between cardiovascular disease and long-term exposure to air pollution with the risk of dementia. JAMA Neurol. 2020 Jul 1
  • 77(7):801-809. doi:10.1001/jamaneurol.2019.4914. PMID: 32227140
    6. Grande G, Qiu C, Fratiglioni L. Prevention of dementia in an ageing world: Evidence and biological rationale. Ageing Res Rev. 2020 Mar 19:101045. doi: 10.1016/j.arr.2020.101045. Online ahead of print.PMID: 32171784 Review.
    7. Grande G, Rizzuto D, Vetrano DL, Marseglia A, Vanacore N, Laukka EJ, Welmer AK, Fratiglioni L. Cognitive and physical markers of prodromal demenia: a 12-year-long population study. Alzheimers Dement. 2020 Jan
  • 16(1):153-161. doi: 10.1002/alz.12002. PMID: 31914224
    8. Grande G, Haaksma ML, Rizzuto D, Melis RJF, Marengoni A, Onder G, Welmer AK, Fratiglioni L, Vetrano DL. Co-occurrence of cognitive impairment and physical frailty, and incidence of dementia: systematic review and meta-analysis. Neurosci Biobehav Rev. 2019 Sep 3. pii: S0149-7634(18)30938-2. doi:10.1016/j.neubiorev.2019.09.001. [Epub ahead of print] Review. PubMed PMID:31491474.
    9. Grande G, Triolo F, Nuara A, Welmer AK, Fratiglioni L, Vetrano DL. Measuring gait speed to better identify prodromal dementia. Exp Gerontol. 2019 Sep
  • 124:110625.

Teaching

  • Giulia actively engages in pedagogical activities, including supervising Ph.D. students as both co-supervisor and main supervisor, international guest, master's, and undergraduate students, and co-leading a master course in geriatric epidemiology and a doctoral course in epidemiology.

Articles

All other publications

  • Review: AGEING RESEARCH REVIEWS. 2023;91:102039
    Tazzeo C; Zucchelli A; Vetrano DL; Demurtas J; Smith L; Schoene D; Sanchez-Rodriguez D; Onder G; Balci C; Bonetti S; Grande G; Torbahn G; Veronese N; Marengoni A
  • Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):716
    de Rojas I; Moreno-Grau S; Tesi N; Grenier-Boley B; Andrade V; Jansen I; Pedersen NL; Stringa N; Zettergren A; Hernandez I; Montrreal L; Antunez C; Antonell A; Tankard RM; Bis J; Sims R; Bellenguez C; Quintela I; Gonzalez-Perez A; Calero M; Franco-Macias E; Macias J; Blesa R; Cervera-Carles L; Menendez-Gonzalez M; Frank-Garcia AC; Royo JLW; Moreno F; Huerto Vilas R; Baquero M; Diez-Fairen M; Lage C; Garcia-Madrona S; Garcia-Gonzalez P; Alarcon-Martin E; Valero S; Sotolongo-Grau O; Ullgren A; Naj AC; Lemstra AW; Benaque A; Perez-Cordon A; Benussi AL; Rabano A; Padovani A; Squassina A; de Mendonca A; Arias Pastor AM; Kok AAL; Meggy A; Pastor AB; Espinosa A; Corma-Gomez A; Martin Montes A; Sanabria A; DeStefano AW; Schneider A; Haapasalo A; Kinhult Stahlbom A; Tybjaerg-Hansen A; Hartmann AM; Spottke A; Corbaton-Anchuelo A; Rongve AB; Borroni B; Arosio B; Nacmias B; Nordestgaard BG; Kunkle BW; Charbonnier C; Abdelnour C; Masullo C; Martinez Rodriguez C; Munoz-Fernandez C; Dufouil C; Graff C; Ferreira C; Chillotti C; Reynolds CA; Fenoglio C; Van Broeckhoven C; Clark C; Pisanu C; Satizabal CL; Holmes C; Buiza-Rueda D; Aarsland D; Rujescu D; Alcolea D; Galimberti D; Wallon D; Seripa D; Grunblatt E; Dardiotis E; Duezel E; Scarpini E; Conti E; Rubino E; Gelpi E; Rodriguez-Rodriguez E; Duron E; Boerwinkle E; Ferri E; Tagliavini F; Kuecuekali F; Pasquier F; Sanchez-Garcia F; Mangialasche F; Jessen F; Nicolas G; Selbaek G; Ortega GK; Chene G; Hadjigeorgiou G; Rossi G; Spalletta G; Giaccone G; Grande G; Binetti G; Papenberg G; Hampel H; Bailly H; Zetterberg H; Soininen H; Karlsson I; Alvarez I; Appollonio I; Giegling I; Skoog I; Saltvedt I; Rainero I; Rosas Allende I; Hort J; Diehl-Schmid J; Van Dongen J; Vidal J-S; Lehtisalo J; Wiltfang J; Thomassen JQ; Kornhuber J; Haines JA; Vogelgsang J; Pineda J; Fortea J; Popp J; Deckert J; Buerger K; Morgan K; Fliessbach K; Sleegers K; Molina-Porcel L; Kilander L; Weinhold L; Farrer L; Wang L-S; Kleineidam L; Farotti LA; Parnetti L; Tremolizzo L; Hausner L; Benussi L; Froelich L; Ikram MA; Deniz-Naranjo MC; Tsolaki M; Rosende-Roca M; Lowenmark M; Hulsman M; Spallazzi M; Pericak-Vance MH; Esiri M; Bernal Sanchez-Arjona M; Dalmasso MC; Martinez-Larrad MTT; Arcaro M; Noethen M; Fernandez-Fuertes M; Dichgans M; Ingelsson M; Herrmann M; Scherer M; Vyhnalek M; Kosmidis MM; Yannakoulia MM; Schmid M; Ewers MJ; Heneka MT; Wagner M; Scamosci M; Kivipelto M; Hiltunen M; Zulaica M; Alegret M; Fornage M; Roberto N; van Schoor N; Seidu N; Banaj N; Armstrong N; Scarmeas N; Scherbaum NA; Goldhardt O; Hanon O; Peters O; Skrobot OA; Quenez O; Lerch O; Bossu P; Caffarra P; Dionigi Rossi P; Sakka P; Mecocci P; Hoffmann P; Holmans P; Fischer PA; Riederer P; Yang Q; Marshall R; Kalaria RN; Mayeux R; Vandenberghe R; Cecchetti R; Ghidoni R; Frikke-Schmidt R; Sorbi S; Haegg S; Engelborghs S; Helisalmi S; Botne Sando S; Kern S; Archetti S; Boschi S; Fostinelli S; Gil S; Mendoza S; Mead S; Ciccone S; Djurovic S; Heilmann-Heimbach S; Riedel-Heller S; Kuulasmaa T; del Ser T; Lebouvier T; Polak T; Ngandu T; Grimmer T; Bessi V; Escott-Price V; Giedraitis V; Deramecourt V; Maier W; Jian X; Pijnenburg YAL; Kehoe PG; Garcia-Ribas G; Sanchez-Juan P; Pastor P; Perez-Tur J; Pinol-Ripoll G; De Munain AL; Garcia-Alberca JM; Bullido MJ; Alvarez V; Lleo A; Real LM; Medina PMM; Scheltens P; Holstege H; Marquie M; Saez ME; Carracedo A; Amouyel P; Schellenberg GD; Williams J; Seshadri S; Van Duijn C; Mather KA; Sanchez-Valle R; Serrano-Rios M; Orellana A; Tarraga L; Blennow K; Andreassen OA; Posthuma D; Clarimon J; Boada M; Van der Flier WM; Ramirez A; Lambert J-C; Van der Lee SJ; Ruiz A
  • Letter: JAMA NEUROLOGY. 2020;77(12):1581-1582
    Rizzuto D; Grande G; Bellavia A
  • Review: AGEING RESEARCH REVIEWS. 2020;64:101045
    Grande G; Qiu C; Fratiglioni L
  • Thesis / dissertation: 2020
    Grande, Giulia
  • Review: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2020;21(10):1415-1422.e6
    Demurtas J; Schoene D; Torbahn G; Marengoni A; Grande G; Zou L; Petrovic M; Maggi S; Cesari M; Lamb S; Soysal P; Kemmler W; Sieber C; Mueller C; Shenkin SD; Schwingshackl L; Smith L; Veronese N
  • Review: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2019;107:96-103
    Grande G; Haaksma ML; Rizzuto D; Melis RJF; Marengoni A; Onder G; Welmer A-K; Fratiglioni L; Vetrano DL
  • Review: EXPERIMENTAL GERONTOLOGY. 2019;124:110625
    Grande G; Triolo F; Nuara A; Welmer A-K; Fratiglioni L; Vetrano DL
  • Review: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2019;101:122-128
    Canevelli M; Bruno G; Grande G; Quarata F; Raganato R; Remiddi F; Valletta M; Zaccaria V; Vanacore N; Cesari M

Grants

Employments

  • Assistant Professor, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2024-2028

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2020

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