Gianluigi Pironti

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Journal article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2026;11(8):101635
The Orally Available Ghrelin Receptor-Agonist AC01 Improves Systolic Function in HFrEF Mice and Nonhuman Primates
Lund LH; Hage C; Carlstrom M; Champeroux P; Stahlberg M; Stromberg P; Westerberg G; Lovati E; Gordon A; Sjodahl J; Andersson DC; Pironti G
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2026;399(9):13437-13443
Post-prandial acyl ghrelin infusion in heart failure patients increases gastric emptying rate
Webb D-L; Hage C; Ljung-Faxen U; Pironti G; Thorvaldsen T; Andersson DC; Stahlberg M; Lund LH; Hellstrom PM
Article: ANTIOXIDANTS. 2026;15(1):58
Targeting Arginase 1 but Not Arginase 2 Protects from Myocardial Ischemia-Reperfusion Injury via Nitric Oxide Signaling by Red Blood Cells in Type 2 Diabetes
Yang J; Tratsiakovich Y; Cao R; Mahdi A; Pironti G; Jiao T; Humoud R; Kontidou E; Tengbom J; Collado A; Zhou Z; Cao Y; Kohler E; Mullick AE; Pernow J
Article: ACTA PHYSIOLOGICA. 2025;241(11):e70115
Dietary Nitrate Prevents Cardiac Dysfunction in HFrEF by Improving Hemodynamics, Ameliorating Remodeling, and Resolving Inflammation
Shimari M; Picozzi G; Boeder A; Guimaraes DD; Zhuge Z; Lundberg JO; Carlstrom M; Lund LH; Andersson DC; Pironti G
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2024;327(5):H1257-H1271
USP20 deletion promotes eccentric cardiac remodeling in response to pressure overload and increases mortality
Jean-Charles P-Y; Roy B; Yu SM-W; Pironti G; Nagi K; Mao L; Kaur S; Abraham DM; Maudsley S; Rockman HA; Shenoy SK
Article: LAB ANIMAL. 2024;53(11):336-346
A novel model of cardiovascular-kidney-metabolic syndrome combining unilateral nephrectomy and high-salt-sugar-fat diet in mice
Carvalho LRRA; Shimari M; Boeder AM; Zhuge Z; Cai M; Leijding C; Gastaldello S; Kleschyov AL; Schiffer TA; Guimaraes DD; Picozzi G; Lund LH; Fellstrom B; Weitzberg E; Lundberg JO; Hagberg CE; Pironti G; Andersson DC; Carlstrom M
Journal article: EUROPEAN HEART JOURNAL. 2024;45:ehae666.3757
The ghrelin receptor agonist AC01 improves cardiac function in non-human primates and in mice with heart failure by increasing cardiomyocyte contractility
Pironti G; Hage C; Carlstrom M; Champeroux P; Stahlberg M; Stromberg P; Lovati E; Andersson DC; Lund LH
Article: ESC HEART FAILURE. 2024;11(1):601-605
Acyl ghrelin increases cardiac output while preserving right ventricular-pulmonary arterial coupling in heart failure
Erhardsson M; Faxen UL; Venkateshvaran A; Hage C; Pironti G; Thorvaldsen T; Webb D-L; Hellstroem PM; Andersson DC; Stahlberg M; Lund LH
Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.760
Acyl ghrelin increases cardiac output and preserves right ventricular-pulmonary arterial coupling in patients with heart failure
Erhardsson M; Faxen UL; Venkateshvaran A; Hage C; Pironti G; Thorvaldsson T; Shahgaldi K; Webb DL; Hellstrom P; Andersson DC; Stalhberg M; Lund L
Article: EUROPEAN HEART JOURNAL. 2023;44(22):2009-2025
Acyl ghrelin improves cardiac function in heart failure and increases fractional shortening in cardiomyocytes without calcium mobilization
Lund LH; Hage C; Pironti G; Thorvaldsen T; Ljung-Faxen U; Zabarovskaja S; Shahgaldi K; Webb D-L; Hellstrom PM; Andersson DC; Stahlberg M
Article: ACTA PHYSIOLOGICA. 2022;236(3):e13869
Citrullination is linked to reduced Ca²⁺ sensitivity in hearts of a murine model of rheumatoid arthritis
Pironti G; Gastaldello S; Rassier DE; Lanner JT; Carlstrom M; Lund LH; Westerblad H; Yamada T; Andersson DC
Article: FASEB JOURNAL. 2021;35(12):e22010
Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force
Liu Z; Chaillou T; Santos Alves E; Mader T; Jude B; Ferreira DMS; Hynynen H; Cheng AJ; Jonsson WO; Pironti G; Andersson DC; Kenne E; Ruas JL; Tavi P; Lanner JT
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;9:640723
Mechanistic and Therapeutic Implications of Extracellular Vesicles as a Potential Link Between Covid-19 and Cardiovascular Disease Manifestations
Pironti G; Andersson DC; Lund LH
Article: CARDIOVASCULAR RESEARCH. 2020;116(3):619-632
Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring
Manti M; Fornes R; Pironti G; Haworth SM; Zhengbing Z; Benrick A; Carlstrom M; Andersson D; Stener-Victorin E
Journal article: JOURNAL OF THE ENDOCRINE SOCIETY. 2019;3(Supplement_1):mon-217
MON-217 Maternal Androgen Excess and Obesity Induce Cardiac Hypertrophy and Left Ventricular Dysfunction in Female Offspring
Manti M; Fornes R; Pironti G; Haworth SM; Zhuge Z; Hirschberg AL; De Castro Barbosa T; Benrick A; Carlström M; Andersson D; Stener-Victorin E
Article: HEART. 2018;104(24):2026-2034
Cardiomyopathy, oxidative stress and impaired contractility in a rheumatoid arthritis mouse model
Pironti G; Bersellini-Farinotti A; Agalave NM; Sandor K; Fernandez-Zafra T; Jurczak A; Lund LH; Svensson CI; Andersson DC
Article: HYPERTENSION. 2018;71(3):507-517
Akap1 Regulates Vascular Function and Endothelial Cells Behavior
Schiattarella GG; Cattaneo F; Carrizzo A; Paolillo R; Boccella N; Ambrosio M; Damato A; Pironti G; Franzone A; Russo G; Magliulo F; Pirozzi M; Storto M; Madonna M; Gargiulo G; Trimarco V; Rinaldi L; De Lucia M; Garbi C; Feliciello A; Esposito G; Vecchione C; Perrino C
Article: PLOS ONE. 2016;11(5):e0154076
Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis
Schiattarella GG; Cattaneo F; Pironti G; Magliulo F; Carotenuto G; Pirozzi M; Polishchuk R; Borzacchiello D; Paolillo R; Oliveti M; Boccella N; Avvedimento M; Sepe M; Lombardi A; Busiello RA; Trimarco B; Esposito G; Feliciello A; Perrino C
Article: BASIC RESEARCH IN CARDIOLOGY. 2016;111(3):34
Dietary nitrate improves cardiac contractility via enhanced cellular Ca²⁺ signaling
Pironti G; Ivarsson N; Yang J; Farinotti AB; Jonsson W; Zhang S-J; Bas D; Svensson CI; Westerblad H; Weitzberg E; Lundberg JO; Pernow J; Lanner J; Andersson DC
Article: SCIENCE TRANSLATIONAL MEDICINE. 2015;7(319):319ra207
Pacemaker-induced transient asynchrony suppresses heart failure progression
Kirk JA; Chakir K; Lee KH; Karst E; Holewinski RJ; Pironti G; Tunin RS; Pozios I; Abraham TP; de Tombe P; Rockman HA; Van Eyk JE; Craig R; Farazi TG; Kass DA
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Alla övriga publikationer

Preprint: BIORXIV. 2026;BIORXIV
MitoSAM-dependent lipoylation controls postnatal heart development via metabolic remodeling.
Rumyantseva A; Wilhalm A; Carter W; Tippetts TS; Moedas M; Rosenberger FA; Moore D; Végvári Á; Hinze Y; Muellner-Wong L; Alsina D; Wibom R; Winston R; Mathews TP; Lund LH; Andersson DC; Pironti G; Wedell A; DeBerardinis RJ; Freyer C; Wredenberg A
Review: MED. 2026;:101073
Emerging therapeutic directions for inotropic therapy in heart failure.
Pironti G; Maack C; Andersson DC; Lund LH
Letter: CARDIOVASCULAR RESEARCH. 2026;122(1):10-13
The ghrelin receptor agonist AC01 improves cardiomyocyte contractility through Gα_i signalling and without Ca²⁺ mobilization
Lund LH; Hage C; Carlstrom M; Stahlberg M; Stromberg P; Westerberg G; Lovati E; Gordon A; Sjodahl J; Andersson DC; Pironti G
Conference publication: EUROPEAN HEART JOURNAL. 2025;46
Dietary nitrate enhances cardiac function in HFrEF by improving hemodynamics, ameliorating remodeling and resolving inflammation
Shimari M; Picozzi G; Boeder A; Dantas Guimaraes D; Zhuge Z; Lundberg JO; Carlsrom M; Lund LHL; Andersson DA; Pironti G
Conference publication: NEUROGASTROENTEROLOGY AND MOTILITY. 2025;37
Post-prandial acyl ghrelin infusion in heart failure patients increases gastric emptying rate
Webb DL; Hage C; Faxen UL; Pironti G; Thorvaldsen T; Andersson DC; Stahlberg M; Lund LH; Hellstrom PM
Meeting abstract: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(8):167377
Hierarchical S-adenosylmethionine dependency in mitochondria in heart and skeletal muscle
Rumyantseva A; Rosenberg F; Moedas M; Glasgow R; Pironti G; Bruton J; Wedell A; Hinze Y; Freyer C; Wredenberg A
Meeting abstract: EUROPEAN HEART JOURNAL. 2024;45:ehae666.1164
Post-prandial acyl ghrelin infusion in heart failure patients increases gastric emptying rate
Webb D; Hage C; Ljung-Faxen U; Pironti G; Thorvaldsen T; Andersson DC; Stahlberg M; Lund LH; Hellstrom PM
Letter: EUROPEAN JOURNAL OF HEART FAILURE. 2023;25(11):2093-2095
Acyl ghrelin infusion increases circulating growth hormone in patients with heart failure and reduced ejection fraction
Hage C; Stahlberg M; Thorvaldsen T; Faxen UL; Pironti G; Webb D-L; Hellstrom PM; Andersson DC; Lund LH
Review: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2023;10:1228789
State-of-the-art methodologies used in preclinical studies to assess left ventricular diastolic and systolic function in mice, pitfalls and troubleshooting
Pironti G
Conference publication: EUROPEAN JOURNAL OF HEART FAILURE. 2021;23:31
Impaired myofibrillar contractile function in a mouse model of rheumatoid arthritis is linked to increased citrullination of a-actin
Pironti G; Gastaldello S; Rassier D; Carlstrom M; Lund LH; Westerblad H; Yamada T; Andersson D
Editorial: FRONTIERS IN PHYSIOLOGY. 2021;11:641771
Editorial: Cardiac Fibrosis, From Lineage Tracing to Therapeutic Application
de Lucia C; Wallner M; Corradi D; Pironti G
Conference publication: EUROPEAN JOURNAL OF HEART FAILURE. 2020;22:4
Citrullination of cardiac excitation-contraction coupling proteins is linked to reduced Ca2+sensitivity of myofilament in a rheumatoid arthritis mouse model.
Pironti G; Gastaldello S; Rassier D; Lund L; Andersson DC
Conference publication: ACTA PHYSIOLOGICA. 2017;219:20-21
Abnormal cardiomyocyte Ca²⁺ handling in the Collagen Antibody-Induced Arthritis (CAIA) mouse model for rheumatoid arthritis
Pironti G; Agalave A; Lanner J; Svensson C; Andersson D
Conference publication: ACTA PHYSIOLOGICA. 2017;219:16-17
The mitochondrial NDUFA4L2 protein: a novel modulator of skeletal muscle mass and force
Chaillou T; Hynynen H; Ferreira D; Pironti G; Andersson D; Ruas J; Tavi P; Lanner J
Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S186
NDUFA4L2-Connecting Metabolic Signals and Mitochondrial Function in Cardiac and Skeletal Muscle
Chaillou T; Hynynen H; Ferreira D; Pironti G; Kenne E; Andersson DC; Ruas JL; Tavi P; Lanner JT
Conference publication: EUROPEAN HEART JOURNAL. 2016;37:707
Akap1 deficiency promotes mitochondrial aberrations and exacerbates cardiac injury following permanent coronary ligation via enhanced mitophagy and apoptosis
Cattaneo F; Schiattarella G; Pironti GL; Magliulo F; Carotenuto G; Pirozzi M; Borzacchiello D; Paolillo R; Boccella N; Lombardi A; Sepe M; Feliciello A; Trimarco B; Esposito G; Perrino C
Corrigendum: PLOS ONE. 2016;11(7):e0158934
Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis (vol 11, e0154076, 2016)
Schiattarella GG; Cattaneo F; Pironti G; Magliulo F; Carotenuto G; Pirozzi M; Polishchuk R; Borzacchiello D; Paolillo R; Oliveti M; Boccella N; Avvedimento M; Sepe M; Gargiulo G; Lombardi A; Busiello RA; Trimarco B; Esposito G; Feliciello A; Perrino C
Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):598A-599A
Enhanced Cardiac Contractility and Ca²⁺ Signalling Following Dietary Nitrate Supplementation in Mice
Ivarsson N; Pironti G; Yang J; Farinotti AB; Jonsson W; Svensson C; Westerblad H; Weitzberg E; Lundberg J; Pernow J; Lanner J; Andersson DC
Conference publication: CIRCULATION RESEARCH. 2015;117
Pacemaker Induced Transient Asynchrony (PITA) Restores Contractile Reserve in Synchronous Heart Failure
Kirk JA; Chakir K; Lee K; Pironti G; Ranek MJ; Tunin RS; de Tombe P; Shenoy SK; Rockman HA; Craig R; Kass DA
Conference publication: CIRCULATION RESEARCH. 2014;115
MiR-133 Modulates the Beta1-Adrenergic Receptor Transduction Cascade
Castaldi A; Zaglia T; Di Mauro V; Carullo P; Viggiani G; Borile G; Di Stefano B; Schiattarella GG; Gualazzi MG; Elia L; Stirparo GG; Pironti G; Kunderfranco P; Colorito ML; Esposito G; Bang M-L; Mongillo M; Condorelli G; Catalucci D
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Forskningsbidrag

The contribution of mitochondrial methylation potential on cardiac function
Swedish Heart-Lung Foundation
1 januari 2022 - 31 december 2022
Kliniska och experimentella studier på hjärta, muskel och kontraktil funktion vid reumatisk sjukdom.
Swedish Heart-Lung Foundation
1 januari 2022 - 31 december 2023

Anställningar

Senior Forskningsspecialist, Medicin, Solna, Karolinska Institutet, 2022-
Senior Forskningsspecialist, Fysiologi och farmakologi, Karolinska Institutet, 2023-2026
Forskare, Medicin, Solna, Karolinska Institutet, 2019-2022
Forskarassistent, Medicin, Huddinge, Karolinska Institutet, 2018-2019

Examina och utbildning

Docent, Fysiologi och anatomi, Karolinska Institutet, 2026

Artiklar

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Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI