Giulia Grande
Assistant Professor
E-mail: giulia.grande@ki.se
Visiting address: Tomtebodavägen 18 A, 17177 Solna
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 ARC Medicin Rizzuto, 171 77 Stockholm
About me
- Giulia Grande is a specialized neurologist who completed her medical degree and residency at the University of Milan, Italy.
In 2020, she obtained her Ph.D. in geriatric epidemiology at Karolinska Institutet, focusing on the connection between the body and mind in the development of dementia among older adults.
Research
- Giulia Grande's primary research interests encompass:
- Somatic Contribution to Dementia Onset: Investigating the impact of various chronic conditions on accelerating cognitive decline and the development of dementia.
- Blood-Based Biomarkers of Alzheimer's Disease: Exploring the role of blood-based biomarkers in predicting dementia within a population setting.
- Biological Mechanisms of Air Pollution and Dementia: Studying the biological mechanisms that link long-term exposure to air pollution with dementia.
Additionally, Giulia has received a grant as principal investigator from the Swedish Research Council for Health, Working Life, and Welfare (FORTE) project with the aim to explore intergenerational differences in cognitive trajectories among Swedish older adults.
Giulia´s most relevant publications:
1. Valletta M, Vetrano DL, Calderón-Larrañaga A, Kalpouzos G, Canevelli M, Marengoni A, Laukka EJ, Grande G. Association of mild and complex multimorbidity with structural brain changes in older adults: a population-based study. Alzheimers Dement. 2024
2. Grande G, Hooshmand B, Vetrano DL, Smith DA, Refsum H, Fratiglioni L, Ljungman P, Wu J, Bellavia A, Eneroth K, Bellander T, Rizzuto D. Association of Long-term Exposure to Air Pollution and Dementia Risk: The Role of Homocysteine, Methionine, and Cardiovascular Burden. Neurology. 2023 Sep 19 - 101(12):e1231-e1240.
3. Valletta M, Vetrano DL, Xia X, Rizzuto D, Roso-Llorach A, Calderón-Larrañaga A, Marengoni A, Laukka EJ, Canevelli M, Bruno G, Fratiglioni L, Grande G. Multimorbidity patterns and 18-year transitions from normal cognition to dementia and death: A population-based study. J Intern Med. 2023 Sep - 294(3):326-335
4. Grande G, Marengoni A, Vetrano DL, Roso-Llorach A, Rizzuto D, Zucchelli A, Qiu C, Fratiglioni L, Calderón-Larrañaga A. Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics. Alzheimers Dement. 2021 Jan 6. doi: 10.1002/alz.12237. Online ahead of print.PMID: 33403740
5. Grande G, Ljungman PLS, Eneroth K, Bellander T, Rizzuto D. Association between cardiovascular disease and long-term exposure to air pollution with the risk of dementia. JAMA Neurol. 2020 Jul 1 - 77(7):801-809. doi:10.1001/jamaneurol.2019.4914. PMID: 32227140
6. Grande G, Qiu C, Fratiglioni L. Prevention of dementia in an ageing world: Evidence and biological rationale. Ageing Res Rev. 2020 Mar 19:101045. doi: 10.1016/j.arr.2020.101045. Online ahead of print.PMID: 32171784 Review.
7. Grande G, Rizzuto D, Vetrano DL, Marseglia A, Vanacore N, Laukka EJ, Welmer AK, Fratiglioni L. Cognitive and physical markers of prodromal demenia: a 12-year-long population study. Alzheimers Dement. 2020 Jan - 16(1):153-161. doi: 10.1002/alz.12002. PMID: 31914224
8. Grande G, Haaksma ML, Rizzuto D, Melis RJF, Marengoni A, Onder G, Welmer AK, Fratiglioni L, Vetrano DL. Co-occurrence of cognitive impairment and physical frailty, and incidence of dementia: systematic review and meta-analysis. Neurosci Biobehav Rev. 2019 Sep 3. pii: S0149-7634(18)30938-2. doi:10.1016/j.neubiorev.2019.09.001. [Epub ahead of print] Review. PubMed PMID:31491474.
9. Grande G, Triolo F, Nuara A, Welmer AK, Fratiglioni L, Vetrano DL. Measuring gait speed to better identify prodromal dementia. Exp Gerontol. 2019 Sep - 124:110625.
Teaching
- Giulia actively engages in pedagogical activities, including supervising Ph.D. students as both co-supervisor and main supervisor, international guest, master's, and undergraduate students, and co-leading a master course in geriatric epidemiology and a doctoral course in epidemiology.
Articles
- Article: ALZHEIMER'S AND DEMENTIA. 2024;20(6):4115-4125
- Article: THE LANCET. HEALTHY LONGEVITY. 2024;5(5):e356-e369
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2024;79(4):glae010
- Article: ALZHEIMER'S AND DEMENTIA. 2024;20(3):1958-1965
- Article: ENVIRONMENT INTERNATIONAL. 2024;185:108572
- Article: NEUROPSYCHOLOGY. 2024;38(3):211-222
- Article: ALZHEIMER'S AND DEMENTIA. 2023;19(12):5541-5549
- Article: ENVIRONMENTAL POLLUTION. 2023;336:122394
- Article: NEUROLOGY. 2023;101(12):e1231-e1240
- Article: JOURNAL OF INTERNAL MEDICINE. 2023;294(3):326-335
- Article: JOURNAL OF CLINICAL PSYCHIATRY. 2023;84(5):22m14565
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;78(8):1453-1460
- Article: JOURNAL OF INTERNAL MEDICINE. 2023;294(2):191-202
- Article: ALZHEIMER'S AND DEMENTIA. 2023;19(7):3244-3249
- Article: ALZHEIMER'S AND DEMENTIA. 2023;19(7):3019-3027
- Article: HYPERTENSION. 2023;80(7):1474-1483
- Article: ALZHEIMER'S AND DEMENTIA. 2023;19(3):821-830
- Article: ALZHEIMER'S AND DEMENTIA. 2023;19(3):857-867
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;78(2):326-332
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;78(1):143-150
- Article: ALZHEIMER'S AND DEMENTIA. 2023;19(1):56-66
- Article: PSYCHIATRY RESEARCH - NEUROIMAGING. 2022;326:111542
- Article: NEUROLOGICAL SCIENCES. 2022;43(10):5899-5908
- Article: ALZHEIMER'S AND DEMENTIA. 2022;18(10):1779-1787
- Article: JOURNAL OF ALZHEIMER'S DISEASE. 2022;88(1):263-271
- Article: CURRENT MEDICAL RESEARCH AND OPINION. 2022;38(5):743-747
- Article: NATURE GENETICS. 2022;54(4):412-436
- Article: ENVIRONMENT INTERNATIONAL. 2022;160:107067
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2022;130(2):27005
- Article: ALZHEIMER'S AND DEMENTIA. 2021;17(11):1769-1778
- Article: HYPERTENSION. 2021;78(3):769-778
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2021;76(9):E163-E170
- Article: NATURE COMMUNICATIONS. 2021;12(1):3417
- Article: ALZHEIMER'S AND DEMENTIA. 2021;17(5):768-776
- Article: JOURNAL OF ALZHEIMER'S DISEASE. 2021;80(2):591-599
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2021;76(1):157-163
- Article: ALZHEIMER'S AND DEMENTIA. 2020;16(11):1534-1543
- Article: AGE AND AGEING. 2020;49(6):923-926
- Article: JOURNAL OF ALZHEIMER'S DISEASE. 2020;77(4):1443-1453
- Article: JAMA NEUROLOGY. 2020;77(7):801-809
- Article: JOURNAL OF WOMEN'S HEALTH. 2020;29(7):927-936
- Article: AGING CLINICAL AND EXPERIMENTAL RESEARCH. 2020;32(6):1007-1016
- Article: ALZHEIMER'S AND DEMENTIA. 2020;16(5):770-778
- Article: AGING. 2020;12(4):3730-3746
- Article: JAMA NETWORK OPEN. 2020;3(2):e1921636
- Article: JOURNAL OF HOSPICE AND PALLIATIVE NURSING. 2020;22(1):75-81
- Article: ALZHEIMER'S AND DEMENTIA. 2020;16(1):153-161
- Article: AGE AND AGEING. 2019;48(6):789-796
- Article: BMC MEDICINE. 2019;17(1):185
- Article: NEUROLOGICAL SCIENCES. 2018;39(11):1867-1875
- Article: EUROPEAN JOURNAL OF INTERNAL MEDICINE. 2018;56:53-56
- Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2018;19(8):710-713
- Article: DRUGS AND AGING. 2017;34(7):529-533
- Article: EUROPEAN JOURNAL OF NEUROLOGY. 2017;24(7):950-955
- Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2017;18(6):551.e1-551.e7
- Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2016;17(11):1056-1059
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All other publications
- Review: AGEING RESEARCH REVIEWS. 2023;91:102039
- Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):716
- Letter: JAMA NEUROLOGY. 2020;77(12):1581-1582
- Review: AGEING RESEARCH REVIEWS. 2020;64:101045
- Thesis / dissertation: 2020
- Review: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2020;21(10):1415-1422.e6
- Review: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2019;107:96-103
- Review: EXPERIMENTAL GERONTOLOGY. 2019;124:110625
- Review: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2019;101:122-128
Grants
- Swedish Research Council for Health Working Life and Welfare1 January 2023 - 31 December 2024
- Swedish Research Council for Health Working Life and Welfare1 January 2023 - 31 December 2025
- Swedish Research Council1 January 2022 - 31 December 2024
- Swedish Research Council1 December 2021 - 30 November 2025
- Swedish Research Council for Health Working Life and Welfare1 November 2021 - 31 October 2025
Employments
- Assistant Professor, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2024-2028
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2020